CN110559211B - Antibacterial and anticarious composition, and preparation method and application thereof - Google Patents

Antibacterial and anticarious composition, and preparation method and application thereof Download PDF

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CN110559211B
CN110559211B CN201910959177.7A CN201910959177A CN110559211B CN 110559211 B CN110559211 B CN 110559211B CN 201910959177 A CN201910959177 A CN 201910959177A CN 110559211 B CN110559211 B CN 110559211B
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polyphosphate
mixture
toothpaste
composition
anticarious
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CN110559211A (en
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尹利娟
张环
邓全富
唐伟月
陆瑜
邓嵘
邱琳
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Chongqing Dencare Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Abstract

The invention belongs to the field of daily chemicals, relates to a composition for an oral product, and a preparation method and application thereof, and particularly relates to a bacteriostatic and anticarious composition, and a preparation method and application thereof. The bacteriostatic anticarious composition consists of polydopamine particles and polyphosphate. The two substances have synergistic effect on inhibiting common bacteria in oral cavity environment, and the antibacterial and anticarious composition consisting of polydopamine particles and polyphosphate has good effects on preventing periodontal diseases and caries. The antibacterial and anticarious composition can be applied to the development and production of toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.

Description

Antibacterial and anticarious composition, and preparation method and application thereof
Technical Field
The invention belongs to the field of daily chemicals, relates to a composition for an oral product, and a preparation method and application thereof, and particularly relates to a bacteriostatic and anticarious composition, and a preparation method and application thereof.
Background
Dopamine (4- (2-ethylamino) benzene-1, 2-diol) is a typical catechol-based derivative that self-polymerizes under alkaline conditions to form polydopamine particles. The poly-dopamine particle has a large number of active groups such as phenolic hydroxyl groups, amino groups and the like on the surface and in the structure, so that the poly-dopamine particle has excellent surface activity. The polydopamine particles have rich reducing functional groups such as catechol and imine, have certain antioxidant activity, and can effectively inhibit periodontal diseases (including oxidative stress periodontal diseases) caused by excessive active oxygen. The polydopamine particles also have antibacterial properties, and experimental tests show that the polydopamine particles have an inhibitory effect on both gram-positive staphylococcus aureus and gram-negative escherichia coli. In addition, the polydopamine particles have good adhesion and biocompatibility, and the preparation process is simple and the preparation cost is low. Currently, polydopamine particles have been used in the production of oral cleaning products.
Chinese patent CN106176378A (a preparation method of toothpaste and mouthwash for preventing caries and repairing dental caries) discloses a dopamine-containing toothpaste, wherein when the toothpaste is used for cleaning oral cavity, dopamine is oxidized and self-polymerized to form polydopamine particles which are adhered to the surface of dentin, thereby realizing remineralization of the dentin, forming a firm and compact protective layer, and effectively preventing caries and repairing dental caries. However, the prior art solutions have the following drawbacks: (1) polydopamine particles alone have limited ability to combat bacteria commonly found in the oral environment (e.g., streptococcus mutans and porphyromonas gingivalis); (2) the poly-dopamine particles are easy to aggregate, so that the poly-dopamine particles cannot be uniformly attached to the surfaces of teeth, the application of the poly-dopamine particles in the oral environment is hindered, and the antibacterial and anticarious effects of the poly-dopamine particles are limited.
Disclosure of Invention
The invention aims to provide a bacteriostatic and anticarious composition which can effectively inhibit common bacteria in the oral environment and has the effect of preventing caries.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a composition with antibacterial and anticarious effects comprises polydopamine granule and polyphosphate.
By adopting the technical scheme, the technical principle and the beneficial effects are as follows:
the polydopamine particles have antioxidant and antibacterial effects, and can effectively inhibit periodontal diseases; the polyphosphate can influence and inhibit the generation and development of dental caries by changing the physicochemical and biological properties of teeth, saliva and dental plaque. Based on the properties of the two substances, the inventors added both substances to the oral cleaning article to achieve their respective effects. The inventor unexpectedly found that the two substances have a synergistic effect in inhibiting bacteria which are common in the oral environment. The inventor carries out a large number of bacteriostatic tests and verifies that the combined use of the polydopamine particles and the polyphosphate has a synergistic phenomenon. Compared with the single use of polydopamine particles and the single use of polyphosphate, the bacteriostatic effect of the bacteriostatic caries-preventing composition (namely the combined use of polydopamine particles and polyphosphate) is obviously improved. The inventor analyzes that the mechanism of the synergy of the two substances is as follows: the polydopamine particles have cell adhesion, can be attached to biomolecules and coated on the surfaces of bacteria, so that the permeation and absorption of vital substances (such as nutrients and other chemical substances) of the bacteria are hindered, and the discharge of metabolic waste is blocked, so that the growth of the bacteria is inhibited; the polyphosphate can change the biological characteristics of the surface of bacteria, so that poly-dopamine particles can be easily accumulated and covered on the surface of the bacteria, and the exchange of substances between the bacteria and the external environment is more strongly inhibited.
