CN110507547A - It is a kind of that material and the preparation method and application thereof is saved based on the compound vital pulp of bioactivity glass/chitosan - Google Patents
It is a kind of that material and the preparation method and application thereof is saved based on the compound vital pulp of bioactivity glass/chitosan Download PDFInfo
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Abstract
Material and the preparation method and application thereof is saved based on the compound vital pulp of bioactivity glass/chitosan the invention discloses a kind of.This saves material based on the compound vital pulp of bioactivity glass/chitosan and is made of solid powder and distiller liquor two parts, solid powder is separately packed with distiller liquor, live reconciliation is carried out when use, it is covered at dental pulp exposure after mixing and dental pulp is saved, it is 1.0-2.0g/mL that the tune of solid powder and distiller liquor, which mixes ratio,.Wherein, solid powder is the SiO-CaO-P of sol-gel method combination template agent method preparation2O5Micro-nano spherical bioactivity glass based on ternary system, distiller liquor is chitosan-phosphate buffer solution.Vital pulp of the invention, which saves material, can protect dental pulp from the stimulation of external environment, have good bioactivity.Meanwhile manufacturing technique of the present invention is simple, and easy to operate, cost is relatively low, and it is easy to spread, it has a good application prospect.
Description
Technical field
The invention belongs to vital pulps to save Material Field, and in particular to a kind of compound based on bioactivity glass/chitosan
Vital pulp saves material and the preparation method and application thereof.
Background technique
Dental pulp is unique soft tissue in tooth, the nutrition being responsible for needed for providing to pulp cells, odontoblast etc.
And oxygen, while it can constantly form dentine.In daily life, since the factors such as wound, saprodontia, operation can all lead to tooth
Marrow exposure, because dental pulp is non-renewable, vital pulp preservation is the treatment optimal means of dental pulp exposure.At present clinically most often
Lid marrow material has calcium hydroxide, mineral trioxide aggregate, but due to the deficiency that it is individually present, can't fully meet
Ideal vital pulp saves the requirement of material.
Calcium hydroxide has been widely used in clinically, but its there is also some side effects.Calcium hydroxide is a kind of highly basic
Property material, when it is directly contacted with dental pulp surface, can make contact site pH increase, cause dental pulp to generate due to strong basicity
Inflammatory reaction even leads to pulp necrosis, has biggish toxicity for cell.Meanwhile for the dental pulp with inflammation
There is no antiinflammation.
Mineral trioxide aggregate largely applies to vital pulp preservation in recent years, but its operability is poor, setting time is up to 4h,
This considerably increases the time costs of doctor and patient；And it is expensive, limit its use scope；In addition, three oxide minerals
Condensate can not degrade, and belong to nondegradable alternative material, cannot carry out in-situ immobilization to lid marrow position.
Bioactivity glass has controllable pattern and structure, can pass through change preparation process and the content of each component
It is adjusted, meet different clinical requirements.In addition, bioactivity glass has good bioactivity, in body fluid
A large amount of ion can be released stimulate cell certain specific genes expression to control the behavior of cell.Bio-vitric
The alkalinity of grain is smaller than calcium hydroxide lid marrow material more, thus directly contact dental pulp when will not generate stimulation pulp tissue and cause
The situation of pulp inflammation even pulp tissue's necrosis.Bioactivity glass also has good biocompatibility and mineralising shape
At the ability of hydroxyapatite, be conducive to accelerate to form reparative dentin.
There is research to treat bioactivity glass applied to lid marrow in recent years, as passed through in patent application CN104644455A
Change glass ingredient to adjust the physical and chemical performance of material.But the glass prepared in the patent application is not that general ingredient contains
Amount, and its design component differs larger with real composition, and component is unstable, is not suitable for clinical expansion, therefore the present invention is with logical
Material is saved with vital pulp based on the micro-nano spherical glass of component and stable components, is prepared for.
