CN110693725A - Calcium alginate gel tooth root canal filling material and preparation method thereof - Google Patents
Calcium alginate gel tooth root canal filling material and preparation method thereof Download PDFInfo
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- CN110693725A CN110693725A CN201911052674.5A CN201911052674A CN110693725A CN 110693725 A CN110693725 A CN 110693725A CN 201911052674 A CN201911052674 A CN 201911052674A CN 110693725 A CN110693725 A CN 110693725A
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Abstract
A calcium alginate gel tooth root canal filling material and a preparation method thereof, belonging to the field of medical materials. The calcium alginate gel dental root canal filling material comprises 99-50% of calcium alginate gel and 1-50% of carried medicine by mass percent; the calcium alginate gel is a main body bracket material, and the carried medicine is an adjusting material for adjusting the degradation rate of the material and increasing the treatment effect. Dissolving sodium alginate in water to form a solution, dissolving calcium chloride in water to form a solution, adding the sodium alginate solution into the calcium chloride solution to form calcium alginate gel, and directly mixing the solid powder medicine with the calcium alginate gel to obtain the dental root canal filling material of the calcium alginate gel. The prepared calcium alginate gel emulsion dental canal filling material is degradable gel, has high biological safety, is convenient for clinical use in an injection type, has good fluidity, can tightly fill the dental canal, and is beneficial to inflammation control; convenient use, degradability and high safety, and can improve the curative effect of the operation.
Description
Technical Field
The invention belongs to the field of medical materials, and particularly relates to an injectable absorbable drug-loaded calcium alginate gel dental root canal filling material and a preparation method thereof.
Background
Since the first application of PGA (polyglycolic acid) to clinical orthopedics in Rokkane in 1984, experiments and clinical researches on biodegradable absorbable materials have been rapidly developed, and certain results have been achieved. Such materials are currently rapidly developing in trauma orthopedics.
Deciduous teeth, which are a special body component, are gradually absorbed by the tooth root with age and eventually fall off, so that the root canal filling material of the deciduous teeth must be absorbable. The root canal of deciduous teeth is small, the clinical operation is difficult, and the foldable material has obvious advantages. The deciduous tooth root tip is absorbed, and the material in the root canal is in direct contact with the bone tissue, so the material must be a biosafety material. The root canal therapy for deciduous teeth is difficult to fill tightly, and therefore, it is preferable that the filled drug continuously release the bacteriostatic component. The deciduous tooth root canal therapy is difficult to fill tightly, the fluidity of the gel is good, and obvious advantages are displayed. By combining the characteristics, the calcium alginate drug-loaded gel is a suitable choice.
Disclosure of Invention
The invention aims to provide a novel medical deciduous tooth root canal filling material capable of carrying a medicament, which is beneficial to formation of bone tissues, inhibits bacteria, tightly fills cavities in root canals and improves curative effect, and a preparation method thereof.
The ingredients of the calcium alginate gel dental root canal filling material are 99-50% of calcium alginate gel and 1-50% of the carried medicine according to the mass percentage; the calcium alginate gel is a main body bracket material, and the carried medicine is an adjusting material for adjusting the degradation rate of the material and increasing the treatment effect.
The structure formed by the calcium alginate gel and the carried medicine is that the medicine is evenly wrapped in the calcium alginate gel; the carried medicine can be powdered medicine, water-soluble medicine, fat-soluble medicine, acid-base liquid dissolved medicine and the like; the carried medicine can be selected from ZnO, growth factor or other antibacterial and anti-inflammatory medicines, and the growth factor can be one of fibroblast growth factor, connective tissue growth factor, platelet-derived growth factor-beta, and the like; the other antibacterial and anti-inflammatory medicines can be nano-scale granular medicines, the nano-scale granular medicines can be selected from one of nano-silver, soluble medicines, Chinese herbal medicines, Chinese patent medicines and the like, and the Chinese patent medicines can be selected from one of tetracycline, amoxicillin, metronidazole, emodin, puerarin, hedysari polysaccharide, lactoferritin and the like; the soluble medicine can be selected from vitamin C, lidocaine hydrochloride and other medicines with effects of promoting tissue healing, inhibiting bacteria and relieving pain; the Chinese herbal medicine can be selected from herba Epimedii, radix Zanthoxyli, etc. with effects of promoting blood circulation, inhibiting bacteria and promoting tissue growth.
The calcium alginate gel can be prepared by adopting an ion exchange method, the calcium alginate gel can be obtained by mixing a sodium alginate solution and calcium solutions such as calcium chloride or calcium acetate, the mass fraction of the sodium alginate aqueous solution can be 2-40%, the mass fraction of the calcium chloride can be 20-60%, and the mass fraction of the calcium acetate can be 20-60%; the calcium alginate gel may be an injectable gel.
The mixing method of the loaded medicine and the calcium alginate gel can be respectively prepared into an independent system to be independently prepared and then mixed, or the medicine and calcium chloride or sodium alginate solution are directly mixed into the gel.
