CN110692984A - 一种清除口腔异味的玫瑰花咀嚼片及其制备方法 - Google Patents
一种清除口腔异味的玫瑰花咀嚼片及其制备方法 Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种清除口腔异味的玫瑰花咀嚼片及其制备方法,属于清除口腔异味食品领域。该咀嚼片包含有效成分和辅料/助剂,其中,有效成分包含玫瑰花水提物4.2‑5.7份、茯苓水提物2‑2.6份、金银花水提物2‑2.6份、白菊花水提物0.3‑0.5份、蒲公英水提物1.2‑1.5份、山楂水提物2.5‑3.2份、绿茶水提物0.5‑0.6份、香菇多糖0.5‑1.2份、甘草水提物1.5‑2份、粳米3.3‑4.1份;辅料/助剂是大豆分离蛋白粉、麦芽糊精、脱味羊奶中的一种或多种的混合。本发明咀嚼片具有起效快、药味淡、效果好、安全无副作用及不产生耐药性的优点。
Description
技术领域
本发明属于日常功能性食品领域,尤其涉及清除口腔异味食品领域,具体涉及一种清除口腔异味的玫瑰花咀嚼片及其制备方法。
背景技术
口腔异味是各种原因引起的临床常见症状,其病因主要包括:1)多种口腔疾病,如龋齿、牙龈炎、牙周炎及口腔粘膜炎等引起口腔内细菌滋生,特别是厌氧菌发酵产生硫化物、吲哚和氨类,因而产生口腔异味;2)口腔邻近组织疾病,如化脓性扁桃体炎、慢性上颌窦炎、萎缩性鼻炎等产生脓性分泌物而发出臭味,同时消化性溃疡、急慢性胃炎、功能性消化不良等可伴有口臭;3)各种原因引起的唾液分泌减少,从而降低了唾液的冲刷和缓冲作用,使细菌大量滋生并分解唾液、龈沟液及食物残渣中的有机成分,产生大量的挥发性硫化物、吲哚等物质,引起口腔异味;4)食用葱、蒜、韭菜等刺激性食物以及吸烟、饮酒等导致细菌大量分解食物残渣,从而引起口腔异味;5)生活节奏紧张,工作强度大,过于劳累等原因,更能加重口臭的程度和提高频率。口腔异味患者往往不敢与人近距离交流,影响正常的人际交往,令人十分苦恼,严重影响人们的生活。
目前,针对口腔异味尚无有效的防治手段,大部分人通过咀嚼口香糖或使用漱口水来掩盖口腔异味。但口香糖大多含有增塑剂,影响身体健康;漱口水则含有酒精,对口腔黏膜刺激性大,且长期使用可能会改变口腔微生态环境。另外,西药治疗口腔异味容易产生耐药性,且常常导致口腔异味反复发作,也有较大可能产生副作用,中医认为,引起口腔异味的原因虽然复杂,但主要是胃火炽盛造成胃阴不足,胃肠功能紊乱,消化不良等引起口气上攻及风火或湿热所致。但现有中医治疗口腔异味药物的药味重、口感差,令患者十分苦恼。
发明内容
本发明的目的在于:提供一种清除口腔异味效果好、药味轻、口感佳且无毒副作用的玫瑰花咀嚼片及其制备方法。
为了实现上述目的,本发明采用如下技术方案:
一种清除口腔异味的玫瑰花咀嚼片,包含有效成分和辅料/助剂,所述有效成分包含重量份的玫瑰花水提物4.2-5.7份、茯苓水提物2-2.6份、金银花水提物2-2.6份、白菊花水提物0.3-0.5份、蒲公英水提物1.2-1.5份、山楂水提物2.5-3.2份、绿茶水提物0.5-0.6份、香菇多糖0.5-1.2份、甘草水提物1.5-2份、粳米3.3-4.1份。
优选地,所述有效成分还包含重量份的蜂蜜0.3-1份。
优选地,所述有效成分包含重量份的玫瑰花水提物5份、茯苓水提物2.4份、金银花水提物2.4份、白菊花水提物0.4份、蒲公英水提物1.8份、山楂水提物3份、绿茶水提物0.6份、香菇多糖0.6份、甘草水提物1.8份、蜂蜜0.5份、粳米3.5份。
优选地,所述辅料/助剂是大豆分离蛋白粉、麦芽糊精、脱味羊奶中的一种或多种的混合。
优选地,所述的清除口腔异味的玫瑰花咀嚼片,所述脱味羊奶是在羊奶中加入3%重量比杏仁煎煮20-30分钟后得到的羊奶。
与现有技术相比,本发明的有益效果在于:
