CN110558310A - isolated organ perfusion liquid-changing system - Google Patents
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- 239000012530 fluid Substances 0.000 claims abstract description 110
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D27/00—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00
- G05D27/02—Simultaneous control of variables covered by two or more of main groups G05D1/00 - G05D25/00 characterised by the use of electric means
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Abstract
The application relates to an isolated organ perfusion fluid exchange system, including: a pipeline power circulation subsystem which is communicated with the isolated organ perfusion system; the liquid exchange subsystem is communicated with the power circulation subsystem of the connecting pipeline; the control subsystem is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem; the fluid changing subsystem is used for acquiring and filtering perfusate of the isolated organ perfusion system and transmitting the supplementary fluid and the filtered perfusate to the isolated organ perfusion system through the pipeline power circulation subsystem; the control subsystem is used for obtaining waste liquid generation data in preset time, obtaining supplement data of supplement liquid according to the waste liquid generation data, and driving the liquid changing subsystem to transmit the supplement liquid to the pipeline power circulation subsystem according to the supplement data. The liquid balance can be realized in the system, the operation process of changing the liquid by the perfusate is simplified, the liquid change error is reduced, the liquid change precision is improved, and the secondary pollution in the liquid change process can be avoided.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to an isolated organ perfusion and fluid replacement system.
Background
In organ transplantation, the development of organ transplantation is severely limited by the shortage of donor organs. At present, organs used for transplantation are mainly well-conditioned donor organs, a large number of marginal donor organs are generally abandoned, and development of ex vivo Mechanical Perfusion (MP) technology makes it possible to apply the marginal donor organs in clinics.
However, long-time isolated organ perfusion can make isolated organ produce a large amount of metabolites, such as water, lactic acid, inorganic salts and urea, and these metabolites stay in isolated organ's perfusate, can follow extracorporeal circulation pipe-line system reentry isolated organ in, when these metabolites accumulate when a certain amount, if can not discharge in time, can cause isolated organ's further damage, can't save marginal donor organ to the possibility of transplantation has been reduced.
In the implementation process, the inventor finds that at least the following problems exist in the conventional technology: the traditional liquid changing process of perfusate of isolated organs has the disadvantages of complex operation, liquid changing error, low liquid changing precision and easy secondary pollution.
Disclosure of Invention
On the basis, the isolated organ perfusion fluid-changing system is necessary to solve the problems that the traditional isolated organ perfusion fluid-changing process is complex to operate, the fluid-changing error exists, the fluid-changing precision is low, and secondary pollution is easily caused.
In order to achieve the above object, an embodiment of the present invention provides an isolated organ perfusion fluid exchange system, including:
The pipeline power circulation subsystem is used for being communicated with the isolated organ perfusion system;
the liquid changing subsystem is communicated with the pipeline power circulation subsystem; the fluid changing subsystem is used for acquiring and filtering perfusate of the isolated organ perfusion system through the pipeline power circulation subsystem, and is also used for transmitting supplementary fluid and the filtered perfusate to the isolated organ perfusion system through the pipeline power circulation subsystem;
the control subsystem is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem;
The control subsystem is used for driving the pipeline power circulation subsystem; the control subsystem is further used for obtaining waste liquid generation data within a preset time, obtaining supplement data of the supplement liquid according to the waste liquid generation data, and driving the liquid changing subsystem to transmit the supplement liquid to the pipeline power circulation subsystem according to the supplement data.
in one embodiment, the pipeline power cycle subsystem comprises a first pipeline assembly, a second pipeline assembly and a power pump communicatively coupled to the control subsystem;
The power pump is communicated with the isolated organ perfusion system through a first pipeline assembly; the power pump is communicated with the liquid changing subsystem through a second pipeline assembly.
In one embodiment, the power pump is a centrifugal pump, a roller pump, a peristaltic pump, or a dialysis pump.
In one embodiment, the pipeline power cycle subsystem further comprises a first flow sensor disposed in the first pipeline component, or the second pipeline component; the first flow sensor is in communication connection with the control subsystem;
the first flow sensor is an ultrasonic flow sensor, an optical flow sensor or an electrical flow sensor.
In one embodiment, the liquid changing subsystem comprises a liquid supplementing device, a filtering device, a waste liquid collecting device and a waste liquid collecting module;
the liquid supplementing equipment is communicated with the pipeline power circulation subsystem; the filtering equipment is communicated with the pipeline power circulation subsystem; the waste liquid collecting device is communicated with the filtering device;
The liquid supplementing device, the waste liquid collecting device and the waste liquid collecting module are in communication connection with the control subsystem respectively.
