CN110604555A - System for evaluating hypertension risk - Google Patents

System for evaluating hypertension risk Download PDF

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CN110604555A
CN110604555A CN201810634877.4A CN201810634877A CN110604555A CN 110604555 A CN110604555 A CN 110604555A CN 201810634877 A CN201810634877 A CN 201810634877A CN 110604555 A CN110604555 A CN 110604555A
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blood pressure
module
risk
measuring unit
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蒋峰
蒋彤
方亮
岳宏
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BEIJING DONGFANG XINGQI FOOD PRODUCT INDUSTRY TECHN Co Ltd
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BEIJING DONGFANG XINGQI FOOD PRODUCT INDUSTRY TECHN Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/02108Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/321Arterial hypertension

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Abstract

The present invention relates to the field of risk assessment of hypertensive disorders, in particular to a system for assessing risk of hypertension. The system comprises: a limb blood pressure measuring unit (1), a kidney bioactivity measuring unit (2), an interstitial hormone level measuring unit (3) and a body metabolite vitamin level measuring unit (4). By measuring the blood pressure of four limbs, combining the biological activity of the kidney, the hormone in the stroma and the vitamin in the metabolite of the organism, preferably combining the indexes such as PWV, ABI and the like, evaluating the arterial elasticity and the vascular occlusion degree of the lower limbs of a human body, preferably combining the biological activity of the left ventricle, the biological activity of the adrenal medulla, the catecholamine in the stroma, the trace element in the metabolite of the organism and the like, comprehensively evaluating the change conditions of the indexes, and analyzing multiple factors and multiple angles, scientific data support is provided for predicting the capability of regulating the blood pressure of the human body, and the fluctuation of the blood pressure is prevented from being predicted by detecting the apparent blood pressure value only clinically.

Description

System for evaluating hypertension risk
Technical Field
The present invention relates to the field of risk assessment of hypertensive disorders, in particular to a system for assessing risk of hypertension.
Background
Factors influencing the onset of hypertension are many, and important risk factors such as high-sodium and low-potassium diet; overweight and obesity; drinking; mental stress, etc. At present, a sphygmomanometer is clinically used for measuring the blood pressure of four limbs of a human body, the measured blood pressure value is only an apparent numerical value, is easily influenced by the emotion, diet and exercise of the human body in a short period, and cannot objectively reflect the regulation and control capability of the human body on the blood pressure of the human body, so that the risk assessment of the hypertension is inaccurate.
The awareness rate, treatment rate and control rate of the hypertension population in China are far from the control rate of the hypertension population in developed countries. In order to improve the awareness rate, treatment rate and control rate of hypertension, the prior art provides the following ways: the blood pressure of community people is investigated in a questionnaire investigation mode, the investigation data is subjected to primary prevention sampling screening, and the screened data is analyzed to obtain the hypertension probability of the people, so that the knowing rate, the treatment rate and the control rate of the hypertension are improved. However, the manual cost for surveying the blood pressure of community people by adopting the questionnaire survey mode is high, and the collected data is not objective.
Disclosure of Invention
The invention aims to overcome the problems in the prior art, and provides a system for evaluating the risk of hypertension, which can evaluate the capability of regulating hypertension of a human body by taking various indexes into consideration and can provide a reference basis for early evaluation of the risk of hypertension.
To achieve the above object, an aspect of the present invention provides a system for assessing risk of hypertension, the system comprising: a limb blood pressure measuring unit, a kidney biological activity measuring unit, an interstitial hormone level measuring unit and a body metabolite vitamin level measuring unit.
Preferably, the interstitial hormone level measuring unit comprises: a module for measuring the level of adrenal medullary hormone in the interstitium and/or a module for measuring the level of diuretic hormone in the interstitium.
Preferably, the system further comprises: a pulse wave waveform determination unit to obtain a pulse wave velocity PWV and an ankle brachial index ABI.
Preferably, the system further comprises: catecholamine level in stroma.
Preferably, the system further comprises: aldosterone level determination unit in the interstitium.
Preferably, the system further comprises: a biological activity measuring unit of the left ventricle and/or a biological activity measuring unit of the adrenal medulla.
