CN110726842B - Glucose quality control liquid - Google Patents
Glucose quality control liquid Download PDFInfo
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- CN110726842B CN110726842B CN201810786597.5A CN201810786597A CN110726842B CN 110726842 B CN110726842 B CN 110726842B CN 201810786597 A CN201810786597 A CN 201810786597A CN 110726842 B CN110726842 B CN 110726842B
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- quality control
- solution
- addition amount
- control liquid
- glucose
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- 238000003908 quality control method Methods 0.000 title claims abstract description 38
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 31
- 239000007788 liquid Substances 0.000 title claims abstract description 31
- 239000008103 glucose Substances 0.000 title claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims abstract description 18
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000001103 potassium chloride Substances 0.000 claims abstract description 9
- 235000011164 potassium chloride Nutrition 0.000 claims abstract description 9
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 6
- KDQPSPMLNJTZAL-UHFFFAOYSA-L disodium hydrogenphosphate dihydrate Chemical compound O.O.[Na+].[Na+].OP([O-])([O-])=O KDQPSPMLNJTZAL-UHFFFAOYSA-L 0.000 claims abstract description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 241000289690 Xenarthra Species 0.000 claims abstract description 4
- 150000004683 dihydrates Chemical class 0.000 claims abstract description 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims abstract description 4
- 235000019796 monopotassium phosphate Nutrition 0.000 claims abstract description 4
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000010344 sodium nitrate Nutrition 0.000 claims abstract description 4
- 239000004317 sodium nitrate Substances 0.000 claims abstract description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 30
- 229960001031 glucose Drugs 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 21
- 239000003085 diluting agent Substances 0.000 claims description 18
- 229910019142 PO4 Inorganic materials 0.000 claims description 16
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 15
- 239000010452 phosphate Substances 0.000 claims description 15
- 238000012360 testing method Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 5
- RHCSKNNOAZULRK-APZFVMQVSA-N 2,2-dideuterio-2-(3,4,5-trimethoxyphenyl)ethanamine Chemical compound NCC([2H])([2H])C1=CC(OC)=C(OC)C(OC)=C1 RHCSKNNOAZULRK-APZFVMQVSA-N 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 238000011049 filling Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000001556 precipitation Methods 0.000 claims description 2
- 238000005070 sampling Methods 0.000 claims description 2
- 238000012795 verification Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 12
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 8
- 238000012123 point-of-care testing Methods 0.000 abstract description 3
- 239000008213 purified water Substances 0.000 abstract description 2
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 abstract 1
- 235000021317 phosphate Nutrition 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 206010013457 Dissociation Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- 229940089206 anhydrous dextrose Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000012482 calibration solution Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 208000018459 dissociative disease Diseases 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- WQZGKKKJIJFFOK-UHFFFAOYSA-N hexopyranose Chemical compound OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
Abstract
The glucose quality control liquid provided by the invention comprises the following components: potassium dihydrogen phosphate, disodium hydrogen phosphate dihydrate, potassium chloride, sodium nitrate, disodium edentate dihydrate, triton x-100, parmetol k40, and distilled or purified water as solvents. The glucose quality control liquid provided by the invention can be used for quality control of POCT blood glucose meters of various brands, can meet the requirements of clinical indoor and indoor quality control application, and simultaneously saves the use cost of the total reagent.
Description
Technical Field
The invention relates to the field of medical instrument in-vitro diagnostic reagents.
Background
The main components of the glucose quality control liquid are phosphate diluent and beta-D (+) anhydrous glucose. Among them, phosphates are one of the most widely used buffers in biochemical studies, and since they are secondary dissociations, have two pKa values, buffers formulated with them have the widest pH range. beta-D (+) anhydrous dextrose is a purified, crystallized D-glucose anhydrous or contains a molecule of water of crystallization. White odorless crystalline particles or crystalline powder. Is easily soluble in water, very easily soluble in boiling water and slightly soluble in ethanol. The storage condition is 2-8 ℃. D-glucose changes its optical rotation with time when dissolved in water, gradually approaching +57.2°. This is because the solution at this time forms a stable system containing 1/3 of alpha-D-glucose and 2/3 of beta-D-glucose.
The glucose quality control liquid of the commercial glucometer generally adopts a solvent as water for injection, the pH value of the water for injection is 5.0-7.0, the conductivity is 1.3us/cm, the quality control liquid produced by the method has more adverse reactions clinically and poor stability due to the larger conductivity, the technical index pH value of water quality used by the quality control liquid prepared by us is 6.0-7.0, the water quality is more neutral, the conductivity is 0.65us/cm, and the quality of the quality control liquid is prevented from being influenced by microorganisms. Meanwhile, after the commercial quality control product is opened, the commercial quality control product can be stored at a certain temperature for 8 hours or 7 days, wherein the Langdao quality control product can be stored for a long time when being frozen at the temperature of minus 20 ℃, but the use of the commercial quality control product is more complicated for users. The diluent used in the quality control liquid prepared by the method contains Parmetol K40, so that the long-term stability of the quality control liquid is ensured, the quality control liquid is stored in a sealed manner at 2-8 ℃ for 9 months, the quality control liquid can be stored for one month after being used for bottle opening at 2-8 ℃, the quality control liquid is longer than the bottle opening valid period of the common quality control liquid, and the blood test result on an instrument is quite optimistic.
