CN110604303A - Rhizoma polygonati paste and preparation method thereof - Google Patents
Rhizoma polygonati paste and preparation method thereof Download PDFInfo
- Publication number
- CN110604303A CN110604303A CN201910891179.7A CN201910891179A CN110604303A CN 110604303 A CN110604303 A CN 110604303A CN 201910891179 A CN201910891179 A CN 201910891179A CN 110604303 A CN110604303 A CN 110604303A
- Authority
- CN
- China
- Prior art keywords
- rhizoma polygonati
- steaming
- paste
- water
- sealwort
- Prior art date
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- Pending
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K36/8969—Polygonatum (Solomon's seal)
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Abstract
The invention discloses a polygonatum sibiricum ointment and a preparation method thereof, wherein the polygonatum sibiricum ointment is mainly prepared from the following raw materials in percentage by weight: 40-60 parts of rhizoma polygonati, 140-160 parts of white granulated sugar, 50-70 parts of sweet potato starch, 30-50 parts of lotus root starch and 5-10 parts of edible gelatin; the rhizoma polygonati paste disclosed by the invention not only obviously enhances the health care function of the rhizoma polygonati paste on the spleen and the stomach through the reasonable compatibility of the rhizoma polygonati, the sweet potato powder and the lotus root starch, but also can effectively prevent and treat the diseases of the spleen and the stomach; the added white granulated sugar and edible gelatin are also utilized, so that the cream has better formability, light sweet taste, obviously improved sensory properties, convenient sealing, subpackaging and eating and longer quality guarantee period, thereby being beneficial to the large-scale production, popularization and application of the polygonatum cream.
Description
Technical Field
The invention relates to the field of health-care medicines, and particularly relates to polygonatum sibiricum paste and a preparation method thereof.
Background
Polygonatum sibiricum is a common traditional Chinese medicinal material, is recorded as the dried rhizome of Polygonatum kingianum, Polygonatum sibiricum or Polygonatum cyrtonema of Liliaceae in 2015 edition of Chinese pharmacopoeia (one), is called rheum officinale essence, Polygonatum capitatum and rhizoma polygonati zingiberis according to different characters, and is widely distributed all over the country. The sealwort has a long history of use and has high medicinal value and edible value. Originally recorded in Lei Gong processing Lun, the records of both medical and edible aspects are recorded in Shen nong's herbal Jing, Ming Yi Bie Lu, Ben Cao gang mu and Qing Yang county, and the characteristics of homology of medicine and food of rhizoma Polygonati are reflected. The main chemical components of the composition are polysaccharides, steroidal saponins, flavonoids, alkaloids, quinone compounds, lignans, phytosterol, volatile components, amino acids, trace elements and other small molecular compounds. Has effects of nourishing yin, invigorating qi, invigorating spleen, moistening lung, and invigorating kidney, and can be used for treating weakness of spleen and stomach, asthenia, anorexia, lung deficiency, cough, essence and blood deficiency, and internal heat diabetes.
The Chinese medicinal paste is a Chinese patent medicine with nourishing and preventing effects, also called as 'soft extract' and 'soft extract'. The thick semifluid or jelly ointment is prepared by establishing different prescriptions according to the respective constitution and clinical manifestation difference of different people on the basis of large compound decoction, and adding specific auxiliary materials after decocting and concentrating. The ointment has different preparation methods, diversified prescriptions, convenient use, special effects different from other drug forms in keeping health status and regulating organism balance, and has thousands of years of history in China. The decoction is prepared by decocting decoction pieces with water, concentrating the decoction, and adding Mel or sugar to obtain semi-fluid preparation. Where it is desired to add a powder, it is typically a very fine powder unless otherwise specified.
The rhizoma polygonati paste has long-term sources, is used as the essence of precious heritage and Chinese medicine culture of the Chinese medicine, and has special effect on preventing diseases. With the improvement of the social living standard, people pay more and more attention to health preservation and health care, and the traditional Chinese medicine ointment formula business is developed at a rapid speed in the whole country. Under the guidance of the theory system of traditional Chinese medicine, sealwort and other traditional Chinese medicines and ingredients are commonly used to develop sealwort ointment with different efficacies, such as papaya sealwort ointment, sealwort-mulberry ointment, ginseng sealwort ointment, sealwort-oyster ointment and the like. However, the existing rhizoma polygonati paste has the defects of poor quality stability, poor health care effect on the spleen and stomach, poor sensory properties, short shelf life, difficult subpackage and the like due to improper processing method of rhizoma polygonati, improper types of added auxiliary materials and/or unreasonable soaking, decocting times and concentration density of traditional Chinese medicinal materials in the production process, and the large-scale production, popularization and application of the rhizoma polygonati paste are seriously influenced.
