CN110432482A - A kind of infant allergic dermatitis tailored version clinical nutrition formula and preparation method thereof - Google Patents

A kind of infant allergic dermatitis tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN110432482A
CN110432482A CN201910606011.7A CN201910606011A CN110432482A CN 110432482 A CN110432482 A CN 110432482A CN 201910606011 A CN201910606011 A CN 201910606011A CN 110432482 A CN110432482 A CN 110432482A
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vitamin
allergic dermatitis
powder
acid
infant
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尤俊
季敬东
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SHANGHAI OWN-MEDIC HIGH-TECH MEDICAL INDUSTRIAL Co Ltd
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SHANGHAI OWN-MEDIC HIGH-TECH MEDICAL INDUSTRIAL Co Ltd
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    • A—HUMAN NECESSITIES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/17—Amino acids, peptides or proteins
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract

The present invention relates to a kind of infant allergic dermatitis tailored version clinical nutrition formulas comprising: protein, fat, dietary fiber, new resource food, integration of drinking and medicinal herbs ingredient, magnesium gluconate, calcium, iron, zinc, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenic acid, niacin, folic acid, grape seed extract, Kelp Powder.The present invention is based on the nutrition intakes of infant allergic dermatitis patients; by selecting reasonable basal nutrient element; the specific nutrient that there is protection function of intestinal canal and nutrition auxiliary to support for addition simultaneously; to improve infant allergic dermatitis patients trophic structure; there is preferable therapeutic effect for allergic dermatitis and its recurrent is lower; side reaction is smaller, can assist in the treatment of infant allergic dermatitis.

Description

A kind of infant allergic dermatitis tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to special medicine purposes formula food fields, and in particular to a kind of infant allergic dermatitis tailored version faces Bed nutrient formulation and preparation method thereof.
Background technique
Allergy is the immune system of body to the unconformable reaction of foreign substance, in fact to a kind of body not wound at last Evil.Immune system is a kind of highly complex defense mechanism, and group human body can be helped to anti-infective.Immune system can first recognize external Invasion substance, can drive later intracorporal leukocyte cell go attack foreign substance.For certain people, immune system Some innocuous substances can be misdeemed as invader, while leukocyte cell overreact, it can be than invasion to injury caused by body Injury caused by object is more.Therefore, allergic reaction itself forms a kind of disease.
Typical allergic reaction will appear nasal congestion, cough, asthma, itch, is short of breath, having a headache, tired and nettle rash And other fash.The substance that can be caused allergic reaction is known as anaphylactogen.Substantially any substance can cause certain in the world The allergic reaction of certain people in place.
The disease incidence of infant allergic disease such as asthma, allergic rhinitis, eczema, allergic dermatitis etc. has year by year in recent years The trend increased becomes one of the principal disease for endangering children's health.20 kinds of common children's anaphylactogens are peanut, roach Dung beetle, crab, marine fish combination, fresh-water fishes combination, egg white, trees, selects mould, argy wormwood, cat, milk, shrimp, dog, room at acarid combination Dirt, soybean, beef, mutton, common ragweed, hops.The infant that slight allergic dermatitis occurs is likely to occur contrafluxion, scabies Itch, edge can find the light blood cake removed；Water scar, big can then occur on the basis of erythema for severe allergic dermatitis infant Scar, papule, exudation, erosion etc., infant will appear after itch is hard to bear and feeling of pain, but above-mentioned symptom occur in children, due to expression Unclear or parent does not pay attention to and infant is caused excessively to scratch allergy position, causes to infect.Allergic dermatitis disease occurs for children It is related with infant itself constitution, it is also closely related with extraneous factor.
Currently used for treating the measure of infant allergic dermatitis mainly based on Chinese materia medica preparation, ointment, bath foam, such as in State patent CN105521117A discloses a kind of prescription of water extraction object treatment allergic dermatitis using component pericarpium zanthoxyli；Chinese patent CN108686040A discloses a kind of dermatitis ointment, which includes following raw material: realgar, the root of Dahurain angelica, litharge, Chinese gall, soil Chaste tree skin, borneol, camellia oil, dried peppermint leaf, vaseline；Chinese patent CN107854396A provide it is a kind of prevent dermatitis body lotion, It is prepared from the following raw materials in parts by weight: 5-8 parts of Flos Lonicerae extractive solution, 4-6 parts of PORIA ALBA extracting solution, the bletilla striata-red sage root extract 3-9 Part, 0.5-1.8 parts of stearine, 0.8-1.5 parts of Butyrospermum parkii fruit oil, 4-7.5 parts of olive oil, 0.1-0.4 parts of carbomer, 20-40 parts of water.But above-mentioned each patent does not consider to be adjusted improvement from the dietary structure of body, at present also without it is any about The report of the enteral nutrition preparation product of infant allergic dermatitis.