The technical indexes of the glucose quality control liquid used as an in-vitro diagnostic reagent mainly relate to accuracy and precision, and according to the related technology, the quality control liquid with the accuracy within the range of +/-11 wt% and the precision CV less than or equal to 8.00wt% is found to be suitable for POCT blood glucose analyzers of various styles on the market, and the test effect is superior to that of the reagents matched with some blood glucose meters.
Disclosure of Invention
The glucose quality control liquid provided by the invention comprises the following components: the addition amount of potassium dihydrogen phosphate is 0.055wt%, the addition amount of disodium hydrogen phosphate dihydrate is 0.237-0.238 wt%, the addition amount of potassium chloride is 0.15wt%, the addition amount of sodium nitrate is 0.019-0.020 wt%, the addition amount of disodium edentate dihydrate is 0.038-0.040 wt%, the addition amount of TritonX-100 is 0.005-0.0055 wt%, and the addition amount of Parmetol K40 is 0.05-0.06 wt%, and distilled water is used as a solvent.
The phosphate diluent not only dilutes glucose to prepare the quality control liquid, but also dilutes blood through a large number of experiments, and the quality control liquid has optimal efficacy and blood dilutability under the concentration ratio.
The glucose quality control liquid provided by the invention can be used for quality control of POCT blood glucose meters of various brands, can meet the requirements of clinical indoor and indoor quality control application, and simultaneously saves the use cost of the total reagent.
Detailed Description
The technical scheme of the invention is further described by the following specific embodiments. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting thereof.
Preparation example
The stage object of the invention is as follows:
the first stage designs a phosphate diluent technical formula containing Parmetol K40 bactericide;
preparing a glucose quality control liquid level 1 (13.6 mmol/L glucose quality control liquid level 2) of 5.80mmol/L in the second stage;
the third stage establishes a mature process flow according to the formula;
and in the fourth stage, the accuracy test, the precision test, the repeated test and the clinical calibration consistency test are carried out by utilizing the blood glucose meter and other instruments, and the blood glucose meter is formally put into production.
The final purpose is as follows: a method for preparing a glucose control solution level 1 (13.6 mmol/L glucose control solution level 2) of 5.80mmol/L for blood glucose sample detection.
1. Additional conditions required for the solutions studied in the present invention are as follows:
1.1 analytical balance (0.0001 g)
1.2 magnetic stirrer;
1.3 digital temperature controller;
1.4pH meter;
1.5 conductivity meter;
1.6 beaker;
1.7 the pH and conductivity of the formulated phosphate diluent were measured as follows:
1.7.1 taking small amounts of phosphate diluent in a small 100ml beaker;
1.7.2 inserting the electrodes of the calibrated pH meter and conductivity meter into the solution sequentially;
1.7.3 pressing the "read" buttons of the pH meter and conductivity meter, respectively;
1.7.4 wait for 1min-2min, record the reading on the pH meter and the reading on the conductivity;
2. key technical key points are as follows:
2.1 the volume of solvent for dissolving the raw materials should be 60wt% of the target volume, so that the generation of foam can be avoided;
2.2 for the organic matters Parmetol K40 and TritonX-100, one is to play a role in sterilization and disinfection, and the other is to disperse cells in discrete blood samples, so that the device is convenient to detect, and simultaneously, the surface tension of the diluent is reduced so as to reduce the generation of bubbles, eliminate the interference of the bubbles on measurement, and the substance also has the function of sheath fluid; the adding sequence is adding TritonX-100 and then adding Parmetol K40;
2.3 preparing the quality control liquid, namely preparing a concentrated solution with a certain concentration, and then diluting to ensure the uniformity of the solution;
2.4, standing the prepared glucose quality control liquid;
2.5 the invention adopts a low-rotation-speed stirring dissolution method, and stirring is required to be carried out for 30min after preparation.
2.6Parmetol K40 content should be 0.05wt% -0.06 wt%, the stability of the prepared calibration solution is better, and the test result is more accurate;
2.7 the water quality is preferably three-stage distilled water or purified water and meets certain standards.