Summary of the invention
The purpose of the present invention is saving condensation of materials time long deficiency for existing vital pulp, provide a kind of based on biology
The compound vital pulp of activity glass/chitosan saves material and the preparation method and application thereof, when which condenses when being used as pulp-cap
Between it is short, have good biocompatibility and induced synthesis reparative dentin layer ability, tissue repair can be promoted.Together
When, manufacturing technique of the present invention is simple, and easy to operate, cost is relatively low, and it is easy to spread, it has a good application prospect.
To achieve the goals above, the present invention is realized at least through one of following technical scheme.
It is a kind of that material is saved based on the compound vital pulp of bioactivity glass/chitosan, by solid powder and distiller liquor two
It is grouped as；The solid powder is the SiO of sol-gel method combination template agent method preparation2-CaO-P2O5Based on ternary system
Micro-nano spherical bioactivity glass；The distiller liquor is chitosan-phosphate buffer solution.
Further, it is 1.0-2.0g/mL that the tune of the solid powder and distiller liquor, which mixes ratio,.
Further, the SiO2-CaO-P2O5In micro-nano spherical bioactivity glass based on ternary system,
SiO2, CaO and P2O5Molar ratio be 60:36:4.
Further, the SiO2-CaO-P2O5The partial size of micro-nano spherical bioactivity glass based on ternary system
For 200-800nm.
Further, in the chitosan-phosphate buffer solution, the mass-volume concentration of chitosan is 0.005-
0.02mg/ml, phosphatic molar concentration are 1-5mol/L.
A kind of above-described preparation method that material is saved based on the compound vital pulp of bioactivity glass/chitosan, packet
Include following steps:
(1) SiO2-CaO-P2O5The preparation of micro-nano spherical bioactivity glass based on ternary system: template is dissolved in
It in the mixed solution of second alcohol and water, stirs evenly, then sequentially adds ethyl orthosilicate, triethyl phosphate, four water-calcium nitrate, shape
At milky white solution, white depositions sufficiently are obtained after reaction, is then centrifuged for, dries, being heat-treated and obtain required SiO2-CaO-
P2O5Micro-nano spherical bioactive glass powder based on ternary system；
(2) chitosan-phosphate buffer solution preparation: being dissolved in acetic acid for chitosan, stir to clear viscous shape solution, then plus
Enter dipotassium hydrogen phosphate and sodium dihydrogen phosphate, obtains chitosan-phosphate buffer solution；
(3) bioactivity glass/chitosan vital pulp saves the preparation of material: by SiO2-CaO-P2O5It is micro- based on ternary system
Nanometer spherical bioactive glass powder is separately packed with chitosan-phosphate buffer solution, and it is equal that scene mixing is carried out when use
Even, gained paste obtains saving material based on the compound vital pulp of bioactivity glass/chitosan after solidifying.
Further, in step (1), the template is lauryl amine.
Further, in step (1), its volume ratio is 3-6: 1 in the mixed solution of the ethyl alcohol and deionized water.
Further, in step (1), entire reaction process takes heating water bath, and reaction temperature is controlled at 30-50 DEG C.
Further, in step (1), be added ethyl orthosilicate, triethyl phosphate, four water-calcium nitrate time interval be
20-40min。
Further, in step (1), the white depositions drying condition stood is 50-80 DEG C of dry 24-36 h.
Further, in step (1), the heat treatment is 600-700 DEG C of processing 3-4 h.
A kind of above-described application that material is saved based on the compound vital pulp of bioactivity glass/chitosan, feature
It is, which is used as pulp-cap.
Further, in use, solid powder and distiller liquor are carried out live reconciliation, it is sudden and violent that it is covered in dental pulp after mixing
Dental pulp is protected at dew.
