CN110545825A

CN110545825A - Disinfecting composition

Info

Publication number: CN110545825A
Application number: CN201880019987.8A
Authority: CN
Inventors: 山田耕太郎; 樱井英知; 柴田知佳; 稻见浩之
Original assignee: Zeria Pharmaceutical Co Ltd; Osaka Pharmaceutical Co Ltd
Current assignee: Zeria Pharmaceutical Co Ltd; Osaka Pharmaceutical Co Ltd
Priority date: 2017-03-22
Filing date: 2018-03-15
Publication date: 2019-12-06
Also published as: KR20190126135A; KR20230086819A; WO2018173917A1; TWI771388B; JP6830629B2; JP2018158890A; TW201836619A

Abstract

The present invention addresses the problem of providing a disinfectant composition which is a disinfectant used for sterilization of fingers and the like, has improved moisture retention properties by incorporating chondroitin sulfate or chondroitin sulfate as a moisturizing agent, prevents hand roughness which causes invasion of bacteria and viruses and infection, and has chondroitin sulfate or chondroitin sulfate uniformly present in the composition. This can be solved by the following, etc.: a composition for disinfection, characterized by comprising 20 to 60 wt% of a lower alcohol having 1 to 3 carbon atoms, 40 to 65 wt% of water, and 0.006 to 1 wt% of chondroitin sulfate or chondroitin sulfate; and a composition for disinfection, characterized by containing an oil component, a thickener, and a surfactant, and having a viscosity of 50 to 300 pas at 25 ℃.

Description

Disinfecting composition

Technical Field

The present invention relates to a disinfectant composition which is a disinfectant used for sterilization of fingers and the like and has excellent moisture retention and properties.

Background

Conventionally, it has been generally known that lower alcohols having 1 to 3 carbon atoms such as ethanol and isopropyl alcohol have a disinfecting effect on bacteria and viruses by breaking cell membranes of bacteria and virus envelopes and coagulating proteins such as enzymes, and disinfectants containing these lower alcohols have been widely used. However, in general, a disinfectant containing a lower alcohol such as ethanol or isopropyl alcohol has a problem of causing a user's hand to be rough when used for disinfecting a finger, for example. The rough hand refers to a state in which the stratum corneum and the sebum membrane are removed, the stratum corneum is broken, and the barrier function of the skin is lost, and it can be said that bacteria and viruses are likely to invade from the barrier defect portion, and the skin is easily infected. Accordingly, a disinfectant excellent in moisture retention, which can prevent hand roughness, i.e., a loss of skin barrier function, even when a lower alcohol is blended, has been desired.

For example, patent document 1 discloses a disinfectant containing a carboxyvinyl polymer, a natural polysaccharide, and the like, a fatty acid ester, and a lower alcohol, wherein the lower alcohol is contained in an amount of 20 to 50 wt%. The finger rubbing pad is characterized in that a carboxyvinyl polymer as a tackifier is added to prevent wrinkles (ヨレ) which are caused by the salt of the finger and cause the polymer component to precipitate (resinate) on the finger, and a natural polysaccharide or a derivative thereof is added to prevent the wrinkles.

Documents of the prior art

Patent document

Patent document 1: japanese patent laid-open No. 10-130173.

Disclosure of Invention

Problems to be solved by the invention

However, the compositions described in the examples of patent document 1 have a problem of insufficient moisture retention.

In addition, the invention described in patent document 1 suggests that sodium chondroitin sulfate is used as a natural polysaccharide, but actually, if sodium chondroitin sulfate is added, there is a problem that the composition cannot be uniformly mixed because of the balance of other components in the composition, such as insolubilization.

Accordingly, an object of the present invention is to provide a disinfectant composition which is a disinfectant used for sterilization of fingers and the like, has improved moisture retention by blending chondroitin sulfate or chondroitin sulfate as a humectant, prevents hand roughness which causes invasion of bacteria and viruses and infection, and has chondroitin sulfate or chondroitin sulfate uniformly present in the composition.

Means for solving the problems

[1] Specifically disclosed is a composition for disinfection, which is characterized by containing 20-60 wt% of a lower alcohol having 1-3 carbon atoms, 40-65 wt% of water, and 0.006-1 wt% of chondroitin sulfate or chondroitin sulfate.

[2] The composition for disinfection according to the above [1], which contains an oil component, a thickener, and a surfactant, and has a viscosity of 50 to 300Pa · s at 25 ℃.