In one embodiment, the waste liquid collecting module is a second flow sensor arranged on the waste liquid collecting device, a weight sensor arranged on the waste liquid collecting device, or a pressure sensor arranged on the input end of the filtering device; the second flow sensor, the weight sensor and the pressure sensor are all in communication connection with the control subsystem;
the waste liquid collecting device comprises a waste liquid collecting device communicated with the waste liquid cavity and a first liquid level sensor arranged on the waste liquid collecting device; the first level sensor is in communication with the control subsystem.
in one embodiment, the liquid supplementing equipment comprises a liquid supplementing pipeline circulating assembly which is communicated and connected with the pipeline power circulating subsystem, a liquid adding device which is communicated and connected with the control subsystem, and a liquid storage tank which is communicated and connected between the liquid adding device and the liquid supplementing pipeline circulating assembly;
And the liquid supplementing pipeline circulating assembly is in communication connection with the control subsystem.
In one embodiment, the liquid supplementing device further comprises a third flow sensor arranged on the liquid supplementing pipeline circulating assembly and a second liquid level sensor arranged on the liquid storage tank;
And the third flow sensor and the second liquid level sensor are respectively in communication connection with the control subsystem.
In one embodiment, the control subsystem comprises an upper computer device and a lower computer device connected with the upper computer device;
The lower computer device is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem.
In one embodiment, the control subsystem further comprises an alarm device connected to the lower computer device.
One of the above technical solutions has the following advantages and beneficial effects:
The pipeline-based power circulation subsystem is in through connection between the isolated organ perfusion system and the liquid exchange subsystem; the control subsystem is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem; the control subsystem can drive the pipeline power circulation subsystem to enable perfusate of the isolated organ perfusion system to flow to the fluid changing subsystem through the pipeline power circulation subsystem, the fluid changing subsystem can filter the received perfusate to obtain filtered perfusate, and the filtered perfusate is transmitted back to the isolated organ perfusion system through the pipeline power circulation subsystem; the control subsystem can also obtain waste liquid generation data in a preset time, obtain supplementary data of supplementary liquid according to the waste liquid generation data, and drive the liquid changing subsystem to transmit the supplementary liquid to the pipeline power circulation subsystem according to the supplementary data. The small molecule metabolite in the filtration perfusate is realized, the supplement liquid required by the perfusion of the isolated organ is automatically supplemented, the perfusate balance of the whole system is kept, the isolated edge donor organ is effectively preserved or repaired, the operating process of perfusate liquid changing is simplified, the liquid changing error is reduced, the liquid changing precision is improved, and meanwhile, the secondary pollution in the liquid changing process can be avoided.
drawings
FIG. 1 is a schematic diagram of a first configuration of an isolated organ perfusion fluid exchange system according to an embodiment;
FIG. 2 is a schematic diagram of a second configuration of an ex vivo organ perfusion fluid exchange system according to an embodiment;
FIG. 3 is a schematic diagram of a third embodiment of an ex vivo organ perfusion fluid exchange system;
FIG. 4 is a diagram illustrating a fourth configuration of an ex vivo organ perfusion fluid exchange system according to an exemplary embodiment;
FIG. 5 is a schematic diagram of a fifth embodiment of an ex vivo organ perfusion fluid exchange system;
FIG. 6 is a diagram illustrating a sixth configuration of an ex vivo organ perfusion fluid exchange system according to an exemplary embodiment;
FIG. 7 is a seventh schematic diagram of an ex vivo organ perfusion fluid exchange system according to one embodiment;
FIG. 8 is a schematic diagram of an eighth configuration of an ex vivo organ perfusion fluid exchange system in an embodiment.
Detailed Description
to facilitate an understanding of the present application, the present application will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present application are shown in the drawings. This application may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein in the description of the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
At present, the metabolite is excreted from an isolated organ, usually at certain time intervals, and the perfusate with the metabolite is replaced by a new perfusate, but the following problems are easily caused: in the replacement process of the perfusion fluid, the operation is complicated, the requirement on the sterilization environment is high, and the pollution is easily caused; in the replacement process, the mechanical perfusion circulation updating speed is high, so that the new and old perfusates and the metabolites are quickly mixed, and the discharge effect of the metabolites is reduced; the perfusate is very expensive and has large replacement amount, thereby causing great waste and improving the cost of transplantation; the condition that air bubbles appear in the circulation pipeline of the isolated organ is easily caused in the replacement process, so that the isolated organ is damaged.
in the isolated organ perfusion and fluid replacement system provided by the application, the isolated organ perfusion and fluid replacement subsystem is connected between the isolated organ perfusion system and the fluid replacement subsystem through the pipeline power circulation subsystem; the control subsystem is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem; can realize continuous filtration of perfusate and discharge the metabolic products such as redundant water, lactic acid, inorganic salt and the like generated in an isolated organ perfusion system; and automatically replenishes new replenisher for the isolated organ perfusion system, keeps the equilibrium of the perfusate of the whole system, prevents the isolated organ from being damaged due to the accumulation of metabolites, simplifies the operation process of perfusate liquid changing and improves the liquid changing efficiency.