Preferably, the vitamin level determination unit in the body metabolites includes at least one of a vitamin C level determination module, a vitamin E level determination module and a vitamin F level determination module.
Preferably, the system further comprises a unit for measuring the level of trace elements in the metabolic products of the body.
Preferably, the measuring unit for the level of the trace elements in the metabolic products of the organism comprises at least one of a sodium element level measuring module, a germanium element level measuring module, a calcium element level measuring module, a magnesium element level measuring module, a silicon element level measuring module, a selenium element level measuring module, a potassium element level measuring module, a molybdenum element level measuring module and a chromium element level measuring module.
By measuring the blood pressure of limbs, combining the bioactivity of the kidney, the hormone in the stroma (preferably comprising the adrenal medulla hormone of the stroma, the aldosterone of the stroma and the antidiuretic hormone of the stroma) and the vitamin in the metabolite of the organism (preferably comprising the vitamin C, the vitamin E and the vitamin F), and preferably combining the indexes of PWV, ABI and the like, the arterial elasticity and the vascular occlusion degree of the lower limbs of the human body are evaluated, and preferably combining the comprehensive evaluation of the indexes of the bioactivity of the left ventricle, the bioactivity of the adrenal medulla, the catecholamine of the stroma, the trace elements in the metabolite of the organism (preferably comprising the sodium element, the germanium element, the calcium element, the magnesium element, the silicon element, the selenium element, the potassium element, the molybdenum element and the chromium element) and the like, the analysis of multiple factors and multiple angles provides scientific data support for the prediction of the capability of regulating the blood pressure of the human body, the fluctuation of the blood pressure predicted by detecting the apparent blood pressure value in a single clinical way is avoided.
Drawings
Fig. 1 is a system for evaluating risk of hypertension according to the present invention.
Description of the reference numerals
1 Limb blood pressure measuring unit
2 kidney biological activity measuring unit
3 hormone level measuring unit in mesenchyme
4 vitamin level measuring unit in organism metabolite
5 pulse wave waveform measuring unit
Catecholamine level determination unit in 6 interstitial substances
7 interstitial aldosterone level determination unit
8 left ventricular bioactivity determination unit
9 biological activity measuring unit of adrenal medulla
10 measuring unit for trace element level in organism metabolite
Detailed Description
The following detailed description of embodiments of the invention refers to the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation.
As shown in fig. 1, the present invention provides a system for assessing risk of hypertension, characterized in that the system comprises: a limb blood pressure measuring unit 1, a kidney bioactivity measuring unit 2, an interstitial hormone level measuring unit 3 and a body metabolite vitamin level measuring unit 4.
Limb blood pressure measuring unit 1
The invention can measure the blood pressure of four limbs synchronously for many times, and can judge the state of the blood pressure of four limbs more intuitively, thereby judging the blood pressure condition of a subject, wherein the normal range of the blood pressure is as follows: the systolic pressure is less than 120; diastolic pressure < 80.
Kidney biological activity measuring Unit 2
It is specified in the present invention that the normal range of biological activity of the kidney by bioelectrical detection (e.g. a french eagle exercise e.i.s. human function scanner) is-20 to +20, when 20 < biological activity of the kidney < 60, or-60 < biological activity of the kidney < -20, then this means a risk of possible concomitant mild elevation of blood pressure; the biological activity of the kidney is more than or equal to 60 and less than 100, or the biological activity of the kidney is more than or equal to 100 and less than or equal to 60, and the risk of obviously increasing the blood pressure is possibly accompanied.
Interstitial hormone level measuring unit 3
Like heart and liver, stroma is an organ of the human body and is grouped by a group of tissues with specific structures to jointly complete a specific task. The inventors of the present invention have found that the condition of body blood pressure can be effectively reflected by measuring the levels of some hormones in the interstitium.
Preferably, the hormone may be adrenal medullary hormone in the interstitium, antidiuretic hormone, etc. Thus, the interstitial hormone level measuring unit 3 preferably includes an interstitial adrenal medullary hormone level measuring module and/or an interstitial antidiuretic hormone level measuring module.
