CN1105572C - Compound rhododendron senivainii granule and its preparing method - Google Patents
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Abstract
The present invention belongs to a Chinese patent medicine granule and a preparation method thereof. The granule is composed of seniavin rhododendron roots, sarcandra and yellow wood, and after, the seniavin rhododendron roots, the sarcandra and the yellow wood are decocted and boiled. Then, residues are decocted and boiled, filtered solutions are merged and are concentrated, and alcohol is added. After the filtered solutions and the alcohol are filtrated, extracturm is boiled, is sterilized, is cooled, is added with dextrin, and is sprayed with powders. After the extracturm is dried and pulverized, right amount of dextrin is added. Granules are made and are dried, and the split charging of the granules is carried out. The compound seniavin rhododendron root granule integrates cough relief, phlegm resolving, inflammation relief and asthma prevention into a whole, has a characteristic of obvious clinic curative effect, especially the cure of difficult miscellaneous diseases-old age acute bronchitis and chronic bronchitis without side effects. The characteristic of the compound seniavin rhododendron root granule can not be achieved by other antitussive.
Description
The present invention relates to Chinese patent medicine and preparation method thereof.
Rhododendron seniavinii is nontoxic Cuculidae plant in the prescription, and its Main Ingredients and Appearance farrerol has tangible sputum diluting effect, and it can make the viscosity of expectorant reduce, and is easy to expectoration, plays the cough-relieving resolve phlegm effect in the side.
Herba Pileae Scriptae: have good heat-clearing and toxic substances removing antiinflammation, the upper respiratory tract common pathogen is had the good restraining effect, and do not find tangible pathogenic bacterium drug resistance, in the side, play cough-relieving, antiinflammation.
Fructus rhois chinensis: its Main Ingredients and Appearance is the Fructus rhois chinensis total flavones, and it also can alleviate bronchial muscular spasm except that having clear and definite antibacterial and anti-inflammation functions, play the antiinflammatory antiasthmatic effect in the side.
Traditional antitussive on the market, as Chinese medicine fritillary-loquat syrup, Fructus Momordicae syrup, cough with asthma spirit, shake bile-fritillary oral liquid, Western medicine brown mixture, promethazine syrup, and fast-selling antitussive on the market in recent years, as anticol, pendant madam syrup, magical cough-relieving syrup or the like, they all are simple relieving cough and resolving phlegm medicine, and do not have antiinflammatory, the function of relievining asthma.
Purpose of the present invention is exactly in order to overcome above-mentioned shortcoming, disclose a kind ofly be used for the treatment of cough-relieving, reduce phlegm, antiinflammatory relievings asthma, senile acute and chronic bronchitic compound Rhododendron seniavinii granule and preparation method thereof particularly.
Technical scheme of the present invention is finished like this: the composition and the percentage by weight thereof of compound Rhododendron seniavinii granule are as follows:
Rhododendron seniavinii 1500-5000g optimal dose 3000g 50%
Herba Pileae Scriptae 500-1667g optimal dose 1000g 16.7%
Fructus rhois chinensis 1000-3333g optimal dose 2000g 33.3%
The preparation method of compound Rhododendron seniavinii granule is as follows: get white spirit all over the mountain and recruit 31.25 kilograms of sheets, 20.83 kilograms of Fructus rhois chinensiss, 10.41 kilograms of Herba Pileae Scriptaes, decoct filtration in 5 hours, recrement adds an amount of decoction of water 3 hours again, twice filtrate merges, concentrate about 11 liters of cream, add 52 kilograms of 95% ethanol, stir, temperature is bathed half an hour and is filtered, the filtrate recovered alcohol is to alcohol-free flavor, approximately 1.2 kilograms of thick shape mastic things, then get 240 kilograms of the thick shape mastic of Rhododendron seniavinii things → boil sterilize 1 hour → reduce to 50 ℃ → add 120 kg dextrin → dust → dry and pulverize → add an amount of dextrin granulation → oven dry → spray Mentholum liquid → granule packing.