[3] The composition for disinfection according to the above [1] or [2], wherein the thickener is at least one selected from the group consisting of carboxyvinyl polymers and cellulose derivatives.

[4] The composition for disinfection according to any one of the above [1] to [3], wherein the surfactant contains a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol.

[5] The composition for disinfection according to any one of the above [1] to [4], which contains at least one disinfecting component selected from the group consisting of benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone-iodine, isopropylmethylphenol, and chloroxylenol.

ADVANTAGEOUS EFFECTS OF INVENTION

According to the present invention, a composition for disinfection is a disinfectant used for sterilization of fingers and the like, and chondroitin sulfate or chondroitin sulfate is added as a humectant to improve moisture retention, thereby preventing hand roughness which causes invasion of bacteria and viruses and infection and allowing chondroitin sulfate or chondroitin sulfate to uniformly exist in the composition.

Detailed Description

Hereinafter, embodiments of the disinfecting composition of the present invention will be described in detail. When there is an expression indicating a range in the description, the upper limit and the lower limit are included.

The lower alcohol having 1 to 3 carbon atoms in the present invention is an alcohol having 1 to 3 carbon atoms such as methanol, ethanol, isopropanol, or the like. By using the lower alcohol, bacteria and viruses can be killed by the destruction of the cell membrane of the bacteria and the viral envelope and the coagulation of proteins such as enzymes, and the adverse effects on the human body such as diseases caused by the bacteria and viruses can be prevented.

The content of the lower alcohol having 1 to 3 carbon atoms in the disinfectant composition is preferably 20 to 60% by weight. If the content ratio is more than 60% by weight, the chondroitin sulfate or chondroitin sulfate cannot be uniformly dissolved or dispersed. If the content is less than 20 wt%, bacteria and viruses cannot be sufficiently sterilized, and other sterilizing components and the like need to be added to exhibit desired effects.

Chondroitin sulfate or chondroitin sulfate in the present invention is a compound in which sulfuric acid is bonded to a sugar chain having a disaccharide composed of D-gluconic acid and N-acetyl-D-galactosamine as a constituent unit, or a salt in which hydrogen of the sulfuric acid is replaced with sodium, potassium, or the like, and is blended as a humectant. By blending chondroitin sulfate or chondroitin sulfate, the composition for disinfection has good moisture retention, particularly good moisture retention over time.

The content of chondroitin sulfate or chondroitin sulfate in the disinfectant composition is preferably 0.006 to 1% by weight. When the content is within the above range, the composition can be uniformly dissolved or dispersed in the disinfecting composition, and further, the moisture retention can be maintained for a long time to prevent the hand of the user from being rough.

The grease component in the invention is liquid or solid grease at the normal temperature of 20-25 ℃. Can be matched according to the needs. When the disinfecting composition is used by emulsifying the oil or fat component, the oil or fat component spreads on the skin of fingers and the like, and evaporation of water from the skin is suppressed, whereby roughness of the hand and the like can be prevented. As the fat and oil component, any of natural products and synthetic products can be used, and as the natural products, any of fats and oils derived from plants and animals can be used.

Examples of the oil and fat component include hydrocarbons such as liquid paraffin, light liquid paraffin, squalane, etc., isopropyl palmitate, octyl palmitate, isopropyl myristate, isononyl isononanoate, medium-chain fatty acid triglycerides composed of fatty acids having 8 to 22 carbon atoms, ester oils such as glyceryl tri (caprylate/caprate), etc., and saturated monohydric alcohols such as myristyl alcohol (carbon number 14), cetyl alcohol (carbon number 16), stearyl alcohol (carbon number 18), cetearyl alcohol (a mixture of carbon numbers 16 and 18), behenyl alcohol (carbon number 22), isostearyl alcohol (carbon number 18), 2-hexyldecanol (carbon number 16), 2-octyldodecanol (carbon number 20); examples of the nondrying oil include aliphatic alcohols such as unsaturated monohydric alcohols such as oleyl alcohol (having 18 carbon atoms), soybean oil, sunflower oil, grapeseed oil, rose hip oil, sunflower oil, evening primrose seed oil, cottonseed oil, sesame oil, wheat germ oil, and almond oil, while examples of the nondrying oil include olive oil, camellia oil, castor oil, peanut oil, avocado oil, macadamia nut oil, hazelnut oil, meadowfoam seed oil, and jojoba oil, and examples of the essential oil include eucalyptus oil, peppermint oil, and roman chamomile oil (vegetable oil). These oil and fat components may be used alone in 1 kind or in combination of 2 or more kinds.