Summary of the invention
The purpose of the present invention is to overcome the defects in the prior art, not for infant allergic dermatitis patients dietary structure Rationally, the bad statuses such as nutrition is uneven, mainly by Diet Adjustment, reasonably combined carbohydrate, protein, fat Energy ratio is supplied, multivitamin, minerals, integration of drinking and medicinal herbs and new resource food, Lai Gaishan class infant allergic skin are selected Scorching patient's trophic structure, auxiliary improve the body health situation of infant allergic dermatitis patients.
To achieve the above object, the present invention adopts the following technical scheme:
The first purpose of the invention is to provide a kind of infant allergic dermatitis tailored version clinical nutrition formulas comprising such as Lower component and its parts by weight: including following component and its parts by weight: 23~35 parts of protein, fatty 28~37 parts, diet 18~23 parts of fiber, 3~6 parts of new resource food, 2~15 parts of integration of drinking and medicinal herbs ingredient, 4~7 parts of magnesium gluconate, calcium 0.4~0.6 Part, 0.015~0.02 part of iron, 0.010~0.015 part of zinc, 0.001~0.0015 part of vitamin A, vitamin D30.0004~ 0.0008 part, 0.01~0.03 part of vitamin E, vitamin B10.001~0.005 part, vitamin B20.001~0.004 part, Vitamin B60.001~0.004 part, vitamin B120.000002~0.000008 part, 0.1~0.3 part of vitamin C, pantothenic acid 0.003~0.007 part, 0.01~0.02 part of niacin, 0.01~0.04 part of folic acid, 0.01~0.5 part of grape seed extract, kelp 0.5~2 part of powder.
In order to advanced optimize above-mentioned clinical nutrition formula, technical measures adopted by the present invention further include:
Further, the protein is selected from hydrolyzing lactoalbumin powder, concentrated whey protein powder, soybean protein isolate, complete Powdered egg, bovine colostrum, whole milk powder, ovalbumin peptide, soybean peptide, ocean fish oligopeptide, wheat oligopeptide, corn oligopeptide powder, At least one of alpha lactalbumin powder, Isin glue collagen Gly-His-Lys, amino acid.More preferably: hydrolyzing lactoalbumin powder and fish glue Former protein peptide powder.The preferred high-quality protein of above-mentioned protein, the present invention is by supplementing appropriate high biological value good protein, comprehensively 8 kinds for balancedly supplementing needed by human body must amino acid.
Further, the amino acid be selected from L-Glutamine, glycine, lysine, serine, arginine, alanine, Methionine, tryptophan, leucine, isoleucine, valine, histidine, tyrosine, phenylalanine, citrulling, ornithine, day At least one of aspartic acid, threonine, glutamic acid, cystine.Amino acid is the basic unit of constitutive protein matter, according to human body Aggregate velocity and synthesis capability, being divided into essential amino acid, nonessential amino acid and condition must amino acid.Glutamine synthesis One of matrix of DNA is played an important role in synthetic proteins matter, is the amino that unique one kind can directly pass through cerebrovascular barrier Acid has the function of strengthen immunity for the leading substance of the immunocyte quickly divided.Glycine has prevention and treatment tissue damage, Oxidation resistance is improved, immunity of organisms is improved, promotes protein synthesis, treats diabetes, the ischemia-reperfusion of metabolic disorder Damage, the effect of cancer and various inflammatory diseases.Lysine improve food protein absorption and utilization, reach it is balanced nutritious, Promote growth, improve memory, body is helped to generate antibody, hormone and enzyme, improves immunity of organisms, increases hemochrome, prevention The effects of cardiovascular and cerebrovascular disease, the growth for promoting bone and cartilaginous tissue, treatment osteoporosis.Serine is in fat and fatty acid It plays a role in metabolism and the growth of muscle, and facilitates the generation of immunoglobulin and antibody, therefore serine exists The important role of performer in terms of immune system.Arginine is mainly sent out by NO approach and adjusting organism endocrine hormone Immunoregulation effect is waved, promotes immunoglobulin to generate, plays an important role in terms of immunity of organism, Intestinal mucosa function. Alanine is mainly the synthesis for participating in histone, deamination generates pyruvic acid and glutamic acid, decarboxylation generate pyruvic acid.In disease Reaction of the energy to immune system relative to disease is very important in sick development process, therefore body tissue is big from blood Amount absorbs alanine to promote glycometabolism be that body energizes, and reinforces autoimmunity with this.Methionine facilitates various in human body Sulfur-containing compound metabolism and the methyl contained by it methylated to Toxic or drug and play the role of removing toxic substances.Group ammonia Acid reduces gastric acidity, mitigates the pain of gastrointestinal procedures, mitigates gestational period vomiting and scorching hot sense, inhibits tight by vegetative nerve Alimentary canal caused by festers, also powerful to anaphylactia, such as asthma；Tryptophan can prevent pellagra, depression Disease improves sleep and adjusts mood.Three kinds of common amino acids in protein, i.e. leucine, isoleucine and valine are united Claim branched-chain amino acid.This amino acid promotes body anabolism by release insulin and growth hormone, and in addition there are anti- The effect of fatigue.Leucine can repair muscle, control blood glucose, and provide energy to bodily tissue, it is necessary to amino acid phenylpropyl alcohol ammonia Acid can inhibit cancer growth, and can reduce the toxic side effect of drug.