In summary, the antibacterial and anticarious composition consisting of the polydopamine particles and the polyphosphate has the beneficial effects that:
(1) the polydopamine particles and the polyphosphate are combined for the first time, and the composition formed by the polydopamine particles and the polyphosphate has the functions of inhibiting bacteria and preventing caries. In addition, the two substances have a synergistic effect on the effect of inhibiting common bacteria in the oral environment. Because of the synergistic effect of the two on the bacteriostasis, the effects of preventing periodontal disease and caries of the bacteriostasis and caries-prevention composition are enhanced.
(2) The polyphosphate has the effect of inhibiting the occurrence and the development of caries, can replace fluoride in the prior art to be added into oral products, and avoids toxic side effects caused by excessive fluorine intake. The polyphosphate can effectively change the physicochemical and biological properties of teeth, saliva and dental plaque, thereby inhibiting the occurrence and development of dental caries.
(3) The polydopamine particles have double effects of oxidation resistance and antibiosis, and can cover the surfaces of teeth, thereby having a certain effect of protecting the teeth and preventing dental caries. In addition, polydopamine particles coat the surface of a living body, so that the source of substances required by the life of bacteria is blocked, and the purpose of bacteriostasis is achieved. In addition, the polydopamine particle surface has rich reducing functional groups such as catechol and imine, and can effectively inhibit oral diseases (including oxidative stress periodontal diseases) caused by excessive active oxygen.
(4) The polydopamine particles and the polyphosphate have the advantages of good biocompatibility, simple preparation method and low cost.
Further, the weight percentage of the polydopamine particles is 1-30%, and the balance is polyphosphate.
By adopting the technical scheme, the antibacterial and anticarious composition can obtain better antibacterial effect, thereby preventing the occurrence of caries.
Further, the polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, calcium polyphosphate, strontium polyphosphate and zinc polyphosphate.
By adopting the technical scheme, different types of polyphosphates can be selected according to actual needs. For example, strontium polyphosphate is selected to cooperate with polydopamine particles, and in addition to the synergistic bacteriostatic effect of the two, strontium ions also have the effect of preventing tooth sensitivity.
Further, an application of the antibacterial and anticarious composition in toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.
By adopting the technical scheme, the antibacterial and anticarious composition consisting of the polydopamine particles and the polyphosphate is applied to toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum, and the two substances (the polydopamine particles and the polyphosphate) are synergistic in the using process, so that the inhibition of oral bacteria and the prevention and treatment of caries can be realized. The antibacterial and anticarious composition has multiple protection effects on the oral cavity, can improve some pathological symptoms of the oral cavity, slow down periodontal disease and gingivitis, inhibit the breeding of streptococcus mutans, and help users to prevent and treat caries.
The toothpaste body of the liquid toothpaste is transparent colloidal liquid, is amorphous liquid particles, is developed on the basis of the toothpaste, and can quickly go deep into the slit between the teeth to cover the whole teeth.
Further, the raw materials of the toothpaste comprise an abrasive, a thickening agent, a humectant, a flavoring agent, a surfactant, essence, water and a bacteriostatic and anticarious composition; the antibacterial and anticarious composition consists of polydopamine particles and polyphosphate.
By adopting the technical scheme, the toothpaste is the most common oral cavity cleaning product with the highest use frequency, and the antibacterial and anticarious composition is added into the toothpaste, so that the use frequency of the antibacterial and anticarious composition can be increased, and better effects of inhibiting oral bacteria and preventing caries can be obtained.
Further, the humectant comprises polyethylene glycol and the rest humectant, wherein the rest humectant is one or a mixture of more than one of glycerol, sorbitol and propylene glycol.