The present invention has the following advantages: three herbal medicines tie in the side, complement each other, integrate cough-relieving, reduce phlegm, antiinflammatory, relieving asthma, its clinically evident in efficacy, particularly treat difficult miscellaneous diseases---senile acute and chronic bronchitis, and have no side effect, these characteristics of we are that other antitussives are too far behind to catch up; This prescription is prepared into the granule dosage form to be particularly suitable for old people, child and diabetics and to take.
Fig. 1 is total effects index dynamic change figure of the present invention.
Fig. 2 is for the present invention coughs, expectorant, breathe heavily therapeutic index dynamic change figure.
1 expression expectorant among the figure, 2 expressions are breathed heavily, and 3 expressions are coughed.
One, medication and observational technique
" compound Rhododendron seniavinii " is made up of Rhododendron seniavinii, Herba Pileae Scriptae, three kinds of medicines of Fructus rhois chinensis.
Rhododendron seniavinii: Cuculidae plant net year shrub.Be born in the hilly country, open spring and spend in vain.
Herba Pileae Scriptae: Chloranthaceae, Herba Pileae Scriptae belongs to.Evergreen undershrub.Be born in the sough in trench limit, gully, the density woods.
Fructus rhois chinensis: Anacardiaceae, Rhus.Shrub or dungarunga.Be born in the hilly country, hillside.
Therapeutic Method: clothes once with granule one bag 5g, are taken after mixing it with water with boiled water one cuvette at every turn for each person every day.Every day or drug delivery are every other day called, and ten days is a course of treatment.
Observational technique: the case of receiving treatment, through detailed inquiring about disease history, physical examination and fluoroscopy of chest are carried out strictness and are selected.Case diagnosis, typing and pathology are judged the unified standard of all drafting by the whole nation, make before treatment.The treatment beginning, the patient that makes a house call that every other day visits observes the state of an illness and changes, and makes itemized record, and the patient is in treatment, and work, work and life are as usual.After finished complete ten days courses of treatment, the state of an illness changed by the standard rating curative effect before and after contrast was taken medicine.Two, general analysis of clinical
1. sex: count male 186 examples, women 117 examples.
2. age: 50~59 years old person's 179 example, 50~69 years old person's 108 example, 16 examples more than 70 years old.Maximum age person 79 years old.
3. the course of disease: 1~5 year person's 46 example, 6~10 years person's 97 examples, 11~20 years person's 37 examples, 21~30 years person's 16 examples, 7 examples more than 30 years.
4. the state of an illness: by sick type simple type 241 examples, the type of panting 62 examples.By slight person's 42 examples of state of an illness weight, moderate person's 134 examples, severe person's 127 examples.(1) clinical observation on the therapeutic effect
20 days curative effect of table 1 treatment
Control in the recent period | Produce effects | Take a turn for the better | Invalid | Add up to | Effectively routine (%) | Produce effects example (%) | ||
Simple type | Gently | 11 | ?12 | ?3 | ?1 | ?27 | 26 | 23 |
In | 28 | ?53 | ?25 | ?5 | ?111 | 106 | 81 | |
Heavy | 25 | ?48 | ?36 | ?7 | ?116 | 109 | 73 | |
Subtotal | 64 | ?113 | ?64 | ?13 | ?254 | 241 (94.88) | 177(69.68) | |
The type of panting | Gently | 1 | ?2 | ?1 | ?0 | ?4 | 4 | 3 |
In | 1 | ?17 | ?10 | ?0 | ?28 | 28 | 18 | |
Heavy | 1 | ?11 | ?4 | ?1 | ?17 | 16 | 12 | |
| 3 | ?30 | ?15 | ?1 | ?49 | 48(97.96) | 33(67.35) | |
Amount to | 67 | ?143 | ?79 | ?14 | ?303 | 289 (95.38) | 210(69.31) |
Ten days curative effect of table 2 treatment
