CN110553096B - Programmable micro-valve device and method for controlling micro-fluid transportation by using same - Google Patents
Programmable micro-valve device and method for controlling micro-fluid transportation by using same Download PDFInfo
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- CN110553096B CN110553096B CN201910801713.0A CN201910801713A CN110553096B CN 110553096 B CN110553096 B CN 110553096B CN 201910801713 A CN201910801713 A CN 201910801713A CN 110553096 B CN110553096 B CN 110553096B
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- 239000012530 fluid Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims abstract description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 50
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 50
- 229920000642 polymer Polymers 0.000 claims abstract description 48
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims abstract 17
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims abstract 17
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims abstract 17
- 238000004458 analytical method Methods 0.000 description 12
- 229920000747 poly(lactic acid) Polymers 0.000 description 9
- 239000004626 polylactic acid Substances 0.000 description 9
- 238000005206 flow analysis Methods 0.000 description 7
- NMWSKOLWZZWHPL-UHFFFAOYSA-N 3-chlorobiphenyl Chemical compound ClC1=CC=CC(C=2C=CC=CC=2)=C1 NMWSKOLWZZWHPL-UHFFFAOYSA-N 0.000 description 5
- 101001082832 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Pyruvate carboxylase 2 Proteins 0.000 description 5
- LAXBNTIAOJWAOP-UHFFFAOYSA-N 2-chlorobiphenyl Chemical compound ClC1=CC=CC=C1C1=CC=CC=C1 LAXBNTIAOJWAOP-UHFFFAOYSA-N 0.000 description 4
- 101710149812 Pyruvate carboxylase 1 Proteins 0.000 description 4
- 238000012742 biochemical analysis Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 230000005686 electrostatic field Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 polydimethylsiloxane Polymers 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
- F16K99/0026—Valves using channel deformation
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0034—Operating means specially adapted for microvalves
Abstract
The invention discloses a programmable micro valve device and a method for controlling micro fluid transportation by using the same, wherein the programmable micro valve device comprises a lower PCB, an upper PCB, a self-locking button and a micro fluid transportation part, wherein the central area of the lower PCB penetrates through the upper and lower surfaces to form a lower hollow area, the central area of the upper PCB penetrates through the upper and lower surfaces to form an upper hollow area, a movable part of the self-locking button is positioned in the lower hollow area, a fixed foot of the self-locking button is arranged on the lower PCB, the micro fluid transportation part consists of a PDMS polymer which is flatly filled in the upper hollow area and a micro channel which is arranged in the PDMS polymer, an inlet and an outlet which are communicated with the micro channel are formed on the upper surface of the PDMS polymer, and the movable part of the self-locking button is tightly attached to the lower surface of the PDMS polymer in a self-locking state after the upper PCB is flatly and tightly stacked on the lower PCB; the advantage is simple structure, easily integrates, and does not have the phenomenon that micro fluid leaked when the micro valve was opened.
Description
Technical Field
The invention relates to a technology for controlling micro-fluid transportation in a micro-fluidic chip, in particular to a programmable micro-valve device and a method for controlling micro-fluid transportation by using the same.
Background
The microfluidic analytical system has the advantages of small volume, high analysis speed, small amount of reagents consumed by analysis and the like, so the microfluidic analytical system is favored by experts and scholars in various fields, becomes increasingly a research hotspot in the field of biochemical analysis, has been widely applied to the fields of DNA analysis, cell analysis, protein analysis, drug detection, environmental monitoring, food safety and the like, and has the invention and the application of a microfluidic device with a new structure.
In the process of carrying out microfluidic analysis in a microfluidic analysis system, control of the flow direction of a microfluidic is a precondition for biochemical analysis of the microfluidic. The control of the flow direction of the microfluid is realized by means of a micro valve in the microfluidic analytical system, which is an indispensable constituent unit of the microfluidic analytical system operating in a continuous flow mode. The micro-valves can be divided into active micro-valves and passive micro-valves according to whether the control mode of the micro-valves needs an external power source. The active micro valve requires an external power source to drive the micro valve to act so as to change the flowing direction of the micro fluid in the micro channel, thereby controlling the transportation of the micro fluid in the micro channel. Passive microvalves do not require an external power source, and only need to change the microchannel surface characteristics or design specific microchannel geometries within the microchannel to control the flow direction of the microfluid. Compared with an active micro valve, a passive micro valve has the advantages of small geometric dimension and easiness in integration, but the passive micro valve is complex in structure, has the defects of needing surface treatment and the like on the interior of a micro channel, and is difficult to operate micro fluid to reversely transport, so that the controllability of the passive micro valve on micro fluid control is weak, and meanwhile, the opening and closing operation time of the passive micro valve is relatively long, and the passive micro valve has a certain limitation.
