CN110475483A - 制备包含阿魏酸的组合物的方法 - Google Patents
制备包含阿魏酸的组合物的方法 Download PDFInfo
- Publication number
- CN110475483A CN110475483A CN201880018727.9A CN201880018727A CN110475483A CN 110475483 A CN110475483 A CN 110475483A CN 201880018727 A CN201880018727 A CN 201880018727A CN 110475483 A CN110475483 A CN 110475483A
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- Prior art keywords
- bran
- mixture
- composition
- weight
- wheat bran
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01073—Feruloyl esterase (3.1.1.73)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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Abstract
本发明涉及制备包含阿魏酸的组合物的方法。本发明的一个方面是用于治疗或预防代谢疾病的包含水解小麦麸皮的组合物。
Description
技术领域
本发明涉及制备包含阿魏酸的组合物的方法。本发明的一个方面是用于治疗或预防代谢疾病的包含水解小麦麸皮的组合物。
背景技术
麸皮与胚芽一起作为整粒谷物的整体部分,由具有潜在健康有益效果的宽泛范围的化合物(纤维、维生素、矿物质和植物素)组成。阿魏酸(FA)是已知具有许多生理功能的麸皮的组分。然而,FA主要结合到细胞壁多糖,因此其在麸皮中的生物利用率非常低。Faulds[C.B.Faulds等人,Appl.Microbiol.Biotechnol.,64:644-650(2004)]描述了从小麦麸皮获得FA的方法,该方法涉及通过醇提取去除麸皮中的淀粉,然后用阿魏酸酯酶和来自特异腐质霉(Humicola insolens)的糖基水解酶处理不溶性级分。反应时间为3小时。不进行醇提取时,仅释放0.5mg/g的FA,但进行醇提取时,释放量为2.88mg/g。
有利的是能够提供一种用于从麸皮中释放FA的改善方法,从而理想地避免了需要醇提取步骤。有利的是提供一种可在使用来自天然来源的成分生产食品期间应用于过程中的释放FA的方法。
发明内容
本发明的目的是改进现有技术并提供改善的方法来克服上述困难中的至少一些或至少提供有用的替代形式。本发明的目的通过独立权利要求的主题实现。从属权利要求进一步拓展本发明的构想。不能将本说明书中对现有技术文献的任何参考视为承认此类现有技术为众所周知的技术或形成本领域普遍常识的一部分。如本说明书中所用,词语“包括”、“包含”和类似词语不应理解为具有排他性或穷举性的含义。换句话讲,这些词语旨在意指“包括,但不限于”。
因此,本发明在第一方面提供制备包含阿魏酸的组合物的方法,该方法包括以下步骤:形成包含麸皮和水的麸皮混合物,该混合物具有至少50重量%的水含量并且包含1重量%至50重量%的麸皮;将麸皮混合物加热至介于80℃和150℃之间的温度;将麸皮混合物冷却至低于50℃;以及使麸皮混合物经受酶处理,包括使麸皮混合物与糖酶和阿魏酸酯酶接触。本发明的另一方面涉及一种用于治疗或预防代谢疾病或肥胖症的包含水解小麦麸皮的组合物,其中组合物包含介于0.001重量%和0.25重量%之间的阿魏酸。
本发明人惊奇地发现,在施加酶之前对麸皮进行热预处理导致释放更多FA,例如,在使用相同的酶处理进行热预处理的情况下,释放的FA可能为三倍。热预处理还增加了低分子量可溶性纤维和游离氨基酸的产生,这有助于形成积极的营养特征。此外,热预处理改善了麸皮的可加工性。热预处理预先胶凝化淀粉并使可能存在于麸皮中的内源性酶失活。
附图说明
图1示出了在应用热预处理(A)和不进行热预处理(B)的情况下水解小麦麸皮浆液期间随时间推移(分钟)的阿魏酸(mg游离阿魏酸/g干麸皮)的释放。
具体实施方式
因此,本发明部分地涉及制备包含阿魏酸的组合物的方法,该方法包括以下步骤:a)形成包含麸皮和水的麸皮混合物,该混合物具有至少50重量%的水含量(例如至少70重量%,又如介于75重量%和90重量%之间)并且包含1重量%至50重量%的麸皮(例如包含1重量%至30重量%的麸皮,又如包含介于20重量%和30重量%之间的麸皮);b)将麸皮混合物加热至介于75℃和150℃之间的温度(例如介于80℃和120℃之间,又如介于85℃和115℃之间);c)将麸皮混合物冷却至低于50℃(例如冷却至介于10℃和50℃之间,又如冷却至介于35℃和45℃之间);以及d)使麸皮混合物经受酶处理,包括使麸皮混合物与糖酶和阿魏酸酯酶接触。
阿魏酸或(E)-3-(4-羟基-3-甲氧基-苯基)丙-2-烯酸是存在于咖啡、苹果、洋蓟、花生和橙子的种子中的以及存在于植物(诸如稻、小麦和燕麦)的种子和细胞壁中的羟基肉桂酸。
根据本发明方法的麸皮可以来源于全世界食用的主要谷物:小麦、荞麦、稻米、玉蜀黍、大麦、燕麦、裸麦、小米和高粱。在一个实施方案中,麸皮选自稻米麸皮、小麦麸皮、燕麦麸皮以及它们的组合。优选地,麸皮为小麦麸皮。麸皮可包含在整粒谷物内。整粒谷物是包含胚芽、胚乳和麸皮的谷物粒。整粒谷物可为经研磨的整粒谷物。麸皮是常见的食物配料,消费者接受度高且营养价值高。
根据本发明方法的步骤b加热麸皮混合物可例如进行至少10秒的持续时间。根据本发明方法的步骤b加热麸皮混合物可例如在介于75℃和100℃之间的温度下进行介于2和20分钟之间的持续时间。根据本发明方法的步骤b加热麸皮混合物可通过直接蒸汽喷射进行,麸皮混合物中注入有蒸汽。例如可将麸皮混合物加热至介于100℃和130℃之间的温度,持续时间介于10秒和2分钟之间。
根据本发明的方法的酶处理可包括使麸皮混合物与糖酶(诸如木聚糖酶)和阿魏酸酯酶接触。麸皮混合物可与糖酶和阿魏酸酯酶的混合物形式的糖酶(诸如木聚糖酶)和阿魏酸酯酶接触,或者麸皮混合物可与糖酶和阿魏酸酯酶依次接触。包含糖酶和阿魏酸酯酶的混合物可商购获得。商业酶制剂通常包含酶的混合物,该混合物具有主要功能以及副活性。在本发明方法的一个实施方案中,麸皮混合物可与包含糖酶和阿魏酸酯酶两者的商业酶制剂接触,例如选自DepolTM740L(由Biocatalysts销售)、500BG(由Novozymes销售)、Ultraflow L(由Novozymes销售)、DepolTM453P(由Biocatalysts销售)和绿原酸酯酶(由Kikkoman销售)的酶制剂。在本发明方法的一个实施方案中,麸皮混合物可与混合物形式的糖酶和阿魏酸酯酶接触,其中混合物包含选自DepolTM740L(由Biocatalysts销售)、500BG(由Novozymes销售)、Ultraflow L(由Novozymes销售)、DepolTM453P(由Biocatalysts销售)和绿原酸酯酶(由Kikkoman销售)的酶制剂和选自DepolTM761L(由Biocatalysts销售)、GrindamylTMPowerbake 900(由Danisco销售)、DepolTM453P(由Biocatalysts销售)、Mono BG(由Novozymes销售)、ValidaseTMX(由Valley Research销售)、DepolTM333P(由Biocatalysts销售)和BG(由Novozymes销售)的酶制剂。麸皮混合物可与500BG(由Novozymes销售)和ValidaseTMX(由Valley Research销售)的混合物形式的糖酶和阿魏酸酯酶接触。麸皮混合物可与500BG(由Novozymes销售)接触。虽然主要认为500BG是多组分木聚糖酶,但它也具有阿魏酸酯酶活性。
根据本发明方法的麸皮混合物中的麸皮可包含在整粒谷物中。整粒谷物可从不同来源获得。整粒谷物来源的示例为粗粒、锥粒、碎粒、面粉和微粉化谷物(微粉化面粉)。可优选地通过干磨来研磨整粒谷物。整粒谷物是来自早熟禾科(禾本科)的单子叶植物的谷物,其栽培目的是为了获取可食用淀粉谷粒。整粒谷物的示例包括大麦、稻米、黑米、糙米、野生稻米、荞麦、碎小麦、玉米、小米、燕麦、高粱、斯佩耳特小麦、黑小麦、裸麦、小麦、小麦粒、画眉草、金丝雀虉草、薏米和福尼奥米。不属于禾本科、但也产生可与谷物谷粒以相同方式使用的含淀粉的种子或果实的植物物种被称为假谷物。假谷物的示例包括苋菜、荞麦、鞑靼荞麦和藜麦。在指定谷物时,这将包括谷物和假谷物。
根据本发明方法的麸皮混合物可通过用α淀粉酶酶促水解整粒谷物来形成,所述α淀粉酶在处于活性状态时表现出对膳食纤维无水解活性。术语“对膳食纤维无水解活性”可涵盖至多降解5%的膳食纤维,诸如至多3%,诸如至多2%,以及诸如至多降解1%。如果使用高浓度或较长温育时间,则此类降解可能是不可避免的。用α淀粉酶处理整粒谷物导致其变得不那么粘稠并且更适于包含在多种食物产品中。通过使用对膳食纤维无水解活性的α淀粉酶,整粒谷物的麸皮组分被保留。
麸皮混合物可由包括以下步骤的方法制备:a)使整粒谷物组分与水中的酶组合物接触,该酶组合物包含至少一种α淀粉酶,所述酶组合物显示对膳食纤维无水解活性;以及b)使酶组合物与整粒谷物组分反应以提供整粒谷物水解产物形式的麸皮混合物。包含至少一种α淀粉酶的酶组合物还可包含蛋白酶。如WO201276051中所述,淀粉酶诸如Validase HT425L(Valley Research)和蛋白酶诸如Alcalase 2.4L(Novozymes)表现出对β葡聚糖或***木聚糖无水解活性。
根据本发明方法的麸皮混合物可先经受包括使麸皮混合物与糖酶和阿魏酸酯酶接触的酶处理,之后再加热至介于100℃和150℃之间的温度。例如,可通过直接蒸汽喷射将麸皮混合物加热至介于100℃和150℃之间的温度。
根据本发明方法的麸皮混合物可在经受包括使麸皮混合物与糖酶和阿魏酸酯酶接触的酶处理之后再进行干燥。例如,可通过辊式干燥来干燥麸皮混合物。
根据本发明方法的麸皮可具有小于500μm的粒度分布D90。本发明人发现大于500μm的粒度分布D90导致诸如相分离的加工问题。D90值为分布中90%的颗粒小于的直径。粒度可例如通过激光散射进行测量。
根据本发明的方法,包括使麸皮混合物与糖酶和阿魏酸酯酶接触的酶处理可在介于30℃和50℃之间、例如介于35℃和45℃之间的温度下进行。根据本发明的方法,包括使麸皮混合物与糖酶和阿魏酸酯酶接触的酶处理可进行介于10分钟和4小时之间、例如介于30分钟和3小时之间、又如介于90分钟和150分钟之间的持续时间。应当理解,本发明的方法可作为间歇流程或连续流程进行。当该方法为连续流程时,酶处理的持续时间是麸皮混合物与糖酶和阿魏酸酯酶接触的平均停留时间。
根据本发明方法的糖酶和/或阿魏酸酯酶可包含在发酵液或发酵液的提取物中,其中发酵液中的微生物已产生糖酶和/或阿魏酸酯酶。根据本发明方法的步骤d的酶处理可通过微生物进行。例如,可用产生糖酶和/或阿魏酸酯酶的微生物来发酵麸皮混合物。微生物可选自细菌、酵母和真菌。细菌可例如选自芽孢杆菌属(Bacillus sp.)(例如枯草芽孢杆菌(B.subtilis)、环状芽孢杆菌(B.circulans))、双歧杆菌属(Bifidobacterium sp.)(例如长双歧杆菌(B.longum)、乳酸双歧杆菌(B.lactis))、微球菌属(Micrococcus sp.)和乳杆菌属(Lactobacillus sp.)(例如约氏乳杆菌(L.johnsonii))。酵母可例如为链霉菌属(Streptomyces sp.)(例如绿孢链霉菌(S.Viridisporus)或恰塔努链霉菌(S.Chattanoogensis))。真菌可例如为曲霉属(Aspergillus sp.)(例如黑曲霉(A.niger)、酱油曲菌(A.sojae)、构巢曲霉(A.nidulans)或米曲霉(A.oryzae))。
根据本发明方法的麸皮混合物可在经受酶处理之后再与食物成分混合或组装。例如,在经受酶处理之后,可在进一步加工期间将麸皮混合物与食物成分混合成饮料、乳制品、宠物食品或食品补充剂。
在另一方面,本发明提供一种包含水解小麦麸皮的组合物,该组合物用于治疗或预防代谢疾病或肥胖症,其中该组合物包含介于0.001重量%和0.25重量%之间的阿魏酸,例如介于0.01重量%和0.15重量%之间的阿魏酸,例如介于0.02重量%和0.1重量%之间的阿魏酸,又如介于0.05重量%和0.09重量%之间的阿魏酸。根据本发明的组合物将提供给个体。在实施方案中,个体为哺乳动物,诸如人、猫、狗或马。本发明可提供包含水解小麦麸皮的组合物在制造用于治疗或预防代谢疾病或肥胖症的药物方面的用途,其中该组合物包含介于0.001重量%和0.25重量%之间的阿魏酸。
在另一方面,本发明提供一种包含水解小麦麸皮的组合物,该组合物用于治疗或预防代谢疾病或肥胖症,其中施用该组合物以提供介于0.3至3.0mg/kg体重/天之间的阿魏酸,例如介于0.4和2.0mg/kg体重/天之间的阿魏酸,又如介于0.6和1.0mg/kg体重/天之间的阿魏酸的剂量。在这样的剂量下,阿魏酸是尤其有利的。优选地,组合物中的所有阿魏酸均作为水解麸皮例如水解小麦麸皮提供。根据本发明方法水解的麸皮包含高水平的游离氨基酸和低分子量可溶性纤维,因此提供良好的营养。本发明可提供包含水解小麦麸皮的组合物在制造用于治疗或预防代谢疾病或肥胖症的药物方面的用途,其中施用组合物以提供介于0.3和3.0mg/kg体重/天之间的阿魏酸的剂量。在另一方面,本发明提供一种通过本发明方法获得(例如可获得)的组合物,该组合物用于治疗或预防代谢疾病或肥胖症。本发明可提供通过本发明方法获得(例如可获得)的组合物在制造用于治疗或预防代谢疾病或肥胖症的药物方面的用途。
在本发明的一个方面,待治疗或预防的代谢疾病可选自糖尿病、高血脂、高血压和心血管疾病。例如,代谢疾病可为II型糖尿病。
根据本发明的组合物可被干燥,例如可被辊式干燥。用于根据本发明的组合物可与赋形剂结合。例如,用于根据本发明的组合物可与赋形剂结合并形成为压制片剂或填充到胶囊中。
用于根据本发明的组合物可形成食物产品的一部分。因此,在一个方面,本发明涉及一种包含根据本发明的组合物的食物产品。在另一方面,本发明涉及一种复合食物产品,其中复合食物产品的至少一部分包含根据本发明的组合物。这可以是其中食物产品由多个独立部分构成的情况(复合物),其中例如只有一个部分包含根据本发明的组合物。
食物产品(根据本发明的组合物可形成食物产品的一部分)可选自饮料、乳制品、谷物产品、宠物食品和食品补充剂。根据本发明的饮料的示例为正餐代用品、口服营养补充剂或补充有水解的整粒谷物的即饮型饮料。根据本发明的乳制品可为粉末状奶制品,例如包含奶粉、阿魏酸以及任选的维生素和矿物质的粉末状奶制品。根据本发明的乳制品可为发酵奶制品诸如酸奶。在本发明的上下文中,术语酸奶可包括但不限于遵守术语“酸奶”相关的本地食品标签法规的材料。根据本发明的谷物产品的示例可选自早餐谷类食品、粥、软食和谷物棒。食物产品可为包含谷物的粉末状奶制品,例如即食粥。根据本发明的宠物食品的示例可选自粗磨食物和球丸。食品补充剂(也称为营养补充剂或膳食补充剂)是旨在补充饮食并提供在人的饮食中可能缺失或可能摄入量不足的营养物质(诸如维生素、矿物质、纤维、脂肪酸或氨基酸)的制剂。根据本发明的食品补充剂形式的示例为胶囊和丸剂。
本发明的组合物可用于体重管理,例如用作饮食补充剂。
本发明的组合物可经由肠道给药施用,优选口服。
本领域的技术人员将理解,他们可自由地组合本文所公开的本发明的所有特征。具体地讲,可将针对本发明方法描述的特征与本发明的组合物组合,反之亦然。另外,可组合针对本发明的不同实施方案所描述的特征。对于具体的特征如果存在已知的等同物,则此类等同物被纳入,如同在本说明书中明确提到这些等同物。根据非限制性实施例,本发明的其他优点和特征将显而易见。
实施例
实施例1:小麦麸皮水解
将小麦麸皮(Provimi Kliba)悬浮于水中,总固体含量为20%至23%。然后在存在0.5%的500BG(Novozymes)的情况下,将悬浮液在65℃下水解一小时。在该过程中取出小麦麸皮样品并进行分析。在先前的试验中,发现65℃是酶变得部分失活之前的最高最佳温度。
通过重复上述过程,但使用直接蒸汽喷射加上加热步骤,检查在水解之前在90℃下预处理10分钟悬浮液的效果。在加热步骤之后,在水解之前冷却悬浮液。图1示出与没有进行预处理(B)的样品相比,热预处理(A)将阿魏酸的释放量增加几乎三倍。酶处理还使低分子量可溶性纤维的含量从3%增加到9%(基于干麸皮)。
Claims (15)
1.制备包含阿魏酸的组合物的方法,所述方法包括以下步骤:
a)形成包含麸皮和水的麸皮混合物,所述混合物具有至少50重量%的水含量并且包含1重量%至50重量%的麸皮;
b)将所述麸皮混合物加热至介于75℃和150℃之间的温度;
c)将所述麸皮混合物冷却至低于50℃;以及
d)使所述麸皮混合物经受酶处理,包括使所述麸皮混合物与糖酶和阿魏酸酯酶接触。
2.根据权利要求1所述的方法,其中通过直接蒸汽喷射在步骤b中加热所述麸皮混合物。
3.根据权利要求2所述的方法,其中所述麸皮混合物通过用α淀粉酶酶促水解整粒谷物来形成,所述α淀粉酶在处于活性状态时表现出对膳食纤维无水解活性。
4.根据权利要求1至3中任一项所述的方法,其中在所述麸皮混合物经受所述酶处理之后将其加热至介于100℃和150℃之间的温度。
5.根据权利要求1至4中任一项所述的方法,其中在所述麸皮混合物经受所述酶处理之后将其进行干燥。
6.根据权利要求1至5中任一项所述的方法,其中所述麸皮具有小于500μm的粒度分布D90。
7.根据权利要求1至6中任一项所述的方法,其中步骤d的所述酶处理在介于30℃和50℃之间的温度下进行。
8.根据权利要求1至7中任一项所述的方法,其中所述麸皮为小麦麸皮。
9.根据权利要求1至8中任一项所述的方法,其中步骤d的所述酶处理通过微生物进行。
10.根据权利要求1至9中任一项所述的方法,其中在所述麸皮混合物经受所述酶处理之后将其与食物成分混合或组装。
11.用于治疗或预防代谢疾病或肥胖症的包含水解小麦麸皮的组合物,其中所述组合物包含介于0.001重量%和0.25重量%之间的阿魏酸。
12.用于治疗或预防代谢疾病或肥胖症的通过根据权利要求1至10中任一项所述的方法获得的组合物。
13.根据权利要求11或权利要求12所述的组合物,其中所述代谢疾病选自II型糖尿病、心血管疾病和肥胖症。
14.用于根据权利要求11至13中任一项所述的组合物,其将口服施用。
15.用于根据权利要求11至14中任一项所述的组合物,其将以介于0.30和3.0mg/kg体重/天之间的阿魏酸的每日剂量施用。
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TWI749435B (zh) * | 2019-09-10 | 2021-12-11 | 大江生醫股份有限公司 | 促進膽固醇代謝相關基因表現之化合物之用途 |
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