CN110522929A - A kind of xeothermic low pressure continuous sterilization process - Google Patents
A kind of xeothermic low pressure continuous sterilization process Download PDFInfo
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- CN110522929A CN110522929A CN201911034492.5A CN201911034492A CN110522929A CN 110522929 A CN110522929 A CN 110522929A CN 201911034492 A CN201911034492 A CN 201911034492A CN 110522929 A CN110522929 A CN 110522929A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/17—Combination with washing or cleaning means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
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Abstract
The invention belongs to material sterilization technology fields, it is related to a kind of xeothermic low pressure continuous sterilization process, sterilizing inner cavity is heated by heating device, and sterilizing inner cavity is vacuumized by vacuum plant, adjust the temperature for the inner cavity that sterilizes when setting sterilizing, an endfeed of the material from the sterilizing inner cavity of tubular type, material is conveyed from feed inlet to discharge port by conveying auger, according to the micro organism quantity of material and moisture content in sterilization process, control vacuum degree and pressure are held time, in material transportation process, positive pressure negative pressure compound action, it sterilizes under conditions of being lower than 100 DEG C, sterilization time is adjusted by adjusting the rotational speed regulation material of the conveying auger residence time in sterilizing inner cavity.The present invention combines traditional hot air sterilization mode with preset positive/negative-pressure, and the physical sterilization technique of no any bactericidal agent works under relatively low temperature conditions, keeps the pharmacological property of material, and realize continuous sterilization.
Description
Technical field
The invention belongs to material sterilization technology fields, and in particular to a kind of xeothermic low pressure continuous sterilization process.
Background technique
Sterilizing (Steri1ization) refers to the microorganism remaining appropriate that will either physically or chemically pollute in material
Probability drops to certain level, makes up to requirement.In 2015 editions " Chinese Pharmacopoeia " the one 459 kinds of preparations recorded, containing primary
The kind of medicinal powder is up to 343 kinds, accounts for the 74.73% of preparation total amount, and the microbial limit of the powder preparation containing crude drug in whole is higher than other systems
As many as 10~100 times of agent, how much the primary medicinal powder of the Chinese medicine either prepared slices of Chinese crude drugs have seriously affected preparation, final product quality containing bacterium.
7023rd article of regulation in " drug GMP certification inspection evaluation mark "；" medicinal powder being directly used as medicine should do microorganism before ingredient
Check ", Chinese drugs powder meets microbial limit requesting party and can be used as medicine.Oral preparation of Chinese traditional medicinal microbial limit containing crude drug powder
Standard: aerobic bacteria sum cfu/g and yeast and mold sum cfu/g is respectively pill: 3.0 × 104, 1.0 × 102；Tablet and
Capsule: 1.0 × 104, 1.0 × 102.Therefore, before in the primary medicinal powder of Chinese medicine, either the prepared slices of Chinese crude drugs are used as medicine, to microbial limit
The primary medicinal powder of the exceeded Chinese medicine either prepared slices of Chinese crude drugs have to sterilize using suitable sterilization method.
Common sterilizing methods have: moist hear heat test, hot-air sterilization, cobalt -60(60Co)-γ irradiation sterilization method, ethyl alcohol are low
Warm sterilization, ethylene oxide sterilizing method, ozone sterilization method, ultraviolet sterilization, microwave sterilization method, retorted method, leaching
Steep sterilization etc..But all have the defects that certain.If microwave sterilization service condition is less, there are equipment costs greatly, safety wind
The problems such as danger, technique close rule；60It is Co irradiation sterilization price, at high cost, there are stringent dose of radiation requirement and kind specification, advises
Determine dosage and be unable to reach sterilizing requirement, it is necessary to which (prescribed dose is generally 5Kgy- kilogray, practical for super 200-800% dosage use
It is just effective to reach 40-50Kgy- kilogray), foreign countries have disabled；Ethyl alcohol low temperature sterilization, ethylene oxide sterilizing method, ozone go out
Bacterium method, immersion sterilization will introduce bactericidal agent or other substances.