Measuring module for adrenal medulla hormone level in mesenchyme
In the present invention, it is specified that the normal range of adrenal medullary hormone levels in the interstitium as measured by bioelectricity (e.g., eagle performance e.i.s. scanner for human function, france) is-20 to +20, where interstitial adrenal medullary hormone > 20 may be associated with a risk of blood pressure increase, the higher the number, the higher the risk of blood pressure increase; interstitial adrenomedullin < -20, possibly associated with a risk of blood pressure reduction, the smaller the number the higher the risk of blood pressure reduction.
Measuring module for anti-diuretic hormone level in mesenchyme
In the present invention, it is specified that the normal range of interstitial antidiuretic hormone levels by bioelectrical detection (e.g., eagle performance e.i.s. body function scanner in france) is-20 to +20, where interstitial antidiuretic hormone > 20 may be associated with a risk of blood pressure rise, the higher the number, the higher the risk of blood pressure rise; interstitial antidiuretic hormone < -20, which may be associated with a risk of blood pressure reduction, the smaller the number, the higher the risk of blood pressure reduction.
Catecholamine level in interstitium measuring unit 6
In order to further improve the accuracy of the assessment of the risk of hypertension according to the present invention, the system of the present invention further preferably comprises an interstitial catecholamine level determination unit 6.
In the present invention, it is specified that the normal range of catecholamine levels in the interstitium by bioelectrical detection (e.g. eagle performance e.i.s. human function scanner in france) is-20 to +20, with a risk of blood pressure increase that may accompany more catecholamine in the interstitium > 20, the higher the number, the higher the risk of blood pressure increase; catecholamines < -20 in the interstitium may be associated with a risk of blood pressure reduction, the smaller the number, the higher the risk of blood pressure reduction.
Interstitial aldosterone level determination unit 7
In order to further improve the accuracy of the evaluation of the risk of hypertension according to the present invention, the system of the present invention further preferably comprises an interstitial aldosterone level determining unit 7.
In the present invention, it is specified that the normal range of aldosterone levels in the stroma as measured by bioelectricity (e.g., eagle performance e.i.s. human function scanner in france) is-20 to +20, with a risk of elevated blood pressure being likely to accompany greater aldosterone in the stroma, with greater numbers higher risk of elevated blood pressure; aldosterone < -20 in the interstitium may be associated with a risk of blood pressure reduction, the smaller the number the higher the risk of blood pressure reduction.
Biological Activity measurement Unit 8 of the left ventricle
In order to further increase the accuracy of the assessment of the risk of hypertension according to the present invention, the system of the present invention further preferably comprises a biological activity determination unit 8 of the left ventricle.
It is specified in the present invention that the normal range of biological activity of the left ventricle by bioelectrical examination (e.g. french eagle exercise e.i.s. human functional scanner) is-20 to +20, possibly accompanied by a risk of mild elevation of blood pressure if 20 < biological activity of the left ventricle < 60, or-60 < biological activity of the left ventricle < -20; if the biological activity of the left ventricle is more than or equal to 60 and less than 100, or the biological activity of the left ventricle is more than or equal to-100 and less than or equal to-60, the risk of obvious increase of blood pressure is possibly accompanied.
Adrenal medulla bioactivity determination unit 9
In order to further improve the accuracy of the assessment of the risk of hypertension according to the present invention, the system of the present invention further preferably comprises a biological activity measuring unit 9 of adrenal medulla.
In the present invention, it is specified that the normal range of the biological activity of the adrenal medulla by bioelectrical detection (e.g. french eagle exercise e.i.s. human function scanner) is-20 to +20, possibly accompanied by a risk of a slight increase in blood pressure if 20 < the biological activity of the adrenal medulla < 60; 60 < adrenal medulla has a biological activity < 100, which may be accompanied by a risk of a significant increase in blood pressure.
