CN110585239B

CN110585239B - Plaster and preparation method and application thereof

Info

Publication number: CN110585239B
Application number: CN201911068289.XA
Authority: CN
Inventors: 王波林
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-06
Filing date: 2019-11-06
Publication date: 2021-07-02
Anticipated expiration: 2039-11-06
Also published as: CN110585239A

Abstract

The invention discloses a plaster and a preparation method and application thereof, belonging to the technical field of medicines. The plaster comprises: tourmaline, fullerene and herbal essence. Wherein, the hundred herb essences comprise: radix et rhizoma Rhei, herba Centellae oil, fel Ursi, emu oil, folium Et cacumen Murrayae, flos Magnoliae, herba Senecionis Cannabifolii, herba Senecionis Scandentis, radix Angelicae sinensis, radix Notoginseng, fructus Amomi, radix Angelicae Pubescentis, flos Chrysanthemi Indici, rhizoma Cyperi, radix Angelicae Dahuricae, flos Lonicerae, herba Elephantopi scaberis, radix Saposhnikoviae, and dipotassium glycyrrhizinate. The plaster prepared by adding the tourmaline, the fullerene and the herbal essence containing a plurality of traditional Chinese medicine components has no toxic or side effect, and has a plurality of effects of expelling cold and dampness, dredging channels and collaterals, resisting aging, refreshing, activating blood circulation to dissipate blood stasis, nourishing hair, growing hair, removing freckles, beautifying and the like.

Description

Plaster and preparation method and application thereof

Technical Field

The invention relates to the technical field of medicines, in particular to a plaster and a preparation method and application thereof.

Background

The plaster is a colloidal substance decocted by vegetable oil or animal oil in combination with a medicament, and can be externally applied to a patient to achieve a certain treatment effect.

However, the efficacy of the currently marketed external plasters is relatively single. Among them, the conventional plaster for treating skin contusion, nourishing and growing hair and removing skin stains has problems of treatment effect and the like. Therefore, there is a need to develop a plaster.

Disclosure of Invention

An object of an embodiment of the present invention is to provide a plaster to solve the problems mentioned in the background art.

In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:

a plaster comprises the following components in parts by weight: 2-7 parts of tourmaline, 5-15 parts of fullerene and 10-20 parts of herbal essence.

Preferably, the plaster comprises the following components in parts by weight: 4-6 parts of tourmaline, 8-12 parts of fullerene and 13-17 parts of herbal essence.

Preferably, the herbal essence comprises the following components in parts by weight: 5-15 parts of herbal oil, 3-7 parts of bear gall, 15-25 parts of emu oil, 4-8 parts of murraya jasminorage, 4-8 parts of magnolia flower, 4-8 parts of hempleaf groundsel herb, 4-8 parts of senecio scandens, 4-8 parts of angelica sinensis, 4-8 parts of pseudo-ginseng, 4-8 parts of fructus amomi, 4-8 parts of radix angelicae pubescentis, 1-5 parts of wild chrysanthemum flower, 1-5 parts of rhizoma cyperi, 1-5 parts of radix angelicae, 1-5 parts of honeysuckle, 1-5 parts of elephantopus scaber, 1-5 parts of radix sileris and 40-60 parts of dipotassium glycyrrhizinate.

Preferably, the herbal essence comprises the following components in parts by weight: 8-12 parts of herbal oil, 4-6 parts of bear gall, 18-22 parts of emu oil, 5-7 parts of murraya jasminorage, 5-7 parts of magnolia flower, 5-7 parts of hempleaf groundsel herb, 5-7 parts of senecio scandens, 5-7 parts of angelica sinensis, 5-7 parts of pseudo-ginseng, 5-7 parts of fructus amomi, 5-7 parts of radix angelicae pubescentis, 2-4 parts of wild chrysanthemum flower, 2-4 parts of rhizoma cyperi, 2-4 parts of radix angelicae, 2-4 parts of honeysuckle, 2-4 parts of elephantopus scaber, 2-4 parts of radix sileris and 45-55 parts of dipotassium glycyrrhizinate.