Disclosure of Invention
The invention aims to overcome the defects of poor sensory property and poor health-care effect on the spleen and stomach of the existing sealwort paste, and provides sealwort paste and a preparation method thereof; the rhizoma Polygonati paste has good health promotion function for spleen and stomach, good organoleptic properties, simple preparation method, easy edible and long-term storage, and is beneficial for large-scale production, popularization and application of rhizoma Polygonati paste.
In order to realize the aim, the invention provides a rhizoma polygonati paste which is mainly prepared from the following raw materials in percentage by weight: 40-60 parts of rhizoma polygonati, 140-160 parts of white granulated sugar, 50-70 parts of sweet potato starch, 30-50 parts of lotus root starch and 5-10 parts of edible gelatin.
The rhizoma polygonati paste disclosed by the invention not only obviously enhances the health care function of the rhizoma polygonati paste on the spleen and the stomach through the reasonable compatibility of the rhizoma polygonati, the sweet potato powder and the lotus root starch, but also can effectively prevent and treat the diseases of the spleen and the stomach; the added white granulated sugar and edible gelatin are also utilized, so that the cream has better formability, light sweet taste, obviously improved sensory properties, convenient sealing, subpackaging and eating and longer quality guarantee period, thereby being beneficial to the large-scale production, popularization and application of the polygonatum cream.
The sweet potato powder is sweet and mild in taste and non-toxic, contains a large amount of mucin, and has the effects of tonifying spleen, regulating qi, stopping diarrhea, tonifying kidney and benefiting lung; the advantages are that: the sweet potato powder is convenient to transport and store; the sweet potato powder can increase the consistency of the rhizoma polygonati cream, so that the obtained cream is easier to form; the inspection items of the rhizoma polygonati paste can be reduced, such as: the inspection of relative density can be avoided, and the inspection items of insoluble substances can be simplified.
Wherein the white granulated sugar has sweet taste and mild nature, and the main component is sucrose. The granules are uniform and crystalline, white in color and pure in sweet taste. The white granulated sugar has the health care functions of arresting sweating, nourishing yin, tonifying qi, strengthening the middle warmer, moistening lung and harmonizing stomach, is cheap and easily available, is convenient to take and use quantitatively, has the effects of correcting flavor and bonding, is smaller in addition amount, and has a positive effect of reducing the breeding of bacteria.
The lotus root starch is sweet in taste and neutral in nature, is rich in mucin, dietary fiber and tannin, has the functions of promoting digestion, nourishing blood and tonifying, tonifying stomach and spleen and the like, and is mainly used for treating inappetence, vexation, lung heat, thirst, dryness, poor spleen and stomach and the like; is rich in trace metal elements necessary for human body such as iron and calcium, and also contains a large amount of plant protein, vitamins and starch, and can help digestion, prevent constipation, prevent atherosclerosis, and improve immunity of organism. The lotus root starch can increase the viscosity of the rhizoma polygonati paste and is beneficial to forming the rhizoma polygonati paste; the lotus root powder is matched with the sealwort, so that the appetite is increased and the health care effect is increased while the tonifying and deficiency tonifying are realized.
Among them, edible gelatin is one of the most common additives in the food industry, and is often used as an excipient or additive. The collagen protein is prepared by using fresh animal skin and bone through the dozens of working procedures of classification, degreasing, rinsing, neutralization and the like, is light yellow small blocks or powder, and is odorless and tasteless; can assist the rhizoma polygonati paste to be rapidly molded and improve the sensory properties of the rhizoma polygonati paste.
Preferably, the sealwort ointment is mainly prepared from the following raw materials in percentage by weight: 50 parts of rhizoma polygonati, 150 parts of white granulated sugar, 60 parts of sweet potato starch, 40 parts of lotus root starch and 8 parts of edible gelatin; the prepared polygonatum sibiricum paste has the best sensory property and the best health-care effect on the spleen and the stomach.