The French eagle performance E.I.S. human body function scanner used in the invention adopts a low-voltage direct current stimulation induction technology, continuously sends self-adaptive and automatically-adjusted low-voltage (1.28V) direct current signals which are on average 255 times per 3 seconds to an individual region of a human body 22 through 6 electrodes symmetrically arranged on the forehead, hands and feet, the electric signals are converted into ion streams in human body tissues, and resistance, electric conductivity, PH value and voltage penetrating through the tissues and action potentials penetrating through cell membranes are obtained according to polarization motions of the ion streams at the cathode and anode electrodes, so that the electrophysiological activities of interstitial cells of various human organs are activated. And according to the one-way conductivity of the physiological feedback signal, performing real-time current analysis, acquiring human body function information in a digital form, and performing 3D reconstruction on data through a digital model. The comprehensive function evaluation of each tissue and each organ of the whole body can be carried out within a few minutes.
Vitamin level determination unit 4 in body metabolites
Preferably, the vitamin may be at least one of vitamin C, vitamin E and vitamin F. Therefore, the vitamin level determination unit 4 in the body metabolites preferably includes at least one of a vitamin C level determination module, a vitamin E level determination module, and a vitamin F level determination module.
Vitamin C level measuring module
In the present invention, it is specified that the normal range of vitamin C level measured by a biological weak magnetic field detection technique (for example, Elder AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Vc mainly has the effects of protecting, regulating and promoting catalysis of an enzyme system, preventing peroxidation and protecting heart and cerebral vessels. It was found that if the level of Vc exceeds the normal range, this means that the risk of fluctuations in blood pressure is increasing, the greater the magnitude of the index fluctuations, the higher the risk of blood pressure fluctuations. Specifically, Vc < 40 means that the human body is lack of Vc for a long time, and Vc > 100 means that the human body takes too much Vc in a short time or the utilization rate of Vc in the human body is not high. Both too high and too low values are detrimental to blood pressure regulation.
Vitamin E level measuring module
In the present invention, it is specified that the normal range of vitamin E level measured by a biological weak magnetic field detection technique (for example, Elder AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. VE has auxiliary effect on cardiovascular, strong antioxidation, and can inhibit fatty acid oxidation, reduce lipofuscus formation, and protect cells from free radical damage. It was found that if the level of VE exceeds the normal range, meaning that the risk of fluctuations in blood pressure is increasing, the greater the magnitude of the index fluctuation, the higher the risk of blood pressure fluctuations. Specifically, VE < 40 means that the human body is lack of VE for a long time, VE > 100 means that the human body is over-ingested or the use ratio of VE in the body is low in a short time. Both too high and too low values are detrimental to blood pressure regulation.
Vitamin F level determination module
In the present invention, it is specified that the normal range of vitamin F level measured by a biological weak magnetic field detection technique (for example, Elder AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. VF is primarily helpful in preventing arteriosclerosis and maintaining normal blood pressure. It was found that if the level of VF exceeds the normal range, this means that the risk of fluctuations in blood pressure is increasing, the greater the magnitude of the index fluctuations, the higher the risk of blood pressure fluctuations. Specifically, VF < 40 means that the human body is lack of VF for a long time, and VF > 100 means that the human body is excessively ingested in a short time or the utilization rate of VF in the body is low. Both too high and too low values are detrimental to blood pressure regulation.
Measuring unit 10 for trace element level in organism metabolite
According to the invention, in order to further improve the accuracy of the risk assessment of hypertension, the system of the invention further comprises a determination unit 10 for the level of trace elements in the metabolic products of the organism.
Preferably, the trace element may be at least one of sodium, germanium, calcium, magnesium, silicon, selenium, potassium, molybdenum and chromium. Therefore, the unit 10 for measuring the level of trace elements in metabolites of the body preferably includes at least one of a sodium element level measuring module, a germanium element level measuring module, a calcium element level measuring module, a magnesium element level measuring module, a silicon element level measuring module, a selenium element level measuring module, a potassium element level measuring module, a molybdenum element level measuring module, and a chromium element level measuring module.
