CN110731833A

CN110731833A - Iron-based alloy vertebral artery degradable stent

Info

Publication number: CN110731833A
Application number: CN201911020515.7A
Authority: CN
Inventors: 王瑞罡; 朱世杰; 李天晓; 李荣福
Original assignee: Zhengzhou Meigang High-Tech Biotechnology Co Ltd
Current assignee: Zhengzhou Meigang High-Tech Biotechnology Co Ltd
Priority date: 2019-10-25
Filing date: 2019-10-25
Publication date: 2020-01-31

Abstract

The invention discloses an iron-based alloy vertebral artery degradable stent, which relates to the technical field of vascular stents, in particular to an iron-based alloy vertebral artery degradable stent, and comprises a substrate layer, wherein a framework layer is arranged inside the substrate layer, the substrate layer is in a spiral structure, a drug layer is fixedly connected to the outer surface of the substrate layer, and a collagen layer is fixedly connected to the outer surface of the drug layer.

Description

Iron-based alloy vertebral artery degradable stent

Technical Field

The invention relates to the technical field of vascular stents, in particular to an iron-based alloy vertebral artery degradable stent.

Background

The intravascular stent is characterized in that an internal stent is placed in a lesion section on the basis of the expansion forming of a lumen saccule so as to achieve the purposes of supporting a blood vessel at a stenotic occlusion section, reducing the elastic retraction and reshaping of the blood vessel and keeping the blood flow of a lumen unobstructed. Some stents also have the effect of preventing restenosis.

The vertebral artery stent is a vascular stent with a physical structure which is placed in a diseased blood vessel through a surgical operation, and the conduction of a vascular occlusion section is forcibly recovered by utilizing the supporting effect of the vascular stent. With the cure of diseases and the improvement of bodies, the originally occluded blood vessel can keep unobstructed without a blood vessel stent. At this time, the intravascular stent remained in the blood vessel is removed through a surgical operation, so that the pain of a patient is increased, and the health of the patient is influenced due to the fact that the conventional vertebral artery stent cannot be degraded in vivo.

Although the degradable micro-arc blood vessel stent disclosed in the chinese patent application publication No. CN206809369U has the advantage of being degradable, the stent has the disadvantages that the stent is easy to generate thrombus due to the stenosis of the stent entrance caused by the arc shape at the front end, and the stent is weak in pressure bearing capability and bending capability and is not suitable for being arranged at the bending part.

Disclosure of Invention

() problems to be solved

Aiming at the defects of the prior art, the invention provides the iron-based alloy vertebral artery degradable stent, which solves the problems in the background technology.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme: the iron-based alloy vertebral artery degradable stent comprises a basal layer, wherein a framework layer is arranged inside the basal layer, the basal layer is of a spiral structure, a drug layer is fixedly connected to the outer surface of the basal layer, and a collagen layer is fixedly connected to the outer surface of the drug layer.

Optionally, the base layer is made of PDO, and the spiral structure of the base layer is a single spiral structure.

Optionally, the material of the framework layer is an iron-based alloy, the iron-based alloy includes at least kinds of simple metal substances such as magnesium, zinc, calcium, and the like, and the framework layer is made of a metal material.

Optionally, the drug layer comprises an antithrombotic drug and an anti-inflammatory drug.

Optionally, the collagen layer is an outermost layer, the outer surface of the collagen layer is smooth, and the inner surface of the collagen layer is smooth.

Optionally, the whole stent is cylindrical, and two ends of the collagen layer are frustum-shaped.

Optionally, the thickness of the basal layer is 0.03mm, the thickness of the drug layer is 0.02mm, and the thickness of the collagen layer is 0.02 mm.

Optionally, the degradation rate of the collagen layer is greater than that of the basal layer, and the interpretation rate of the basal layer is greater than that of the framework layer.

Optionally, the substrate layer completely wraps the carcass layer.

(III) advantageous effects

The invention provides an iron-based alloy vertebral artery degradable stent which has the following beneficial effects:

1. this iron-based alloy vertebral artery degradable support, use the setting of iron-based alloy through the casing ply, make this support possess the effect that support ability is strong, the cooperation that is the screw thread form through the casing ply sets up, can bear arterial vascular pressure and not take place to warp at the in-process that uses, thereby played and increased the effect of bearing the effect of blood vessel effect, reached the purpose that prevents the support deformation, the skeleton setting through the screw thread form, can make the support be crooked easily, can make this support use in arterial vascular crooked department, the advantage that application range has been possessed.

