CN110491765A - A kind of control method of ion mobility spectrometry intermediate ion door - Google Patents
A kind of control method of ion mobility spectrometry intermediate ion door Download PDFInfo
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- CN110491765A CN110491765A CN201811412006.4A CN201811412006A CN110491765A CN 110491765 A CN110491765 A CN 110491765A CN 201811412006 A CN201811412006 A CN 201811412006A CN 110491765 A CN110491765 A CN 110491765A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
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- H—ELECTRICITY
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- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
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- H01J49/26—Mass spectrometers or separator tubes
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Abstract
The present invention discloses a kind of new method for controlling Bradbury-Nielsen type ion gate in ion mobility spectrometry.The electrode voltage that this method passes through adjusting ion gate, on the one hand inhomogeneous field is made full use of to roll into a ball the resolution capability for carrying out time-space compression and improving ion mobility spectrometry to the migration area IMS intermediate ion, on the other hand, ion gate shutdown voltage can be effectively reduced and be formed by the consumption that ion mobility spectrometry migration area intermediate ion is rolled into a ball in ion keep-out region, improve IMS detection sensitivity.The method of the present invention is simple, without carrying out hardware modifications to transference tube.
Description
Technical field
The present invention relates to the voltage control method of ion mobility spectrometry significant components ion gate, specifically one kind passes through control
The electrode voltage of ion gate processed, while the method for improving ion mobility spectrometry resolution capability and detection sensitivity.
Background technique
The ion gate that transit time ion mobility spectrometry (Ion Mobility Spectrometry, IMS) needs the period to open
Ion cluster is injected into ion migration zone realizes its separation and detection to object ion.The time that ion gate injects ion cluster is wide
Degree and total ion concentration determine the resolution capability (Resolving Power, R) and detection sensitivity of ion mobility spectrometry.
The IMS fixed for migration section length L, R is by ion gate opening time winjAnd peak exhibition caused by ion cluster migration
Width (16kBTln2/eUd)1/2(L2/KUd) determine, as shown in formula 1.When instrument parameter is fixed, peak caused by ion cluster migrates
Broadening immobilizes, ion gate opening time winjJust at the sole determinant of R: winjSmaller, R is higher.
Wherein, L is Ion transfer section length, and K is ionic mobility (K=K0(T/273.5) (760/P), T are temperature, P
For pressure), UdFor migration area total voltage, tdFor quasi-molecular ions transit time, w0.5For quasi-molecular ions half-peak breadth, winjFor ion gate enabling
Time, 16kBTln2/eUdPeak stretching coefficient is caused for ion diffusion.
Bradbury-Nielsen type ion gate (BNG) is the ion gate structure generallyd use in current commercialization IMS instrument
Type.BNG is formed using two groups of wires of coplanar placement and is realized ion cluster with the perpendicular radial electric field in Ion transfer direction
It cuts.Since BNG mechanical structure thickness can almost ignore (string diameter equal to BNG is typically≤0.1mm), it is generally considered
It is that optimal ion cuts tool: ion piece may be implemented in time-domain (winj) any scale rectangle cut, it can pass through
Reduce winjObtain high IMS resolution capability.
However, 2012, influence of the Dalian Chemistry and Physics Institute Li Haiyang professor in research BNG shutdown voltage to IMS resolution capability
Shi Faxian: BNG at closing time, and shutdown electric field can be permeated towards with the adjacent ion migration zone BNG and ionic reaction area direction.It closes
Door electric field causes the electric field in migration area close to ion gate region instantaneously to enhance towards the infiltration of migration area, to by BNG from
Son group is in time-domain winjOn compressed so that the actually detected half-peak breadth to quasi-molecular ions of IMS narrows, improve the resolution energy of IMS
Power[11]；In addition, the infiltration of shutdown electric field causes the two sides BNG to generate apparent ion keep-out region simultaneously, axial depth is much larger than
The string diameter of BNG, with silk spacing quite (when typically, silk spacing is 1mm, ion keep-out region mean depth reaches 1.1mm).One side
Face, in BNG opening time winjIt is interior, it only just can enter in ion migration zone by the ion of ion keep-out region and separated and examined
It surveys, causes the real time width of the BNG injection migration area IMS intermediate ion group to be far smaller than the opening time of BNG, reduce IMS
The sensitivity of detection；On the other hand, after BNG opening time, BNG shutdown electric field closes on the migration area IMS side shape in BNG
At ion keep-out region the ion that a part comes into the migration area IMS can be retracted again and consumed on the electrode of BNG, into one
Step reduces the sensitivity of IMS detection.