Sodium element level measuring module
In the present invention, it is specified that the normal range of the sodium level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Sodium is mainly involved in the physiological process of cells to maintain blood pressure balance, and the finding that if the level of sodium element exceeds the normal range, the risk of blood pressure fluctuation is gradually increased, and the larger the amplitude of index fluctuation is, the higher the risk of blood pressure fluctuation is. Specifically, sodium content < 50 indicates a long-term deficiency of sodium in humans, and sodium content > 100 indicates a short-term excessive intake of sodium by the body or a low availability of sodium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Germanium element level measuring module
In the present invention, the normal range of the germanium element level measured by a biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Germanium has been found to regulate enzyme activity and vitamin metabolism, thereby indirectly regulating blood pressure. If the level of germanium element exceeds the normal range, it means that the risk of blood pressure fluctuation is gradually increased, and the larger the amplitude of index fluctuation is, the higher the risk of blood pressure fluctuation is. Specifically, a germanium content of < 50 indicates a long-term lack of sodium in the human body, and a germanium content of > 100 indicates a short-term excessive uptake of germanium into the body or a low availability of germanium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Calcium element level measuring module
In the present invention, it is specified that the normal range of the calcium level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Calcium is mainly involved in the blood coagulation process and has an activating effect on a plurality of enzymes, and the invention discovers that the calcium element also has the effect of regulating blood pressure. If the level of calcium exceeds the normal range, this means that the risk of fluctuations in blood pressure is increasing, and the greater the magnitude of the index fluctuations, the higher the risk of fluctuations in blood pressure. Specifically, a calcium content of less than 50 indicates a long-term deficiency of calcium in the human body, and a calcium content of more than 100 indicates an excessive intake of calcium into the body in a short term or a low availability of calcium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Magnesium element level measuring module
In the present invention, the normal range of the magnesium level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Magnesium mainly regulates adrenal gland, oxygen and energy, participates in energy metabolism in vivo, inhibits excitability of nerve and muscle conduction, and helps to prevent arteriosclerosis and myocardial infarction. It was found that magnesium can also regulate blood pressure, and if the level of magnesium exceeds the normal range, it means that the risk of blood pressure fluctuation is gradually increased, and the larger the magnitude of index fluctuation, the higher the risk of blood pressure fluctuation. Specifically, a magnesium content of less than 50 indicates a long-term lack of magnesium in the human body, and a magnesium content of more than 100 indicates an excessive intake of magnesium into the body in a short term or a low availability of magnesium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Silicon element level measuring module
In the present invention, the normal range of the silicon element level measured by a biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Silicon mainly maintains vascular permeability and prevents vascular sclerosis, and it is found that if the level of silicon element exceeds the normal range, it means that the risk of blood pressure fluctuation is gradually increased, and the larger the amplitude of index fluctuation is, the higher the risk of blood pressure fluctuation is. Specifically, a silicon content of less than 50 means that the human body is short of silicon for a long time, and a silicon content of more than 100 means that the human body takes too much silicon in a short time or the silicon utilization rate in the body is not high. Both too high and too low values are detrimental to blood pressure regulation.
Selenium element level measuring module
In the present invention, the normal range of the selenium level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Selenium mainly protects the structure and function of a cell membrane, has a synergistic effect with vitamin E and participates in lipid metabolism and immune function regulation, and is found to regulate blood pressure, if the level of the selenium exceeds a normal range, the risk of fluctuation of the blood pressure is increased gradually, and the larger the amplitude of the index fluctuation is, the higher the risk of the blood pressure fluctuation is. Specifically, a selenium content of less than 50 means a long-term lack of selenium in the human body, and a selenium content of more than 100 means a short-term excessive selenium intake by the body or a low availability of selenium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Potassium element level measuring module
In the present invention, it is specified that the normal range of the potassium level measured by a biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Potassium is mainly involved in intracellular carbohydrate and protein metabolism, maintains normal excitability of nerves and muscles together with calcium and phosphorus, coordinates normal contraction and relaxation of cardiac muscle, and regulates blood pressure. It was found that if the level of potassium element exceeds the normal range, it means that the risk of fluctuation of blood pressure is gradually increasing, and the larger the magnitude of the index fluctuation, the higher the risk of blood pressure fluctuation. Specifically, a potassium content of less than 50 indicates a long-term lack of potassium in the human body, and a potassium content of more than 100 indicates an excessive intake of potassium by the body in a short term or a low availability of potassium in the body. Both too high and too low values are detrimental to blood pressure regulation.