Further, the integration of drinking and medicinal herbs ingredient is selected from Radix Glycyrrhizae, Poria cocos, peach kernel, sophora flower, rhizoma imperatae, semen coicis, dent At least one of amaranth, lily, honeysuckle, cordate houttuynia, cape jasmine, dandelion, purple perilla seed, hawthorn, Chinese yam；More preferably: Pu Gong Ying Fen, hawthorn powder, yam flour；Further, the Chinese medicine of integration of drinking and medicinal herbs is by processing, being ground into 100-200 targeted fine powder. Allergic dermatitis category traditional Chinese medicine " wet sore ", " dip dyeing sore " scope, mostly because of spleen insufficiency, damp evil hinders mechanism of qi or wind formation from blood deficiency raw Dry, skin mistake causes QI-blood circulation not normal in moistening inflammation, damp and hot to accumulate caused by resistance.Above-mentioned integration of drinking and medicinal herbs ingredient is with nourishing the blood to expel wind, heat-clearing Based on dampness removing, invigorating the spleen to dry, so as to improve the symptom of infant allergic dermatitis.Radix Glycyrrhizae: sweet and neutral, return heart, lung, spleen, stomach meridian, tool It invigorates the spleen and benefits qi, it is clearing heat and detoxicating, the effect of expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Poria cocos: it is sweet, light, flat, return heart, lung, Spleen, kidney channel have the effect of clearing damp and promoting diuresis, invigorating the spleen, calming heart.Peach kernel: there is promoting blood circulation to dispel for bitter, sweet, flat, return heart, liver, large intestine channel The stasis of blood, relax bowel and defecation, relieving cough and asthma effect.Sophora flower: it is bitter, slightly cold, return liver, large intestine channel, there is cooling blood and hemostasis, the function of clearing liver-fire Effect.Rhizoma imperatae: sweet, cold, return lung, stomach, bladder meridian have the effect of cooling blood and hemostasis, reducing fever and causing diuresis.Semen coicis: it is sweet, light, cool, return Spleen, stomach, lung channel have the effect of clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, detoxicating and resolving a mass.Purslane: acid, tremble with fear, return liver, Large intestine channel has the effect of clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery.Lily: it is sweet, it trembles with fear, distributed in heart and lung channels have Yin nourishing and lung moistening, clearly The effect of heart and tranquilizing mind.Honeysuckle: it is sweet, it trembles with fear, return lung, the heart, stomach meridian have the effect of clearing heat and detoxicating, dispelling wind and heat from the body.Cordate houttuynia: it is pungent, It is slightly cold, it is distributed in lung channel, there is the effect of clearing heat and detoxicating, the carbuncle that disappears toxin expelling, inducing diuresis for treating strangurtia.Cape jasmine: it is bitter, it trembles with fear, return heart, lung, tri-jiao channel, tool There is the effect of purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.Dandelion: it is bitter, it is sweet, it trembles with fear, returns liver, stomach meridian, have clearing heat and detoxicating, disappear The effect of swollen dissipating bind, inducing diuresis for treating strangurtia.Purple perilla seed: it is acrid in flavour and warm in nature, it is distributed in lung channel, there is lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, the function of relax bowel and defecation Effect.Peppermint: pungent, cool, return lung, Liver Channel have the effect of dispelling wind and heat from the body, head clearing, relieving sore-throat, promoting eruption, soothing the liver promoting the circulation of qi.Hawthorn: Sour, sweet, tepor, returns spleen, stomach, Liver Channel, food digesting stomach fortifying, scattered stasis have coronary artery dilator, vasodilator, blood fat-reducing blood pressure-decreasing strong The effect of the heart.Chinese yam: sweet and neutral, returns spleen, lung, kidney channel have the effect of tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission.
Further, the new resource food is selected from DHA algal oil, arachidonic acid oil, gamma-linolenic acid oil, tree peony Seed oil, tea seed oil, samara oil, imperial rice bran oil, conjugated linoleic acid, eucommia ulmoides seed oil, Oligomeric manna sugar, wheat oligopeptide, chitosan, At least one of ginseng (artificial growth), zeaxanthin, hydrolysis yolk powder, the luxuriant Cillium of circle.More preferably: circle bud vehicle Preceding sub- shell powder.Oil substances therein are added in the form of microcapsule powder.Chitosan belongs to high polycation, and active group band is just Bacterial adsorption can be sticked together by charge, prevent its diffusion, after adsorbing bacterium, destroy the cell membrane of bacterium, cause cytoplasm Interior DNA and RNA outflow, to achieve the effect that kill bacterium.The acid that cation can also generate simultaneously with bacterium surface The interaction such as matter such as lipopolysaccharides, techoic acid, teichuronic acid, capsular polysaccharide, forms complicated polyelectrolyte, from And so that the cell membrane function of bacterium is got muddled, is dead.Circle bud isapgol husk is rich in hemicellulose, this fiber cannot be by human body Digestion, can promote growth of probiotics into enteron aisle, to reduce the quantity of harmful bacteria；Circle bud isapgol husk can water swelling 50-100 times, the jellied viscous substance of shape promotes enteron aisle normally to empty；Circle bud isapgol husk contains dietary fiber abundant, And mainly water-soluble dietary fiber not will increase caloric intake.