3. Glucose control level 1 (glucose control level 2) specific preparation method:
3.1 preparing a volume of phosphate diluent, wherein the phosphate diluent comprises: the addition amount of potassium dihydrogen phosphate is 0.055wt%, the addition amount of disodium hydrogen phosphate dihydrate is 0.237-0.238 wt%, the addition amount of potassium chloride is 0.15wt%, the addition amount of sodium nitrate is 0.019-0.020 wt%, the addition amount of disodium edentate dihydrate is 0.038-0.040 wt%, the addition amount of Triton X-100 is 0.005-0.0055 wt%, the addition amount of Parmetol K40 is 0.05-0.06 wt%, and distilled water meeting a certain standard is used as a solvent;
3.2 placing 3000ml of phosphate diluent in a 5000ml beaker, placing the beaker on a magnetic stirrer, and enabling a stirring rotor to rotate at a constant speed;
3.3 then slowly adding 52.3g of beta-D (+) anhydrous glucose into a 5000ml beaker, and placing the mixture on a magnetic stirrer to continuously stir for 30min;
3.4, after the chemicals such as the water and the like are completely dissolved, adding a phosphate diluent into a 5L beaker to fix the volume to 5L;
3.5 transferring 500ml of the mixed solution into another 5L beaker, then fixing the volume to 5L by using a phosphate diluent, placing the mixed solution on a magnetic stirrer, continuously stirring for 30min, and standing for 30min;
3.6, after being uniformly dissolved, obtaining a solution before filling, putting a cellulose acetate filter membrane of 0.22um soaked in triple distilled water into a filter, and filtering for three times, thus obtaining the required glucose quality control liquid level 1 of 5.80 mmol/L;
3.7, if the solution is clear and transparent, sampling and detecting, continuously making three batches, starting to test the accuracy, and if the solution has precipitation and turbidity phenomena, removing and re-preparing;
3.8, after the test is qualified, performing an on-machine verification test by using the glucose quality control liquid level 1 with the concentration of 5.80mmol/L
Citation: YYT 0456.1-2014 reagent for blood analyzer part 1: cleaning liquid; YYT 0456.3-2014 reagent for blood analyzer part 3: a diluent; ISO18113-2 part 2: in vitro diagnostic reagent for professional use; GBT 26124-2011 clinical chemistry in vitro diagnostic kit standard (GB) YYT 0701-2008 calibrator for blood cell analyzer GBT1.1-2009 standard working guide section 1: standard construction and writing (abstract)
Effect examples
Description of the content of each substance component
Inorganic salts outside the standard range of conductivity were added to comparative example 1, and the conductivity was 40.23ms/cm, outside the standard range of conductivity of 5.00 to 6.00 ms/cm.
In comparative example 2, an excessive amount of Triton X-100 was added, and the resulting foam was extremely difficult to eliminate and required to stand for more than 30 minutes.
The addition of excess Parmetol K40 in comparative example 3 resulted in poor solution stability and failure to achieve the expected shelf life.
The materials were added in the proportions described in example 1, with a conductivity of 5.3ms/cm, and the foam produced was very easy to eliminate within the specified conductivity standards. Example 2 also has excellent electrical conductivity.
Effect example 2
In comparative example 1, disodium hydrogen phosphate dihydrate was replaced with sodium hydroxide, wherein sodium hydroxide was widely used for pH adjustment of a solution, but the sodium hydroxide was exothermic when dissolved in the solution, and the ionization balance in the solution was easily broken, so that the pH did not reach the expected range.
In comparative example 2, potassium chloride was replaced with sodium chloride, wherein the physical properties and chemical properties of potassium chloride are similar to those of sodium chloride, but the solubility of potassium chloride is higher than that of sodium chloride, so that the potassium chloride is more suitable for industrial production, and the conductivity of the potassium chloride is lower than 5.00ms/cm.
The present invention is capable of other and further embodiments and its several details are capable of modification and variation in light of the present invention, as will be apparent to those skilled in the art, without departing from the spirit and scope of the invention as defined in the appended claims.
The foregoing is only illustrative of the present invention and is not to be construed as limiting thereof, but rather as various modifications, equivalent arrangements, improvements, etc., within the spirit and principles of the present invention.
