CN110403880A - A kind of herb fermenting object and its hand lotion of preparation - Google Patents

Abstract

The present invention relates to a kind of herb fermenting object and its hand lotion of preparation, the herb fermenting object includes: 25-30 parts of Radix Notoginseng, 15-20 parts of camellia leaf, 12-20 parts of Radix Glycyrrhizae, 15-20 parts of pawpaw, 15-20 parts of Radix Salviae Miltiorrhizae, 15-20 parts of safflower, 12-18 parts of Radix Angelicae Sinensis, 20-25 parts of folium artemisiae argyi, 25-30 parts of sea-buckthorn, 10-15 parts of tuniclike psammosilene root, 15-20 parts of aloe, 25-30 parts of lotus leaf, 12-18 parts of mulberry fruit, 10-15 parts of fructus lycii, 12-18 parts of ginkgo leaf, 15-20 parts of Asian puccoon, 15-20 parts of radix scutellariae, 20-25 parts of Cortex Magnoliae Officinalis.Product of the present invention is using natural herbs as basic raw material, it is hand lotion raw material that herb fermenting object, which is prepared, there is no toxic side effect, cooperate other greases, emulsifier that hand lotion is prepared again, the hand lotion energy deep layer moistens, repairs drying, the effect of adjusting hand water and oil balance, nourishing hand skin.

Description

A kind of herb fermenting object and its hand lotion of preparation

Technical field

The present invention relates to detergents and cosmetic technical field of skin care, specifically, being related to a kind of herb fermenting object and its preparation Hand lotion.

Background technique

The skin of people can preferably be protected and be nourished to hand lotion (Hand cream) forming layer protecting film on hand Skin effectively prevent hand coarse dry and cracked, cutin-softening, farthest water lock moisturizing.Although many handguards currently on the market Frost has good moisturizing effect, but there is still a need for further increase for the continuing care for hand, nutritional supplementation and balance. The function of especially some hand lotions is relatively simple, and chemically synthesized component content is high, and long-time service can make cuticula thinning, make At more serious skin disease.Therefore, how to prepare and deploy it is a kind of mild, do not stimulate, skin zero damage and having repaired, is protected The hand lotion for being good for, healing and smoothing the sustainable protections hand function such as skin slight crack is the important of current cosmetic field urgent need to resolve Problem.

Macromolecular in active components of plants cannot provide enough nutrients since molecular weight is higher for hand skin Matter.Therefore, the present invention carries out biological conversion using macromolecular effective component of chinese medicine of the herb fermenting technology to extraction, by plant Macromolecular substances, by microorganism conversion become required new small molecule active ingredient, while to greatest extent retain Original small molecule active ingredient in Chinese medicine, these special small molecule active ingredients in final product can be used as nutrients Matter passes through skin barrier, penetrates into epidermis deep layer, plays the role of maintenance and horn cell is promoted to update, or even can be with Go deep into skin corium, promote fibroblastic growth, promote the generation of collagen, can play and reduce microgroove generation, it is tender Skin promotes the color of skin and the sense that becomes clear, gives the nursing of hand skin deep layer.

A kind of active hand lotion of Chinese herbal medicine ferment is disclosed in Chinese patent CN201710674823.6, the invention is main The preparation of fermentation material is described, but the invention is not mentioned to the collocation of other such as greases required for hand lotion, anti-corrosion Many conventional explanations such as agent, the addition of chelating agent, can not learn whether the hand lotion of invention preparation has in actual use There is superior skin sense.And the present invention provides complete detailed various chemical components and formula rate, it avoids in only focusing on The activity of medicine fermentation material, and the shortcomings that think little of skin sense.

A kind of nutrition moist type hand cream of Chinese patent CN201410658015.7 and preparation method thereof describes a kind of battalion The hand lotion nourished one's nature, wherein also mainly using Chinese herbal medicine as main component, the hand lotion with nourishing effect.But in the patent Grease selection be vegetable oil for example shea butter, wheat-germ oil, rose corn oil impregnate oil, lanatechead saussurea herb with flower corn oil impregnate oil and Forget-me-not oil, tea-seed oil impregnate oil etc..Entire formula is reasonably arranged in pairs or groups without the light grease of use with vegetable oil, because It will not be salubrious, excellent in this skin sense.

A kind of hand lotion containing wild tea oil of Chinese patent CN201510230380.2 describe it is a kind of have coat after feel Profit and it is oiliness, very moist, dosage is few and lasting, it is fast to absorb and it is salubrious it is comfortable, both hands can be enabled soft, smooth cut significantly reduces equal spies The hand lotion of point.But the grease added in formula is wild tea oil, beeswax, only relies only on both greases and other compositions Combination is to be difficult to prepare the salubrious hand lotion of skin sense.In addition to this, the middle active constituent of above-mentioned patent is all with Chinese medicine sheet Based on the intrinsic active constituent of body, mentioned using water, traditional method such as alcohol extracting extracts preparation, these conventional methods are to some Active constituent of macromolecular such as polysaccharide, protein etc. does not utilize adequately, and actual extracting is obtained and can be utilized by skin Active constituent it is seldom, in addition, some chemical components being irritating to the skin in traditional medicine extraction process are not removed, Certain injury can be caused to skin.

Summary of the invention

Against the above deficiency, the present invention provides a kind of herb fermenting object and its hand lotions of preparation by the present invention.The present invention For product using natural herbs as basic raw material, it is hand lotion raw material that herb fermenting object, which is prepared, without toxic side effect, Cooperate other greases, emulsifier that hand lotion is prepared again, which moistens, repairs drying, adjusts hand water oil The effect of balance, nourishing hand skin.

The purpose of the present invention is what is be achieved through the following technical solutions:

The present invention provides a kind of herb fermenting object, each effective component including following parts by weight: 25-30 parts of Radix Notoginseng, 15-20 parts of camellia leaf, 12-20 parts of Radix Glycyrrhizae, 15-20 parts of pawpaw, 15-20 parts of Radix Salviae Miltiorrhizae, 15-20 parts of safflower, 12-18 parts of Radix Angelicae Sinensis, 20-25 parts of folium artemisiae argyi, 25-30 parts of sea-buckthorn, 10-15 parts of tuniclike psammosilene root, 15-20 parts of aloe, 25-30 parts of lotus leaf, 12-18 parts of mulberry fruit, Chinese holly 10-15 parts of matrimony vine, 12-18 parts of ginkgo leaf, 15-20 parts of Asian puccoon, 15-20 parts of radix scutellariae, 20-25 parts of Cortex Magnoliae Officinalis.

The present invention also provides a kind of preparation methods of herb fermenting object, comprising the following steps:

A, each effective component described in claim 1 is weighed in proportion, and weighs wheat bran, dregs of beans；

B, after mixing the weighed each component of step A, deionized water, sugar, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and chlorine is added Change sodium, and is inoculated with S. cervisiae and carries out anaerobic fermentation；

C, high-temperature sterilization is carried out after fermentation, is filtered, gained filtrate is the herb fermenting object.

Preferably, in step A, the additional amount of the wheat bran is the 25% of each effective component total amount, the addition of the dregs of beans Amount is the 15% of each effective component total amount.

Preferably, in step B, the inoculum concentration of the S. cervisiae is 5-8%, the concentration of S. cervisiae is 2 × 10⁶CFU/mL。

Preferably, in step B, the temperature of the anaerobic fermentation is 28-30 DEG C, fermentation time 24-48h.

The present invention also provides a kind of herb fermenting objects to prepare the application in hand lotion.

The present invention also provides a kind of hand lotion, each component including following parts by weight: herb fermenting object 30- above-mentioned 50 parts, 1-3 parts of camellia seed oil, 1-5 parts of half saualane extraction oil of safflower, 1-5 parts of half saualane extraction oil of folium artemisiae argyi, camellia angle 1-5 parts of shark alkane extraction oil, 1-5 parts of Radix Salviae Miltiorrhizae saualane extraction oil, 1-5 parts of Radix Angelicae Sinensis saualane extraction oil, Sucrose Polystearic Acid Esters 1-3 Part, 0.1-1 parts of inulin lauryl carbamate, 1-5 parts of 1,3-BDO, 0.5-3 parts of 1,2- pentanediol, 1,2- hexylene glycol 0.5-3 parts, 0.01-0.5 parts of ceramide II, 0.1-5 parts of hydrolecithin, 0.1-0.5 parts of Retinol Palmitate, modification 0.2-2 parts of tapioca, 0.2-1 parts of parahydroxyacet-ophenone, 0.01-0.05 parts of EDTA- disodium, 0.1-0.5 parts of xanthan gum, go from Sub- water 35-50 parts, 0.01-0.05 parts of essence.

Preferably, the half saualane extraction oil of safflower is prepared by the following method: safflower is suitable after weighing drying Amount, after crushing crusher machine, the sieving of 200 mesh is placed in half saualane, vacuum -0.06MPa item according to the ratio of 0.1-0.5g/ml 24-48h is extracted under part, then in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get；

The half saualane extraction oil of folium artemisiae argyi is prepared by the following method: camellia is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.1-0.5g/ml, extracts 24- under the conditions of vacuum -0.06MPa 48h, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

Preferably, the camellia saualane extraction oil is prepared by the following method: folium artemisiae argyi is appropriate after weighing drying, powder After broken crusher machine, the sieving of 200 mesh is placed in saualane according to the ratio of 0.2-0.7g/ml, extracts under the conditions of vacuum -0.06MPa 24-48h, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

The Radix Salviae Miltiorrhizae saualane extraction oil is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, crushes crusher machine Afterwards, 200 mesh are sieved, and are placed in saualane according to the ratio of 0.2-0.7g/ml, extract 24-48h under the conditions of vacuum -0.06MPa, In 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

The Radix Angelicae Sinensis saualane extraction oil is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, crushes crusher machine Afterwards, 200 mesh are sieved, and are placed in saualane according to the ratio of 0.2-0.7g/ml, extract 24-48h under the conditions of vacuum -0.06MPa, In 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

The present invention also provides a kind of preparation methods of hand lotion, which comprises the following steps:

S1, camellia seed oil, half saualane extraction oil of safflower, half saualane extraction oil of folium artemisiae argyi, camellia are weighed in proportion Saualane extraction oil, Radix Salviae Miltiorrhizae saualane extraction oil, Radix Angelicae Sinensis saualane extraction oil, Sucrose Polystearic Acid Esters, inulin lauryl base amino Formic acid esters, ceramide II, hydrolecithin, Retinol Palmitate are placed in a beaker in holding temperature 75-90 on water-bath DEG C heating water bath melting, as oily phase；

S2, deionized water, herb fermenting object, xanthan gum, parahydroxyacet-ophenone, EDTA- disodium are weighed in proportion be placed in 75- 90 DEG C of heating water baths, stir evenly, until being completely dissolved, obtain water phase；

S3, water phase is poured into oily phase, stirs homogeneous to paste, obtains matrix, then cool down；

S4, modified tapioca starch, 1,3-BDO, 1,2- pentanediol, 1,2- hexylene glycol are weighed in proportion, stir into emulsus Object；

S5, the milk that in the matrix that step S3 is obtained prepared by addition step S4, add essence, homogeneous is to get institute State hand lotion.