In one embodiment, as shown in fig. 1, there is provided an ex vivo organ perfusion fluid exchange system comprising:
The pipeline power circulation subsystem 110, the pipeline power circulation subsystem 110 is used for communicating with the isolated organ perfusion system;
The liquid changing subsystem 120, the liquid changing subsystem 120 is communicated with the pipeline power circulation subsystem 110; the fluid changing subsystem 120 is used for acquiring and filtering perfusate of the isolated organ perfusion system through the pipeline power circulation subsystem 110, and is also used for transmitting supplementary fluid and the filtered perfusate to the isolated organ perfusion system through the pipeline power circulation subsystem 110;
The control subsystem 130 is in communication connection with the pipeline power circulation subsystem 110 and the liquid changing subsystem 120 respectively;
Wherein, the control subsystem 130 is used for driving the pipeline power circulation subsystem 110; the control subsystem 130 is further configured to obtain waste liquid generation data within a preset time, obtain supplement data of the supplement liquid according to the waste liquid generation data, and drive the liquid changing subsystem 120 to transmit the supplement liquid to the pipeline power circulation subsystem 110 according to the supplement data.
in particular, an ex vivo organ perfusion system refers to a preservation or repair system that perfuses an ex vivo organ. The line power cycle subsystem 110 may be used to deliver the perfusion and the replenishment solutions as well as provide power to deliver the perfusion and the replenishment solutions. The pipeline power circulation subsystem 110 is in through connection with the isolated organ perfusion system, the pipeline power circulation subsystem 110 is in through connection with the liquid changing subsystem 120, and the pipeline power circulation subsystem 110 can pump the perfusion liquid with the metabolite into the liquid changing subsystem 120. The fluid changing subsystem 120 may be configured to filter the received perfusate to obtain a filtered perfusate, and further may transmit the filtered perfusate back to the isolated organ perfusion system through the pipeline power circulation subsystem 110. For example, the fluid exchange subsystem 120 may be used to filter out unwanted small molecule metabolites (e.g., water, lactic acid, inorganic salts, etc.) from the perfusate. It should be noted that the perfusate output from the isolated organ perfusion system refers to the perfusate to be filtered.
Based on the control subsystem 130 communicatively coupling the pipeline power cycle subsystem 110, the control subsystem 130 may drive the pipeline power cycle subsystem 110 such that the drive pipeline power cycle subsystem 110 provides transport piping and transport power for transporting the perfusion fluid and the replenishment fluid. Based on the control subsystem 130 being in communication connection with the liquid changing subsystem 120, the control subsystem 130 may obtain the waste liquid generation data within a preset time, and obtain the supplementary data of the supplementary liquid according to the waste liquid generation data. The control subsystem 130 can then drive the fluid replacement subsystem 120, so that the fluid replacement subsystem 120 transmits the supplementary fluid with a corresponding flow rate to the pipeline power circulation subsystem 110, and the perfusate balance of the isolated organ perfusion system is achieved.
optionally, the pipeline power circulation subsystem 110 may be connected to the circulation pipeline of the isolated organ perfusion system by a bypass or main pipeline connection. For example, the pipeline power circulation subsystem 110 is connected to the circulation pipeline of the isolated organ perfusion system in a bypass connection manner, and the fluid changing subsystem 120 can receive the perfusion fluid transmitted by the pipeline power circulation subsystem 110, continuously filter the small molecule metabolites in the perfusion fluid, automatically and continuously supplement a new supplement fluid required by the perfusion of the isolated organ, and keep the balance of the perfusion fluid of the whole system; the long-time preservation and repair of the isolated organ can be realized under the normal temperature environment, organ failure and damage caused by accumulation of harmful metabolites are prevented, and thrombus, inflammatory factors and other harmful substances in the isolated organ are effectively removed, so that the preservation state of the isolated organ is improved, the physiological state of the isolated organ is maintained or improved, the problems of pulmonary edema, renal toxicity, abnormal liver function, poor cardio-pulmonary oxygenation and the like are improved, the isolated edge donor organ is effectively preserved or repaired, and the utilization rate of the isolated organ is improved.
