CN110645752A

CN110645752A - Realize temperature-reducing and heat-preserving device of temperature subregion

Info

Publication number: CN110645752A
Application number: CN201910948051.XA
Authority: CN
Inventors: 李�浩; 牛永杰; 梁波
Original assignee: Suzhou Bei Kang Medical Devices Co Ltd
Current assignee: Suzhou Bei Kang Medical Devices Co Ltd
Priority date: 2019-10-08
Filing date: 2019-10-08
Publication date: 2020-01-03

Abstract

The invention relates to a cooling and heat-preserving device for realizing temperature partition, which comprises: the insulation box body comprises a first cabin body and a second cabin body which are mutually communicated through a communication port; the first cabin body is provided with a partition structure higher than the communication port, the partition structure partitions the first cabin body into an upper cabin body and a lower cabin body along the height direction, and the partition structure is provided with a mechanism movement port for communicating the upper cabin body and the lower cabin body; a cooling module arranged along the height direction is arranged in the second cabin body. The technical effects are as follows: utilize the cooling module to provide a low temperature access environment for biological sample relatively to guarantee biological sample's biological activity, utilize first cabin body, second cabin body and cut off the structure and carry out the temperature subregion with the insulation box, make automatic system be in the higher region of temperature relatively, thereby make automatic system's mechanical component and electrical component can be in the higher region of temperature, need not to use special material and lubricated mode, reduce manufacturing cost and maintenance cost.

Description

Realize temperature-reducing and heat-preserving device of temperature subregion

Technical Field

The invention relates to the technical field of biological sample storage, in particular to a cooling and heat-insulating device for realizing temperature partition.

Background

Biological samples are typically stored in a deep cryogenic environment, and access to the biological samples may be handled by an automated system. The automatic system mainly comprises a mechanical part and an electrical part, and if the conventional mechanical part is in a deep low-temperature environment for a long time, the problems of precision reduction, lubricating grease solidification, kinematic pair blocking caused by material shrinkage, material embrittlement and the like can occur; the working temperature of the electric parts is basically between 40 ℃ below zero and 60 ℃, and the electric parts are difficult to use in a deep low-temperature environment for a long time. Therefore, in order to realize long-term stable and reliable operation of an automation system in a cryogenic environment, it is necessary to select a special material and a special lubrication method, which leads to high cost.

Disclosure of Invention

Therefore, it is necessary to provide a cooling and heat-insulating device for realizing temperature zones, aiming at the problem of high cost of an automation system.

A cooling and heat-preserving device for realizing temperature partition comprises: the insulation box body comprises a first cabin body and a second cabin body which are mutually communicated through a communication port; the first cabin body is provided with a partition structure higher than the communication port, the partition structure partitions the first cabin body into an upper cabin body and a lower cabin body along the height direction, and the partition structure is provided with a mechanism moving port communicating the upper cabin body and the lower cabin body; and a cooling module arranged along the height direction is arranged in the second cabin body.

The technical scheme at least has the following technical effects: this technical scheme provides a cooling heat preservation device who is used for acceping automatic system's realization temperature subregion, and at automatic access in-process, sets up automatic system in the heat-preserving box. Utilize the cooling module to provide a low temperature access environment for biological sample relatively, in order to guarantee biological sample's biological activity, utilize the first cabin body and the second cabin body that communicate each other, it carries out the temperature subregion with the insulation box to cut off the structure, make automatic system be in the higher region of temperature relatively, and make biological sample be in the lower region of temperature relatively, thereby make automatic system's mechanical component and electrical component can be in the higher region of temperature, guarantee automatic system's operational reliability, improve automatic system's life, need not to use special material and lubricated mode, reduce manufacturing cost and maintenance cost.

In one embodiment, the mechanism movement port is provided with a seal capable of sealing upon movement of the mechanism.

In one embodiment, the box body wall of the insulation box body comprises a shell, an insulation layer connected with the shell and a support framework embedded in the insulation layer.

In one embodiment, a first sealing cover is arranged at the top of the first cabin body in the height direction, and the first sealing cover is communicated with the upper cabin body.