Effective component in herb fermenting object of the present invention is as follows:

Radix Notoginseng: for the dry root and rhizome of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen. Compendium of Material Medica: styptic powder blood analgesic therapy, golden sword arrow wound, fall flutter cane sore, blood goes out more than person, chew rotten painting, or mix it for end, blood is Only.Supplementary Amplifications of the Compendium of Materia Medica Radix Notoginseng is the most precious person of Chinese medicine.Radix Notoginseng mainly contains saponin(e, flavones, Argine Monohydrochloride and non-egg Casamino acid, polysaccharide, sterol and inorganic matter, volatile oil and grease isoreactivity ingredient.Radix Notoginseng not only has good hemostasis, work The two-way pharmacological action of blood stagnation resolvation also has apparent blood tonification effect, can promote red blood cell in blood, leucocyte, blood platelet equal part Schizogenesis is long, has the function of anti-aging, removes free radical, can also adjust body metabolism, keep the growth and development of body. It has been reported that notoginsenoside has significant Antiageing effect to exhausted mining areas skin caused by D- galactolipin, can antagonism H2O2 lure The oxidativestress damage for the skin fibroblasts led has protective effect to the human skin fibroblasts of ultraviolet induction.

Camellia leaf: for the leaf of plant of theaceae camellia, it is civil for treat haematemesis, discharging fresh blood stool, dysentery with bloody stool, hemorrhoid hemorrhage, The diseases such as snowslide.Tannin compositions in foreign countries report camellia floral leaf have apparent inhibiting effect to the cutaneum carcinoma and intestinal cancer of animal. Main chemical compositions have containing Quercetin, tsubakisaponin, vitamin C, Theobromine, left-handed epicatechin and dextrorotation cachou extract, mountain Tea tannin A, B, C etc..Studies have shown that camellia flower extract, which has, inhibits the active effect of MMP-1, it is possible to reduce the drop of collagen Solution inhibits light aging, reduces the generation of wrinkle.

Radix Glycyrrhizae: for leguminous plant Glycyrrhiza Uralensis Glycyrrhiza uralensis, swollen fruit Radix Glycyrrhiza The dry root or rhizome of inflata or glycyrrhiza glabra Glycyrrhiza glabra, the main active of Radix Glycyrrhizae are triterpenes Compound (glycyrrhizic acid, enoxolone etc.), flavone compound (licoflavone, licoisoflavanone, glycyrrhizin etc.) and Radix Glycyrrhizae The equal compounds of polysaccharide.Radix Glycyrrhizae and its active constituent can improve the phagocytic function of phagocyte, adjust lymphocyte quantity and function It can, inhibit IgE antibody formation, anti-inflammatory medium and pro-inflammatory cytokines, there is anti-inflammatory, antiallergic action pharmacological activity. Liquorice flavonoids compound (isoliquiritigenin, isoliquiritin, glycyrrhizin, Licochalcone A, glabridin, glycyrol etc.), Radix Glycyrrhizae Polysaccharide and glycyrrhizic acid are the active constituents of its anti-inflammatory anti-allergy inflammation.Licorice and its flavone compound, glycyrrhizic acid There is pharmacological activity Deng to skin diseases such as allergic skin disease, skin neoplasin, virus dermatopathy, pigmentations.Document Report, glycyrrhiza total flavonoid have the function of delay skin aging, and mechanism may be related with the enhancing oxidation resistance of body.It is sweet Careless extract can be relieved the chronic light injury of UV-induced skin, mechanism of action and inhibit the release of inflammatory factor TNF-α and It is apoptosis-related.Licoflavone has protective action to ultraviolet light irradiation mouse skin, and mechanism and enhancing skin histology are anti- Oxidability promotes oxygen radical removing, and skin collagen is promoted to synthesize related

Pawpaw: for the drying and ripening fruit of rosaceous plant chaenomeles lagenaria ChaenomelesSpeciosa (Sweet) Nakai It is real, originate in the genunie medicinal materials of Xuancheng Prefecture, Anhui Province, referred to as Xuancheng's pawpaw.Just have that " pawpaw is everywhere in bright Li Shizhen (1518-1593 A.D.) Compendium of Material Medica Have it, and Xuancheng person is preferred " record.Pawpaw is sour, warm as a kind of conventional Chinese medicine, enters liver, the spleen channel, have calming the liver relaxing muscles and tendons it Effect.Chinese medicine thinks that pawpaw has relaxing muscles and tendons, active, spleen benefiting and stimulating the appetite, Shugan Zhitong, dispelling wind and eliminating dampness value effect, can be used for preventing and controlling Treat rheumatism, cholera, enteritis and vitamin C deficiency etc..Contain proanthocyanidin tannin, sucrose, pawpaw phenol, flavones, soap in pawpaw Glycosides, amino acid, VC, tartaric acid and fumaric acid etc..Pharmacology prove pawpaw in triterpene oleanolic acid have anti-inflammatory it is antibacterial, The effects of reducing transaminase, enhancing body's immunity, the total glycosides of pawpaw is effective portion with anti-inflammatory and antalgic immunoregulation effect , there is apparent inhibiting effect in position to arthritis, foot swelling, moreover it is possible to the caused mouse peritoneal blood capillary of obvious confrontation acetic acid stimulation Pipe permeability increases, and inhibits the granulomatous formation of rat.

Radix Salviae Miltiorrhizae: the drying root and rhizome of Lamiaceae Salvia platymiscium Radix Salviae Miltiorrhizae is one of most common blood-activating and stasis-removing, First recorded in Shennong's Herbal, have effects that stasis-dispelling and pain-killing, nourishing blood and tranquilization.Chemical component in Radix Salviae Miltiorrhizae is broadly divided into fat-soluble Diterpene quinone and water-soluble liposoluble ingredient.Think in the modern medicine study of dermatology, Radix Salviae Miltiorrhizae has improvement Microcirculation, hemorheological property, anticoagulant, immunoregulation effect promote hyperplasia denaturation connective tissue convert, absorb, inhibiting hyperfunction glue Former synthesis, and have the effects that antibacterial, anti-inflammatory, antiandrogen and mild estrogenic activity.

Safflower: for Iridaceae crocus plant also known as west safflower, safron.Safflower is activating microcirculation and removing stasis medicinal from ancient times Good medicine；The pharmacological action of safflower has calmness, eliminating the phlegm, stimulation, solution spasm, for having a stomachache, menstruation regulating, can treat dysentery, morbilli, Urethral infection and diabetes etc..In addition, safflower also has treatment coronary heart disease, inhibits hepatitis virus, the medicines such as strengthen immunity Effect.In recent years, new active constituent such as crocin, Picrocrocin, safranal and crocetin are found in safflower Deng having apparent antitumaous effect, and small toxicity.Crocin it is ultraviolet can to generate resistance by reducing cell activity oxygen cluster The effect of line irradiation, restores skin fibroblasts cell Proliferation and collage synthesis ability, playing the role of anti-light aging has document Report, safflower can be effectively controlled and treat wet environment correlation skin injury, shorten healing time.

Radix Angelicae Sinensis: being nontoxic top grade first recorded in Shennong's Herbal when being classified as the expensive dry root of umbelliferae angelica. Clinically it is mainly used for treating blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, asthenia cold abdominalgia, the diseases such as rheumatic arthralgia.Studies have shown that Volatile oil is the important composition ingredient of Radix Angelicae Sinensis, mainly have Ligustilide, ligustilide, butylidenephthalide, angelicone, in new Radix Angelicae Sinensis Ester, coniferyl alcohol ferulic acid ester, the positive pentanone of adjacent carboxyl benzene, bergapten, fragrant Xing mustard phenol, isoeugenol, vanillic aldehyde, camphoric acid two Methyl esters, the positive pentanone of adjacent carboxyl benzene etc. also contain a variety of chemical components such as phthalide-type and its dimer, phenolic acid class, polysaccharide, flavones.It is existing Prove there is antitumor and prophylactic treatment frostbite for pharmacology.It has been reported that angelica extract has preferable anti-skin Skin aging and whitening double effects can be used as the natural material of whitening and anti-aging cosmetics

Folium artemisiae argyi: for the dried leaf of compositae plant Chinese mugwort Artemisia argyi Levl.et Vant.Begin as formal drug It is loaded in " Mingyi Bielu ", clinic is mainly used in various blood troubles out, controls pruitus outside, has warming channel for arresting bleeding, eliminating cold to stop pain etc. Effect.The main component for having now been found that folium artemisiae argyi folium artemisiae argyi is volatile oil, including 1,8- cineole, borneol, carypohyllene etc..In addition, also Containing chemical components such as terpene, flavones, Phenylpropanoid Glycosides, aromatic acid (aldehyde), steroidal and fatty acid, there is analgesia, anti-inflammatory, hemostasis, resist Bacterium antiviral and antitumor, blood pressure lowering, it is hypoglycemic, relieving asthma, the multiple pharmacological effects such as immunological regulation.It is demonstrate,proved according to modern pharmacology research Real, volatile oil contained in folium artemisiae argyi has promoting blood circulation, detumescence, analgesic, convergence, antipruritic, reduction capillary permeability, antibacterium, resists A variety of effects such as fungi, external application can treat multiple dermatosis.It has been reported that folium artemisiae argyi lotion for treatment pruitus, obtains good Effect.