Wherein, the rhizoma polygonati is preferably four-steamed four-sun-dried rhizoma polygonati; the optimized four-steaming and four-sun-drying rhizoma polygonati not only eliminates the numb taste, reduces the irritation to the throat and ensures that the sensory property of the rhizoma polygonati cream is better; moreover, the four-steaming and four-drying processing increases the dissolution rate of the traditional Chinese medicine components of the rhizoma polygonati during extraction, so that the content of the medicinal components in the rhizoma polygonati paste is higher, and the health-care effect of the rhizoma polygonati paste is better.
The preparation method of the four-steaming four-sun-drying rhizoma polygonati comprises the following steps:
(1) removing impurities and fibrous roots from fresh rhizoma Polygonati, cleaning, air drying, drying at 30-50 deg.C to water content of 25-40%, taking out, cutting into 5-10mm thick pieces, and drying at 40 deg.C to water content of 15-24%;
(2) steaming the dried rhizoma polygonati slices in the step 1 in a steaming container for 4-8h, taking out, and drying in hot air at 55-80 ℃ until the moisture content is 12-18%, thus obtaining the rhizoma polygonati which is steamed and dried in the sun;
(3) repeating the step 2 for 3 times to obtain four-steaming and four-sun-drying rhizoma Polygonati.
Wherein, in the step 1, the slice thickness of rhizoma polygonati is 5-9mm, preferably 6-8 mm.
Further, in the process of steaming rhizoma polygonati, the first 2 times of steaming are performed by steaming with strong fire, the second 2 times of steaming are performed by steaming with slow fire, and the steaming is performed for 4 times in total.
Preferably, the temperature of steam in the steaming container is more than or equal to 100 ℃ in the process of steaming with strong fire.
Preferably, in the process of steaming with slow fire, the temperature of steam in the steaming container is 98-100 ℃.
Further, step 2, placing the dried polygonatum sibiricum slices into a steaming container, steaming for 5-7h, and then drying by hot air at 57-65 ℃ until the moisture content is 12-18%, thus obtaining the polygonatum sibiricum which is steamed and dried in the sun.
Further, in step 2-3, after each time of steaming sealwort, drying to gradually increase the degree of reduction of the moisture content, namely, the moisture content of the dried sealwort after the first time of steaming reaches 12-18%, the moisture content of the dried sealwort after the second time of steaming is lower than that of the first time, the third time is lower than that of the second time, and the fourth time is lower than that of the third time. And (5) drying the polygonatum sibiricum after the fourth steaming until the moisture content is 7-12%. During each steaming, the components such as colloid, cell sap, mucilage and the like in the rhizoma polygonati are gradually steamed and released, and through continuous steaming and drying treatment, the components with side effects in the rhizoma polygonati are better removed, and the components such as polysaccharide, 5-HMF, diosgenin and the like are converted or released.
In order to achieve the above object, the present invention further provides a method for preparing a rhizoma polygonati paste, comprising the steps of:
(1) soaking rhizoma Polygonati in 9-11 times of water for 3-5 hr, heating and boiling for 1-2 hr, filtering, and collecting filtrate; decocting the residue with 7-9 times of water for 2 times, each time heating and boiling for 1-2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving white sugar with 0.4-0.8 times of water, heating and stirring to golden yellow to obtain refined sugar;
dissolving lotus root starch in cold water, stirring to obtain slurry, adding boiling water, and stirring to obtain thick paste to obtain lotus root starch paste;
swelling edible gelatin with water, and heating to form gelatin solution;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Preferably, in the step (1), the total amount of water added into the lotus root starch is 3-5 times of the weight of the lotus root starch; the ratio of cold water to boiling water is 1-2: 1-2; the lotus root starch is not easy to agglomerate due to the preferable water adding amount, so that the obtained lotus root starch paste is moderate in viscosity and better in taste, and the prepared polygonatum rhizome paste is better in sensory property.
Wherein, the original volume in the step (1) and the step 1 refers to the total volume of the combined rhizoma polygonati filtrates obtained in three times.
Wherein, preferably, in the step (1), the amount of water added into the edible gelatin is 0.5-1 time of that of the edible gelatin; the heating temperature is 75 ℃; the optimal water adding amount and heating temperature are selected, the edible gelatin has the best solubility, the obtained gelatin solution has moderate viscosity, and the prepared polygonatum sibiricum paste has better sensory properties.
