CN110393690A - 一种减缓皮肤糖化的修护精华及其制备方法 - Google Patents
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Abstract
本发明涉及化妆品技术领域,公开了一种减缓皮肤糖化的修护精华,包括质量百分比的以下组分:甘油1~5%;丙二醇1~5%;透明质酸钠0.05~0.3%;聚谷氨酸钠0.01~0.1%;水解小核菌(SCLEROTIUM ROLFSSII)胶0.05~0.4%;甜菜碱1~3%;卡波姆0.1~0.5%;三乙醇胺0.1~0.5%;麦芽糖醇1~5%;β‑葡聚糖0.05~0.5%;肌肽0.01~0.05%;植舒敏0.1~0.5%;超氧化物歧化酶(SOD)1~5%;酵母提取物1~3%;胶原0.02~0.05%;对羟基苯乙酮0.1~0.4%;双(羟甲基)咪唑烷基脲0.2~0.4%;香精0.0002~0.0004%;CI 191400.0005~0.001%;去离子水余量。本发明通过多种功效原料复合达到调理和修护肌肤糖基化问题,使肌肤弹润透亮。
Description
技术领域
本发明涉及化妆品技术领域,更具体的说是涉及一种减缓皮肤糖化的修护精华及其制备方法。
背景技术
由于生活环境大大的改变,消费者的作息时间不规律以及护肤类产品的过度使用等问题,导致消费者的皮肤变得越来越脆弱,皮肤越来越多的蛋白质被糖基化,糖基化速率加快,致使皮肤出现萎缩,失去弹性,形成皱纹与沟槽,且会使皮肤蜡黄无光泽。针对该类问题,有必要研发一款减缓皮肤糖化的修护精华,能有效减缓皮肤糖基化,修护肌肤,令肌肤弹润透亮。
发明内容
为了解决以上技术问题,本发明提供一种减缓皮肤糖化的修护精华及其制备方法,修护、减缓因皮肤过度使用造成皮肤糖化,衰老速率加快的肌肤问题,修护肌肤,令肌肤弹润透亮。
为实现上述目的,本发明提供如下技术方案:
一种减缓皮肤糖化的修护精华,包括质量百分比的以下组分:
优选地,所述植舒敏包括质量百分比的以下组分:库拉索芦荟提取物20%;金黄洋甘菊提取物30%;马齿苋提取物40%;香叶天竺葵提取物8.8%;1,2-己二醇0.6%;对羟基苯乙酮0.6%。植舒敏是舒缓修护有效成分。
上述修护精华的优选配方包括质量百分比的以下组分:
本发明的另一目的在于公开上述减缓皮肤糖化的修护精华的制备方法,包括以下步骤:
(1)将甘油、丙二醇、透明质酸钠、聚谷氨酸钠、水解小核菌(SCLEROTIUMROLFSSII)胶、甜菜碱、卡波姆、去离子水投入主乳化锅中,加热至80~85℃,搅拌、开启均质溶解至透明状;
(2)搅拌降温至50℃,将三乙醇胺和麦芽糖醇分别加入主乳化锅中搅拌均匀;
(3)继续搅拌降温至40℃,加入β-葡聚糖、肌肽、植舒敏、超氧化物歧化酶(SOD)、酵母提取物、胶原、对羟基苯乙酮、双(羟甲基)咪唑烷基脲、香精和CI 19140,搅拌均匀;
(4)半成品检验合格后,过滤出料;
(5)储存、灌装、包装、成品检验、入库。
与现有技术相比,本发明有益之处在于:
本发明通过植舒敏和肌肽复合达到调理和修护肌肤糖基化问题,使肌肤弹润透亮。
本发明的修复精华能有效抑制刺激性强的表面活性剂、溶剂带来的红斑。
本发明的修复精华能有效减缓皮肤糖基化,修护肌肤,修复和减少鱼尾纹。
附图说明
图1为实施例1中0-3天使用安慰剂、空白和本发明产品处理过的皮肤示意图;
图2为实施例1二维灰度和3D模糊图像分析使用本发明产品前后志愿者前鱼尾纹情况示意图;
图3为实施例1使用本发明产品前后志愿者鱼尾纹对比示意图。
具体实施方式
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
一种减缓皮肤糖化的修护精华,包括质量百分比的以下组分:
甘油3%;丙二醇3%;透明质酸钠0.1%;聚谷氨酸钠0.03%;水解小核菌(SCLEROTIUM ROLFSSII)胶0.1%;甜菜碱1%;卡波姆0.13%;三乙醇胺0.13%;麦芽糖醇2%;β-葡聚糖0.05%;肌肽0.02%;植舒敏0.3%;超氧化物歧化酶(SOD)3%;酵母提取物1%;胶原0.02%;对羟基苯乙酮0.2%;双(羟甲基)咪唑烷基脲0.3%;香精0.0002%;CI19140 0.00074%;去离子水余量。
其中,所述植舒敏包括质量百分比的以下组分:库拉索芦荟提取物20%;金黄洋甘菊提取物30%;马齿苋提取物40%;香叶天竺葵提取物8.8%;1,2-己二醇0.6%;对羟基苯乙酮0.6%。植舒敏是舒缓修护有效成分。