Sea-buckthorn: for the dry mature fruit of Elaeangnaceae plant sea-buckthorn.Nature and flavor: acid, color, temperature." Chinese Pharmacopoeia " has been included Sea-buckthorn, major function are as follows: cough-relieving apophlegmatic, relieving dyspepsia, promoting blood circulation scattered silt.It is good anti-that modern pharmacology shows that sea-buckthorn has Oxidation effectiveness and radicals scavenging effect, Seabuckthorn Oil have preferable anti-inflammatory effect to zoopery inflammation, draw to croton oil The antiphlogistic effects of the acute inflammation risen are similar to drug hydrocortisone, can obviously inhibit capillary permeability, inhibit exudation, Mitigate swelling, and can increase the phagocytosis of reticuloendothelial system.Seabuckthorn Oil, which also has, promotes regeneration and epithelial tissue to be cured The effect of conjunction.Seabuckthorn Oil has certain adjustment effect to atopic dermatitis patient seabuckthorn oil degree.Life is tieed up in Seabuckthorn Oil Plain A and carotenoid, the latter enter superficial cutaneous capillaries by epidermis and are converted into vitamin A.Vitamin A maintains epithelial tissue Metabolism, prevents epidermal tissue's hyperkeratosis, skin is made to show moist, tender, glossy, smooth good feel.In sea-buckthorn Vitamin E protects fat in skin and fatty acid is not oxidized or seldom oxidation, slows down cutaneous ageing process, while can add Fast microcirculation or peripheral circulation, maintain or promote normal sebum secretion, make skin moisturizing, tender, glossy, smooth.

Tuniclike psammosilene root: for Caryophyllaceae gold genus plant, " the southern regions of the Yunnan Province book on Chinese herbal medicine " records that tuniclike psammosilene root acrid flavour is peppery, the big temperature of property, specially controls face Cold pain.It is civil that trauma hemostasis and traumatic injury, rheumatalgia pain and stomachache are treated with it.The modern pharmacology proves that, it is also possible to it treats Wound, prevention infection.The main composition of tuniclike psammosilene root is pentacyclic triterpene saponin, cyclic peptide, steroid, violet ketone, phenylpropyl alcohol Plain class and alkaloid etc..Pentacyclic triterpene saponin has inhibiting effect to acute and chronic inflammation, to inflammation caused by croton oil The raising of initial stage capillary permeability is inhibited, and maltol glycoside has preferable antioxidation, alkaloids With good antitumor action.

Aloe: being Liliaceae herbaceos perennial.Aloe main component be the anthraquinones such as aloin, mucopolysaccharide, Polypeptide, amino acid (about 20 kinds), organic acid, vitamin, protein and gel component.The ingredient extracted from aloe gel, can For treating pruitus, chloasma, allergic dermatitis, acne, psoriasis, skin ulcer, chapped skin, Fungal Skin The various skin diseases such as inflammation, phlebitis, allergic dermatitis, shingles zoster and radiodermatitis and skin injury, disappear with antibacterial Scorching effect.Human immune system can also significantly be adjusted, it is considered to be a kind of immunomodulator of high effect nontoxic.In cosmetics In, aloe is mainly used for beauty and health care, hair care and hair growth, sun-proof skin care etc..

Lotus leaf: for the leaf of nymphaeaceae plant lotus, Compendium of Material Medica is recorded: " hair tonic vigour, benefit help taste ".With heat-clearing solution The effect of heat, the clear sun of hair tonic, cooling blood and hemostasis.Its main chemical compositions is containing alkaloids, flavones, volatile oil, tannin, tartaric acid, Citric acid, oxalic acid etc..The modern pharmacology proves that lotus leaf has the function of regulating lipid and reducing weight, anti-oxidant anti-ageing, antibacterial.

Mulberry fruit: the ripening fruits of moraceae plants mulberry." Bencao Jingshu " records " mulberry fruit, Gan Hanyi blood is except warm ".Mulberry fruit chemistry Ingredient includes free amino acid, vitamin, microelement, minerals, ethereal oil, alkaloid and flavonoids etc..Modern pharmacology Show that mulberry fruit has enhancing immune function of human body, promotes hematopoietic growth, hypoglycemic, anti-oxidant and anti-aging function Effect.Document report, mulberry all have the function of the effect of significantly anti-oxidant and anti-aging and moistening skin beautifying.

Fructus lycii: for the dry mature fruit of Lycium barbarum L. of solanaceae.Fructus lycii is traditional conventional Chinese medicine simply, begins to carry In Shennong's Herbal, it is classified as top grade.Compendium of Material Medica calls its kidney tonifying, moistening lung, production of sperm, QI invigorating.The chemical component of fructus lycii has Polysaccharides, glycine betaine, carotenoid, vitamin C, amino acid zeaxanthine, two palmitinic acid of zeaxanthine, fructus lycii element A-D etc..Wherein, polysaccharides has promotion immunization, is one of the main active of fructus lycii.Fructus lycii element A, B have inhibition blood The activity of pipe angiotensin converting enzyme.In addition, fructus lycii also has the effects that hypoglycemic, reducing blood lipid, anti-mutagenesis, anti-aging.Study table Bright, fructus lycii has facilitation to collagenous fibres, elastomer and DNA content in dermal tissue, can increase Aged Mice table Skin LC quantity, enhances the effect of skin immune function controlling.Fructus lycii can also by reduce UVB caused by inflammatory factor TNF-α and (or) secretion of IL-1 β is to mitigate skin injury caused by ultraviolet radiation.

Ginkgo leaf: ginkgo is Ginkgoaceae plant (Ginkogo biloba L.), Compendium of Material Medica record its nature and flavor sweetness and bitterness and It is puckery, enter lung, kidney two warp, play the role of relieving asthma and cough.Ginkgo leaf component is complicated, predominantly flavonoids, terpene lactone compound, more Carbohydrate etc..Especially in ginkgo leaf terpene lactone compound (ginkgolides ginkgolides, Bilobalide bilobalide) because The specific receptor antagonist of platelet activating factor (platelet activing factor, PAF), thus especially by Concern.Document report, ginkgo biloba p.e can promote the proliferation and collagen secretion of rat fibroblast, delay skin aging And wrinkle is formed.In addition, it has been reported that ginkgolides can be used for cosmetic treatment skin heart disease and allergy.

Asian puccoon: Boraginaceae herbaceos perennial.Chinese Drug Zicao has long medicinal history in China, sweet in flavor, salty, property It is cold, there are cool blood, activating blood and clearing heat, removing toxic substances and other effects, tcm clinical practice is mainly used for eczema, burn, blood urine and erysipelas etc..In Asian puccoon Effective component have naphthalene Quinone Pigments, benzoquinones, alkaloid, triterpenic acid and acidic polysaccharose etc..Wherein, pigment constituents have Asian puccoon Quinone, Acetylshikonin, alkannan, Asian puccoon are red etc..Studies have shown that Asian puccoon is applied to clinic, there is anti-inflammatory, hemostasis, promote the surface of a wound Healing inhibits epidermal cell hyperplasia, activating microcirculation and removing stasis medicinal, improves local microcirculation, eliminates the effects of local edema, therefore wide It is general to be used to treat skin disease.Further, it is also possible to adjust body's immunity, there are apparent anti-allergic effects.

Radix scutellariae: for the root of Labiatae many years herbaceous plant radix scutellariae (Scutellaria baicalensis Georgi), begin It is listed in Shennong's Herbal, cold in nature, bitter is heat-clearing and damp-drying drug common medicine.Radix scutellariae chemical component has flavonoids, phenolic acid class, benzene second Alcohol, amino acid, sterol, essential oil etc..Baicalin is the main component of radix scutellariae, is radix scutellariae-T- glucuronide, and radix scutellariae has more Kind pharmacological action, main function are anti-oxidant, removing free radical, anti-inflammatory, antitumor, prevention calcium channel, inhibition aldose Reductase, antiviral, antiallergy etc. simultaneously have protective effect to systems such as immune, cardiovascular and cerebrovascular, digestion, nerves, have the heat that disappears dry It is wet, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Baicalein and wogonin can inhibit acute ultraviolet irradiation to cause hairless mouse Damage, improve injury of the ultraviolet irradiation to skin aging, immune system.It has been reported that radix scutellariae has light-protection energy, can subtract Light UVA, UVB can also pass through the table of inhibition transforminggrowthfactor-β1 and III collagen type to the damaging action of Skin Cell Up to level, the abnormal deposition of extracellular matrix is reduced to influence the formation of cicatrix of skin.

Cortex Magnoliae Officinalis: being China's traditional Chinese medicine for Magnoliacea plant Cortex Magnoliae Officinalis.Cortex Magnoliae Officinalis is classified as top grade, property by Shennong's Herbal Temperature, it is bitter, pungent, have the function of eliminating dampness dissolving phlegm, cures mainly in humidity hysteresis wound, phlegm retention cough and asthma.Its chemical component have phenols, alkaloid, Volatile oil, flavones and saponins.Main component has Magnolol and Honokiol.It has been reported that magnolol or derivatives thereof can with Treatment chlosma causes skin disease, and honokiol can treat hyperkeratinization and angling dermatoses, in addition, there are also texts Offering report Cortex Magnoliae Officinalis has effects that whitening.

Herb fermenting object of the invention is directly or indirectly promoted amount of activated in Chinese herbal medicine using the fermentation of microorganism The release of ingredient especially macromolecular compound is decomposed and is recombined, can be with by the new active constituent that fermentation generates It is discharged into Chinese medicine fermented liquid.Chinese medicine fermented liquid after everfermentation passes through compared with the Chinese medical extract without everfermentation Product after fermentation is milder, and active constituent is more stable, and better effect is excellent.Mainly after everfermentation, fermentation Active ingredient of Chinese herbs especially macromolecular compound will form by the degradation and metabolism of microorganism it is some new More stable small-molecule active substance, the active constituent of these obtained small molecules is easier by human body after everfermentation Skin is absorbed and is utilized, and can obtain optimal using effect.

Grease and other compositions in hand lotion of the present invention is as follows:

Half saualane: INCI names C13-16 isoparaffin.A kind of lightweight soothing oil, colourless liquid is almost tasteless, does not wave Hair, density have good spreadability, excellent skin sense, the sliding salubrious sense of silk at 0.761g/mL-0.776g/mL (20 DEG C) Feel, without greasy feeling, not sticky, coefficient of friction is low, can dissolve ultraviolet absorbing agent, will not generate acne.Half squalene can be with The product such as 20 alkane of 12 alkane of isomery, 16 alkane of isomery and isomery etc. of perfect substitution petroleum resources.

