CN110583681A - Chlorine-containing disinfectant and preparation method thereof - Google Patents
Chlorine-containing disinfectant and preparation method thereof Download PDFInfo
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- CN110583681A CN110583681A CN201910776052.0A CN201910776052A CN110583681A CN 110583681 A CN110583681 A CN 110583681A CN 201910776052 A CN201910776052 A CN 201910776052A CN 110583681 A CN110583681 A CN 110583681A
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- chlorine
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- parachlorometaxylenol
- pcmx
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Abstract
The invention discloses a chlorine-containing disinfectant and a preparation method thereof, wherein the chlorine-containing disinfectant comprises the following raw materials: 1.5-3% of parachlorometaxylenol PCMX, 2.8-6% of polyhexamethylene guanidine, 1-2.2% of surfactant, 1.2-2.8% of stabilizer, 2-4% of auxiliary agent and the balance of deionized water; the preparation method comprises the following steps: adding the auxiliary agent and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to prepare a mixed solution A; then adding a surfactant, a stabilizer and deionized water into the obtained mixed solution A, heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B; and finally, adding polyhexamethylene guanidine into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant. The disinfectant disclosed by the invention adopts nontoxic or low-toxicity raw materials, is safe, environment-friendly and environment-friendly to the environment and human bodies, and has the advantages of quick response, broad spectrum, high efficiency, low toxicity, no toxicity and the like.
Description
Technical Field
The invention relates to the technical field of disinfectant, in particular to chlorine-containing disinfectant and a preparation method thereof.
Background
Nosocomial infections refer to infections acquired within a medical facility. Including patients, medical staff, patients accompanying and visitors, all infections acquired in hospitals are nosocomial infections. In our country, however, this refers in particular to infections acquired by the patient during hospitalization. Hospital infection is a serious threat to the life and health of patients and also an important factor affecting the quality of medical treatment. The best way to deal with nosocomial infections is to take a good prescription for disinfection and sterilization, including medical equipment, ward environment, various articles, and the like. It has been demonstrated that the incidence of nosocomial infections can be greatly reduced by simply grasping the device for sterilization.
The disinfection solution in the current market generally contains chlorine components, and is generally divided into inorganic chlorine disinfection solution and organic chlorine disinfection solution, but the inorganic chlorine is unstable in property, is easily influenced by light, heat and humidity, loses effective components, and the organic chlorine is relatively stable, but is generally unstable after being dissolved in water. Therefore, in view of the above problems, an object of the present invention is to provide a chlorine-containing disinfectant that can stably exist in an aqueous solution, is stable in storage of the aqueous solution, has good stability and bactericidal effect, is safe, nontoxic or low-toxic, and can be widely popularized and applied, and a preparation method thereof.
Disclosure of Invention
In view of the above, the present invention aims to provide a disinfectant and a preparation method thereof, which can stably exist organic chlorine in an aqueous solution and achieve more efficient sterilization performance by improving components.
In order to achieve the purpose, the invention adopts the technical scheme that: a chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 1.5-3% of parachlorometaxylenol PCMX, 2.8-6% of polyhexamethylene guanidine, 1-2.2% of surfactant, 1.2-2.8% of stabilizer, 2-4% of assistant and the balance of deionized water.
The mass ratio of the parachlorometaxylenol PCMX to the polyhexamethylene guanidine is 1: (1-4), the reasonable compounding of the parachlorometaxylenol PCMX and the polyhexamethylene guanidine enhances the disinfection effect.
The surfactant is an amphoteric surfactant.
The stabilizing agent is polyethylene glycol and guar gum, wherein the mass ratio of the polyethylene glycol to the guar gum is (0.8-2.4): 1, the stabilizer not only enhances the stability of the organic chlorine in the aqueous solution, but also has the function of water retention and dispersion, so that hydrogen bonds are easily formed with water and the molecules are connected with each other.
The auxiliary agent is an ethanol solution with the volume fraction of 80%.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) adding the auxiliary agent and parachlorometaxylenol PCMX into a container according to the formula amount, and stirring and mixing uniformly at room temperature to prepare a mixed solution A;
(2) adding a surfactant, a stabilizer and deionized water in a formula amount into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
The invention adopts the ethanol solution with the volume fraction of 80% as the auxiliary agent, on one hand, the ethanol solution with the volume fraction of 80% is used for promoting the effective dissolution of the parachlorometaxylenol PCMX, on the other hand, the ethanol solution with the volume fraction of 80% has better sterilization effect, and the sterilization effect is further enhanced after the ethanol solution is mixed with the parachlorometaxylenol PCMX.