The isolated organ may be an isolated lung, an isolated kidney, an isolated heart, an isolated pancreas, or the like. The perfusate refers to a nutrient solution which can be used for preserving or repairing isolated organs; for example, the perfusate may be Steen solution, LPD solution, Perfadex solution, UW solution, cell preservation solution, blood, etc.
in the isolated organ perfusion and fluid exchange system, the control subsystem 130 can drive the pipeline power circulation subsystem 110, so that the perfusate of the isolated organ perfusion system flows to the fluid exchange subsystem 120 through the pipeline power circulation subsystem 110, the fluid exchange subsystem 120 can filter the received perfusate to obtain filtered perfusate, and the filtered perfusate is transmitted back to the isolated organ perfusion system through the pipeline power circulation subsystem 110; the control subsystem 130 may further obtain waste liquid generation data within a preset time, obtain supplementary data of the supplementary liquid according to the waste liquid generation data, and drive the liquid changing subsystem 120 to transmit the supplementary liquid corresponding to the supplementary data to the pipeline power circulation subsystem 110. The small molecule metabolite in the filtration perfusate is realized, the supplement liquid required by the perfusion of the isolated organ is automatically supplemented, the perfusate balance of the whole system is kept, the isolated edge donor organ is effectively preserved or repaired, the operating process of perfusate liquid changing is simplified, the liquid changing error is reduced, the liquid changing precision is improved, and meanwhile, the secondary pollution in the liquid changing process can be avoided.
in one embodiment, as shown in fig. 2, an ex vivo organ perfusion fluid exchange system is provided, comprising a pipeline power circulation subsystem 210, a fluid exchange subsystem 220 and a control subsystem 230; the pipeline power cycle subsystem 210 includes, among other things, a first pipeline assembly 212, a second pipeline assembly 214, and a power pump 216 communicatively coupled to a control subsystem 230. The power pump 216 is communicated with the isolated organ perfusion system through the first pipeline assembly 212; the power pump 216 is in communication with the fluid exchange sub-system 220 via the second conduit assembly 214.
In particular, first tubing assembly 212 may be used to deliver perfusate output by an ex vivo organ perfusion system, as well as to deliver supplemental and filtered perfusate to the ex vivo organ perfusion system. The first tubing assembly 212 includes, but is not limited to, tubing, two-way joints, three-way joints, micro-emboli filters, leukocyte-reduction filters, and bridge tubing. The second tubing assembly 214 may be used to deliver the perfusion fluid to be filtered to the fluid-changing subsystem, as well as to deliver the replenishment fluid and the filtered perfusion fluid output by the fluid-changing subsystem. The second tubing assembly 214 includes, but is not limited to, tubing, two-way joints, three-way joints, micro-embolus filters, leukocyte-reduction filters, and bridge tubing. The first tubing assembly 212 and the second tubing assembly 214 constitute a transfer path for the perfusion fluid and the replenishment fluid. The power pump 216 can be used to provide transmission power to the first pipeline assembly 212 and the second pipeline assembly 214, so as to continuously output the perfusate to be filtered to the isolated organ perfusion system, and automatically and continuously transmit the filtered perfusate and the supplementary fluid required for supplementing new isolated organ perfusion back to the isolated organ perfusion system, so as to keep the perfusate balance of the isolated organ perfusion system. Alternatively, the powered pump 216 may be, but is not limited to, a centrifugal pump, a roller pump, a peristaltic pump, or a resolver pump.
in one embodiment, as shown in FIG. 2, pipeline power cycle subsystem 210 further includes a first flow sensor 218 disposed in first pipeline assembly 212, or second pipeline assembly 214; the first flow sensor 218 is communicatively coupled to the control subsystem 230.
the first flow sensor 218 may be used to measure the flow of the perfusate to be filtered in the pipeline power cycle subsystem 210. Optionally, the first flow sensor 218 is an ultrasonic flow sensor, an optical flow sensor, or an electrical flow sensor. For example, the optical flow sensor may be a laser-based flow sensor; the electrical flow sensor may be an electromagnetic flow sensor or an inductive flow sensor.
Specifically, based on the first flow sensor 218 being communicatively coupled to the control subsystem 230, the control subsystem 230 may collect the flow rate of the perfusate to be filtered measured by the first flow sensor 218 within a preset time. The control subsystem 230 may then adjust the power of the power pump 216 in real time based on the flow rate of the perfusate to be filtered. For example, the control subsystem 230 can control the power of the power pump 216 to decrease when the flow rate of the perfusate to be filtered is too great; the control subsystem 230 can control the power pump 216 to increase when the flow rate of the perfusate to be filtered is too small.
It should be noted that the first flow sensor 218 may be disposed on the pipeline side of the first pipeline assembly 212 for transmitting the perfusate to be filtered, and the first flow sensor 218 may also be disposed on the pipeline side of the second pipeline assembly 214 for transmitting the perfusate to be filtered. Depending on the type of first flow sensor 218, the connection to the first tubing assembly 212 or the second tubing assembly 214 may be different, typically non-contact.
