CN110507405A - The cryoablation needle of adjustable targeting district - Google Patents

The cryoablation needle of adjustable targeting district Download PDF

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Publication number
CN110507405A
CN110507405A CN201910752750.7A CN201910752750A CN110507405A CN 110507405 A CN110507405 A CN 110507405A CN 201910752750 A CN201910752750 A CN 201910752750A CN 110507405 A CN110507405 A CN 110507405A
Authority
CN
China
Prior art keywords
instlated tubular
back segment
end sealing
leading portion
mandrel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910752750.7A
Other languages
Chinese (zh)
Inventor
杨迟
徐彬凯
吴银龙
常兆华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI DAOXIANG MEDICAL SYSTEM CO Ltd
Original Assignee
SHANGHAI DAOXIANG MEDICAL SYSTEM CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHANGHAI DAOXIANG MEDICAL SYSTEM CO Ltd filed Critical SHANGHAI DAOXIANG MEDICAL SYSTEM CO Ltd
Priority to CN201910752750.7A priority Critical patent/CN110507405A/en
Publication of CN110507405A publication Critical patent/CN110507405A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00791Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0231Characteristics of handpieces or probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0293Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle

Abstract

The present invention relates to a kind of cryoablation needles of adjustable targeting district, including regulating member and fixation member, the regulating member can be axially moved to adjust the length of targeting district relative to the fixation member: fixation member includes shank, back segment instlated tubular, air inlet pipe fitting and muffler, the rear end of shank is fixedly connected with the front end of back segment instlated tubular, and shank communicates with back segment instlated tubular and forms accommodating cavity;Air inlet pipe fitting and muffler are inserted into accommodating cavity from the rear end of back segment instlated tubular;Regulating member includes leading portion instlated tubular and mandrel, and leading portion instlated tubular slides axially the length for being arranged in and adjusting targeting district in accommodating cavity;Air inlet pipe fitting passes through leading portion instlated tubular and extends in shank;Mandrel is inserted into from the rear end of back segment instlated tubular and links with leading portion instlated tubular, and the present invention solves existing cryoablation needle and causes to treat complicated for operation and easy the technical issues of injuring periphery health tissues because targeting district is fixed.

Description

The cryoablation needle of adjustable targeting district
Technical field
The present invention relates to cryoablation needle, in particular to the cryoablation needle of adjustable targeting district.
Background technique
Cryoablation is a kind of therapeutic modality that pathological tissues are destroyed using low temperature, it is considered to be a kind of to treat pernicious swell Efficient, the invasive methods of tumor.Cryoablation technical operation simplicity, few intercurrent disease, effectively analgesia, moreover, the ice hockey that ablation is formed Sharpness of border, convenient for observation, can the ablation of safety close on the lesion of big blood vessel or important organ.Cryoablation can also take spininess The mode of freezing keeps ablation range bigger, is suitable for big lesion and form Irregular focus.
Targeting district (i.e. effective freeze space) is located at the syringe needle leading portion of cryoablation needle, and length determines the big of freezing range Small, targeting district is longer, and the ice hockey for freezing formation is bigger.But the targeting district of existing cryoablation needle is mostly fixed structure, The size of its ice hockey generated is also fixation, and in clinical application, doctor need to select different targeting districts according to the size of lesion The cryoablation needle of length.For pathological tissues in irregular shape, the probe using a variety of different sizes is needed, it is reciprocal to carry out Repeatedly treatment operation, and easily injure periphery health tissues.Such as " pears " shape tumour small for the big tail end of head end, it is clinical at this stage In can be used it is single the cryoablation needle of long targeting district is melted on a large scale, but in this way can the middle part of " pears " one enclose damage compared with More normal tissues;Can also front and back place the cryoablation needle freezing different time of two short targeting districts to realize ablation, but It will increase the expense and difficulty of operation in this way.
Summary of the invention
The purpose of the present invention is to provide a kind of cryoablation needles of adjustable targeting district, to solve existing cryoablation needle It causes to treat complicated for operation and easy the technical issues of injuring periphery health tissues because targeting district is fixed.
To solve the above-mentioned problems, the present invention provides a kind of cryoablation needles of adjustable targeting district, including regulating member And fixation member, the regulating member can be axially moved to adjust the length of targeting district relative to the fixation member:
The fixation member includes shank, back segment instlated tubular, air inlet pipe fitting and muffler, the rear end of the shank with it is described The front end of back segment instlated tubular is fixedly connected, and the shank communicates with the back segment instlated tubular and forms accommodating cavity;The air inlet pipe Part and muffler are inserted into the accommodating cavity from the rear end of the back segment instlated tubular;
The regulating member includes leading portion instlated tubular and mandrel, and the leading portion instlated tubular, which slides axially, to be arranged in the accommodating It is intracavitary that with the length that adjusts targeting district, (leading portion instlated tubular can be stretched in shank, the front end of leading portion instlated tubular and the front end of needle point Between vertical range be targeting district length);The air inlet pipe fitting passes through the leading portion instlated tubular and extends in shank;Institute Mandrel is stated to be inserted into from the rear end of the back segment instlated tubular and link with the leading portion instlated tubular.
Preferably, the shank is coated on the leading portion instlated tubular, the outer wall and the back segment of the leading portion instlated tubular It is connected between the inner wall of instlated tubular by the forward end seal component dynamic sealing.
Preferably, the forward end seal component includes forward end seal coil assembly and intermediate connection tube, the forward end seal circle Component is arranged between the outer wall of the leading portion instlated tubular and the inner wall of the back segment instlated tubular;The front end of the intermediate connection tube It is fixedly connected and communicates with the leading portion instlated tubular, rear end is fixedly connected with the mandrel.
Preferably, the forward end seal coil assembly includes that front end gear sealing ring baffle and forward end seal circle, the front end are close Seal baffle fixing sleeve is set to the front end or/and leading portion instlated tubular rear end of the intermediate connection tube, the forward end seal circle baffle It is equipped with the groove for accommodating the forward end seal circle, the forward end seal circle is fixed in this groove.
