CN1104108A - Medicine for treating tuberculosis - Google Patents
Medicine for treating tuberculosis Download PDFInfo
- Publication number
- CN1104108A CN1104108A CN94104024A CN94104024A CN1104108A CN 1104108 A CN1104108 A CN 1104108A CN 94104024 A CN94104024 A CN 94104024A CN 94104024 A CN94104024 A CN 94104024A CN 1104108 A CN1104108 A CN 1104108A
- Authority
- CN
- China
- Prior art keywords
- radix
- fructus
- root
- medicine
- lycii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000008827 tuberculosis Diseases 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title claims description 28
- 229940079593 drug Drugs 0.000 title claims description 9
- 239000006187 pill Substances 0.000 claims abstract description 7
- 238000007796 conventional method Methods 0.000 claims abstract description 3
- 238000011282 treatment Methods 0.000 claims description 23
- 241000756943 Codonopsis Species 0.000 claims description 5
- 241000190633 Cordyceps Species 0.000 claims description 5
- 241000628997 Flos Species 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims 1
- 244000241838 Lycium barbarum Species 0.000 abstract 2
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 2
- 235000015468 Lycium chinense Nutrition 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241001412627 Adenophora liliifolia Species 0.000 abstract 1
- 241000605447 Anemarrhena Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000202726 Bupleurum Species 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 235000002555 Citrus medica var sarcodactylis Nutrition 0.000 abstract 1
- 240000007126 Citrus medica var. sarcodactylis Species 0.000 abstract 1
- 240000006766 Cornus mas Species 0.000 abstract 1
- 241000234435 Lilium Species 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 241001671204 Stemona Species 0.000 abstract 1
- 241000270666 Testudines Species 0.000 abstract 1
- 240000006023 Trichosanthes kirilowii Species 0.000 abstract 1
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 abstract 1
- 229930191283 anemarrhena Natural products 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 235000008113 selfheal Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 238000002649 immunization Methods 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000011254 conventional chemotherapy Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 208000028659 discharge Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an oral pill for treating tuberculosis, which is a honeyed pill prepared from turtle shell, oyster shell, dragon bone, stemona root, baikal skullcap root, root of straight ladybell, dried rehmannia root, anemarrhena rhizome, lily bulb, smoked plum, wolfberry fruit, Chinese angelica root, pilose asiabell root, wolfberry bark, dried orange peel, pulp of dogwood fruit, selfheal spike, aweto, trichosanthes kirilowii maxim, bupleurum root, finger citron, gallnut, nidus vespae, pinellia tuber and safflower by a conventional method.
Description
The present invention relates to a kind of treatment endo-medicine lungy, this is to be the pill that raw material is made with Chinese medicine.The present invention is the follow-up series application of No. 94103367.8 applications.
Tuberculosis is commonly called as " consumptive disease ", is by tuberculosis a kind of chronic infectious disease that germs have invaded the human body causes.Clinical manifestation heating night sweat, inappetence, malaise.Test check can show as the tuberculin test positive.The whole world has 1,700,000,000 populations to infect tuberculosis at present, and 2,000 ten thousand tuberculosis patients are arranged, annual generation 8,000,000, annual dead 3,000,000.From whole world tuberculosis situation, because acquired immune deficiency syndrome (AIDS) is popular, tuberculosis is in rising trend again, and has many drug resistance patients to produce, and difficulty takes place in treatment, and there are 5,000,000 patients in our country at present, and more than 150 ten thousand sources of infection are arranged, and annual dead more than 20 ten thousand.Tuberculosis remains commonly encountered diseases in our country, frequently-occurring disease, serious harm people's health.Up to the present our country can only the registration management patient, and 10%, 90% patient does not have registration and management.Although at present to the existing specific drug of tuberculosis, but in our country, control lungy remains a difficult task, especially also do not have therapy measure for intractable, chronic discharge of bacteria patient, therefore inventing a kind of effective Chinese medicine for the treatment of tuberculosis is the problem that this area presses for research.Particularly invent a kind of instant effect, easy to use, the Chinese patent medicine of determined curative effect is important.
The object of the invention is exactly in order to solve above-mentioned technical barrier, and a kind of Chinese patent medicine for oral administration easy to use, eutherapeutic is provided, and is used for the treatment of tuberculosis.Especially for treatment difficulty tuberculosis.Oral medicine of the present invention and externally applied ointment are used, and effect is better.