In the isolated organ perfusion and fluid replacement system, the power pump 216 is connected with the isolated organ perfusion system through the first pipeline assembly 212; the power pump 216 is communicated with the liquid changing subsystem 220 through the second pipeline assembly 214, and the power pump 216 provides transmission power for the first pipeline assembly 212 and the second pipeline assembly 214; the operating parameters of the power pump 216 are manipulated and adjusted by the control subsystem 230, and the control subsystem 230 may monitor the power pump 216 in real time. Based on the communication connection of the first flow sensor 218 with the control subsystem 230, the control subsystem 230 can monitor the flow rate of the perfusate to be filtered in real time. The flow rate of the perfusion fluid measured by the flow sensor 218 is determined by the operating parameters of the power pump 216. Meanwhile, the control subsystem 230 can adjust the power of the power pump in real time according to the flow of the perfusate to be filtered, so as to prevent the filtering pipeline from being over pressurized due to over-high flow or prevent the filtering rate from being reduced due to over-low flow. The method has the advantages of keeping the perfusion balance of the whole system, simplifying the operation process of changing the perfusate, reducing the error of changing the perfusate, improving the precision of changing the perfusate, and avoiding the secondary pollution in the process of changing the perfusate.
In one embodiment, as shown in fig. 3, an ex vivo organ fluid exchange system is provided, comprising a pipeline power cycle subsystem 310, a fluid exchange subsystem 320 and a control subsystem 330; the liquid changing subsystem 320 includes a liquid replenishing device 322, a filtering device 324, a waste liquid collecting device 326, and a waste liquid collecting module 328. The fluid infusion equipment 322 is communicated with the pipeline power circulation subsystem 310; the filtering device 324 is communicated with the pipeline power circulation subsystem 310; the waste liquid collecting device 326 is communicated with the filtering device 324; fluid replacement device 322, waste fluid collection device 326, and waste fluid collection module 328 are each communicatively coupled to control subsystem 330.
wherein the fluid replacement device 322 is operable to store a replacement fluid and to provide the replacement fluid to the isolated organ perfusion system; the filtration device 324 may be used to filter the perfusion fluid to be filtered; the waste liquid collecting device 326 can be used for collecting the substances filtered by the filtering device; waste collection module 328 may be used to collect corresponding data for the waste, for example, waste collection module may be but not limited to collecting the flow generated by the waste, the weight of the waste collected, or the pressure at which the waste is filtered, etc. The supplementary liquid contains nutrients required for normal metabolism of the isolated organ, such as antibiotics, vitamins, drugs, and buffers for adjusting the pH of the perfusate.
Specifically, the fluid replacement device 322 may be connected to the pipeline power circulation subsystem 310 in a bypass manner, so that new replacement fluid may be pumped into the isolated organ perfusion system through the pipeline power circulation subsystem 310. The filtering device 324 can be communicated with the isolated organ perfusion system through the pipeline power circulation subsystem 310, and the filtering device 324 can filter the perfusion solution to be filtered, so as to effectively filter metabolites generated by the isolated organ, such as excessive water, lactic acid, inorganic salts, harmful kidney poisons and the like; the waste liquid collecting device 326 can collect the substances filtered by the filtering device 324. The control subsystem 330 is connected based on the communication of the fluid infusion device 322, the control subsystem 330 can control the flow of the supplement fluid output by the fluid infusion device 322, and the control subsystem 330 can also be used for monitoring the residual capacity of the supplement fluid stored in the fluid infusion device 322, so that when the residual capacity of the supplement fluid is insufficient, the supplement fluid can be added in time, and the phenomenon that the perfusion fluid of the whole system is unbalanced due to the insufficient supplement fluid is prevented. Based on the waste liquid collecting device 326 being communicatively coupled to the control subsystem 330, the control subsystem 330 may monitor the amount of waste liquid collected by the waste liquid collecting device 326, preventing overfilling of the waste liquid collection in the waste liquid collecting device. Based on waste liquid collection module 328 communication connection control subsystem 330, waste liquid collection module 328 can give control subsystem with the data transmission who gathers, and then control subsystem can be according to the corresponding data (for example flow, pressure or weight etc.) of waste liquid, and the replenishment quantity of corresponding regulation replenishment liquid realizes keeping entire system's perfusate balanced, has simplified the operation process that the perfusate traded the liquid.