In one embodiment, a second sealing cover is arranged at the top of the second cabin body along the height direction, and the second sealing cover is communicated with the second cabin body.

In one embodiment, the second sealing cover is provided with an air outlet at the top in the height direction, and the air outlet is provided with a heating module located in the second sealing cover.

In one embodiment, the cooling module comprises a frame, a plurality of mesh plates arranged on the frame, a porous plate clamped between the two mesh plates, and a spray pipe arranged on the frame.

In one embodiment, the bottom of the mesh plate in the height direction is provided with a liquid accumulation plate, and the projection profile of the liquid accumulation plate on the bottom of the second cabin is larger than the projection profile formed by the mesh plates.

In one embodiment, the cooling and heat-preserving device further comprises a control board, an electromagnetic valve electrically connected with the control board, and a temperature probe electrically connected with the control board, wherein the electromagnetic valve is arranged on a liquid inlet of the spray pipe extending out of the second cabin body, and the temperature probe is arranged in the heat-preserving box body.

In one embodiment, the cooling module extends from the bottom of the second chamber to a position higher than the communication port.

Drawings

FIG. 1 is a schematic structural view of a cooling and heat-preserving apparatus according to an embodiment of the present invention;

FIG. 2 is a top view of the cooling and warming device shown in FIG. 1;

FIG. 3 is a schematic view of a temperature zone of the cooling and heat-preserving device shown in FIG. 1;

FIG. 4 is a schematic structural diagram of a cooling module according to an embodiment of the present disclosure;

FIG. 5 is a schematic structural view of the cooling module shown in FIG. 4 with the frame and the mesh plate removed;

FIG. 6 is a schematic structural view of a shower pipe in the cooling module shown in FIG. 4;

fig. 7 is a partial schematic view of the shower and the first temperature probe of the cooling module shown in fig. 4.

Wherein:

10. cooling and heat-preserving device 100, heat-preserving box 102 and shell

104. Insulating layer 106, support framework 110 and first cabin body

112. Partition structure 113, mechanism movement port 114, and seal member

115. Transparent plate 116, upper cabin 118 and lower cabin

120. Second cabin 130, communicating port 140 and cooling module

141. Frame 142, mesh plate 143, perforated plate

144. Spray pipe 145, spray holes 146 and liquid loading disc

147. Liquid inlet 148, electromagnetic valve 150 and first temperature probe

151. Temperature detection point 152, second temperature probe 154, third temperature probe

156. A fourth temperature probe 160, a first sealing cover 170, a second sealing cover

172. Air outlet 174, heating module 111 and isolation structure

A. Deep low temperature zone B, low temperature zone C, sub-low temperature zone

D. Room temperature zone

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Referring to fig. 1 to 3, an embodiment of the present invention provides a cooling and heat preserving apparatus 10 for realizing temperature partition, including: a heat-insulating box 100 including a first chamber 110 and a second chamber 120 which are communicated with each other through a communication port 130; the first cabin body 110 is provided with a partition structure 112 higher than the communication port 130, the partition structure 112 partitions the first cabin body 110 into an upper cabin body 116 and a lower cabin body 118 along the height direction, and the partition structure 112 is provided with a mechanism movement port 113 communicating the upper cabin body 116 and the lower cabin body 118; a cooling module 140 is disposed in the second cabin 120 along the height direction.

It should be noted that the "height direction" mentioned herein is defined by the placement posture as shown in fig. 1, and the adjustment of the placement posture does not affect the actual structural layout. The cooling and heat preserving device 10 provided by the embodiment of the invention is used for providing a relatively low-temperature environment for the biological sample and a relatively high-temperature environment for the automatic system during automatic access, so that the biological activity of the biological sample and the operation reliability of the automatic system can be ensured.

As shown in fig. 1, the thermal insulation box 100 includes a first chamber 110 and a second chamber 120 which are connected to each other. As a specific scheme, an isolation structure 111 made of thermal insulation material is disposed in the thermal insulation box 10, and the isolation structure 111 divides the space in the thermal insulation box 10 into a first cabin 110 and a second cabin 120. The isolation structure 111 is disposed along the vertical direction, and a gap is formed between the isolation structure 111 and the bottom of the thermal insulation box 10, so as to form a communication port 130 for communicating the first cabin 110 with the second cabin 120. In other aspects, the communication port 130 may be formed by the isolation structure 111.