Claims (1)
1. The preparation method of the glucose quality control liquid is characterized by comprising the following steps:
1) Preparing a volume of phosphate diluent, wherein the phosphate diluent comprises: the addition amount of potassium dihydrogen phosphate is 0.055wt%, the addition amount of disodium hydrogen phosphate dihydrate is 0.237wt% to 0.238wt%, the addition amount of potassium chloride is 0.15wt%, the addition amount of sodium nitrate is 0.019wt% to 0.020wt%, the addition amount of disodium edentate dihydrate is 0.038wt% to 0.040wt%, the addition amount of TritonX-100 is 0.005wt% to 0.0055wt%, the addition amount of Parmetol K40 is 0.05wt% to 0.06wt%, and distilled water is used as a solvent;
2) Placing 3000ml of phosphate diluent in a 5000ml beaker, placing the beaker on a magnetic stirrer, and enabling a stirring rotor to rotate at a constant speed;
3) Then, 52.3g of beta-D (+) anhydrous glucose is slowly added into a 5000ml beaker, and the mixture is placed on a magnetic stirrer to be continuously stirred for 30min;
4) After the chemicals are completely dissolved, adding a phosphate diluent into a 5L beaker to fix the volume to 5L;
5) Transferring 500ml of the mixed solution into another 5L beaker, then fixing the volume to 5L by using a phosphate diluent, putting the mixed solution on a magnetic stirrer, continuously stirring for 30min, and standing for 30min;
6) After being dissolved uniformly, the solution before filling is obtained, a cellulose acetate filter membrane of 0.22um soaked in triple distilled water is put into a filter, and the solution is filtered for three times, namely the required glucose quality control liquid level 1 of 5.80 mmol/L;
7) If the solution is clear and transparent, sampling and detecting, continuously making three batches, starting to test the accuracy of the solution, and if the solution has precipitation and turbidity phenomena, removing the solution and preparing the solution again;
8) And after the test is qualified, performing an on-machine verification test by using the glucose quality control liquid level 1 with the concentration of 5.80 mmol/L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810786597.5A CN110726842B (en) | 2018-07-17 | 2018-07-17 | Glucose quality control liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810786597.5A CN110726842B (en) | 2018-07-17 | 2018-07-17 | Glucose quality control liquid |
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| CN110726842A CN110726842A (en) | 2020-01-24 |
| CN110726842B true CN110726842B (en) | 2024-01-30 |
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| CN201810786597.5A Active CN110726842B (en) | 2018-07-17 | 2018-07-17 | Glucose quality control liquid |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163297B (en) * | 1981-12-23 | 1988-09-03 | John Richard Baker | |
| JP2000262299A (en) * | 1999-03-17 | 2000-09-26 | Kainosu:Kk | Determination of glucose with glucose dehydrogenase and reagent for determining glucose |
| CN1329250A (en) * | 2001-08-03 | 2002-01-02 | 长春市迪瑞检验制品有限责任公司 | Quality control liquor for analysis of urine and its preparation method |
| CN204631039U (en) * | 2015-04-27 | 2015-09-09 | 江西恒盛晶微技术有限公司 | A kind of glucose monitoring biochip |
| CN106771112A (en) * | 2016-12-27 | 2017-05-31 | 长春迪瑞医疗科技股份有限公司 | A kind of multinomial compound quality control liquor for analysis of urine |
| CN108196058A (en) * | 2018-01-02 | 2018-06-22 | 深圳市双平泰医疗科技有限公司 | Blood glucose meter Quality Control detection method and system |
| CN109307769A (en) * | 2017-07-28 | 2019-02-05 | 上海瀚联医疗技术股份有限公司 | A kind of blood glucose solution allocation method for 12mmol/L |
-
2018
- 2018-07-17 CN CN201810786597.5A patent/CN110726842B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN163297B (en) * | 1981-12-23 | 1988-09-03 | John Richard Baker | |
| JP2000262299A (en) * | 1999-03-17 | 2000-09-26 | Kainosu:Kk | Determination of glucose with glucose dehydrogenase and reagent for determining glucose |
| CN1329250A (en) * | 2001-08-03 | 2002-01-02 | 长春市迪瑞检验制品有限责任公司 | Quality control liquor for analysis of urine and its preparation method |
| CN204631039U (en) * | 2015-04-27 | 2015-09-09 | 江西恒盛晶微技术有限公司 | A kind of glucose monitoring biochip |
| CN106771112A (en) * | 2016-12-27 | 2017-05-31 | 长春迪瑞医疗科技股份有限公司 | A kind of multinomial compound quality control liquor for analysis of urine |
| CN109307769A (en) * | 2017-07-28 | 2019-02-05 | 上海瀚联医疗技术股份有限公司 | A kind of blood glucose solution allocation method for 12mmol/L |
| CN108196058A (en) * | 2018-01-02 | 2018-06-22 | 深圳市双平泰医疗科技有限公司 | Blood glucose meter Quality Control detection method and system |
Non-Patent Citations (3)
| Title |
|---|
| 3种便携式血糖检测仪的分析性能评价;纪昕;王鑫;岳晓乐;赵丹丹;张艳华;;检验医学与临床(第07期);全文 * |
| Evaluation of a glucose meter against analytical quality specifications for hospital use.;Singh Dhatt G;Agarwal M;Bishawi B;Clinica Chimica Acta;第343卷(第1/2期);全文 * |
| 五种即时检验血糖仪的主要分析性能评价;郑松柏;张秀明;林莲英;孙蕾;马艳;罗燕玲;;检验医学(第05期);全文 * |
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