Medicine of the present invention is the honeyed pill of making according to a conventional method with the raw material of following prescription: (weight portion)
Carapax Trionycis 10-15 part Concha Ostreae 10-15 part Os Draconis 12-16 part
Radix Stemonae 10-15 part Radix Scutellariae 8-10 part Radix Adenophorae (Radix Glehniae) 12-16 part
Radix Rehmanniae 15-20 part Rhizoma Anemarrhenae 10-15 part Bulbus Lilii 8-12 part
Fructus Mume 5-8 part Fructus Lycii 10-15 part Radix Angelicae Sinensis 8-12 part
Radix Codonopsis 12-16 part Cortex Lycii 10-15 part Pericarpium Citri Reticulatae 15-18 part
Fructus Corni 10-15 part Spica Prunellae 28-35 part Cordyceps 5-10 part
Fructus Trichosanthis 12-16 part Radix Bupleuri 12-16 part Fructus Citri Sarcodactylis 8-12 part
Galla Chinensis 3-5 part Nidus Vespae 8-12 part Rhizoma Pinelliae 8-12 part
Flos Carthami 8-12 part.
The optimum material proportion of medicine of the present invention is (weight portion):
Carapax Trionycis 12g Concha Ostreae 12g Os Draconis 15g
Radix Stemonae 12g Radix Scutellariae 9g Radix Adenophorae (Radix Glehniae) 15g
Radix Rehmanniae 18g Rhizoma Anemarrhenae 12g Bulbus Lilii 10g
Fructus Mume 6g Fructus Lycii 12g Radix Angelicae Sinensis 10g
Radix Codonopsis 15g Cortex Lycii 12g Pericarpium Citri Reticulatae 16g
Fructus Corni 12g Spica Prunellae 30g Cordyceps 6g
Fructus Trichosanthis 15g Radix Bupleuri 15g Fructus Citri Sarcodactylis 10g
Galla Chinensis 3g Nidus Vespae 10g Rhizoma Pinelliae 10g
Flos Carthami 10g.
The medicine for external use of medicine of the present invention and inventor's development uses jointly, has solved a treatment difficult problem intractable lungy that chemotherapy is produced drug resistance, allergy, poison pair effect.The test of pesticide effectiveness shows that medicine of the present invention has stronger inhibitory action to clinical how anti-bacterium or reference culture, and when drug level was higher, then bacteriostasis was stronger.By the culture fluid of medicine inhibition growth, the life or death bacterium staining of smear is checked, mostly is viable bacteria, proves that the present invention has stronger bacteriostasis.
Be the influence of medicine pair cell immunity of the present invention and humoral immunization below:
1, the E-Flos Rosae Rugosae forms experiment:
Two groups of treatment group and matched groups are set up in this group test, and 257 examples are organized in treatment, matched group 260 examples, and oral medicine of the present invention is organized in treatment, to pasting the externally applied ointment of inventor's development; Matched group adopts conventional chemotherapy to merge antibiotic therapy.Do the E-Flos Rosae Rugosae in two groups of cases and form experimenter's 72 examples, wherein 32 examples are organized in treatment, matched group 40 examples, result such as following table
| The example number | Form routine number in the time of two months | Four months shape example numbers | The test case number | Experiment is positive |
| The treatment group | 10 | 24 | 32 | 75％ |
| Matched group | 6 | 11 | 40 | 27.5％ |
Form test by the E-Flos Rosae Rugosae, contrast before and after treatment group and the matched group, the matched group of treatment group as can be seen has notable difference, can judge that thus medicine of the present invention has the effect that improves cellular immune level.
2, humoral immunization is measured
This group is done humoral immunization and is measured 43 examples, divides matched group and treatment group.27 examples are organized in treatment, matched group 16 examples.Treatment group medicine of the present invention for oral administration and externally applied plaster, matched group adopts conventional chemotherapy, and its humoral immunization mensuration situation sees following table for details:
| Immune indexes and normal value (X ± S) | Matched group | The treatment group | ||||
| Before the treatment (X ± S) | The treatment back (X ± S) | The P value | Before the treatment (X ± S) | The treatment back (X ± S) | The P value | |
| LgG13.1 ± 2.66 lgA2.2 ± 0.75 lgM1.5 ± 0.38 complement G ± 0.27 | 20.3±2.7 2.7±1.06 2.2±0.47 1.3±0.21 | 24.5±3.0 2.6±1.04 2.1±0.50 1.3±0.10 | 〉0.05 〉0.05 〉0.05 〉0.05 | 23.8±15.1 2.8±1.07 2.1±0.52 1.2±0.30 | 15.1±2.9 2.6±10.6 1.9±0.04 1.3±0.34 | 〈0.05 〉0.05 〉0.05 〉0.05 |
This group case is exempted from liquid by body fluid and is measured, can see medicine of the present invention to humoral immune function with more obvious to the improvement of I gG.