The first chamber 110 and the second chamber 120 are separated by an isolation structure 111 formed of an insulation material and are communicated through a communication port 130, that is, the isolation structure 111 does not completely separate the first chamber 110 from the second chamber 120. The communication port 130 may be an opening formed from the bottom of the self-insulation box 100 to the isolation structure 111, an opening formed from a position at a predetermined distance from the bottom of the self-insulation box 100 to the isolation structure 111, or an opening formed from the isolation structure 111 at a predetermined distance from the bottom of the self-insulation box 100. With such an arrangement, the low-temperature gas formed by the cooling module 140 located in the second cabin 120 can be transmitted into the first cabin 110 through the communication port 130, so that the space near the communication port 130 in the first cabin 110 is in a deep low-temperature region, the space relatively far away from the communication port 130 to the partition structure 112 is in a low-temperature region, and the space in the upper cabin 116 is in a secondary low-temperature region.

The first cabin 110 is divided into an upper cabin 116 and a lower cabin 118 by a partition structure 112, the partition structure 112 is provided with a mechanism moving port 113, and the partition structure 112 is arranged along a horizontal direction. The automatic system comprises at least a tube picking mechanism and a basket lifting mechanism, in this embodiment, the tube picking mechanism is at least partially located in the upper chamber 116 and at least partially located in the lower chamber 118, and the tube picking mechanism extends out of the mechanism moving port 113 to perform an access operation on the biological sample, for example, a clamping mechanism or a suction mechanism is provided in the lower chamber 118 for clamping or sucking the cryopreserved tube containing the biological sample.

The second cabin 120 is provided with a cooling module 140 for generating and maintaining a low temperature, and the cooling module 140 may be directly fixed to the inner wall of the second cabin 120, or directly fixed to the bottom of the second cabin 120, without contacting the inner wall of the second cabin 120. The basket mechanism is disposed in the second chamber 120, and is used to take out the freezing tray with the freezing tubes from the storage device, and the core components of the basket mechanism are disposed on the top of the second chamber 120, such as a motor, and other transmission components, such as a conveyor belt and a rack, substantially span the cooling module 140 in height. The freezing tray or the freezing pipe can be transferred into the first chamber body 110 through the communication port 130 to perform a pipe picking operation.

The partition structure 112 is made of a thermal insulation material, and may specifically be Polyisocyanurate (PIR), Polyurethane (PUR), expanded polypropylene (EPP), polystyrene foam (EPS), extruded polystyrene foam (XPS), aerogel or vacuum insulation panel, or the like. The partition structure 112 may be disposed at a suitable height position in the first chamber 110 according to the size of the automation system. For example, the partition structure 112 is disposed at the 2/3 height or the 1/2 height of the first cabin 110, which can provide a larger accommodating space for the tube-picking mechanism, so that the tube-picking mechanism is more in a higher temperature environment. Correspondingly, the height of the communication port 130 may be 1/2 or 1/3 of the lower chamber 118, so as to provide a sufficient transfer space for the freezing tray or the freezing pipe.

The cooling module 140 can form low-temperature gas, and different temperature regions can be formed in spaces with different distances by using the transfer and diffusion of the low-temperature gas. Deep low-temperature regions can be formed in the space occupied by the cooling module 140, low-temperature regions can be formed in the space far away from the cooling module 140, low-temperature gas can be transferred into the first cabin 110 through the communication port 130, and different temperature regions can be formed according to the distance. Because the incubator body 100 has a certain height, the basket lifting mechanism can lift the cryopreservation tray to a higher position, and in order to ensure the biological activity of the biological sample, the cooling module 140 is arranged along the height direction, that is, the span in the height direction is relatively large. It is understood that the cooling module 140 may extend from the bottom of the second chamber 120 in the height direction, or may extend from a position at a certain distance from the bottom of the second chamber 120 in the height direction, which is not limited herein. Since the first cabin 110 and the second cabin 120 are separated by the isolation structure formed by the thermal insulation material, the thermal insulation effect is better, and the influence of the cooling module 140 on the space far away from the communication port 130 in the upper cabin 116 and the lower cabin 118 is lower, so the temperature partition in the second cabin 120 is mainly influenced by the height of the cooling module 140.