The content of the oil or fat component in the disinfecting composition is preferably 0.5 to 20 wt%, and more preferably 1.0 to 10 wt%. If the content ratio is in the above range, the user can be prevented from having rough hands or the like during use.

The thickener in the present invention is an ingredient that increases the viscosity of the disinfecting composition. Can be matched according to the needs. By using the thickener, the viscosity can be increased to bring the viscosity of the disinfecting composition to a prescribed viscosity.

As the thickener, for example, a carboxyvinyl polymer which is a crosslinking type polyacrylic acid; cellulose derivatives such as carboxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose, xanthan gum, guar gum, gum arabic, sodium alginate, propylene glycol alginate, ethyl cellulose, sodium polyacrylate, cyclodextrin and the like, and among them, a carboxyvinyl polymer and carboxymethyl cellulose are more preferable. These thickeners may be used alone in 1 kind or in combination of 2 or more kinds.

The content of the thickener in the disinfectant composition is preferably 0.1 to 10% by weight, more preferably 0.2 to 7% by weight. If the content ratio is within the above range, the viscosity can be adjusted to a desired viscosity suitable for use.

The surfactant in the present invention is a component for uniformly mixing the disinfecting composition to stabilize the cream-like state. Can be matched according to the needs. By using the surfactant, separation of lower alcohols having 1 to 3 carbon atoms and the like as components of the composition for disinfection can be prevented.

Examples of the surfactant include cationic surfactants, anionic surfactants, amphoteric surfactants, and nonionic surfactants. The cationic surfactant is a surfactant which forms a cation when dissociated in water, and is preferably, for example, an alkyltrimethylammonium salt, an alkyldimethylammonium salt, an alkylbenzyldimethylammonium salt, or the like. The alkyl group is preferably an alkyl group having 12 to 22 carbon atoms, and the counter anion is preferably a chloride ion, a hydroxide ion, a bromide ion, or the like.

The anionic surfactant is a surfactant that forms anions when dissociated in water, and is preferably, for example, a fatty acid salt, a monoalkyl sulfate, an alkyl polyoxyethylene sulfate, an alkylbenzene sulfonate, a monoalkyl phosphate, or the like. The alkyl group is preferably an alkyl group having 12 to 22 carbon atoms, and the counter cation is preferably a sodium ion, a potassium ion, a calcium ion, a magnesium ion, or the like.

The amphoteric surfactant is a surfactant having both an anionic site and a cationic site in the molecule and forming a cation, an anion, and an amphoteric surfactant of a cation and an anion depending on the pH of the solution, and is preferably an alkyl dimethyl amine oxide, an alkyl carboxybetaine, or the like. Among them, the alkyl group is preferably an alkyl group having 12 to 22 carbon atoms.

The nonionic surfactant is an active agent having a hydrophilic site where the hydrophilic portion is not ionized, and is preferably a polyoxyethylene alkyl ether such as polyoxyethylene cetyl ether or polyoxyethylene stearyl ether; polyol fatty acid esters such as glycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester; fatty acid esters of polyoxyethylene-addition polyols, fatty acid diethanolamides, and the like. Among the above nonionic surfactants, nonionic surfactants having HLB calculated by Griffin formula of 3 to 17 are more preferable. The nonionic surfactant having a polyoxyethylene skeleton may be added in an appropriate amount by changing the number of moles of oxyethylene groups added. When the nonionic surfactant has an HLB within the above range, the disinfectant composition is excellent in storage stability, and specifically, does not cause separation or the like even when time elapses, and can be kept in a cream state. These surfactants may be used alone in 1 kind or in combination of 2 or more kinds, and preferably, the surfactant having HLB of 3-6 and the surfactant having HLB of 12-17 are combined.

In addition, water is added to the disinfecting composition of the present invention. As the water, water of japanese pharmacopoeia standards is preferable, and ordinary water such as tap water, well water, and the like is preferable; purified water obtained by treating ordinary water by any one of distillation, ion exchange treatment using an ion exchange membrane, ultrafiltration treatment using an ultrafiltration membrane, or a combination thereof; sterilized purified water obtained by sterilizing purified water by heating or the like. The proportion of the water is the balance other than ethanol, chondroitin sulfate or chondroitin sulfate used in the present invention, and when a thickener, a surfactant or the like is added, the balance other than these is preferably 40 to 65% by weight, and preferably 42 to 63% by weight.

