CN110574830A - Regulator for relieving weaning stress response of mammals and preparation method and application thereof - Google Patents
Regulator for relieving weaning stress response of mammals and preparation method and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3544—Organic compounds containing hetero rings
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention discloses a regulator for relieving weaning stress response of mammals, which comprises the following components in percentage by mass: 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of ethoxyquinoline powder with the mass percentage of 60 percent, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of soybean meal, wherein the sum of the mass percentages of the components is 100 percent. The invention also discloses a preparation method of the regulator, which is obtained by weighing and mixing the components according to the mass percentage, and the regulator can be used as an additive to be added into basic feed of mammals in weaning period, and can relieve the stress reactions of diarrhea, slow growth and the like caused by the mammals in weaning period.
Description
Technical Field
The invention belongs to the technical field of mammal regulators, and particularly relates to a regulator for relieving weaning stress of mammals, and a preparation method and application of the regulator for relieving weaning stress of mammals.
Background
Early weaning is an effective way to maximize the production of the entire herd and is increasingly gaining attention in modern intensive meat production systems. In recent years, with the rapid development of large-scale livestock husbandry, more and more mammalian farms such as pigs, sheep, cattle and the like start to apply an early weaning technology, the application of the early weaning technology promotes the production of animal breeding and can expand the production benefit, but the early weaning technology also causes stress syndromes of weaned mammals such as piglets, lambs, calves and the like to be high, the mammals can be accompanied with strong psychological, environmental and nutritional stress reactions during weaning, for example, temporary endocrine reactions occur, gastrointestinal tract energy and protein metabolism can be changed, the feed intake and the growth speed can be influenced, and the gastric digestion function can be reduced; the immune system may be affected, with significant effects causing diarrhea, malnutrition and growth retardation.
Chitosan oligosaccharide is a rich natural resource, and has attracted attention because of its various properties such as good biocompatibility and biodegradability. In recent years, with the development of research on chitosan oligosaccharide, it has been found that chitosan oligosaccharide has more and more extensive applications in various fields such as food, chemical industry, biomedicine, and the like, and particularly in the biomedicine field, it has been found that chitosan oligosaccharide has properties such as oxidation resistance, antibacterial property, and the like. The chitosan oligosaccharide with carboxymethyl groups is applied to the stress reaction of mammals in weaning period by utilizing the antioxidant and antibacterial properties of the chitosan oligosaccharide, wherein the carboxymethyl groups can improve the antioxidant and antibacterial properties of the chitosan oligosaccharide to overcome the stress reaction of the mammals in weaning period, so that the chitosan oligosaccharide is used as a natural and nontoxic animal stress reaction regulator.
Disclosure of Invention
The first purpose of the present invention is to provide a regulator for alleviating the weaning stress in mammals, which achieves the purpose of alleviating the weaning stress in mammals.
It is a second object of the present invention to provide a method for preparing a modulator for alleviating weaning stress in a mammal.
It is a third object of the present invention to provide a method of using a modulator for alleviating weaning stress in a mammal.
The first technical scheme adopted by the invention is that the regulator for relieving the weaning stress response of the mammals consists of the following components in percentage by mass: 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of antioxidant, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of bean pulp, wherein the sum of the mass percentages of the components is 100 percent.
the first technical solution of the present invention is also characterized in that,
The antioxidant is 60 percent of ethoxyquin powder in percentage by mass.
The mildew preventive is specifically 500 mildew.
The second technical scheme adopted by the invention is that the preparation method of the regulator for relieving the weaning stress response of the mammals is implemented according to the following steps:
Step 1, weighing 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of antioxidant, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of soybean meal according to the mass percentage, wherein the sum of the mass percentages of the components is 100 percent;
and 2, mixing the carboxymethyl chitosan oligosaccharide weighed in the step 1, silicon dioxide and bean pulp, adding the antioxidant and the mildew preventive weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
the second technical solution of the present invention is also characterized in that,
and (2) crushing the carboxymethyl chitosan oligosaccharide and the bean pulp in the step (1) by a crusher, and then sieving the crushed carboxymethyl chitosan oligosaccharide and the bean pulp by a sieve with the aperture of 80-100 meshes to obtain the carboxymethyl chitosan oligosaccharide and the bean pulp with the particle size of not more than 100 meshes.
the third technical scheme adopted by the invention is that the regulator for relieving the weaning stress response of the mammals is used as an additive to feed weaned piglets.