Further, the fat is selected from olive oil microcapsule powder, tea oil microcapsule powder, fish oil microcapsule powder, two dodecahexaenes At least one of acid lipid, arachidonic acid oil, linseed oil microcapsule powder, more preferably: linseed oil microcapsule powder, fish oil Microcapsule powder；Wherein saturated fatty acid: monounsaturated fatty acids: the weight ratio of polyunsaturated fatty acid is about 1:1:1.Olive oil 79%-83% is reached with (C18:1) content of oleic acid in tea oil.There is anti-inflammatory and immunosuppressive action rich in n-3 fatty acid diets.Fish oil Intake, which increases, can reduce childhood asthma, persistent cough, stridulates and the rapid symptom of night respiration.One having in the progress of female pregnancy period The randomized control study discovery of n-3 polyunsaturated fatty acid is closed, mother's pregnancy period, which supplements polyunsaturated fatty acid, can reduce antigen spy The product of the specific cell factor, and skin skin prick test positive rate and serious allergic rhinitis when can reduce baby 1 years old Generation.Another research discovery mother's pregnancy period, which increases n-3 fatty acid and limits the intake of n-6 fatty acid, makes 18 months childs' Wheezing symptoms mitigate, and when can substantially reduce children 3 years old allergic cough generation.
Further, the dietary fiber be selected from inulin, polydextrose, galactooligosaccharide, oligofructose, xylo-oligosaccharide, At least one of grain dietary fibers such as oligoisomaltose, resistant dextrin, soybean fiber；More preferably: oligofructose.Meals Food fiber can influence gastrointestinal function and influence allergic dermatitis indirectly.
Further, the nutrient formulation further includes 1~5 part of probiotics, and the probiotics is selected from Bifidobacterium, newborn bar Pseudomonas, streptococcus, lactobacillus acidophilus NCFM, animal bifidobacteria Bb-12, bifidobacterium lactis HN019, bifidobacterium lactis Bi- 07, Lactobacillus rhamnosus LGG, Lactobacillus rhamnosus HN001, lactobacillus fermenti CECT5716, in bifidobacterium breve M-16V extremely Few one kind.Previous research thinks that the interaction between heredity, environmental factor decides the performance and development of anaphylactia.At present Studies have shown that the generation of infant allergic disease forms that initialization procedure is related with immune, the variation of intestinal microflora is to mistake The occurrence and development of quick property disease also play an important role.Because probiotics can be colonized in enteron aisle and form biological protection barrier, resist The intrusion of pathogenic microorganisms and anaphylaxis antigenic substance, makes children from enteric infection and anaphylactia.Probiotics has been at present It is widely used in clinical prevention and treats a variety of diseases, especially in child infectious diarrhea, antibiotic-associated diarrhea, inflammatory bowel Significant curative effect is achieved in the treatments of diseases such as disease, functional consitipation, indigestion and newborn's yellow subcutaneous ulcer.
Further, the nutrient formulation further includes 0.003~0.05 part of selenium, and the selenium derives from sodium selenite, selenium-rich At least one of powder of edible fungus, Se-enriched yeast.
Further, vitamin A derives from least one of retinol acetate, retinyl palmitate, beta carotene.
Further, vitamin C sources are at least one of L-AA, L-AA sodium.
Further, source of vitamin E is in d- alpha-tocopherol, dl- alpha-tocopherol, d- α-D-α-tocopherol acetate, dl- α-acetic acid At least one of tocopherol, d- α-tocopheryl succinate, dl- α-tocopheryl succinate.Vitamin E can promote n-3 fatty acid Effect prolong some researches show that interleukins (IL) -6, IL-10, IL-12 and tumor necrosis factor (TNF)-alpha levels are adjusted The generation of slow rat model autoimmune disease.
Further, vitamin D derives from least one of Vitamin D3, ergocalciferol.
Further, vitamin B1From at least one of thiamine hydrochloride, Thiamin mononitrate.
Further, vitamin B2From at least one of riboflavin.
Further, vitamin B6From at least one of puridoxine hydrochloride, pyridoxime 5'-phosphate.
Further, vitamin B12From at least one of cyanocobalamin, hydrochloric acid cyanocobalamin.
Further, zinc is from zinc sulfate, zinc gluconate, zinc oxide, zinc lactate, at least one in zinc citrate Kind.
Further, iron is sub- from ferrous gluconate, ferrous citrate, ironic citrate, ferrous fumarate, lactic acid At least one of iron, ferric pyrophosphate.