The solidification for the paste that the composite material tune mixes acquisition is related to bioactivity glass, phosphate and chitosan three
Between interaction.Therefore, can be by changing solid-to-liquid ratio, each component concentration etc. adjusts every object of composite material in distiller liquor
Change performance.Bio-vitric can be quickly generated a large amount of hydroxyapatite in phosphate solution between glass particle, secondly its meeting
So that solution alkaline causes the gelation of chitosan, while having the combination of chemical bond between chitosan and hydroxyapatite, with
The collective effect of upper reaction results in the solidification of material.
Compared with prior art, the invention has the advantages that and effect:
(1) solid powder chosen of the present invention is bioactivity glass, have good bioactivity and biocompatibility and
Mineralising formed hydroxyapatite ability, in fluid environment can also by the release of ion, promote pulp cells at
Dentin cell's induction forms reparative dentin layer.
(2) bioactivity glass and chitosan can be degradable in human body fluid, to form biological tissue
In-situ immobilization.
(3) when saving condensation of the material as pulp-cap the present invention is based on the compound vital pulp of bioactivity glass/chitosan
Between it is short, reduce the time cost of doctor and patient.
(4) manufacturing technique of the present invention is simple, easy to operate, and cost is relatively low, easy to spread, has good application
Prospect.
Detailed description of the invention
Fig. 1 is in embodiment 1 using the micro-nano bioactivity glass microballoon of template combination sol-gel method preparation
Tungsten filament scanning electron microscope (SEM) photograph.
Fig. 2 a is respectively obtained based on the compound vital pulp preservation of bioactivity glass/chitosan in the embodiment of the present invention 2
Material conserves the tungsten filament scanning electron microscope (SEM) photograph of 3 d rear surface microstructures.
Fig. 2 b, Fig. 2 c are respectively obtained based on the compound vital pulp of bioactivity glass/chitosan in the embodiment of the present invention 2
It saves material and conserves X ray diffracting spectrum and FTIR spectrum figure after 3 d.
Fig. 3 is obtained feeding based on the compound vital pulp preservation material of bioactivity glass/chitosan in the embodiment of the present invention 2
It protects after 3 d and is immersed in the tungsten filament scanning electron microscope (SEM) photograph of material surface microstructure after 1 day in simulated body fluid.
Fig. 4 is obtained feeding based on the compound vital pulp preservation material of bioactivity glass/chitosan in the embodiment of the present invention 2
It protects after 3 d and is immersed in the tungsten filament scanning electron microscope (SEM) photograph of material surface microstructure after 7 days in simulated body fluid.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention
It is without being limited thereto, for not specifically specified technological parameter, it can refer to routine techniques progress.
Embodiment 1
(1) preparation of bioactive glass powder:
The detailed process for preparing micro-nano bioactive glass powder using template combination sol-gel method is as follows: first by 250
ML deionized water and the mixing of 800 mL dehydrated alcohols obtain mixed solution, add 40 g lauryl amines (DDA), are placed in thermostatted water
It is completely dissolved in bath in 40 °C of lower magnetic agitation to lauryl amines；Then syringe pump is used to add with the injection speed of 0.5 mL/min
Enter ethyl orthosilicate, shows milky as the addition solution of ethyl orthosilicate gradually becomes cloudy in the process, to
217.34 mL ethyl orthosilicates stir 30min after being added；Tricresyl phosphate second is added with the speed of 1mL/min with syringe pump again
Ester stirs 30min after being added to 22.02 mL triethyl phosphates；Then 137.47 g calcium nitrate tetrahydrates are weighed to be dissolved in
In the deionized water of 200 mL, it is slowly added in reaction solution after being heated to 40 °C；Obtained milky white solution is continued to stir
3h is subsequently placed with room temperature ageing for 24 hours；After finally obtained glass colloidal sol dehydrated alcohol and deionization are washed for several times respectively from
It is dry for 24 hours to be placed in 60 °C of drying boxes to white precipitate for gains in depth of comprehension, then is placed in 650 °C of Muffle furnace and is heat-treated 3 h to get 200-
The tungsten filament scanning electron microscope (SEM) photograph of the bioactive glass powder of 800 nm, the bioactivity glass microballoon is as shown in Figure 1.