Moist heat sterilization refers to the method to be sterilized with saturated steam, boiling water or flowing steam to material, method sterilizing
Ability is strong, is one of most effective, most widely used sterilizing methods in heat sterilization, is the most frequently used in pharmaceutical preparation production process
Sterilizing methods.According to the difference of temperature and pressure, moist heat sterilization is divided into high pressure steam sterilization, flowing steam sterilization, low temperature again
Discontinuous sterilization etc..Different moist heat sterilization method sterilization effects is different, but its sterilized principle for germ is all the egg made in microbial cells
White matter, nucleic acid etc. deform solidification cause its death.Moist heat sterilization is especially the most frequently used with autoclaving, generallys use
121 DEG C of sterilizings, 15~20min or 115 DEG C of sterilizing bis- kinds of technological parameter of 30min.Moist hear heat test can be used for solid, semisolid
With the sterilizing of liquid preparation.The shortcomings that moist heat sterilization is: 1, temperature high (121 DEG C) is very big to Chinese medicine component damage, thermal sensitivity
Ingredient decline, volatile aromatic ingredient heavy losses, and many product compositions are unable to reach test stone；2, change pharmacological property:
Life medicinal material in prescriptions of traditional Chinese medicine becomes maturity medicinal material, and some curative effects have played the opposite effect, and Chinese medicine processing loses completely
Effect, if the Radix Rehmanniae of White Phoenix Bolus of Black-bone Chicken accounts for 1/2, radix rehmanniae preparata accounts for 1/2, become radix rehmanniae preparata entirely in this way, radix rehmanniae recen clearing heat and cooling blood and master rush down,
Rehmannia glutinosa then nourishing yin and supplementing blood and main benefit, the raw rhubarb of antiphlogistic bezoar pellet, become prepared RADIX ET RHIZOMA RHEI after sterilizing, curative effect is opposite etc.；3,
Separating twice is needed, easy to pollute, loss of material 1.5-2%；4, energy consumption is high.
Hot-air sterilization is to kill the technology of bacterium and bacterial spore with high temperature in dry environments, generally " 115 DEG C,
Based on 90min ".Its sterilized principle for germ is made in protein oxidation, denaturation, carbonization and electrolyte concentration by the way that high temperature dehydration is dry
Poison makes microbial inactivation.Suitable for the sterilizing of Chinese drugs powder, low moisture medicinal extract, effect is aobvious at 110~120 DEG C of sterilising temp
It writes, herbal pharmaceutical enterprise carries out hot air sterilization operation frequently with tunnel type hot air sterilization.The shortcomings that hot-air sterilization, is: 1, temperature
High (115 DEG C) are very big to Chinese medicine component damage, heat-sensitive ingredients decline, volatile aromatic ingredient heavy losses, and very much
Product composition is unable to reach test stone；2, change pharmacological property: the life medicinal material in prescriptions of traditional Chinese medicine becomes maturity medicinal material, some treatments
Effect has played the opposite effect, and Chinese medicine processing loses effect completely, and if the Radix Rehmanniae of White Phoenix Bolus of Black-bone Chicken accounts for 1/2, radix rehmanniae preparata accounts for 1/2, this
Sample becomes radix rehmanniae preparata entirely, radix rehmanniae recen clearing heat and cooling blood and master rush down, Rehmannia glutinosa then nourishing yin and supplementing blood and main benefit, the life of antiphlogistic bezoar pellet are big
Huang, becomes prepared RADIX ET RHIZOMA RHEI after sterilizing, curative effect is opposite etc.；3, contain volatile oil component, chaff or the high fine medicinal material powder of lubricant component ratio,
Be not suitable for using hot-air sterilization, 4, energy consumption height.
Therefore, existing hot-air sterilization, moist hear heat test presence may destroy ingredient, lessen the curative effect, change pharmacological property
Problem, cobalt -60(60Co)-γ irradiation sterilization method, ethyl alcohol low temperature sterilization, ethylene oxide sterilizing method, ozone sterilization method, ultraviolet light
Sterilization, microwave sterilization method, retorted method, immersion sterilization presence may change ingredient, generate toxicity, change character
The problems such as.
Summary of the invention
In order to overcome hot-air sterilization very big to Chinese medicine component damage, heat-sensitive ingredients decline changes pharmacological property, is unsuitable for
Containing volatile oil component, chaff or the high medicinal material disadvantage of lubricant component ratio, and traditional hot-air sterilization can not achieve dynamic into
Material, dischargingization continuous sterilization, the invention proposes a kind of xeothermic low pressure continuous sterilization process, by traditional hot air sterilization mode and
Preset positive/negative-pressure combination, the physical sterilization technique of no any bactericidal agent work under relatively low temperature conditions, keep material
Pharmacological property, and realize continuous sterilization.