Further, calcium source in calcium carbonate, calcium gluconate, calcium citrate, calcium lactate, L-calcium lactate, calcium monohydrogen phosphate, At least one of calcium phosphate.
Further, the infant allergic dermatitis tailored version clinical nutrition formula includes linseed oil microcapsule powder, hydrolysis PURE WHEY, oligofructose, Isin glue collagen Gly-His-Lys, fish oil microcapsule powder, magnesium gluconate, circle luxuriant Cillium, Pu Gong Ying Fen, hawthorn powder, yam flour, Kelp Powder, calcium, iron, zinc, vitamin A, vitamin D3, vitamin E, vitamin B1, vitamin B2、 Vitamin B6, vitamin B12, vitamin C, pantothenic acid, niacin, folic acid, grape seed extract.The nutrient formulation further include: smart ammonia Acid, glutamine, Radix Glycyrrhizae, Poria cocos, peach kernel, sophora flower, rhizoma imperatae, semen coicis, purslane, lily, honeysuckle, cordate houttuynia, cape jasmine, Purple perilla seed, chitosan, lactobacillus acidophilus NCFM, bifidobacterium lactis HN019, selenium.
In above-mentioned nutrient formulation, minerals are important nutrients necessary to human body, and many minerals are immune systems Important composition ingredient, and certain minerals also have different degrees of influence to atopic diseases such as asthma.
Selenium is the confactor of antioxidant catalyzing enzyme.It can be reduced hydroperoxides and other organic peroxides.Cause This plays critical effect in protecting cells from oxidative damage.In adult's research, asthmatic patient serum and diet are taken the photograph The selenium level entered is lower than control group.Also some researches show that asthmatic patient Serum selenium levels and activity of glutathione peroxidase It is lower.In addition, the discovery selenium intake such as Shaheen can reduce Adults Asthma；And it (is especially smoking in most researchs in relation to selenium Crowd) in, it can also obtain High level of selenium conclusion relevant to preferable lung function.
Magnesium passes through relaxation bronchial smooth muscle and plays an important role in terms for the treatment of and preventing asthma.In child study The effect that children apply bronchodilators can be improved in middle discovery, magnesium supplement.
Zinc is necessary to many components of immune system, including phagocyte and Natural killer activity, cellular immunity And humoral immunity.Zinc has convergence antibacterial, and the mucous membrane surface of a wound can be made to form film, has protective effect.There are also studies have shown thats persistently to mend Immune response can be repaired by filling zinc about 1-2 months of physiological dose, and can reduce the generation of infection event.Soutar etc. is mentioned The too low risk that can make one to suffer from atopic diseases, the reaction of bronchus height and allergy symptoms of zinc intake increases in diet out. In addition, lung tissue by different Antioxidation Mechanisms protect itself from damage, and zinc can then be played the part of by certain mechanism it is anti- The role of oxidant.
Vitamin D is unified selective modulator of siberian crabapple, it can be because of exposure duration not to the effect of immunocyte It is same and different.1,25(OH)2D3It is the active metabolite of internal vitamin D, research confirms 1,25 (OH) both at home and abroad2D3 In addition to adjusting internal alcium and phosphor metabolization, also there is extensive effect to immune system.
Vitamin E can increase the resistance to infection.To normal immunocompetence is maintained, especially to T lymphocyte Function is critically important.
In breast-fed babies, the vitamin C of higher concentration and atopic dermatitis at its baby 12 months in breast milk It is related with antigen anaphylactia onset risk reduction.
Grape seed extract is a kind of polyphenols extracted from grape seeds, and polyphenol content is wrapped 95% or more Containing free phenol and polymerized polyphenolic, free phenol is mainly that catechin, epicatechin, gallic acid and catechin, epicatechin do not have Infanticide acid esters, polymerized polyphenolic are keyed the procyanidine of the different polymerization degree formed by free phenol by C4~C6 or C4~C8, The degree of polymerization is lower, and inoxidizability is stronger.Grape seed extract has anti-oxidant, free radical capture, metal ion-chelant, protein In conjunction with etc. bioactivity, wherein bioactivity most outstanding is inoxidizability.Grape seed extract antioxidation mechanism is at least There are three types of: a. carries out dehydrogenation reaction by phenolic hydroxyl group and free radical and generates stable Semiquinone Radicals, to interrupt chain reaction； B. electronics is directly given by the effect of grape seed extract reducing power and removes free radical；C. the gold of chelating starting lipid peroxidation Belong to ion, to cut off the chain reaction of free radical, plays antioxidation.Grape seed extract is cheap, and has good Good antioxidant activity, has no toxic side effect, is the new and effective antioxidant for having development potentiality in natural.
A second object of the present invention is to provide a kind of systems of above-mentioned infant allergic dermatitis tailored version clinical nutrition formula Preparation Method method comprising following steps: weighing each raw material of predetermined amount, wherein vitamin, composite mineral matter, integration of drinking and medicinal herbs at Point, fat and new resource food it is previously prepared at premix；Premix and 2% maltodextrin are first mixed 5~15 minutes；By its Its raw material is mixed according to principle addition incremental step by step, is mixed 10~30 minutes, is discharged, packing.