Saualane (Squalane): there is silk sliding moist sense of touch, non-greasy, without heavy feeling, soft smooth, spreadability after It is weaker compared with half saualane, it is easy to absorb, quality is soft.Colourless, tasteless, nontoxic, chemical inertness, light and transparent；Moisten and Non-greasy；The moistness and moisture retention of height；Inoxidizability and excellent heat stability；Have within the scope of wide PH steady well It is qualitative；For the hydrocarbon of high-purity；There is good compatibility with the raw material of mineral oil and most of nursing materials；It can add Strong maintenance epidermis, is effectively formed natural protective film, helps the balance between skin and sebum.Saualane is closest to human sebaceous's A kind of lipid, affinity is strong, can combine together with the sebum film of mankind itself, forms one layer of natural screen in skin surface Barrier.Saualane can also inhibit the peroxidating of skin lipid, can effectively infiltrate through skin, and promote the proliferation of skin base cell, To delay skin aging, improving and eliminating chloasma has apparent physiologic effect.Saualane can also be such that skin pore opens, and promote Into blood microcirculation, promote the metabolism of cell, damaged cell is repaired in help.

Half saualane plant extraction oil of the invention extracts plant safflower, the oil in folium artemisiae argyi using half saualane respectively Active constituent similar in the active constituent of dissolubility, especially polarity and half saualane, the crocin in safflower can be half Ingredient dissolves out in squalene, and some volatile compounds of folium artemisiae argyi can dissolve out in half squalene.Obtained safflower half-angle Shark alkane extraction oil, half saualane extraction oil of folium artemisiae argyi contain selective active constituent such as 1,8- cineole, borneol, carypohyllene etc., Effect of plant extraction oil can be helped to be promoted.

Saualane plant extraction oil of the invention extracts plant camellia, Radix Salviae Miltiorrhizae, the oil in Radix Angelicae Sinensis using squalene respectively Active constituent similar in the active constituent of dissolubility, especially polarity and saualane, by the activity in camellia, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis at Divide adequately dissolution, obtained camellia saualane extraction oil, Radix Salviae Miltiorrhizae saualane extraction oil and Radix Angelicae Sinensis saualane extraction oil contain There is active constituent selective required for the present invention, the effect for promoting saualane plant extraction oil can be helped.

Sucrose Polystearic Acid Esters: a kind of nonionic emulsifier of poly- polysaccharide origin, is by the way that hydrophobic chain is grafted onto inulin Poly- polysaccharide skeleton on obtained from plant emulsifier.Its HLB value is 8, water-soluble low insoluble in oil, to the shadow of interfacial tension Sound is small.It has brilliant emulsification, dispersibility.Since dissolubility is lower, Sucrose Polystearic Acid Esters itself will be placed in two-phase it Between interface on, alkyl chain is anchored in oil droplet, and Fructooligosaccharides chain then stays in water phase, forms a barrier to prevent oil droplet weight New polymerization.In emulsification system, even if using extremely low dosage, it is also possible to obtain cost performance is high, sense of touch is soft and smooth and extremely mild Product, be particularly suitable for rich in the formula of oil content, the formula of high electrolyte content, sensitive skin formula.It can also be with it His emulsifier is used in compounding to reduce the dosage of conventional surfactant, can also readily be added and be guaranteed in unstable formula The stability of formula.

Modified tapioca starch:TS starch is a kind of non-transgenic, no aluminium modified tapioca starch.Poly- methyl silicon Sesquioxyalkane is modified to bring velvet-like soft skin sense, can improve the skin sense of various types of cosmetics, can both drop Low greasy feeling, while also can be used as effective substitute of talcum powder.

Inulin lauryl carbamate: INCI name is a kind of sucrose ester emulsifier, is mild nonionic emulsifier, It is soft to skin without ethoxy based component, the moisturizer water supplement function of formula can be improved, promote the suction of hydrophilic active principle It receives, feels all as snug as a bug in a rug after use feeling and use, it can help primary emulsion to participate in emulsification in formula, it can also be in formula Grease is served as to use as skin sense regulator.Texture with mellow and full exquisiteness, excellent coating, velvet-like skin sense, clearly It feels well and feels after smooth painting.It is suitable for sun-proof, care product.It is formed using emulsification physical efficiency prepared by inulin lauryl carbamate Layered liquid crystal structure has long-acting moisture-retaining capacity, can provide and continue moisturizing for 24 hours, while promote the absorption of water-soluble active ingredient, And skin is made to obtain smooth and comfort.

Xanthan gum: also known as xanthan gum, is a kind of biosynthesis glue, is with cornstarch in class is white or pale yellow powder shape It for primary raw material, is fermented under given conditions by microorganism xanthomonas, then through refinement, drying, grinding and manufactured height Molecular polysaccharide polymer.Its molecular structure determines its property: thickening, suspension, salt tolerant, heatproof, acid and alkali-resistance, shearing resistance It cuts.It is that collection is thickened, suspended, emulsifying, being stable at one, the biological carbohydrate gum of superior performance in the world at present.Xanthan gum has good Suspension and emulsibility, it is good it is water-soluble, to heat, to soda acid, to salt, good to the stability of enzymatic hydrolysis.Nineteen eighty-three the United Nations Food and agricultural organization and the World Health Organization (FAO/WHO) official approval xanthan gum are safety food additive, and to its additive amount It is not intended to be limited in any, simultaneously as xanthan gum is a kind of pure natural biosynthesis glue, compared with other chemical synthesis glue more There is the feature of environmental protection.

It is added to a large amount of Chinese medicine fermented liquid and half saualane extraction oil and saualane extraction oil in this hand lotion prescription, leads to The collective effect of the active constituent of everfermentation liquid and half saualane extraction oil and saualane extraction oil is dry, coarse to repair Both hands adjust water and oil balance, the generation that can also inhibit wrinkle, prevent frostbite, pernio and season cracking.It is numerous in this prescription Ingredient has very comprehensive nutrition and anti-oxidant, aging ingredient.Not only there is known active constituent such as in Chinese medicine fermented liquid Notoginsenoside, licoflavone, alkannin etc., also some new active constituents containing the generation after fermentation.Oil components such as mountain Tea-seed oil contains the oleic acid and squalene, vitamin E of high-content；Half saualane extraction oil of safflower, half saualane of folium artemisiae argyi extraction Take oil containing selective active constituent such as 1,8- cineole, borneol, carypohyllene etc.；Camellia saualane extraction oil, Radix Salviae Miltiorrhizae angle Shark alkane extraction oil and Radix Angelicae Sinensis saualane extraction oil are easily absorbed by human skin, can not only prevent season cracking, moreover it is possible to promote table Skin updates, in addition, also having the effect of anti-inflammatory, antiallergic and antiultraviolet.In addition, also added ceramide II, hydrogen in this prescription Change lecithin, both ingredients participate in the metabolism of cuticula as the important ingredient of keratoderma, for protecting skin screen Barrier has very important effect.

Compared with prior art, the present invention have it is following the utility model has the advantages that

1, hand lotion of the invention does not add preservative, using natural traditional Chinese medicine fermentation material as main Effect raw material, does not have Toxic side effect, it is nonirritant, highly-safe；

2, using hand lotion of the present invention, can accelerate that hand chap is promoted to heal, is rapid-action, effect is obvious；It is thick to skin Rough equal skin problems can carry out daily reparation, and sensitive skin crowd is also suitble to use；

3, hand lotion of the invention is easily smeared on the skin, and without greasy feeling, there is good percutaneous permeability, easily quilt Skin absorbs, and improves cell microcirculation, promotes skin metabolism；

4, hand lotion of the invention only needs to smear once for one day, and effect can be reached by not needing secondary smearing more than a day；

5, the raw material overwhelming majority used by hand lotion of the invention is from natural, easy degradation after product use, no It can cause environmental pollution, belong to green product.

Specific embodiment

The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention Protection scope.

Medicinal material, wheat bran, the dregs of beans of following embodiment use are bacterial strain that is commercially available, using in the herb fermenting object preparation For saccharomyces cerevisiae (Saccharomyces cerevisiae Hansen).

Embodiment 1

The preparation of 1.1 herb fermenting objects, includes the following steps:

A) the Chinese medicine composition 1kg for weighing formula ratio (is matched: 30 parts of Radix Notoginseng, camellia leaf 15 by following mass fraction Part, 16 parts of Radix Glycyrrhizae, 20 parts of pawpaw, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of safflower, 16 parts of Radix Angelicae Sinensis, 25 parts of folium artemisiae argyi, 30 parts of sea-buckthorn, tuniclike psammosilene root 15 Part, 20 parts of aloe, 30 parts of lotus leaf, 18 parts of mulberry fruit, 13 parts of fructus lycii, 12 parts of ginkgo leaf, 20 parts of Asian puccoon, 15 parts of radix scutellariae, Cortex Magnoliae Officinalis 25 Part), wheat bran 0.25kg (commercially available), dregs of beans 0.15kg (commercially available) are sieved with 100 mesh sieve after each raw material component pulverizer crushes.

B) each component of step a) is added in the fermentor of 5L, adds the deionized water of 2.5kg, 0.2kg sucrose is another to add Enter potassium dihydrogen phosphate 1.5g, dipotassium hydrogen phosphate 3.0g, sodium chloride 1.5g, is 5% inoculation S. cervisiae, the wine by inoculum concentration The concentration of brewer yeast bacterium is 2 × 10⁶CFU/mL, anaerobic fermentation 24 hours, 28 DEG C of fermentation temperature.

C) 120 DEG C of high-temperature sterilization 20min, 400 mesh filtering, take filtrate to get herb fermenting object；

Half saualane extraction oil of safflower described in 1.2 is prepared by the following method: safflower is appropriate after weighing drying, powder After broken crusher machine, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.5g/ml, extracts under the conditions of vacuum -0.06MPa 48h, then in 55 DEG C of ultrasonic extraction 6h, filtering, take filtrate to get.