The present invention is realized by following technical proposals.A kind of xeothermic low pressure continuous sterilization process, passes through heating device pair
Sterilizing inner cavity is heated, and is vacuumized by vacuum plant to sterilizing inner cavity, sterilizing inner cavity when adjusting setting sterilizing
Material is conveyed from feed inlet to discharge port by conveying auger, is gone out from an endfeed of the sterilizing inner cavity of tubular type by temperature, material
According to the micro organism quantity and moisture content of material during bacterium, holding time for negative-pressure vacuum degree and positive pressure pressure, material are controlled
In transmission process, positive pressure negative pressure compound action sterilizes under conditions of being lower than 100 DEG C, by the revolving speed tune for adjusting conveying auger
Section material residence time in sterilizing inner cavity adjusts sterilization time.
Because the microorganism in material is under vacuum and pressure alternating state, cell wall gap changes and supports with thickness
Imperial external environment ability decline, (- 0.09Mpa~-0.095Mpa, the evaporating temperature of water is about for intracellular water flash distillation when high vacuum
48~36 DEG C), cell wall expands rapidly even explosion inactivation；Cell wall resistance declines under low vacuum and low-pressure state, makes
The tolerable temperature of cell wall reduces, the deactivation under low-heat (90~98 DEG C) environment, thus reach the sterilizing in low-heat, so
Sterilising temp is 90~98 DEG C, and 0~-0.095Mpa of vacuum degree, 0~0.08Mpa of pressure is preferred.
It is preferred that can be passed through steam in sterilization process in the sterilizing drum jacket outside sterilizing inner cavity and carry out heated material, adopt
It heats in this way, homogeneous heating, easy control of temperature.Certainly poor mode can also be heated using Electric heating
Sterilize inner cavity, but this mode is easy to cause heating uneven, influences sterilization effect or material of burning.
It is preferred that conveying auger be it is hollow, interior logical steam is come the heating to material realized, conveying auger is not only
Play the role of conveying stirring, also act as heat effect, keeps material heating more uniform.
It is preferred that adjusting the sterilization time of material, specific root by controlling the revolving speed of conveying auger in sterilization process
It is determined according to the type and feature of material.
It is preferred that after material can also be delivered to sterilizing inner cavity, pause conveying auger works or slows down in sterilization process
Conveying auger revolving speed makes material 60~150min(of heat-insulation pressure keeping sterilizing, 60~150min in sterilizing inner cavity) to reach enough
Sterilization time, the material after being then then exhausted from sterilizing.
Preferably, xeothermic low pressure continuous sterilizer of the present invention includes several grades of sterilization cylinders, sterilizings at different levels
Intracavitary in the sterilizing of cylinder to be equipped with conveying auger and the heating device for heat sterilization cylinder, it is true that sterilization cylinders at different levels are equipped with connection
The vacuum port of empty device, the feed inlet of chopped-off head sterilization cylinder are connected with feeding device, and the discharge port connection of every level-one sterilization cylinder is next
The feed inlet of grade sterilization cylinder, the discharge port of final stage sterilization cylinder are equipped with outlet valve and connect receiving hopper.
Preferably, the heating device includes sterilizing drum jacket for heating in sterilization cylinder cylinder, each sterilization cylinder
Sterilizing drum jacket is sequentially communicated, and the sterilizing drum jacket of chopped-off head sterilization cylinder sets steam inlet, and the sterilizing drum jacket of final stage sterilization cylinder is set
Condensation-water drain.
Preferably, the conveying auger is made of hollow shaft and the hollow ribbon blade being looped around on hollow shaft.
Preferably, sterilization cylinders at different levels are equipped with the Butterworth Hatch for cleaning.
Preferably, the conveying auger of sterilization cylinders at different levels is connected by transmission mechanism, driven by same power mechanism.
