CN110742953A - A pharmaceutical composition for treating acne and preparation method thereof - Google Patents
A pharmaceutical composition for treating acne and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a pharmaceutical composition for treating acne and a preparation method thereof, wherein the pharmaceutical composition is prepared from the following raw material medicines in parts by weight: 25-35 parts of rhizoma cyperi, 16-24 parts of salvia miltiorrhiza and 10-14 parts of wild chrysanthemum flower, or is prepared from the following raw material medicines in parts by weight: 25-35 parts of rhizoma cyperi and 17-24 parts of semen cuscutae.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for treating acne and a preparation method thereof.
Background
The pathogenesis of acne is not completely clarified, and the traditional Chinese medicine holds that【1】The disease is caused by wind heat in lung channel, dampness and heat in stomach and intestine, dysfunction of spleen in transportation and stagnation of skin; for treatment, it is suitable to disperse wind and lung, clear heat and resolve dampness. Modern medicine believes that androgens are increased, sebum production is increased, cortical hyperkeratosis, and perifollicular inflammation caused by abnormalities in dermatophytes (mainly acne bacillus and staphylococcus albus).
Acne is commonly called pox, has various causes and 70 to 87 percent of morbidity【2】The course of the disease is from several years to ten years. At present, no medicament with good curative effect exists, scars and pits are easy to leave on the face, the case of disfiguration is not rare, and part of patients are deeply harmed by bad advertisement products. The western medicine hospitals do not have a regular therapy with good curative effect. The treatment options for acne are very different among doctors, some treatment methods have uncertain curative effect, and individual methods even have the same effectCan cause damage to patients【2】. Mainly due to the lack of effective drugs. Now called the best medical protocol【3】【4】：
(1) The vitamin A acid has partial surface effect, but has great toxic and side effects.
(2) Antibiotics, which reduce the inflammation of the skin that has already formed acne, have partial surface curative effects, and can not be used for a long time, and unexpected toxic and side effects can occur even if the antibiotics are used for a short time.
(3) The hormones have anti-inflammatory effect, are as good as acne focus, but actually cover the disease condition, have no substantial treatment effect and cannot avoid toxic or side effect.
(4) Sulfur, salicylic acid and dapsone are basically ineffective in treating acne and are all ineffectual medicines.
The existing traditional Chinese medicine therapy for treating acne has the defects of excessive varieties of traditional Chinese medicine raw materials, unclear effective components, large side effect, poor treatment effect and the like.
Acne needs to be treated for a long time, and various current treatment medicines are not suitable for long-time application, lack of good treatment medicines and are also the difficulties of current treatment. Therefore, the medicament with accurate curative effect and small toxic and side effect is urgently needed.
Reference documents:
【1】 Xudesheng and Guoxianzhen, seventh edition of integrated knowledge and skills in TCM (M), published by Chinese medical science and technology, 2018: 105-.
【2】 The expert group of Chinese acne treatment guidelines, "Chinese acne treatment guidelines (revised 2014).
【3】 Wang Daolu and Liu Xin Min, second edition of medical Manual (M) of general practitioner, published by Beijing chemical industry Press, 2014: 511-.
Zhangshige, second edition of pharmacist consulted frequently asked questions (M), published by beijing chemical industry press, 2009: 332-.
Disclosure of Invention
In order to at least partially overcome the defects in the prior art, the invention provides a pharmaceutical composition for treating acne and a preparation method thereof, and the pharmaceutical composition has the advantages of high efficiency, low toxicity, short treatment course and the like in the aspect of treating acne.
According to one aspect of the invention, the invention provides a pharmaceutical composition for treating acne, which is prepared from the following raw material medicines in parts by weight: 25-35 parts of rhizoma cyperi, 16-24 parts of salvia miltiorrhiza and 10-14 parts of wild chrysanthemum, for example, 10g is used as one part, 30 parts of rhizoma cyperi, 20 parts of salvia miltiorrhiza and 12 parts of wild chrysanthemum are used;
or the pharmaceutical composition is prepared from the following raw materials in parts by weight: 25-35 parts of rhizoma cyperi and 17-24 parts of semen cuscutae, for example, 10g of the traditional Chinese medicine composition is taken as one part, 30 parts of rhizoma cyperi can be taken as one part, 20 parts of semen cuscutae can be taken as another part, and the like.
