Artificial lung branch connection structure with fool-proof function
Technical Field
The invention relates to the technical field of medical equipment, in particular to an artificial lung branch connecting structure with a fool-proof function.
Background
The inhalation preparation has wide application prospect as an administration mode which can be used for lung targeting and systemic administration. At present, relevant inhalation therapeutic drugs are available for treatment of diseases including asthma, COPD (chronic obstructive pulmonary disease), diabetes and the like at home and abroad, but the imitation stage is still in home. In the process of imitating an inhalation preparation and developing a new drug, the inhalation preparation needs to be evaluated, and an in-vitro evaluation test device guided by the United states FDA and Chinese pharmacopoeia is an NGI (cascade impactor) at present. The structure for in vitro evaluation test by using the cascade impactor comprises: the device comprises an L-shaped connecting pipe, a preseparator, an impactor main body, a clamping component and an air flow outlet, wherein the air flow outlet is connected with a vacuum pump. The agent was introduced into the inlet through the dispersion device and deposited at various locations of the device, and the aerodynamic diameter distribution of the agent was calculated by measuring the deposition amount at each location. The L-shaped connecting pipe is an FDA right-angle throat in the United states, the oral cavity and the throat of a human body are idealized into two circular pipes which are connected at right angles, the structural difference between the two circular pipes and the real human body is quite large, so that ideal oral and throat models are developed at present, but even if the L-shaped connecting pipe is an ideal oral and throat model, only the oral and throat structures of a respiratory system are included, the difference between other respiratory structures such as a main air pipe and a bronchus and the real oral and throat structures of the real human body is not considered, and because the respiratory structures such as different ages, sexes, ethnicities and medical histories are quite large, the ideal oral and throat models cannot represent different crowds; in addition, the same person has different oral cavity volume, tongue position, glottis size and the like under different respiratory states, so that an ideal orolaryngeal model cannot cover the respiratory tract under all different respiratory states. Moreover, the test results of the structure using the conventional in vitro evaluation test using the cascade impactor are merely aerodynamic characteristics of fine particles, and then the preparation lung-entering amount is calculated according to the aerodynamic diameter of less than 5 μm as lung-entering diameter which is generally accepted in the industry. However, in the actual drug particle deposition, particles smaller than 5 μm are likely to be deposited at the oro-laryngeal position and not enter the deep lung, and the structure of in-vitro evaluation test by using a cascade impactor cannot test the deposition amount of the particles at the specific position of the respiratory tract, so that the method has no guiding significance for the evaluation of the inhalation preparation which needs to define the deposition position of the drug preparation.
In view of this, in order to solve the above problems, it is highly desirable to develop a model that can simulate the structure of the respiratory tract of a real human body and can improve the in-vitro and in-vivo correlation, so as to improve the correlation of the in-vitro test results and reduce the cost of inhaled preparation simulated pharmacy and new drug development. The technicians of the company want to develop an artificial lung model according to the real human respiratory tract structure, wherein the artificial lung model comprises all the characteristics of the human respiratory tract structure and comprises the following components: the structures of the oral cavity, the oropharynx, the epiglottis, the larynx, the main bronchus, the bronchus and the like can be used for replacing ideal oropharynx as an inhalation preparation evaluation device; the artificial lung model is reconstructed based on CT data of human respiratory tract, and can realize the tests of respiratory tracts of different people such as age, sex, race, medical history and the like; meanwhile, parameters of the artificial lung model can be adjusted according to different crowds and different respiratory states, and evaluation of inhalation preparations of different respiratory structures can be realized; finally, the technical staff of the company designs the artificial lung model in a detachable and quick-connection mode, so that the accurate measurement of the deposition amount of preparations at different fine parts of the respiratory tract can be realized, and of course, if only a part of the artificial lung is assembled, the quick measurement of a part of the whole part of the assembled artificial lung can be realized, and different test requirements can be met; the artificial lung provided by the technical staff of the company can truly and directly reflect the deposition amount of the inhalation preparation at each position of the respiratory tract, so that the correlation of in-vivo and in-vitro tests is improved. The artificial lung model developed by the technical staff of the company is adopted to carry out medicament imitation evaluation before clinical test and in the development stage, so that development time and cost can be greatly saved, the passing rate of clinical experiments can be improved, and great convenience is provided for enterprises or scientific research.