The first technical solution of the present invention has at least the following advantages,
1) The average daily gain of the mammals in the weaning period can be obviously improved, the feed-weight ratio is reduced, the growth performance of the mammals in the weaning period is improved, and the diarrhea of the mammals in the weaning period is effectively prevented and treated;
2) the components are safe and have no harmful residue, and meanwhile, the addition of antibiotics in the feed of mammals in the weaning period is reduced, so that the harm caused by eating the mammals with the antibiotic residues by human is avoided;
3) The carboxymethyl chitosan oligosaccharide can enter an organism through absorption of epithelial cells of the mammals in the weaning period, so that the antibacterial and antioxidant capacity is improved, the anti-stress capacity is enhanced, and the growth and development are promoted;
4) The formula is reasonable, the components have synergistic effect, the dosage is small, the preparation method is simple, the condition controllability is good, and the application prospect is good.
the second technical scheme of the invention has the beneficial effects that: the carboxymethyl chitosan oligosaccharide and the silicon dioxide are solid powder with low content, and are mixed with the soybean meal to ensure uniform mixing, and then the antioxidant, namely ethoxyquinoline powder and the mildew preventive with the mass percentage of 60 percent are added, so that the components are uniformly distributed in the stress regulator; in order to facilitate the feeding and intestinal absorption of the regulator for the weaned mammals, the carboxymethyl chitosan oligosaccharide and the soybean meal are crushed and sieved so as to increase the contact area between digestive enzymes in the weaned mammals and the regulator in the feed and improve the absorption rate; the preparation method is simple, has good controllability of conditions, and has good stability and full cooperation of the components.
The third technical scheme of the invention has the beneficial effects that: the regulator is added into feed for piglets and lambs in the weaning period, so that the growth performance of the piglets and the lambs can be improved, the diarrhea incidence rate is reduced, and the weaning stress response of the piglets and the lambs is effectively relieved.
drawings
FIG. 1 is a control test plot of diarrhea index for weaned piglets after ingestion of a basal diet supplemented with a regulator of the present invention;
Fig. 2 is a control test plot of the diarrhea rate of weaned piglets after ingestion of a basal diet supplemented with the present regulator.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
the regulator for relieving the weaning stress response of the mammals comprises the following components in percentage by mass: 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of antioxidant, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of bean pulp, wherein the sum of the mass percentages of the components is 100 percent, the antioxidant is ethoxyquinoline powder with the mass percentage of 60 percent, and the mildew preventive is specifically 500 mildew.
The preparation method of the regulator for relieving the weaning stress response of the mammals, disclosed by the invention, is implemented according to the following steps:
Step 1, weighing 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of ethoxyquinoline powder with the mass percent of 60 percent, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of bean pulp according to the mass percent, wherein the sum of the mass percent of the components is 100 percent; wherein, the carboxymethyl chitosan oligosaccharide and the bean pulp are crushed by a crusher and then pass through a screen with the aperture of 80 meshes to 100 meshes to obtain the carboxymethyl chitosan oligosaccharide and the bean pulp with the particle size not more than 100 meshes;
And 2, mixing the carboxymethyl chitosan oligosaccharide, the silicon dioxide and the bean pulp which are weighed in the step 1, adding 60 mass percent of ethoxyquinoline powder and a mildew preventive (500 mildew) which are weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
The application method of the regulator for relieving the weaning stress response of the mammals comprises the steps of adding the regulator for relieving the weaning stress response of the mammals into basic daily ration of piglet feed according to the mass percent of 0.175-0.19%; the growth performance of the piglets can be improved, the diarrhea incidence rate is reduced, and the weaning stress reaction of the piglets is effectively relieved; the stress regulator is added into the basal ration of the piglet feed according to the weight percentage of 0.175-0.19 percent, so that the cost and the effect of the piglet feed can reach the optimal balance.