Wherein, in the step (2), the heating temperature is preferably 90-100 ℃; the preferable heating temperature condition has better solubility of the refined sugar and the sweet potato starch, and the prepared polygonatum paste has better sensory properties.
Compared with the prior art, the invention has the beneficial effects that:
1. the rhizoma polygonati paste disclosed by the invention is reasonably compatible, so that the health care function of the rhizoma polygonati paste on the spleen and the stomach is remarkably enhanced, and the spleen and stomach diseases can be effectively prevented and treated.
2. The sealwort paste disclosed by the invention utilizes the added white granulated sugar and edible gelatin, so that the paste has better formability, has light fragrant and sweet taste, is obviously improved in sensory properties (the sensory properties are more than 80), is convenient to seal, subpackage and eat, and is longer in quality guarantee period.
3. The four-steaming and four-sun-drying rhizoma polygonati preferably selected from the rhizoma polygonati paste disclosed by the invention not only eliminates the numb taste, reduces the irritation to the throat and enables the sensory properties of the rhizoma polygonati paste to be better; the dissolution rate of traditional Chinese medicine components of rhizoma polygonati during extraction is higher, the content of medicinal components in the rhizoma polygonati paste is higher, and the health care effect of the rhizoma polygonati paste is better.
4. The preparation method is simple and reliable, and the prepared polygonatum paste has good health care function on the spleen and the stomach and good sensory properties, and is suitable for large-scale and industrial production of the polygonatum paste.
Detailed Description
The present invention will be described in further detail with reference to test examples and specific embodiments, but it should not be construed that the scope of the above-described subject matter of the present invention is limited to the following examples, and that techniques realized based on the contents of the present invention are within the scope of the present invention.
Example 1:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Example 2:
(1) soaking 40g of four-steamed and four-sun-dried rhizoma Polygonati in 9 times of water for 3h, heating and boiling for 2h, filtering, and collecting filtrate; decocting the residue with 7 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 140g of white granulated sugar with 0.8 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 30g of lotus root starch in 60g of cold water, stirring to obtain slurry, adding 30g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 5g of edible gelatin with 5g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 50g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Example 3:
(1) soaking 60g of four-steamed and four-sun-dried rhizoma Polygonati in 11 times of water for 5h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 9 times of water for 2 times, each time boiling for 1 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 160g of white granulated sugar with 0.4 times of water, heating and stirring until the white granulated sugar is golden yellow to obtain refined sugar for later use;
dissolving 50g of lotus root starch in 125g of cold water, stirring to obtain slurry, adding 125g of boiling water, and stirring to obtain a viscous paste to obtain lotus root starch paste for later use;
swelling 10g of edible gelatin with 10g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 70g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Example 4:
(1) soaking 50g of conventional rhizoma Polygonati in 10 times of water for 4 hr, heating and boiling for 1 hr, filtering, and collecting filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Comparative example 1:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of black sesame powder in 80g of cold water, stirring to form slurry, adding 80g of boiling water, and stirring to form viscous paste to obtain black sesame paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding semen Sesami Niger paste and gelatin solution, stirring, mixing, and cooling to obtain rhizoma Polygonati paste.
Comparative example 2:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of brown sugar in 0.5 times of water, heating and stirring to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Comparative example 3:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring, mixing, adding 60g potato starch, stirring, and mixing; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Comparative example 4:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 180g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Comparative example 5:
(1) soaking 50g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 80g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Comparative example 6:
(1) soaking 70g of four-steamed and four-sun-dried rhizoma Polygonati in 10 times of water for 4h, heating and boiling for 1h, and filtering to obtain filtrate; decocting the residue with 8 times of water for 2 times, each time boiling for 2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving 150g of white granulated sugar with 0.5 times of water, heating and stirring to be golden yellow to obtain refined sugar for later use;
dissolving 40g of lotus root starch in 80g of cold water, stirring to obtain slurry, adding 80g of boiling water, and stirring to obtain viscous paste to obtain lotus root starch paste for later use;
swelling 8g of edible gelatin with 8g of water, heating to 75 ℃, and stirring to dissolve to form a gelatin solution for later use;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding 60g sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
Experimental example:
1. sensory property evaluation experiment:
the experimental method comprises the following steps: the sensory evaluation method is a main food texture evaluation means, has strong subjectivity and poor reliability. In order to improve the reliability of sensory evaluation, the polygonatum sibiricum paste prepared by the invention consists of 10 appraisers, wherein 5 men and 5 women. The evaluation is carried out about one to two hours after meals, food with heavy smell is not eaten within half an hour before tasting, the paste formula is evaluated after gargling with purified water, and the evaluation place is bright and has no peculiar smell, thereby not influencing light judgment and interfering smell sense. The resulting scores will be corroborated using statistical principles.