Specifically, the artificial lung model developed by the technician of the company comprises the following characteristics: oral cavity, oropharynx, epiglottis, larynx, trachea, cricoid cartilage, left main bronchus, tip posterior segment bronchus, anterior segment bronchus, left superior lobe bronchus, superior lingual segment bronchus, inferior lingual segment bronchus, left inferior lobe bronchus, anterior basal segment bronchus, lateral segment bronchus, posterior basal segment bronchus, right main bronchus, right superior lobe bronchus, tip segment bronchus, posterior segment bronchus, right medial lobe bronchus, right inferior lobe bronchus, lateral segment bronchus, medial segment bronchus, lateral basal segment bronchus and medial (cardiac) basal segment bronchus. Sometimes, for different test requirements, the artificial lung model may also include only some of the features thereof, for example, only: oral cavity, oropharynx, epiglottis and model of the mouth and throat. In the artificial lung model, the segmentation is needed from the oropharynx to the bronchus at the rear end, the segmentation principle is that at least one branch needs to be performed as long as a first-stage bronchus is generated, and in the artificial lung model, the total number of the bronchus is 20, so that the number of the segments is at least 20, the number of the segments can exceed 20, and the more deposition positions can be quantitatively measured, the more accurate the test result is; by adopting the method of the segmented model, not only can the deposition amount of each segment be tested, but also the quick-connection segments can be combined for testing.
However, due to the fact that the segmented structure is quite large, the problems that assembly is easy to make mistakes and is troublesome and the air tightness of the whole artificial lung is poor exist, the testing efficiency is reduced, and more importantly, the testing result is inaccurate, so that the method is deviated from the original purpose of designing the artificial lung model.
Disclosure of Invention
In view of this, in order to solve the above problems, the artificial lung is prone to error and troublesome in assembly. The invention provides an artificial lung branch structure with foolproof function, which comprises a quick joint male connector and a quick joint female connector, wherein a first limit guide groove and a second limit guide groove are arranged on the quick joint male connector, a first limit boss and a second limit boss are arranged on the quick joint female connector, the first limit boss and the first limit guide groove can be matched, the second limit boss and the second limit guide groove can be matched, and the opening radians of the first limit guide groove and the second limit guide groove are different, so that the first limit boss and the second limit boss can be prevented from being misplaced, and component codes are arranged on the quick joint male connector and the quick joint female connector of each artificial lung branch structure, so that the quick joint male connector and the quick joint female connector of different branch structures can be prevented from being assembled. In addition, the quick-connection male connector is further provided with a locking guide groove, the locking guide groove is provided with a certain inclination angle, a sealing ring is arranged below a first limiting boss and a second limiting boss of the quick-connection female connector, and the sealing ring is compressed through rotating the first limiting boss and the second limiting boss in the process of assembling the quick-connection male connector and the quick-connection female connector, so that a good sealing effect is achieved.