Preferably, the internal diameter of the back segment instlated tubular is greater than the internal diameter of the shank.
Preferably, the air inlet pipe fitting includes J-T slot, finned tube and air inlet pipe, the both ends of the finned tube respectively with institute It states J-T slot to be fixedly connected and communicate with air inlet pipe, the finned tube is wound on outside the mandrel;
Return-air slot is offered on the tube wall of the intermediate connection tube, the J-T slot pierces into institute out of export-oriented the return-air slot State in leading portion instlated tubular and extend to the front end of the shank.
Preferably, the fixation member further includes back-end sealing component, lead between the mandrel and the back segment instlated tubular Cross the back-end sealing component dynamic sealing connection.
Preferably, the back segment seal ring assembly includes two back-end sealing circle baffles and back-end sealing circle, a rear end Sealing ring baffle is fixed on the inner wall of the back segment instlated tubular, and the two back-end sealing circle baffle fits are described in fixation Back-end sealing circle, the mandrel pass through the back-end sealing circle and connect with its dynamic sealing;
Two fairleads are also provided on the back-end sealing circle baffle, the air inlet pipe and muffler are individually fixed in an institute It states in fairlead.
Preferably, the back-end sealing component includes back-end sealing coil assembly and extension, the front end of the extension is solid In the rear end face of the back segment instlated tubular, the rear end of the extension is arranged in the back-end sealing coil assembly, described for fixed connection Mandrel passes through the extension and connect with the back-end sealing coil assembly dynamic sealing.
Preferably, the rear end face of the back segment instlated tubular also opens up two fairleads, the air inlet pipe and muffler are solid respectively Due in a fairlead.
Preferably, the back-end sealing coil assembly includes two back-end sealing circle baffles and back-end sealing circle, a rear end Sealing ring baffle is installed in the rear end of the extension, and the two back-end sealing circle baffle fits are with the fixation back-end sealing Circle, the mandrel pass through the back-end sealing circle and connect with its dynamic sealing.
Preferably, the regulating member further includes an adjusting sleeve pipe, it is heat-insulated to be sheathed on the back segment outside the adjusting sleeve pipe It manages, a fixed driving lever on the adjusting sleeve pipe, the rear end of the adjusting sleeve pipe offers guidance window and mandrel connecting hole, described Mandrel passes through the mandrel connecting hole and is fixedly connected with the mandrel connecting hole.
Preferably, the fixation member further includes handle, the handle fixation is set in the shank or/and back segment is heat-insulated Guan Shang, in the gap between the handle and the back segment instlated tubular, the handle is equipped with to be adjusted the adjusting sleeve pipe Slot, driving lever are stretched out from the regulating tank.
Preferably, the fixation member further includes back-end sealing component, the back-end sealing component includes back-end sealing circle Component, the muffler are set in the rear end of the handle, and the air inlet pipe is located in the muffler, the back segment instlated tubular It is connect between the adjusting sleeve pipe by the back-end sealing coil assembly dynamic sealing.
Preferably, the back-end sealing coil assembly includes two back-end sealing circle baffles and back-end sealing circle, a rear end Sealing ring baffle is fixed on the outer wall of the back segment instlated tubular, and the two back-end sealing circle baffle fits are described in fixation Back-end sealing circle, the back-end sealing circle are contacted with the inner wall of the adjusting sleeve pipe and are connect with its dynamic sealing.
Preferably, the fixation member further includes wire component, the wire component includes thermometric line and electric wire fairlead, The electric wire fairlead is fixed on the rear end of the back segment instlated tubular, the thermometric line sequentially pass through leading portion instlated tubular, return-air slot, The gap of finned tube and electric wire fairlead are drawn outside needle, and the temperature measuring point of the thermometric line is located at the leading portion of the J-T slot.
Preferably, the inside of the electric wire fairlead, which fills, sets glue, the thermometric line is drawn by glue and the electric wire Seal of tube connection.
Preferably, the regulating member further includes thermometric line, the mandrel is hollow tubular product, and the thermometric line sequentially passes through Leading portion instlated tubular, intermediate connection tube, mandrel are led to outside needle, and the temperature measuring point is located at the front end of leading portion instlated tubular.
Preferably, the inside of the mandrel, which fills, is equipped with glue, the thermometric line is connect by glue with the stem seal.
Preferably, the tube wall of the back segment instlated tubular be double-layer vacuum wall, the back segment instlated tubular include back segment inner tube and Back segment outer tube forms vacuum interlayer between the back segment inner tube and back segment outer tube.
Preferably, the tube wall of the leading portion instlated tubular be double-layer vacuum wall, the leading portion instlated tubular include leading portion inner tube and Leading portion outer tube forms vacuum interlayer between the leading portion inner tube and leading portion outer tube.
Compared with prior art, there are following technical effects by the present invention:
1, the length adjustment that targeting district is realized using the method for mandrel linkage leading portion instlated tubular is solved existing freezing and disappeared Melt needle to cause to treat complicated for operation and easy the technical issues of injuring periphery health tissues because targeting district is fixed;
2, it is securely welded between shank and back segment instlated tubular, can avoid shank and projected by high pressure gas, be also prevented from low temperature gas Body leaks in the position close to patient;Back segment instlated tubular is located at the hand steered position held of doctor, can prevent frostbite, and avoid cooling capacity stream It loses;
3, the adjusting of targeting district need to only be completed from syringe needle rear operating, it is not necessary that shank and back segment instlated tubular are separated from each other, It is securely welded between shank and rear end instlated tubular, effectively avoids causing shank to be penetrated by high pressure gas since return gas channel blocks Out;
4, forward end seal component is placed in needle, when for avoiding sealing ring from failing, causes frostbite to patient or doctor;
5, back-end sealing component is located at syringe needle rear portion, for preventing outside return-air airflow leaks to needle;
6, forward end seal component is located inside needle, and back-end sealing component is located at syringe needle rear portion, once seal failure and occur Leakage, cold air can only be discharged from the position far from patient and doctor's hand, not will cause frostbite, it is ensured that the safety of operation;
7, using the method for mandrel linkage leading portion instlated tubular, existing adjustable targeting district cryoablation needle is solved using outer Reveal the method for (leading portion) instlated tubular and caused by the too long problem of (leading portion) instlated tubular.Leading portion instlated tubular is always positioned in shank Portion, can effectively shorten the length of leading portion instlated tubular, and then return-air is more smooth, and the back pressure in shank is lower, and the temperature of syringe needle is lower, It is better to freeze performance;
8, during targeting district is adjusted, there is one section of overlapping in leading portion instlated tubular and back segment instlated tubular always between each other Region can release to avoid cooling capacity from the middle position of thermal insulation areas in this way.