In addition, the composition for disinfection of the present invention may contain a disinfecting component as necessary. The disinfecting component is a component which is added for disinfecting bacteria, viruses and the like which cannot be disinfected fully by the lower alcohol with 1-3 carbon atoms. As the disinfecting component, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone-iodine, isopropyl methylphenol, chloroxylenol, and the like are preferable, and benzethonium chloride is more preferable. Further, these disinfecting ingredients may be used alone in 1 kind or in combination in 2 or more kinds.

The viscosity of the disinfecting composition of the present invention can be increased by adding a thickener, and the viscosity of the disinfecting composition of the present invention is preferably 50 to 300 pas, more preferably 100 to 250 pas, under a condition of 25 ℃ in a measurement using a Brookfield type rotational viscometer B model (product name "TVB-10M" manufactured by Toyobo industries Co., Ltd.) described in JIS K7117-1. If the viscosity of the disinfecting composition is in this range, the disinfecting composition does not immediately fall off even if it is attached to the skin such as fingers, and is easily spread when applied.

The disinfecting composition of the present invention may further contain a humectant other than chondroitin sulfate or chondroitin sulfate. Examples of the other moisturizers include glycerin, polyglycerol, propylene glycol, 1, 3-butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, polyethylene glycol, maltitol, and polyhydric alcohols such as sorbitol, sodium hyaluronate, urea, sodium lactate, and trimethylglycine.

In addition to the above components, an antioxidant such as tocopherol and vitamin C, BHT, a pH adjuster, a buffer, a perfume, a pigment, and the like may be added to the composition for disinfection of the present invention as needed.

Examples

[ example 1]

A composition of 30 parts by weight of ethanol, 1 part by weight of chondroitin sodium sulfate and 100 parts by weight of the balance water was prepared and mixed thoroughly to prepare a composition for disinfection.

[ example 2]

A disinfectant composition was prepared in the same manner as in example 1, except that 50 parts by weight of ethanol was used.

[ example 3]

A disinfectant composition was prepared in the same manner as in example 1, except that the content of chondroitin sodium sulfate was changed to 0.01 part by weight.

Comparative example 1

A disinfectant composition was prepared in the same manner as in example 1, except that 10 parts by weight of ethanol was used.

Comparative example 2

A disinfectant composition was prepared in the same manner as in example 1, except that 70 parts by weight of ethanol was used.

Comparative example 3

A disinfectant composition was prepared in the same manner as in example 1, except that sodium chondroitin sulfate was not added.

[ appearance Properties ]

When the properties of the composition for disinfection immediately after production were evaluated visually, the state in which the sodium chondroitin sulfate was uniformly dissolved was referred to as "a" evaluation, and the state in which the sodium chondroitin sulfate was not dissolved or was dulled due to the sodium chondroitin sulfate was referred to as "C" evaluation, and the following evaluations were performed: "A" is evaluated as preferred and "C" is evaluated as not preferred.

[ moisture retention ]

In evaluating the moisture retention of the prepared composition for disinfection, 5 panelists performed 5-stage sensory evaluation of the moisture retention after use for 1 to 5 points, and the average score was obtained, and the following evaluations were performed, distinguished based on the following evaluation criteria: "A" is evaluated as preferred, "B" and "C" are evaluated as not preferred.

A: the average value is more than 4.0

B: an average value of 2.0 or more and less than 4.0

C: the average score was less than 2.0.

[ Sterilization Effect ]

In order to evaluate the sterilization efficacy of the prepared composition for sterilization, the sample was directly contacted with the bacterial solution and applied on a plate medium, and the number of bacteria was evaluated. As evaluation criteria, the case where the ratio of the number of bacteria killed by contact with the above-mentioned disinfecting composition to the number of bacteria of the control was 99.99% or more was referred to as "a" evaluation, and the case where the ratio was less than 99.99% was referred to as "C" evaluation, and the following evaluations were performed: "A" is evaluated as preferred and "C" is evaluated as not preferred.

The results of examples 1 to 3 and comparative examples 1 to 3 concerning appearance, moisture retention and bactericidal effect are shown in Table 1.

As shown in Table 1, when sodium chondroitin sulfate was added to a composition containing ethanol and water, the moisture retention was good, but when the amount of ethanol added was 70 parts by weight, the sodium chondroitin sulfate did not dissolve, and when the amount of ethanol added was about 10 parts by weight, the bactericidal effect was not preferable. From these results, it was found that the blending ratio of ethanol, water, and sodium chondroitin sulfate needs to be in a predetermined range in order to exhibit preferable bactericidal efficacy while having good properties that sodium chondroitin sulfate is uniformly dissolved as a composition for disinfection.