2. This iron-based alloy vertebral artery degradable support, both ends through collagen are the setting of frustum type, make this iron-based alloy vertebral artery degradable support possess and prevented at the support both ends because of blockking up the effect that forms the thrombus, set up for iron-based alloy through the casing ply, can slow down the speed that is degraded at the in-process that uses, prevent that the casing ply degradation from resulting in the vertebral artery can't obtain thorough treatment and block up again at the excessive speed, have reached the purpose of protecting patient.

Drawings

FIG. 1 is a side cross-sectional structural schematic view of the present invention;

FIG. 2 is a schematic cross-sectional front view of the present invention;

FIG. 3 is a schematic three-dimensional structure of a collagen layer according to the present invention;

fig. 4 is a schematic three-dimensional structure of a substrate layer of the present invention.

In the figure: 1. a base layer; 2. a framework layer; 3. a drug layer; 4. a collagen layer.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments, not all embodiments, of the present invention .

Referring to fig. 1 to 4, the present invention provides technical solutions, in which an iron-based alloy vertebral artery degradable stent includes a base layer 1, the base layer 1 is made of PDO material, a spiral structure of the base layer 1 is a single spiral structure, a skeleton layer 2 is disposed inside the base layer 1, the base layer 1 completely wraps the skeleton layer 2, the skeleton layer 2 is made of iron-based alloy, the iron-based alloy includes at least simple metal substances such as magnesium, zinc, calcium, etc., the base layer 1 is in a spiral structure, an outer surface of the base layer 1 is fixedly connected with a drug layer 3, components of the drug layer 3 include an antithrombotic drug and an anti-inflammatory drug, an outer surface of the base layer 3 is fixedly connected with a collagen layer 4, the collagen layer 4 is an outermost layer, an outer surface of the collagen layer 4 is smooth, an inner surface of the collagen layer 4 is smooth, a degradation rate of the collagen layer 4 is greater than that of the base layer 1, a degradation rate of the base layer 1 is greater than that of the collagen layer 2, a thickness of the base layer 1 is 0.03mm, a thickness of the base layer 3 is 0.02, and a cone-shaped collagen layer is in a cylinder shape.

During the use, can transport this iron-based alloy vertebral artery degradable support to vertebral artery pathological change department through sacculus conveyer, then strut vertebral artery, make blood circulate in the support inside, after collagen layer 4 is degraded, release by the medicine layer 3 of parcel, treat vertebral artery pathological change department, then matrix layer 1 and framework layer 2 successive layer are degraded.

The iron-based alloy vertebral artery degradable stent has the advantages that the framework layer 2 is arranged in a threaded matching manner, the framework layer 2 can bear the pressure of arterial blood vessels without deformation in the using process, so that the effect of increasing the action force of bearing the blood vessels is achieved, the purpose of preventing the stent from deforming is achieved, the stent can be bent easily through the threaded framework arrangement, the stent can be used at the bending position of the arterial blood vessels, the using range is , the two ends of the collagen layer 4 are arranged in a frustum shape, the iron-based alloy vertebral artery degradable stent has the effect of preventing thrombus from being formed at the two ends of the stent due to blockage, the framework layer 2 is arranged in the iron-based alloy, the degradation rate can be reduced in the using process, the situation that the arterial blood vessels cannot be treated thoroughly and blocked due to the fact that the framework layer 2 is degraded too fast is avoided, and the purpose of protecting a patient is achieved.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims

1. Iron-based alloy vertebral artery degradable stent comprises a basal layer (1) and is characterized in that: the framework layer (2) is arranged inside the substrate layer (1), the substrate layer (1) is of a spiral structure, the drug layer (3) is fixedly connected to the outer surface of the substrate layer (1), and the collagen layer (4) is fixedly connected to the outer surface of the drug layer (3).

2. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the base layer (1) is made of PDO, and the spiral structure of the base layer (1) is a single spiral structure.

3. The iron-based alloy vertebral artery degradable stent of claim 1 is characterized in that the framework layer (2) is made of iron-based alloy, and the iron-based alloy comprises kinds of simple metals such as magnesium, zinc and calcium.

4. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the components of the drug layer (3) comprise antithrombotic drugs and anti-inflammatory drugs.

5. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the collagen layer (4) is the outermost layer, the outer surface of the collagen layer (4) is smooth, and the inner surface of the collagen layer (4) is smooth.

6. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the whole bracket is cylindrical, and two ends of the collagen layer (4) are frustum-shaped.

7. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the thickness of the basal layer (1) is 0.03mm, the thickness of the medicine layer (3) is 0.02mm, and the thickness of the collagen layer (4) is 0.02 mm.

8. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the degradation rate of the collagen layer (4) is greater than that of the basal layer (1), and the degradation rate of the basal layer (1) is greater than that of the framework layer (2).

9. The iron-based alloy vertebral artery degradable stent of claim 1, wherein: the substrate layer (1) completely wraps the framework layer (2).