For example, if the cryopreserving plate can be elevated to a higher position within the second compartment 120, the cooling module 140 is designed to extend from the bottom of the second compartment 120 to a height position above the partition structure 112. As shown in fig. 3, since the communication port 130 is closer to the cooling module 140, a deep low-temperature zone a is formed in the lower cabin 118 in a height range from the bottom of the lower cabin 118 to the stop of the communication port 130, a low-temperature zone B is formed in a height range from the stop position of the communication port 130 to the partition structure 112, and a sub-low-temperature zone C is formed in a height range of the upper cabin 116; in the second cabin 120, a deep low temperature region a is formed in a height range from the bottom of the second cabin 120 to a certain distance higher than the cooling module 140, and a low temperature region B is formed in the remaining height range. It will be appreciated that the boundaries of the different temperature zones described above allow for fluctuations.

The high and low temperature grades are as follows: the deep low-temperature area A is less than the low-temperature area B is less than the secondary low-temperature area C is less than the room-temperature area D. According to the arrangement, the automatic system is not required to be completely in a deep low-temperature environment, mechanical parts and electrical parts forming the automatic system are more located in the low-temperature area B and the secondary low-temperature area C, the problems of clamping of a kinematic pair, embrittlement of materials and the like caused by precision reduction, solidification of lubricating grease and material shrinkage are reduced, the temperature of a use environment is improved, the service lives of the mechanical parts and the electrical parts are prolonged, the automatic system can reliably run for a long time, special materials and special lubricating modes are not required to be adopted, and the manufacturing production cost and the maintenance cost are reduced.

The technical scheme at least has the following technical effects: this technical scheme provides a cooling heat preservation device 10 that realizes the temperature subregion for accommodating automated system, and at automatic access in-process, sets up automated system in insulation box 100. Utilize cooling module 140 to provide a relatively microthermal access environment for biological sample, in order to guarantee biological activity of biological sample, utilize first cabin body 110 and second cabin body 120 that communicate each other, it carries out the temperature subregion to cut off structure 112 with insulation box 100, make the automation system be in the region that the temperature is relatively higher, and make biological sample be in the region that the temperature is relatively lower, thereby make the mechanical component and the electrical component of automation system can be in the region that the temperature is higher, guarantee automation system's operational reliability, improve automation system's life, need not to use special material and lubrication mode, reduce manufacturing cost and maintenance cost.

In some embodiments, the cooling module 140 extends from the bottom of the second nacelle 120 to a position higher than the communication port 130. When the basket lifting mechanism lifts the target freezing storage disc to the height of the communication port 130, the tube picking mechanism directly or indirectly picks out the freezing storage tube in the freezing storage disc, so that the height range of the communication port 130 is a biological sample transfer area, a low-temperature storage and taking environment needs to be provided for the biological sample in the height range, and therefore, the height of the cooling module 140 is set to be higher than that of the communication port 130.

With continued reference to fig. 1 and 2, in some embodiments, the mechanism movement port 113 is provided with a seal 114 capable of sealing upon movement of the mechanism. Since the pipe picking mechanism is inserted into the mechanism moving port 113, a gap is left between the pipe picking mechanism and the mechanism moving port 113, and at this time, cold air easily enters the upper cabin 116 from the gap, thereby affecting the temperature partitioning effect of the upper cabin 116 and the lower cabin 118. For this purpose, a sealing member 114 capable of sealing when the tube raising mechanism moves is provided at the mechanism movement port 113. For example, the mechanism moving port 113 may be covered with a cover member like a bellows cover. For example, an annular seal ring may be used which surrounds the mechanism movement port 113 once and contacts the pipe lifting mechanism, and the pipe lifting mechanism can perform a certain sealing function by deformation of the pipe lifting mechanism itself in the reciprocating direction during reciprocation.