Another object of the embodiments of the present invention is to provide a method for preparing the above plaster, which comprises the following steps:

weighing tourmaline, fullerene and herbal essence according to the weight parts for later use;

mixing the tourmaline, the fullerene and the herbal essence to obtain a mixture;

and mixing the mixture with hydrogel to prepare the plaster.

Preferably, in the step, the mass ratio of the mixture to the hydrogel is (2-4) to (6-8).

Another object of the embodiments of the present invention is to provide a plaster prepared by the above preparation method.

Another object of the embodiments of the present invention is to provide a use of the above-mentioned plaster for preparing a medicament for treating skin contusion.

The embodiment of the invention also aims to provide application of the plaster in preparing a hair growth promoting medicine.

The embodiment of the invention also aims to provide application of the plaster in preparing a freckle removing medicine.

Wherein, the pharmacology of each component is as follows:

bear gall, main components: contains ursodeoxycholic acid; the pharmacological action is as follows: clearing heat, diminishing inflammation, relieving pain, and tranquilizing; nature and taste: bitter and cold. Meridian tropism: enter liver, gallbladder and heart meridians. The functions are as follows: clear heat and remove toxicity, improve eyesight and stop convulsion. The main treatment is as follows: conjunctival congestion, epilepsy with convulsion due to febrile disease, infantile convulsions, malignant sores, carbuncles, and swelling.

Murraya paniculata, nature and taste: mild in nature and bitter in taste; the functions are as follows: relieving pain and arresting bleeding; the main treatment is as follows: traumatic injury; toothache.

Flos Magnoliae, pungent and warm; entering lung and stomach meridians; the main treatment is as follows: relieving stuffy nose, and treating nasosinusitis headache, nasal obstruction, smelling neither smell nor odor, frequent nasal discharge, etc.; dispelling wind-cold, and can be used for treating wind-cold exterior syndrome, wind-cold type common cold, headache and nasal obstruction. It is often combined with Fang Feng, Bai Zhi and cang Er Zi.

Herb of common Cnaphalium, nature and flavor: bitter and astringent, and neutral. The functions are mainly as follows: remove toxicity, relieve swelling and stop bleeding. It can be used for treating wound, undefined lump, snake bite, and scorpion sting.

Groundsel, nature and taste: bitter and cold. Meridian tropism: enter liver and lung meridians. The functions are as follows: clearing away heat and toxic material, removing liver heat, improving eyesight, cooling blood, and relieving swelling. The main treatment is as follows: upper respiratory infection, tonsillitis, pharyngolaryngitis, pneumonia, conjunctivitis, dysentery, enteritis, appendicitis, acute lymphadenitis, influenza, septicemia, erysipelas, furuncle, and trichomonas vaginalis.

Angelica sinensis, nature and taste: sweet, bitter, pungent and warm. Meridian tropism: enter heart, liver and spleen meridians. The functions are as follows: enriching blood, promoting blood circulation, regulating menstruation, moistening dryness, and lubricating intestines. The main treatment is as follows: menoxenia, blood deficiency or blood stasis amenorrhea, dysmenorrhea metrorrhagia, traumatic injury, carbuncle, cellulitis, swelling and pain, rheumatic arthralgia, and blood deficiency with constipation.

Pseudo-ginseng, nature and taste: sweet, slightly bitter and warm. Meridian tropism: enter liver and stomach meridians. The functions are as follows: stop bleeding, resolve stasis, resolve swelling and stop bleeding. The main treatment is as follows: traumatic swelling, pain and bleeding, hematemesis, bloody flux, metrorrhagia and metrostaxis, postpartum abdominal pain due to blood stasis, carbuncle, swelling and sore.

Amomum fruit, nature and taste: pungent and warm. Meridian tropism: enter spleen, stomach and kidney meridians. The functions are as follows: regulate qi-flowing, relieve depression, stimulate appetite, promote digestion and prevent abortion. The main treatment is as follows: distending pain of stomach and abdomen, qi stagnation and indigestion, emesis, diarrhea, dysentery, threatened abortion, etc.

