CN110754664A - Composition for preventing osteoporosis - Google Patents

Composition for preventing osteoporosis Download PDF

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Publication number
CN110754664A
CN110754664A CN201911235880.XA CN201911235880A CN110754664A CN 110754664 A CN110754664 A CN 110754664A CN 201911235880 A CN201911235880 A CN 201911235880A CN 110754664 A CN110754664 A CN 110754664A
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parts
extract
composition
bone
osteoporosis
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CN201911235880.XA
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王晓兰
陈跃峰
明磊国
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Beijing Kainengting Stem Cell Technology Research Institute Co Ltd
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Beijing Kainengting Stem Cell Technology Research Institute Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487—Psoralea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention discloses a composition for preventing osteoporosis, and belongs to the field of health-care food. The composition for preventing osteoporosis is prepared from the following raw materials: 10-20 parts of epimedium extract, 5-15 parts of soybean isoflavone, 5-15 parts of hop extract, 2-10 parts of eucommia bark extract, 2-10 parts of fructus psoraleae extract, 2-8 parts of radix puerariae extract and 2-8 parts of raspberry extract. The raw materials are synergistic, the metabolic balance of the bone is reconstructed, the osteoporosis and the osteoarthritis are effectively prevented, the bone health is improved and regulated, and particularly the bone health problem caused by human body aging is solved.