Further, above-mentioned each raw material is the raw material for the powder type that partial size is 50~200 μm, before configuration and is configured Cheng Houjun passes through sterilization processing.
Further, the dosage form of the nutrient formulation includes nutrient powder, nutrition emulsion, capsule, tablet, pill, takes orally Liquid etc..
Compared with prior art, the invention has the following advantages:
Enteral nutrition preparation of the nutrient formulation of the present invention as infant allergic dermatitis, passes through dietary therapy conduct A kind of ancillary measure of patients in remission.According to the theory of China's Chinese Traditional Medicine, by substantially former by the dietotherapy controlled to demonstrate,prove Then, in conjunction with patient's constitutive character, the Chinese medicine of one or more integration of drinking and medicinal herbs, new resource food, the benefit that can be used for food are used Raw bacterium, amino acid, small peptide class, unsaturated fatty acid, water-soluble dietary fiber, the multivitamin with anti-oxidation function and more Kind minerals are full nutrition or non-whole nutritional formula food, have effects that prevent and alleviate infant allergic dermatitis symptom.
Specific embodiment
The present invention provides a kind of infant allergic dermatitis tailored version clinical nutrition formula, which is characterized in that including such as the following group Point and its parts by weight: 23~35 parts of protein, fat 28~37 parts, 18~23 parts of dietary fiber, 3~6 parts of new resource food, 2~15 parts of integration of drinking and medicinal herbs ingredient, 4~7 parts of magnesium gluconate, 0.4~0.6 part of calcium, 0.015~0.02 part of iron, zinc 0.010~ 0.015 part, 0.001~0.0015 part of vitamin A, vitamin D30.0004~0.0008 part, vitamin E 0.01~0.03 Part, vitamin B10.001~0.005 part, vitamin B20.001~0.004 part, vitamin B60.001~0.004 part, dimension Raw element B120.000002~0.000008 part, 0.1~0.3 part of vitamin C, 0.003~0.007 part of pantothenic acid, niacin 0.01~ 0.02 part, 0.01~0.04 part of folic acid, 0.01~0.5 part of grape seed extract, 0.5~2 part of Kelp Powder.
With reference to embodiment, the specific embodiment of the present invention is further described.Following embodiment is only used for more Add and clearly demonstrate technical solution of the present invention, and not intended to limit the protection scope of the present invention.
Embodiment 1
Infant allergic dermatitis tailored version clinical nutrition formula of the present invention includes following components:
Linseed oil microcapsule powder 24g, hydrolyzing lactoalbumin powder 20g, oligofructose 20g, Isin glue collagen Gly-His-Lys 6g, fish oil The luxuriant Cillium 4g of microcapsule powder 6g, magnesium gluconate 6g, circle, dandelion powder 3g, hawthorn powder 2g, yam flour 2g, Kelp Powder 2g, Calcium 0.5g, iron 0.017g, zinc 0.013g, vitamin A 0.0012g, vitamin D30.0006g, vitamin E 0.02g, dimension life Plain B10.002g, vitamin B20.002g, vitamin B60.002g, vitamin B12It is 0.000004g, vitamin C 0.2g, general Sour 0.005g, niacin 0.015g, folic acid 0.03g, grape seed extract 0.02g.
Preparation method: each component is weighed according to component table, wherein vitamin, minerals, integration of drinking and medicinal herbs, fat and new resources Raw-food material is first prepared into preparation premix according to table；Premix and 2% maltodextrin are first mixed 10 minutes；Then by it Its material puts into mixing machine according to principle incremental step by step, mixes 20 minutes, discharging, weighing record, packing.
Embodiment 2
Infant allergic dermatitis tailored version clinical nutrition formula of the present invention includes following components:
Linseed oil microcapsule powder 29g, hydrolyzing lactoalbumin powder 20g, oligofructose 20g, Isin glue collagen Gly-His-Lys 6g, fish oil The luxuriant Cillium 4g of microcapsule powder 6g, magnesium gluconate 6g, circle, dandelion powder 1g, hawthorn powder 1g, yam flour 1g, Kelp Powder 1g, Calcium 0.5g, iron 0.017g, zinc 0.013g, vitamin A 0.0012g, vitamin D30.0006g, vitamin E 0.02g, dimension life Plain B10.002g, vitamin B20.002g, vitamin B60.002g, vitamin B12It is 0.000004g, vitamin C 0.2g, general Sour 0.005g, niacin 0.015g, folic acid 0.03g, grape seed extract 0.02g.
Preparation method: each component is weighed according to component table, wherein vitamin, minerals, integration of drinking and medicinal herbs, fat and new resources Raw-food material is first prepared into preparation premix according to table；Premix and 2% maltodextrin are first mixed 10 minutes；Then by it Its material puts into mixing machine according to principle incremental step by step, mixes 20 minutes, discharging, weighing record, packing.