The preparation method of the calcium alginate gel tooth root canal filling material comprises the following steps:
mixing with the powder-form drug: dissolving sodium alginate in water to form a solution, dissolving calcium chloride in water to form a solution, adding the sodium alginate solution into the calcium chloride solution to form calcium alginate gel, and directly mixing the solid powder medicine with the calcium alginate gel to obtain the dental root canal filling material of the calcium alginate gel.
Mixing with water-soluble drugs: dissolving water-soluble medicine in sodium alginate solution or calcium chloride solution to form medicine mixed solution, and adding the sodium alginate solution into the calcium chloride solution to form calcium alginate gel/medicine gel, thus obtaining the dental root canal filling material of calcium alginate gel.
Mixing with fat-soluble medicine: dissolving fat-soluble medicine in oily liquid such as alcohol or olive oil, mixing the medicine lipid solution with calcium chloride to form a mixed solution, placing the mixed solution in a magnetic stirrer, stirring at 1000r/min, adding the sodium alginate solution into the mixed solution, standing for alcohol volatilization to form calcium alginate gel/medicine gel, and obtaining the tooth root canal filling material of the calcium alginate gel.
The invention is provided on the basis of fully considering the characteristics of pathogenic mechanism, treatment, prognosis and the like of deciduous tooth root canal filling. The structure and the components of the material are beneficial to the recovery and the functional recovery of the pulpal apicitis and the reduction of the recurrence rate.
The prepared calcium alginate gel tooth root canal filling material is degradable gel, has high biological safety, is convenient for clinical use in an injection type, has good fluidity, can be tightly filled into a root canal, and is beneficial to inflammation control by sustained-release medicines; the prepared calcium alginate gel tooth root canal filling material is a novel medical biodegradable material capable of carrying medicine, is convenient to use, is degradable, has high safety, and can improve the curative effect of an operation.
Detailed Description
The following examples further illustrate the invention.
Example 1:
the sodium alginate is dissolved in the water to form a solution with the mass fraction of 4%, and the calcium chloride is dissolved in the water to form a solution with the mass fraction of 20%. The sodium alginate solution is dripped into the calcium chloride solution to form calcium alginate gel, and the solid powdered medicine such as nano silver nano particles is directly mixed with the formed gel to form the tooth root canal filling material of the calcium alginate gel.
Example 2:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, and mixing lactoferrin with the mass fraction of 10% with the solution to form the sodium alginate/lactoferrin solution. The calcium chloride is dissolved in water to form a solution, and the mass fraction of the solution is 20%. And dropwise adding the sodium alginate/lactoferrin solution into the calcium chloride solution to form calcium alginate/lactoferrin gel, thus obtaining the calcium alginate gel dental root canal filling material.
Example 3:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing ofloxacin and glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; dripping sodium alginate solution and ofloxacin/glacial acetic acid solution into calcium chloride solution in magnetic stirrer to form precipitate, standing for volatilizing glacial acetic acid to form calcium alginate/ofloxacin gel, and making into calcium alginate gel dental root canal filling material
Example 4:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing herba Epimedii with glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; dripping sodium alginate solution and ofloxacin/glacial acetic acid solution into calcium chloride solution in magnetic stirrer to form precipitate, standing for volatilizing glacial acetic acid to form calcium alginate/ofloxacin gel, and making into calcium alginate gel dental root canal filling material
Example 5:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing lactoferrin and glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; dripping sodium alginate solution and ofloxacin/glacial acetic acid solution into calcium chloride solution in magnetic stirrer to form precipitate, standing for volatilizing glacial acetic acid to form calcium alginate/ofloxacin gel, and making into calcium alginate gel dental root canal filling material
Example 6:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing clove oil and glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; dripping sodium alginate solution and ofloxacin/glacial acetic acid solution into calcium chloride solution in magnetic stirrer to form precipitate, standing for volatilizing glacial acetic acid to form calcium alginate/ofloxacin gel, and making into calcium alginate gel dental root canal filling material
Example 7:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing calcium hydroxide and glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; dripping sodium alginate solution and ofloxacin/glacial acetic acid solution into calcium chloride solution in magnetic stirrer to form precipitate, standing for volatilizing glacial acetic acid to form calcium alginate/ofloxacin gel, and making into calcium alginate gel dental root canal filling material
Example 8:
dissolving sodium alginate in water to form a solution with the mass fraction of 4%, mixing metronidazole and glacial acetic acid to form a solution with the mass fraction of 10%, and dissolving calcium chloride in water to form a solution with the mass fraction of 20%; and dripping the sodium alginate solution and the ofloxacin/glacial acetic acid solution into the calcium chloride solution placed in a magnetic stirrer simultaneously to form a precipitate, standing and volatilizing the glacial acetic acid to form the calcium alginate/ofloxacin gel, thus obtaining the calcium alginate gel latex dental root canal filling material.