The present invention will announce a kind of new method for controlling BNG gate electrode voltage, and inhomogeneous field is made full use of to migrate IMS
Intermediate ion group in area's carries out time-space compression and improves the resolution capability of IMS, while reducing the ion keep-out region pair of BNG shutdown voltage formation
The consumption of the migration area IMS intermediate ion group, improves IMS detection sensitivity.
Summary of the invention
The object of the present invention is to provide a kind of new methods for controlling BNG gate electrode voltage, make full use of inhomogeneous field pair
Intermediate ion group in the migration area IMS carries out time-space compression and improves the resolution capability of IMS, while reducing the ion of BNG shutdown voltage formation
The consumption that the migration area IMS intermediate ion is rolled into a ball in keep-out region improves IMS detection sensitivity.
To achieve the goals above, the technical solution adopted by the present invention are as follows:
A kind of control method of ion mobility spectrometry intermediate ion door, the ion mobility spectrometry includes transference tube, and ion moves
Pipe is moved to be made of ion source, ionized region, ion gate, migration area and the ion receiving pole being sequentially placed from left to right.
Ion gate is located between the ionized region and right side migration area in left side.
By 4 or more strip shaped electric poles, parallel interval setting is constituted ion gate from top to bottom, from top to bottom, the strip electricity of odd number
Pole is as the first gate electrode, and the strip shaped electric poles of even number are as the second gate electrode.
It is constituted or, being spaced setting from the inside to the outside with geometric center by the ring electrode of same geometric center；From the inside to the outside, odd number
Ring electrode as the first gate electrode, the ring electrode of even number is as the second gate electrode.
First gate electrode and the second gate electrode are connected with two pulse direct current high voltage power supplies respectively.
By the time interval length of the first preset period of time, the time interval length of the second preset period of time, third preset period of time
Time interval length successively in applying voltage on the first gate electrode, the second gate electrode.
In the time interval length of the first preset period of time, apply the first electricity on the first gate electrode, the second gate electrode simultaneously
Pressure forms in transference tube and is directed toward the DC electric field that ion receives extreme direction along ion source, the ion in ionized region pass through from
Cervical orifice of uterus enters in migration area.
Apply simultaneously in the time interval length of the second preset period of time, the first gate electrode, the second gate electrode and is higher than first
The second voltage of voltage forms the DC electric field that ion source direction is directed toward along ion gate, electricity in the ionized region of transference tube
It is moved from the ion in area towards ion source direction, is formed in the migration area of transference tube and be directed toward ion reception along ion gate
The DC electric field of extreme direction gradually weakened receives polar motion into the ion in migration area towards ion.
Apply first voltage, same on the second gate electrode in the time interval length of third preset period of time, the first gate electrode
When apply be higher than first voltage tertiary voltage, tertiary voltage be lower than second voltage, formed in the ionized region of transference tube
The DC electric field in ion gate direction is directed toward along ion source, the ion in ionized region is moved towards ion gate direction, in first electricity
The electric field perpendicular to transference tube axial direction is formed between pole and the second gate electrode, and the ion in ionized region is prevented to pass through ion gate
Into in migration area, is formed in the migration area of transference tube and is directed toward the DC electric field that ion receives extreme direction along ion gate,
Ion in migration area successively reaches ion receiving pole under the action of DC electric field and is detected.
Strip shaped electric poles are wire or the zigzag shape electrode or sheet metal or metal mesh sheet that are wound on cylindrical body.
Ring electrode is circular ring electrode or square ring electrode.
The value of first prefixed time interval between 0.001ms~0.2ms, the value of the second prefixed time interval between
Between 0.001ms~1ms, the value of third prefixed time interval is between 0.2ms~10ms；With the first prefixed time interval,
The adduction of second prefixed time interval and third prefixed time interval constitutes a complete time period of ion gate work.
Ion gate is constituted with the adduction of the first prefixed time interval, the second prefixed time interval and third prefixed time interval
One complete time period of work
When transference tube works, the voltage applied on the first gate electrode and the second gate electrode of ion gate is according to described
Time cycle carries out periodic cycle adjusting.