An artificial lung branch connection structure with fool-proof function, comprising: the male head 1 of quick-connect, the female head 2 of quick-connect, sealing washer or sealing washer 3, wherein the one end of the male head 1 of quick-connect is connected at the end of one of them section in the segmentation of artificial lung, and the one end of the female head 2 of quick-connect is connected at the end of other one of the segmentation of artificial lung, and can match each other between the male head 1 of quick-connect and the female head 2 of quick-connect for the end of one of them section in the segmentation of artificial lung can be with the end-to-end connection of other one of the segmentation of artificial lung, its characterized in that: the quick-connection male head main body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 penetrates through the inside of the quick-connection male head main body 15, a first limit guide groove 11, a first locking guide groove 12, a second limit guide groove 13 and a second locking guide groove 14 are arranged on the quick-connection male head main body 15, the first limit guide groove 11 and the second limit guide groove 13 are positioned at the outer side of the quick-connection male head main body 15 and close to the free end face 16, the first limit guide groove 11 is connected with the first locking guide groove 12 at the position far away from the free end face 16, the second limit guide groove 13 is connected with the second locking guide groove 14 at the position far away from the free end face 16, the included angle between the first locking guide groove 12 and the free end face 16 is theta 1, and the included angle between the second locking guide groove 14 and the free end face 16 is theta 2; the quick-connect female head main body 23 of the quick-connect female head 2 is a cylinder with a hollow upper part, the quick-connect female head main body 23 comprises a side wall 232 and a bottom plate, the center of the bottom plate is provided with a gas channel 4, the inside of the side wall 232 of the quick-connect female head main body 23 is provided with a first limit boss 21 and a second limit boss 22, the width of the first limit boss 21 is equal to that of the first limit guide groove 11, the width of the second limit boss 22 is equal to that of the second limit guide groove 13, the first limit boss 21 can be inserted into the first limit guide groove 11 and rotate along the first locking guide groove 12, and the second limit boss 22 can be inserted into the second limit guide groove 13 and rotate along the second locking guide groove 14; the sealing ring or gasket 3 is located below the free end surface 16 of the assembled quick-connect male connector 1 on the upper surface 231 of the bottom plate of the quick-connect female connector 2, the first limiting boss 21 rotates in the first locking guide groove 12, and the second limiting boss 22 compresses the sealing ring or gasket 3 when rotating in the second locking guide groove 14.
Further, the sealing ring or gasket 3 may be fixed to the upper surface 231 of the bottom plate of the quick-connect female connector 2, or may be fixed to the free end surface 16 of the quick-connect male connector 1.
Further, the sealing ring or gasket 3 may be fixed to the upper surface 231 of the bottom plate of the quick-connect female connector 2 or the free end surface 16 of the quick-connect male connector 1 by gluing.
Further, the free end surface of the quick-connect male connector 1 is a plane, and a sealing ring or a sealing gasket 3 is placed on the upper surface of the bottom plate of the quick-connect female connector 2.
Further, the bottom plate upper surface 231 of the quick-connect female connector 2 is a plane or a concave surface, and when the bottom plate upper surface 231 of the quick-connect female connector 2 is a plane, the sealing ring or the sealing gasket 3 is directly placed on the plane of the bottom plate upper surface 231; when the bottom plate upper surface 231 of the quick-connect female connector 2 is a concave surface, the concave surface forms a seal ring limiting groove 32, and the seal ring or the seal gasket 3 is placed in the seal ring limiting groove 32.
Further, a seal ring limit groove 32 is formed in the free end face of the quick-connection male connector 1, and a seal ring or a seal gasket 3 is placed in the seal ring limit groove 32 of the quick-connection male connector 1.
Further, the sealing ring or gasket 3 may be a standard round or square sealing ring or gasket, or may be a customized sealing ring or gasket with an inner special-shaped opening, where the shape of the special-shaped opening is consistent with the shape of the inner gas channel 4 of the male connector main body 15 and the inner gas channel 4 contacted by the upper surface 231 of the bottom plate of the female connector 2, and a better sealing effect may be achieved by using the customized sealing ring or gasket with the inner special-shaped opening.
Further, the included angle θ1 between the first locking guide groove 12 and the free end surface 16=the included angle θ2 between the second locking guide groove 14 and the free end surface 16, and θ1 and θ2 are acute angles, so that a better sealing effect can be achieved.
Further, one or more seal ring fixing slots 2321 are provided on the side wall 232 of the quick-connect female body 23 near the bottom plate upper surface 231. When the sealing gasket 3 is used, one or more sealing ring limiting bosses 31 are arranged on the outer side of the sealing gasket 3, and the sealing ring limiting bosses 31 can be just matched with the sealing ring fixing clamping grooves 2321, so that the sealing gasket 3 can be better fixed on the upper surface 231 of the bottom plate of the quick-connection female connector 2.
Further, each segment of the artificial lung is marked with a code, so that assembly errors of components of the artificial lung can be prevented, and assembly efficiency is improved.
Therefore, by adopting the artificial lung branch connecting structure with the fool-proof function, the connecting direction of the segmented components can be prevented from being wrong, and the influence of the connecting gap between the segmented components on the test result can be eliminated.
Drawings
FIG. 1 is a schematic diagram of an artificial lung branch connection structure with foolproof effect according to embodiment 1.