According to an embodiment of the present invention, the pharmaceutical composition may be a pill, a tablet, a capsule, a granule, an oral liquid, a decoction, or the like.
According to another aspect of the present invention, there is also provided a method for preparing a pharmaceutical composition for treating acne, comprising the steps of:
(1) weighing raw materials, putting into a container, adding a proper amount of water, and soaking for a certain time;
(2) covering and sealing the container, heating to slightly boil, and keeping for a certain time, and stirring intermittently;
(3) cooling and filtering to obtain a filter material and primary filtrate;
(4) adding a proper amount of water into the filter material again, and repeating the steps (2) and (3) to obtain a secondary filtrate;
(5) mixing the primary filtrate and the secondary filtrate, standing, and filtering to obtain upper clear liquid to obtain medicinal liquid.
According to an embodiment of the present invention, the method further comprises further processing the liquid medicine obtained in step (5) to prepare a pharmaceutical composition in the form of pills, tablets, capsules, granules, oral liquid or decoction.
According to an embodiment of the present invention, the step (5) includes adding appropriate amounts of paraben (e.g., ethylparaben, propylparaben, etc.) and sodium saccharin prior to filtration or in the supernatant, thereby preparing the pharmaceutical composition in the form of an oral liquid.
Compared with the prior art, the pharmaceutical composition has a plurality of advantages:
(1) compared with the existing treatment method, the curative effect is higher, the healing process is shortened, and the cure hope and the confidence of the patient are improved.
(2) Is a pure Chinese medicinal preparation without adding antibiotics and hormone, has small toxic and side effects, and reduces cost.
(3) The dosage is less: the dosage of the traditional Chinese medicine therapy is more than half bowl, and compared with the traditional Chinese medicine therapy, the dosage of the prescription is less, one mouth is taken at a time, and the medicine core fear of patients is reduced.
(4) The treatment method has the advantages of less drug varieties, reduced physicochemical reaction and toxic and side effects among raw materials; for example, as an oral liquid, the traditional Chinese medicine composition can be taken orally without external application, acupuncture and moxibustion are not needed, and complicated treatment methods such as cyst injection and the like are not needed, so that an ideal curative effect can be achieved; and the risk is small, the treatment is simple and convenient, and the treatment compliance is improved.
Detailed Description
The present invention is described in further detail below with reference to preferred embodiments, which are intended to be exemplary in nature and not to limit the application or uses of the disclosure.
The experimental procedures in the following examples are conventional unless otherwise specified. The test materials used in the following examples were purchased from a conventional reagent store unless otherwise specified.
The oral liquid has the advantages of large dispersion degree, wide contact area, quick absorption, quick response, convenient sub-dosage, easy taking and the like, so the oral liquid is taken as an example hereinafter. It is understood that the present invention may be made into other dosage forms such as tablets, granules, etc., and the methods for making such dosage forms are well known in the art and thus not described in detail.
Example 1
The raw material medicaments: 26 parts of nutgrass galingale rhizome (total 260g), 18 parts of salvia miltiorrhiza (total 180g) and 10 parts of wild chrysanthemum (total 100g), wherein all the raw material medicines are dried and dehydrated.
The preparation method comprises the following steps:
soaking the 3 medicines of the salvia miltiorrhiza, the wild chrysanthemum and the nutgrass galingale rhizome in purified water which is about 4 times (for example, the medicines are immersed till the medicines are about 2-4cm higher) for about 24 hours, stirring for a plurality of times, covering and heating to slightly boil, intermittently stirring for 10 minutes for example, keeping heating for a proper time, keeping heating for 1 hour in the embodiment, optionally, other times such as 50 minutes-2 hours and the like, cooling until no steam is emitted basically, filtering by using double-layer medical gauze (it should be understood that other filters can be adopted), and singly discharging the filtrate.