Certainly, it implements any of the products of the present invention and does not necessarily require achieving all the advantages described above at the same time.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, required use in being described below to embodiment Attached drawing be briefly described, it is therefore apparent that drawings in the following description are only some embodiments of the invention, for ability For field technique personnel, without creative efforts, it is also possible to obtain other drawings based on these drawings.It is attached In figure:
Fig. 1 is a kind of schematic diagram of the cryoablation needle of adjustable targeting district of the present invention;
Fig. 2 is the structural schematic diagram of regulating member in the present invention;
Fig. 3 is the cross-sectional view A-A of regulating member in the present invention;
Fig. 4 is the structural schematic diagram of forward end seal component in the present invention;
Fig. 5 is the cross-sectional view B-B of forward end seal component in the present invention;
Fig. 6 is the structure of the cryoablation needle of the adjustable targeting district for the embodiment that present invention China and foreign countries postpone end seal assembly Schematic diagram;
Fig. 7 is the structural schematic diagram for the embodiment that present invention China and foreign countries postpone end seal assembly;
Fig. 8 is the cross-sectional view C-C for the embodiment that present invention China and foreign countries postpone end seal assembly;
Fig. 9 is a kind of structural representation of an embodiment of the most short targeting district of the cryoablation needle of adjustable targeting district of the present invention Figure;
Figure 10 is that a kind of structure of an embodiment of the longest targeting district of the cryoablation needle of adjustable targeting district of the present invention is shown It is intended to;
Figure 11 is a kind of section view of an embodiment of the longest targeting district of the cryoablation needle of adjustable targeting district in the present invention Scheme D-D;
Figure 12 is the cryoablation needle of the adjustable targeting district for another embodiment that present invention China and foreign countries postpone end seal assembly Partial structural diagram;
Figure 13 is the structural schematic diagram for another embodiment that present invention China and foreign countries postpone end seal assembly;
Figure 14 is the cross-sectional view E-E for another embodiment that present invention China and foreign countries postpone end seal assembly;
Figure 15 is the cryoablation needle of the adjustable targeting district for the third embodiment that present invention China and foreign countries postpone end seal assembly Partial structural diagram;
Figure 16 is the cryoablation needle of the adjustable targeting district for the third embodiment that present invention China and foreign countries postpone end seal assembly Cross-sectional view F-F;
Figure 17 is the implementable structural schematic diagram that thermometric line is drawn in finned tube gap in the present invention;
Figure 18 is the structural schematic diagram that mandrel draws thermometric line in the present invention;
Figure 19 is the process signal of adjustable conformal ablation " pears " shape tumour of targeting district cryoablation needle in the present invention.
Specific embodiment
It is detailed to a kind of cryoablation needle progress of adjustable targeting district provided by the invention below with reference to Fig. 1 to Figure 19 Description, the present embodiment implemented under the premise of the technical scheme of the present invention, gives detailed embodiment and specific Operating process, but protection scope of the present invention is not limited to following embodiments, and those skilled in the art are not changing essence of the invention In the range of mind and content, can it be modified and be polished.
Fig. 1 to Figure 19, a kind of cryoablation needle of adjustable targeting district, including regulating member 1 and fixation member 2 are please referred to, The regulating member 1 can be moved relative to the fixation member 2 with the adjustable targeting district 3 of outer surface formation length in ablation needle With thermal insulation areas 4, in the present invention, the length of targeting district 3 and thermal insulation areas 4 is adjustable:
The fixation member 2 includes shank 21, back segment instlated tubular 22, air inlet pipe fitting 24 and muffler 25, the shank 21 Rear end be fixedly connected with the front end of the back segment instlated tubular 22, the shank 21 is communicated and is formed with the back segment instlated tubular 22 Accommodating cavity;The air inlet pipe fitting 24 and muffler 25 are inserted into the accommodating cavity from the rear end of the back segment instlated tubular 22;
The regulating member 1 includes leading portion instlated tubular 12 and mandrel 11, and the leading portion instlated tubular 12, which slides axially to be arranged, to exist The length of targeting district 3 is adjusted in the accommodating cavity;The air inlet pipe fitting 24 passes through the leading portion instlated tubular 12 and extends to needle In bar 21;The mandrel 11 is inserted into from the rear end of the back segment instlated tubular 22 and links with the leading portion instlated tubular 12.
In the present embodiment, the shank 21 is coated on the leading portion instlated tubular 12, outside the leading portion instlated tubular 12 It is connected between wall and the inner wall of the back segment instlated tubular 22 by 13 dynamic sealing of forward end seal component.Leading portion instlated tubular 12 Between front end face and the needle point front end of shank 21 ablation needle outer surface formed region be targeting district 3, this region is effective Freeze region.The region formed between the front end of leading portion instlated tubular 12 and the rear end of back segment instlated tubular 22 in the outer surface of ablation needle For thermal insulation areas 4, this thermal insulation areas 4 can prevent normal tissue frostbite.In the present embodiment, mandrel 11, leading portion instlated tubular 12 and front end 13 three of seal assembly is integrated front and back and does piston motion to adjust the length of targeting district 3 and thermal insulation areas 4.