本发明清除口腔异味的玫瑰花咀嚼片中,玫瑰花有清新口气、柔肝醒胃、舒气活血作用;茯苓有益脾和胃、利水泻火、消积、抗菌作用;白菊花有健脾和胃、杀菌消炎作用;蒲公英有补脾和胃、泻火、杀菌作用;山楂有消食开胃、行气散瘀、抗菌作用;香菇多糖有益气健脾、补虚扶正作用;甘草有泄胃火、肺火和行气作用;粳米补脾和胃作用并作有效成分的载体;蜂蜜有杀菌消毒、润滑肠胃、助消化作用,因而上述组分共同配合具有消食和胃、泄胃火及助消化的功效,从而改善胃火炽盛造成胃肠功能紊乱、消化不良的问题;金银花有清热解毒、凉散风热,杀菌作用;绿茶含儿茶素,其有助消化、消炎杀菌、除口臭的作用;该两种组分与茯苓、白菊花、蒲公英、山楂、蜂蜜配合具有杀菌、抗菌作用,从而解决口腔细菌滋生问题;同时金银花与白菊花配合可清热泻火。因而,本发明玫瑰花咀嚼片能够有效改善胃火炽盛造成胃肠功能紊乱、消化不良及口腔细菌滋生问题,达到清除口腔异味的作用。并且该咀嚼片采用药食同源材料制成,尤其是玫瑰花的清香可快速掩盖口腔异味,故有起效快、药味淡、效果好、安全无副作用及不产生耐药性的优点。
具体实施方式
下面结合具体实施例对本发明的技术方案和效果作进一步阐述。应当理解,以下所述实施例仅用于说明和解释本发明,并不用于限定本发明的权利范围。
以下实施例中,所用药材均为2015版药典所收载的药材,经鉴定,各项指标均符合规定;所述辅料/助剂为市售的常规产品。
实施例1
一种清除口腔异味的玫瑰花咀嚼片,由18-25%有效成分和82-75%辅料/助剂制成,其组分及用量如下表1所示。
表1-清除口腔异味的玫瑰花咀嚼片组分及用量
所述脱味羊奶是在羊奶中加入3%重量比杏仁煎煮20-30分钟得到的羊奶。
按照上述组分及用量备料,然后采用如下步骤制备成:
1)制备所述水提物:称取各组分用量120倍的原料,分别加入相当于其重量10倍蒸馏水,回流煎煮2次(每次2小时)及过滤后,合并滤液,得各组分水提液;将各组分水提液混合均匀后,减压浓缩至相对密度为1.2,得浓缩液;浓缩液经离心得清液;清液浓缩至相对密度1.4,得水提物;
2)制备辅料/助剂:称取大豆分离蛋白粉、麦芽糊精和脱味羊奶,混合并兑适量水后,在温度60℃拌和均匀,使大豆分离蛋白粉和麦芽糊精均匀分散在脱味羊奶中,浓缩至相对密度1.0,得辅料/助剂;
3)粳米研磨:称取粳米,蒸熟、干燥后粉碎并过30目筛,得粳米粉;
4)调配:将所述粳米粉、水提物和香菇多糖加入所述辅料/助剂中,在60℃恒温下拌和均匀,得浸膏;
4)成型及包装:将所述浸膏送入压片机中压制并干燥成0.5g/片,经检验合格后包装。
实施例2
由18-25%有效成分和82-75%辅料/助剂制成,其组分及用量如下表1所示。
表2-清除口腔异味的玫瑰花咀嚼片组分及用量
所述脱味羊奶是在羊奶中加入3%重量比杏仁煎煮20-30分钟得到的羊奶。
按照上述组分及用量备料,然后采用如下步骤制备成:
1)制备所述水提物:称取各组分用量120倍的原料,分别加入相当于其重量10倍蒸馏水,回流煎煮2次(每次2小时)及过滤后,合并滤液,得各组分水提液;将各组分水提液混合均匀后,减压浓缩至相对密度为1.2,得浓缩液;浓缩液经离心得清液;清液浓缩至相对密度1.4,得水提物;
2)制备辅料/助剂:称取大豆分离蛋白粉、麦芽糊精和脱味羊奶,混合并兑适量水后,在温度60℃拌和均匀,使大豆分离蛋白粉、麦芽糊精均匀分散在脱味羊奶中,浓缩至相对密度1.0,得辅料/助剂;
3)粳米研磨:称取粳米,蒸熟、干燥后粉碎并过30目筛,得粳米粉;
4)调配:将所述粳米粉、水提物、香菇多糖、蜂蜜加入所述辅料/助剂中,在60℃恒温下拌和均匀,得浸膏;
4)成型及包装:将所述浸膏送入压片机中压制并干燥成0.5g/片,经检验合格后包装。
1、毒性试验
1.1急性毒性试验
选用10只健康母鼠,按每日3mg/kg母鼠剂量喂食本发明黄芪颗粒,在正常喂养状况下,连续喂养7日,未发现母鼠发生急性毒性现象,也未发现其它不良状况,表明本发明黄芪颗粒无急性毒性;
1.2长期毒性试验
选用10只健康母鼠,按每日1mg/只母鼠剂量喂食本发明黄芪颗粒,在正常喂养状况下,连续喂养30日,未发现母鼠发生毒性现象,也未发现其它不良状况,表明本发明黄芪颗粒无长期毒性。
经毒性试验确定本发明玫瑰花咀嚼片安全可靠后,进行临床测试:
2.1一般资料