Adding purified water about 1.5 times of the 3 kinds of medicines into the filtered residue, repeating the above steps, and filtering for the second time to obtain secondary filtrate.
Combining the filtrates, adding 20ml 5% ethyl hydroxybenzoate solution and saccharin sodium (known to those skilled in the art, as broad-spectrum high-efficiency food preservative, such as nipagin can be added in an amount of 0.03-0.1%, or other appropriate amount; and saccharin sodium can be added as flavoring agent for adjusting taste, and optionally adding appropriate amount), stirring, standing for about 12 hr, filtering to obtain supernatant, filtering with a filter screen with appropriate pore size, such as 10-30 μm, such as 20 μm, and packaging and labeling to obtain oral liquid.
Example 2
The raw material medicaments: 26 parts of rhizoma cyperi and 19 parts of semen cuscutae, wherein the raw material medicines are dried and dehydrated.
The preparation method comprises the following steps:
soaking the medicine in purified water about 3 times of the total amount of semen Cuscutae and rhizoma Cyperi for about 24 hr, stirring for several times, heating with water bath to slightly boil, intermittently stirring for 10 min, and maintaining the heating for a suitable time (1 hr in this example, or other times such as 50 min-2 hr, etc.), cooling to substantially no steam, squeezing and filtering with double-layer medical gauze (it should be understood that other filters may be used), and standing the filtrate alone.
And adding purified water with the amount about 2 times of the medicine amount into the filtered medicine residues, repeating the steps, and filtering for the second time to obtain secondary filtrate.
Mixing the filtrates, refrigerating and standing for about 24 hours in a refrigerator, filtering to obtain supernatant, filtering with a filter screen with proper pore size, such as 10-30 μm, such as 20 μm, adding appropriate amount of ethylparaben and saccharin sodium, stirring, packaging, and making into oral liquid.
Example 3
The raw material medicaments: 30 parts of nutgrass galingale rhizome, 21 parts of danshen root and 11 parts of wild chrysanthemum flower, and other conditions and steps are the same as those in the embodiment 1.
Example 4
The raw material medicaments: 34 parts of nutgrass galingale rhizome, 23 parts of danshen root and 14 parts of wild chrysanthemum flower, and other conditions and steps are the same as those in the example 1.
Example 5
The raw material medicaments: 31 parts of nutgrass galingale rhizome and 21 parts of south dodder seed, and the other conditions and steps are the same as those in the example 2.
Example 6
The raw material medicaments: 35 parts of nutgrass galingale rhizome and 23 parts of south dodder seed, and the other conditions and steps are the same as those in the example 2.
Clinical experiments
130 patients diagnosed with acne, 20 years old in the youngest and 48 years old in the youngest, were randomly divided into 6 treatment groups, each of which was 25, and the oral liquid of the above examples 1-6 was administered to each group at a dose of 40ml-50ml each time, 2 times a day, for 1 treatment course (45 days). The clinical effect was observed and recorded, and the specific results are shown in table 1.
Criteria for efficacy assessment
And (3) curing: the clinical symptoms disappear completely, and the normal examination is carried out;
the effect is shown: the clinical symptoms are relieved, the disease condition is controlled, and the examination is improved or normal;
and (4) invalidation: the clinical symptoms are not obviously improved or aggravated.
TABLE 1 results of clinical experiments
Typical case
1. After taking the pharmaceutical composition of the embodiment 5 of the invention for three weeks, the acne on the face completely disappears, and no relapse is observed in one year after one treatment course;
2. zhao, man, age 33. staff of the company, affected by acne for many years, had dispersed pustule acne on the face, and after taking the pharmaceutical composition of the embodiment 3 of the invention for one treatment course, the acne on the face completely disappeared without obvious scars on the face, and no recurrence was observed in the next year.
