CN110396040A - 一种一锅法合成二芳基甲缩酮的方法 - Google Patents
一种一锅法合成二芳基甲缩酮的方法 Download PDFInfo
- Publication number
- CN110396040A CN110396040A CN201910845875.4A CN201910845875A CN110396040A CN 110396040 A CN110396040 A CN 110396040A CN 201910845875 A CN201910845875 A CN 201910845875A CN 110396040 A CN110396040 A CN 110396040A
- Authority
- CN
- China
- Prior art keywords
- ketal
- diaryl
- reaction
- method described
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910845875.4A CN110396040B (zh) | 2019-09-09 | 2019-09-09 | 一种一锅法合成二芳基甲缩酮的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910845875.4A CN110396040B (zh) | 2019-09-09 | 2019-09-09 | 一种一锅法合成二芳基甲缩酮的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN110396040A true CN110396040A (zh) | 2019-11-01 |
CN110396040B CN110396040B (zh) | 2020-12-15 |
Family
ID=68328399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910845875.4A Active CN110396040B (zh) | 2019-09-09 | 2019-09-09 | 一种一锅法合成二芳基甲缩酮的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110396040B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112500267A (zh) * | 2020-12-04 | 2021-03-16 | 江苏慧聚药业有限公司 | 4-溴-2-(4’-乙氧基-苄基)-1-氯苯的制备 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997034860A1 (en) * | 1996-03-15 | 1997-09-25 | Consiglio Nazionale Delle Ricerche | A PROCESS FOR THE PREPARATION OF α-ARYLPROPIONIC ACIDS AND THE INTERMEDIATES THEREOF |
CN101948503A (zh) * | 2010-09-10 | 2011-01-19 | 天津金汇药业集团有限公司 | 常温均相反应制备倍他米松缩酮物的方法 |
US20170029398A1 (en) * | 2014-03-06 | 2017-02-02 | Srinivasan Thirumalai Rajan | Process for the preparation of (1s)-1,5-anhydro-1-c-{4-chloro-3-4[(4-ethoxyphenyl)methyl]phenyl]-glucitol and its solvate thereof |
CN108530408A (zh) * | 2018-04-13 | 2018-09-14 | 海门慧聚药业有限公司 | 制备达格列净的方法 |
-
2019
- 2019-09-09 CN CN201910845875.4A patent/CN110396040B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997034860A1 (en) * | 1996-03-15 | 1997-09-25 | Consiglio Nazionale Delle Ricerche | A PROCESS FOR THE PREPARATION OF α-ARYLPROPIONIC ACIDS AND THE INTERMEDIATES THEREOF |
CN101948503A (zh) * | 2010-09-10 | 2011-01-19 | 天津金汇药业集团有限公司 | 常温均相反应制备倍他米松缩酮物的方法 |
US20170029398A1 (en) * | 2014-03-06 | 2017-02-02 | Srinivasan Thirumalai Rajan | Process for the preparation of (1s)-1,5-anhydro-1-c-{4-chloro-3-4[(4-ethoxyphenyl)methyl]phenyl]-glucitol and its solvate thereof |
CN108530408A (zh) * | 2018-04-13 | 2018-09-14 | 海门慧聚药业有限公司 | 制备达格列净的方法 |
Non-Patent Citations (1)
Title |
---|
MARK C. WILKINSON等: "Application of the Catalytic Friedel–Crafts Acylation Reaction and Regioselectivity Correlations", 《SYNLETT》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112500267A (zh) * | 2020-12-04 | 2021-03-16 | 江苏慧聚药业有限公司 | 4-溴-2-(4’-乙氧基-苄基)-1-氯苯的制备 |
WO2022116507A1 (zh) * | 2020-12-04 | 2022-06-09 | 江苏慧聚药业有限公司 | 4-溴-2-(4'-乙氧基-苄基)-1-氯苯的制备 |
US11565990B2 (en) | 2020-12-04 | 2023-01-31 | Wisdom Pharmaceutical Co., Ltd | Preparation of 4-bromo-2-(4′-ethoxyphenyl)-1-chlorobenzene |
Also Published As
Publication number | Publication date |
---|---|
CN110396040B (zh) | 2020-12-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Cox et al. | Expedient route to 3-and 3, 3′-substituted 1, 1′-bi-2-naphthols by directed ortho metalation and suzuki cross coupling methods | |