The function of each raw material in the regulator is as follows: the ethoxyquin is an antioxidant, can prevent vitamin A, D, E and other natural pigments from oxidative discoloration caused by fat oxygen, and has certain mildew-proof and fresh-keeping effects; propionic acid is mainly used as a food mildew preventive and a mildew preventive, and has a weak function of inhibiting the growth of fungi in vivo and in vitro; the soybean meal is a byproduct obtained after soybean oil is extracted from soybeans, is easy to absorb and utilize, improves the utilization rate of feed, can inhibit the growth and the propagation of harmful flora, keeps the stable micro-ecological environment in intestinal tracts and avoids intestinal tract diseases; the carboxymethyl chitosan oligosaccharide is a carboxymethylation modified product of the chitosan oligosaccharide, has the characteristics of low molecular weight and good water solubility, and can be directly absorbed by epithelial cells of animal intestinal tracts. In addition, the carboxymethyl chitosan oligosaccharide modified by chemical bond positions has better antibacterial and antioxidant activities than chitosan oligosaccharide, can effectively inhibit the growth of harmful flora, protect cells from being damaged by oxidative stress, and improve the growth performance of weaned pigs.
the ethoxyquin and the propionic acid can synergistically improve the mildew resistance and the oxidation resistance of the stress regulator, the soybean meal and the carboxymethyl chitosan oligosaccharide can synergistically improve the absorption and utilization of feed, inhibit the growth of harmful flora, reduce the diarrhea rate of weaned piglets and improve the growth performance. The components are reasonably proportioned and fed to weaned pigs, so that the characteristics of safety, harmlessness, antibiosis, antioxidation, digestion and absorption conditioning and the like of the weaned pigs can be fully exerted, growth retardation, diarrhea and the like caused by weaned stress of the piglets are prevented and treated, and the weaned stress of the piglets is relieved.
The sources of the respective raw materials: the carboxymethyl chitosan oligosaccharide is self-made in a laboratory and is obtained by carboxymethylation modification of the chitosan oligosaccharide, the deacetylation degree is more than or equal to 85 percent, and the substitution degree is more than or equal to 110 percent; chitosan oligosaccharide is purchased from Dalian Meiren biotechnology, Inc., and has the following characteristics: yellowish to tawny powder, the deacetylation degree is more than or equal to 90 percent, and the molecular weight is less than or equal to 2000 Da; 60 percent of ethoxyquinoline powder with the ethoxyquinoline content being more than or equal to 60 percent by mass, which is purchased from Jiangsu Litian science and technology GmbH; the mildew preventive is 500 mildew, propionic acid is more than or equal to 60 percent, and water is less than or equal to 10 percent, and is purchased from Chongqing Huaruilong biotechnology limited company; soybean meal purchased from the grongchang Hengfeng grain Mingsheng; wherein, the ethoxy quinoline powder with the mass percentage of 60 percent comprises the following raw materials: ethoxyquinoline with silicon dioxide; the mildew preventive comprises the following raw materials: propionic acid, sodium propionate and silica.
Example 1
A preparation method of a regulator for relieving weaning stress of mammals,
Step 1, weighing 2.86% of carboxymethyl chitosan oligosaccharide, 11.43% of ethoxyquinoline powder with the mass percentage of 60%, 22.86% of mildew preventive (500 mildew), 5.71% of silicon dioxide and 57.14% of bean pulp according to the mass percentage, wherein the sum of the mass percentages of the components is 100%; wherein, the carboxymethyl chitosan oligosaccharide and the bean pulp are crushed by a crusher and then pass through a sieve with 80 meshes of aperture;
and 2, mixing the carboxymethyl chitosan oligosaccharide, the silicon dioxide and the bean pulp which are weighed in the step 1, adding 60 mass percent of ethoxyquinoline powder and a mildew preventive (500 mildew) which are weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
A method of using a modulator for alleviating weaning stress in a mammal,
The stress regulator is added into the basal ration of the piglet feed according to the weight percentage of 0.175 percent.
Example 2
a preparation method of a regulator for relieving weaning stress of mammals,
Step 1, weighing 5.56 percent of carboxymethyl chitosan oligosaccharide, 11.11 percent of ethoxyquinoline powder with the mass percent of 60 percent, 22.22 percent of mildew preventive (500 mildew), 5.56 percent of silicon dioxide and 55.55 percent of bean pulp according to the mass percent, wherein the sum of the mass percent of the above components is 100 percent; wherein, the carboxymethyl chitosan oligosaccharide and the bean pulp are crushed by a crusher and then pass through a sieve with the aperture of 90 meshes;
And 2, mixing the carboxymethyl chitosan oligosaccharide, the silicon dioxide and the bean pulp which are weighed in the step 1, adding 60 mass percent of ethoxyquinoline powder and a mildew preventive (500 mildew) which are weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
A method of using a modulator for alleviating weaning stress in a mammal,
The stress regulator is added into the basal ration of the piglet feed according to the weight percentage of 0.18 percent.