口腔异味患者18例,其中男10例,女8例;年龄15-56岁,平均32岁。所有患者均无口腔疾病,且口腔卫生习惯良好,临床主要表现为口臭,并伴有嗳气、便秘、消化不良等症。
2.2治疗方法
所有患者服用本发明的玫瑰花咀嚼片,每日3次,每次1.5g,早、中、晚各服1次,7天为1个疗程,连服2个疗程。
2.3口腔异味判断方法
用直径1cm、长10cm的医用塑料管,一端放于受试者口部,一端放于检查者鼻部,让受试者吐气。
2.4症状积分评价标准:
总积分=主症积分×70%+次症积分×30%。
①主症评分,即口臭评分,采用八重恒健提出的鼻诊法,口臭症状主观评分为(0-10分),其中,0分:察觉不到气味;2分:勉强可以察觉到气味,若有若无;4分:轻微但可明确察觉;6分:中等臭味,十分明确的口臭;8分:强烈臭味,但可忍受;10分:极强的不能忍受的恶臭。
②次症评分:便秘、嗳气、肚痛等症状按无、轻、中、重来进行评分为0-3分,0分:无症状;1分:轻度,无明显症状;2分:中度,症状明显,可以忍受;3分:重度,症状严重,不能忍受。
2.5疗效评价:参照《中医病症诊断疗效标准》制定。
痊愈:治疗后总积分较治疗前下降≥90%;
显效:治疗后总积分较治疗前下降≥60-89%;
有效:治疗后总积分较治疗前下降≥30-59%;
无效:治疗后总积分较治疗前下降<30%。
2.6治疗结果,见下表3
表3-口腔异味治疗疗效
病例 | 痊愈 | 显效 | 有效 | 无效 | 总有效率(%) |
18 | 5 | 8 | 4 | 1 | 94.4 |
通过表3可知,本发明玫瑰花咀嚼片治疗口腔异味效果显著,总有效率高达94.4%,且没有出现任何临床不良反应。此外,由于本发明咀嚼片重用玫瑰花,且所用药物气味较淡,因而受试者喜欢咀嚼食用,食用后对烟味、大蒜、大葱等刺激性气味掩盖效果良好。
Claims (6)
1.一种清除口腔异味的玫瑰花咀嚼片,包含有效成分和辅料/助剂,其特征在于:所述有效成分包含重量份的玫瑰花水提物4.2-5.7份、茯苓水提物2-2.6份、金银花水提物2-2.6份、白菊花水提物0.3-0.5份、蒲公英水提物1.2-1.5份、山楂水提物2.5-3.2份、绿茶水提物0.5-0.6份、香菇多糖0.5-1.2份、甘草水提物1.5-2份、粳米3.3-4.1份。
2.如权利要求1所述的清除口腔异味的玫瑰花咀嚼片,其特征在于:所述有效成分中还包含重量份的蜂蜜0.3-1份。
3.如权利要求2所述的清除口腔异味的玫瑰花咀嚼片,其特征在于:所述有效成分包含重量份的玫瑰花水提物5份、茯苓水提物2.4份、金银花水提物2.4份、白菊花水提物0.4份、蒲公英水提物1.8份、山楂水提物3份、绿茶水提物0.6份、香菇多糖0.6份、甘草水提物1.8份、蜂蜜0.5份、粳米3.5份。
4.如权利要求1-3任一所述的清除口腔异味的玫瑰花咀嚼片,其特征在于:所述辅料/助剂是大豆分离蛋白粉、麦芽糊精、脱味羊奶中的一种或多种的混合。
5.如权利要求4所述的清除口腔异味的玫瑰花咀嚼片,其特征在于:所述脱味羊奶是在羊奶中加入3%重量比杏仁煎煮20-30分钟后得到的羊奶。
6.一种根据权利要求2所述的清除口腔异味的玫瑰花咀嚼片的制备方法,其特征在于其步骤如下:
1)制备所述水提物:称取各组分用量120倍的原料,分别加入相当于其重量10倍蒸馏水,回流煎煮2次(每次2小时)及过滤后,合并滤液,得各组分水提液;将各组分水提液混合均匀后,减压浓缩至相对密度为1.2,得浓缩液;浓缩液经离心得清液;清液浓缩至相对密度1.4,得水提物;
2)制备辅料/助剂:称取大豆分离蛋白粉、麦芽糊精和脱味羊奶,混合并兑适量水后,在温度60℃拌和均匀,使大豆分离蛋白粉、麦芽糊精均匀分散在脱味羊奶中,浓缩至相对密度1.0,得辅料/助剂;
3)粳米研磨:称取粳米,蒸熟、干燥后粉碎并过30目筛,得粳米粉;
4)调配:将所述粳米粉、水提物、香菇多糖、蜂蜜加入所述辅料/助剂中,在60℃恒温下拌和均匀,得浸膏;
4)成型及包装:将所述浸膏送入压片机中压制并干燥成0.5g/片,经检验合格后包装。
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