Technical effect of the invention:
1, traditional hot air sterilization mode is combined with preset positive/negative-pressure, the physical sterilization technique without any bactericidal agent, sterilising temp
Low (90~98 DEG C), sterilization rate breach the technical problem in sterilizing field up to 99.5% or more；
2, sterilising temp is lower than 100 DEG C, and the loss of ethereal oil substance is few, keeps raw material color constant；
3, holding material (medicinal material) is raw, ripe after processing, pharmacological property is constant, retains volatility, temperature-sensitive sexual element to greatest extent；
4, compared with dry and wet heat sterilization: sterilising temp declines 30~80 DEG C, avoids separating twice, secondary pollution, significantly saving energy
Source, material yield improve 1.5~2%, reduce sterilizing cost 80%；
5, continous way, yield are big, occupied area is small, realize the functions such as automatic feed/discharge, automatic cleaning, automatic uniform mixing, fit
Collaborate waterline.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of xeothermic low pressure continuous sterilization in the present invention.
In figure: 1- feed hopper, 2- inlet valve, 3- sterilization cylinder shell, 4- sterilization cylinder insulating layer, 5- Butterworth Hatch, 6- sterilization cylinder
Collet, 7- vacuum port filter core, 8- hollow shaft, the hollow ribbon blade of 9-, 10- sterilizing inner cavity, 11- first order sterilization cylinder, 12- second
Grade sterilization cylinder, 13- third level sterilization cylinder, 14- outlet valve, 15- receiving hopper, 16- speed reducer, N1- feed inlet, the first vacuum of N2a-
Mouth, the second vacuum port of N2b-, N2c- third vacuum port, N3- steam inlet, N4- condensation-water drain, P1- first pressure gauge mouth,
P2- second pressure gauge mouth, P3- third gauge port, the first thermometer of T1- mouth, T2- second temperature table mouth, T3- third thermometer
Mouth, the first Butterworth Hatch of M1-, the second Butterworth Hatch of M2-, M3- third Butterworth Hatch, the 4th Butterworth Hatch of M4-, the 5th Butterworth Hatch of M5-, M6-
6th Butterworth Hatch, the 7th Butterworth Hatch of M7-.
Specific embodiment
For ease of understanding, the present invention is further clarified with reference to the accompanying drawings and examples.
A kind of xeothermic low pressure continuous sterilization process of the invention carries out sterilizing inner cavity by heating device before charging
Heating, and sterilizing inner cavity is vacuumized by vacuum plant, the temperature for set inner cavity that sterilizes when sterilizing is adjusted as 90~98
DEG C, material is conveyed material from feed inlet to discharge port by conveying auger, material from an endfeed of the sterilizing inner cavity of tubular type
It is heated sterilizing in transmission process, according to the micro organism quantity and moisture content of material in sterilization process, controls vacuum and pressure.Cause
It is the microorganism in material under vacuum and pressure alternating state, cell wall gap and thickness change and resist external environment
Ability decline, intracellular water flash distillation (- 0.09Mpa~-0.095Mpa, about 48~36 DEG C of the evaporating temperature of water) when high vacuum,
Cell wall expands rapidly even explosion inactivation；Cell wall resistance declines under low vacuum and low-pressure state, makes the resistance to of cell wall
It is reduced by temperature, the deactivation under low-heat (90~98 DEG C) environment, to reach the sterilizing in low-heat, so sterilising temp is
90~98 DEG C, 0~-0.095Mpa of vacuum degree, 0~0.08Mpa of pressure is preferred.
In sterilization process, steam can be passed through in the sterilizing drum jacket outside sterilizing inner cavity and carry out heated material, using this side
Formula heating, homogeneous heating, easy control of temperature.Certainly poor mode can also be using Electric heating come in heat sterilization
Chamber, but this mode is easy to cause heating uneven, influences sterilization effect or material of burning.
It is preferred that conveying auger be it is hollow, interior logical steam is come the heating to material realized, conveying auger is not only
Play the role of conveying stirring, also act as heat effect, keeps material heating more uniform.
In sterilization process, the sterilization time of material is adjusted by controlling the revolving speed of conveying auger, with specific reference to material
Type and feature determine.
In sterilization process, after material can also be delivered to sterilizing inner cavity, suspends conveying auger work or slow down conveying auger
Revolving speed, make material sterilize inner cavity in 60~150min(of heat-insulation pressure keeping sterilize 60~150min) to reach enough sterilizings when
Between, the material after being then then exhausted from sterilizing.
Embodiment 1
In order to meet the process requirement of xeothermic low pressure continuous sterilization, the present invention devises xeothermic low pressure as shown in Figure 1 and continuously goes out
Bacterium device, but sterilization process implementation of the invention is not limited to xeothermic low pressure continuous sterilizer shown in FIG. 1.