TABLE 1 sensory Scoring criteria
TABLE 2 results of the experiment
| Serial number | Sensory character score |
| Example 1 | 81.38 |
| Example 2 | 81.25 |
| Example 3 | 80.87 |
| Example 4 | 80.12 |
| Comparative example 1 | 71.82 |
| Comparative example 2 | 74.36 |
| Comparative example 3 | 79.25 |
| Comparative example 4 | 72.28 |
| Comparative example 5 | 73.81 |
| Comparative example 6 | 74.92 |
2. And (3) pharmacodynamic experiment: influence of rhizoma Polygonati extract on MTL and GAS of spleen deficiency rat
2.1. Method of producing a composite material
2.1.1 Molding
According to the proportion of magnolia officinalis, immature bitter orange and rhubarb =3: 3: 2, soaking in cold water for 20 minutes, decocting the magnolia officinalis and the immature bitter orange for 10 minutes first, then decocting the rhubarb for 10 minutes, repeatedly decocting for 2 times, filtering, and combining the filtrates. Concentrating in 60 deg.C constant temperature water bath to 1g/ml, and storing in 4 deg.C refrigerator for use. The medicine is administered every other day for 1 time with 4ml/2OOg weight, and is fed for 42 days with no limitation on drinking water and no limitation on feeding; the blank group was administered with 4mL of physiological saline every other day for 42 consecutive days.
2.1.2 methods of administration:
after the model building is finished, healthy SD model building rats (provided by laboratory animal research institute of people hospital of Sichuan province of Sichuan medical academy of Sichuan province, production license number: SCXK (Sichuan) 2018-24, and 10 rats in each group are randomly divided into two groups for experiment. The first group includes: a model group, a normal group, a high dose group of rhizoma polygonati cream (example 1), a medium dose group of rhizoma polygonati cream (example 1), a low dose group of rhizoma polygonati cream (example 1) and 6 administration groups of four monarch granule positive control group (Guangzhou Noojin pharmaceutical Co., Ltd. batch No. 8361A 02), wherein the administration groups are all administered on the 43 th day after the model is made, the administration groups are sequentially and respectively administered by intragastric gavage for 3.76, 7.52 and 15.04g/kg, and the model group and the blank group are administered with 4ml of physiological saline 1 time a day for 7 consecutive days; the second group includes: 6 administration groups of the model group, the normal group, the experimental group (example 1), the control group 1 (comparative example 1), the control group 2 (comparative example 2), and the control group 3 (comparative example 3); the medicine is administrated on the 43 th day after the model building, 15.04g/kg of medicine is administrated by intragastric administration in each administration group, and 4ml of normal saline is administrated in the model group and the blank group 1 time a day for 7 days continuously. Collecting 2mL of blood from eyeball 1h after last intragastric administration, placing in a dry test tube, and centrifuging at 4 deg.C for 15min (3500 r/min); and taking another 2mL of blood, fully and uniformly mixing the blood in test tubes with 30 muL of each of 10% of disodium ethylene diamine tetraacetate and aprotinin, centrifuging the mixture for 10 min (3500 r/min) at 4 ℃, and storing the serum and the plasma in a refrigerator at 20 ℃ below zero for later test.
2.1.3 Observation index
2.1.3.1 general index observations in the experiments, the hair color, activity, feces, etc. of each group of animals were observed.