To solve the disadvantages of passive micro-valves, active micro-valves have been developed and active micro-valve structures with different external power sources have been derived. The external power sources which are applied more and relatively commonly for the active micro-valve mainly comprise pneumatic, electromotive, electrochemical potential, static electricity, electromagnetism, phase change, a thermal expansion valve, a mixed source of the external power sources and the like. The micro valve constructed by the external power source has the characteristics and advantages of the manner of controlling the micro fluid in the micro fluid analysis system, and meanwhile, has the defects of controlling the micro fluid performance caused by the specific driving characteristics. For example, the pneumatic micro valve constructed by taking the pneumatic as an external power source has the advantages that the manufacturing process of the micro valve is simpler, the structure of the micro valve is also simple, but the greatest disadvantage is that an air pump and a control circuit for controlling the air pump are additionally arranged, so that the pneumatic micro valve has larger volume, and the air pump cannot be integrated with a micro channel in a micro flow analysis system and is not matched with the development target of micro flow analysis, thereby greatly counteracting the small-size advantage of the micro flow analysis system. For another example, the electrostatic micro valve constructed by using static electricity as external power source is characterized by that it deposits and photo-etching two electrodes on the micro-flow substrate, and applies voltage on the electrodes to produce electrostatic field, and utilizes the change of electrostatic field to control flow and direction of micro-fluid, so that it has the advantages of easy integration of micro-valve, but its self-characteristics, i.e. after the electrode is powered up, it can easily electrolyze working fluid in micro-channel to affect micro-flow analysis, so that its application is limited. For example, the thermal expansion micro valve constructed according to the principle controls the flow direction of the micro fluid, and has the advantages of simple structure, no need of externally connecting a large-volume air pump, relatively small overall size of the thermal expansion micro valve, and the disadvantage of long switching time of the micro valve due to the fact that the micro valve needs to be switched according to the rising and falling of the temperature of the thermal expansion material. Other micro valves constructed by several external power sources have advantages and disadvantages and are applied to corresponding specific occasions.
The programmable micro valve can be used for determining the opening and closing time of the micro valve according to the micro flow analysis requirement and the requirement of an operator on an analysis site, and has practical significance on micro flow analysis with low analysis cost on the site. As journal Sensors and Actuators A, physical (sensor and actuator) volume 265, 9 th page 224-230, A versatile plug microvalve for microfluidic applications (a multifunctional plug microvalve for microfluidic applications) discloses a field programmable microvalve, in which a hole is drilled in a cylindrical polylactic acid rod by a 200 ℃ hot air gun, the cylindrical polylactic acid rod with the hole is inserted into a polydimethylsiloxane microchannel, the inserted cylindrical polylactic acid rod is at the same level as the microchannel, and the cylindrical polylactic acid rod is manually rotated so that when the hole in the cylindrical polylactic acid rod is in the same direction as the microchannel, the microfluid can pass through the microchannel, and the microvalve is opened; the cylindrical polylactic acid rod is rotated for 90 degrees, the holes in the cylindrical polylactic acid rod cannot be connected with a micro-channel, microfluid cannot be transported in the micro-channel, and the micro-valve is closed. Compared with the active micro valve, the programmable micro valve has the advantages that the manufacturing process is simple, the micro valve can be manufactured only by a heat gun and drilling equipment, meanwhile, the programmable micro valve is easy to integrate a micro-flow analysis system without additional air pumps, heat sources and other off-chip devices, however, the programmable micro valve needs to ensure that the holes in the cylindrical polylactic acid rod and the micro channel holes are strictly at the same height when being manufactured, so that when the micro valve is opened, micro fluid in the micro channel can pass through the holes in the cylindrical polylactic acid rod and reach the other side of the micro channel, and therefore, the risk of micro fluid leakage when the micro valve is opened exists, and the micro valve needs to be improved.