Half saualane extraction oil of folium artemisiae argyi described in 1.3 is prepared by the following method: folium artemisiae argyi is appropriate after weighing drying, pulverizer After broken, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.5g/ml, extracts 48h under the conditions of vacuum -0.06MPa, in 50 DEG C of ultrasonic extraction 4h, filtering, take filtrate to get.

Camellia saualane extraction oil described in 1.4 is prepared by the following method: camellia is appropriate after weighing drying, crushes After crusher machine, the sieving of 200 mesh is placed in saualane according to the ratio of 0.5g/ml, extracts 48h under the conditions of vacuum -0.06MPa, in 45 DEG C of ultrasonic extraction 5h, filtering, take filtrate to get.

Radix Salviae Miltiorrhizae saualane extraction oil described in 1.5 is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.5g/ml, 48h is extracted under the conditions of vacuum -0.06MPa, in 55 DEG C ultrasonic extraction 4.5h, filtering, take filtrate to get.

Radix Angelicae Sinensis saualane extraction oil described in 1.6 is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.5g/ml, extracts 48h under the conditions of vacuum -0.06MPa, in 50 DEG C Ultrasonic extraction 4h, filtering, take filtrate to get.

The preparation of 1.7 hand lotions, the specific steps are as follows:

A) 1 part of camellia seed oil, 1 part of half saualane extraction oil of safflower, 1 part of half saualane extraction oil of folium artemisiae argyi, camellia are weighed Flower 1 part of saualane extraction oil, 1 part of Radix Salviae Miltiorrhizae saualane extraction oil, 1 part of Radix Angelicae Sinensis saualane extraction oil, 1 part of Sucrose Polystearic Acid Esters, 0.1 part of inulin lauryl carbamate, 0.01 part of ceramide II, 0.1 part of hydrolecithin, Retinol Palmitate 0.1 part is placed in a beaker in keeping 75 DEG C of heating water bath meltings of temperature on water-bath, as oily phase；

B) 35 parts of deionized water, 30 parts of herb fermenting object, 0.1 part of xanthan gum, 0.2 part of parahydroxyacet-ophenone, EDTA- are weighed 0.01 part of disodium is placed in 75 DEG C of heating water baths, stirs evenly, until being completely dissolved, obtains water phase；

C) to oily mutually melting completely, water phase b) obtained is poured slowly into oily phase, stirring while adding, homogenizer homogeneous 5min, until matrix to be slowly cooled to 45 DEG C to get matrix in uniform milk yellow paste；

D) 0.2 part of modified tapioca starch and 1 part of 1,3-BDO, 0.5 part of 1,2- pentanediol, 1,2- hexylene glycol 0.5 are weighed Part, stir into milk；

E) to the milk for being slowly added d) preparation in c) while stirring, 0.01 part of essence is finally added, homogenizer Homogeneous 5min to get arrive multiple-effect hand lotion.

Embodiment 2

The preparation of 1.1 herb fermenting objects, includes the following steps:

A) the Chinese medicine composition 1kg for weighing formula ratio (is matched: 26 parts of Radix Notoginseng, camellia leaf 18 by following mass fraction Part, 14 parts of Radix Glycyrrhizae, 17 parts of pawpaw, 20 parts of Radix Salviae Miltiorrhizae, 17 parts of safflower, 14 parts of Radix Angelicae Sinensis, 22 parts of folium artemisiae argyi, 25 parts of sea-buckthorn, tuniclike psammosilene root 10 Part, 17 parts of aloe, 25 parts of lotus leaf, 13 parts of mulberry fruit, 12 parts of fructus lycii, 14 parts of ginkgo leaf, 15 parts of Asian puccoon, 18 parts of radix scutellariae, Cortex Magnoliae Officinalis 25 Part), wheat bran 0.25kg (commercially available) is sieved with 100 mesh sieve after dregs of beans 0.15kg (commercially available) pulverizer crushes.

B) it is added in the fermentor of 5L, adds the deionized water of 2.5kg, potassium dihydrogen phosphate is separately added in 0.2kg sucrose 1.5g, dipotassium hydrogen phosphate 3.0g, sodium chloride 1.5g are 5.5% inoculation S. cervisiae by inoculum concentration, the S. cervisiae Concentration is 2 × 10⁶CFU/mL, anaerobic fermentation 48 hours, 30 DEG C of fermentation temperature.

C) 120 DEG C of high-temperature sterilization 20min, 400 mesh filtering, take filtrate to get herb fermenting object；

Half saualane extraction oil of safflower described in 1.2 is prepared by the following method: safflower is appropriate after weighing drying, powder After broken crusher machine, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.4g/ml, extracts under the conditions of vacuum -0.06MPa For 24 hours, then in 40 DEG C of ultrasonic extraction 4.5h, filtering, take filtrate to get.

Half saualane extraction oil of folium artemisiae argyi described in 1.3 is prepared by the following method: folium artemisiae argyi is appropriate after weighing drying, pulverizer After broken, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.35g/ml, extracts under the conditions of vacuum -0.06MPa for 24 hours, In 45 DEG C of ultrasonic extraction 4h, filtering, take filtrate to get.

Camellia saualane extraction oil described in 1.4 is prepared by the following method: camellia is appropriate after weighing drying, crushes After crusher machine, the sieving of 200 mesh is placed in saualane according to the ratio of 0.55g/ml, extracts under the conditions of vacuum -0.06MPa for 24 hours, In 50 DEG C of ultrasonic extraction 6h, filtering, take filtrate to get.

Radix Salviae Miltiorrhizae saualane extraction oil described in 1.5 is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.45g/ml, 28h is extracted under the conditions of vacuum -0.06MPa, in 45 DEG C ultrasonic extraction 4.5h, filtering, take filtrate to get.

Radix Angelicae Sinensis saualane extraction oil described in 1.6 is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.6g/ml, extracts 30h under the conditions of vacuum -0.06MPa, in 45 DEG C Ultrasonic extraction 6h, filtering, take filtrate to get.

The preparation of 1.7 hand lotions, the specific steps are as follows:

A) 3 parts of camellia seed oil, 5 parts of half saualane extraction oil of safflower, 5 parts of half saualane extraction oil of folium artemisiae argyi, camellia are weighed Flower 5 parts of saualane extraction oil, 5 parts of Radix Salviae Miltiorrhizae saualane extraction oil, 5 parts of Radix Angelicae Sinensis saualane extraction oil, 3 parts of Sucrose Polystearic Acid Esters, 1 part of inulin lauryl carbamate, 0.5 part of ceramide II, 5 parts of hydrolecithin, 0.5 part of Retinol Palmitate set In keeping 90 DEG C of heating water bath meltings of temperature on water-bath in beaker, as oily phase；

B) 50 parts of deionized water, 50 parts of herb fermenting object, 0.5 part of xanthan gum, 1 part of parahydroxyacet-ophenone, EDTA- bis- are weighed 0.05 part of sodium is placed in 90 DEG C of heating water baths, stirs evenly, until being completely dissolved, obtains water phase；

C) to oily mutually melting completely, water phase b) obtained is poured slowly into oily phase, stirring while adding, homogenizer homogeneous 10min, until matrix to be slowly cooled to 45 DEG C to get matrix in uniform milk yellow paste；

D) 2 parts of modified tapioca starch and 5 parts of 1,3-BDO, 3 parts of 1,2- pentanediol, 3 parts of 1,2- hexylene glycol, stirring are weighed At milk；

E) to the milk for being slowly added d) preparation in c) while stirring, 0.05 part of essence is finally added, homogenizer Homogeneous 5min to get arrive multiple-effect hand lotion.

Embodiment 3

The preparation of 1.1 herb fermenting objects, includes the following steps:

A) the Chinese medicine composition 1kg for weighing formula ratio (is matched: 25 parts of Radix Notoginseng, camellia leaf 20 by following mass fraction Part, 20 parts of Radix Glycyrrhizae, 15 parts of pawpaw, 15 parts of Radix Salviae Miltiorrhizae, 20 parts of safflower, 18 parts of Radix Angelicae Sinensis, 20 parts of folium artemisiae argyi, 27 parts of sea-buckthorn, tuniclike psammosilene root 12 Part, 20 parts of aloe, 27 parts of lotus leaf, 15 parts of mulberry fruit, 15 parts of fructus lycii, 18 parts of ginkgo leaf, 17 parts of Asian puccoon, 20 parts of radix scutellariae, Cortex Magnoliae Officinalis 20 Part), wheat bran 0.25kg (commercially available) is sieved with 100 mesh sieve after dregs of beans 0.15kg (commercially available) pulverizer crushes.

B) it is added in the fermentor of 5L, adds the deionized water of 2.5kg, potassium dihydrogen phosphate is separately added in 0.2kg sucrose 1.5g, dipotassium hydrogen phosphate 3.0g, sodium chloride 1.5g, by inoculum concentration be 6% inoculation S. cervisiae, the S. cervisiae it is dense Degree is 2 × 10⁶CFU/mL, anaerobic fermentation 36 hours, 28.5 DEG C of fermentation temperature.

C) 120 DEG C of high-temperature sterilization 20min, 400 mesh filtering, take filtrate to get herb fermenting object；

Half saualane extraction oil of safflower described in 1.2 is prepared by the following method: safflower is appropriate after weighing drying, powder After broken crusher machine, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.1g/ml, extracts under the conditions of vacuum -0.06MPa 38h, then in 48.5 DEG C of ultrasonic extraction 5h, filtering, take filtrate to get.

Half saualane extraction oil of folium artemisiae argyi described in 1.3 is prepared by the following method: folium artemisiae argyi is appropriate after weighing drying, pulverizer After broken, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.45g/ml, extracts 40h under the conditions of vacuum -0.06MPa, In 42.5 DEG C of ultrasonic extraction 4.5h, filtering, take filtrate to get.

Camellia saualane extraction oil described in 1.4 is prepared by the following method: camellia is appropriate after weighing drying, crushes After crusher machine, the sieving of 200 mesh is placed in saualane according to the ratio of 0.55g/ml, extracts 32h under the conditions of vacuum -0.06MPa, In 55 DEG C of ultrasonic extraction 4h, filtering, take filtrate to get.

Radix Salviae Miltiorrhizae saualane extraction oil described in 1.5 is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.7g/ml, 41.5h is extracted under the conditions of vacuum -0.06MPa, in 55 DEG C of ultrasonic extraction 5.5h, filtering, take filtrate to get.