In the present embodiment, the front end of leading portion instlated tubular 12 is protruded into shank 21, and rear end is protruded into back segment instlated tubular 22, preceding Section instlated tubular 12 is heat-insulated for 21 back segment of shank, and forward end seal component 13 is axial piston sealing structure, for preventing return-air Gap of the air-flow between shank 21 and leading portion instlated tubular 12 passes through.Shank 21 and back segment instlated tubular 22 are axially solderable or one Body formed, the present invention is to this and is not particularly limited, it is therefore an objective to be avoided shank 21 from being projected by high pressure gas, be also prevented from cryogenic gas It leaks in the position close to patient.Back segment instlated tubular 22 is located at the hand steered position held of doctor, can prevent frostbite, and avoid cooling capacity stream It loses.
Fixation member 2 further includes back-end sealing component 23, and back-end sealing component 23 is also axial piston sealing structure, after this End seal assembly 23 is for preventing outside return-air airflow leaks to needle.
Air inlet pipe fitting 24 is inserted into from the rear end of back segment instlated tubular 22, and extends to the front end inside shank 21, is used for High pressure gas is conveyed and is throttled to targeting district 3, the gas after throttling is after 3 released cold quantity of targeting district again through leading portion instlated tubular 12 Outside 25 discharging pin of muffler.Specifically, air inlet pipe fitting 24 includes J-T slot 241, finned tube 242 and air inlet pipe 243, the wing The both ends of piece pipe 242 are welded and are connected to the J-T slot 241 and air inlet pipe 243 respectively, and the finned tube 242 is with certain spiral shell Away from being wound on outside the mandrel 11, J-T slot 241 is passed through from return-air slot 1331, so that regulating member 1 will not in adjustment process Influence the position of air inlet pipe fitting 24.
In the present embodiment, in the adjustment process of targeting district 3, leading portion instlated tubular 12 and back segment instlated tubular 22 it is mutual it Between always exist one section of overlapping region, can thus be discharged to avoid cooling capacity from the middle position of thermal insulation areas 4.
In the present embodiment, forward end seal component 13 is located inside needle, and back-end sealing component 23 is located at needle rear end, once hair Raw leakage, cold air can only be discharged from the position far from patient and doctor's hand, it is ensured that the safety of operation.
The cryoablation needle being inserted into side by side for muffler 25 and air inlet pipe 243 in back segment instlated tubular 22, back-end sealing group Part 23 for the piston seal between 22 inner wall of mandrel 11 and back segment instlated tubular, back-end sealing component 23 external to back segment every Heat pipe 22 is also built-in in back segment instlated tubular 22.
The cryoablation needle of air inlet pipe 243 is coated at for muffler 25, back-end sealing component 23 is used for back segment instlated tubular Piston seal between 22 and adjusting sleeve pipe 14, back-end sealing component 23 are placed outside the rear end of back segment instlated tubular 22.
Below in conjunction with attached drawing, lifts several specific embodiments and be described in detail.
Embodiment 1
It is made referring to FIG. 3, heat-barrier material can be used in the tube wall of leading portion instlated tubular 12, double-layer vacuum wall can also be used, The present invention is not particularly limited, the preferred double-layer vacuum wall of the present embodiment, i.e., the described leading portion instlated tubular 12 includes 122 He of leading portion inner tube Leading portion outer tube 121 forms vacuum interlayer between the leading portion inner tube 122 and leading portion outer tube 121.
As one embodiment, the both ends necking of the leading portion outer tube 121 and with the 122 vacuum welding shape of leading portion inner tube At permanent vacuum interlayer;
As another embodiment, the leading portion inner tube 122 both ends flaring and with 121 vacuum welding of leading portion outer tube It connects to form permanent vacuum interlayer;
As the third embodiment, the two-port of the leading portion inner tube 122 and the two-port of the leading portion outer tube 121 are neat It is flat, and permanent vacuum interlayer is formed between the two.
Fig. 4 and Fig. 5 are please referred to, forward end seal component 13 includes forward end seal circle 131 and intermediate connection tube 133, and centre connects The front end of adapter tube 133 is inserted in leading portion instlated tubular 12 and is welded, and rear end is inserted in mandrel 11 and is welded.The present embodiment is to forward end seal circle 131 specific setting structure is with no restrictions:
As one embodiment, recessed in the front end of intermediate connection tube 133 or one annular of the rear end of leading portion instlated tubular 12 setting Slot, forward end seal circle 131 are embedded in this annular groove;
Alternatively embodiment, forward end seal circle 131 are set to the centre by forward end seal circle baffle fixing sleeve 12 rear end of front end or/and leading portion instlated tubular of connecting tube 133, the forward end seal circle baffle, which is equipped with, accommodates the forward end seal The groove of circle 131, the forward end seal circle are fixed in this groove.Specifically, fixed two front end in the front end of intermediate connection tube 133 Sealing ring baffle 132, the setting of two forward end seal circle baffles 132 interval, forward end seal circle 131 are embedded in two forward end seal circle baffles Between 132.Two forward end seal circle baffles 132 can be made into integration, and form the outer recessed of fixed forward end seal circle 131 between the two Slot;It is also possible to a forward end seal circle baffle 132 to be welded on the outer wall of intermediate connection tube 133, two forward end seal circle baffles 132 can be connected by way of screw threads for fastening, form an external groove, forward end seal circle between two forward end seal circle baffles 132 131 fixations are embedded in this external groove, and the purpose of two forward end seal circle baffles 132 being detachably connected is to facilitate forward end seal circle 131 replacement.
The internal diameter of the back segment instlated tubular 22 is greater than the internal diameter of the shank 21, and leading portion instlated tubular 12 passes through forward end seal group The blocking of part 13 is always positioned in back segment instlated tubular 22, will not be entered in shank 21, it is therefore an objective in the adjustment process of targeting district 3 In, there is one section of overlapping region in leading portion instlated tubular 12 and back segment instlated tubular 22, will not generate between the two always between each other It is detached from, can thus be discharged to avoid cooling capacity from the middle position of thermal insulation areas 4.
In the present embodiment, back segment instlated tubular 22 is straight tube, but the present invention is not limited thereto, is also possible to bend pipe, this Embodiment is described in detail by taking straight tube as an example.