3, the antibacterial situation report of turning out cloudy after the clinical application:
The patient who observes brought into use medicine of the present invention and externally applied ointment treatment, acid-fast stain June 12 (+), June 15 (+) on June 9th, 1993, June 19 (+), June 24 (+), June 29 (-), July 4 (-), July 11 (-), July 18 (-).Expectoration 3 days blanking times, 3 days, 4 days, 5 days, 5 days, 5 days, 5 days, 7 days, 7 days, 20 days sputum conversions of medication.Rarely seen 2 acid fast bacterias of smear are than obviously reducing (every visual field is all seen average more than 20 before the medication) in the past when looking into expectorant on 12nd after the medication on June 9.Though can see acid fast bacteria several times later on but only be 1-3/full sheet, medicine of the present invention is described to acid-fast bacilli, fine to drug resistance tulase effect.
Embodiment:
Prescription:
Carapax Trionycis 12g Concha Ostreae 12g Os Draconis 15g
Radix Stemonae 12g Radix Scutellariae 9g Radix Adenophorae (Radix Glehniae) 15g
Radix Rehmanniae 18g Rhizoma Anemarrhenae 12g Bulbus Lilii 10g
Fructus Mume 6g Fructus Lycii 12g Radix Angelicae Sinensis 10g
Radix Codonopsis 15g Cortex Lycii 12g Pericarpium Citri Reticulatae 16g
Fructus Corni 12g Spica Prunellae 30g Cordyceps 6g
Fructus Trichosanthis 15g Radix Bupleuri 15g Fructus Citri Sarcodactylis 10g
Galla Chinensis 3g Nidus Vespae 10g Rhizoma Pinelliae 10g
Flos Carthami 10g;
Processing method:
Said medicine is ground into fine powder, makes honeyed pill with the refined honey mixing.
Claims (2)
1, a kind of treatment tuberculosis is characterized in that it is the honeyed pill of being made according to a conventional method by the crude drug of following prescription:
Carapax Trionycis 10-15 part Concha Ostreae 10-15 part Os Draconis 2-16 part
Radix Stemonae 10-15 part Radix Scutellariae 8-10 part Radix Adenophorae (Radix Glehniae) 12-16 part
Radix Rehmanniae 15-20 part Rhizoma Anemarrhenae 10-15 part Bulbus Lilii 8-12 part
Fructus Mume 5-8 part Fructus Lycii 10-15 part Radix Angelicae Sinensis 8-12 part
Radix Codonopsis 12-16 part Cortex Lycii 10-15 part Pericarpium Citri Reticulatae 15-18 part
Fructus Corni 10-15 part Spica Prunellae 28-35 part Cordyceps 5-10 part
Fructus Trichosanthis 12-16 part Radix Bupleuri 12-16 part Fructus Citri Sarcodactylis 8-12 part
Galla Chinensis 3-5 part Nidus Vespae 8-12 part Rhizoma Pinelliae 8-12 part
Flos Carthami 8-12 part, above-mentioned umber is parts by weight.
2, pill according to claim 1 is characterized in that described formula material (parts by weight) proportioning is:
Carapax Trionycis 12g Concha Ostreae 12g Os Draconis 15g
Radix Stemonae 12g Radix Scutellariae 9g Radix Adenophorae (Radix Glehniae) 15g
Radix Rehmanniae 18g Rhizoma Anemarrhenae 12g Bulbus Lilii 10g
Fructus Mume 6g Fructus Lycii 12g Radix Angelicae Sinensis 10g
Radix Codonopsis 15g Cortex Lycii 12g Pericarpium Citri Reticulatae 16g
Fructus Corni 12g Spica Prunellae 30g Cordyceps 6g
Fructus Trichosanthis 15g Radix Bupleuri 15g Fructus Citri Sarcodactylis 10g
Galla Chinensis 3g Nidus Vespae 10g Rhizoma Pinelliae 10g
Flos Carthami 10g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94104024A CN1051234C (en) | 1994-04-15 | 1994-04-15 | Medicine for curing tuberculosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94104024A CN1051234C (en) | 1994-04-15 | 1994-04-15 | Medicine for curing tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1104108A true CN1104108A (en) | 1995-06-28 |
| CN1051234C CN1051234C (en) | 2000-04-12 |
Family
ID=5031386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94104024A Expired - Fee Related CN1051234C (en) | 1994-04-15 | 1994-04-15 | Medicine for curing tuberculosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1051234C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1504763A4 (en) * | 2002-05-14 | 2006-09-06 | Jianzhong Zhu | Traditional chinese pharmaceutical formulation for treatment of paradentosis, process for preparation and use thereof |