Zhang et al. | Enantioselective allylic substitution of Morita–Baylis–Hillman adducts catalyzed by planar chiral [2.2] paracyclophane monophosphines | |
Fujita et al. | Carboxylative cyclization of propargylic amines with CO2 catalyzed by dendritic N-heterocyclic carbene–gold (I) complexes | |
Hermeke et al. | Phosphonium ion tagged chiral phosphoric acids and their application in Friedel–Crafts reactions of indoles | |
Xu et al. | Highly efficient phosphine-catalyzed aza-Michael reactions of α, β-unsaturated compounds with carbamates in the presence of TMSCl | |
CN102753018A (zh) | 苯并呋喃的制备及其作为合成中间体的用途 | |
Akondi et al. | Ce/SiO2 composite as an efficient catalyst for the multicomponent one-pot synthesis of substituted pyrazolones in aqueous media and their antimicrobial activities | |
Patil et al. | CES as an efficient natural catalyst for synthesis of Schiff bases under solvent-free conditions: an innovative green approach | |
Dindulkar et al. | Cd (ClO4) 2∙ xH2O as a novel catalyst for the synthesis of α-aminophosphonates under solvent-free conditions | |
Qi et al. | Synthesis of novel chiral oxazoline-Schiff base ligands for the catalytic asymmetric chlorination of β-keto esters | |
CN110396040A (zh) | 一种一锅法合成二芳基甲缩酮的方法 | |
CN106000465B (zh) | 一种醛与二级酰胺的氧化偶联反应的方法 | |
CN103694204B (zh) | 一种1,2,4-三取代呋喃类化合物及其制备方法 | |
Bajwa et al. | In-situ generation of Et3SiBr from BiBr3 and Et3SiH and its use in preparation of dialkyl ethers | |
CN100509728C (zh) | 一种芳基甲基醚的脱甲基方法 | |
CN102863361B (zh) | 甲砜霉素的手性催化合成方法 | |
Banerjee et al. | Cerium (IV) ammonium nitrate-catalyzed synthesis of β-keto enol ethers from cyclic β-diketones and their deprotection | |
Rajendran et al. | A domino green synthesis of bis (indolyl) methanes catalyzed by ionic liquid [Et3NH][HSO4] | |
CN108218798A (zh) | Apabetalone的制备方法 | |
Batista et al. | Synthesis and characterization of the mer-[RuCl3 (NO)(dppb)] isomer. X-ray structures of fac-[RuCl3 (NO)(dppm)], cis-[RuCl2 (dppm) 2] and mer-[RuCl3 (NO)(dppb)][dppm= 1, 2-bis (diphenylphosphino) methane and dppb= 1, 4-bis (diphenylphosphino) butane] | |
CN106083759B (zh) | 一种芦曲泊帕的全新合成工艺 | |
CN101007754A (zh) | 一种高三蝶烯类化合物及其制备方法 | |
Bottaro et al. | Improved synthesis of cubane-1, 2, 4, 7-tetracarboxylic acid | |
Mahdavinia | Clean synthesis of 1, 8-dioxo-octahydroxanthene derivatives using NBS as an efficient and almost neutral catalyst in aqueous media | |
Wang et al. | Liquid-phase parallel synthesis of 2-aryl-5-methoxylcarbonyl-dihydropyrones using soluble polymer support |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 210096, No. four archway, Xuanwu District, Jiangsu, Nanjing 2 Patentee after: SOUTHEAST University Patentee after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 210096, No. four archway, Xuanwu District, Jiangsu, Nanjing 2 Patentee before: SOUTHEAST University Patentee before: WISDOM PHARMACEUTICAL Co.,Ltd. Address after: 210096, No. four archway, Xuanwu District, Jiangsu, Nanjing 2 Patentee after: SOUTHEAST University Patentee after: Jiangsu Huiju Pharmaceutical Co.,Ltd. Address before: 210096, No. four archway, Xuanwu District, Jiangsu, Nanjing 2 Patentee before: SOUTHEAST University Patentee before: Jiangsu Huiju Pharmaceutical Co.,Ltd. |