Embodiment 3
Infant allergic dermatitis tailored version clinical nutrition formula of the present invention includes following components:
Linseed oil microcapsule powder 29g, hydrolyzing lactoalbumin powder 25g, oligofructose 20g, Isin glue collagen Gly-His-Lys 6g, fish oil The luxuriant Cillium 4g of microcapsule powder 1g, magnesium gluconate 6g, circle, dandelion powder 1g, hawthorn powder 1g, yam flour 1g, Kelp Powder 1g, Calcium 0.5g, iron 0.017g, zinc 0.013g, vitamin A 0.0012g, vitamin D30.0006g, vitamin E 0.02g, dimension life Plain B10.002g, vitamin B20.002g, vitamin B60.002g, vitamin B12It is 0.000004g, vitamin C 0.2g, general Sour 0.005g, niacin 0.015g, folic acid 0.03g, grape seed extract 0.01g.
Preparation method: each component is weighed according to component table, wherein vitamin, minerals, integration of drinking and medicinal herbs, fat and new resources Raw-food material is first prepared into preparation premix according to table；Premix and 2% maltodextrin are first mixed 10 minutes；Then by it Its material puts into mixing machine according to principle incremental step by step, mixes 20 minutes, discharging, weighing record, packing.
Embodiment 4
Infant allergic dermatitis tailored version clinical nutrition formula of the present invention includes following components:
Linseed oil microcapsule powder 22g, hydrolyzing lactoalbumin powder 23g, oligofructose 22g, Isin glue collagen Gly-His-Lys 8g, smart ammonia The luxuriant Cillium 3g of sour 1.5g, glutamine 1.5g, fish oil microcapsule powder 8g, magnesium gluconate 6g, circle, chitosan 3g, Radix Glycyrrhizae Powder 0.2g, Poria cocos powder 0.2g, peach kernel powder 0.2g, sophora flower powder 0.2g, rhizoma imperatae powder 0.2g, coix seed powder 0.2g, purslane powder 0.2g, lily root flour 0.2g, honeysuckle powder 0.2g, herba houttuyniae powder 0.2g, gardenia powder 0.2g, purple perilla seed powder 0.2g, dandelion powder 2g, Hawthorn powder 2g, yam flour 2g, Kelp Powder 2g, calcium 0.5g, iron 0.017g, zinc 0.013g, selenium 0.015g, vitamin A 0.0012g, Vitamin D30.0006g, vitamin E 0.02g, vitamin B10.002g, vitamin B20.002g, vitamin B6 0.002g, vitamin B120.000004g, vitamin C 0.2g, pantothenic acid 0.005g, niacin 0.015g, folic acid 0.03g, grape pip Extract 0.01g, lactobacillus acidophilus NCFM 2g, bifidobacterium lactis HN019 2g.
Preparation method: each component is weighed according to component table, wherein vitamin, minerals, integration of drinking and medicinal herbs, fat and new resources Raw-food material is first prepared into preparation premix according to table；Premix and 2% maltodextrin are first mixed 10 minutes；Then by it Its material puts into mixing machine according to principle incremental step by step, mixes 20 minutes, discharging, weighing record, packing.
Application Example
The present embodiment carries out treatment infant allergic dermatitis clinical experimental study using the nutrient powder of Examples 1 to 4 preparation, It chooses 100 atopic dermatitis patients, and female 22, average age 6 years old, it is non-to have excluded organic disease, wound etc. by male 28 Anaphylaxis case.Stochastic averagina is divided into five groups, respectively control group, example 1 group, 2 groups of embodiment, 3 groups of embodiment and implementation 4 groups of example.Control group gives hydrocortisone ointment, uses by package insert, and 7 days are 1 course for the treatment of.Example 1 group, embodiment 2 groups, 3 groups of embodiment and 4 groups of embodiment give nutrient powder obtained by the embodiment of the present invention 1~4 respectively, dosage be two times a day, 1 100mg.
Criterion of therapeutical effect: invalid-patient symptom absolutely not improves, and has exacerbation sign；Effective-patient symptom, which has, significantly to be changed It is kind, but do not completely disappear yet；Effectively-patient symptom completely disappears.Side reaction: itch, redness, secondary infection, allergic reaction Etc. common side reaction.The experimental results are shown inthe following table:
Experimental group Test number of cases In vain It is effective Effectively Recurrence Side reaction
Control group 20 3 10 7 8 1
Example 1 group 20 2 12 6 4 0
2 groups of embodiment 20 2 9 9 3 0
3 groups of embodiment 20 1 13 6 4 0
4 groups of embodiment 20 1 8 11 2 0
From the foregoing, it will be observed that compared with the control group, nutrient formulation of the present invention for allergic dermatitis therapeutic effect with Hydrocortisone ointment is suitable, even better than hydrocortisone ointment, it was demonstrated that it can effectively prevent and assist in the treatment of anaphylaxis Dermatitis, and its recurrent is lower, side reaction is smaller.This illustrates nutrient formulation prepared by the present invention, can be used as infant allergic skin Scorching daily nutrition equilibrium preparation, and gastral adverse reaction caused by drug therapy can be effectively relieved in it, assist in the treatment of small Youngster's allergic dermatitis.