With continued reference to fig. 2, in some embodiments, the partition structure 112 further comprises a transparent plate 115 for transmitting light between the upper compartment 116 and the lower compartment 118. The transparent plate 115 is made of a high light transmittance material, and may have a thickened, hollow or vacuum structure to ensure a thermal insulation effect. A camera, a camera or an illumination lamp can be installed on the upper portion of the transparent plate 115 to photograph or illuminate a working scene in the lower chamber 118.

With continued reference to fig. 1 and 2, in some embodiments, the wall of the insulated cabinet 100 includes an outer shell 102, an insulating layer 104 coupled to the outer shell 102, and a support framework 106 embedded in the insulating layer 104. The housing 102 is made of a rigid material with low thermal conductivity to ensure the structural strength and the shape stability of the thermal insulation box 100, such as glass fiber reinforced plastic, teflon, Acrylonitrile Butadiene Styrene (ABS), etc. The insulating layer 104 may be made of Polyisocyanurate (PIR), Polyurethane (PUR), expanded polypropylene (EPP), polystyrene foam (EPS), extruded polystyrene foam (XPS), aerogel, or vacuum insulation board, etc. In order to further improve the structural strength and the shape stability of the thermal insulation box 100, a plurality of supporting frameworks 106 are embedded in the thermal insulation layer 104, and the supporting frameworks 106 are mainly positioned at the corners so as to reduce the deformation of the thermal insulation box 100. To reduce the overall weight, the support frame 106 may be made of a non-metallic material.

With continued reference to fig. 1 and 2, in some embodiments, a first sealing cover 160 is disposed at a top portion of the first cabin 110 along the height direction, and the first sealing cover 160 is in communication with the upper cabin 116. In order to enrich the temperature zone of the thermal insulation box 100 and enable the mechanical components and the electrical components of the automation system to be located at relatively high temperature positions, a first sealing cover 160 communicated with the upper cabin 116 is further arranged on the top of the first cabin 110, the first sealing cover 160 is made of a thin plate material with good heat conductivity, and the arrangement is such that the temperature inside the first sealing cover 160 is close to the external room temperature, and a room temperature zone D is formed. In this case, the mechanical and electrical components of the automation system can be moved upward relatively to be located more in the room temperature region D, thereby further improving the operational reliability of the automation system. In addition, the partition between the upper cabin 116 and the first sealing cover 160 is made of the same insulating material as the insulating layer 104.

With continued reference to fig. 1 and 2, in some embodiments, a second sealing cover 170 is disposed at the top of the second cabin 120 along the height direction, and the second sealing cover 170 is in communication with the second cabin 120. In order to enrich the temperature zones of the thermal insulation box 100 and enable the mechanical components and the electrical components of the automation system to be located at relatively high temperature positions, a second sealing cover 170 communicated with the second cabin 120 is further arranged at the top of the second cabin 120, the second sealing cover 170 is made of a thin plate material with good heat conduction performance, and the temperature in the first sealing cover 160 is close to the external room temperature, so that a room temperature zone D is formed. In this case, the mechanical and electrical components of the automation system can be moved upward relatively to be located more in the room temperature region D, thereby further improving the operational reliability of the automation system. In addition, the partition between the second cabin 120 and the second sealing cover 170 is made of the same insulating material as the insulating layer 104.

Further, an air outlet 172 is formed at the top of the second sealing cover 170 along the height direction, and a heating module 174 located in the second sealing cover 170 is disposed at the air outlet 172. The liquid nitrogen vaporization cooling is taken as an example for explanation. Since the temperature lowering module 140 continuously supplies liquid nitrogen, which is continuously vaporized into liquefied gas, in order to balance the gas inside and outside the heat-insulating case 100, it is necessary to discharge the liquefied gas out of the heat-insulating case 100. For this purpose, an air outlet 172 is opened at the top of the second sealing cover 170, and a closure cap for closing the rotational connection of the air outlet 172 is provided at the air outlet 172, that is, the closure cap can be opened or closed. Because the liquid nitrogen is vaporized and evaporated quickly to generate positive pressure to push the gas in the thermal insulation box body 100 to flow, the sealing cover can be pushed open automatically to exhaust when the liquefied gas is more, and the sealing cover can be closed automatically under the action of gravity after the liquefied gas is discharged in time. In order to prevent the air outlet 172 from condensation or frost formation, a heater module 174 is further provided at the air outlet 172 so that the liquefied gas can be smoothly discharged. The heating module 174 may be resistance heating, induction heating, arc heating, electron beam heating, infrared heating, dielectric heating, or the like.