Control in the recent period | Produce effects | Take a turn for the better | Invalid | Add up to | Effectively routine (%) | Produce effects example (%) | ||
Simple type | Gently | 5 | ?11 | ?9 | ?2 | ?27 | 24 | 16 |
In | 7 | ?41 | ?50 | ?13 | ?111 | 96 | 48 | |
Heavy | 9 | ?39 | ?53 | ?15 | ?116 | 97 | 48 | |
Subtotal | 21 | ?91 | ?112 | ?30 | ?254 | 224 (88.19) | 112(44.09) | |
The type of panting | Gently | 0 | ?2 | ?2 | ?0 | ?4 | 4 | 2 |
In | 1 | ?7 | ?18 | ?2 | ?28 | 26 | 8 | |
Heavy | 0 | ?3 | ?12 | ?2 | ?17 | 15 | 3 | |
Subtotal | 1 | ?12 | ?32 | ?4 | ?49 | 45(91.84) | 13(26.53) | |
Amount to | 22 | ?103 | ?144 | ?34 | ?303 | 269 (88.78) | 125(41.25) |
A. in 22 examples of former closely this control of treatment in ten days, treatment had 16 routine efficacy consolidations to 20 days, kept control in the recent period, and 5 examples are reduced to produce effects, and 1 example is reduced to improvement.
B. be in 103 examples of produce effects originally, and had 40 examples to be upgraded to recent control through continuing treatment, 51 examples keep produce effects, and 12 examples are reduced to improvement.
C. be in 144 examples that take a turn for the better originally, and had 11 examples to be upgraded to recent control through continuing treatment, 77 examples are upgraded to produce effects, and 51 examples keep taking a turn for the better, and it is invalid that 5 examples are reduced to.
D. be in invalid 34 examples originally, and had 10 examples to be upgraded to produce effects through continuing treatment, 15 examples are upgraded to improvement, and 9 examples are still invalid.
In the degradation case, 1 example is reduced to improvement by recent control, and the agnogenio before this produce effects of reducing to continues and reduces to improvement because of suffering from cold.Reduce to produce effects, produce effects by recent control and reduce to improvement, take a turn for the better and reduce in the 22 invalid examples, 13 examples are because of the flu of suffering from cold, and 6 is routine agnogenio, and 3 is routine because of eating Plantula Brassicae chinensis, green pepper, vinegar.
(2) cough, expectorant, breathe heavily the individual event curative effect
Have according to 303 examples cough, expectorant and 49 examples have the analysis of cases of breathing heavily: cough, expectorant, 20 days curative effects of breathing heavily three kinds of symptoms all obviously improved than ten days, effective percentage rises to 94.06%, 95.05%, 91.84% from 86.78%, 86.13%, 73.47% respectively; Obvious effective rate 46.53%, 47.85%, 26.53% rises to 71.61%, 75.57%, 57.14% (all learn by statistics and handle: P<0.01, difference highly significant) respectively.From the individual event of symptom relatively, cough, the expectorant curative effect is close, breathes heavily then relatively poor.(table 3)
Table 3 treatment 20 days to cough, expectorant, the curative effect of breathing heavily
Control in the recent period | Produce effects | Take a turn for the better | Invalid | Add up to | Effectively routine (%) | Produce effects example (%) | ||
Cough | Ten days | 25 | ?116 | ?122 | ?40 | ?303 | 263 (86.78) | 141(46.53) |
20 days | 70 | ?147 | ?68 | ?18 | ?303 | 285 (94.06) | 271(71.61) | |
Expectorant | Ten days | 36 | ?109 | ?116 | ?42 | ?303 | 261 (86.13) | 145(47.85) |
20 days | 81 | ?148 | ?59 | ?15 | ?303 | 288 (95.05) | 229(75.57) | |
Breathe heavily | Ten | 3 | ?10 | ?23 | ?13 | ?49 | 36(73.47) | 13(26.53) |
20 days | 5 | ?23 | ?17 | ?4 | ?49 | 45(91.84) | 28(57.14) |
Curative effect was dynamic in (3) two ten days
Dynamic for the curative effect of observing in 20 days, we are added up the every other day observed and recorded respectively, and use the therapeutic index method, so that comparison and observation are dynamically.