By adopting the technical scheme, the polyethylene glycol can prevent polydopamine particles from aggregating, so that the biological efficacy (bacteriostasis and caries prevention effect) of the polydopamine particles is increased. The inventor finds that the polydopamine particles are easy to aggregate in the preparation process of the toothpaste, and particularly when the antibacterial and anticarious composition is directly added into a toothpaste system, the polydopamine particles and other water materials in the toothpaste system have compatibility, so that the toothpaste can agglomerate and dry, and the stability of the toothpaste is poor. In an attempt to solve the above problems, the inventors have found that the addition of polyethylene glycol to toothpaste can functionalize the surface of polydopamine particles, greatly enhance the stability and functionality of polydopamine particles, and reduce the aggregation of polydopamine particles. And one or more of glycerin, sorbitol and propylene glycol are compounded, so that the toothpaste body system containing the toothpaste is stable, and the problems of poor stability and difficult storage of the toothpaste are solved.
Further, the thickening agent is one or a mixture of more than one of hydroxyethyl cellulose, xanthan gum, carrageenan, carbomer and hydroxymethyl cellulose.
By adopting the technical scheme, the thickening agent is a commonly used substance in the prior art, and has the advantages of good safety and stability, low price and easy acquisition.
Further, the surfactant is one or a mixture of more than one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium sulfur sulfonate and cocamidopropyl betaine.
By adopting the technical scheme, the surfactant is a commonly used substance in the prior art, and has the advantages of good safety and stability, low price and easy acquisition.
Further, the toothpaste comprises the following raw materials in percentage by weight: 0.025-0.5% of polydopamine particles, 1.2-2% of polyphosphate, 5-70% of humectant, 0-60% of abrasive, 0.3-10% of thickener, 0.1-20% of surfactant, 0.1-2% of flavoring agent, 0.1-5% of essence, 0-0.25% of preservative and the balance of water.
By adopting the technical scheme, the toothpaste prepared according to the components and the content has better effects of resisting bacteria, preventing decayed teeth and relieving periodontal disease and gingivitis.
Further, the toothpaste is prepared by the following method:
(1) dissolving polydopamine particles by using polyethylene glycol, adding the rest humectant, then adding a thickening agent, stirring and homogenizing, sequentially adding a flavoring agent, polyphosphate, a surfactant and water, and uniformly stirring to obtain a mixture A;
(2) adding a friction agent into the mixture A, vacuumizing a container containing the mixture A, and uniformly stirring the mixture A and the friction agent to obtain a mixture B;
(3) adding essence into the mixture B, stirring, homogenizing, and degassing to obtain toothpaste.
By adopting the technical scheme, the toothpaste product has the effects of resisting bacteria, preventing decayed teeth and relieving periodontal disease and gingivitis. Firstly, polyethylene glycol is used for dissolving polydopamine particles, so that the polyethylene glycol and the polydopamine particles act to functionalize the surfaces of the polydopamine particles, the dispersion degree of the polydopamine particles is increased, and then other components are compounded, so that the stability of the finally prepared toothpaste body is ensured.
Detailed Description
The following is further detailed by way of specific embodiments:
examples 1-6 are the bacteriostatic anticariogenic compositions of the present invention, and the ingredients and contents (weight percent) information are shown in table 1. The antibacterial and anticarious composition comprises the following components in percentage by weight: 1-30% of polydopamine particles, and the balance of polyphosphate. The weight percentage of polydopamine particles is preferably 5-25%. Wherein the polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, calcium polyphosphate, strontium polyphosphate and zinc polyphosphate.