The method comprises the steps of determining a 2.1.3.2 MTL value, setting standard holes and sample holes in a cleaned micropore ELISA plate, adding 640 mu L, 320 mu L, 160 mu L, 80 mu L, 40 mu L and 20 mu L of a mLMTL standard substance into the standard holes, adding 40 mu L of sample diluent into the sample holes, adding 10 mu L of plasma, then adding 100 mu L of detection antibody marked by horseradish peroxidase (HRP) into each of the standard holes and the sample holes, sealing reaction holes by a sealing plate film, and incubating for 60min in a 37 ℃ water bath or a constant temperature box. Discarding liquid, beating the water absorption paper to be dry, filling washing liquid into each hole, standing for 1min, throwing off the washing liquid, beating the water absorption paper to be dry, repeating the plate washing for 5 times, adding 50 mu L of substrate A, B into each hole, incubating for 15min at 37 ℃ in a dark place, adding 50 mu L of stop solution into each hole, adjusting to zero in a blank air way within 15min, and measuring the OD value of each hole at the wavelength of 450nm of the microplate reader. And taking the concentration of the standard substance as an abscissa and taking the corresponding OD value as an ordinate, drawing a linear regression curve of the standard substance, calculating the concentration value of each sample according to a curve equation, and multiplying the concentration value by a dilution multiple to obtain the actual concentration of the sample.
2.1.3.3 GAS value is measured, a standard hole and a sample hole are arranged on a cleaned micropore ELISA plate, 50 muL of 80, 40, 20, 10 and 5ng/mLGAS standard substance is added into the standard hole, 40 muL of sample diluent is added into the sample hole, 10 muL of serum is added, and the plate is sealed by a sealing plate membrane and then incubated for 30min at 37 ℃. Diluting 30 times of concentrated washing liquid with 30 times of distilled water for later use, carefully removing the sealing plate membrane, discarding liquid, spin-drying, filling each hole with washing liquid, standing for 30s, discarding, repeating the above steps for 5 times, and patting to dry. Adding 50 mu L of enzyme labeling reagent into each hole, except for blank holes, incubating and washing the blank holes in the same way, adding a color developing agent A50 mu L into each hole, adding a color developing agent B50 mu L, lightly shaking and uniformly mixing, performing light-shielding color development at 37 ℃ for 15min, adding 50 mu L of stop solution into each hole, and determining and calculating the actual concentration of each sample in the same way.
2.1.4 statistical analysis
SPSS16.0 statistical software is adopted for data processing, the data of each group are represented by means of the mean number +/-standard deviation (+/-s), the single-factor variance analysis is carried out, and the mean numbers are compared pairwise.
2.2 results
2.2.1 analysis of the first set of experimental results:
2.2.1.1 Effect on general indices: the hair color of the rats in the model group turns yellow, withered and lusterless, the hair color of the administration group is almost recovered to be normal, which shows that spleen deficiency affects the fur color of animals, and the sealwort ointment has a recovery effect on the fur color of rats with spleen deficiency. In addition, the times of defecation, the number of loose stools, the rate of loose stools and the size of fecal pellets of the spleen-deficiency mice are obviously increased, and the number of loose stools and the size of fecal pellets are all reduced after administration, which shows that the rhizoma polygonati cream has a regulating effect on gastrointestinal excretion of the spleen-deficiency mice.
2.2.1.2 Effect of Polygonatum sibiricum ointment on MTL and GAS in blood plasma
After the model is made, the MTL level of the spleen-deficient rat is obviously reduced, and the difference between the model group and the normal group has statistical significance (P is less than 0.01); the difference between the high-dose group and the model group of the rhizoma polygonati ointment has significant statistical significance (P <0.01), and the difference between the low-dose group and the medium-dose group of the rhizoma polygonati ointment and the four-monarch-seed positive control group and the model group has statistical significance (P < 0.05).
The effect of the rhizoma polygonati cream on the serum GAS of the rat is that the level of the serum GAS of the spleen-deficient rat is obviously reduced after the model is made; the difference between the model group and the normal group is significant statistically (P < 0.01). The difference of the high-concentration group of the rhizoma polygonati extract and the model group has statistical significance (P is less than 0.01), the low-concentration group and the medium-concentration group of the four-monarch-seed granules and the rhizoma polygonati extract and the model group (P is less than 0.05), and the high-concentration group is basically recovered to be normal from the data. The results are shown in Table 3.