Return-air slot 1331 is offered on the tube wall of intermediate connection tube 133, the present embodiment does not do the number of return-air slot 1331 Limitation, can be one or two, which is used to the return-air inside leading portion instlated tubular 12 being emitted into forward end seal Outside component 13.
In the present embodiment, mandrel 11 is solid bar.
In the present embodiment, dynamic by the back-end sealing component 23 between the mandrel 11 and the back segment instlated tubular 22 It is tightly connected.
The tube wall of back segment instlated tubular 22 can be made of heat-barrier material, can also use double-layer vacuum wall, the present invention is not Do concrete restriction, the preferred double-layer vacuum wall of the present embodiment, the i.e. tube wall of back segment instlated tubular 22 are double-layer vacuum wall, the back segment every Heat pipe 22 includes back segment inner tube 222 and back segment outer tube 221, forms vacuum clip between the back segment inner tube 222 and back segment outer tube 221 Layer.The both ends necking of the back segment outer tube 221 simultaneously forms permanent vacuum interlayer with 222 vacuum welding of back segment inner tube;Or, institute It states the both ends flaring of back segment inner tube 222 and forms permanent vacuum interlayer with 221 vacuum welding of back segment outer tube.
In the present embodiment, muffler 25 and air inlet pipe 243 are inserted into the rear end of back segment instlated tubular 22, back-end sealing group side by side Part 23 is for the piston seal between 22 inner wall of mandrel 11 and back segment instlated tubular.Back-end sealing component 23 is heat-insulated external to back segment Pipe 22, also built-in in back segment instlated tubular 22:
Fig. 6 to Figure 11 is please referred to, as one embodiment, back-end sealing component 23 is placed outside back segment inner tube 222, back segment After the rear end necking of outer tube 221 with 222 vacuum welding of back segment inner tube.Back-end sealing component 23 includes back-end sealing coil assembly and prolongs Stretch pipe 233, the purpose of extension 233 is that the position of back-end sealing coil assembly extends back, avoid back-end sealing component 23 with Interfere between air inlet pipe 243 and muffler 25.In the present embodiment, the front end of extension 233 and back segment inner tube 222 are welded, after End seal ring assembly is arranged in the rear end of extension 233, mandrel 11 extend through pipe 233 and with back-end sealing coil assembly dynamic sealing Connection.Back-end sealing coil assembly includes two back-end sealing circle baffles 232 and back-end sealing circle 231, a back-end sealing circle baffle 232 are fixed on extension 233, and two back-end sealing circle baffles 232 can be connected by way of screw threads for fastening, two back-end sealing circles An inner groovy is formed between baffle 232, the fixation of back-end sealing circle 231 is embedded on this inner groovy, two back-end sealing circle baffles 232 The purpose being detachably connected be to facilitate the replacement of back-end sealing circle 231.In the present embodiment, back-end sealing circle 231 and mandrel 11 outer wall contact, mandrel 11 are connect with 231 dynamic sealing of back-end sealing circle.
In the present embodiment, after air inlet pipe 243, muffler 25 and 233 three of extension are inserted into back segment inner tube 222 End, and the outer wall of air inlet pipe 243, muffler 25 and extension 233 passes through seamless welding between back segment inner tube 222 Sealing:
As one embodiment, back segment instlated tubular 22 has aft bulkhead, and aft bulkhead interval opens up three for air inlet pipe 243, the jack that muffler 25 and extension 233 are inserted into, air inlet pipe 243, muffler 25 and extension 233 distinguish seamless welding In a jack.
Alternatively embodiment, no setting is required the rear end of back segment instlated tubular 22 aft bulkhead, in back segment instlated tubular 22 Rear end directlys adopt seamless between air inlet pipe 243, the outer wall of muffler 25 and extension 233 and the inner wall of back segment instlated tubular 22 Gap is welded and fixed, i.e., the outer wall and back segment instlated tubular 22 of air inlet pipe 243, muffler 25 and extension 233 are filled up by solder Gap between inner wall.
Air inlet pipe 243 and the structure placed side by side in 22 rear end welded seal of back segment instlated tubular of muffler 25 are suitable for return-air The lower cryoablation needle of temperature.
Figure 12 to Figure 14 is please referred to, alternatively embodiment, the back-end sealing component 23 is back-end sealing circle group Part, the back-end sealing coil assembly are built in the back segment inner tube 222, and the mandrel 11 passes through the back-end sealing coil assembly And it is connect with the back-end sealing coil assembly dynamic sealing.In the present embodiment, the rear end of the back segment inner tube 222 of back segment instlated tubular 22 Be flared and with 221 vacuum welding of back segment outer tube, back segment inner tube 222 rear end flaring with back segment outer tube 221 weld after and continue to Extend afterwards to guarantee that there is enough spaces to be put into back-end sealing circle 231 and back-end sealing circle gear for the rear end of back segment inner tube 222 Plate 232.In the present embodiment, back-end sealing component 23 includes two back-end sealing circle baffles 232 and back-end sealing circle 231, after one The flaring of sealing ring baffle 232 and back segment inner tube 222 is held to weld, two back-end sealing circle baffles 232 are threadedly engaged to fix rear end Sealing ring 231, two back-end sealing circle baffles 232 can be connected by way of screw threads for fastening, between two back-end sealing circle baffles 232 An inner groovy is formed, the fixation of back-end sealing circle 231 is embedded on this inner groovy, and the mandrel 11 passes through the back-end sealing circle It 231 and is connect with its dynamic sealing.
In the present embodiment, back-end sealing component 23 is filled in the back segment flaring of back segment inner tube 222 and is welded, which has Help reduce the length of handle 26.
In the present embodiment, it offers two fairleads 2321 on back-end sealing circle baffle 232, the air inlet pipe 243 and returns Tracheae 25 is respectively welded in a fairlead 2321.