Wherein, polydopamine granule is purchased from Sian Ruixi biological technology limited company, the grain diameter of the granule is more than or equal to 900nm, the chemical grade, the specific information is as follows:
Figure BDA0002228361650000051
sodium polyphosphate was purchased from Chemische Fabrik company (Buden-heim, Germany, Na)(n+2)PnO(3n+1)N ≈ 40). The calcium polyphosphate, the zinc polyphosphate, the strontium polyphosphate and the magnesium polyphosphate are prepared from sodium polyphosphate. The specific preparation method of the calcium polyphosphate comprises the following steps: adding 3g of CaCl2·2H2Dissolving O in absolute ethyl alcohol, adding 1g of sodium polyphosphate to obtain a reaction system, adjusting the pH value of the reaction system to 6, and stirring the reaction system for 5 hours. After the reaction is finished, filtering to obtain a solid phase, washing the solid phase by using absolute ethyl alcohol, then placing the solid phase part in a 60 ℃ oven for drying, and sieving to obtain calcium polyphosphate, wherein the aperture of a sieve is 100 mu m. Preparation method of polyphosphate phosphate and preparation method of polyphosphate phosphate2·2H2Replacement of O by ZnCl2. Preparation method of strontium polyphosphate and preparation method of calcium polyphosphate, only CaCl is added2·2H2Replacement of O with SrCl2. Preparation method of magnesium polyphosphate and preparation method of calcium polyphosphate, only CaCl is added2·2H2Replacement of O with MgCl2. After the preparation of calcium polyphosphate, zinc polyphosphate, strontium polyphosphate, and magnesium polyphosphate was completed, the calcium polyphosphate, zinc polyphosphate, strontium polyphosphate, and magnesium polyphosphate were subjected to composition analysis using EDX spectroscopy (X-ray energy dispersion spectroscopy). The calcium polyphosphate contains a large amount of calcium element, phosphorus element, oxygen element and a small amount of sodium element; the zinc polyphosphate contains a large amount of zinc element, phosphorus element, oxygen element and a small amount of sodium element; the strontium polyphosphate contains a large amount of strontium elements, phosphorus elements, oxygen elements and a small amount of sodium elements; the magnesium polyphosphate contains a large amount of magnesium element and phosphorus elementAnd oxygen, and small amounts of sodium. The EDX spectrum analysis result shows that the polyphosphate radical fully complexes calcium ions, zinc ions, strontium ions and magnesium ions, and the calcium polyphosphate, the zinc polyphosphate, the strontium polyphosphate and the magnesium polyphosphate are successfully prepared.
Table 1: EXAMPLES 1-6 information on the composition of the bacteriostatic anticariogenic composition
Figure BDA0002228361650000052
Figure BDA0002228361650000061
Examples 7-16 show toothpastes containing bacteriostatic and anticariogenic compositions and methods of making the same
The following are general formulations and methods of preparation of the toothpastes of examples 7-16:
the toothpaste containing the antibacterial and anticarious composition comprises the antibacterial and anticarious composition, an abrasive, a thickening agent, a humectant, a flavoring agent, a surfactant, essence and water. The weight percentage of each component is as follows: 0.025-0.5% of polydopamine particles, 1.2-2% of polyphosphate, 5-70% of humectant, 0-60% of abrasive, 0.3-10% of thickening agent, 0.1-20% of surfactant, 0.1-2% of flavoring agent, 0.1-5% of essence, 0-0.25% of preservative and the balance of water.
Wherein, the weight percentage of the humectant is preferably 20-40%, the humectant comprises polyethylene glycol and the rest humectant, and the rest humectant comprises one or more than one of glycerol, sorbitol and propylene glycol.
The weight percentage of the abrasive is preferably 20-50%, and the abrasive is one or a mixture of more than one of calcium carbonate, hydrated silica, calcium hydrogen phosphate and calcium pyrophosphate.
The thickener is preferably 0.5-2 wt% and is one or more of hydroxyethyl cellulose, carboxymethyl cellulose, carrageenan, xanthan gum, sodium polyacrylate and carbomer.
The weight percentage of the surfactant is preferably 0.1-3%, the surfactant is a mixture of one or more than one of anionic, cationic, amphoteric and nonionic surfactants, and specifically comprises: the surfactant is one or more of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium sulfur sulfonate and cocamidopropyl betaine.
The flavoring agent is preferably 0.1-0.5 wt%, and the flavoring agent is saccharin sodium or sucralose.
The weight percentage of the essence is preferably 0.1-2%, and the essence is one or more of herba Menthae essence, Mentha spicata essence, Mentha piperita essence and anethole.
The polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, strontium polyphosphate, calcium polyphosphate and zinc polyphosphate. The source of polyphosphate is detailed in examples 1-6.
The weight percentage of the water is preferably 8-30%, and pure water is adopted.
The preparation method of the toothpaste comprises the following steps:
(1) dissolving polydopamine particles by using polyethylene glycol, adding the rest humectant, then adding a thickening agent, stirring and homogenizing, sequentially adding a flavoring agent, polyphosphate, a surfactant and water, and uniformly stirring to obtain a mixture A;
(2) adding a friction agent into the mixture A, vacuumizing a container containing the mixture A, and uniformly stirring the mixture A and the friction agent to obtain a mixture B;
(3) adding essence into the homogeneous mixture B, stirring, homogenizing, and degassing to obtain toothpaste.