Disclosure of Invention
The invention aims to provide a programmable micro-valve device and a method for controlling micro-fluid transportation by using the same, wherein the programmable micro-valve device has a simple structure, is easy to integrate, and has no micro-fluid leakage phenomenon when a micro-valve is opened.
The technical scheme adopted for solving the technical problems is as follows: a programmable microvalve device, characterized by: the micro-fluidic transmission part consists of a PDMS polymer which is flatly filled in the upper hollow area and a micro-channel which is arranged in the PDMS polymer, wherein an inlet and an outlet which are communicated with the micro-channel are formed in the upper surface of the PDMS polymer, the upper PCB is flatly and tightly stacked on the lower PCB, and then the movable part of the self-locking button is tightly attached to the lower surface of the PDMS polymer in a self-locking state; the movable part of the self-locking button pushes the PDMS polymer upwards in an opening state to deform the PDMS polymer upwards, so that the micro-channel is blocked, and the programmable micro-valve device is closed; the PDMS polymer is in a flat state under the self-locking state of the movable part of the self-locking button, and the micro-channel is smooth, so that the programmable micro-valve device is opened.
Two slide plates are arranged on the upper surface of the upper PCB plate in parallel across the PDMS polymer, the movable part of the self-locking button is positioned in the middle of the two slide plates in space, the end parts of the slide plates are fixedly connected with the upper surface of the upper PCB plate, and the middle parts of the slide plates are in contact with the upper surface of the PDMS polymer. By arranging the two slide plates, the movable part of the self-locking button only upwards pushes a part of the PDMS polymer positioned between the two slide plates in an open state, so that the micro-channel can be blocked better; and the ends of the two slide plates are fixedly connected with the upper surface of the upper PCB, so that the PDMS polymer is also protected.
The end part of the slide is adhered to the upper surface of the upper PCB.
The distance between the movable part of the self-locking button and the slide is 2-3 mm. The distances defined herein are determined by a number of experiments.
The upper hollow-out area is a cuboid hollow-out area.
A method of controlling microfluidic transport using the programmable microvalve device described above, comprising the steps of:
step one: feeding the microfluid through an inlet of a microchannel;
step two: in the initial state of the programmable micro-valve, the movable part of the self-locking button is in a self-locking state, the PDMS polymer is in a flat state, the micro-channel is smooth, and the micro-fluid is normally transported through the micro-channel; if the programmable micro valve is required to be closed, the movable part of the self-locking button is pressed once to enable the movable part of the self-locking button to be in an open state, and at the moment, the movable part of the self-locking button upwards pushes the PDMS polymer to enable the PDMS polymer to deform upwards, so that the micro channel is blocked, and the micro fluid cannot be normally transported through the micro channel; if the programmable micro valve is required to be opened, the movable part of the self-locking button is pressed again, so that the movable part of the self-locking button is in a self-locking state, at the moment, the PDMS polymer is restored to a flat state, the micro channel is smooth, and the micro fluid is normally transported through the micro channel.
Compared with the prior art, the invention has the advantages that:
1) Through setting up down PCB board and last PCB board, and set up the movable part of auto-lock button in the hollow area of PCB board down, set up the PDMS polymer of taking the microchannel in the hollow area of last PCB board, utilize the movable part of auto-lock button to open the time to upwards push up the PDMS polymer and make the microchannel blocked and can realize the closure of this programmable micro valve device like this, not only simple structure is easily integrated moreover.
2) The programmable micro-valve device does not need to butt joint the micro-channel on the premise of meeting the field operation, only changes the deformation of the micro-channel, and avoids the damage of the micro-valve operation part to the integrity of the micro-channel, thereby fundamentally solving the problem that micro-fluid is likely to leak when the micro-valve is operated.
3) In a microfluidic analytical system comprising a plurality of programmable microvalve devices, the programmable microvalve devices can program the state of the microvalves according to microfluidic analysis to complete microfluidic flow control and achieve microfluidic analysis.
Drawings
Fig. 1 is an exploded view of a programmable microvalve device of the present invention.
Detailed Description
The invention is described in further detail below with reference to the embodiments of the drawings.