In the present invention, directly regulating member 1 can be operated manually, moves it can relative to fixation member 2, Regulating member 1 can also be operated indirectly by adjusting driving lever, the present invention is not particularly limited this, and the present embodiment is with the It is described in detail for two kinds of embodiments, specific structure is as follows:
Regulating member 1 further includes an adjusting sleeve pipe 14, and the adjusting sleeve pipe 14 is coated at back segment instlated tubular 22, in this implementation In example, the rear end face of adjusting sleeve pipe 14 is located at the rear of back segment instlated tubular 22, and the side wall of adjusting sleeve pipe 14 is equipped with driving lever 143, The rear end face of the adjusting sleeve pipe 14 is equipped with the guidance window 141 passed through for air inlet pipe 243 and muffler 25 and mandrel company Hole 142 is connect, mandrel 11 passes through mandrel connecting hole 142, and is fixedly connected with mandrel connecting hole 142, and the mode of being fixedly connected can be used Welding is threadedly coupled.Driving lever 143 adjusts the length of targeting district 3 for stirring regulating member 1 forward or backward with hand.
In the present embodiment, the fixation member 2 further includes handle 26, handle 26 is fixed be set in the shank 21 or/ On back segment instlated tubular 22, adjusting sleeve pipe 14 is in the gap between handle 26 and back segment instlated tubular 22, the side of handle 26 Equipped with regulating tank 261, driving lever 143 is stretched out from the regulating tank 261, it is therefore an objective to be stirred convenient for manpower.Handle 26 is not subject to any next From the pressure inside needle.
It in the adjustment process of targeting district 3, is adjusted before and after stirring driving lever 143 by hand, driving lever 143 will drive entire adjusting Component 1 carries out piston motion, and J-T slot 241 and mandrel 11, will not be because of different from syringe needle due to having certain flexibility The problem of heart and lead to not adjust.The rear end section of adjusting sleeve pipe 14 as shown in figure 8, air inlet pipe 243 and muffler 25 from drawing It leads window 141 to pass through, ensure that the air inlet pipe 243 for fixing position in adjustment process and muffler 25 will not be caused to component is adjusted It hinders.It is entire to adjust component relative to 2 position of fixation member near preceding when being adjusted to most short targeting district 3, it is formed by targeting 3 length of area is most short, and ice hockey caused by corresponding freezing is also minimum;When being adjusted to longest targeting district 3, it is entire adjust component relative to 2 position of fixation member is formed by 3 length longest of targeting district near rear, it is corresponding freeze caused by ice hockey it is maximum.
Embodiment 2
Figure 15 and Figure 16 are please referred to, when the suction temperature of cryoablation needle is less low, muffler 25 can be coated at air inlet Pipe 243, Figure 11 are the rear structure of the adjustable targeting district 3 of the type cryoablation needle, the structure not shown in figure and Fig. 9, figure 10 is consistent.The rear end of the back segment inner tube 222 of the structure is opening-wide state, only need to be by air inlet pipe 243 and the fixed company of back segment inner tube 222 It connects, 25 sets of the muffler rear portions in handle 26, air inlet pipe 243 is located inside muffler 25.The back-end sealing group of the structure Part 23 is back-end sealing coil assembly, this rear end seal ring assembly is fixed on the outside of the rear end of back segment instlated tubular 22, the back segment every It is connected between heat pipe 22 and the adjusting sleeve pipe 14 by the back-end sealing coil assembly dynamic sealing.
Further, the back-end sealing coil assembly include two back-end sealing circle baffles 232 and back-end sealing circle 231, one The back-end sealing circle baffle 232 is fixed on the outer wall of the back segment instlated tubular 22, the two back-end sealing circle baffles 232 cooperations by the fixation back-end sealing circle 231 (two back-end sealing circle baffles 232 can by screw threads for fastening in a manner of connect, An external groove is formed between two back-end sealing circle baffles 232, the fixation of back-end sealing circle 231 is embedded in this external groove), after described End sealing ring 231 is contacted with the inner wall of the adjusting sleeve pipe 14 and is connect with its dynamic sealing.Back-end sealing circle 231 and adjusting set The interior side contacts of pipe 14 prevent gap of the return-air between adjusting sleeve pipe 14 and back segment instlated tubular 22 from escaping forward.In this implementation In example, the rear end face of adjusting sleeve pipe 14 is located at the rear of back segment instlated tubular 22, and 14 rear end face of adjusting sleeve pipe of the structure also includes Guidance window 141 and mandrel connecting hole 142, mandrel 11 be fixed in wherein mandrel connecting hole 142, air inlet pipe 243 from guidance window Mouth 141 passes through.Further, since the suction temperature of the type cryoablation needle is less low, the program can single layer tube wall, i.e., only retain Back segment inner tube 222, removes back segment outer tube 221, and the heat preservation that 26 sections of handle only relies between adjusting sleeve pipe 14 and back segment inner tube 222 Gap realize.
Embodiment 3
For the working condition of real-time monitoring cryoablation needle and the central temperature in freezing region, cryoablation needle needs to have Real-time temperature measuring function inside standby targeting district.As shown in figure 17, the lead-out mode of thermometric line 271 can be by between finned tube 242 Gap is drawn, and the fixation member 22 of the program also includes wire component 27, and wire component 27 includes thermometric line 271 and electric wire fairlead 272, the temperature measuring point 2711 of thermometric line 271 is placed in the front end of J-T slot 241, and thermometric line 271 successively passes through leading portion inner tube 122 Inside, return-air slot 1331, finned tube 242 (finned tube 242 is wound on mandrel 11 with certain screw pitch, thermometric line in gap 271 do not penetrate in the pipe of finned tube 242, but pass through out of spiral 242 coiling of finned tube cylinder) and electric wire fairlead 272 draw outside needle, wherein fill glue inside electric wire fairlead 272, while to guarantee that it draws thermometric line 271, in needle Gas will not be leaked to outside needle by electric wire fairlead 272.Electric wire fairlead 272 and air inlet pipe 243, muffler 25 and rear end are close Sealing assembly 23 is welded in the rear end face of back segment inner tube 222, and four (electric wire fairlead 272, air inlet pipe 243, mufflers 25 together With back-end sealing component 23) it is that isolating seal is arranged that (purpose is to prevent return-air from the rear end face of back segment inner tube 222 between each other Escape forward), and electric wire fairlead 272 and air inlet pipe 243 and muffler 25 pass through guidance window 141 together.Program structure It is more complex, but the position of temperature measuring point 2711 is fixed, and is not changed with the adjusting of targeting district.Realize cryoablation needle rewarming function The lead-out mode of rewarming line is consistent with the lead-out mode of thermometric line 271.