Xeothermic low pressure continuous sterilizer includes three sterilization cylinders of long tubular, and feed hopper 1, receiving hopper 15 etc. each go out
Bacterium cylinder all includes sterilization cylinder shell 3, sterilization cylinder insulating layer 4, sterilizing drum jacket 6, sterilizing inner cavity 10, and sterilization cylinder shell 3 is located at most
Outer layer, innermost layer be sterilizing inner cavity 10, sterilizing 10 outsourcing of inner cavity sterilize drum jacket 6, sterilizing drum jacket 6 and sterilization cylinder shell 3 it
Between setting sterilization cylinder insulating layer 4 with rise an insulation effect, sterilizing drum jacket 6 be used for heat sterilization cylinder, sterilizing inner cavity 10 in setting it is defeated
Auger is sent, conveying auger is made of hollow shaft 8 and the hollow ribbon blade 9 being looped around on hollow shaft 8, and hollow shaft 8 connects steam
Pipeline, by steam heated transportation auger can also material in heat sterilization cylinder, heating method can choose sterilizing drum jacket 6 or
One of conveying auger is passed through steam heating, and certainly, preferably the two heats together, and heating is more uniform.
Three sterilization cylinders are respectively first order sterilization cylinder 11, second level sterilization cylinder 12, third level sterilization cylinder 13, and the first order is gone out
11 front end of bacterium cylinder (front end referred to herein, rear end determine that feed end is front end, and discharge end is rear end by material conveying direction, under
It is equipped with inlet valve 2 together) and connects feed hopper 1, feed hopper 1 is equipped with feed inlet N1, and the discharge port of 11 rear end of first order sterilization cylinder is just
To the feed inlet of second level sterilization cylinder 12, and the charging of the discharge port of 11 rear end of first order sterilization cylinder and second level sterilization cylinder 12
Mouth is connected directly；The feed inlet of the discharge port face third level sterilization cylinder 13 of second level sterilization cylinder 12, and second level sterilization cylinder
The feed inlet of 12 discharge port and third level sterilization cylinder 13 is connected directly.Outlet valve 14 is arranged in the discharge port of third level sterilization cylinder 13
And receiving hopper 15 is connected, as shown in Figure 1, being three-level, adjacent sterilization cylinder conveying direction phase sterilization cylinder to reduce occupied area
Instead.Three-level sterilization cylinder is used in the present embodiment, certainly according to usage and performance and place needs, can also use second level,
Or even only level-one sterilization cylinder, it is very long to will lead to equipment so certainly, naturally it is also possible to it is level Four, Pyatyi or more, this
It should belong within protection scope of the present invention.
The sterilizing drum jacket 6 of 11 second level sterilization cylinder 12 of first order sterilization cylinder and third level sterilization cylinder 13 successively head and the tail phase
Even, guarantee that the direction of motion of steam is consistent with the conveying direction of conveying auger (material), the sterilizing of 11 front end of first order sterilization cylinder
Drum jacket 6 is equipped with steam inlet N3, and the sterilizing drum jacket 6 of 13 rear end of third level sterilization cylinder is equipped with condensation-water drain N4, guarantees
It is passed through steam from the feed end of device, excludes condensed water and residual steam from the discharge end of device.
During heat sterilization, the moisture of material evaporates, in order to keep low pressure, so vacuum plant should also be arranged to take out
From the steam in sterilizing inner cavity 10, therefore, first order sterilization cylinder 11 is equipped with the first vacuum port N2a, and second level sterilization cylinder 12 is equipped with
Second vacuum port N2b, third level sterilization cylinder 13 are equipped with third vacuum port N2c, and each vacuum port is equipped with vacuum port filter core 7, each true
It eats dishes without rice or wine to connect vacuum plant.
In order to improve sterilizing efficiency and guarantee safety, it should be monitored to the temperature and pressure of each sterilization cylinder.Therefore,
Level-one sterilization cylinder 11 is equipped with first pressure gauge mouth P1, and second level sterilization cylinder 12 is equipped with second pressure gauge mouth P2, third level sterilization cylinder
13 are equipped with third gauge port P3, and the rear portion that each sterilization cylinder is arranged in each gauge port is preferred, and 11 rear end of first order sterilization cylinder is set
The first thermometer mouth T1 is set, second temperature table mouth T2, the setting of 13 rear end of third level sterilization cylinder is arranged in sterilization cylinder 12 rear end in the second level
Third thermometer mouth T3, each thermometer mouth installation temperature measuring apparatus is for measuring the temperature after the sterilization cylinder sterilizing-drying.