It is an advantage of the invention that
The present invention can be achieved ion mobility spectrometry resolution capability it is synchronous with detection sensitivity improve, method is simple, be not necessarily to pair
Transference tube carries out hardware modifications.
Detailed description of the invention
Fig. 1, the transference tube for being internally provided with Bradbury-Nielsen type ion gate.Wherein: 1 --- ion source；
2 --- ionized region；3 --- Bradbury-Nielsen type ion gate；3-1 --- the first gate electrode；3-2 --- second electricity
Pole；4 --- migration area；5 --- ion receiving pole；6 --- drift gas air inlet；7 --- sample gas air inlet；8 --- outlet
Mouthful.
Fig. 2, the voltage control sequential figure disclosed by the invention for Bradbury-Nielsen type ion gate in Fig. 1.Its
In, the voltage of the first gate electrode 3-1 is in V0And V2Between change, the voltage of the voltage of the second gate electrode 3-2 is in V0、V1And V2Between
Change, wherein t1=0.04ms, t2=0.2ms, t3=10ms, V0=5910V, V1=6010V, V2=6910V.
The conventional use of voltage control sequential figure of Bradbury-Nielsen type ion gate in Fig. 3, Fig. 1.Wherein, first
The constant voltage of electrode 3-1 is V0, the voltage of the voltage of the second gate electrode 3-2 is in V0And V1Between change, wherein t1=
0.04ms, t2=0.2ms, t3=10ms, V0=5910V, V1=6010V.
Fig. 4, two kinds of different voltages control sequentials obtain the ion transfer spectrogram comparison of 50ppb DMMP.
Specific embodiment
The invention will now be described in further detail with reference to the accompanying drawings.
Embodiment 1
Transference tube using Bradbury-Nielsen type ion gate is as shown in fig. 1.The ion of transference tube
Source 1 uses63Ni, 2 length of ionized region are 20mm, 2 electric field strength 60V/mm of ionized region, 4 length 96mm of migration area, 4 electricity of migration area
Field intensity 60V/cm；Ion gate 3 is made of the wire electrode of the first gate electrode 3-1 and second two groups of mutually insulateds of gate electrode 3-2,
String diameter 0.1mm, silk spacing 1mm.
In the first prefixed time interval t1In=0.04ms, 3-2 applies simultaneously on the first gate electrode 3-1, the second gate electrode
First voltage V0=5910V is formed in transference tube and is directed toward the DC electric field that ion receives extreme direction, ionization along ion source
Ion in area enters in migration area through ion gate.
The t in the second prefixed time interval23-2 applies the simultaneously on=0.2ms, the first gate electrode 3-1, the second gate electrode
Two voltage V2=6910V forms the DC electric field that ion source direction is directed toward along ion gate, electricity in the ionized region of transference tube
It is moved from the ion in area towards ion source direction, is formed in the migration area of transference tube and be directed toward ion reception along ion gate
The DC electric field of extreme direction gradually weakened receives polar motion into the ion in migration area towards ion.
The t in third prefixed time interval3Apply first voltage V on=10ms, the first gate electrode 3-10=5910V, second
Apply tertiary voltage V on gate electrode on 3-21=6010V is formed in the ionized region of transference tube and is directed toward ion along ion source
The DC electric field in door direction, the ion in ionized region are moved towards ion gate direction, the first gate electrode and the second gate electrode it
Between formed perpendicular to transference tube axial direction electric field, prevention ionized region in ion entered in migration area by ion gate, In
It is formed in the migration area of transference tube and is directed toward the DC electric field that ion receives extreme direction along ion gate, the ion in migration area exists
Ion receiving pole is successively reached under the action of DC electric field to be detected.
First preset time t1=0.04ms, the second prefixed time interval t2=0.2ms, third prefixed time interval t3=
10ms adduction is the complete time period that t=10.24ms constitutes ion gate work.
When transference tube works, the voltage that is applied on ion gate the first gate electrode 3-1 and the second gate electrode 3-2 according to
The voltage change timing provided in Fig. 2 is in mechanical periodicity by the period of 10.24ms.
Embodiment 2
Fig. 4 b illustrates the 50ppb DMMP's obtained under BNG ion gate voltage control sequential shown in Fig. 2 in Fig. 1
Spectrogram, wherein the resolution capability of acetone dimer is 118, signal strength 450pA；The resolution capability of DMMP is 108, and signal is strong
Degree is 160pA.