Embodiment 4
Thermometric line 271 can also be drawn outside needle by mandrel 11, and as shown in figure 18, wire component 27 of the program include A piece thermometric line 271, belongs to a part of regulating member 1.The mandrel 11 of the program is hollow tubular product, the survey of thermometric line 271 Warm spot 2711 is placed in the front end of leading portion inner tube 122, thermometric line 271 successively by inside leading portion inner tube 12, intermediate connection tube 133 Internal and mandrel 11 is drawn outside needle, glue is filled inside mandrel 11, to prevent gas leakage in needle.The program is simple for structure, but Temperature measuring point 2711 can change with the adjusting of targeting district, and targeting section length is longer, temperature and the targeting district 3 of temperature measuring point 2711 Central temperature gap is bigger.Realize the lead-out mode of the rewarming line of cryoablation needle rewarming function and the extraction side of thermometric line 271 Formula is consistent.
Embodiment 5
The tumour of pairing approximation spherical shape or elliposoidal can select suitable targeting section length carry out freezing according to its size and disappear Melt, but in actual clinical, the shape of tumour is often irregular, such as " pears " shape tumour that the big tail end of head end is small, for " pears " shape Tumour, can be used in clinic at this stage it is single the cryoablation needle of long targeting district is melted on a large scale, in this way can be at " pears " The circle of middle part one damage more normal tissue, can also front and back place two short targeting districts the freezing of cryoablation needle it is different when Between realize ablation, but will increase the expense and difficulty of operation in this way.If, can be with using the cryoablation needle of adjustable targeting district Realize single accurate conformal ablation needle.Figure 19 is the stream that " pears " shape tumour cryoablation is realized using most short and longest targeting district Journey embodiment: syringe needle is inserted into from the tail end of " pears " shape tumour 5 (range shown in fine dotted line) up to needle point reaches the head end of tumour Inside adjusts targeting district to shortest length, and after opening freezing a period of time, ice hockey 6 (range shown in heavy line) will be freezed tentatively The head end of tumour.Then targeting district is adjusted to maximum length, continues to freeze, ice hockey 6 will freeze the head end and tail of tumour simultaneously End, final 6 shape of ice hockey is by conformal covering " pears " shape tumour 5.
The above disclosure is just a few specific examples of the present application, however, this application is not limited to this, any this field Technical staff can think variation, should all fall in the protection domain of the application.

Claims (17)

1. a kind of cryoablation needle of adjustable targeting district, which is characterized in that described including regulating member (1) and fixation member (2) Regulating member (1) can be axially moved to adjust the length of targeting district (3) relative to the fixation member (2):
The fixation member (2) includes shank (21), back segment instlated tubular (22), air inlet pipe fitting (24) and muffler (25), described The rear end of shank (21) is fixedly connected with the front end of the back segment instlated tubular (22), the shank (21) and the back segment instlated tubular (22) it communicates and forms accommodating cavity;The air inlet pipe fitting (24) and muffler (25) are from the rear end of the back segment instlated tubular (22) It is inserted into the accommodating cavity;
The regulating member (1) includes leading portion instlated tubular (12) and mandrel (11), and the leading portion instlated tubular (12), which slides axially, to be set Set the length that targeting district (3) are adjusted in the accommodating cavity;The air inlet pipe fitting (24) passes through the leading portion instlated tubular (12) And it extends in shank (21);The mandrel (11) is from the insertion of the rear end of the back segment instlated tubular (22) and heat-insulated with the leading portion Manage (12) linkage.
2. the cryoablation needle of adjustable targeting district as described in claim 1, which is characterized in that the shank (21) is coated at institute It states on leading portion instlated tubular (12), passes through between the outer wall of the leading portion instlated tubular (12) and the inner wall of the back segment instlated tubular (22) Forward end seal component (13) the dynamic sealing connection.
3. the cryoablation needle of adjustable targeting district as claimed in claim 2, which is characterized in that the forward end seal component (13) Including forward end seal coil assembly and intermediate connection tube (133), the forward end seal coil assembly is arranged in the leading portion instlated tubular (12) between the inner wall of outer wall and the back segment instlated tubular (22);The front end of the intermediate connection tube (133) and the leading portion Instlated tubular (12) is fixedly connected and communicates, and rear end is fixedly connected with the mandrel (11).
4. the cryoablation needle of adjustable targeting district as claimed in claim 3, which is characterized in that the forward end seal coil assembly packet Front end gear sealing ring baffle and forward end seal circle are included, the forward end seal circle baffle fixing sleeve is set to the intermediate connection tube (133) front end or/and leading portion instlated tubular (12) rear end, the forward end seal circle baffle, which is equipped with, accommodates the forward end seal circle Groove, the forward end seal circle is fixed in this groove.
5. the cryoablation needle of adjustable targeting district as described in claim 1, which is characterized in that the back segment instlated tubular (22) Internal diameter is greater than the internal diameter of the shank (21).
6. the cryoablation needle of adjustable targeting district as claimed in claim 3, which is characterized in that the air inlet pipe fitting (24) includes J-T slot (241), finned tube (242) and air inlet pipe (243), the both ends of the finned tube (242) respectively with the J-T slot (241) It is fixedly connected and communicates with air inlet pipe (243), the finned tube (242) is wound on the mandrel (11) outside;
It is offered return-air slot (1331) on the tube wall of the intermediate connection tube (133), the J-T slot (241) is returned from described in extroversion The front end of the shank (21) is pierced into the leading portion instlated tubular (12) and extended in air drain (1331).
7. the cryoablation needle of adjustable targeting district as described in claim 1, which is characterized in that the fixation member (2) is also wrapped It includes back-end sealing component (23), passes through the back-end sealing component between the mandrel (11) and the back segment instlated tubular (22) (23) dynamic sealing connects.