When having dried material and carrying out material switching, or when deactivating for a long time, equipment should be cleaned, for convenience of clear
It washes, the first Butterworth Hatch M1 and the second Butterworth Hatch M2 is arranged in first order sterilization cylinder 11, and third Butterworth Hatch is arranged in second level sterilization cylinder 12
The 5th Butterworth Hatch M5, the 6th Butterworth Hatch M6, the 7th Butterworth Hatch M7 is arranged in M3 and the 4th Butterworth Hatch M4, third level sterilization cylinder 13, respectively
The Butterworth Hatch quantity of sterilization cylinder should determine that cylinder is longer, and quantity is more according to barrel lenght.
First order sterilization cylinder 11, second level sterilization cylinder 12, third level sterilization cylinder 13 conveying auger pass through driving mechanism drive
Dynamic, conveying auger one end of first order sterilization cylinder 11 is equipped with gear, which passes through the conveying of chain and second level sterilization cylinder 12
One of gear connection on auger, another gear on the conveying auger of second level sterilization cylinder 12 by another chain with
Gear connection on the conveying auger of third level sterilization cylinder 13, the conveying auger of third level sterilization cylinder 13 connect speed reducer 16, subtract
Fast machine 16 connects variable-frequency motor.Each conveying auger is driven by a speed reducer 16 jointly after being connected by gear with chain, can
Guarantee that each conveying auger revolving speed is synchronous, simplifies equipment.Certainly, poor embodiment, each conveying auger respectively can also be connected individually
Respective speed reducer.
In use, material enters first order sterilization cylinder 11 by feed inlet N1, feed hopper 1 and inlet valve 2, pass through conveying auger
It is advanced to 11 rear end of first order sterilization cylinder and falls into second level sterilization cylinder 12, then after being advanced to second level sterilization cylinder 12 by conveying auger
End falls into third level sterilization cylinder 13, and material is advanced to outlet valve 14, gone out through discharge port by the conveying auger of third level sterilization cylinder 13
Material controls the fltting speed of conveying auger, the time needed for meeting sterilizing is realized continuous by controlling 16 revolving speed of variable-frequency motor
Formula sterilizing.Temperature and the flow of steam are adjusted to adjust temperature according to the temperature of monitoring, and vacuum holding is adjusted according to institute's measuring pressure
It sets to adjust the pressure of sterilizing-drying.
Embodiment 2
It is added using rice bran as material and carries out sterilizing experiment:
(1) the rice bran micro organism quantity and moisture before measurement sterilizing；Then feed hopper 1 is added in rice bran；
(2) it first is passed through steam into conveying auger and sterilizing drum jacket 6, the temperature for the inner cavity 10 that sterilizes is heated to 90 by steam
DEG C, and vacuumized by vacuum plant, so that sterilizing inner cavity 10 is reached preset temperature and vacuum degree.
(3) start speed reducer 16, open inlet valve 2, fall into the rice bran in feed hopper 1 in sterilization chamber 10, twisted in conveying
It is moved forwards under dragon effect.According to the micro organism quantity and moisture content of rice bran, negative-pressure vacuum degree in control sterilizing inner cavity 10, just
Pressure pressure size and vacuum degree, pressure are held time, and vacuum degree is 0~-0.095Mpa, 0~0.08Mpa of pressure.Pass through frequency conversion
Device control speed reducer 16 institute the revolving speed with variable-frequency motor, adjust the revolving speed of conveying auger, make rice bran from enter sterilization chamber 10 to out
The time of material mouth meets the time required to sterilizing (60 ~ 150min).
(4) after sterilizing, the micro organism quantity and moisture of rice bran are detected.