(2) chitosan-phosphate buffer solution preparation:
0.5g chitosan is added in the 1M acetum of 100mL, is stirred to chitosan is completely dissolved at room temperature, configured
At chitosan solution.22.822g dipotassium hydrogen phosphate and 1g sodium dihydrogen phosphate are added sequentially in chitosan solution, obtain 0.5%
Chitosan-phosphate buffer solution.
(3) preparation of material is saved based on the compound vital pulp of bioactivity glass/chitosan:
The bioactive glass powder of above-mentioned preparation is mixed with 2g/mL tune and to be formed with 0.5% chitosan-phosphate buffer solution
Paste, and insert in stainless steel mould, it is demoulded after 1h, is placed in 37 °C, simulates human body environment in the curing box that humidity is 98%.
Its presetting period is 21.2min, and final setting time 34.5min has certain operability.
Embodiment 2
(1) preparation of bioactive glass powder:
The detailed process for preparing micro-nano bioactive glass powder using template combination sol-gel method is as follows: first will
25mL deionized water and the mixing of 80 mL dehydrated alcohols obtain mixed solution, add 4g lauryl amine (DDA), are placed in thermostatted water
It is completely dissolved in bath in 40 °C of lower magnetic agitation to lauryl amines；Then it adopts
Ethyl orthosilicate is added with the injection speed of 0.5 mL/min with syringe pump, in the process adding with ethyl orthosilicate
Enter solution and gradually become cloudy to show milky, be stirred after being added to 21.73 mL ethyl orthosilicates
Mix 20min；Triethyl phosphate is added with the speed of 1mL/min with syringe pump again, has been added to 2.2 mL triethyl phosphates
20min is stirred after finishing；Then it weighs 13.75 g calcium nitrate tetrahydrates to be dissolved in the deionized water of 200 mL, after being heated to 40 °C
It is slowly added in reaction solution；Obtained milky white solution is continued to stir 3h, is subsequently placed with room temperature ageing for 24 hours；Finally incite somebody to action
To glass colloidal sol dehydrated alcohol and deionization wash for several times that centrifugation obtains white precipitate afterwards respectively, it is dry to be placed in 60 °C of drying boxes
It is dry for 24 hours, then be placed in 650 °C of Muffle furnace and be heat-treated 3 h to get the bioactive glass powder of 200-800 nm.
(2) chitosan-phosphate buffer solution preparation:
1.25g chitosan is added in the 1M acetum of 100mL, is stirred to chitosan is completely dissolved at room temperature, match
It is set to chitosan solution.22.822g dipotassium hydrogen phosphate and 1g sodium dihydrogen phosphate are added sequentially in chitosan solution, obtained
1.25% chitosan-phosphate buffer solution.
(3) preparation of material is saved based on the compound vital pulp of bioactivity glass/chitosan:
Chitosan-phosphate buffer solution of the bioactive glass powder of above-mentioned preparation and 1.25% is mixed into shape with 1.5g/mL tune
It at paste, by the paste filling stainless steel mould of formation, is demoulded after 1h, is placed in 37 °C, mould in the curing box of 98% humidity
Quasi- human body environment.Its presetting period is 8.2min, and final setting time 12.8min has certain operability.
