CN110770256A - 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 - Google Patents
靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 Download PDFInfo
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Abstract
本发明公开了一种全新的靶向AXL的单克隆抗体以及抗体‑药物偶联物。本发明还公开了制备所述抗体、抗体‑药物偶联物的方法。本发明的AXL抗体能够高效,高特异性地结合纯化的人AXL蛋白和多种肿瘤细胞表面的AXL,所述人源化抗体同样具有很高的亲和力及很低的免疫原性,所述AXL抗体‑药物偶联物对AXL高表达的肿瘤具有显著的抗肿瘤作用。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201810464287.1A CN110483639A (zh) | 2018-05-15 | 2018-05-15 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
CN2018104642871 | 2018-05-15 | ||
PCT/CN2019/086475 WO2019218944A2 (zh) | 2018-05-15 | 2019-05-10 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
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CN110770256A true CN110770256A (zh) | 2020-02-07 |
CN110770256B CN110770256B (zh) | 2022-08-19 |
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CN201810464287.1A Pending CN110483639A (zh) | 2018-05-15 | 2018-05-15 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
CN201980002582.8A Active CN110770256B (zh) | 2018-05-15 | 2019-05-10 | 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途 |
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US (1) | US11939386B2 (zh) |
EP (1) | EP3808773A4 (zh) |
JP (1) | JP2021530436A (zh) |
CN (2) | CN110483639A (zh) |
CA (1) | CA3100260A1 (zh) |
WO (1) | WO2019218944A2 (zh) |
Cited By (3)
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CN113444180A (zh) * | 2021-06-16 | 2021-09-28 | 上海鑫湾生物科技有限公司 | 靶向axl蛋白的抗体及其抗原结合片段、其制备方法和应用 |
CN114517226A (zh) * | 2021-12-24 | 2022-05-20 | 南京鼓楼医院 | Axl作为***诊断和治疗靶点的应用 |
CN116715774A (zh) * | 2023-05-12 | 2023-09-08 | 武汉爱博泰克生物科技有限公司 | 针对人axl的兔单克隆抗体及其制备方法和应用 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3856783A1 (en) * | 2018-09-26 | 2021-08-04 | Genmab A/S | Axl-specific antibodies for treatment of non-small cell lung cancer |
CN113045664B (zh) * | 2019-11-28 | 2023-05-12 | 尚健单抗(北京)生物技术有限公司 | 一种分离的结合抗原axl的蛋白及其用途 |
CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
CN115125272B (zh) * | 2021-03-29 | 2024-04-19 | 复旦大学 | 一种car-t治疗载体及其构建方法和应用 |
CN116102658A (zh) * | 2021-11-09 | 2023-05-12 | 四川大学华西医院 | 基于gas6构建的嵌合抗原受体免疫细胞制备及其应用 |
WO2024040114A2 (en) * | 2022-08-18 | 2024-02-22 | BioLegend, Inc. | Anti-axl antibodies, antigen-binding fragments thereof and methods for making and using the same |
WO2024065297A1 (zh) * | 2022-09-28 | 2024-04-04 | 复旦大学 | 嵌合抗原受体及其衍生物和应用 |
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- 2019-05-10 CA CA3100260A patent/CA3100260A1/en not_active Abandoned
- 2019-05-10 EP EP19803867.1A patent/EP3808773A4/en not_active Withdrawn
- 2019-05-10 WO PCT/CN2019/086475 patent/WO2019218944A2/zh unknown
- 2019-05-10 JP JP2020564443A patent/JP2021530436A/ja not_active Ceased
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---|---|---|---|---|
CN113444180A (zh) * | 2021-06-16 | 2021-09-28 | 上海鑫湾生物科技有限公司 | 靶向axl蛋白的抗体及其抗原结合片段、其制备方法和应用 |
CN114517226A (zh) * | 2021-12-24 | 2022-05-20 | 南京鼓楼医院 | Axl作为***诊断和治疗靶点的应用 |
CN114517226B (zh) * | 2021-12-24 | 2023-10-10 | 南京鼓楼医院 | Axl作为***诊断和治疗靶点的应用 |
CN116715774A (zh) * | 2023-05-12 | 2023-09-08 | 武汉爱博泰克生物科技有限公司 | 针对人axl的兔单克隆抗体及其制备方法和应用 |
CN116715774B (zh) * | 2023-05-12 | 2023-11-24 | 武汉爱博泰克生物科技有限公司 | 针对人axl的兔单克隆抗体及其制备方法和应用 |
Also Published As
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EP3808773A4 (en) | 2022-02-23 |
US11939386B2 (en) | 2024-03-26 |
CN110770256B (zh) | 2022-08-19 |
US20210214447A1 (en) | 2021-07-15 |
EP3808773A2 (en) | 2021-04-21 |
CN110483639A (zh) | 2019-11-22 |
CA3100260A1 (en) | 2019-11-21 |
JP2021530436A (ja) | 2021-11-11 |
WO2019218944A2 (zh) | 2019-11-21 |
WO2019218944A3 (zh) | 2020-01-02 |
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