Radix Angelicae Sinensis saualane extraction oil described in 1.6 is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.65g/ml, 44h is extracted under the conditions of vacuum -0.06MPa, in 42 DEG C ultrasonic extraction 5.2h, filtering, take filtrate to get.

The preparation of 1.7 hand lotions, the specific steps are as follows:

A) 2 parts of camellia seed oil, 3 parts of half saualane extraction oil of safflower, 3 parts of half saualane extraction oil of folium artemisiae argyi, camellia are weighed Flower 3 parts of saualane extraction oil, 3 parts of Radix Salviae Miltiorrhizae saualane extraction oil, 3 parts of Radix Angelicae Sinensis saualane extraction oil, 2 parts of Sucrose Polystearic Acid Esters, 0.55 part of inulin lauryl carbamate, 0.255 part of ceramide II, 2.55 parts of hydrolecithin, vitamin A palmitinic acid 0.3 part of ester is placed in a beaker in keeping 80 DEG C of heating water bath meltings of temperature on water-bath, as oily phase；

B) weigh 42.5 parts of deionized water, 40 parts of herb fermenting object, 0.3 part of xanthan gum, 0.6 part of parahydroxyacet-ophenone, 0.03 part of EDTA- disodium is placed in 80 DEG C of heating water baths, stirs evenly, until being completely dissolved, obtains water phase；

C) to oily mutually melting completely, water phase b) obtained is poured slowly into oily phase, stirring while adding, homogenizer homogeneous 7.5min, until matrix to be slowly cooled to 45 DEG C to get matrix in uniform milk yellow paste；

D) 1.1 parts of modified tapioca starch and 3 parts of 1,3-BDO, 1.75 parts of 1,2- pentanediol, 1,2- hexylene glycol are weighed 1.75 parts, stir into milk；

E) to the milk for being slowly added d) preparation in c) while stirring, 0.03 part of essence is finally added, homogenizer Homogeneous 5min to get arrive multiple-effect hand lotion.

Embodiment 4

The preparation of 1.1 herb fermenting objects, includes the following steps:

A) the Chinese medicine composition 1kg (mass fraction: 28 parts of Radix Notoginseng, 16 parts of camellia leaf, 17 parts of Radix Glycyrrhizae, wood of formula ratio is weighed 19 parts of melon, 18 parts of Radix Salviae Miltiorrhizae, 18 parts of safflower, 12 parts of Radix Angelicae Sinensis, 21 parts of folium artemisiae argyi, 28 parts of sea-buckthorn, 13 parts of tuniclike psammosilene root, 15 parts of aloe, lotus 28 parts of leaf, 12 parts of mulberry fruit, 10 parts of fructus lycii, 15 parts of ginkgo leaf, 18 parts of Asian puccoon, 17 parts of radix scutellariae, 22 parts of Cortex Magnoliae Officinalis), wheat bran 0.25kg (commercially available) sieves with 100 mesh sieve after dregs of beans 0.15kg (commercially available) pulverizer crushes.

B) it is added in the fermentor of 5L, adds the deionized water of 2.5kg, potassium dihydrogen phosphate is separately added in 0.2kg sucrose 1.5g, dipotassium hydrogen phosphate 3.0g, sodium chloride 1.5g, by inoculum concentration be 8% inoculation S. cervisiae, the S. cervisiae it is dense Degree is 2 × 10⁶CFU/mL, anaerobic fermentation 48 hours, 30 DEG C of fermentation temperature.

C) 120 DEG C of high-temperature sterilization 20min, 400 mesh filtering, take filtrate to get herb fermenting object；

Half saualane extraction oil of safflower described in 1.2 is prepared by the following method: safflower is appropriate after weighing drying, powder After broken crusher machine, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.45g/ml, extracts under the conditions of vacuum -0.06MPa 28.5h, then in 51.5 DEG C of ultrasonic extraction 6h, filtering, take filtrate to get.

Half saualane extraction oil of folium artemisiae argyi described in 1.3 is prepared by the following method: folium artemisiae argyi is appropriate after weighing drying, pulverizer After broken, the sieving of 200 mesh is placed in half saualane according to the ratio of 0.33g/ml, extracts under the conditions of vacuum -0.06MPa for 24 hours, In 40 DEG C of ultrasonic extraction 5.8h, filtering, take filtrate to get.

Camellia saualane extraction oil described in 1.4 is prepared by the following method: camellia is appropriate after weighing drying, crushes After crusher machine, the sieving of 200 mesh is placed in saualane according to the ratio of 0.25g/ml, extracts under the conditions of vacuum -0.06MPa for 24 hours, In 48 DEG C of ultrasonic extraction 4h, filtering, take filtrate to get.

Radix Salviae Miltiorrhizae saualane extraction oil described in 1.5 is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.57g/ml, 35h is extracted under the conditions of vacuum -0.06MPa, in 47 DEG C ultrasonic extraction 4.8h, filtering, take filtrate to get.

Radix Angelicae Sinensis saualane extraction oil described in 1.6 is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, and pulverizer is broken After broken, the sieving of 200 mesh is placed in saualane according to the ratio of 0.45g/ml, extracts 28h under the conditions of vacuum -0.06MPa, in 43.5 DEG C of ultrasonic extraction 4.5h, filtering, take filtrate to get.

The preparation of 1.7 hand lotions, the specific steps are as follows:

A) weigh 1 part of camellia seed oil, 3.5 parts of half saualane extraction oil of safflower, 2.5 parts of half saualane extraction oil of folium artemisiae argyi, 5 parts of camellia saualane extraction oil, 5 parts of Radix Salviae Miltiorrhizae saualane extraction oil, 1 part of Radix Angelicae Sinensis saualane extraction oil, Sucrose Polystearic Acid Esters 1.5 parts, 0.5 part of inulin lauryl carbamate, 0.08 part of ceramide II, 0.5 part of hydrolecithin, vitamin A palm 0.25 part of acid esters is placed in a beaker in keeping 85 DEG C of heating water bath meltings of temperature on water-bath, as oily phase；

B) 35 parts of deionized water, 45 parts of herb fermenting object, 0.4 part of xanthan gum, 0.5 part of parahydroxyacet-ophenone, EDTA- are weighed 0.02 part of disodium is placed in 85 DEG C of heating water baths, stirs evenly, until being completely dissolved, obtains water phase；

C) to oily mutually melting completely, water phase b) obtained is poured slowly into oily phase, stirring while adding, homogenizer homogeneous 8.5min, until matrix to be slowly cooled to 45 DEG C to get matrix in uniform milk yellow paste；

D) 1.5 parts of modified tapioca starch and 1 part of 1,3-BDO, 2.5 parts of 1,2- pentanediol, 1,2- hexylene glycol 2.5 are weighed Part, stir into milk；

E) to the milk for being slowly added d) preparation in c) while stirring, 0.05 part of essence is finally added, homogenizer Homogeneous 5min to get arrive multiple-effect hand lotion.

Comparative example 1

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: without preparing herb fermenting object, Herb fermenting object is substituted with deionized water in step 1.7, remaining is consistent with embodiment 1.

Comparative example 2

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: using azymous Chinese medical extract Instead of herb fermenting object prepared by step 1.1, remaining is consistent with embodiment 1.

The preparation of the azymous Chinese medical extract, includes the following steps:

A) the Chinese medicine composition 1kg for weighing formula ratio (is matched: 30 parts of Radix Notoginseng, camellia leaf 15 by following mass fraction Part, 16 parts of Radix Glycyrrhizae, 20 parts of pawpaw, 20 parts of Radix Salviae Miltiorrhizae, 15 parts of safflower, 16 parts of Radix Angelicae Sinensis, 25 parts of folium artemisiae argyi, 30 parts of sea-buckthorn, tuniclike psammosilene root 15 Part, 20 parts of aloe, 30 parts of lotus leaf, 18 parts of mulberry fruit, 13 parts of fructus lycii, 12 parts of ginkgo leaf, 20 parts of Asian puccoon, 15 parts of radix scutellariae, Cortex Magnoliae Officinalis 25 Part), after pulverizer crushes, sieve with 100 mesh sieve.

B) deionized water for adding 2.5kg is heated to 100 DEG C of high temperature and extracts 8h, and the filtering of 400 mesh takes filtrate to get Chinese medicine Extract.

Comparative example 3

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, the ratio of Radix Glycyrrhizae is 40 parts, remaining is consistent with embodiment 1.

Comparative example 4

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, 2 parts of fructus lycii, remaining is consistent with embodiment 1.

Comparative example 5

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, camellia leaf is not added.

Comparative example 6

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, lotus leaf is not added.

Comparative example 7

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, Asian puccoon is not added.

Comparative example 8

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, in step 1.1 In the preparation of medicine fermentation material, sea-buckthorn is not added.

Comparative example 9

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, the shield of step 1.7 In the preparation of hand frost, herb fermenting object additive amount is 20 parts, and deionized water is 60 parts, remaining is consistent with embodiment 1.

Comparative example 10

The method of this comparative example and embodiment 2 is essentially identical, the difference is that only: in this comparative example, the shield of step 1.7 In the preparation of hand frost, herb fermenting object additive amount is 60 parts, and deionized water is 25 parts, remaining is consistent with embodiment 1.

Comparative example 11

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: in this comparative example, the step 1.2 The specific method is as follows:

Safflower extraction oil described in 1.2 is prepared by the following method: safflower is appropriate after weighing drying, crushes crusher machine Afterwards, 200 mesh are sieved, and are placed in half saualane according to the ratio of 0.01g/ml, 48h are extracted under the conditions of vacuum -0.06MPa, then In 55 DEG C of ultrasonic extraction 6h, filtering, take filtrate to get.

Remaining is consistent with embodiment 1.

Comparative example 12

The method of this comparative example and embodiment 1 is essentially identical, the difference is that only: this comparative example does not use plant extraction Oil, half saualane extraction oil of safflower and half saualane extraction oil of folium artemisiae argyi are directly with the replacement of half saualane, camellia saualane extraction Oil, Radix Salviae Miltiorrhizae saualane extraction oil and Radix Angelicae Sinensis saualane extraction oil is taken directly to replace with saualane, remaining is consistent with embodiment 1.