Embodiment 3
(1) preparation of bioactive glass powder:
The detailed process for preparing micro-nano bioactive glass powder using template combination sol-gel method is as follows: first by 50
ML deionized water and the mixing of 160mL dehydrated alcohol obtain mixed solution, add 8 g lauryl amines (DDA), are placed in water bath with thermostatic control
It is completely dissolved in pot in 40 °C of lower magnetic agitation to lauryl amines；Then syringe pump is used to be added with the injection speed of 0.5 mL/min
Ethyl orthosilicate shows milky as the addition solution of ethyl orthosilicate gradually becomes cloudy in the process, to 43.46
ML ethyl orthosilicate stirs 40min after being added；Triethyl phosphate is added with the speed of 1mL/min with syringe pump again, to 4.4
ML triethyl phosphate stirs 40min after being added；Then the deionization that 27.48 g calcium nitrate tetrahydrates are dissolved in 200 mL is weighed
In water, it is slowly added in reaction solution after being heated to 40 °C；Obtained milky white solution is continued to stir 3h, is subsequently placed with room temperature
Ageing is for 24 hours；Finally obtained glass colloidal sol dehydrated alcohol and deionization are washed to be centrifuged afterwards for several times respectively and obtain white precipitate,
It is dry for 24 hours to be placed in 60 °C of drying boxes, then is placed in 650 °C of Muffle furnace and is heat-treated 3 h to get the bioactivity of 200-800 nm
Glass powder.
(2) chitosan-phosphate buffer solution preparation:
2g chitosan is added in the 1M acetum of 100mL, is stirred at room temperature complete to chitosan
Dissolution, is configured to chitosan solution.It is molten that 22.822g dipotassium hydrogen phosphate and 1g sodium dihydrogen phosphate are added sequentially to chitosan
In liquid, 2% chitosan-phosphate buffer solution is obtained.
(3) preparation of material is saved based on the compound vital pulp of bioactivity glass/chitosan:
Chitosan-phosphate buffer solution of the bioactive glass powder of above-mentioned preparation and 2% is mixed to form paste with 1g/mL tune
Shape object demoulds in the paste of formation filling stainless steel mould after 1h, is placed in 37 °C, simulates people in the curing box of 98% humidity
Body environment.Its presetting period is 17.4min, and final setting time 28.7min has certain operability.
It is resulting to embodiment 1,2,3 a kind of based on the compound vital pulp preservation material progress of bioactivity glass/chitosan
It is resulting a kind of based on bioactivity glass to only provide embodiment 2 since the effect picture of embodiment 1,2,3 is similar for characterization
The surface scan electron microscope (see Fig. 2 a) and X ray diffracting spectrum of the compound vital pulp preservation material of glass/chitosan and Fourier are red
External spectrum figure (see Fig. 2 b, Fig. 2 c).After it is conserved 3 days, it is soaked in 1 day and 7 days surface topography of mineralising in simulated body fluid
Scanning electron microscope (SEM) photograph (see Fig. 3, Fig. 4).It has been observed that material is immersed in simulated body fluid after 1 day, material surface is by hydroxyl phosphorus
Lime stone is completely covered, and shows that the material has good bioactivity.
Claims (10)
1. a kind of save material based on the compound vital pulp of bioactivity glass/chitosan, which is characterized in that by solid powder and tune
It is formed with liquid two parts；The solid powder is the SiO of sol-gel method combination template agent method preparation2-CaO-P2O5Ternary system
Micro-nano spherical bioactivity glass based on system；The distiller liquor is chitosan-phosphate buffer solution.
2. according to claim 1 a kind of based on the compound vital pulp preservation material of bioactivity glass/chitosan, feature
It is, it is 1.0-2.0g/mL that the tune of the solid powder and distiller liquor, which mixes ratio,.
3. according to claim 1 a kind of based on the compound vital pulp preservation material of bioactivity glass/chitosan, feature
It is, the SiO2-CaO-P2O5In micro-nano spherical bioactivity glass based on ternary system, SiO2, CaO and P2O5's
Molar ratio is 60:36:4.
4. according to claim 1 a kind of based on the compound vital pulp preservation material of bioactivity glass/chitosan, feature
It is, the SiO2-CaO-P2O5The partial size of micro-nano spherical bioactivity glass based on ternary system is 200-800nm.
5. it is according to claim 1 a kind of based on the compound vital pulp preservation material of bioactivity glass/chitosan, it is special
Sign is, in the chitosan-phosphate buffer solution, the mass-volume concentration of chitosan is 0.005-0.02mg/ml, phosphoric acid
The molar concentration of salt is 1-5mol/L.