(a) it is dynamic to observe 20 days curative effects with the therapeutic index method, and at first as can be seen, though many cases occur repeatedly, curative effect goes down, and with regard to 303 examples in general, curative effect is constantly to rise, and up to 20 days, still has and continues the trend that rises.Next is that curative effect rises rapidly before eight days, six days effectively reach 77.21%, with four days in onset 246 examples are arranged, consistent with 86.04%.Be that rising in 12 days is the slowest once more, match at most with the 12 multiple cases of mentioning later.(Fig. 1, table 4)
(b) cough, expectorant, rising situation and total pathological changes feelings dynamically consistent that breathe heavily three symptom therapeutic index.Cough, expectorant is close, breathes heavily then to rise slowlyer, four days therapeutic equivalences breathing heavily are coughed, two days levels of expectorant, ten days suitable six days levels.(Fig. 2, table 5, table 6, table 7)
The every other day curative effect that table 7 is breathed heavily changes
(4) situation repeatedly
In whole therapeutic process, there are 81 examples to occur repeatedly, curative effect goes down.81 examples simple type 75 examples of falling into a trap, the type of panting 6 examples.
(a) number of occurrence: 71 examples once repeatedly, 8 examples of secondary, three times 2 examples, totally 81 examples, 93 times repeatedly.
(b) reason repeatedly: 65 times of the flu of suffering from cold, 18 times of unknown cause, other eat Plantula Brassicae chinensis, Fructus Cucurbitae moschatae, Radix Pachyrhizi Erosi, Fructus Colocasiae Esculentae, Fructus Capsici, vinegar, drink, contact cold water etc. 10 times.
(c) reciprocal time: with 12 days routine repeatedly numbers served as at most, counted 22 examples, dynamic observed with curative effect to match.(table 8)
Table 8 is example time dynamic table repeatedly
The treatment | 2 | ?4 | ?6 | ?8 | ?10 | ?12 | ?14 | ?16 | ?18 | ?20 |
Example is inferior repeatedly | 0 | ?1 | ?5 | ?9 | ?8 | ?22 | ?8 | ?16 | ?15 | ?9 |
(d) degradation situation repeatedly: because of falling once 80 times repeatedly, fall secondary 13 times.(table 9)
Table 9 is the degradation situation statistical table repeatedly
Degradation situation | Control-improvement | Produce effects-invalid | Control-produce effects | Produce effects-improvement | Take a turn for the better-invalid |
Number of | 2 | 11 | 17 | 29 | 34 |
(e) recovery situation: recover to be meant that curative effect returns to repeatedly preceding level.Come to an end 20 day course of treatment, do not return to repeatedly not listing in of preceding level as yet and recover.Amount to having 62 times of having recovered, do not recover to have 31 times (table 10).Unrecovered majority still remains on effect level, and only 6 examples are final invalid because of reducing to repeatedly.
Table 10 recovery situation statistics
Distance is natural law repeatedly | 2 | ?4 | ?6 | ?8 | ?10 | 12 | 14 | Add up to |
Recovered number of times | 32 | ?18 | ?6 | ?3 | ?2 | 0 | 1 | 62 |
Do not recover number of | 12 | ?11 | ?3 | ?2 | ?1 | 0 | 2 | 31 |
(5) invalid analysis of cases
Through 20 days treatment, last 14 invalid examples, 20 days effective case meter 8 examples never wherein, simple type severe 4 examples in 8 examples (wherein 1 routine concurrent emphysema), simple type moderate 3 examples (wherein 1 routine concurrent lung is swollen), concurrent emphysema 1 example of the type of panting severe.From the course of disease: 1 example more than 20 years, 2 examples more than 10 years, 4 examples more than 5 years, 1 example in 3 years.Oldest 68 years old.Each 4 example of sex men and women.In addition have 5 examples to reach improvement in the time of ten days in 6 examples, back ten days 3 examples because of flu, 2 examples are agnogenio reduce to finally invalid.1 example has reached produce effects at six days, reduce to invalidly because of flu in the time of eight days, takes a turn for the better again to 16 days through treatment, reduces to invalidly because of flu again, and fails to recover to 20 days in 18 days.