After more than 100 cases of treatment, the traditional Chinese medicine has obvious curative effect (no new acne grows out or individual acne grows out, and the original acne gradually shrinks and disappears) generally about 20 days, takes effect in 5 days as the fastest and is cured within 15 days. The Chinese medicinal composition also takes effect for more than 20 days for people with high learning and working pressure, and the patients are cured slowly, but the patients can be cured basically in one treatment course. As shown in the above table, the cure rate of the pharmaceutical composition of the present invention is above 84% in a course of treatment, and the effective rate is 100%. Provides a new high-efficiency and low-toxicity therapeutic agent for treating acne.
Compared with the prior art, the invention has the following advantages:
the treatment method is simple, efficient, safe and low in risk;
the dosage is small, the fear of taking medicine is reduced, and the oral medicine is taken by 40ml-50ml once;
compared with the common traditional Chinese medicine prescription (more raw material medicines, for example, more than 15 medicines), the traditional Chinese medicine has the advantages of less medicine varieties, convenient preparation and low cost;
antibiotics, sex hormones and external medicines are not used, so that toxic and side effects of antibiotic drug resistance generation, sex hormone carcinogenesis, skin damage caused by external medicines and the like are avoided. That is, the prescription of the invention has extremely small toxic and side effects: after more than 100 cases of treatment, the phenomenon of side effect of the patient is not found, so that the traditional Chinese medicine is an ideal medicine for treating acne and provides a new treatment way for acne.
The principles and embodiments of the present invention have been described herein using specific examples, which are presented solely to aid in the understanding of the apparatus and its core concepts; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.
Claims (6)
1. The pharmaceutical composition for treating acne is characterized by being prepared from the following raw material medicines in parts by weight: 25-35 parts of rhizoma cyperi, 16-24 parts of salvia miltiorrhiza and 10-14 parts of wild chrysanthemum flower, or is prepared from the following raw material medicines in parts by weight: 25-35 parts of rhizoma cyperi and 17-24 parts of semen cuscutae.
2. The pharmaceutical composition for treating acne according to claim 1, characterized by being prepared from the following raw material medicines in parts by weight: 30 parts of rhizoma cyperi, 20 parts of salvia miltiorrhiza and 12 parts of wild chrysanthemum, or is prepared from the following raw material medicines in parts by weight: 30 parts of rhizoma cyperi and 20 parts of semen cuscutae.
3. The pharmaceutical composition for treating acne according to claim 1 or 2, characterized in that the pharmaceutical composition is a pill, tablet, capsule, granule, oral liquid or decoction.
4. A process for the preparation of a pharmaceutical composition for the treatment of acne according to any of claims 1 to 3, characterized in that it comprises the following steps:
(1) weighing raw materials, putting into a container, adding a proper amount of water, and soaking for a certain time;
(2) covering and sealing the container, heating to slightly boil, and keeping for a certain time, and intermittently stirring during the period;
(3) cooling and filtering to obtain a filter material and primary filtrate;
(4) adding a proper amount of water into the filter material again, and repeating the steps (2) and (3) to obtain a secondary filtrate;
(5) mixing the primary filtrate and the secondary filtrate, standing, and filtering to obtain upper clear liquid to obtain medicinal liquid.
5. The method according to claim 4, further comprising further processing the liquid medicine obtained in step (5) to prepare a pharmaceutical composition in the form of pill, tablet, capsule, granule, oral liquid or decoction.
6. The method according to claim 4, wherein the step (5) comprises adding appropriate amounts of paraben and sodium saccharin prior to filtration or in the supernatant, thereby preparing the pharmaceutical composition in the form of an oral liquid.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113134068A (en) * | 2021-04-12 | 2021-07-20 | 建昌帮药业有限公司 | Acne-removing composition and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113134068A (en) * | 2021-04-12 | 2021-07-20 | 建昌帮药业有限公司 | Acne-removing composition and preparation method and application thereof |
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