Molybdenum element level measuring module
In the present invention, it is specified that the normal range of the molybdenum level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Molybdenum is mainly used for protecting cardiac muscle, and is found to have the effect of preventing cardiovascular diseases. If the level of molybdenum element exceeds the normal range, it means that the risk of blood pressure fluctuation is gradually increased, and the larger the magnitude of index fluctuation, the higher the risk of blood pressure fluctuation. Specifically, a molybdenum content of less than 50 indicates a long-term lack of molybdenum in the human body, and a molybdenum content of more than 100 indicates a short-term excessive molybdenum intake by the body or a low availability of molybdenum in the body. Both too high and too low values are detrimental to blood pressure regulation.
Chromium element level measuring module
In the present invention, the normal range of the chromium level measured by the biological weak magnetic field detection technique (for example, an ereider AGEREADER biological weak magnetic field measurement analyzer) is 50 to 100. Chromium mainly increases the breakdown and excretion of cholesterol, reduces blood cholesterol levels, and has been found to also alleviate arteriosclerosis. If the level of chromium exceeds the normal range, this means that the risk of fluctuations in blood pressure is increasing, the greater the magnitude of the index fluctuations, the higher the risk of fluctuations in blood pressure. Specifically, a chromium content of less than 50 indicates a long-term lack of chromium in the human body, and a chromium content of > 100 indicates a short-term excessive intake of chromium by the body or a low utilization of chromium in the body. Both too high and too low values are detrimental to blood pressure regulation.
The organism weak magnetic field determination analyzer Eleder AGEREADER used in the invention is based on quantum medicine and quantum physics as theory, and analyzes and interprets different magnetic field information contained in human tissues and organs by adopting a normal temperature magnetic field resonance interferon molecule generation system according to the principle and the characteristic of quantum physics and quantum medicine, thereby sensing the functional state of each tissue and organ of the organism.
Pulse wave waveform measuring unit 5
According to the present invention, in order to further improve the accuracy of the evaluation of the risk of hypertension, the system of the present invention further preferably includes a pulse wave waveform determination unit 5 to obtain a pulse wave velocity PWV and an ankle brachial index ABI.
Here, PWV means Pulse Wave Velocity (PWV), and is distance (L)/pulse wave transit time (PTT). During each process of the heart pumping blood to the aorta, the aorta wall generates pulse wave and propagates along the blood vessel wall to the peripheral at a certain speed, the wave is the pulse wave, and the conduction speed of the pulse wave in the artery is the pulse wave conduction speed. Arterial tone is not only a determinant of systolic, diastolic and pulse pressure levels, but also reflects considerably endothelial function status, and arterial hypo-tone has become one of the important hallmarks of cardiovascular risk.
The reference value of PWV is 1400cm/sec regardless of age factors. An increase in PWV indicates increased arterial stiffness, poor compliance and a greater risk of cardiovascular and cerebrovascular disease. Otherwise, the blood vessel hardness is low and the compliance is good. In particular, the method comprises the following steps of,
firstly, PWV is normal when the PWV is higher than a normal value by less than 20 percent;
secondly, the PWV is slightly hardened by 20 to 30 percent higher than the normal value;
③ the PWV is higher than 30-50% of the normal value and belongs to moderate hardening;
and fourthly, the severe sclerosis is caused by that PWV is higher than the normal value by more than 50 percent.
When the PWV of the artery is larger than or equal to 1700cm/sec, the risk of blood pressure fluctuation is gradually increased, the higher the numerical value is, the higher the risk of blood pressure fluctuation is, and by combining the numerical value of ABI, the higher the risk of blood pressure fluctuation is when the ABI is abnormal under the same elasticity of the artery.
The ABI means Ankle Brachial Index (ABI), which is the ratio of ankle artery (posterior tibial or instep artery) to brachial artery systolic pressure, and the ABI reduces independent risk factors of cardiovascular and cerebrovascular events and is a strong predictor of the total death rate and cardiovascular death rate of patients with cardiovascular and cerebrovascular diseases.
ABI is widely used as an index for diagnosing obstructive Arteriosclerosis (ASO), and its judgment standard was made by AHA (american heart institute) in 1993. The normal range is 0.9-1.4.
ABI < 0.9: there is a possibility of arterial blockage.
ABI < 0.8: the likelihood of arterial blockage is high.