Comparative example 13

Commercially available Tayoi snake oil anticracking hand lotion has effects that nourishing, anticracking, soft and smooth, moist.Its main sufficiently packet It includes: glycerol, natural wet nurse fruit oil, snake oil essence, cholesterine etc..

Compliance test result:

1. physical and chemical index；

The physical and chemical index of embodiment 1-4 is as follows:

1.1 product characteristics

The product of 1-4 of embodiment of the present invention preparation be it is light yellow, soft, it is fine and smooth uniformly, spreadability it is good, moisturizing, taste Profit, non-greasy.

The test of 1.2pH value

The hand lotion product for taking 1-4 of the embodiment of the present invention to prepare, is measured, pH range is between 6.0-7.0 with pH meter.

1.3 heat-resisting, cold-resistant tests:

The hand lotion product for taking 1-4 of the embodiment of the present invention to prepare is placed in bottle for cosmetics, respectively in 48 DEG C and 40 DEG C of items It is placed in insulating box under part, keeps 48h, observed after restoring room temperature, the abnormal phenomenon such as no layering demulsification.

The hand lotion product for taking 1-4 of the embodiment of the present invention to prepare is placed in bottle for cosmetics, is transferred respectively in -8 DEG C of conditions It is placed in refrigerator, keeps 48h, observed after restoring room temperature, the abnormal phenomenon such as no layering demulsification.

1.4 centrifugation tests:

The embodiment 1-4 hand lotion prepared is placed in tool plug test tube, 4000r/min carries out centrifugation and investigates 30min, nothing Water-oil separating phenomenon occurs.

1.5 study on the stability:

The hand lotion of the preparation of embodiment 1-4 is placed in bottle for cosmetics, in room temperature (20 DEG C), high temperature (40 DEG C) and low (4 DEG C) standings of temperature are investigated 3 months, and no water-oil separating and demulsifying phenomenon, color, smell, Material are without significant change.

2. irritation, scratch test

Small white mouse back cuts off hair, smears hand lotion prepared by embodiment 1-4 and comparative example 2 respectively in cutting plucked portion Position, and do not smear position and be compared, acetonideexample 1-4 finds no irritation and allergic reaction, and prepared by ratio 2 Sample discovery has slight stimulate the reaction.

Respectively the Example 1-4 and sample 1g of comparative example 2 be applied to respectively volunteer (20-60 years old, every group of embodiment 50 People, totally 200 people) the back of the hand, observe after 30min, embodiment 1-4 does not occur the bad phenomenons such as rubescent, dermexanthesis, and comparative example 2 Sample discovery have redness phenomenon.

Product of the invention has good safety as the result is shown, and Product Safety prepared by comparative example 2 is poor.It says The Product Safety of the bright preparation using plant fermented liquid is higher than traditional vegetation water safety.

3. efficacy test of releiving immediately

Method: volunteer 90, healthy population of the age at 20-60 years old is divided into 18 groups, every group of 5 people.

Test position: facial lip nasal fossa.

Smear 10% lactic acid in test section (purchase of Sigma company, 100% deionized water are diluted to 10% solution). When subject perception to stimulation when, smear test sample on one side, do blank control on one side.Test subject is according to feeling of pain, 0min, 1min, 4min, 8min are scored according to 4 point-scores, and (0 point of expression is non-stimulated, 1 point of expression slight stimulation, in 2 points of expressions Degree stimulation, 3 points of expression severe stimulations).Scores accumulated (M) refer to tired from the scoring score of 1min (M1), 4min (M4), 8min (M4) Add, formula M=M1+M4+M8.The results are shown in Table 1.

Table 1 is releived efficacy test table immediately

Group	0min	1min	4min	8min	Cumulative point (5 people)
						Blank	10	10	10	10	30
Embodiment 1	10	5	5	1	11
						Embodiment 2	10	5	6	0	11
Embodiment 3	10	5	5	1	11
						Embodiment 4	10	5	5	0	10
Comparative example 1	10	10	8	3	21
						Comparative example 2	10	10	7	3	20
Comparative example 3	10	10	8	4	22
						Comparative example 4	10	10	9	3	22
Comparative example 5	10	10	8	5	23
						Comparative example 6	10	10	8	4	22
Comparative example 7	10	10	8	5	23
						Comparative example 8	10	10	9	3	22
Comparative example 9	10	10	8	4	22
						Comparative example 10	10	10	7	4	21
Comparative example 11	10	10	8	5	23
						Comparative example 12	10	10	9	5	24
Comparative example 13	10	10	8	4	22

Note: numerical value is the scoring summation of 5 people in group in table.

As seen from the results in Table 1, the cumulative point of effect of releiving immediately in embodiment 1-4 be respectively 11 points, 11 points, 11 points and 10 points, the cumulative point of blank control is 30 points, there were significant differences for the cumulative point of embodiment 1-4 and blank control (P < 0.05), illustrate that hand lotion of the invention has very superior effect of releiving immediately.Effect of releiving immediately of comparative example 1-12 Cumulative point is 20 points -24 points, and dividing -11 split-phase ratios with the cumulative point 10 of embodiment 1-4, there were significant differences (P < 0.05), explanation If not preparing hand lotion according to ratio given to this invention, the superior effect of releiving immediately of embodiment will not be obtained.It is real A 1-4 is applied compared with comparative example 13 (commercially available Tayoi hand lotion), cumulative point equally has significant difference (P < 0.05), says Bright hand lotion of the invention has effects that good to releive immediately.

4. anti-chap test evaluation:

Study subject: choosing the age at 20-60 year old, 360 people of volunteer of hand skin chap, wherein male, female each 180 People is randomly divided into 18 groups, every group of 20 people (male, each 10 people of female), wherein blank control group (note: do not smear any by blank control group Product)；Embodiment 1-4 group；Contrast groups 1-13 group, all subjects did not smeared other systems such as any external drug or cosmetics Agent.

Experimental method: it under the conditions of 20 DEG C -25 DEG C of temperature, humidity are 50-60%, is smeared at subject's hand chap position Uniform one layer, daily morning uses 1 time, is used continuously 20 days, test result is shown in Table 2.

Note: (commercial product) frequency of use of comparative example 13 is 2 times a day, once in the morning and once at night.

Experimental standard: effect is divided into 4 grades:

Chapped skin is still without improvement in 0 grade: 20 day；

Chapped skin improves in 1 grade: 20 day；

Chapped skin improves in 2 grades: 15 days；

Chapped skin improves in 3 grades: 10 days；

Chapped skin improves in 4 grades: 5 days.

The anti-chap test evaluation effect of table 2

As seen from the results in Table 2,3 grades -4 grades of control group scoring of number is 0 people, 3 grades -4 grades of scoring in embodiment 1-4 group Number is 20 people respectively, illustrate embodiment 1-4 it is anti-chap test evaluation in effect to be significantly better than blank control (P < 0.05), illustrate that hand lotion of the invention has very superior anti-chap effect.Comparative example 1-12 and (the commercially available city of comparative example 13 Sell Tayoi hand lotion) 3 grades -4 grades or more of scoring of number (- 3 people of 0 people), in embodiment 1-4 group score 3 grades -4 grades Number (being 20 people) compared to there were significant differences (P < 0.05), illustrate if shield prepared by preparation method not according to the invention Hand frost, will not obtain superior anti-chap repairing effect.In addition, anti-chap effect of the invention and commercially available Tayoi hand lotion It compares.For embodiment 1-4 compared with comparative example 13, the number of 3 grades -4 grades or more of scoring equally has significant difference (P < 0.05), says Bright hand lotion of the invention has more superior effect.

5. moisturizing effect assessment, other efficacy assessments

The moisturizing effect of the hand lotion of embodiment 1-4 and comparative example 1-13 is evaluated by crowd's test on probation. The hand lotion for choosing embodiment 1-4 and comparative example 1-13 is tested.170 people of women for recruiting 20-60 years old, is divided into 17 groups, Every group of 10 people.Every morning smears both hands using 1 hand lotion, continuous 3 months on probation.Observe hand after subject tests Improvement situation evaluate the moisturizing effect and other hand effects of hand lotion.Other efficacy assessments results are using score System, every using effect grade are divided into 0-5 points, and 0 point is, entirely without effect, 1 point is possible there is part effect, but do not know, 2 points To there is certain effect, effect is unobvious, and 3 points are to have certain effect, and 4 points obvious for effect, but not significant, and 5 points obvious for effect And it is significant.

Moisture-keeping efficacy evaluation result is shown in Table 3, other efficacy assessments the results are shown in Table 4.

Note: (commercial product) frequency of use of comparative example 13 is 2 times a day, once in the morning and once at night.

The moisturizing efficacy assessments result of 3 hand lotion of table

As shown in Table 3, moisturizing effective percentage is respectively 80%, 90%, 90% and 100% in embodiment 1-4 group, and comparative example The effective percentage of 1-12 be 40%-60%, embodiment 1-4 moisturizing evaluation in effect to be significantly better than control group 1-12 (P < 0.05), show that hand lotion of the invention has very superior moistening effect.Illustrate condition preparation only according to the invention Hand lotion could obtain superior moistening effect of the invention.The efficient phase of comparative example 1-4 and comparative example 13 (commercial product) Than the moisturizing effective percentage of embodiment 1-4 is significantly higher than comparative example 13 (P < 0.05), illustrates the hand lotion ratio of condition preparation of the present invention Commercial product has superior moistening effect.

The evaluation of other clinical efficacies of table 4

As shown in Table 4, reparation evaluation coarse for hand skin, embodiment 1-4 is in the coarse reparation of hand skin Effect in evaluation will be significantly better than control group 1-12 (P < 0.05), show that hand lotion of the invention has very superior reparation The coarse effect of hand skin, also the hand lotion of explanation only condition according to the invention preparation could obtain of the invention superior Repair the coarse effect of hand skin.Embodiment 1-4 is compared with the coarse reparation evaluation of the hand skin of comparative example 13 (commercial product), The scoring of embodiment 1-4 is significantly higher than comparative example 13 (P < 0.05), illustrates that the hand lotion of condition preparation of the present invention compares commercial product With the coarse effect of superior reparation hand skin.