In one example, the waste liquid collection module is a second flow sensor arranged on the waste liquid collection device, a weight sensor arranged on the waste liquid collection device, or a pressure sensor arranged on the input end of the filtering device; the second flow sensor, the weight sensor and the pressure sensor are all in communication connection with the control subsystem;
for example, as shown in fig. 4, the second flow sensor is disposed in the waste liquid collecting device, and the second flow sensor can be used to collect the flow of waste liquid flowing to the waste liquid collecting device and transmit the collected flow of waste liquid to the control subsystem. And then the control subsystem can obtain the waste liquid of waste liquid in the preset time according to waste liquid flow and generate data (waste liquid yield and/or waste liquid yield rate), and according to waste liquid and generate data, obtain the supplementary data (such as supplementary volume) of supplementary liquid, and according to supplementary data, drive the liquid changing subsystem and transmit the supplementary liquid of corresponding supplementary data to pipeline power circulation subsystem, realize the filtration to the perfusate, and supplement the required supplementary liquid of isolated organ perfusion automatically, keep the perfusate balance of whole system.
for another example, as shown in fig. 5, the weight sensor is disposed in the waste liquid collecting device, and the weight sensor can be used to collect the weight of the waste liquid flowing into the waste liquid collecting device, and transmit the collected weight of the waste liquid to the control subsystem. And then the control subsystem can obtain the waste liquid of waste liquid in the preset time according to waste liquid weight and generate data (waste liquid yield and/or waste liquid generation rate), and according to waste liquid and generate data, obtain the supplementary data of supplementary liquid, and according to supplementary data, drive the liquid changing subsystem and transmit the supplementary liquid of corresponding supplementary data to pipeline power circulation subsystem, realize the filtration to the perfusate, and the required supplementary liquid of isolated organ perfusion is supplemented automatically, the perfusate of keeping whole system is balanced.
as another example, as shown in fig. 6, the pressure sensor is disposed at an input end of the filtering device, and the pressure sensor can be used to collect a line pressure when the waste liquid flows to the input end of the filtering device, and transmit the collected line pressure to the control subsystem. And then the control subsystem can obtain the waste liquid generation data (waste liquid generation amount and/or waste liquid generation rate) of the waste liquid within the preset time according to the waste pipeline pressure, and obtain the supplementary data of the supplementary liquid according to the waste liquid generation data, and according to the supplementary data, drive the liquid changing subsystem to transmit the supplementary liquid corresponding to the supplementary data to the pipeline power circulation subsystem, so as to realize the filtration of the perfusate, automatically supplement the supplementary liquid required by the perfusion of the isolated organ, and keep the balance of the perfusate of the whole system.
It should be noted that the waste liquid collecting module may also be any combination of the following sensors: a second flow sensor arranged on the waste liquid collecting device, a weight sensor arranged on the waste liquid collecting device, and a pressure sensor arranged on the input end of the filtering device.
In one embodiment, as shown in fig. 7, the waste liquid collecting device 720 includes a waste liquid collecting device 722 connected to the filtering device 710, and a first liquid level sensor 724 disposed on the waste liquid collecting device 722; the first level sensor 724 is communicatively coupled to the control subsystem 750.
the first level sensor 724 may be used to measure the volume of waste liquid collected in the waste liquid collecting device 722. The waste collection device 722 may be used to collect waste, for example, the waste collection device 722 may include a waste receptacle through which waste is collected.
specifically, the waste liquid collecting device 722 is in through connection with the filtering apparatus 710, and the waste liquid collecting device 722 can collect waste liquid generated after the filtering apparatus filters the perfusate; based on the communication connection of the first liquid level sensor 724 with the control subsystem 750, the first liquid level sensor 724 can measure the waste liquid collection condition of the waste liquid collection device 722 in real time, the control subsystem 750 can collect liquid level data measured by the first liquid level sensor 724, and then the control subsystem 750 can monitor the waste liquid collection condition of the waste liquid collection device 722 in real time; for example, when the control subsystem 750 detects that the waste liquid collecting device 722 is overfilled, it generates an early warning to prompt the user to dispose of the waste liquid collected in the waste liquid collecting device in time.
In one embodiment, as shown in fig. 7, the fluid replacement device 730 comprises a fluid replacement line circulation assembly 731 connected through the line power circulation subsystem 740, a fluid filling device 733 communicatively connected to the control subsystem 750, and a fluid storage member 735 connected through the fluid filling device 733 and the fluid replacement line circulation assembly 731; the fluid replacement circuit circulation assembly 731 is in communication with the control subsystem 750.
the make-up fluid circulation assembly 731 can be used to provide a transmission line for transmitting make-up fluid and transmission power; for example, the fluid replacement circuit circulation assembly 731 may include an infusion pump through which a replacement fluid is delivered and a circuit through which the replacement fluid is driven to flow through the circuit. The storage element 735 may be used to store a refill fluid, for example, the storage element 735 may be, but is not limited to, a reservoir or a pack; the filling device 733 may be used to add refill fluid to the reservoir 735. Optionally, the fluid infusion apparatus 730 further includes a fluid stop valve disposed in the pipeline. Wherein the liquid stop valve can be an automatic liquid stop valve; the liquid stop valve can be used to shut off the delivery of make-up liquid.