6. it is described in any item a kind of based on the compound vital pulp preservation material of bioactivity glass/chitosan to prepare claim 1-5
The method of material, which comprises the steps of:
(1) SiO2-CaO-P2O5The preparation of micro-nano spherical bioactivity glass based on ternary system: template is dissolved in
It in the mixed solution of second alcohol and water, stirs evenly, then sequentially adds ethyl orthosilicate, triethyl phosphate, four water-calcium nitrate, shape
At milky white solution, white depositions sufficiently are obtained after reaction, is then centrifuged for, dries, being heat-treated and obtain required SiO2-CaO-
P2O5Micro-nano spherical bioactive glass powder based on ternary system；
(2) chitosan-phosphate buffer solution preparation: being dissolved in acetic acid for chitosan, stir to clear viscous shape solution, then plus
Enter dipotassium hydrogen phosphate and sodium dihydrogen phosphate, obtains chitosan-phosphate buffer solution；
(3) bioactivity glass/chitosan vital pulp saves the preparation of material: by SiO2-CaO-P2O5It is micro- based on ternary system
Nanometer spherical bioactive glass powder is separately packed with chitosan-phosphate buffer solution, and it is equal that scene mixing is carried out when use
It is even, it obtains and material is saved based on the compound vital pulp of bioactivity glass/chitosan.
7. preparation method as claimed in claim 6, which is characterized in that in step (1), the template is lauryl amine, the second
Volume ratio of the alcohol and water in mixed solution is 3-6: 1, and entire reaction process takes heating water bath, and reaction temperature is controlled in 30-
50℃。
8. preparation method as claimed in claim 6, which is characterized in that in step (1), be added ethyl orthosilicate, triethyl phosphate,
The time interval of four water-calcium nitrate is 20-40min；Standing obtained white depositions drying condition is 50-80 DEG C of dry 24-
36h；The heat treatment is 600-700 DEG C of processing 3-4h.
9. claim 1-5 is described in any item a kind of to save material based on the compound vital pulp of bioactivity glass/chitosan
Using, which is characterized in that the material is used as pulp-cap.
10. application according to claim 9, which is characterized in that in use, solid powder and distiller liquor are carried out live tune
Be covered at dental pulp exposure after mixing and dental pulp protected.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237550A (en) * | 2020-11-24 | 2021-01-19 | 武汉幸福益生再生医学科技有限公司 | Dental filling material of bioactive glass material and filling method thereof |
| CN114259412A (en) * | 2022-02-23 | 2022-04-01 | 北京大学口腔医学院 | Preparation method of light-curable bioactive pulp covering material |
| CN114381017A (en) * | 2022-01-06 | 2022-04-22 | 浙江大学医学院附属第一医院 | Nano bioactive glass hydrogel composite material and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843994A (en) * | 2006-04-21 | 2006-10-11 | 华南理工大学 | Bioactive glass nano powder and its biomimetic synthesis method |
| CN1974448A (en) * | 2006-12-01 | 2007-06-06 | 华南理工大学 | Prepn process of bioactive sol-gel glass fiber |
| CN101314039A (en) * | 2008-07-03 | 2008-12-03 | 华南理工大学 | Biological activity glass mesoporous microsphere and preparation method thereof |
| CN101642589A (en) * | 2009-09-11 | 2010-02-10 | 华南理工大学 | Preparation method of biological active glass/chitosan composite porous support material |