TABLE 3 Effect of Huangjing ointment on MTL and GAS in rats with spleen deficiency (± s, n ═ 10)
| Group of | Dosage (g/kg) | MTL（pg/mL） | GAS（pg/mL） |
| Normal control group | Physiological saline | 206.32±22.94 | 52.02±3.03 |
| Model set | Physiological saline | 167.20±18.11** | 44.01±3.10** |
| Positive control group | 4.5 | 181.35±9.21△ | 48.72±2.62△ |
| Low dose of HUANGJING ointment | 3.76 | 178.49±23.67 | 49.26±3.38△ |
| Middle dose of rhizoma Polygonati extract | 7.52 | 181.50±10.88△ | 49.74±4.58△ |
| High dose of rhizoma Polygonati extract | 15.04 | 193.98±10.01△△ | 50.52±2.75△△ |
Note: p <0.01 compared to normal group; compared with the model group, the delta P is less than 0.05 and the delta P is less than 0.01.
From the theory of traditional Chinese medicine, the functions of transportation, transformation and ascending of clear of the spleen are affected, the functions of digestion and absorption are poor, qi and blood are lack of source, and qi deficiency drives qi to move and is weak, so that various gastrointestinal movements are slowed down. The MTL can obviously promote gastric motility and electrogastrosis activity and has lasting effect; GAS also has a significant effect in promoting gastric emptying. The first set of experiments showed that: the sealwort ointment in the embodiment 1 of the invention can basically restore the reduced MTL and GAS to the normal level, and proves that the sealwort ointment can restore the disordered gastrointestinal movement of spleen-deficient animals by adjusting the MTL and GAS levels.
2.2.2 analysis of the second set of experimental results:
2.2.2.1 Effect on general indices
Influence on general indices: the hair color of the rats in the model group turns yellow, withered and lusterless, and the hair color of the rats in the experimental group is almost recovered to be normal, which shows that spleen deficiency affects the color of animal fur, and the effect of the ointment of rhizoma polygonati in example 1 on the color of the fur of the rats with spleen deficiency is better; the fur color of the mice in the control group is recovered, but a certain difference is still existed compared with the experimental group, which indicates that the efficacy of the rhizoma polygonati cream in the comparative examples 1-3 is lower than that in the example 1. In addition, the times of defecation, the number of loose stools, the rate of loose stools and the size of fecal pellets of the spleen-deficiency mice are obviously increased, and the number of the loose stools and the size of the fecal pellets are all reduced after administration, which shows that the sealwort ointment in the experimental example and the comparative example has a regulating effect on gastrointestinal excretion of the spleen-deficiency mice.
2.2.1.2 Effect of Polygonatum sibiricum ointment on MTL and GAS in blood plasma
After the model is made, the MTL level of the spleen-deficient rat is obviously reduced, and the difference between the model group and the normal group has statistical significance (P is less than 0.01); the difference between the experimental group and the model group has significant statistical significance (P <0.01), and the difference between the control group 1-3 and the model group has statistical significance (P < 0.05).
The effect of the rhizoma polygonati cream on the serum GAS of the rat is that the level of the serum GAS of the spleen-deficient rat is obviously reduced after the model is made; the difference between the model group and the normal group is significant statistically (P < 0.01). The differences were statistically significant (P <0.01) in the experimental group compared to the model group, and the experimental group returned to normal substantially from the data point of view when the control groups 1-3 were compared to the model group (P < 0.05). The results are shown in Table 4.
TABLE 4 Effect of Huangjing ointment on MTL and GAS in rats with spleen deficiency (± s, n ═ 10)
| Group of | Dosage (g/kg) | MTL（pg/mL） | GAS（pg/mL） |
| Normal control group | Physiological saline | 204.80±20.19 | 51.72±2.54 |
| Model set | Physiological saline | 165.71±15.83** | 43.87±3.61** |
| Experimental group | 15.04 | 195.15±9.75△△ | 51.01±2.43△△ |
| Control group 1 | 15.04 | 177.62±18.13△ | 48.19±2.82△ |
| Control group 2 | 15.04 | 193.80±9.48△△ | 50.71±3.51△△ |
| Control group 3 | 15.04 | 181.52±14.75△ | 48.54±3.12△ |
Note: p <0.01 compared to normal group; compared with the model group, the delta P is less than 0.05 and the delta P is less than 0.01.