Embodiment 3
(1) the rice bran micro organism quantity and moisture before measurement sterilizing；Then feed hopper 1 is added in rice bran；
(2) it first is passed through steam into conveying auger and sterilizing drum jacket 6, the temperature for the inner cavity 10 that sterilizes is heated to 95 by steam
DEG C, and vacuumized by vacuum plant, so that sterilizing inner cavity 10 is reached preset temperature and vacuum degree.；
(3) start speed reducer 16, open inlet valve 2, fall into the rice bran in feed hopper 1 in sterilization chamber 10, make in conveying auger
It is moved forwards under.According to the micro organism quantity and moisture content of rice bran, the negative-pressure vacuum degree to sterilize in inner cavity 10, positive pressure pressure are controlled
Power size and vacuum degree, pressure are held time, and vacuum degree is 0~-0.095Mpa, 0~0.08Mpa of pressure.Pass through frequency converter control
Speed reducer 16 processed the revolving speed with variable-frequency motor, adjust the revolving speed of conveying auger, make rice bran from sterilization chamber 10 is entered to discharge port
Time meet sterilizing the time required to (60 ~ 150min).
(4) after sterilizing, the micro organism quantity and moisture of rice bran are detected.
Embodiment 4
(1) the rice bran micro organism quantity and moisture before measurement sterilizing；Then feed hopper 1 is added in rice bran；
(2) it first is passed through steam into conveying auger and sterilizing drum jacket 6, the temperature for the inner cavity 10 that sterilizes is heated to 98 by steam
DEG C, and vacuumized by vacuum plant, so that sterilizing inner cavity 10 is reached preset temperature and vacuum degree.
(3) start speed reducer 16, open inlet valve 2, fall into the rice bran in feed hopper 1 in sterilization chamber 10, twisted in conveying
It is moved forwards under dragon effect.According to the micro organism quantity and moisture content of rice bran, negative-pressure vacuum degree in control sterilizing inner cavity 10, just
Pressure pressure size and vacuum degree, pressure are held time, and vacuum degree is 0~-0.095Mpa, 0~0.08Mpa of pressure.Pass through frequency conversion
Device control speed reducer 16 institute the revolving speed with variable-frequency motor, adjust the revolving speed of conveying auger, make rice bran from enter sterilization chamber 10 to out
The time of material mouth meets the time required to sterilizing (60 ~ 150min).
(4) after sterilizing, the micro organism quantity and moisture of rice bran are detected.
Table 1 is the sterilizing experimental result of embodiment 2-4, the results showed that technique of the invention is used, at 98 DEG C of sterilising temp,
Vacuum degree is 0~-0.095Mpa, has good sterilization effect when 0~0.08Mpa of pressure, and sterilization rate is up to 99.5% or more.
1 rice bran of table sterilizing experimental result
Embodiment 5
Albumen powder sterilizing experiment:
(1) the fish collagen protein powder micro organism quantity before measurement sterilizing, the results are shown in Table 2；Then fish collagen protein powder is added
Enter feed hopper 1；
(2) it first is passed through steam into conveying auger and sterilizing drum jacket 6, the temperature for the inner cavity 10 that sterilizes is heated to 95 by steam
DEG C, and vacuumized by vacuum plant, so that sterilizing inner cavity 10 is reached preset temperature and vacuum degree.；
(3) start speed reducer 16, open inlet valve 2, fall into the fish collagen protein powder in feed hopper 1 in sterilization chamber 10, defeated
It is moved forwards under sending auger to act on.According to the micro organism quantity and moisture content of fish collagen protein powder, control sterilizes in inner cavity 10
Negative-pressure vacuum degree, positive pressure pressure size and vacuum degree, pressure are held time, vacuum degree be 0~-0.095Mpa, pressure 0~
0.08Mpa.By Frequency Converter Control speed reducer 16 the revolving speed with variable-frequency motor, adjust the revolving speed of conveying auger, make collagen
The time required to albumen powder meets sterilizing from the time for entering sterilization chamber 10 to discharge port (60 ~ 150min).
(4) after sterilizing, the micro organism quantity and moisture of fish collagen protein powder are detected.The results are shown in Table 2.
Y-1 in table, Y-2 are the parallel sampling before sterilizing, and 1., 2. A- is to sample in parallel after sterilizing to A-.Illustrate that albumen powder sterilizing is real
It tests and also achieves good sterilization effect.
The present invention makes the microorganism in material under vacuum and pressure alternating state, and microorganism wall expands rapidly even
Explosion inactivation；Cell wall resistance declines under low vacuum and low-pressure state, reduces the tolerable temperature of cell wall, positive pressure negative pressure
Compound action, the deactivation under low-heat (90~98 DEG C) environment, to reach the sterilizing in low-heat.