(iii) 0.5< ABI < 0.8: one place has an arterial blockage.
ABI < 0.5: there are many places where arterial occlusions exist.
0.9< ABI < 1.0: arteries have a tendency to become occluded.
Sixthly, 1.3< ABI < 1.4: arteries tend to harden.
The pulse wave waveform can be measured by adopting an ohm Longcolin-full-automatic arteriosclerosis detector BP203RPE-II, so that PWV and ABI can be obtained. The instrument applies oscillography normal linear expansion technology, uses high-precision double-layer Cuff (Cuff), detects electrocardiogram and phonocardiogram, simultaneously measures the waveforms of blood pressure and pulse wave of four limbs, and measures ABI, PWV and other numerical values. In the process that the heart sends blood out of the aorta each time, the aortic wall generates pulse waves and the pulse waves are transmitted to the tip along the vascular wall at a certain speed, the wave motion is the pulse waves, the conduction speed of the pulse waves in the artery is the pulse wave conduction speed (PWV), the conduction speed can be obtained by measuring the pulse wave conduction time (PTT) and the distance (L) between two artery recording parts, and the calculation formula is as follows: PWV (cm/s) ═ L/PTT. Generally, the larger the value, the harder the vessel wall is reflected. Ankle brachial blood pressure index (ABI) refers to the ratio of the systolic pressure of the posterior tibial artery or dorsal plantar artery to the systolic pressure of the brachial artery. ABI is mainly used for evaluating the stenosis and obstruction conditions of arterial blood vessels of lower limbs.
Nutritional exercise advice
According to the present invention, the more the above index deviates from the normal range, indicating that the risk of developing hypertension is higher, the present invention gives the following nutrition exercise advice for the subject with higher risk of developing hypertension.
(1) Diet prevention: the intake of fat is reduced, and the consumption of saturated fatty acid is reduced, and the consumption of fried food, shrimp, liver, kidney and other viscera containing high cholesterol food, egg yolk, etc. is increased. Can be supplemented with rhizoma Zingiberis recens, milk, semen glycines, Bulbus Allii Cepae, sea fish, fructus Citri Tangerinae, fructus crataegi, folium Camelliae sinensis, fructus Solani Melongenae, herba Avenae Fatuae, Amyda sinensis, Auricularia, and sweet potato, and has effect in preventing arteriosclerosis.
(2) No smoking and avoidance of passive smoking: tobacco poisons cardiovascular endothelial cells, damages endothelial system function, can cause myocardial hypertrophy and thickening, can compromise normal relaxation movement, and can cause high-density lipoprotein reduction.
(3) Adherence to a suitable rhythmic movement: the exercise amount is determined according to the physical condition, and the exercise should be gradually conducted, so that the exercise is not reluctant to do strenuous exercise, and the exercise is preferably continued for not less than 30 minutes every day, and can be completed once or conducted in 3 times, each time for 10 minutes. According to individual conditions, the sports such as aerobic running, rope skipping, health gymnastics, Taijiquan boxing, cycling, walking, flower and grass trimming, mopping, housework drying and the like are carried out.
(4) Release of depressed or stressed emotions: chronic depression or persistent stress can stimulate sympathetic nerve excitation, which can cause rapid heartbeat, vasoconstriction, blood pressure increase and blood flow decrease, so that people need to pay attention to maintain mood stability in daily life.
(5) The health-care food supplements alfalfa, red yeast rice, lecithin, catechin and the like in a proper amount, and is beneficial to regulating blood fat and softening blood vessels, so that the capability of regulating blood pressure of a human body is improved.
Examples
Respectively selecting 10 suspected hypertension patients (clinically undiagnosed hypertension, but with hypertension symptoms such as dizziness, headache, neck tightening, fatigue, palpitation) and healthy people, measuring their limb blood pressure, measuring renal bioactivity, left ventricular bioactivity, adrenal medulla bioactivity, mesenchyma adrenal medulla hormone level, mesenchyma anti-diuretic hormone level, mesenchyma catecholamine level, and mesenchyma aldosterone level with French eagle exercise E.I.S. human body function scanner, measuring urine vitamin C level, vitamin E level, vitamin F level, sodium level, germanium level, calcium level, magnesium level, silicon level, selenium level, potassium level, molybdenum level, and chromium level with Elder AGEREADER organism weak magnetic field measuring analyzer, pulse wave waveforms were measured using an ohroncholin-full automatic arteriosclerosis detector BP203RPE-II to obtain PWV and ABI, with the results shown in table 1.