Pubescent angelica root, nature and taste: pungent, bitter and slightly warm. Meridian tropism: it enters kidney meridian. The functions are as follows: dispelling pathogenic wind, removing dampness, and relieving pain. The main treatment is as follows: headache due to wind, arthralgia of waist and knee.

Wild chrysanthemum, nature and taste: cool in nature and bitter in taste. The functions are as follows: clearing away heat and removing sore-toxin. The main treatment is as follows: wind-heat dizziness and headache; sores and ulcers.

Cyperus rotundus, nature and taste: pungent, slightly bitter and mild. Meridian tropism: enter liver and triple energizer meridians. The functions are as follows: regulating qi-flowing, resolving stagnation, regulating menstruation, and relieving pain. The main treatment is as follows: disharmony between the liver and stomach, qi stagnation, fullness and distention in the chest and abdomen, irregular menstruation, dysmenorrhea, etc.

Radix angelicae, nature and taste: pungent and warm in nature. Meridian tropism: enter lung and stomach meridians. The functions are as follows: relieving exterior syndrome and dispelling pathogenic wind. Relieving swelling and pain. The main treatment is as follows: cold, headache, nasal obstruction, nasosinusitis pain, supraorbital pain, carbuncle, swelling and sores.

Honeysuckle flower, nature and taste: sweet and cold. Meridian tropism: enter lung, heart and stomach meridians. The functions are as follows: clearing away heat and toxic material. Stir-baked into charcoal to cool blood and stop bleeding. The main treatment is as follows: wind-heat type of external contraction, acute fever, carbuncle, swelling, sore, toxic heat, bloody dysentery.

Elephantopus scaber, nature and taste: cool in nature and bitter in taste. The functions are as follows: clear heat and remove eye heat. The main treatment is as follows: rash with fever; dry beriberi; herpes zoster; heat-toxin of the skin; eye heat.

Ledebouriella root, nature and taste: pungent, sweet and warm. Meridian tropism: enter bladder, lung, liver and spleen meridians. The functions are as follows: relieving exterior syndrome, dispelling wind, eliminating dampness and relieving spasm. The main treatment is as follows: headache, blurred vision, arthralgia and tetanus caused by wind-cold or rheumatism.

Compared with the prior art, the embodiment of the invention has the beneficial effects that:

the plaster provided by the embodiment of the invention is added with tourmaline, fullerene and herbal essence containing a plurality of traditional Chinese medicine components, has no toxic or side effect, and has a plurality of efficacies of expelling cold and dampness, dredging channels and collaterals, resisting aging, refreshing brain, promoting blood circulation by removing blood stasis, nourishing and growing hair, removing freckles, beautifying and the like.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

This embodiment provides a plaster, the preparation method of which comprises the steps of:

(1) weighing 20g of tourmaline, 50g of fullerene and 100g of herbal essence for later use. Wherein the hundred-herb essence is a filtrate obtained by mixing and cooking the following components: 5g of herbal oil, 3g of bear gall, 15g of emu oil, 4g of murraya paniculata, 4g of magnolia flower, 4g of senecio cannabifolius, 4g of senecio scandens, 4g of angelica sinensis, 4g of pseudo-ginseng, 4g of fructus amomi, 4g of radix angelicae pubescentis, 1g of wild chrysanthemum flower, 1g of rhizoma cyperi, 1g of radix angelicae, 1g of honeysuckle, 1g of elephantopus scaber, 1g of radix sileris and 40g of dipotassium glycyrrhizinate.

(2) And grinding the tourmaline and the fullerene, and mixing with the herbal essence to obtain a mixture.

(3) And mixing the mixture and the hydrogel according to the mass ratio of 2:8 to prepare the plaster. The specific plaster making process can be the same as that of the existing plaster, and is not described herein again.