Low pressure hot air sterilization temperature of the invention is lower than 100 DEG C, and damp and hot using 121 DEG C of sterilizing 15~20min or 115
DEG C sterilizing 30min, xeothermic 115 DEG C, 90min, from temperature i.e. can determine that, keep raw material color it is constant, keep object
Expect after (medicinal material) processes it is raw, ripe, pharmacological property is constant, reservation volatility, low pressure of the invention on temperature-sensitive sexual element are xeothermic to greatest extent
Sterilizing is better than damp and hot and hot air sterilization.
Material easy to knot groups in traditional xeothermic, moist heat sterilization, agglomeration need separating twice, will cause secondary pollution, and of the invention
Low pressure hot air sterilization conveying auger has stirring action, and moisture content low pressure is evaporated, and material is prevented from caking.
Certainly, the present invention can also have other various embodiments, without deviating from the spirit and substance of the present invention, ripe
Various corresponding changes and modifications, but these corresponding changes and modifications can be made according to the present invention by knowing those skilled in the art
It all should belong to the protection scope of the claims in the present invention.
Claims (10)
1. a kind of xeothermic low pressure continuous sterilization process it is characterized in that: being heated by heating device to sterilizing inner cavity, and passes through
Vacuum plant vacuumizes sterilizing inner cavity, adjusts the temperature for the inner cavity that sterilizes when setting sterilizing, material is out of, tubular type sterilizing
One endfeed of chamber is conveyed material from feed inlet to discharge port by conveying auger, according to micro- life of material in sterilization process
Object quantity and moisture content, control negative-pressure vacuum degree and positive pressure pressure are held time, in material transportation process, the combination of positive pressure negative pressure
Effect sterilizes under conditions of being lower than 100 DEG C, what the rotational speed regulation material by adjusting conveying auger stopped in sterilizing inner cavity
Time adjusts sterilization time.
2. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: in sterilization process, vacuum degree 0
~-0.095Mpa, pressure are 0~0.08Mpa.
3. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: the sterilizing collet chuck outside sterilizing inner cavity
Be passed through steam in set and carry out heated material, and/or, the conveying auger be it is hollow, interior logical steam come realize to material heat.
4. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: passing through the revolving speed of control conveying auger
The sterilization time of material is adjusted, type and feature with specific reference to material determines.
5. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: in sterilization process, it can also be by material
After being delivered to sterilizing inner cavity, pause conveying auger works or slows down conveying auger revolving speed, keeps the temperature material in sterilizing inner cavity and protects
Press 60~150min to reach enough sterilization times, the material after being then then exhausted from sterilizing.
6. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: sterilising temp is 90~98 DEG C.
7. xeothermic low pressure continuous sterilization process according to claim 1, it is characterized in that: used xeothermic low pressure is continuously gone out
Bacterium device includes several grades of sterilization cylinders, intracavitary in the sterilizing of sterilization cylinders at different levels to be equipped with conveying auger and for heat sterilization cylinder
Heating device, sterilization cylinders at different levels are equipped with the vacuum port of connection vacuum plant, and the feed inlet of chopped-off head sterilization cylinder is connected with charging dress
It sets, the feed inlet of the discharge port connection next stage sterilization cylinder of every level-one sterilization cylinder, the discharge port of final stage sterilization cylinder is equipped with outlet valve
And connect receiving hopper.
8. xeothermic low pressure continuous sterilization process according to claim 7, it is characterized in that: the heating device includes sterilization cylinder
Sterilizing drum jacket for heating in cylinder, the sterilizing drum jacket of each sterilization cylinder are sequentially communicated, the sterilizing collet chuck of chopped-off head sterilization cylinder
It is arranged steam inlet, the sterilizing drum jacket of final stage sterilization cylinder sets condensation-water drain.
9. xeothermic low pressure continuous sterilization process according to claim 7, it is characterized in that: the conveying auger by hollow shaft and
The hollow ribbon blade being looped around on hollow shaft is constituted.
10. xeothermic low pressure continuous sterilization process according to claim 7, it is characterized in that: sterilization cylinder at different levels is equipped with for clear
The Butterworth Hatch washed.
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| CN113428858A (en) * | 2021-07-16 | 2021-09-24 | 宁国市恒达活性炭有限公司 | Production process of activated carbon for injection |
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