[ example 4]

30 parts by weight of ethanol, 1.0 part by weight of sodium chondroitin sulfate as a humectant, 0.4 part by weight of a carboxyvinyl polymer (trade name: ハイビスワコー 103, manufactured by Wako pure chemical industries, Ltd.) as a thickener, 2 parts by weight of polyoxyethylene cetyl ether (trade name: NIKKOL BC-15, HLB: 15.5, manufactured by Sun ケミカルズ Co., Ltd.) as a nonionic surfactant, 2 parts by weight of glyceryl monostearate (trade name: NIKKOL MGS-AMV, HLB: 4.0, manufactured by Sun ケミカルズ Co., Ltd.), 1 part by weight of liquid paraffin (trade name: liquid paraffin 350S, manufactured by Centralization Co., Ltd.), 1 part by weight of isopropyl myristate as an oil component, and 0.5 part by weight of stearyl alcohol as an oil component, 0.5 part by weight of glycerin as a humectant, 0.2 part by weight of dimethylpolysiloxane (product name: "Q7-9120 SILICONE FLUID350 CST", manufactured by Tokyo レ & ダウコーニング Co., Ltd.), 0.05 part by weight of benzethonium chloride as a disinfectant component, 0.072 part by weight of sodium hydroxide, and the balance 100 parts by weight of water were thoroughly mixed to prepare a disinfectant composition.

[ example 5]

A composition for disinfection was produced in the same manner as in example 4, except that 50 parts by weight of ethanol was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 80 pas.

[ example 6]

A disinfectant composition was prepared in the same manner as in example 4, except that 0.5 part by weight of chondroitin sulfate sodium was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 95 pas.

[ example 7]

A disinfectant composition was prepared in the same manner as in example 4, except that 0.1 part by weight of chondroitin sulfate sodium was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 101 pas.

[ example 8]

A disinfectant composition was prepared in the same manner as in example 4, except that 0.01 part by weight of chondroitin sulfate sodium was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 95 pas.

Comparative example 4

A disinfectant composition was prepared in the same manner as in example 4, except that 0.01 part by weight of sodium hyaluronate was used instead of sodium chondroitin sulfate in example 4. The viscosity was measured in the same manner as in example 4, and the result was 128 pas.

Comparative example 5

A disinfectant composition was prepared in the same manner as in example 4, except that 0.05 parts by weight of carboxyvinyl polymer and 0.09 parts by weight of sodium hydroxide were used instead of the sodium chondroitin sulfate in example 4. The viscosity was measured in the same manner as in example 4, and the result was 211 pas.

Comparative example 6

A disinfectant composition was prepared in the same manner as in example 4, except that in example 4, 40 parts by weight of ethanol, 0.05 parts by weight of carboxyvinyl polymer, and 0.09 parts by weight of sodium hydroxide were used instead of sodium chondroitin sulfate. The viscosity was measured in the same manner as in example 4, and the result was 183 pas.

Comparative example 7

A composition for disinfection was produced in the same manner as in example 4, except that 70 parts by weight of ethanol was used in example 4. Moreover, separation, white turbidity, and the like were present after production, and the viscosity could not be measured in the same manner as in example 4.

Comparative example 8

A disinfectant composition was prepared in the same manner as in example 4, except that 0.005 part by weight of chondroitin sulfate sodium was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 105 pas.

Comparative example 9

A composition for disinfection was produced in the same manner as in example 4, except that 10 parts by weight of ethanol was used in example 4. The viscosity was measured in the same manner as in example 4, and the result was 185Pa · s.

[ appearance Properties ]

When the properties of the composition for disinfection immediately after production were evaluated by visual observation, the state in which the sodium chondroitin sulfate was uniformly dissolved, was creamy, and no separation was observed was evaluated as "a", the state in which the sodium chondroitin sulfate was present in a dull state but was dissolved and no separation was observed was evaluated as "B", and the state in which separation was not uniform was evaluated as "C", and the following evaluations were carried out: the "A" evaluation and the "B" evaluation are preferable, and the "C" evaluation is not preferable.