Example 2

(1) weighing 70g of tourmaline, 150g of fullerene and 200g of herbal essence for later use. Wherein the hundred-herb essence is a filtrate obtained by mixing and cooking the following components: 15g of herbal oil, 7g of bear gall, 25g of emu oil, 8g of murraya jasminorage, 8g of magnolia flower, 8g of senecio cannabifolius, 8g of senecio scandens, 8g of angelica sinensis, 8g of pseudo-ginseng, 8g of fructus amomi, 8g of radix angelicae pubescentis, 5g of wild chrysanthemum flower, 5g of rhizoma cyperi, 5g of radix angelicae, 5g of honeysuckle, 5g of elephantopus scaber, 5g of divaricate saposhnikovia root and 60g of dipotassium glycyrrhizinate.

(3) And mixing the mixture and the hydrogel according to a mass ratio of 4:6 to prepare the plaster. The specific plaster making process can be the same as that of the existing plaster, and is not described herein again.

Example 3

(1) weighing 40g of tourmaline, 80g of fullerene and 130g of herbal essence for later use. Wherein, 8g of herbal oil, 4g of bear gall, 18g of emu oil, 5g of murraya jasminorage, 5g of magnolia flower, 5g of senecio cannabifolius, 5g of groundsel, 5g of angelica, 5g of pseudo-ginseng, 5g of fructus amomi, 5g of radix angelicae pubescentis, 2g of wild chrysanthemum flower, 2g of rhizoma cyperi, 2g of radix angelicae, 2g of honeysuckle, 2g of elephantopus scaber, 2g of radix sileris and 45g of dipotassium glycyrrhizinate.

(3) And mixing the mixture and the hydrogel according to a mass ratio of 3:7 to prepare the plaster. The specific plaster making process can be the same as that of the existing plaster, and is not described herein again.

Example 4

(1) 60g of tourmaline, 120g of fullerene and 170g of herbal essence are weighed for standby. Wherein, 12g of herbal oil, 6g of bear gall, 22g of emu oil, 7g of murraya jasminorage, 7g of magnolia flower, 7g of senecio cannabifolius, 7g of senecio scandens, 7g of angelica, 7g of pseudo-ginseng, 7g of fructus amomi, 7g of radix angelicae pubescentis, 4g of wild chrysanthemum flower, 4g of rhizoma cyperi, 4g of radix angelicae, 4g of honeysuckle, 4g of elephantopus scaber, 4g of radix sileris and 55g of dipotassium glycyrrhizinate.

Example 5

(1) weighing 50g of tourmaline, 100g of fullerene and 150g of herbal essence for later use. Wherein, the traditional Chinese medicine composition comprises 10g of herbal oil, 5g of bear gall, 20g of emu oil, 6g of murraya jasminorage, 6g of magnolia flower, 6g of senecio cannabifolius, 6g of groundsel, 6g of angelica, 6g of pseudo-ginseng, 6g of fructus amomi, 6g of radix angelicae pubescentis, 3g of wild chrysanthemum flower, 3g of rhizoma cyperi, 3g of radix angelicae, 3g of honeysuckle, 3g of elephantopus scaber, 3g of radix sileris and 50g of dipotassium glycyrrhizinate.

(3) And mixing the mixture and hydrogel according to a mass ratio of 2.5:7.5 to prepare plaster. The specific plaster making process can be the same as that of the existing plaster, and is not described herein again.

Example 6

(1) weighing 50g of tourmaline, 100g of fullerene and 150g of herbal essence for later use. Wherein, the traditional Chinese medicine composition comprises 10g of herbal oil, 5g of bear gall, 20g of emu oil, 5g of murraya jasminorage, 7g of magnolia flower, 5g of senecio cannabifolius, 5g of groundsel, 6g of angelica, 6g of pseudo-ginseng, 5g of fructus amomi, 7g of radix angelicae pubescentis, 2g of wild chrysanthemum flower, 4g of rhizoma cyperi, 4g of radix angelicae, 2g of honeysuckle, 3g of elephantopus scaber, 3g of radix sileris and 52g of dipotassium glycyrrhizinate.