Specifically, the liquid storage part 735 is connected between the liquid adding device 733 and the liquid supplementing pipeline circulating component 731 in a penetrating manner, and the liquid supplementing pipeline circulating component 731 is connected with the pipeline power circulating subsystem 740 in a penetrating manner; the liquid supplementing pipeline circulation component 731 can be connected into the pipeline power circulation subsystem 740 in a bypass connection mode, supplementing liquid in the liquid storage component 735 can be pumped into the pipeline power circulation subsystem 740 through the liquid supplementing pipeline circulation component 731, and then flows into the isolated organ perfusion system through the pipeline power circulation subsystem 740, so that supplementing liquid required by isolated organ perfusion can be automatically supplemented, the perfusion liquid balance of the whole system is kept, the operation process of perfusate liquid changing is simplified, and the liquid changing efficiency is improved.
In one embodiment, as shown in fig. 7, the fluid replacement device 730 further includes a second flow sensor 737 disposed in the fluid replacement line circulation assembly 731, and a second fluid level sensor 739 disposed in the fluid storage member 735. The second flow sensor 737 and the second fluid level sensor 739 are each communicatively coupled to the control subsystem 750.
The second flow sensor 737 may be configured to measure a flow rate of the replenishment liquid in the replenishment liquid circulation assembly 731. Optionally, second flow sensor 737 is an ultrasonic flow sensor, an optical flow sensor, or an electrical flow sensor. The second level sensor 739 may be used to measure the remaining volume of refill liquid in the reservoir 735.
Specifically, the control subsystem 750 may collect the replenishment flow rate of the replenishment liquid measured by the second flow sensor 737 based on the second flow sensor 737 communicatively coupled to the control subsystem 750. The control subsystem 750 may further monitor the replenishment flow rate of the replenishment liquid output by the liquid storage member 735 in real time; for example, the control subsystem 750 can achieve error early warning on the actually acquired replenishment flow, adjust the flow of the replenishment liquid in time, and improve the accuracy of perfusion and liquid replacement. Based on the second liquid level sensor 739 communicatively connected to the control subsystem 750, the control subsystem 750 may collect the remaining capacity of the replenishment liquid measured by the second liquid level sensor 739, and the control subsystem 750 may monitor the remaining capacity of the replenishment liquid in the liquid storage member 735 in real time. For example, when the second level sensor 739 detects that the liquid level in the liquid storage member 735 is lower than the predetermined threshold, the control subsystem 750 can control the liquid adding device 733 to add new replenishing liquid to the liquid storage member 735, so as to prevent the replenishing liquid in the liquid storage member 735 from being insufficient, and the perfusion liquid in the system is unbalanced.
In the isolated organ perfusion and fluid exchange system, the pipeline power circulation subsystem provides power to pump the perfusate to be filtered from the isolated organ into the fluid exchange subsystem, the filtered perfusate is obtained after the filtration of the perfusate to be filtered by the filtration equipment, and the filtered perfusate and the supplementary fluid provided by the fluid exchange subsystem are pumped into the isolated organ perfusion system through the pipeline power circulation subsystem and flow back into the isolated organ perfusion system, wherein the discharge amount of the waste liquid and the supplementary fluid are kept consistent, so that the perfusate of the isolated organ perfusion system is always in a balanced state.
in one embodiment, as shown in fig. 8, an ex vivo organ perfusion fluid exchange system is provided, comprising a pipeline power circulation subsystem 810, a fluid exchange subsystem 820 and a control subsystem 830; the control subsystem 830 includes a host device 832, and a host device 832 connected to the host device 834. The lower computer device 834 is respectively in communication connection with the pipeline power circulation subsystem 810 and the liquid changing subsystem 820.
The lower computer device 834 may have a processing device of an ARM (Advanced RISC Machines) processor, and the upper computer device 832 may be, but not limited to, a computer, a notebook computer, a smart phone, a tablet computer, a portable wearable device, and the like.
Specifically, based on the communication connection between the upper computer device 832 and the lower computer device 834, the upper computer device 832 may transmit the collected operation data of each subsystem to the lower computer device 834, and may use the received data for the external display device to display. Based on the fact that the lower computer device 834 is respectively in communication connection with the pipeline power circulation subsystem 810 and the liquid changing subsystem 820, the lower computer device 834 can be used for transmitting (collecting, receiving or issuing and the like) operation parameters among the subsystems and is in communication with the upper computer device 832, and therefore the operation state of the whole system is monitored in real time.
in one example, the lower computer device can be divided into a fluid infusion control unit, a filtration control unit, a waste fluid control unit, and a pipe transfer control unit. The upper computer device can comprise a liquid supplementing parameter unit which is in communication connection with the liquid supplementing control unit, a filtering parameter unit which is in communication connection with the filtering control unit, a waste liquid parameter unit which is in communication connection with the waste liquid control unit and a pipeline transmission parameter unit which is in communication connection with the pipeline transmission control unit. The parameter units (the fluid infusion parameter unit, the filtration parameter unit, the waste liquid parameter unit and the pipeline transmission parameter unit) of the upper computer device are respectively used for receiving corresponding operation parameters, analyzing the operation parameters, issuing control instructions and the like.