TABLE 1
As can be seen from the table above, although 50-60 suspected hypertensive groups are selected, after the detection of the system disclosed by the invention, the blood pressure of limbs is normal, more than 70% of other indexes of the suspected hypertensive groups are abnormal, which indicates that the capability of regulating the blood pressure of a human body is poor and corresponds to the subjective feeling of the human body; after 50-60 healthy people are detected by the system, all indexes are almost in a normal range. Thus illustrating that the system for assessing the risk of hypertension is more accurate and comprehensive than prior art assessments.
The invention evaluates the arterial elasticity and the lower limb vascular occlusion degree of a human body by measuring the blood pressure of four limbs, combining the bioactivity of the kidney, the hormones in the interstitium (preferably comprising interstitial adrenal medullary hormone, interstitial aldosterone and interstitial antidiuretic hormone) and the vitamins in the metabolic products of the organism (preferably comprising vitamin C, vitamin E and vitamin F) and preferably combining the indexes of PWV, ABI and the like through a comprehensive evaluation mode, and preferably combines the bioactivity of the left ventricle, the bioactivity of the adrenal medulla, the bioactivity of the interstitium, the change condition of the indexes of catecholamine and the metabolic products of the organism (preferably comprising sodium element, germanium element, calcium element, magnesium element, silicon element, selenium element, potassium element, molybdenum element and chromium element) and the like to comprehensively evaluate, therefore, the capability of regulating the hypertension of a human body is evaluated by comprehensively passing through the state of blood vessels, the hormone secretion condition for regulating the blood pressure and the change condition of vitamin and mineral contents influencing the regulation of the blood pressure, analyzing the multiple factors and the multiple angles, providing a reference basis for early evaluating the morbidity risk of the hypertension, and avoiding the fluctuation of the blood pressure predicted by clinically detecting the blood pressure singly.
The preferred embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, numerous simple modifications can be made to the technical solution of the invention, including combinations of the individual specific technical features in any suitable way. The invention is not described in detail in order to avoid unnecessary repetition. Such simple modifications and combinations should be considered within the scope of the present disclosure as well.

Claims (9)

1. A system for assessing risk of hypertension, the system comprising: a limb blood pressure measuring unit (1), a kidney bioactivity measuring unit (2), an interstitial hormone level measuring unit (3) and a body metabolite vitamin level measuring unit (4).
2. The system according to claim 1, wherein the interstitial hormone level determination unit (3) comprises: a module for measuring the level of adrenal medullary hormone in the interstitium and/or a module for measuring the level of diuretic hormone in the interstitium.
3. The system of claim 1 or 2, wherein the system further comprises: a pulse wave waveform measuring unit (5) to obtain a pulse wave velocity PWV and an ankle brachial index ABI.
4. The system of claim 1 or 2, wherein the system further comprises: and (6) a catecholamine level determination unit in the interstitium.
5. The system of claim 1 or 2, wherein the system further comprises: and (7) an aldosterone level measuring unit in mesenchyme.
6. The system of claim 1 or 2, wherein the system further comprises: a biological activity measuring unit (8) of the left ventricle and/or a biological activity measuring unit (9) of the adrenal medulla.
7. The system according to claim 1, wherein the determination unit (4) of the level of vitamins in the body metabolites comprises at least one of a vitamin C level determination module, a vitamin E level determination module and a vitamin F level determination module.
8. The system according to claim 1, wherein the system further comprises a determination unit (10) of the level of trace elements in the body metabolites.
9. The system according to claim 8, wherein the unit (10) for measuring the level of trace elements in the metabolic products of the body comprises at least one of a sodium element level measuring module, a germanium element level measuring module, a calcium element level measuring module, a magnesium element level measuring module, a silicon element level measuring module, a selenium element level measuring module, a potassium element level measuring module, a molybdenum element level measuring module, and a chromium element level measuring module.
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