The invention has the beneficial effects that: the disinfectant disclosed by the invention adopts nontoxic or low-toxicity raw materials, is safe, environment-friendly and environment-friendly to the environment and human bodies, and has the advantages of quick response, broad spectrum, high efficiency, low toxicity, no toxicity and the like.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. These are all within the scope of the present invention (all of the starting components may be commercially available products well known to those skilled in the art).
Example 1
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 1.8% of parachlorometaxylenol PCMX, 4.2% of polyhexamethylene guanidine, 1.6% of amphoteric surfactant, 1.5% of polyethylene glycol, 0.8% of guar gum, 3% of ethanol solution with the volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the formula amount of amphoteric surfactant, polyethylene glycol, guar gum and deionized water into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Example 2
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 2% of parachlorometaxylenol PCMX, 4.8% of polyhexamethylene guanidine, 1.8% of amphoteric surfactant, 1.8% of polyethylene glycol, 0.8% of guar gum, 3.6% of ethanol solution with volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the formula amount of amphoteric surfactant, polyethylene glycol, guar gum and deionized water into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Example 3
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 2.4% of parachlorometaxylenol PCMX, 5.5% of polyhexamethylene guanidine, 2% of an amphoteric surfactant, 2% of polyethylene glycol, 0.6% of guar gum, 3.8% of an ethanol solution with the volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the formula amount of amphoteric surfactant, polyethylene glycol, guar gum and deionized water into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Comparative example 1
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 2% of parachlorometaxylenol PCMX, 4.8% of polyhexamethylene guanidine, 1.8% of amphoteric surfactant, 2.6% of polyethylene glycol, 3.6% of ethanol solution with the volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the formula amount of amphoteric surfactant, polyethylene glycol and deionized water into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Comparative example 2
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 2% of parachlorometaxylenol PCMX, 4.8% of polyhexamethylene guanidine, 1.8% of amphoteric surfactant, 2.6% of guar gum, 3.6% of ethanol solution with the volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the amphoteric surfactant, guar gum and deionized water in formula amount into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Comparative example 3
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 2% of parachlorometaxylenol PCMX, 4.8% of polyhexamethylene guanidine, 1.8% of amphoteric surfactant, 1.8% of polyethylene glycol, 0.4% of guar gum, 3.6% of ethanol solution with volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the formula amount of amphoteric surfactant, polyethylene glycol, guar gum and deionized water into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Comparative example 4
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 6.8% of parachlorometaxylenol PCMX, 1.8% of amphoteric surfactant, 1.8% of polyethylene glycol, 0.8% of guar gum, 3.6% of ethanol solution with volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, adding an ethanol solution with the volume fraction of 80% and parachlorometaxylenol PCMX into a container, and stirring and mixing uniformly at room temperature to obtain a mixed solution A;
(2) adding the amphoteric surfactant, the polyethylene glycol, the guar gum and the deionized water in the formula ratio into the mixed solution A obtained in the step (1), heating to 30-38 ℃, stirring and mixing uniformly to obtain mixed solution B, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Comparative example 5
A chlorine-containing disinfection solution comprises the following preparation raw materials in parts by mass: 6.8% of polyhexamethylene guanidine, 1.8% of amphoteric surfactant, 1.8% of polyethylene glycol, 0.8% of guar gum, 3.6% of ethanol solution with volume fraction of 80%, and the balance of deionized water.
The preparation method of the chlorine-containing disinfectant comprises the following steps:
(1) according to the formula amount, heating an ethanol solution with the volume fraction of 80%, an amphoteric surfactant, polyethylene glycol, guar gum and deionized water to 30-38 ℃, and uniformly stirring and mixing to obtain a mixed solution A;
(2) adding the polyhexamethylene guanidine with the formula amount into the mixed solution A, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
Experimental analysis and hospital actual environment sterilization analysis were performed on the sterilization effects of the sterilization liquids of examples 1 to 3 and comparative examples 1 to 5, and the results are shown in tables 1 and 2.