What be worth to propose is that the invalid all the time case of 21 examples was arranged when ten day course of treatment, through continuing treatment, except that 8 examples still be invalid, surplus that 7 examples rise to produce effects in 13 examples, 6 examples are upgraded to improvement.So to invalid all the time case, necessary extending the period of treatment.
(6) pulmonary function test
We have selected 30 routine patients in the Da Feng township, make three kinds of pulmonary function tests commonly used before beginning to take medicine and when finished the course of treatment in 20 day, compare, and vital capacity, 1 second timed vital capacity change little, maximal voluntary ventilation and then change obviously as a result.Variation before and after three kinds of pulmonary function treatments of (table 11) table 11
Vital capacity (milliliter) mean+SD | Maximal voluntary ventilation (litre/minute) mean+SD | 1 second timed vital capacity (milliliter) mean+SD | |
Before the treatment | 1964±97 | 30.1±2.1 | 1508±107 |
After the treatment | 2055±113 | 37.8±2.5 | 1555±125 |
(a) vital capacity: changes little before and after the treatment, also indistinction between the different curative effects.This is because vital capacity is a kind of deep breathing tolerance, and is irrelevant with speed of breathing and time, even under normal circumstances, also have ± fluctuation about in the of 20%,, can also expel residual gas simultaneously, often be difficult for the truth that reaction gas connects amount if giving when more catch cropping exhales deeply.(table 12)
The variation of vital capacity (mean+SD) (milliliter) before and after table 12 treatment
Recent control+produce effects | Take a turn for the better | |
Before the treatment | 1835±124 | 2200±135 |
After the treatment | 1910±137 | 2290±217 |
(b) 1 second timed vital capacity: similarly change not quite before and after the treatment, do not see difference between the different curative effects.Because the normal value of 1 second timed vital capacity is 84% of a vital capacity, very big standard deviation was arranged in normal range, it is generally acknowledged that 1 second timed vital capacity as being not less than 60% of vital capacity, had not both had clinical meaning, be 77% before the treatment of this group, lost clinical meaning.(table 13)
The variation of vital capacity (meansigma methods soil standard deviation) (milliliter) before and after 1 second before and after table 13 treatment)
Recent control+produce effects | Take a turn for the better | |
Before the treatment | 1315±120 | 1766±181 |
After the treatment | 1425±156 | 1788±162 |
(c) maximal voluntary ventilation: because maximal voluntary ventilation is a ventilation measured when breathing with maximal rate and amplitude within a certain period of time, the function that can more comprehensively reflect lung, thus maximal voluntary ventilation for trachea, whether unobstructed bronchus is is than important index.Before and after the treatment of this group case, having 30.1 ± 2.1 (liters/minute) to rise to 37.8 ± 2.5 (liters/minute) differs above two standard deviations, existing statistically remarkable meaning illustrates the pulmonary insufficiency that chronic tracheitis causes owing to sputum obstruction trachea, bronchus, the existing improvement after treating.The case of selecting when doing maximal voluntary ventilation and other pulmonary functions, meter be control 6 examples in the recent period, remarkable 11 examples, and 13 examples that take a turn for the better, 1 example is invalid.Very few for fear of routine number, inconvenience relatively will be controlled in the recent period with produce effects two and make up also, and reject invalid 1 example.Comparative result: the ventilatory function change of different curative effects there is no obvious difference.(table 14)
The variation of maximal voluntary ventilation (mean+SD) before and after table 14 treatment (liter/minute))
Recent control+produce effects | Take a turn for the better | |
Before the treatment | 28.2±2.9 | 33.2±2.9 |
After the treatment | 35.2±2.7 | 40.1±6.5 |
(7) Electrocardioscopy
Treat preceding 18 examples and accept Electrocardioscopy.Meter normal ECG 6 examples, sinus bradycardia 7 examples, low-voltage 2 examples, early jump and right bundle conduction block 1 example in the room, and chamber property is early jumped and right ventricular hypertrophy 1 example, old left side wall myocardial infarction and coronary insufficiency 1 example.Electrocardiogram check when finished the course of treatment in 20 day, 3 routine sinus bradycardias are recovered normal heart beating, and 1 routine chamber property is early jumped disappearance, and 1 routine coronary insufficiency has clear improvement, surplus no change.