[ moisture retention ]

In evaluating the moisture retention of the prepared disinfectant composition, 5 panelists performed 5 sensory evaluations of the moisture retention after use for 1 to 5 points, and the average score was obtained and classified based on the following evaluation criteria, and the following evaluations were performed: "A" is evaluated as preferred, "B" and "C" are evaluated as not preferred.

A: the average value is more than 4.0

B: an average value of 2.0 or more and less than 4.0

C: average score less than 2.0

[ Sterilization Effect ]

In order to evaluate the sterilization efficacy of the prepared composition for sterilization, the sample was directly contacted with the bacterial solution, spread on a plate medium, and cultured, and the number of bacteria was evaluated. As evaluation criteria, the case where the ratio of the number of bacteria killed by contact with the above-mentioned disinfecting composition to the number of bacteria of the control was 99.99% or more was referred to as "a" evaluation, and the case where the ratio was less than 99.99% was referred to as "C" evaluation, and the following evaluations were performed: "A" is evaluated as preferred and "C" is evaluated as not preferred.

The results of examples 4 to 8 and comparative examples 4 to 9 concerning viscosity, appearance, moisture retention and bactericidal effect are shown in Table 2.

As is clear from table 2, in the blending system of ethanol, sodium chondroitin sulfate, a thickener, a surfactant, water, and the like, by setting the predetermined content ratio of ethanol, sodium chondroitin sulfate, and water, the cream-like properties can be stably maintained at the time of producing the disinfecting composition, and the moisture retention and the bactericidal efficacy are also good. By containing the fat component, the thickener, and the surfactant in this manner and setting the viscosity to a predetermined range, a semisolid, high-viscosity emulsion composition for disinfection can be formed which has excellent emulsion stability and can prevent hand roughness and have good moisture retention even when used, while adding a lower alcohol having 1 to 3 carbon atoms at a high proportion.

Comparative example 10

A disinfecting composition was prepared containing 78 parts by weight of ethanol, 0.4 part by weight of a carboxyvinyl polymer, 0.072 part by weight of sodium hydroxide, and the balance water.

Comparative example 11

A disinfecting composition was prepared containing 54 parts by weight of ethanol, 0.4 part by weight of a carboxyvinyl polymer, 0.072 part by weight of sodium hydroxide, and the balance water.

The amount of water evaporated was measured for the compositions for disinfection of example 8 and comparative examples 10 to 11. That is, the amount of moisture evaporated through the skin when the disinfecting compositions were applied 1 time and 10 times continuously in an environment of about 25 ℃ and 30 to 40% humidity was measured using a Tewameter TM300 (product of Courage + Khazaka corporation) 5 minutes and 10 minutes after 1 application and 5, 10, 20, and 30 minutes after 10 times continuously. Then, the amount of change was calculated from the difference between the transdermal water evaporation amount after the lapse of time and the transdermal water evaporation amount before application, and the skin barrier property of the skin was evaluated. The difference between the amount of percutaneous water evaporation after 10 minutes from the 1-time application and the 10-time continuous application, that is, the amount of change, was calculated, and the case where the amount of change was negative was evaluated as good. These results are shown in Table 3.

As is apparent from table 3, the disinfecting composition of example 8 was less in the amount of transdermal water evaporation after 10 minutes than before application after 1 application and 10 applications, and the amount of change in the amount of transdermal water evaporation after 10 minutes from the initial amount of transdermal water evaporation was negative, and was superior to comparative examples 10 to 11 in terms of skin barrier properties, because evaporation of water was suppressed. Further, by providing excellent skin barrier properties, invasion and infection of bacteria and viruses from the skin can be prevented.

Claims

1. A composition for disinfection, characterized by comprising 20 to 60 wt% of a lower alcohol having 1 to 3 carbon atoms, 40 to 65 wt% of water, and 0.006 to 1 wt% of chondroitin sulfate or chondroitin sulfate.

2. The composition for disinfection according to claim 1, comprising an oil component, a thickener, and a surfactant, and having a viscosity of 50 to 300 Pa-s at 25 ℃.

3. The composition for disinfection according to claim 1 or 2, wherein the thickener is at least one selected from the group consisting of carboxyvinyl polymers and cellulose derivatives.

4. The composition for disinfection according to any one of claims 1 to 3, wherein the surfactant comprises a polyoxyethylene alkyl ether and a fatty acid ester of a polyhydric alcohol.

5. The composition for disinfection according to any one of claims 1 to 4, characterized by containing at least one disinfection component selected from the group consisting of benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, povidone-iodine, isopropylmethylphenol, and chloroxylenol.