Claims (10)
1. A tooth root canal filling material of calcium alginate gel emulsion is characterized in that the components of the material are 99 to 50 percent of calcium alginate gel and 1 to 50 percent of carried medicine according to the mass percentage; the calcium alginate gel is a main body bracket material, and the carried medicine is an adjusting material for adjusting the degradation rate of the material and increasing the treatment effect.
2. The material as claimed in claim 1, wherein the structure formed by said calcium alginate gel and the drug loaded therein is such that the drug is uniformly encapsulated in the calcium alginate gel.
3. The material as claimed in claim 1, wherein the drug is selected from the group consisting of powdered drugs, water-soluble drugs, fat-soluble drugs, and acid-base liquid-soluble drugs.
4. The material as claimed in claim 1, wherein said loaded drug is selected from ZnO, growth factor or other antibacterial and anti-inflammatory drugs, said growth factor is selected from one of fibroblast growth factor, connective tissue growth factor, platelet-derived growth factor-beta; the other antibacterial and anti-inflammatory medicines are nano-scale granular medicines, the nano-scale granular medicines are selected from one of nano-silver, soluble medicines, Chinese herbal medicines and Chinese patent medicines, and the Chinese patent medicines are selected from one of tetracycline, amoxicillin, nitrofiling, emodin, puerarin, hedysarum polybotrys polysaccharide and lactoferritin; the soluble medicine is selected from vitamin C and lidocaine hydrochloride, and has antibacterial and analgesic effects for promoting tissue healing; the Chinese herbal medicine is selected from herba Epimedii and radix Zanthoxyli with effects of promoting blood circulation, inhibiting bacteria and promoting tissue growth.
5. The material as claimed in claim 1, wherein the calcium alginate gel is prepared by ion exchange method, and the calcium alginate gel is prepared by mixing sodium alginate solution with calcium chloride or calcium acetate solution; the mass fraction of the sodium alginate aqueous solution is 2-40%, the mass fraction of the calcium chloride is 20-60%, and the mass fraction of the calcium acetate is 20-60%.
6. The calcium alginate gel dental root canal filling material of claim 1, wherein the calcium alginate gel is an injectable gel.
7. The material as claimed in claim 1, wherein the method for mixing the loaded drug and the calcium alginate gel comprises preparing the drug and the calcium alginate gel separately into separate systems and mixing the separate systems, or mixing the drug and the calcium chloride or sodium alginate solution directly into gel.
8. The method for preparing the root canal filling material of calcium alginate gel emulsion as claimed in claim 1, which comprises the following steps:
mixing with the powder-form drug: dissolving sodium alginate in water to form a solution, dissolving calcium chloride in water to form a solution, adding the sodium alginate solution into the calcium chloride solution to form calcium alginate gel, and directly mixing the solid powdery medicine with the calcium alginate gel to obtain the calcium alginate gel dental root canal filling material.
9. The second preparation method of the calcium alginate gel root canal filling material of claim 1, which is characterized by comprising the following steps:
mixing with water-soluble drugs: dissolving water-soluble medicine in sodium alginate solution or calcium chloride solution to form medicine mixed solution, and adding the sodium alginate solution into the calcium chloride solution to form calcium alginate gel/medicine gel, thus obtaining the dental root canal filling material of calcium alginate gel.
10. The third preparation method of the calcium alginate gel root canal filling material of claim 1, which is characterized by comprising the following steps: mixing with liposoluble medicine, dissolving liposoluble medicine in oily liquid such as alcohol or olive oil, mixing the medicine lipid solution with calcium chloride to form mixed solution, placing in a magnetic stirrer, stirring at 1000r/min, adding sodium alginate solution into the mixed solution, standing for alcohol volatilization to form calcium alginate gel/medicine gel, and making into dental root canal filling material.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631680A (en) * | 2012-04-19 | 2012-08-15 | 浙江大学 | Method of regulating microsphere drug-load rate by treating calcium alginate microspheres with sodium chloride solution |
| US20150147718A1 (en) * | 2013-06-26 | 2015-05-28 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
| CN110387051A (en) * | 2019-08-26 | 2019-10-29 | 宁波迪创医疗科技有限公司 | A kind of preparation method of injectable type medical grade calcium alginate powder |
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2019
- 2019-10-31 CN CN201911052674.5A patent/CN110693725A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631680A (en) * | 2012-04-19 | 2012-08-15 | 浙江大学 | Method of regulating microsphere drug-load rate by treating calcium alginate microspheres with sodium chloride solution |
| US20150147718A1 (en) * | 2013-06-26 | 2015-05-28 | Sonendo, Inc. | Apparatus and methods for filling teeth and root canals |
| CN110387051A (en) * | 2019-08-26 | 2019-10-29 | 宁波迪创医疗科技有限公司 | A kind of preparation method of injectable type medical grade calcium alginate powder |
Non-Patent Citations (1)
| Title |
|---|
| 陈路沅: "用于口腔骨组织修复藻酸钙凝胶的制备及生物学性能研究", 《用于口腔骨组织修复藻酸钙凝胶的制备及生物学性能研究》 * |
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