TABLE 1
TABLE 2
As can be seen from tables 1 and 2, compared with example 2, the disinfectant prepared by comparative examples 1-3 without adding guar gum or without adding polyethylene glycol or correspondingly increasing the comparative amount of polyethylene glycol and guar gum has no good effect as that of example 2, which indicates that the stabilizing agent polyethylene glycol and guar gum of the invention have synergistic effect and the prepared disinfectant has good stability and excellent disinfection effect according to a reasonable proportion; meanwhile, compared with the embodiment 2, the comparative examples 4 to 5 do not add polyhexamethylene guanidine or parachlorometaxylenol PCMX, and the prepared disinfectant has no good effect compared with the embodiment 2, so that the main compound sterilizer matrix polyhexamethylene guanidine and the parachlorometaxylenol PCMX have a synergistic effect, and the prepared disinfectant has good stability and excellent disinfection effect according to a reasonable proportion. Meanwhile, tables 1 and 2 also show that the disinfectant of the present invention can kill fungi, viruses, bacteria propagules and other microorganisms, and has the advantages of quick effect, broad spectrum and high efficiency, and good disinfection requirements are met.
The foregoing description of the invention has been presented for purposes of illustration and description. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (6)
1. The chlorine-containing disinfectant is characterized by comprising the following preparation raw materials in parts by mass: 1.5-3% of parachlorometaxylenol PCMX, 2.8-6% of polyhexamethylene guanidine, 1-2.2% of surfactant, 1.2-2.8% of stabilizer, 2-4% of assistant and the balance of deionized water.
2. The chlorine-containing disinfection solution as claimed in claim 1, wherein the mass ratio of the parachlorometaxylenol PCMX to the polyhexamethylene guanidine is 1: (1-4).
3. The chlorine-containing disinfection solution of claim 1, wherein the surfactant is an amphoteric surfactant.
4. The chlorine-containing disinfection solution as claimed in claim 1, wherein the stabilizing agent is polyethylene glycol and guar gum, and the mass ratio of polyethylene glycol to guar gum is (0.8-2.4): 1.
5. the chlorine-containing disinfection solution as claimed in claim 1, wherein the auxiliary agent is an 80 vol% ethanol solution.
6. The method for preparing chlorine-containing disinfection solution as claimed in any one of claims 1-5, comprising the following steps:
(1) adding the auxiliary agent and parachlorometaxylenol PCMX into a container according to the formula amount, and stirring and mixing uniformly at room temperature to prepare a mixed solution A;
(2) adding a surfactant, a stabilizer and deionized water in a formula amount into the mixed solution A obtained in the step (1), heating to 30-38 ℃, and uniformly stirring and mixing to obtain mixed solution B;
(3) adding the polyhexamethylene guanidine with the formula amount into the mixed solution B, stirring and mixing uniformly, cooling to room temperature, and filling to obtain the chlorine-containing disinfectant.
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| CN201910776052.0A CN110583681A (en) | 2019-08-22 | 2019-08-22 | Chlorine-containing disinfectant and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111607469A (en) * | 2020-07-08 | 2020-09-01 | 青岛拜士特新材料有限公司 | Instant antibacterial masterbatch and preparation method thereof |
| CN111690469A (en) * | 2020-07-08 | 2020-09-22 | 青岛拜士特新材料有限公司 | Degerming washing powder containing zinc pyrithione antibacterial agent and preparation method thereof |
| CN111733027A (en) * | 2020-07-08 | 2020-10-02 | 青岛拜士特新材料有限公司 | Instant washing antibacterial master batch and preparation method thereof |
| CN111733021A (en) * | 2020-07-08 | 2020-10-02 | 青岛拜士特新材料有限公司 | Sterilizing washing powder containing PCMX and preparation method thereof |
-
2019
- 2019-08-22 CN CN201910776052.0A patent/CN110583681A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111607469A (en) * | 2020-07-08 | 2020-09-01 | 青岛拜士特新材料有限公司 | Instant antibacterial masterbatch and preparation method thereof |
| CN111690469A (en) * | 2020-07-08 | 2020-09-22 | 青岛拜士特新材料有限公司 | Degerming washing powder containing zinc pyrithione antibacterial agent and preparation method thereof |
| CN111733027A (en) * | 2020-07-08 | 2020-10-02 | 青岛拜士特新材料有限公司 | Instant washing antibacterial master batch and preparation method thereof |
| CN111733021A (en) * | 2020-07-08 | 2020-10-02 | 青岛拜士特新材料有限公司 | Sterilizing washing powder containing PCMX and preparation method thereof |
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Application publication date: 20191220 |