FIG. 2 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 2.
FIG. 3 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 3.
FIG. 4 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 3.
FIG. 5 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 3.
Fig. 6 is a schematic structural view of the quick-connect male connector.
The drawings will be described in detail with reference to specific embodiments.
Detailed Description
Specific embodiment case 1:
As shown in fig. 1, a schematic diagram of an artificial lung branch connection structure with fool-proofing effect according to embodiment 1 includes: the quick-connection male head 1, the quick-connection female head 2 and the sealing gasket 3, wherein one end of the quick-connection male head 1 is connected to the tail end of one section of the sections of the artificial lung, one end of the quick-connection female head 2 is connected to the tail end of the other section of the sections of the artificial lung, the quick-connection male head body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 passes through the interior of the quick-connection male head body 15, a first limit guide groove 11, a first locking guide groove 12, a second limit guide groove 13 and a second locking guide groove 14 are arranged on the quick-connection male head body 15, the first limit guide groove 11 and the second limit guide groove 13 are positioned at the positions, close to the free end surface 16, of the outer side of the quick-connection male head body 15, the first limit guide groove 11 is far away from the free end surface 16, the first locking guide groove 12 is connected to the second limit guide groove 14, the included angle between the first locking guide groove 12 and the free end surface 16 is theta 1, the included angle between the second locking guide groove 14 and the free end surface 16 is theta 2, the included angle between the first locking guide groove 14 and the free end surface 16 is the acute angle between the first locking guide groove and the free end surface 1 and the free end surface 16 is 2 theta, and the free end surface 1 = 2 and the free end surface 16; the quick-connect female connector body 23 of the quick-connect female connector 2 is a cylinder with a hollow upper part, the quick-connect female connector body 23 comprises a side wall 232 and a bottom plate, the center of the bottom plate is provided with a gas channel 4, the upper surface 231 of the bottom plate of the quick-connect female connector 2 is a plane, and the side wall 232 of the quick-connect female connector body 23 is provided with four sealing ring fixing clamping grooves 2321 close to the upper surface 231 of the bottom plate; four seal ring limiting bosses 31 are arranged on the outer side of the seal ring 3, the seal ring 3 is directly placed on the plane of the upper surface 231 of the bottom plate, and the seal ring limiting bosses 31 can be just matched with the seal ring fixing clamping grooves 2321; the inside of the side wall 232 of the quick-connection female head 23 is provided with a first limit boss 21 and a second limit boss 22, the width of the first limit boss 21 is equal to that of the first limit guide groove 11, the width of the second limit boss 22 is equal to that of the second limit guide groove 13, the first limit boss 21 can be inserted into the first limit guide groove 11 and rotate along the first locking guide groove 12, and the second limit boss 22 can be inserted into the second limit guide groove 13 and rotate along the second locking guide groove 14; the sealing gasket 3 is located below the free end surface 16 of the assembled quick-connect male connector 1 and on the upper surface 231 of the bottom plate of the quick-connect female connector 2, the first limiting boss 21 rotates in the first locking guide groove 12, and the second limiting boss 22 compresses the sealing gasket 3 when rotating in the second locking guide groove 14.
The sealing gasket 3 is a sealing ring or a sealing gasket with a customized inner special-shaped opening, the shape of the special-shaped opening is consistent with the shape of the inner gas channel 4 of the quick-connection male connector main body 15 and the shape of the inner gas channel 4 contacted with the upper surface 231 of the bottom plate of the quick-connection female connector 2, and better sealing effect can be achieved by adopting the sealing ring or the sealing gasket with the customized inner special-shaped opening. And each section of the artificial lung is marked with a code, so that assembly errors of components of the artificial lung can be prevented, and the assembly efficiency is improved.