In one particular embodiment, as shown in fig. 8, the control subsystem 830 further includes an alarm device 836 coupled to the lower computer device 834.
the alarm device 836 may be a buzzer or a flashing light, or may be a combination of a buzzer and a flashing light.
Specifically, based on the alarm device 836 being connected to the lower computer device 834, when the lower computer device 834 monitors an abnormality (such as an abnormal condition including but not limited to an abnormal flow rate of the replenishment liquid, an abnormal remaining volume of the replenishment liquid, a bubble in the pipe, an abnormal system or storage, etc.), the alarm device 836 is triggered, so that the alarm device 836 sends out an alarm message.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. An ex vivo organ perfusion fluid exchange system, comprising:
the pipeline power circulation subsystem is used for being communicated with the isolated organ perfusion system;
The liquid changing subsystem is communicated with the pipeline power circulation subsystem; the liquid changing subsystem is used for acquiring and filtering perfusate of the isolated organ perfusion system through the pipeline power circulation subsystem, and is also used for transmitting supplementary liquid and the filtered perfusate to the isolated organ perfusion system through the pipeline power circulation subsystem;
The control subsystem is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem;
wherein the control subsystem is used for driving the pipeline power circulation subsystem; the control subsystem is further used for obtaining waste liquid generation data within a preset time, obtaining supplement data of the supplement liquid according to the waste liquid generation data, and driving the liquid changing subsystem to transmit the supplement liquid to the pipeline power circulation subsystem according to the supplement data.
2. the isolated organ perfusion fluid exchange system of claim 1, wherein the line power circulation subsystem comprises a first line assembly, a second line assembly, and a power pump communicatively coupled to the control subsystem;
The power pump is communicated with the isolated organ perfusion system through the first pipeline assembly; and the power pump is communicated with the liquid changing subsystem through the second pipeline assembly.
3. The isolated organ perfusion fluid exchange system of claim 2, wherein the powered pump is a centrifugal pump, a roller pump, a peristaltic pump, or a dialysis pump.
4. The isolated organ perfusion fluid exchange system of claim 2, wherein the line power cycle subsystem further comprises a first flow sensor disposed in the first line assembly or the second line assembly; the first flow sensor is in communication with the control subsystem;
The first flow sensor is an ultrasonic flow sensor, an optical flow sensor or an electrical flow sensor.
5. The isolated organ perfusion fluid exchange system of claim 1, wherein the fluid exchange subsystem comprises a fluid infusion device, a filtration device, a waste fluid collection device, and a waste fluid collection module;
The liquid supplementing equipment is communicated with the pipeline power circulation subsystem; the filtering equipment is communicated with the pipeline power circulation subsystem; the waste liquid collecting device is communicated with the filtering device;
The liquid supplementing device, the waste liquid collecting device and the waste liquid collecting module are in communication connection with the control subsystem respectively.
6. the isolated organ perfusion fluid exchange system according to claim 5, wherein the waste fluid collection module is a second flow sensor disposed on the waste fluid collection device, or a weight sensor disposed on the waste fluid collection device, or a pressure sensor disposed on an input end of the filtering device; the second flow sensor, the weight sensor, and the pressure sensor are all in communication with the control subsystem;
The waste liquid collecting equipment comprises a waste liquid collecting device which is in through connection with the filtering equipment, and a first liquid level sensor which is arranged on the waste liquid collecting device; the first level sensor is in communication with the control subsystem.
7. The isolated organ perfusion fluid exchange system according to claim 6, wherein the fluid infusion apparatus comprises a fluid infusion line circulation assembly in communication with the line power circulation subsystem, a fluid infusion device in communication with the control subsystem, and a fluid reservoir in communication with and between the fluid infusion device and the fluid infusion line circulation assembly;
And the liquid supplementing pipeline circulating assembly is in communication connection with the control subsystem.
8. The isolated organ perfusion fluid exchange system according to claim 7, wherein the fluid replacement device further comprises a third flow sensor disposed on the fluid replacement line circulation assembly, and a second fluid level sensor disposed on the fluid reservoir;
The third flow sensor and the second liquid level sensor are respectively in communication connection with the control subsystem.
9. The ex vivo organ perfusion fluid exchange system of claim 1, wherein the control subsystem comprises an upper computer device, and a lower computer device connected to the upper computer device;
the lower computer device is respectively in communication connection with the pipeline power circulation subsystem and the liquid changing subsystem.
10. The ex vivo organ perfusion fluid exchange system of claim 9, wherein the control subsystem further comprises an alarm device coupled to the lower computer device.
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Application publication date: 20191213 |