In a traditional deep low temperature refrigeration mode, electric energy is generally adopted as energy, and a multi-stage compressor refrigeration or liquefied gas spray refrigeration is adopted. The multistage compressor usually compresses two working media, and the purpose of appointing the evaporation temperature is achieved after heat exchange is carried out in the intermediate heat exchanger by utilizing the different physical characteristics of the two working media, so that the pressure ratio of the compressor borne by the compressor is very large, the refrigeration problem easily occurs in the long-term operation of a refrigeration system, the stability and the reliability of deep low-temperature refrigeration equipment are lower, the refrigeration speed is lower, and the energy consumption is higher. The liquefied gas spray refrigeration can realize rapid refrigeration, but the liquid nitrogen is usually in a gas-liquid mixed state in a pipeline, so that the temperature reduction process is unstable, and when the temperature is reduced to a certain temperature, the vaporization speed is reduced, and liquid accumulation is easy to generate; if the liquefied gas is firstly vaporized into low-temperature gas outside the heat-insulating cabin and then is sent into the heat-insulating cabin, although no accumulated liquid is generated, the utilization rate of the liquefied gas is reduced.

To this end, with continued reference to fig. 4 to 6, in some embodiments, the cooling module 140 includes a frame 141, a plurality of mesh plates 142 mounted on the frame 141, a porous plate 143 sandwiched between two mesh plates 142, and a shower 144 mounted on the frame 141. The liquid nitrogen vaporization cooling is taken as an example for explanation, but is not limited to liquid nitrogen spraying. Liquid nitrogen is sprayed onto the porous plate 143 through the spraying pipe 144, the porous plate 143 can accelerate evaporation of the liquid nitrogen, the liquid nitrogen can generate positive pressure through rapid evaporation, and gas in the heat preservation box body 100 is pushed to flow, so that rapid refrigeration is realized. The liquefied gas is transferred to the first tank 110 through the communication port 130, and the temperature division layout as shown in fig. 3 is finally formed.

The frame 141 is used to support the mesh plate 142, the perforated plate 143 and the shower 144 so that they are combined into a single module. The mesh plate 142 is fixed to the frame 141 and used for supporting and clamping the mesh plate 143, and the mesh plate 142 can facilitate the flow of liquid nitrogen and liquefied gas relative to the solid plate, so that the refrigerating speed is increased. The porous plate 143 is made of porous material, such as open-cell copper foam, open-cell aluminum foam, melamine sponge, open-cell foam glass, aluminum silicate fiber, etc., or can be replaced by an evaporator. The porous plate 143 can increase the contact area between the liquid nitrogen and the liquefied gas, and accelerate the cooling rate. The mesh plate 142 and the perforated plate 143 can accelerate the vaporization speed and reduce the generation of effusion. Since the temperature lowering module 140 is disposed in the thermal insulation case 100, the utilization rate of liquefied gas is improved.

Specifically, at least one perforated plate 143 is interposed between two perforated plates 142, for example, as shown in fig. 4 and 5, four perforated plates 142 are provided, two perforated plates 142 are one set, each set of perforated plates 142 is interposed with two perforated plates 143 arranged in the height direction, and the four perforated plates 142 are locked by a frame 141. The spray pipe 144 includes a main spray pipe and sub spray pipes, the main spray pipe is used for conveying liquid nitrogen from the outside to the inside of the thermal insulation box 100, the main spray pipe is communicated with the plurality of sub spray pipes through a multi-way pipe, and the sub spray pipes are bent, so that a part of the sub spray pipes are uniformly distributed above each porous plate 143. One side of the sub-spray pipes facing the porous plate 143 is provided with a plurality of spray holes 145 for spraying.