Hand redness is improved and is evaluated, embodiment 1-4, which improves the effect in evaluation in hand redness, will be significantly better than pair According to a group 1-12 (P < 0.05), show that hand lotion of the invention has very superior hand redness improvement, also explanation only has The hand lotion of condition preparation according to the invention could obtain superior hand redness improvement of the invention.Embodiment 1-4 Improve evaluation score with the hand redness of comparative example 13 (commercial product) to compare, the scoring of embodiment 1-4 is significantly higher than comparative example 13 (P < 0.05) illustrate that the hand lotion of condition preparation of the present invention has superior hand redness improvement than commercial product.

Hand skin lesion is improved and is evaluated, embodiment 1-4, which improves the effect in evaluation in hand skin lesion, will be significantly better than pair According to a group 1-12 (P < 0.05), show that hand lotion of the invention has very superior hand skin lesion improvement, also explanation only has The hand lotion of condition preparation according to the invention could obtain superior hand skin lesion improvement of the invention.Embodiment 1-4 Improve evaluation score with the hand skin lesion of comparative example 13 (commercial product) to compare, the scoring of embodiment 1-4 is significantly higher than comparative example 13 (P < 0.05) illustrate that the hand lotion of condition preparation of the present invention has superior hand skin lesion improvement than commercial product.

Hand whitening effect is evaluated, embodiment 1-4, which improves the effect in evaluation in hand skin lesion, will be significantly better than pair According to a group 1-12 (P < 0.05), show that hand lotion of the invention has very superior hand whitening effect, also illustrate only according to The hand lotion of condition preparation of the invention could obtain superior whitening effect of the invention.13 (the city embodiment 1-4 and comparative example Sell product) hand whitening effect evaluation score compare, the scoring of embodiment 1-4 is significantly higher than comparative example 13 (P < 0.05), says The hand lotion of bright condition preparation of the present invention has superior hand whitening effect than commercial product.

Skin elasticity effect assessment is restored for hand, embodiment 1-4 restores the effect in skin elasticity evaluation in hand It is significantly better than control group 1-12 (P < 0.05), shows that there is hand lotion of the invention very superior hand to restore skin elasticity Effect, also the hand lotion of explanation condition preparation only according to the invention could obtain superior hand recovery skin of the invention Elastic effect.Embodiment 1-4 restores skin elasticity effect assessment score with the hand of comparative example 13 (commercial product) and compares, and implements The scoring of example 1-4 is significantly higher than comparative example 13 (P < 0.05), illustrates that the hand lotion of condition preparation of the present invention has than commercial product Superior hand restores skin elasticity effect.

6. the skin sense of product is evaluated

By 8 by certain time training and the evaluation personnel with evaluating ability collectively constitutes evaluation group, age Between 25-45 years old.Above-mentioned 8 evaluation personnels respectively from the spreadability of product, moisten degree, absorbability, stick it is greasy degree, after feel etc. 5 aspects are evaluated.

It scores item by item according to standard, standards of grading are as shown in table 5.

Standards of grading are evaluated in 5 product skin sense of table

The calculation that total score is evaluated in skin sense is as follows:

Skin sense evaluation total score=spreadability * 20%+, which moistens degree * 20%+ trap * 20%+ and sticks after greasy degree * 20%+ is used, feels * 20%

The results are shown in Table 6.

6 skin sense evaluation table of table

As shown in Table 6, skin sense is evaluated, effect of the embodiment 1-4 in evaluation is all very excellent, evaluation total score difference It is 93.2,94.0,92.8,93.0.But the skin sense of comparative example 11 and comparative example 13 (commercial product) evaluation scoring and embodiment The score value difference of 1-4 is obvious, is 82.8 points and 80.4 points.To sum up, illustrate that hand lotion skin sense of the invention is superior, consumer can be given Bring good usage experience.

There are many concrete application approach of the present invention, the above is only a preferred embodiment of the present invention.More than it should be pointed out that Embodiment is merely to illustrate the present invention, and the protection scope being not intended to restrict the invention.For the common skill of the art For art personnel, without departing from the principle of the present invention, several improvement can also be made, these improvement also should be regarded as this hair Bright protection scope.

Claims (10)

1. a kind of herb fermenting object, which is characterized in that each effective component including following parts by weight: 25-30 parts of Radix Notoginseng, camellia 15-20 parts of leaf, 12-20 parts of Radix Glycyrrhizae, 15-20 parts of pawpaw, 15-20 parts of Radix Salviae Miltiorrhizae, 15-20 parts of safflower, 12-18 parts of Radix Angelicae Sinensis, folium artemisiae argyi 20-25 parts, 25-30 parts of sea-buckthorn, 10-15 parts of tuniclike psammosilene root, 15-20 parts of aloe, 25-30 parts of lotus leaf, 12-18 parts of mulberry fruit, fructus lycii 10-15 parts, 12-18 parts of ginkgo leaf, 15-20 parts of Asian puccoon, 15-20 parts of radix scutellariae, 20-25 parts of Cortex Magnoliae Officinalis.

2. a kind of preparation method of herb fermenting object according to claim 1, which comprises the following steps:

A, each effective component described in claim 1 is weighed in proportion, and weighs wheat bran, dregs of beans；

B, after mixing the weighed each component of step A, deionized water, sugar, potassium dihydrogen phosphate, dipotassium hydrogen phosphate and chlorination is added Sodium, and be inoculated with S. cervisiae and carry out anaerobic fermentation；

C, high-temperature sterilization is carried out after fermentation, is filtered, gained filtrate is the herb fermenting object.

3. the preparation method of herb fermenting object according to claim 2, which is characterized in that in step A, the wheat bran adds Enter 25% that amount is each effective component total amount, the additional amount of the dregs of beans is the 15% of each effective component total amount.

4. the preparation method of herb fermenting object according to claim 2, which is characterized in that in step B, the saccharomyces cerevisiae The inoculum concentration of bacterium is 5-8%, and the concentration of S. cervisiae is 2 × 10⁶CFU/mL。

5. the preparation method of herb fermenting object according to claim 2, which is characterized in that in step B, the anaerobic fermentation Temperature be 28-30 DEG C, fermentation time 24-48h.

6. a kind of herb fermenting object according to claim 1 is preparing the application in hand lotion.

7. a kind of hand lotion, which is characterized in that each component including following parts by weight: herb fermenting described in claim 1 30-50 parts of object, 1-3 parts of camellia seed oil, 1-5 parts of half saualane extraction oil of safflower, 1-5 parts of half saualane extraction oil of folium artemisiae argyi, mountain How stearic 1-5 parts of camellia saualane extraction oil, 1-5 parts of Radix Salviae Miltiorrhizae saualane extraction oil, 1-5 parts of Radix Angelicae Sinensis saualane extraction oil, sucrose is 1-3 parts of acid esters, 0.1-1 parts of inulin lauryl carbamate, 1-5 parts of 1,3-BDO, 0.5-3 parts of 1,2- pentanediol, 1,2- 0.5-3 parts of hexylene glycol, II0.01-0.5 parts of ceramide, 0.1-5 parts of hydrolecithin, Retinol Palmitate 0.1-0.5 Part, 0.2-2 parts of modified tapioca starch, 0.2-1 parts of parahydroxyacet-ophenone, 0.01-0.05 parts of EDTA- disodium, xanthan gum 0.1-0.5 Part, 35-50 parts of deionized water, 0.01-0.05 parts of essence.

8. hand lotion according to claim 7, which is characterized in that the half saualane extraction oil of safflower passes through following Method preparation: safflower is appropriate after weighing drying, and after crushing crusher machine, the sieving of 200 mesh is set according to the ratio of 0.1-0.5g/ml In half saualane, 24-48h is extracted under the conditions of vacuum -0.06MPa, then in 40-55 DEG C of ultrasonic extraction 4-6h, filtering takes filter Liquid to get；

The half saualane extraction oil of folium artemisiae argyi is prepared by the following method: camellia is appropriate after weighing drying, after crushing crusher machine, The sieving of 200 mesh, is placed in half saualane according to the ratio of 0.1-0.5g/ml, extracts 24-48h under the conditions of vacuum -0.06MPa, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

9. hand lotion according to claim 7, which is characterized in that the camellia saualane extraction oil passes through with lower section Method preparation: folium artemisiae argyi is appropriate after weighing drying, and after crushing crusher machine, the sieving of 200 mesh is placed in angle according to the ratio of 0.2-0.7g/ml In shark alkane, extract 24-48h under the conditions of vacuum -0.06MPa, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

The Radix Salviae Miltiorrhizae saualane extraction oil is prepared by the following method: Radix Salviae Miltiorrhizae is appropriate after weighing drying, after crushing crusher machine, The sieving of 200 mesh, is placed in saualane according to the ratio of 0.2-0.7g/ml, extracts 24-48h under the conditions of vacuum -0.06MPa, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

The Radix Angelicae Sinensis saualane extraction oil is prepared by the following method: Radix Angelicae Sinensis is appropriate after weighing drying, after crushing crusher machine, The sieving of 200 mesh, is placed in saualane according to the ratio of 0.2-0.7g/ml, extracts 24-48h under the conditions of vacuum -0.06MPa, in 40-55 DEG C of ultrasonic extraction 4-6h, filtering, take filtrate to get.

10. a kind of preparation method of hand lotion according to claim 7, which comprises the following steps:

S1, camellia seed oil, half saualane extraction oil of safflower, half saualane extraction oil of folium artemisiae argyi, camellia spiny dogfish are weighed in proportion Alkane extraction oil, Radix Salviae Miltiorrhizae saualane extraction oil, Radix Angelicae Sinensis saualane extraction oil, Sucrose Polystearic Acid Esters, inulin lauryl aminocarbamic acid Ester, ceramide II, hydrolecithin, Retinol Palmitate are placed in a beaker in holding 75-90 DEG C of water of temperature on water-bath Heating melting is bathed, as oily phase；

S2, deionized water, herb fermenting object, xanthan gum, parahydroxyacet-ophenone, EDTA- disodium are weighed in proportion be placed in 75-90 DEG C Heating water bath stirs evenly, until being completely dissolved, obtains water phase；

S3, water phase is poured into oily phase, stirs homogeneous to paste, obtains matrix, then cool down；

S4, modified tapioca starch, 1,3-BDO, 1,2- pentanediol, 1,2- hexylene glycol are weighed in proportion, stir into milk；

S5, the milk that in the matrix that step S3 is obtained prepared by addition step S4, add essence, homogeneous is to get the shield Hand frost.