| CN102580148A (en) * | 2012-03-12 | 2012-07-18 | 华南理工大学 | Preparation method of composite stent for repairing bone defect |
| CN102625690A (en) * | 2009-04-01 | 2012-08-01 | 高露洁-棕榄公司 | Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof |
| CN104644455A (en) * | 2015-01-26 | 2015-05-27 | 华南理工大学 | Bioglass-sodium alginate composite biomaterial, kit and application |
| CN105435303A (en) * | 2015-11-30 | 2016-03-30 | 华南理工大学 | Enhanced type bioactive glass scaffold and preparation method thereof |
| CN106620859A (en) * | 2016-11-19 | 2017-05-10 | 华南理工大学 | Bioactive glass composite scaffold and preparation method thereof |
| CN107049798A (en) * | 2017-04-14 | 2017-08-18 | 华南理工大学 | It is a kind of to be used to treat desensitizer of dental hypersensitiveness and preparation method thereof |
-
2019
- 2019-09-27 CN CN201910925451.9A patent/CN110507547B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843994A (en) * | 2006-04-21 | 2006-10-11 | 华南理工大学 | Bioactive glass nano powder and its biomimetic synthesis method |
| CN1974448A (en) * | 2006-12-01 | 2007-06-06 | 华南理工大学 | Prepn process of bioactive sol-gel glass fiber |
| CN101314039A (en) * | 2008-07-03 | 2008-12-03 | 华南理工大学 | Biological activity glass mesoporous microsphere and preparation method thereof |
| CN102625690A (en) * | 2009-04-01 | 2012-08-01 | 高露洁-棕榄公司 | Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof |
| CN101642589A (en) * | 2009-09-11 | 2010-02-10 | 华南理工大学 | Preparation method of biological active glass/chitosan composite porous support material |
| CN102580148A (en) * | 2012-03-12 | 2012-07-18 | 华南理工大学 | Preparation method of composite stent for repairing bone defect |
| CN104644455A (en) * | 2015-01-26 | 2015-05-27 | 华南理工大学 | Bioglass-sodium alginate composite biomaterial, kit and application |
| CN105435303A (en) * | 2015-11-30 | 2016-03-30 | 华南理工大学 | Enhanced type bioactive glass scaffold and preparation method thereof |
| CN106620859A (en) * | 2016-11-19 | 2017-05-10 | 华南理工大学 | Bioactive glass composite scaffold and preparation method thereof |
| CN107049798A (en) * | 2017-04-14 | 2017-08-18 | 华南理工大学 | It is a kind of to be used to treat desensitizer of dental hypersensitiveness and preparation method thereof |
Non-Patent Citations (7)
| Title |
|---|
| JING ZHANG等: "Chitosan-bioglass complexes promote subsurface remineralisation of incipient human carious enamel lesions", 《JOURNAL OF DENTISTRY》 * |
| JOANA MOTA等: "Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration", 《ACTA BIOMATERIALIA》 * |
| PARASTOO KHOSHAKHLAGHA等: "Development and characterization of a bioglass/chitosan composite as an injectable bone substitute", 《CARBOHYDRATE POLYMERS》 * |
| 吕杰等: "《新型材料科学与技术.无机材料卷》", 31 October 2016, 华南理工大学出版社 * |
| 孙晨等: "生物活性玻璃与壳聚糖复合的骨修复材料", 《中国组织工程研究》 * |
| 方亮: "《药用高分子材料学》", 31 August 2015, 中国医药科技出版社 * |
| 胡庆: "用于牙髓损伤修复的新型微纳米生物活性玻璃的仿生制备及性能研究", 《中国博士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112237550A (en) * | 2020-11-24 | 2021-01-19 | 武汉幸福益生再生医学科技有限公司 | Dental filling material of bioactive glass material and filling method thereof |
| CN114381017A (en) * | 2022-01-06 | 2022-04-22 | 浙江大学医学院附属第一医院 | Nano bioactive glass hydrogel composite material and preparation method thereof |
| CN114259412A (en) * | 2022-02-23 | 2022-04-01 | 北京大学口腔医学院 | Preparation method of light-curable bioactive pulp covering material |
| CN114259412B (en) * | 2022-02-23 | 2023-05-26 | 北京大学口腔医学院 | Preparation method of photocurable bioactive marrow covering material |
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