Example 3
a preparation method of a regulator for relieving weaning stress of mammals,
Step 1, weighing 10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53 percent of ethoxyquinoline powder with the mass percent of 60 percent, 21.05 percent of mildew preventive (500 mildew), 5.26 percent of silicon dioxide and 52.63 percent of soybean meal according to the mass percent, wherein the sum of the mass percent of the above components is 100 percent; wherein, the carboxymethyl chitosan oligosaccharide and the bean pulp are crushed by a crusher and then pass through a screen with the aperture of 100 meshes;
And 2, mixing the carboxymethyl chitosan oligosaccharide, the silicon dioxide and the bean pulp which are weighed in the step 1, adding 60 mass percent of ethoxyquinoline powder and a mildew preventive (500 mildew) which are weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
a method of using a modulator for alleviating weaning stress in a mammal,
the stress regulator is added into the basal ration of the piglet feed according to the weight percentage of 0.19 percent.
The regulator for relieving the weaning stress response of the mammals is applied to the test of weaned piglets,
the regulator prepared in the embodiment 1-3 is added into basic daily ration according to the mass percent of 0.175%, 0.18% and 0.19% of the basic daily ration respectively, the experiment adopts single factor design, the 21-day-old weaned pigs are selected, 96 pigs have the same birth times, the daily ration components of sows are the same, the healthy Rongchang piglets with the same genetic background are randomly divided into 4 treatment groups, each group has 3 repetitions, each repetition has 8 repetitions (half of a male and a female), and the weight difference of the piglets in each group is not obvious. One of the 4 groups of piglets served as a control group and fed with the basic ration, and the other 3 groups served as test groups and fed with the basic ration added with the regulator prepared in the examples 1-3, wherein the addition amounts of the regulator in the examples 1-3 are 0.175%, 0.18% and 0.19%, respectively, the test period comprises a transition period of 3 days and a test period of 14 days, and the average daily gain, the average daily feed intake, the feed-weight ratio and the diarrhea rate are calculated after the test is finished.
the test data were collated by Excel 2013, growth performance was analyzed by single factor analysis of variance (ANOVA) using SPSS19.0 statistical software, multiple comparisons were performed by LSD method and regression statistical analysis was performed. Diarrhea indices were analyzed for two-factor interaction anova for major effects (time and diet) and for interaction between the two. Diarrhea rates were only analyzed by one-way analysis of variance (ANOVA) and multiple comparisons were made using the LSD method. The experimental data were analyzed for significance of differences, with results in mean ± standard deviation And (4) showing.
the basal ration components are shown in table 1,
TABLE 1 basic diet Components
The nutritional components of the premix are shown in table 2,
TABLE 2 nutritional Components of the premix
The premix is provided for each kilogram of feed: 6.00g of lysine, 1.75g of methionine, 3.50g of threonine, 6200IU of vitamin A, 31000 IU of vitamin D, 77.47mg of copper, 68.72mg of zinc, 71.22g of crude protein, 17.49g of crude fiber, 49.98g of crude ash, 7.50g of calcium, 1.75g of total phosphorus and 9.37g of sodium chloride; crude protein, calcium, total phosphorus, etc. were analyzed and the rest was calculated as NRC (2012).
the compositions of the modulators of the different test groups are shown in table 3,
TABLE 3 different test groups of conditioner compositions
The effect of modulators that alleviate the weaning stress in mammals on the growth of weaned piglets is shown in table 4, where the results are expressed as mean ± standard deviation and n-3.
TABLE 4 growth of weaned piglets
Note: the number of the star or the # in the table is a special symbol, the data in the same row are marked with no special symbol or the same special symbol to indicate that the difference is not significant (P >0.05), and different special symbols to indicate that the difference is significant (P < 0.05).
As can be seen from table 4, the weight difference of the weaned piglets in each test group is not significant at the beginning of the test, and the weight of the weaned piglets in the test group is significantly higher than that in the control group (P <0.05) at the end of the test; the average daily gain of each test group is obviously improved compared with that of a control group (P <0.05) in the whole test period, namely in a staged or full test period; the feed weight of each test group is obviously reduced compared with that of a control group (P <0.05) in the whole test period, the tail weight of the weaned pig shows obvious secondary curve increasing effect (P <0.05), the average daily gain of the weaned pig shows obvious linear and secondary curve increasing effect (P <0.05) along with the increase of the addition amount of the carboxymethyl chitooligosaccharide, and the feed weight ratio of the weaned pig shows obvious linear and secondary curve reducing effect (P < 0.05). The growth performance of the weaned piglets can be improved by feeding the daily ration added with the animal stress regulator.