(8) numeration of leukocyte
Check 128 examples altogether, find no after the treatment improve.(table 15)
The variation of numeration of leukocyte before and after table 15 treatment
Three, model case
Numeration of leukocyte | <4000 | 4000-8000 | >8000 |
Before the treatment | 59 | 66 | 3 |
After the treatment | 69 | 57 | 2 |
Example one, Chen Famu, man, 73 years old, Nanping City's nursing house.
Example two, Tang Shuidang, man, 52 years old, the water depressed place workman of WANGTAI group of Nanping City's WANGTAI people's commune.
Cough, breathe heavily year surplus in the of 30, suffer from cold and promptly send out, the Winter-Spring aggravation.Apasm of coughing round the clock before the treatment, the abundant expectoration color is white, and activity is then panted and is increased the weight of slightly, and the influence work is experienced: the medium heavy breathing of two lungs toot sound and moist rale.Chest X-rays two enhanced lung markings.Diagnose the type chronic tracheitis of panting.Took medicine second day, because of the cold cough aggravation, general aching, asthma increases the weight of.Continue to the 8th day, cough, expectorant, breathe heavily just to get better and change three one-tenth.Continue to take medicine to fortnight, cough, the complete obiteration of expectoration symptom, asthma obviously alleviates, and climbing is only felt gas and is sprained.Finish 20 day course of treatment, expectorant, cough, breathe heavily and all reach clinic control, roar toot sound and moist rale of pulmonary disappears.Four, discuss
(1) about curative effect
This is organized 303 examples and observes through 20 days treatment, and the effective percentage of total state of an illness is 95.38%, and obvious effective rate is 69.31%, and this group patient takes medicine observing time in the first arrival in October by the end of October, day cyclostrophic cold.According to patient's reflection, former years to this season, every multiple work of tracheitis.Therefore patient's nature favorable factor can be got rid of.Can think efficient medicine in view of the above.
From onset time, meter 261 examples of onset account for 86.03% in four days, and this value and 234 examples were arranged effectively in six days accounts for 77.23% consistent.Six days effective cases are described, most onsets in four days.Thereby find out that this medicine is more quick-acting.But, also has improved necessity as active remedy.In view of both non-toxic reaction after existing dosage form, the dosage dispensing, side effect is extremely slight (and only finding xerostomia is arranged, tinnitus, dizziness after 3 examples are taken medicine in ten days) again, many patients are counter to see that appetite increases, and is easy to fall asleep, and therefore can consider on existing basis, suitably escalated dose might be quickened onset.
This medicine to cough, expectorant, the effect of breathing heavily is all more satisfied, the three compares, and breathes heavily then relatively poorly, treats 20 days threes' effective percentage and obvious effective rate respectively with 95.05%, 94.06%, 91.84% and 75.57%, 71.61%, 57.14%.
From the individual event symptom therapeutic index curve of Fig. 2, cough with expectorant and disappear, whether illustrate that the curative effect of coughing is because the influence of expectorant, expectorant subtracts and coughs gently, expectorant have and coughs breath? should be analyzed.We no doubt find expectorant from case, cough take effect simultaneously or expectorant to cough the person that then do not take effect earlier more, but have 24 routine expectorant still invalid and cough and take a turn for the better, illustrate that this medicine also has antitussive action preferably.