The specific formulation of the toothpaste of examples 8-17 is shown in table 2.
Table 2: example 7-example 16 parameter information
Figure BDA0002228361650000071
Example 8-the specific preparation method of the toothpaste in example 17 was: adding polyethylene glycol to dissolve polydopamine particles in a paste making machine, adding sodium carboxymethylcellulose and glycerol, stirring and homogenizing, adding saccharin sodium, polyphosphate (magnesium polyphosphate, calcium polyphosphate, zinc polyphosphate, strontium polyphosphate or sodium polyphosphate), sodium lauryl sulfate and water, and uniformly stirring; adding abrasive (friction agent) silicon dioxide, vacuumizing a material containing cavity in the paste making machine, and stirring and mixing the materials in the paste making machine uniformly; and finally adding essence (mint essence), stirring and homogenizing, and degassing to finish the preparation of the toothpaste.
Experimental example 1: fractional antibacterial concentration (FIC)
Mixing polydopamine particles with different concentrations and polyphosphate by adopting an agar dilution method, dissolving the mixture in an agar culture medium, then dibbling test bacteria, and determining the minimum inhibitory concentration (MIC value) of an antibacterial substance for inhibiting the growth of the test bacteria according to whether the test bacteria grow or not.
FIC index (MIC) was calculated from MICs of the two substances alone and in combinationCombination of A drugs/MICFor A prescriptions+MICCombination of B drugs/MICFor B prescriptions). When the FIC index is less than or equal to 0.75, the FIC index and the FIC index have synergistic action; when the FIC index is more than 0.75 and less than or equal to 1, the FIC index and the FIC index have an additive effect; when 1 < FIC index ≦ 2, it means that they are irrelevant.
The MIC values of polydopamine particles and polyphosphate, and the FIC index after the combination of the two, are shown in tables 3-7.
Table 3: experimental result of joint use of polydopamine and calcium polyphosphate
Figure BDA0002228361650000081
Table 4: experimental result of combined use of polydopamine and sodium polyphosphate
Figure BDA0002228361650000082
Table 5: experimental result of joint use of polydopamine and magnesium polyphosphate
Figure BDA0002228361650000083
Table 6: experimental result of combined use of polydopamine and strontium polyphosphate
Figure BDA0002228361650000084
Table 7: experimental result of joint use of polydopamine and zinc polyphosphate
Figure BDA0002228361650000091
According to the test results, the MIC values of the polydopamine particles and the polyphosphate on the streptococcus mutans and the porphyromonas gingivalis and the FIC values after the combination of the polydopamine particles and the polyphosphate are obtained, and the FIC indexes of each group are less than 0.75 by referring to the judgment standard of the FIC indexes, which shows that the polydopamine particles and the polyphosphate have synergistic effect on the streptococcus mutans and the porphyromonas gingivalis.
Experimental example 2: bacteriostatic test for toothpaste
1. Toothpaste sample acquisition
To verify the bacteriostatic anticariogenic effect of the toothpastes of the present invention, toothpastes not added with polydopamine particles but added with polyphosphate (group 2 in table 8), and toothpastes added with polydopamine particles and polyphosphate (group 4 in table 8), and controls of the two toothpastes (groups 1 and 3 in table 8) were prepared, and the specific formulations are shown in table 8.
Table 8: formulation information for groups 1-4 in Experimental example 2
Figure BDA0002228361650000092
The four toothpaste groups shown in Table 8 were mixed and dissolved in agar medium by agar dilution method according to the minimum inhibitory concentration test method of the Disinfection technical Specification (2.1.8.3) of 2002 by Ministry of health, and then tested bacteria were inoculated, and the minimum concentration of the antibacterial substance inhibiting the growth of the tested bacteria was determined according to the growth of the bacteria, and the results are shown in Table 9. According to experimental data, aiming at two common oral bacteria (streptococcus mutans and porphyromonas gingivalis), the MIC value of the combined use of the polydopamine particles and the polyphosphate is lower than that of the polydopamine particles and the polyphosphate, so that the polydopamine particles and the polyphosphate are applied to the preparation of toothpaste at the same time, the toothpaste can obtain a better antibacterial effect, and the polydopamine particles and the polyphosphate have a synergistic effect in the toothpaste.