Specific embodiment case 2:
FIG. 2 is a schematic diagram showing an artificial lung branch connection structure with fool-proofing effect according to embodiment 2; it comprises the following steps: the male head 1 of quick-connect, the female head 2 of quick-connect, sealing washer 3, wherein the one end that connects the male head 1 of quick-connect is connected at the terminal of one of them section in the segmentation of artificial lung, and the terminal of other one section in the segmentation of artificial lung is connected to the one end of female head 2 of quick-connect, its characterized in that: the quick-connection male head main body 15 of the quick-connection male head 1 is cylindrical, a gas channel 4 penetrates through the inside of the quick-connection male head main body 15, a first limit guide groove 11, a first locking guide groove 12, a second limit guide groove 13 and a second locking guide groove 14 are arranged on the quick-connection male head main body 15, the first limit guide groove 11 and the second limit guide groove 13 are positioned at the outer side of the quick-connection male head main body 15 and close to the free end face 16, the first limit guide groove 11 is connected with the first locking guide groove 12 at the position far away from the free end face 16, the second limit guide groove 13 is connected with the second locking guide groove 14 at the position far away from the free end face 16, the included angle between the first locking guide groove 12 and the free end face 16 is theta 1, and the included angle between the second locking guide groove 14 and the free end face 16 is theta 2; the included angle θ1 between the first locking guide groove 12 and the free end surface 16=the included angle θ2 between the second locking guide groove 14 and the free end surface 16, and θ1 and θ2 are acute angles; the quick-connection female head main body 23 of the quick-connection female head 2 is a cylinder with a hollowed upper part, the quick-connection female head main body 23 comprises a side wall 232 and a bottom plate, the center of the bottom plate is provided with a gas channel 4, the free end surface of the quick-connection male head 1 is a plane, when the upper surface 231 of the bottom plate of the quick-connection female head 2 is a concave surface, a seal ring limiting groove 32 is formed on the concave surface, a seal ring 3 is placed in the seal ring limiting groove 32, and a standard round seal ring is used for the seal ring 3; the inside of the side wall 232 of the quick-connection female head 23 is provided with a first limit boss 21 and a second limit boss 22, the width of the first limit boss 21 is equal to that of the first limit guide groove 11, the width of the second limit boss 22 is equal to that of the second limit guide groove 13, the first limit boss 21 can be inserted into the first limit guide groove 11 and rotate along the first locking guide groove 12, and the second limit boss 22 can be inserted into the second limit guide groove 13 and rotate along the second locking guide groove 14; the sealing ring 3 is located below the free end surface 16 of the assembled quick-connect male connector 1 and on the upper surface 231 of the bottom plate of the quick-connect female connector 2, the first limiting boss 21 rotates in the first locking guide groove 12, and the second limiting boss 22 compresses the sealing ring 3 when rotating in the second locking guide groove 14.
Each segment of the artificial lung is marked with a code, so that assembly errors of components of the artificial lung can be prevented, and assembly efficiency is improved.
Specific embodiment 3:
FIG. 3 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 3. The only difference between the artificial lung branch connection structure with fool-proof effect in this technical solution and the specific embodiment 2 is that the seal ring limiting groove 32 is disposed on the free end face of the quick-connect male connector 1, and the upper surface 231 of the bottom plate of the quick-connect female connector 2 is a plane, so that the solution will not be described again.
Specific embodiment 4:
FIG. 4 is a schematic diagram showing an artificial pulmonary branch connecting structure with foolproof effect according to embodiment 4. The only difference between the artificial lung branch connection structure with fool-proof effect in this technical solution and the specific embodiment 2 is that the sealing ring 3 is a customized sealing ring with an inner special-shaped opening, and the shape of the special-shaped opening is consistent with the shape of the inner gas channel 4 of the quick-connect male connector main body 15 and the shape of the inner gas channel 4 contacted with the upper surface 231 of the bottom plate of the quick-connect female connector 2. Therefore, the scheme is not repeated.
Specific embodiment case 5:
Fig. 5 is a schematic diagram showing an artificial lung branch connection structure with foolproof effect according to embodiment 5. The only difference between the artificial lung branch connection structure with fool-proof effect in this technical solution and the specific embodiment 3 is that the sealing ring 3 is a customized sealing ring with an inner special-shaped opening, and the shape of the special-shaped opening is consistent with the shape of the inner gas channel 4 of the quick-connect male connector main body 15 and the shape of the inner gas channel 4 contacted with the upper surface 231 of the bottom plate of the quick-connect female connector 2. Therefore, the scheme is not repeated.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.