From coughing, expectorant, breathe heavily that to find out the therapeutic index dynamic change figure that the curative effect of breathing heavily occurs slower, four days curative effects are close to be coughed, two days levels of expectorant, close six days levels of ten days curative effects.Illustrating may be owing to coughs, after expectorant takes a turn for the better, breathes heavily promptly and take a turn for the better thereupon.This point is panted and is had that 19 examples are coughed earlier, the expectorant several years among the type patient, there is the appearance of breathing heavily the side, as if mention evidence, the proof cough, expectorant and breathe heavily between dependence, many appearance that case is coughed for a long time, expectorant causes, breathe heavily after the treatment with cough, expectorant good then take a turn for the better, but can not therefore illustrate that this medicine does not just have antiasthmatic effect.Because 9 routine patients are arranged, in when beginning treatment, breathe heavily and take a turn for the better, and cough, expectorant is invalid.Therefore the effect of this medicine to breathing heavily, because of cough, the antiasthmatic effect of expectorant influence and medicine itself the two have concurrently, but that the antiasthmatic effect of medicine occurs is slower, must accumulate potentiation and arrive to a certain degree, can obviously occur.
(2) about curative effect
Observation contrast according to 20 days illustrates that the curative effect that extends the period of treatment to improving this medicine is necessary.Reason is:
(a) 20 days curative effects improve obviously than ten days curative effects, and effective percentage and obvious effective rate bring up to 95.38% and 69.31% from 88.78% and 41.25% respectively.Therapeutic index rises day by day, and is still on the rise to 20 days, if continue to extend the period of treatment, might further improve curative effect.
(b) 21 cases that do not occur curative effect all the time in ten day course of treatment, treatment are to 20 days, except that 8 examples do not take effect yet, surplus that 7 examples are upgraded to produce effects in 13 examples, and 6 examples are upgraded to improvement.Therefore extend the period of treatment, can make part " stubbornness " state of an illness obtain the course of treatment.
(c) it is slower to find out that from the therapeutic index of individual event symptom the curative effect of breathing heavily occurs, but through after extending the period of treatment, significantly improve the course of treatment, effective percentage 73.47% from ten day course of treatment, bring up to 20 days 91.84%, obvious effective rate then brings up to 57.14% from 26.53%, and proving extends the period of treatment can further improve curative effect to breathing heavily.May be because the antiasthmatic effect of medicine itself need be accumulated potentiation.
(3) about reaching invalid case repeatedly
In the whole therapeutic process, there are 81 examples to occur repeatedly, the curative effect degradation, the end ten day course of treatment of 46 examples to two does not recover the preceding repeatedly level of arrival, and wherein 6 examples are invalid at last, directly influence effective percentage.Though 40 examples are still effective, the program that affects the treatment degree.
From total state of an illness therapeutic index performance graph, therapeutic index rose the slowest at 12 days, with 12 days repeatedly case match at most, illustrate that also case directly affects the treatment repeatedly.
About occurring repeatedly, majority is to suffer from cold due to flu or the raw and cold diet, all belongs to extraneous factor.Some invalid case there is no the exopathogenic factor influence, but still invalid: though some has the exopathogenic factor influence, do not see appearance repeatedly, the immanent cause that patient is described is the principal element that affects the treatment.Therefore, the long-acting problem of discussion medicine can not singly be set about from medicine, must prevent to suffer from cold flu to adapt to extraneous variation, to cooperate in conjunction with the resistance against diseases that improves patient's body, reaches and avoids repeatedly, improves curative effect.Five, brief summary
(1) compound Rhododendron seniavinii granule therapy 303 routine senile chronic tracheitiies are evident in efficacy 20 day course of treatment, effective percentage 95.38%, and obvious effective rate reaches 69.31%, non-toxic reaction, side effect is slight.
(2) this medical instrument cough-relieving arranged, eliminate the phlegm, antiasthmatic effect, antiasthmatic effect is worse than cough-relieving, eliminates the phlegm.
(3) extended to 20 days from ten days the course of treatment, curative effect obviously improves, and from the therapeutic index curve, still has the continuation trend of rising in 20 days.