8. the cryoablation needle of adjustable targeting district as claimed in claim 7, which is characterized in that the back segment seal ring assembly packet Two back-end sealing circle baffles (232) and back-end sealing circle (231) are included, a back-end sealing circle baffle (232) is fixed at On the inner wall of the back segment instlated tubular (22), two back-end sealing circle baffle (232) cooperations are with the fixation back-end sealing circle (231), the mandrel (11) passes through the back-end sealing circle (231) and connect with its dynamic sealing;
It is also provided with two fairleads (2321) on the back-end sealing circle baffle (232), the air inlet pipe (243) and muffler (25) it is individually fixed in a fairlead (2321).
9. the cryoablation needle of adjustable targeting district as claimed in claim 7, which is characterized in that the back-end sealing component (23) Including back-end sealing coil assembly and extension (233), the fixed connection in the front end of the extension (233) is in the back segment instlated tubular (22) rear end face, in the rear end of the extension (233), the mandrel (11) passes through institute for the back-end sealing coil assembly setting It states extension (233) and is connect with the back-end sealing coil assembly dynamic sealing.
10. the cryoablation needle of adjustable targeting district as claimed in claim 7, which is characterized in that the back segment instlated tubular (22) Rear end face also open up two fairleads (2321), the air inlet pipe (243) and muffler (25) are individually fixed in an extraction In hole (2321).
11. the cryoablation needle of adjustable targeting district as claimed in claim 9, which is characterized in that the back-end sealing coil assembly Including two back-end sealing circle baffles (232) and back-end sealing circle (231), a back-end sealing circle baffle (232) is installed in institute The rear end of extension (233) is stated, two back-end sealing circle baffle (232) cooperations are with the fixation back-end sealing circle (231), institute Mandrel (11) are stated across the back-end sealing circle (231) and are connect with its dynamic sealing.
12. the cryoablation needle of adjustable targeting district as described in claim 1, which is characterized in that the regulating member (1) is also wrapped It includes an adjusting sleeve pipe (14), the back segment instlated tubular (22), the adjusting sleeve pipe (14) is sheathed on outside the adjusting sleeve pipe (14) A upper fixed driving lever (143), the rear end of the adjusting sleeve pipe (14) offer guidance window (141) and mandrel connecting hole (142), The mandrel (11) passes through the mandrel connecting hole (142) and is fixedly connected with the mandrel connecting hole (142).
13. the cryoablation needle of adjustable targeting district as claimed in claim 12, which is characterized in that the fixation member (2) is also Including handle (26), handle (26) fixation is set on the shank 21 or/and back segment instlated tubular 22, the adjusting sleeve pipe (14) in the gap between the handle (26) and the back segment instlated tubular (22), the handle (26) is equipped with regulating tank (261), driving lever (143) is stretched out from the regulating tank (261).
14. the cryoablation needle of adjustable targeting district as claimed in claim 13, which is characterized in that the fixation member (2) is also Including back-end sealing component (23), the back-end sealing component (23) includes back-end sealing coil assembly, muffler (25) set It is located at the rear end of the handle (26), the air inlet pipe (243) is located in the muffler (25), the back segment instlated tubular (22) It is connect between the adjusting sleeve pipe (14) by the back-end sealing coil assembly dynamic sealing.
15. the cryoablation needle of adjustable targeting district as claimed in claim 14, which is characterized in that the back-end sealing coil assembly Including two back-end sealing circle baffles (232) and back-end sealing circle (231), back-end sealing circle baffle (232) fixed setting On the outer wall of the back segment instlated tubular (22), two back-end sealing circle baffle (232) cooperations are with the fixation back-end sealing It encloses (231), the back-end sealing circle (231) contacts with the inner wall of the adjusting sleeve pipe (14) and connect with its dynamic sealing.
16. the cryoablation needle of adjustable targeting district as claimed in claim 6, which is characterized in that the fixation member (2) is also wrapped It includes wire component (27), the wire component (27) includes thermometric line (271) and electric wire fairlead (272), and the electric wire is drawn Pipe (272) is fixed on the rear end of the back segment instlated tubular (22), the thermometric line (271) sequentially pass through leading portion instlated tubular (12), Return-air slot (1331), the gap of finned tube (242) and electric wire fairlead (272) are drawn outside needle, the thermometric of the thermometric line (271) Point (2711) is located at the leading portion of the J-T slot (241).
17. the cryoablation needle of adjustable targeting district as claimed in claim 3, which is characterized in that the regulating member (1) is also wrapped Include thermometric line (271), the mandrel (11) be hollow tubular product, the thermometric line (271) sequentially pass through leading portion instlated tubular (12), in Between connecting tube (133), mandrel (11) lead to outside needle, the temperature measuring point (2711) is located at the front end of leading portion instlated tubular (12).
CN201910752750.7A 2019-08-13 2019-08-13 The cryoablation needle of adjustable targeting district Pending CN110507405A (en)

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CN113768610A (en) * 2021-11-11 2021-12-10 上海导向医疗***有限公司 Cryoablation needle with adjustable vacuum wall position
CN114010303A (en) * 2021-11-11 2022-02-08 上海市胸科医院 Cryoablation needle of J-T groove sleeve
CN114601554A (en) * 2022-05-10 2022-06-10 上海导向医疗***有限公司 Ablation needle and ablation system
WO2023083050A1 (en) * 2021-11-11 2023-05-19 上海导向医疗***有限公司 J-t slot position-adjustable cryoablation needle
CN116350337A (en) * 2023-05-30 2023-06-30 海杰亚(北京)医疗器械有限公司 Cold and hot ablation needle and ablation system
CN117883173A (en) * 2024-03-11 2024-04-16 海杰亚(北京)医疗器械有限公司 Simple cold and hot ablation needle and ablation device

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CN113768610A (en) * 2021-11-11 2021-12-10 上海导向医疗***有限公司 Cryoablation needle with adjustable vacuum wall position
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