| CN1320903C (en) * | 2005-10-21 | 2007-06-13 | 孙宏陶 | Traditional Chinese medicine prepn. for treating tuberculosis |
| CN102413837A (en) * | 2009-04-24 | 2012-04-11 | 国立血清研究所 | A tuberculosis tb vaccine to prevent reactivation |
| CN105025921A (en) * | 2013-03-15 | 2015-11-04 | 宾夕法尼亚大学理事会 | Synthetic immunogens for prophylaxis or treatment of tuberculosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1036329A (en) * | 1988-04-05 | 1989-10-18 | 翟宗国 | The preparation method of Jinfo tuberculous bolus |
| CN1040146A (en) * | 1989-09-16 | 1990-03-07 | 鞍山市结核防治所 | The preparation of tuberculosis plaster thing and Therapeutic Method thereof |
-
1994
- 1994-04-15 CN CN94104024A patent/CN1051234C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1504763A4 (en) * | 2002-05-14 | 2006-09-06 | Jianzhong Zhu | Traditional chinese pharmaceutical formulation for treatment of paradentosis, process for preparation and use thereof |
| CN1320903C (en) * | 2005-10-21 | 2007-06-13 | 孙宏陶 | Traditional Chinese medicine prepn. for treating tuberculosis |
| CN102413837A (en) * | 2009-04-24 | 2012-04-11 | 国立血清研究所 | A tuberculosis tb vaccine to prevent reactivation |
| CN102413837B (en) * | 2009-04-24 | 2015-11-25 | 国立血清研究所 | The tuberculosis TB vaccine of prevention reactivation |
| CN105025921A (en) * | 2013-03-15 | 2015-11-04 | 宾夕法尼亚大学理事会 | Synthetic immunogens for prophylaxis or treatment of tuberculosis |
| CN105025921B (en) * | 2013-03-15 | 2019-02-19 | 宾夕法尼亚大学理事会 | Synthetic immunogen for prevention lungy or treatment |
| US10953079B2 (en) | 2013-03-15 | 2021-03-23 | The Trustees Of The University Of Pennsylvania | Synthetic immunogens for prophylaxis or treatment of tuberculosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1051234C (en) | 2000-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1060392C (en) | Medicine for curing recurrent stomatocace and Behcet's syndrome | |
| CN105168667B (en) | Application of Chinese herbal medicine in delaying bacterial drug resistance | |
| CN1051234C (en) | Medicine for curing tuberculosis | |
| CN1055638C (en) | Selenium-riched Chinese caterpillar fungus oral liquor and its prepn. method | |
| CN116549612A (en) | Antibacterial composition containing plant stem cell factor and preparation method thereof | |
| CN1053363C (en) | Oral liquid of shengxueyin | |
| CN1173371A (en) | Chinese medicine for treating deaf | |
| CN1116068C (en) | Medicine for treating ichthyosis and preparing process thereof | |
| CN1208086C (en) | Reptile phrynosoma tablet for curing pulmonary disease | |
| CN1060051C (en) | Anti-cancer compn. and prepn. thereof | |
| CN1137713C (en) | Chinese medicine oral preparation for curing apoplectic disease-Suyusan and its preparation method | |
| CN1265808C (en) | Combination of medication for anti herpes virus and its application | |
| CN1190229C (en) | Medicine for curing hepatitis B | |
| CN1185005C (en) | Medicine for treating inflammation | |
| CN1056071C (en) | Hepatitis virus inhibitor and prepn. method thereof | |
| CN114146125B (en) | Traditional Chinese medicine composition for inhibiting helicobacter pylori infection in oral cavity | |
| CN1106282A (en) | Medicament for treatment of cancer | |
| CN1706448A (en) | Compound Chinese medicine comprising parasitic loranthus and mistletoe and its use | |
| CN117064986A (en) | Pharmaceutical composition for treating new crown infection and preparation method thereof | |
| CN1176683C (en) | Medicine for treating hepatitis B and other hepatosis | |
| CN107050340B (en) | Traditional Chinese medicine composition for treating necrotizing lymphadenitis and application thereof | |
| CN1049972A (en) | Preparation method of quick-acting capsule for stomach | |
| CN1173352A (en) | Kechuan'an | |
| CN114796044A (en) | A Chinese medicinal compound toothpaste with antibacterial, antiinflammatory and immunity enhancing effects, and its preparation method | |
| CN1579434A (en) | Chaihuang Tonic and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |