CN110468061B - 具有预防或治疗癌症的效果的新型菌株 - Google Patents
具有预防或治疗癌症的效果的新型菌株 Download PDFInfo
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Abstract
Description
Claims (10)
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CN202110013498.5A CN113151036A (zh) | 2018-05-11 | 2019-01-14 | 具有预防或治疗癌症的效果的新型菌株 |
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Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101864347B1 (ko) * | 2017-09-06 | 2018-06-05 | 주식회사 지놈앤컴퍼니 | 락토바실러스 람노수스 lm1019 균주 및 이를 포함하는 비만 또는 당뇨병 예방 및 치료용 조성물 |
CN113151036A (zh) * | 2018-05-11 | 2021-07-23 | 韩国亿诺生物有限公司 | 具有预防或治疗癌症的效果的新型菌株 |
KR102485269B1 (ko) * | 2019-10-18 | 2023-01-06 | 주식회사 지놈앤컴퍼니 | 비피도박테리움 비피덤을 포함하는 면역력 증강 또는 개선용 조성물 |
CN112852682A (zh) * | 2020-08-11 | 2021-05-28 | 刘树林 | 与芽孢杆菌属近缘的厚壁菌门细菌菌株及其抗癌应用 |
KR102291725B1 (ko) * | 2021-04-06 | 2021-08-23 | 주식회사 지놈앤컴퍼니 | 항-cntn4 항체 및 그의 용도 |
KR102391017B1 (ko) * | 2021-07-13 | 2022-04-29 | 한국식품연구원 | 락토코커스 락티스 WiKim0133을 포함하는 암의 예방, 개선 또는 치료용 조성물 |
CN115702908A (zh) * | 2021-08-05 | 2023-02-17 | 香港中文大学 | 用于治疗和预防结肠直肠癌的益生菌组合物 |
KR20230092708A (ko) | 2021-12-16 | 2023-06-26 | 주식회사 엔테로바이옴 | 암 또는 염증성 질환 예방 또는 치료용 약학적 조성물 |
KR102672734B1 (ko) | 2022-01-19 | 2024-06-10 | 록야 주식회사 | 새싹인삼에서 분리한 락토바실러스 람노서스 b3421 및 이를 포함하는 조성물 |
KR20230123429A (ko) | 2022-02-15 | 2023-08-23 | 주식회사 엔테로바이옴 | 암 예방 또는 치료용 약학적 조성물 |
KR102457422B1 (ko) * | 2022-05-04 | 2022-10-21 | 주식회사 메디오젠 | 프로바이오틱스 혼합균주를 유효성분으로 포함하는 대장암의 예방 또는 치료용 조성물 |
CN115011518A (zh) * | 2022-06-13 | 2022-09-06 | 东北农业大学 | 一种具有缓解结肠炎相关结直肠癌作用的乳酸菌混合物及其应用 |
KR102645456B1 (ko) * | 2023-04-24 | 2024-03-13 | 주식회사 메디오젠 | 면역 증진 및 장 건강 증진 활성을 가진 락토코쿠스 락티스 mg5474 균주 및 이를 포함하는 조성물 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012091081A1 (ja) * | 2010-12-28 | 2012-07-05 | キリンホールディングス株式会社 | 乳酸菌を含むインターフェロン産生誘導剤 |
CN107603921A (zh) * | 2017-11-03 | 2018-01-19 | 江南大学(扬州)食品生物技术研究所 | 一种可调节结肠肿瘤信号通路的乳酸乳球菌乳酸亚种及其用途 |
CN107629988A (zh) * | 2017-11-03 | 2018-01-26 | 江南大学(扬州)食品生物技术研究所 | 一种可缓解结直肠癌的两歧双歧杆菌及其用途 |
KR20190129739A (ko) * | 2018-05-11 | 2019-11-20 | 광주과학기술원 | 락토코커스 락티스 gen3033 균주, 및 이를 포함하는 암의 예방 또는 치료용 조성물 |
WO2022231032A1 (ko) * | 2021-04-29 | 2022-11-03 | 주식회사 지놈앤컴퍼니 | 항-cntn4 특이적 항체 및 그의 용도 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3841495B2 (ja) * | 1995-09-14 | 2006-11-01 | サンエイ糖化株式会社 | L−乳酸生産能及びtnf産生誘導活性を有する乳酸菌 |
ID29150A (id) * | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
WO2009049932A1 (en) * | 2007-10-20 | 2009-04-23 | Universite De Liege | Bifidobacterial species |
CN101575582B (zh) * | 2008-05-08 | 2011-10-12 | 景岳生物科技股份有限公司 | 具有抗炎活性的乳杆菌分离株及其用途 |
KR101599769B1 (ko) * | 2012-08-10 | 2016-03-04 | 한국생명공학연구원 | 신규한 락토코쿠스 종 균주 및 이의 용도 |
BR112015018625A2 (pt) * | 2013-02-04 | 2017-09-19 | Seres Therapeutics Inc | composições e métodos |
US20140341853A1 (en) * | 2013-05-14 | 2014-11-20 | Vanna Hovanky | Bacteria-Mediated Therapy for Cancer |
JP2018532814A (ja) * | 2015-11-10 | 2018-11-08 | マッケンナ,エリザベス | 細胞の酸化還元レベルの制御 |
US9999641B2 (en) * | 2016-06-14 | 2018-06-19 | Vedanta Biosciences, Inc. | Treatment of clostridium difficile infection |
KR102205829B1 (ko) * | 2017-06-14 | 2021-01-21 | 기초과학연구원 | 신규한 비피도박테리움 비피덤 균주 및 균주 유래 다당체 |
US20210268041A1 (en) * | 2018-06-22 | 2021-09-02 | Synformulas Gmbh | Non-viable bifidobacterium bifidum bacteria and uses thereof |
CN115261426B (zh) * | 2022-09-26 | 2023-01-03 | 东北农业大学 | 一种具有抗氧化能力的两歧双歧杆菌e3胞外多糖 |
-
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-
2021
- 2021-01-19 JP JP2021006383A patent/JP7119143B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012091081A1 (ja) * | 2010-12-28 | 2012-07-05 | キリンホールディングス株式会社 | 乳酸菌を含むインターフェロン産生誘導剤 |
CN107603921A (zh) * | 2017-11-03 | 2018-01-19 | 江南大学(扬州)食品生物技术研究所 | 一种可调节结肠肿瘤信号通路的乳酸乳球菌乳酸亚种及其用途 |
CN107629988A (zh) * | 2017-11-03 | 2018-01-26 | 江南大学(扬州)食品生物技术研究所 | 一种可缓解结直肠癌的两歧双歧杆菌及其用途 |
KR20190129739A (ko) * | 2018-05-11 | 2019-11-20 | 광주과학기술원 | 락토코커스 락티스 gen3033 균주, 및 이를 포함하는 암의 예방 또는 치료용 조성물 |
WO2022231032A1 (ko) * | 2021-04-29 | 2022-11-03 | 주식회사 지놈앤컴퍼니 | 항-cntn4 특이적 항체 및 그의 용도 |
Non-Patent Citations (6)
Title |
---|
"Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria";Lehouritis 等;《JOURNAL OF CONTROLLED RELEASE》;第222卷;9-17 * |
"Anticancer and anti-inflammatory activity of probiotic Lactococcus lactis NK34";Han 等;《JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY》;第25卷(第10期);1697-1701 * |
"Cancer chemopreventive effects of lactic acid bacteria";Kim 等;《JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY》;第17卷(第8期);1227-1235 * |
"Live Biotherapeutic Lactococcus lactis GEN3013 Enhances Antitumor Efficacy of Cancer Treatment via Modulation of Cancer Progression and Immune System";Kim 等;《CANCERS》;第14卷(第17期);4083 * |
"Role of probiotics in the management of lung cancer and related diseases: An update";Sharma 等;《Journal of Fucntional Food》;第40卷(第22期);625-633 * |
"乳酸乳球菌胞外多糖的制备及对环磷酰胺所致免疫损伤小鼠的保护作用";梅秀明 等;《营养学报》;第31卷(第5期);505-508 * |
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WO2019216649A9 (ko) | 2019-12-05 |
TWI791190B (zh) | 2023-02-01 |
CN110468061A (zh) | 2019-11-19 |
AU2019267042A1 (en) | 2020-12-03 |
JP7119220B2 (ja) | 2022-08-16 |
EP3792343A1 (en) | 2021-03-17 |
AU2019267042B2 (en) | 2022-03-31 |
AU2019267042A8 (en) | 2022-10-06 |
JP2021522866A (ja) | 2021-09-02 |
KR102148223B1 (ko) | 2020-08-27 |
AU2019267042B8 (en) | 2022-10-06 |
AU2020277103B2 (en) | 2022-11-03 |
CA3099906A1 (en) | 2019-11-14 |
CN113151036A (zh) | 2021-07-23 |
WO2019216649A1 (ko) | 2019-11-14 |
JP7119143B2 (ja) | 2022-08-16 |
JP2021129553A (ja) | 2021-09-09 |
AU2020277103A1 (en) | 2020-12-17 |
TWI791111B (zh) | 2023-02-01 |
CA3099906C (en) | 2024-01-16 |
CA3104023A1 (en) | 2019-11-14 |
TW202016291A (zh) | 2020-05-01 |
US20210138003A1 (en) | 2021-05-13 |
TW202118864A (zh) | 2021-05-16 |
US20210322490A1 (en) | 2021-10-21 |
EP3792343A4 (en) | 2022-06-22 |
CA3104023C (en) | 2024-01-30 |
KR20190129739A (ko) | 2019-11-20 |
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