Further, the bottom of the mesh plate 142 in the height direction is provided with a liquid accumulation plate 146, and the projection profile of the liquid accumulation plate 146 on the bottom of the second chamber 120 is larger than the projection profile formed by the plurality of mesh plates 142. The drip tray 146 may be used to store liquid nitrogen that has not been vaporized on the perforated plate 143 so that the portion of liquid nitrogen is vaporized within the drip tray 146. Since the plurality of mesh plates 142 surround the projection profile of the cooling module 140 on the bottom of the second chamber 120, in order to ensure that the liquid nitrogen which is not vaporized can be collected by the liquid accumulation disk 146, the projection profile of the liquid accumulation disk 146 on the bottom of the second chamber 120 is set to be larger than the projection profile formed by the plurality of mesh plates 142.

Further, the cooling and heat preserving device 10 further comprises a control board, an electromagnetic valve 148 electrically connected with the control board, and a temperature probe electrically connected with the control board. The spraying pipe 144 includes a liquid inlet 147 extending out of the second chamber 120, and a solenoid valve 148 is disposed at the liquid inlet 147 for controlling whether to supply liquid nitrogen. The temperature probe is disposed in the thermal insulation box 100 and used for detecting the temperature condition in the thermal insulation box 100. In this embodiment, the liquid nitrogen is supplied in a sufficient amount from a liquid nitrogen supply source located outside the incubator body 100. When liquid nitrogen needs to be continuously supplied, the electromagnetic valve 148 keeps an open state, and the liquid nitrogen is continuously conveyed into the heat preservation box body 100; when the supply of liquid nitrogen needs to be stopped, the solenoid valve 148 is closed and the liquid nitrogen cannot be delivered into the insulated cabinet 100.

Because the liquid nitrogen is usually in a gas-liquid mixed state in the pipeline, the flow control is not easy to realize, and the temperature reduction process is unstable. For this purpose, a plurality of temperature probes at different positions may be provided in the incubator 100. For example, as shown in fig. 1 and 7, four temperature probes are provided at different positions in the heat-insulating case 100. The shower pipe 144 is provided with a first temperature probe 150 in the second chamber 120, a second temperature probe 152 and a third temperature probe 154 are provided in the second chamber 120 at intervals in the height direction, and a fourth temperature probe 156 is provided in the lower chamber 118. According to the arrangement, the liquid nitrogen flow is controlled by utilizing multiple temperature detection, the controllability of the cooling process is improved, and the stability of the liquid nitrogen cooling process is improved.

Specifically, the first temperature probe 150, the second temperature probe 152, the third temperature probe 154, the fourth temperature probe 156 and the solenoid valve 148 are electrically connected to a control board, and the control board can control the opening or closing of the solenoid valve 148 according to the detection results of the different temperature probes.

As shown in FIG. 7, a first temperature probe 150 is located in the delivery portion of the shower 144, i.e., the primary nozzles as previously described, relatively close to the liquid inlet 147. The first temperature probe 150 is inserted from top to bottom, and the temperature detection point 151 is located near the bottom inside the tube. Because the liquid nitrogen in the tube body is not full of the whole tube body, the liquid nitrogen in the tube body has a certain height during horizontal conveying, but the height is smaller than the inner diameter of the tube body, and because the temperature of the liquid nitrogen is lower than the temperature of the vaporized nitrogen, when the vaporization speed of the liquid nitrogen is slow and the liquid level of the liquid nitrogen in the tube body rises to the height of the temperature detection point 151, the first temperature probe 150 can detect the sudden drop (-196 ℃) of the temperature, and therefore, the vaporization condition of the liquid nitrogen can be detected by using the temperature detection point 151.

As shown in fig. 1, the second temperature probe 152 is located on the top of the liquid collecting tray 146 for detecting the vaporization of the liquid nitrogen in the liquid collecting tray 146, and correspondingly, the second temperature probe 152 can detect the temperature of the deep low temperature region a. The third temperature probe 154 is located at a position adjacent to the main nozzles of the shower pipe 144 in the second chamber 120 for detecting the temperature at a higher position in the second chamber 120, and correspondingly, the third temperature probe 154 can detect the temperature of the low temperature zone B. The fourth temperature probe 156 is located at the level of the communication port 130 in the lower enclosure 118 for detecting the temperature in the lower enclosure 118, and correspondingly, the fourth temperature probe 156 can detect the temperature in the deep low temperature region a and the low temperature region B. Of course, temperature probes may be provided at other locations, such as within the upper deck 116, the first containment cap 160, and the second containment cap 170, to more accurately detect temperature conditions in different areas and thereby accurately control the flow of liquid nitrogen.