The effect of modulators of alleviation of the weaning stress on the diarrhea index of weaned piglets is shown in fig. 1, where the results are expressed as mean ± standard deviation, n is 3, and in the figure, # and # are special symbols, and the data points on the same sample day are marked with different special symbols to indicate a significant difference between groups (P < 0.05). The overlapping data points are labeled identically with no duplicate designation.
as shown in FIG. 1, piglets developed more severe diarrhea throughout the test period around day 4-8. The diarrhea index of the weaned piglets in the test group 2 is significantly lower than that of the control group (P <0.05) at the 3 rd day of the test, the diarrhea index of the weaned piglets in the test groups 1 and 2 is significantly lower than that of the control group (P <0.05) at the 4 th day of the test, the diarrhea index of the weaned piglets in the test groups 1 and 3 is significantly lower than that of the control group (P <0.05) at the 5 th day of the test, and the diarrhea index of the weaned piglets in the test group 3 is significantly lower than that of the control group (P <0.05) at the 12. Both diet and time had a significant effect on the diarrhea index of weaned piglets (P <0.05) throughout the test period, but both had no significant interactive effect on the diarrhea index of weaned piglets (P > 0.05).
The effect of modulators of alleviation of the weaning stress on the diarrhea rate of weaned piglets is shown in fig. 2, wherein the results are expressed as mean ± standard deviation, n is 3, and x and # are special symbols in the figure, the data are marked with no special symbol or the same special symbol indicates no significant difference (P >0.05), and different special symbols indicate significant difference (P < 0.05).
As can be seen from fig. 2, the diarrhea rates of the control group, the test group 1, the test group 2 and the test group 3 after the addition of different amounts of carboxymethyl chitooligosaccharide were 22.02%, 11.31%, 12.20% and 10.71%, respectively, and the diarrhea rate of the weaned piglets after the addition of the regulator was significantly reduced (P < 0.05). The results show that the diarrhea of the weaned piglets can be relieved by feeding the daily ration added with the regulator.
in conclusion, the regulator for relieving the weaning stress response of the mammals is added into the feed, so that the growth performance of the weaned piglets can be improved, the diarrhea rate of the piglets is reduced, the growth of the piglets is promoted, and the antioxidant stress capability is enhanced, thereby relieving the weaning stress syndrome of the piglets. The preparation method of the regulator is simple, and the preparation conditions are good in controllability. The regulator for relieving the weaning stress response of the mammals is added into the piglet feed to effectively relieve the weaning stress of the piglets.
Claims (6)
1. The regulator for relieving the weaning stress response of the mammals is characterized by comprising the following components in percentage by mass: 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of antioxidant, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of bean pulp, wherein the sum of the mass percentages of the components is 100 percent.
2. the regulator for alleviating weaning stress in a mammal according to claim 1, wherein said antioxidant is ethoxyquinoline powder in an amount of 60% by mass.
3. a regulator for alleviating weaning stress in a mammal according to claim 1 or 2, wherein said antifungal agent is specifically 500 mildew.
4. The method of preparing a regulator for alleviating weaning stress in a mammal according to claim 1, comprising the steps of:
Step 1, weighing 2.86-10.53 percent of carboxymethyl chitosan oligosaccharide, 10.53-11.43 percent of antioxidant, 21.05-22.86 percent of mildew preventive, 5.26-5.71 percent of silicon dioxide and 52.63-57.14 percent of soybean meal according to the mass percentage, wherein the sum of the mass percentages of the components is 100 percent;
And 2, mixing the carboxymethyl chitosan oligosaccharide weighed in the step 1, silicon dioxide and bean pulp, adding the antioxidant and the mildew preventive weighed in the step 1, and mixing again to obtain the regulator for relieving the weaning stress reaction of the mammals.
5. the method for preparing a regulator for alleviating weaning stress in mammals according to claim 4, wherein the carboxymethyl chitooligosaccharide and the soybean meal in step 1 are pulverized by a pulverizer, and then passed through a sieve having a pore size of 80-100 mesh to obtain carboxymethyl chitooligosaccharide and soybean meal having a particle size of not more than 100 mesh.
6. Use of the modulator of alleviating weaning stress in a mammal of claim 1 as an additive to feed weaned piglets.
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