And (3) clinical trials:

firstly, the 60 patients with skin contusion are averagely divided into a test group I and a control group I, wherein the skin contusion patients are 20 years old with the smallest age, 75 years old with the largest age and 30 years old with the average age.

In addition, the plaster prepared in the example 6 is applied to the affected part of a patient with skin contusion once a day, 1g is applied once a day, 5 days are taken as a treatment course, and 2 treatment courses are totally applied; in the control group, commercially available ointment of BAIDUBAO is applied to the affected part of patients with skin contusion, once daily, 1g once, 5 days as a treatment course, and 2 treatment courses are total.

The evaluation criteria of the efficacy are: and (3) curing: the scab is healed without pain; the method has the following advantages: long scabbing time; and (4) invalidation: after 1 course of treatment, there was no scabbing or infection.

The statistical results of the treatment conditions of the test group I and the control group I are shown in the following Table 1.

TABLE 1

Treatment of conditions	Number of cases	Examples of invalidity	Working examples	Healing examples	Total effective rate (%)
						Control group one	30	5	18	7	83.3
Test set one	30	0	1	29	100

The test results in table 1 show that the plaster prepared by the embodiment of the invention has obvious treatment effect when being used for patients with skin contusion, and the total effective rate can reach 100% after 2 treatment courses; compared with the traditional plaster sold in the market, the plaster prepared by the embodiment of the invention has no toxic or side effect and has more effective treatment effect.

Typical cases are:

1: wu women, 30 years old, had a blunt object contusion on the left neck skin, and healed a scab 4 days after using the plaster provided in example 6 above.

2: wu women, 50 years old, had skin bruises on the left foot, and the scab healed up in 3 days after using the plaster provided in example 6 above.

And secondly, averagely dividing 60 hair thinning patients into a second test group and a second control group, wherein the minimum 50 years old, the maximum 75 years old and the average 60 years old of the hair thinning patients are selected.

In addition, the test group is that the plaster prepared in the embodiment 6 is coated on the head skin of a patient with sparse hair, 0.5g is applied once a day, 7 days are used as a treatment course, and 2 treatment courses are totally applied; the second control group is that the commercially available Zhangguang 101 plaster is applied to the head skin of patients with sparse hair, once a day, 0.5g is applied once, and a treatment course is 7 days, wherein 2 treatment courses are totally applied.

The evaluation criteria of the efficacy are: and (3) curing: the number of new hairs growing out is large (visual inspection); the method has the following advantages: the number of new hairs growing out is small (visual inspection); and (4) invalidation: there was substantially no new hair growth (visual inspection).

The statistical results of the treatment conditions of the test group two and the control group two are shown in the following table 2.

TABLE 2

Treatment of conditions	Number of cases	Examples of invalidity	Working examples	Healing examples	Total effective rate (%)
						Control group two	30	12	13	5	60
Test group two	30	0	1	29	100

The test results in table 2 show that the plaster prepared by the embodiment of the invention has obvious treatment effect when being used for patients with sparse hair, and the total effective rate can reach 100% after 2 treatment courses; compared with the traditional plaster sold in the market, the plaster prepared by the embodiment of the invention has no toxicity or side effect and has more effective treatment effect.

And thirdly, averagely dividing 60 patients with the stains into three groups of a test group and three groups of a control group, wherein the patients with the stains are 30 years old with the smallest age, 70 years old with the largest age and 40 years old with the average age.

In addition, the third test group is that the plaster prepared in the embodiment 6 is coated on the facial skin with color spots twice a day, 0.5g is used once, 15 days are taken as a treatment course, and 2 treatment courses are totally treated; in the third control group, commercially available self-air-drying scar nursing silica gel is coated on the pigmented facial skin twice a day, 0.5g is used once, 15 days are taken as a treatment course, and 2 treatment courses are total.