Description

Composition for preventing osteoporosis
Technical Field
The invention belongs to the field of health-care food, and particularly relates to a composition for preventing osteoporosis.
Background
Osteoporosis is a systemic, metabolic disease of bone characterized by low bone mass and microstructural destruction of bone tissue and can lead to increased bone fragility and susceptibility to fracture. The disease is common in the elderly, but it can occur in all age periods. Osteoporosis can be divided into primary and secondary types. Primary osteoporosis refers to the absence of other diseases that cause the disease; secondary osteoporosis is a decrease in the amount of bone tissue due to various systemic or endocrine metabolic diseases. In addition, localized or generalized osteoporosis may also be classified according to the site of occurrence.
China is the country with the most osteoporosis patients worldwide, and the severity of the osteoporosis is second to that of circulatory system diseases. The data show that the total disease rate of osteoporosis is 12.4% in China, and the total number of people is more than 1.6 hundred million. Experts predict that the number of patients with osteoporosis and low bone mass in China will increase to 2.8 hundred million by 2020. Most patients have no symptoms in the early stage, then have limb weakness and bone joint pain along with gradual loss of human bone, and even fall into fracture after being knocked slightly carelessly.
The medicines clinically used for treating osteoporosis at present mainly comprise nutritional supplements (calcium preparations and vitamin D3), bisphosphates, hormones, fluorides, calcitonin, Chinese patent medicines and the like. Nutritional supplements such as vitamin D and derivatives, which have low absorption conversion rates and are prone to hypercalcemia; the bisphosphonate often causes gastrointestinal side reactions and adverse reactions such as mandibular necrosis, femoral fracture, atrial fibrillation and the like, which leads to poor medication compliance of patients; hormones increase the risk of patients suffering from breast cancer and cervical cancer; the calcitonin can cause allergy and adverse reactions of the nervous system and the digestive system after being taken for a long time; fluoride is prone to cause necrosis of alveolar bone and jaw bone. The Chinese patent medicine mainly takes the medicines for tonifying the liver and the kidney, strengthening the spleen and nourishing the stomach, and activating the blood and promoting the circulation of blood as main components, and has low effective components, so that the development of a product with high effective component content, clear action mechanism, safety and low side effect is urgent.
Disclosure of Invention
The invention aims to solve the technical problem of providing a safe and effective composition for preventing osteoporosis, which is prepared from medicinal and edible and health-care food raw materials. The product concentrates the functional substances in the raw materials, is safe and efficient, and has no side effect. Can reestablish the balance of bone metabolism, effectively prevent osteoporosis and osteoarthritis, and keep away from chronic diseases of rheumatic bone diseases and the like.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the composition for preventing osteoporosis consists of the following components: 10-20 parts of epimedium extract, 5-15 parts of soybean isoflavone, 5-15 parts of hop extract, 2-10 parts of eucommia bark extract, 2-10 parts of fructus psoraleae extract, 2-8 parts of radix puerariae extract and 2-8 parts of raspberry extract.
Further, the composition for preventing osteoporosis consists of the following components: 15 parts of epimedium extract, 10 parts of soybean isoflavone, 10 parts of hop extract, 5 parts of eucommia bark extract, 5 parts of fructus psoraleae extract, 5 parts of radix puerariae extract and 5 parts of raspberry extract.
Furthermore, the content of icariin in the epimedium extract is not less than 10%.
Further, the isoflavone content in the soybean isoflavone is not less than 40%.
Further, the content of flavone in the hop extract is not less than 10%.
Furthermore, the eucommia bark, the fructus psoraleae and the radix puerariae are all proportional extracts.
Further, the composition can be made into tablet, capsule, granule or pill.
After the flavone is modified by isopentenyl, the fat solubility and the affinity to a biological membrane are increased, and a plurality of physiological activities are influenced. Isopentenyl flavones are present in the common Chinese medicines including fructus Psoraleae, herba Epimedii, Glycyrrhrizae radix, and flos Lupuli. Compared with flavonoid compounds, the prenylflavonoids have more outstanding biological activity, mainly comprise the functions of promoting stem cell differentiation, improving osteoporosis, resisting inflammation, regulating immunity and the like.
Icariin is an effective component of epimedium herb, is a good bone induction active component, and can induce mesenchymal stem cells to differentiate to form bone cells. It can not only improve differentiation ability of osteoblast and proliferation ability, but also reduce osteoclast formation and bone resorption, and improve osteoporosis.
Bu Gu Zhi has warm nature and pungent and bitter taste, and has the actions of tonifying kidney and strengthening yang, securing essence and reducing urination, warming spleen and checking diarrhea, absorbing qi and relieving asthma. The fructus Psoraleae extract can obviously promote ALP activity of osteoblast and I type collagen secretion, enhance osteocalcin mRNA expression, and stimulate bone formation, thereby playing the role of resisting osteoporosis.
Soy isoflavones are natural estrogens and are secondary metabolites of soybeans during their growth. Animal experiments show that the Wnt signal path is inactivated due to the low estrogen level in the ovariectomized rats, and the soybean isoflavone can activate the Wnt signal path, so that the differentiation and the proliferation of osteoblasts are promoted.
The isopentenyl flavonoid compounds contained in the hops have plant estrogen-like effect, and can be combined with estrogen receptors in human bodies, thereby playing a role in resisting bone loss. The xanthohumol is a representative component in the compound, and can obviously improve the estrogen level of an ovariectomized mouse, reduce the high bone conversion rate, improve the bone trabecular microenvironment and enhance the bone density. At the osteoblast level, xanthohumol can promote osteoblast proliferation, alkaline phosphatase activity and bone mineralization level, and can also improve the expression of osteopontin, bone sialoprotein and bone morphogenetic protein.
The Chinese herbal medicines such as eucommia bark, kudzuvine root, raspberry and the like are reported in experimental research and have the effects of reducing bone resorption, promoting bone formation and increasing bone density.
The invention has the beneficial effects that:
1. the invention provides a composition for preventing osteoporosis, which is different from the traditional Chinese medicine, adopts a traditional Chinese medicine extract, has definite functional components and high content of active substances.
2. The high-purity isopentenyl flavone can effectively regulate and control signal paths related to stem cells and bone metabolism, promote differentiation and proliferation of osteoblasts, inhibit proliferation of osteoclasts, regulate balance of bone metabolism and keep bones healthy.
3. The product is prepared from raw materials of medicinal and edible food and health-care food, and has no side effect after long-term administration. Besides preventing osteoporosis, the traditional Chinese medicine composition can also supplement female estrogen and relieve female climacteric symptoms without side effects of estrogen treatment.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
In this embodiment, a composition for preventing osteoporosis comprises the following components: 15 parts of epimedium extract, 10 parts of soybean isoflavone, 10 parts of hop extract, 5 parts of eucommia bark extract, 5 parts of fructus psoraleae extract, 5 parts of radix puerariae extract and 5 parts of raspberry extract.
Example 2
In this embodiment, a composition for preventing osteoporosis comprises the following components: 10 parts of epimedium extract, 10 parts of soybean isoflavone, 8 parts of hop extract, 8 parts of eucommia bark extract, 5 parts of fructus psoraleae extract, 5 parts of kudzu root extract and 4 parts of raspberry extract.
Example 3
In this embodiment, a composition for preventing osteoporosis comprises the following components: 20 parts of epimedium extract, 8 parts of soybean isoflavone, 8 parts of hop extract, 5 parts of eucommia bark extract, 5 parts of malaytea scurfpea fruit extract, 5 parts of kudzu root extract and 5 parts of raspberry extract.
Example 4
In this embodiment, a composition for preventing osteoporosis comprises the following components: 12 parts of epimedium extract, 12 parts of soybean isoflavone, 10 parts of hop extract, 5 parts of eucommia bark extract, 6 parts of fructus psoraleae extract, 3 parts of kudzu root extract and 5 parts of raspberry extract.
Example 5
In this embodiment, a composition for preventing osteoporosis comprises the following components: 12 parts of epimedium extract, 9 parts of soybean isoflavone, 10 parts of hop extract, 5 parts of eucommia bark extract, 6 parts of fructus psoraleae extract, 4 parts of kudzu root extract and 2 parts of raspberry extract. Sieving the above materials with 2 parts of xylitol and 20 parts of resistant dextrin, mixing, adding 80% ethanol to obtain soft material, wet granulating, drying, sieving with 18 mesh sieve, grading, adding 1 part of magnesium stearate, mixing, and pressing into 0.6 g/tablet.