Table 9: experimental example 2, groups 1 to 4
Figure BDA0002228361650000101
Experimental example 3: toothpaste stability test
According to the method, 6 groups of toothpastes are prepared and subjected to stability test according to the GB/T8372-2017 standard, and the specific formula proportion and the stability test result of each group of toothpastes are shown in the table 10. According to the experimental results, polyethylene glycol is not added in groups 1-3, so that poly-dopamine particles are easy to aggregate, and the overall stability of the toothpaste is affected; in groups 4-6, the addition of polyethylene glycol can stabilize polydopamine granule property, prevent aggregation, and improve overall stability of toothpaste.
Table 10: formulation information and test results of groups 1 to 6 in Experimental example 3
Component (A)/content Group 1 2 groups of Group 3 4 groups of 5 groups of 6 groups of
Glycerol 30 30 —— —— —— 30
Polyethylene glycol —— —— —— 5 5 5
Sorbitol —— 25 25 25 —— ——
Propylene glycol —— —— 4 —— 4 ——
Polydopamine particles 0.3 0.3 0.3 0.3 0.3 0.3
Silicon dioxide 20 20 20 20 20 20
Sodium lauroyl sarcosinate 1.2 1.2 1.2 1.2 1.2 1.2
Xanthan gum 1.0 1.0 1.0 1.0 1.0 1.0
Carboxymethyl cellulose gum 0.3 0.3 0.3 0.3 0.3 0.3
Saccharin sodium salt 0.2 0.2 0.2 0.2 0.2 0.2
Sodium thiosulfonate 1.0 1.0 1.0 1.0 1.0 1.0
Calcium polyphosphate 1.3 1.3 1.3 1.3 1.3 1.3
Mint essence 1.2 1.2 1.2 1.2 1.2 1.2
Water (W) Balance of Balance of Allowance of Balance of Balance of Balance of
Stability of Instability of the film Instability of the film Instability of the film Stabilization Stabilization Stabilization
The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several variations and modifications can be made, which should also be considered as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the utility of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.

Claims (9)

1. An antibacterial and anticarious composition is characterized by consisting of polydopamine particles and polyphosphate; the polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, calcium polyphosphate, strontium polyphosphate and zinc polyphosphate.
2. The bacteriostatic anticariogenic composition according to claim 1, wherein the weight percentage of the polydopamine particles is 1-30%, and the balance is polyphosphate.
3. Use of a bacteriostatic anticariogenic composition according to claim 2 for the preparation of toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.
4. The use according to claim 3, wherein the raw materials of the toothpaste comprise abrasives, thickeners, humectants, flavoring agents, surfactants, perfumes, water, preservatives and bacteriostatic anticaries compositions; the antibacterial and anticarious composition consists of polydopamine particles and polyphosphate.
5. The use of claim 4, wherein the humectant comprises polyethylene glycol and the remaining humectant is one or a mixture of more than one of glycerin, sorbitol and propylene glycol; the preservative is one or a mixture of more than one of sodium benzoate, hydroxybenzene esters, potassium sorbate and cymene.
6. The use according to claim 5, wherein the thickener is one or a mixture of more than one of hydroxyethylcellulose, xanthan gum, carrageenan, carbomer and hydroxymethylcellulose.
7. The use according to claim 6, wherein the surfactant is one or more of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium thiolsulfonate and cocamidopropyl betaine.
8. The use of claim 7, wherein the toothpaste comprises the following raw materials by weight percent: 0.025-0.5% of polydopamine particles, 1.2-2% of polyphosphate, 5-70% of humectant, 0-60% of abrasive, 0.3-10% of thickener, 0.1-20% of surfactant, 0.1-2% of flavoring agent, 0.1-5% of essence, 0-0.25% of preservative and the balance of water.
9. Use according to claim 8, wherein the toothpaste is prepared by a process comprising:
(1) dissolving polydopamine particles by using polyethylene glycol, adding the rest humectant, then adding a thickening agent, stirring and homogenizing, sequentially adding a flavoring agent, polyphosphate, a surfactant and water, and uniformly stirring to obtain a mixture A;
(2) adding a friction agent into the mixture A, vacuumizing a container containing the mixture A, and uniformly stirring the mixture A and the friction agent to obtain a mixture B;
(3) adding essence into the mixture B, stirring, homogenizing, and degassing to obtain toothpaste.
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