The temperature detected by the third temperature probe 154 and the fourth temperature probe 156 is used as the final target temperature, and the start and stop of the whole temperature reduction process are controlled. When the temperature begins to be reduced, the electromagnetic valve 148 at the liquid inlet 147 is opened, and liquid nitrogen begins to be conveyed; when one of the third temperature probe 154 and the fourth temperature probe 156 reaches the preset temperature and the other one does not reach the preset temperature, the solenoid valve 148 is switched from the normally open state to the intermittent on-off state; when the third temperature probe 154 and the fourth temperature probe 156 both reach the preset temperature, the solenoid valve 148 is closed. The reciprocation cycles based on the temperatures sensed by the third temperature probe 154 and the fourth temperature probe 156.

The first temperature probe 150 may directly control the opening or closing of the solenoid valve 148 at a control level that is prioritized over the second temperature probe 152, the third temperature probe 154, and the fourth temperature probe 156. When the first temperature probe 150 detects that the effusion is present, the solenoid valve 148 is closed; when the evaporation of the accumulated liquid is completed, the solenoid valve 148 is opened. When the second temperature probe 152 detects that the effusion in the effusion tray 146 has risen to a preset temperature, the frequency of opening or closing the solenoid valve 148 may be reduced. Therefore, the electromagnetic valve 148 can be controlled to be opened or closed in a frequency mode, the flow of liquid nitrogen is finally controlled, the temperature of a plurality of areas is maintained, and the effect of temperature division is guaranteed.

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The utility model provides a realize temperature subregion's cooling heat preservation device which characterized in that includes:

the insulation box body comprises a first cabin body and a second cabin body which are mutually communicated through a communication port;

the first cabin body is provided with a partition structure higher than the communication port, the partition structure partitions the first cabin body into an upper cabin body and a lower cabin body along the height direction, and the partition structure is provided with a mechanism moving port communicating the upper cabin body and the lower cabin body;

and a cooling module arranged along the height direction is arranged in the second cabin body.

2. The cooling and warming device according to claim 1, wherein the mechanism moving port is provided with a sealing member capable of sealing when the mechanism moves.

3. The cooling and heat preserving device of claim 1, wherein the box wall of the heat preserving box body comprises a shell, a heat preserving layer connected with the shell and a supporting framework embedded in the heat preserving layer.

4. The cooling and heat preserving device as claimed in claim 1, wherein a first sealing cover is provided at the top of the first cabin body in the height direction, and the first sealing cover is communicated with the upper cabin body.

5. The cooling and heat preserving device as claimed in claim 1, wherein a second sealing cover is provided at the top of the second cabin body in the height direction, and the second sealing cover is communicated with the second cabin body.

6. The cooling and heat preserving device as claimed in claim 5, wherein the second sealing cover is provided with an air outlet at the top in the height direction, and the air outlet is provided with a heating module located in the second sealing cover.

7. The cooling and heat preserving device of claim 1, wherein the cooling module comprises a frame, a plurality of mesh plates mounted on the frame, a porous plate sandwiched between two mesh plates, and a shower pipe mounted on the frame.

8. The cooling and heat preserving device as claimed in claim 7, wherein a liquid accumulating plate is arranged at the bottom of the mesh plate along the height direction, and the projection profile of the liquid accumulating plate at the bottom of the second chamber body is larger than the projection profile formed by the plurality of mesh plates.

9. The cooling and heat preserving device according to claim 7, further comprising a control board, an electromagnetic valve electrically connected with the control board, and a temperature probe electrically connected with the control board, wherein the electromagnetic valve is arranged on the liquid inlet of the spraying pipe extending out of the second cabin body, and the temperature probe is arranged in the heat preserving box.

10. The cooling and warming device according to claim 1, wherein the cooling module extends from the bottom of the second cabin to a position higher than the communication port.