The evaluation criteria of the efficacy are: and (3) curing: no spots are observed by naked eyes; the method has the following advantages: observing the color spots by naked eyes for fading; and (4) invalidation: the stains were not changed by visual inspection.

The statistical results of the treatment conditions of the test group three and the control group three are shown in the following table 3.

TABLE 3

Treatment of conditions	Number of cases	Examples of invalidity	Working examples	Healing examples	Total effective rate (%)
						Control group III	30	20	5	0	16.7
Test group three	30	1	17	12	96.7

The test results in table 3 show that the plaster prepared by the embodiment of the invention has obvious treatment effect on the patients with color spots, and the total effective rate can reach 96.7% after 2 treatment courses; compared with the traditional plaster sold in the market, the plaster prepared by the embodiment of the invention has no toxicity or side effect and has more effective treatment effect.

Typical cases are:

1: plum women, 38 years old, with facial stain for 10 years, the facial stain was completely disappeared and the same color as the skin was restored by using the plaster provided in example 6 above for 20 days.

2: women, age 40, had an approximately 1 cm square spot on the front of the left ear, and after 5 years, 80% of the spot had disappeared after 20 days with the plaster provided in example 6 above, and after 15 days of continued use, all had returned to normal skin color.

In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.

Claims

1. A plaster is characterized by comprising the following components in parts by weight: 2-7 parts of tourmaline, 5-15 parts of fullerene and 10-20 parts of herbal essence; the herbal essence comprises the following components in parts by weight: 5-15 parts of herbal oil, 3-7 parts of bear gall, 15-25 parts of emu oil, 4-8 parts of murraya jasminorage, 4-8 parts of magnolia flower, 4-8 parts of hempleaf groundsel herb, 4-8 parts of senecio scandens, 4-8 parts of angelica sinensis, 4-8 parts of pseudo-ginseng, 4-8 parts of fructus amomi, 4-8 parts of radix angelicae pubescentis, 1-5 parts of wild chrysanthemum flower, 1-5 parts of rhizoma cyperi, 1-5 parts of radix angelicae, 1-5 parts of honeysuckle, 1-5 parts of elephantopus scaber, 1-5 parts of radix sileris and 40-60 parts of dipotassium glycyrrhizinate.

2. A plaster according to claim 1, which comprises the following components in parts by weight: 4-6 parts of tourmaline, 8-12 parts of fullerene and 13-17 parts of herbal essence.

3. A plaster according to claim 1, wherein the herbal extract comprises the following components in parts by weight: 8-12 parts of herbal oil, 4-6 parts of bear gall, 18-22 parts of emu oil, 5-7 parts of murraya jasminorage, 5-7 parts of magnolia flower, 5-7 parts of hempleaf groundsel herb, 5-7 parts of senecio scandens, 5-7 parts of angelica sinensis, 5-7 parts of pseudo-ginseng, 5-7 parts of fructus amomi, 5-7 parts of radix angelicae pubescentis, 2-4 parts of wild chrysanthemum flower, 2-4 parts of rhizoma cyperi, 2-4 parts of radix angelicae, 2-4 parts of honeysuckle, 2-4 parts of elephantopus scaber, 2-4 parts of radix sileris and 45-55 parts of dipotassium glycyrrhizinate.

4. A method for producing a plaster as claimed in any one of claims 1 to 3, comprising the steps of:

and mixing the mixture with hydrogel to prepare the plaster.

5. A method for preparing a plaster according to claim 4, wherein in the step (A), the mass ratio of the mixture to the hydrogel is (2-4) to (6-8).

6. A plaster prepared by the preparation method of claim 4 or 5.

7. Use of a plaster according to any one of claims 1 to 3 and 6 for the preparation of a medicament for the treatment of skin contusions.

8. Use of a plaster according to any one of claims 1 to 3 and 6 for the manufacture of a medicament for hair growth.

9. Use of a plaster according to any one of claims 1 to 3 and 6 for the preparation of a medicament for removing freckles.