Embodiment 3
For the advantage of BNG ion gate gate voltage control sequential shown in comparison diagram 2, the BNG ion gate also obtained is normal
The spectrogram of 50ppb DMMP (shown in Fig. 3) under gate voltage control sequential is advised, wherein the resolution capability of acetone dimer is 80, letter
Number intensity is 140pA；Apparent DMMP ion signal is not observed.
Claims (4)
1. a kind of control method of ion mobility spectrometry intermediate ion door, the ion mobility spectrometry include transference tube, Ion transfer
Pipe is made of ion source, ionized region, ion gate, migration area and the ion receiving pole being sequentially placed from left to right, it is characterised in that:
The ion gate is located between the ionized region and right side migration area in left side；
By 4 or more strip shaped electric poles, parallel interval setting is constituted ion gate from top to bottom, and from top to bottom, the strip shaped electric poles of odd number are made
For the first gate electrode, the strip shaped electric poles of even number are as the second gate electrode；
It is constituted or, being spaced setting from the inside to the outside with geometric center by the ring electrode of same geometric center；From the inside to the outside, the ring of odd number
Shape electrode is as the first gate electrode, and the ring electrode of even number is as the second gate electrode；
First gate electrode and the second gate electrode are connected with two pulse direct current high voltage power supplies respectively；
By the time interval length of the first preset period of time, the time interval length of the second preset period of time, third preset period of time when
Between gap length successively in applying voltage on the first gate electrode, the second gate electrode；
In the time interval length of the first preset period of time, apply first voltage, In on the first gate electrode, the second gate electrode simultaneously
Formed in transference tube and be directed toward the DC electric field that ion receives extreme direction along ion source, the ion in ionized region through ion gate into
Enter in migration area；
Apply simultaneously in the time interval length of the second preset period of time, the first gate electrode, the second gate electrode and is higher than first voltage
Second voltage, in the ionized region of transference tube formed along ion gate be directed toward ion source direction DC electric field, ionized region
In ion towards ion source direction move, in the migration area of transference tube formed along ion gate be directed toward ion receiving pole side
To the DC electric field gradually weakened, into the ion in migration area towards ion receive polar motion；
Apply first voltage in the time interval length of third preset period of time, the first gate electrode, applied on the second gate electrode simultaneously
Increase the tertiary voltage in first voltage, tertiary voltage is lower than second voltage, formed in the ionized region of transference tube along from
Component is directed toward the DC electric field in ion gate direction, and the ion in ionized region is moved towards ion gate direction, the first gate electrode with
The electric field perpendicular to transference tube axial direction is formed between second gate electrode, and the ion in ionized region is prevented to enter by ion gate
In migration area, is formed in the migration area of transference tube and be directed toward the DC electric field that ion receives extreme direction, migration along ion gate
Ion in area successively reaches ion receiving pole under the action of DC electric field and is detected.
2. the control method of ion mobility spectrometry intermediate ion door according to claim 1, it is characterised in that:
Strip shaped electric poles are wire or the zigzag shape electrode or sheet metal or metal mesh sheet that are wound on cylindrical body.
Ring electrode is circular ring electrode or square ring electrode.
3. control method according to claim 1, it is characterised in that:
The value of first prefixed time interval between 0.001ms~0.2ms, the value of the second prefixed time interval between
Between 0.001ms~1ms, the value of third prefixed time interval is between 0.2ms~10ms；With the first prefixed time interval,
The adduction of second prefixed time interval and third prefixed time interval constitutes a complete time period of ion gate work.
4. control method according to claim 1 or 3, it is characterised in that: with the first prefixed time interval, second it is default when
Between interval and third prefixed time interval adduction constitute ion gate work a complete time period
When transference tube works, the voltage applied on the first gate electrode and the second gate electrode of ion gate is according to the time
Period carries out periodic cycle adjusting.
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Cited By (2)
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| CN112331550A (en) * | 2020-11-17 | 2021-02-05 | 辽宁警察学院 | Ion gate for ion mobility spectrometer and control method thereof |
| CN112820621A (en) * | 2020-12-29 | 2021-05-18 | 中船重工安谱（湖北）仪器有限公司 | Multi-ion gate migration tube and multi-ion gate compression type control method |
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