The experiment shows that: the lotus root starch and the sweet potato starch in the rhizoma polygonati cream are compatible with rhizoma polygonati, have a synergistic interaction effect, can obviously improve the health-care function of the rhizoma polygonati cream on the spleen and the stomach, and effectively prevent and treat the diseases of the spleen and the stomach.
Claims (10)
1. The sealwort paste is characterized by being mainly prepared from the following raw materials in percentage by weight: 40-60 parts of rhizoma polygonati, 140-160 parts of white granulated sugar, 50-70 parts of sweet potato starch, 30-50 parts of lotus root starch and 5-10 parts of edible gelatin.
2. The sealwort paste according to claim 1, wherein the sealwort paste is mainly prepared from the following raw materials in percentage by weight: 50 parts of rhizoma polygonati, 150 parts of white granulated sugar, 60 parts of sweet potato starch, 40 parts of lotus root starch and 8 parts of edible gelatin.
3. The sealwort paste according to claim 1, wherein the sealwort is four-steaming and four-sun-drying sealwort.
4. The sealwort paste according to claim 3, wherein the preparation method of the four-steaming four-sun-drying sealwort comprises the following steps:
(1) removing impurities and fibrous roots from fresh rhizoma Polygonati, cleaning, air drying, drying at 30-50 deg.C to water content of 25-40%, taking out, cutting into 5-10mm thick pieces, and drying at 40 deg.C to water content of 15-24%;
(2) steaming the dried rhizoma polygonati slices in the step 1 in a steaming container for 4-8h, taking out, and drying in hot air at 55-80 ℃ until the moisture content is 12-18%, thus obtaining the rhizoma polygonati which is steamed and dried in the sun;
(3) repeating the step 2 for 3 times to obtain four-steaming and four-sun-drying rhizoma Polygonati.
5. The rhizoma polygonati cream according to claim 4, wherein in the steaming process of rhizoma polygonati, the first 2 times of steaming are performed by steaming with strong fire, the last 2 times of steaming are performed by steaming with slow fire, and the steaming is performed for 4 times in total.
6. The sealwort paste according to claim 4, wherein in the step (2), the dried sealwort slices are placed in a steaming container, steamed for 5-7h, and then hot-air dried at 57-65 ℃ until the moisture content is 12-18%, so that the sealwort is obtained by steaming and sun drying.
7. The rhizoma polygonati paste according to claim 4, wherein in steps (2) and (3), after each time of steaming, the rhizoma polygonati is dried to gradually increase the degree of reduction of the moisture content, namely, the moisture content of the dried rhizoma polygonati after the first steaming is 12-18%, the moisture content of the dried rhizoma polygonati after the second steaming is lower than that of the first steaming, the moisture content of the dried rhizoma polygonati is lower than that of the third steaming, and the moisture content of the dried rhizoma polygonati is lower than that of the fourth steaming.
8. A method for preparing a goldthread extract according to any one of claims 1 to 7, comprising the steps of:
(1) soaking rhizoma Polygonati in 9-11 times of water for 3-5 hr, heating and boiling for 1-2 hr, filtering, and collecting filtrate; decocting the residue with 7-9 times of water for 2 times, each time heating and boiling for 1-2 hr, filtering, and collecting filtrate; mixing the filtrates obtained 3 times, and concentrating to 1/6 of the original volume to obtain rhizoma Polygonati fluid extract;
dissolving white sugar with 0.4-0.8 times of water, heating and stirring to golden yellow to obtain refined sugar;
dissolving lotus root starch in cold water, stirring to obtain slurry, adding boiling water, and stirring to obtain thick paste to obtain lotus root starch paste;
swelling edible gelatin with water, and heating to form gelatin solution;
(2) adding refined sugar into the rhizoma Polygonati fluid extract under heating condition, stirring and mixing well, adding sweet potato starch, stirring and mixing well; stopping heating, sequentially adding the lotus root starch paste and the gelatin solution, stirring and mixing uniformly, and cooling to obtain the sealwort paste.
9. The preparation method according to claim 8, wherein in the step (1), the total amount of water added into the lotus root starch is 3-5 times of the weight of the lotus root starch; the ratio of cold water to boiling water is 1-2: 1-2.
10. The method according to claim 8, wherein the amount of water added to the edible gelatin in step (1) is 0.5 to 1 times that of the edible gelatin.
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