(4) case is more repeatedly in the treatment, affects the treatment, and analyzes reason, and the flu of suffering from cold is more, needs to improve the resistance against diseases of body, and the active prevention flu is to cooperate Drug therapy.
(5) once made pulmonary function test before and after the treatment, Electrocardioscopy and numeration of leukocyte find that treatment back maximal voluntary ventilation significantly improves, and the indivedual cases of electrocardiogram have clear improvement to deficiency myocardial blood supply, and leukocyte is not then seen change.
It seems from this group case observation that (6) escalated dose extends the period of treatment, still can improve curative effect.
Claims (5)
1. compound Rhododendron seniavinii granule, it is characterized in that: this granule is to be made by the raw material of following consumption:
Rhododendron seniavinii 1500-5000g
Herba Pileae Scriptae 500-1667g
Fructus rhois chinensis 1000-3333g
2. a kind of compound Rhododendron seniavinii granule according to claim 1 is characterized in that wherein:
Rhododendron seniavinii 3000g
Herba Pileae Scriptae 1000g
Fructus rhois chinensis 2000g
3. compound Rhododendron seniavinii granule, it is characterized in that: this granule is to be made by the raw material of the white proportion by subtraction of following its weight:
Rhododendron seniavinii 50%
Herba Pileae Scriptae 16.7%
Fructus rhois chinensis 33.3%
4. the preparation method of compound Rhododendron seniavinii granule according to claim 1 and 2 is characterized in that: get white spirit all over the mountain and recruit sheet, Fructus rhois chinensis, Herba Pileae Scriptae, decoction filtering, recrement decocts again, and filtrate merges, concentrate cream, add ethanol stirring, temperature bath filtration, recovered alcohol gets thick shape mastic thing to alcohol-free flavor, get Rhododendron seniavinii extractum and boil when sterilizing, cooling adds dextrin, dust, oven dry is pulverized, and adds an amount of dextrin and granulates, oven dry, spray Mentholum liquid, granule packing.
5. the preparation method of a kind of compound Rhododendron seniavinii granule according to claim 4 is characterized in that: 31.25 kilograms of described white spirit trick sheets all over the mountain, 20.83 kilograms of Fructus rhois chinensiss, 10.41 kilograms of Herba Pileae Scriptaes decoct filtration in 5 hours, and recrement adds an amount of decoction of water 3 hours again, twice filtrate merges, concentrate about 11 liters of cream, add 52 kilograms of 95% ethanol, stir, temperature is bathed half an hour and is filtered, the filtrate recovered alcohol is to alcohol-free flavor, approximately 1.2 kilograms of thick shape mastic things, then get 240 kilograms of the thick shape mastic of Rhododendron seniavinii things, boil sterilization 1 hour, reduce to 50 ℃, add the 120 kg dextrin, dust, oven dry is pulverized, adding an amount of dextrin granulates, oven dry, spray Mentholum liquid, granule packing.
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CN99124960A CN1105572C (en) | 1999-12-29 | 1999-12-29 | Compound rhododendron senivainii granule and its preparing method |
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CN99124960A CN1105572C (en) | 1999-12-29 | 1999-12-29 | Compound rhododendron senivainii granule and its preparing method |
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CN1105572C true CN1105572C (en) | 2003-04-16 |
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CN105055792A (en) * | 2015-08-16 | 2015-11-18 | 李静静 | Traditional Chinese medicine composition for treating phlegm-damp chronic bronchitis |
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CN1079659A (en) * | 1993-01-01 | 1993-12-22 | 福建省建瓯制药厂 | Seniavin rhododendron root cough suppressing medicine and preparation process thereof |
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CN1079659A (en) * | 1993-01-01 | 1993-12-22 | 福建省建瓯制药厂 | Seniavin rhododendron root cough suppressing medicine and preparation process thereof |
Non-Patent Citations (1)
Title |
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《首都医药》1998,5(9) 1998-10-01 华泽英,"复方满山白的临床引用" * |
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