Embodiment one:
the programmable micro-valve device provided by the embodiment is shown in the figure, the programmable micro-valve device comprises a lower PCB 1, an upper PCB 2, a self-locking button 3 and a micro-fluid conveying part 4, wherein the central area of the lower PCB 1 penetrates through the upper and lower surfaces to form a lower hollowed-out area 11, the central area of the upper PCB 2 penetrates through the upper and lower surfaces to form an upper hollowed-out area 21, the upper hollowed-out area 21 is a cuboid hollowed-out area, a movable part 31 of the self-locking button 3 is positioned in the lower hollowed-out area 11, a fixed foot 32 of the self-locking button 3 is arranged on the lower PCB 1 in a welding mode, the micro-fluid conveying part 4 consists of a PDMS (polydimethylsiloxane) polymer 41 flatly filled in the upper hollowed-out area 21 and a micro-channel 42 arranged in the PDMS polymer 41, an inlet 421 and an outlet 422 communicated with the micro-channel 42 are formed in the upper surface of the PDMS polymer 41, and the movable part 31 of the self-locking button 3 is flatly and tightly stacked on the lower PCB 1 in a tightly-locking state; the movable part 31 of the self-locking button 3 pushes up the PDMS polymer 41 in an open state, so that the PDMS polymer 41 is deformed upwards, and the micro-channel 42 is blocked, and the programmable micro-valve device is closed; the PDMS polymer 41 is in a flat state under the self-locking state of the movable part 31 of the self-locking button 3, and the micro-channel 42 is smooth, so that the programmable micro-valve device is opened.
In this embodiment, two slide plates 5 are disposed on the upper surface of the upper PCB 2 in parallel across the PDMS polymer 41, the movable part 31 of the self-locking button 3 is located in the middle of the two slide plates 5 in space, the distance between the movable part 31 of the self-locking button 3 and the slide plates 5 is 2-3 mm, the end of the slide plate 5 is fixedly connected with the upper surface of the upper PCB 2 by bonding, and the middle part of the slide plate 5 is in contact with the upper surface of the PDMS polymer 41. By arranging the two slide plates 5, the movable part 31 of the self-locking button 3 only pushes up part of the PDMS polymer 41 positioned between the two slide plates 5 in the open state, so that the micro-channel 42 can be blocked better; and since the ends of the two slide plates 5 are fixedly connected with the upper surface of the upper PCB 2, the PDMS polymer 41 is also protected.
In this embodiment, the self-locking button 3 is a commercially available self-locking button having a movable part and a fixed leg.
Embodiment two:
the present embodiment provides a method for controlling microfluidic transport using the programmable micro valve device of the first embodiment, comprising the steps of:
step one: the microfluidic is injected through the inlet 421 of the microchannel 42.
Step two: in the initial state of the programmable micro-valve, the movable part 31 of the self-locking button 3 is in a self-locking state, the PDMS polymer 41 is in a flat state, the micro-channel 42 is smooth, and the micro-fluid is normally transported through the micro-channel 42; if the programmable micro valve needs to be closed, the movable part 31 of the self-locking button 3 is pressed once, so that the movable part 31 of the self-locking button 3 is in an open state (the movable part 31 of the self-locking button 3 stretches upwards under the action of the restoring force of the spring in the movable part 31 of the self-locking button 3), at the moment, the movable part 31 of the self-locking button 3 upwards pushes against the PDMS polymer 41, so that the PDMS polymer 41 deforms upwards, the micro channel 42 is blocked, and the micro fluid cannot be normally transported through the micro channel 42; if the programmable micro valve needs to be opened, the movable part 31 of the self-locking button 3 is pressed again, so that the movable part 31 of the self-locking button 3 is in a self-locking state (the spring in the movable part 31 of the self-locking button 3 is contracted), at the moment, the PDMS polymer 41 is restored to a flat state and the micro channel 42 is unblocked, and the micro fluid is normally transported through the micro channel 42.