The present invention is by selecting reasonable basal nutrient element, based on the nutrition intake of infant allergic dermatitis patients, to each The proportion of component is adaptively adjusted, while adding the specific nutrient that there is protection function of intestinal canal and nutrition auxiliary to support, To realize nutrition equilibrium, improves infant allergic dermatitis patients trophic structure, improve its inflammatory reaction and body health situation.
Specific embodiments of the present invention are described in detail above, but it is only used as example, the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, the equivalent modifications and replace that any couple of present invention carries out In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair Change, all should be contained within the scope of the invention.

Claims (10)

1. a kind of infant allergic dermatitis tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight Number: 23~35 parts of protein, fatty 28~37 parts, 18~23 parts of dietary fiber, 3~6 parts of new resource food, integration of drinking and medicinal herbs ingredient 2~15 parts, 4~7 parts of magnesium gluconate, 0.4~0.6 part of calcium, 0.015~0.02 part of iron, 0.010~0.015 part of zinc, vitamin 0.001~0.0015 part of A, vitamin D30.0004~0.0008 part, 0.01~0.03 part of vitamin E, vitamin B1 0.001~0.005 part, vitamin B20.001~0.004 part, vitamin B60.001~0.004 part, vitamin B12 0.000002~0.000008 part, 0.1~0.3 part of vitamin C, 0.003~0.007 part of pantothenic acid, 0.01~0.02 part of niacin, 0.01~0.04 part of folic acid, 0.01~0.5 part of grape seed extract, 0.5~2 part of Kelp Powder.
2. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Protein is selected from hydrolyzing lactoalbumin powder, concentrated whey protein powder, soybean protein isolate, dried whole-egg, bovine colostrum, whole milk Powder, ovalbumin peptide, soybean peptide, ocean fish oligopeptide, wheat oligopeptide, corn oligopeptide powder, alpha lactalbumin powder, collagen egg At least one of white Gly-His-Lys, amino acid.
3. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 2, which is characterized in that described Amino acid be selected from L-Glutamine, glycine, lysine, serine, arginine, alanine, methionine, tryptophan, leucine, Isoleucine, valine, histidine, tyrosine, phenylalanine, citrulling, ornithine, aspartic acid, threonine, glutamic acid, At least one of cystine.
4. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Integration of drinking and medicinal herbs ingredient be selected from Radix Glycyrrhizae, Poria cocos, peach kernel, sophora flower, rhizoma imperatae, semen coicis, purslane, lily, honeysuckle, cordate houttuynia, At least one of cape jasmine, dandelion, purple perilla seed, hawthorn, Chinese yam.
5. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described New resource food be selected from DHA algal oil, arachidonic acid oil, gamma-linolenic acid oil, peony seed oil, tea seed oil, samara oil, Imperial rice bran oil, conjugated linoleic acid, eucommia ulmoides seed oil, Oligomeric manna sugar, wheat oligopeptide, chitosan, ginseng, zeaxanthin, hydrolysis egg At least one of luxuriant Cillium of bloom, circle.
6. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Fat selected from olive oil microcapsule powder, tea oil microcapsule powder, fish oil microcapsule powder, docosahexaenoic acid grease, arachidonic acid oil, At least one of linseed oil microcapsule powder.
7. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Dietary fiber be selected from inulin, polydextrose, galactooligosaccharide, oligofructose, xylo-oligosaccharide, oligoisomaltose, resistant dextrin, At least one of grain dietary fibers such as soybean fiber.
8. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Nutrient formulation further includes 1~5 part of probiotics, and the probiotics is selected from Bifidobacterium, lactobacillus, streptococcus, acidophilus cream Bacillus NCFM, animal bifidobacteria Bb-12, bifidobacterium lactis HN019, bifidobacterium lactis Bi-07, Lactobacillus rhamnosus LGG, mouse At least one of Lee's sugar lactobacillus HN001, lactobacillus fermenti CECT5716, bifidobacterium breve M-16V.
9. a kind of infant allergic dermatitis tailored version clinical nutrition formula according to claim 1, which is characterized in that described Nutrient formulation further includes 0.003~0.05 part of selenium, and the selenium is in sodium selenite, selenium-enriched edible mushroom powder, Se-enriched yeast It is at least one.
10. a kind of preparation of such as infant allergic dermatitis tailored version clinical nutrition formula according to any one of claims 1 to 9 Method, which comprises the steps of: weigh each raw material of predetermined amount, wherein vitamin, composite mineral matter, medicine food are same Derived components, fat and new resource food are previously prepared at premix；Premix and 2% maltodextrin are first mixed 5~15 minutes； Other raw materials are mixed according to principle addition incremental step by step, mixes 10~30 minutes, discharges, packing.
CN201910606011.7A 2019-07-05 2019-07-05 A kind of infant allergic dermatitis tailored version clinical nutrition formula and preparation method thereof Pending CN110432482A (en)

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