Claims (7)

1. A composition for preventing osteoporosis, comprising: 10-20 parts of epimedium extract, 5-15 parts of soybean isoflavone, 5-15 parts of hop extract, 2-10 parts of eucommia bark extract, 2-10 parts of fructus psoraleae extract, 2-8 parts of radix puerariae extract and 2-8 parts of raspberry extract.
2. The composition for preventing osteoporosis of claim 1, which comprises: 15 parts of epimedium extract, 10 parts of soybean isoflavone, 10 parts of hop extract, 5 parts of eucommia bark extract, 5 parts of fructus psoraleae extract, 5 parts of radix puerariae extract and 5 parts of raspberry extract.
3. A composition as in claim 1 or 2 wherein the icariin content of the epimedium extract is not less than 10%.
4. A composition according to claim 1 or 2, wherein the isoflavone content in the soy isoflavones is not less than 40%.
5. A composition according to claim 1 or 2, wherein the hop extract has a content of flavone of not less than 10%.
6. The composition according to claim 1 or 2, wherein the eucommia ulmoides, the fructus psoraleae and the radix puerariae are proportional extracts.
7. The composition according to claim 1 or 2, wherein the composition is formulated as a tablet, capsule, granule or pill.
CN201911235880.XA 2019-12-05 2019-12-05 Composition for preventing osteoporosis Pending CN110754664A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030010352A (en) * 2001-07-26 2003-02-05 칼리지파마(주) Health foods composition including Eucommia ulmoides Oliver and Isoflavone
CN103751529A (en) * 2014-02-11 2014-04-30 王雪雁 Traditional Chinese medicine composition for treating female postmenopausal osteoporosis and preparation method thereof
CN103751516A (en) * 2014-01-06 2014-04-30 薛清佩 Chinese herbal medicine formula for treating osteoporosis and preparation method thereof
CN109549969A (en) * 2017-09-26 2019-04-02 东莞自然衡健康科技有限公司 A kind of flavonoids health care product and preparation method thereof for preventing and treating osteoporosis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030010352A (en) * 2001-07-26 2003-02-05 칼리지파마(주) Health foods composition including Eucommia ulmoides Oliver and Isoflavone
CN103751516A (en) * 2014-01-06 2014-04-30 薛清佩 Chinese herbal medicine formula for treating osteoporosis and preparation method thereof
CN103751529A (en) * 2014-02-11 2014-04-30 王雪雁 Traditional Chinese medicine composition for treating female postmenopausal osteoporosis and preparation method thereof
CN109549969A (en) * 2017-09-26 2019-04-02 东莞自然衡健康科技有限公司 A kind of flavonoids health care product and preparation method thereof for preventing and treating osteoporosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
龚剑秋等: "覆盆子抗骨质疏松化学组成及抗骨质疏松活性成分研究", 《中华中医药学刊》 *

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