Claims (4)
1. A programmable microvalve device, characterized by: the self-locking device comprises a lower PCB, an upper PCB, a self-locking button and a microfluid conveying part, wherein the central area of the lower PCB penetrates through the upper surface and the lower surface to form a lower hollow area, the central area of the upper PCB penetrates through the upper surface and the lower surface to form an upper hollow area, the upper hollow area is a cuboid hollow area, a movable part of the self-locking button is positioned in the lower hollow area, a fixed foot of the self-locking button is arranged on the lower PCB, the microfluid conveying part consists of a PDMS polymer which is flatly filled in the upper hollow area and a microchannel which is arranged in the PDMS polymer, an inlet and an outlet which are communicated with the microchannel are formed in the upper surface of the PDMS polymer, two slide plates are arranged on the upper surface of the upper PCB in parallel, a movable part of the self-locking button is positioned in the middle of the two slide plates in space, the end part of the self-locking button is flatly filled in the PDMS polymer in the upper hollow area, and the upper surface of the PDMS polymer is in close contact with the lower surface of the lower PCB, and the upper surface of the PDMS polymer is in close contact with the lower surface of the self-locking button; the movable part of the self-locking button pushes the PDMS polymer upwards in an opening state to deform the PDMS polymer upwards, so that the micro-channel is blocked, and the programmable micro-valve device is closed; the PDMS polymer is in a flat state under the self-locking state of the movable part of the self-locking button, and the micro-channel is smooth, so that the programmable micro-valve device is opened.
2. A programmable microvalve device according to claim 1, wherein: the end part of the slide is adhered to the upper surface of the upper PCB.
3. A programmable microvalve device according to claim 1 or 2, wherein: the distance between the movable part of the self-locking button and the slide is 2-3 mm.
4. A method of controlling microfluidic transport using the programmable microvalve device of claim 3, comprising the steps of:
step one: feeding the microfluid through an inlet of a microchannel;
step two: in the initial state of the programmable micro-valve, the movable part of the self-locking button is in a self-locking state, the PDMS polymer is in a flat state, the micro-channel is smooth, and the micro-fluid is normally transported through the micro-channel; if the programmable micro valve is required to be closed, the movable part of the self-locking button is pressed once to enable the movable part of the self-locking button to be in an open state, and at the moment, the movable part of the self-locking button upwards pushes the PDMS polymer to enable the PDMS polymer to deform upwards, so that the micro channel is blocked, and the micro fluid cannot be normally transported through the micro channel; if the programmable micro valve is required to be opened, the movable part of the self-locking button is pressed again, so that the movable part of the self-locking button is in a self-locking state, at the moment, the PDMS polymer is restored to a flat state, the micro channel is smooth, and the micro fluid is normally transported through the micro channel.
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| CN110985693B (en) * | 2019-12-13 | 2021-06-25 | 大连海事大学 | Portable programmable parallel fluid control flat plate extrusion micro-valve device |
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| CN104180015A (en) * | 2014-07-07 | 2014-12-03 | 宁波大学 | Micro valve and method for controlling transport of fluid by virtue of micro valve |
| CN106732836A (en) * | 2016-12-08 | 2017-05-31 | 宁波大学 | Micro-valve and its control method that a kind of surface acoustic wave control is opened and closed |
| CN206637105U (en) * | 2017-04-06 | 2017-11-14 | 青岛意诚融智生物仪器有限公司 | A kind of electromagnetic micro valve for micro-fluidic chip |
| CN108443579A (en) * | 2018-04-11 | 2018-08-24 | 利多(香港)有限公司 | A kind of micro-valve and micro-fluidic chip that can control liquid flowing |
| CN210860050U (en) * | 2019-08-28 | 2020-06-26 | 武夷学院 | Programmable micro valve device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004062923A1 (en) * | 2004-12-28 | 2006-07-06 | Hirschmann Laborgeräte GmbH & Co. KG | Device for conveying fluids, method for producing the same and pipette with such a device |
| US20110236277A1 (en) * | 2010-03-24 | 2011-09-29 | Electronics And Telecommunications Research Institute | Microfluid control device and method of manufacturing the same |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104180015A (en) * | 2014-07-07 | 2014-12-03 | 宁波大学 | Micro valve and method for controlling transport of fluid by virtue of micro valve |
| CN106732836A (en) * | 2016-12-08 | 2017-05-31 | 宁波大学 | Micro-valve and its control method that a kind of surface acoustic wave control is opened and closed |
| CN206637105U (en) * | 2017-04-06 | 2017-11-14 | 青岛意诚融智生物仪器有限公司 | A kind of electromagnetic micro valve for micro-fluidic chip |
| CN108443579A (en) * | 2018-04-11 | 2018-08-24 | 利多(香港)有限公司 | A kind of micro-valve and micro-fluidic chip that can control liquid flowing |
| CN210860050U (en) * | 2019-08-28 | 2020-06-26 | 武夷学院 | Programmable micro valve device |
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