上述减缓皮肤糖化的修护精华的制备方法,包括以下步骤:
(1)将甘油、丙二醇、透明质酸钠、聚谷氨酸钠、水解小核菌(SCLEROTIUMROLFSSII)胶、甜菜碱、卡波姆、去离子水投入主乳化锅中,加热至80~85℃,搅拌、开启均质溶解至透明状;
(2)搅拌降温至50℃,将三乙醇胺和麦芽糖醇分别加入主乳化锅中搅拌均匀;
(3)继续搅拌降温至40℃,加入β-葡聚糖、肌肽、植舒敏、超氧化物歧化酶(SOD)、酵母提取物、胶原、对羟基苯乙酮、双(羟甲基)咪唑烷基脲、香精和CI 19140,搅拌均匀;
(4)半成品检验合格后,过滤出料;
(5)储存、灌装、包装、成品检验、入库。
一、临床体外测试方式:双盲测试方法
测试对象(成人手臂内侧皮肤)
破坏性实验(用12%的十二烷基硫酸钠溶液封闭6小时),然后将安慰剂、空白、本实施例1制得的修护精华分别涂在成人手臂内侧皮肤,使用时间为3天。
结果如图1所示:其中,A是安慰剂处理过的皮肤,B是空白对照,C是实施例1制得的修护精华处理过的皮肤。
实验证明:本发明的修复精华能有效抑制刺激性强的表面活性剂、溶剂带来的红斑。
二、使用效果测试
35名受试者(年龄30~70岁),眼角有明显鱼尾纹,每天两次涂抹0.5g实施例1制得的修护精华,持续四周。
1、使用4周后,受试者鱼尾纹得到显著改善,Ra(平均粗糙度)和Rz(平均深度)均显示出明显的减小趋势,如表1所示:
表1使用后志愿者眼眶区域皱纹Ra(平均粗糙度)和Rz(平均深度)减小的百分率
N/A,not applicable.
*P-value compared to no treatment control.
2、如图2所示,通过二维灰度和3D模糊图像分析,评价使用四周后与使用前鱼尾纹情况。结果显示,与使用前比较,受试者涂抹实施例1制得的修护精华四周后鱼尾纹深度变浅、长度缩短。
3、四周后,志愿者拍摄眼角高清照片评估皮肤状况,涂抹肌肽产品后眼角鱼尾纹数目显著减少,深度明显变浅,如图3所示。
实施例2
一种减缓皮肤糖化的修护精华,包括质量百分比的以下组分:
甘油1%;丙二醇5%;透明质酸钠0.3%;聚谷氨酸钠0.01%;水解小核菌(SCLEROTIUM ROLFSSII)胶0.4%;甜菜碱1%;卡波姆0.5%;三乙醇胺0.1%;麦芽糖醇5%;β-葡聚糖0.5%;肌肽0.01%;植舒敏0.5%;超氧化物歧化酶(SOD)1%;酵母提取物3%;胶原0.02%;对羟基苯乙酮0.4%;双(羟甲基)咪唑烷基脲0.2%;香精0.0004%;CI 191400.0005%;去离子水余量。
其中,所述植舒敏包括质量百分比的以下组分:库拉索芦荟提取物20%;金黄洋甘菊提取物30%;马齿苋提取物40%;香叶天竺葵提取物8.8%;1,2-己二醇0.6%;对羟基苯乙酮0.6%。植舒敏是舒缓修护有效成分。
上述减缓皮肤糖化的修护精华的制备方法,包括以下步骤:
(1)将甘油、丙二醇、透明质酸钠、聚谷氨酸钠、水解小核菌(SCLEROTIUMROLFSSII)胶、甜菜碱、卡波姆、去离子水投入主乳化锅中,加热至80~85℃,搅拌、开启均质溶解至透明状;
(2)搅拌降温至50℃,将三乙醇胺和麦芽糖醇分别加入主乳化锅中搅拌均匀;
(3)继续搅拌降温至40℃,加入β-葡聚糖、肌肽、植舒敏、超氧化物歧化酶(SOD)、酵母提取物、胶原、对羟基苯乙酮、双(羟甲基)咪唑烷基脲、香精和CI 19140,搅拌均匀;
(4)半成品检验合格后,过滤出料;
(5)储存、灌装、包装、成品检验、入库。
一、临床体外测试方式:双盲测试方法,如实施例1所示。
二、使用效果测试,如实施例1所示。
实施例3
一种减缓皮肤糖化的修护精华,包括质量百分比的以下组分:
甘油5%;丙二醇1%;透明质酸钠0.05%;聚谷氨酸钠0.1%;水解小核菌(SCLEROTIUM ROLFSSII)胶0.05%;甜菜碱3%;卡波姆0.1%;三乙醇胺0.5%;麦芽糖醇1%;β-葡聚糖0.05%;肌肽0.05%;植舒敏0.1%;超氧化物歧化酶(SOD)5%;酵母提取物1%;胶原0.05%;对羟基苯乙酮0.1%;双(羟甲基)咪唑烷基脲0.4%;香精0.0002%;CI19140 0.001%;去离子水余量。
其中,所述植舒敏包括质量百分比的以下组分:库拉索芦荟提取物20%;金黄洋甘菊提取物30%;马齿苋提取物40%;香叶天竺葵提取物8.8%;1,2-己二醇0.6%;对羟基苯乙酮0.6%。植舒敏是舒缓修护有效成分。
上述减缓皮肤糖化的修护精华的制备方法,包括以下步骤:
(1)将甘油、丙二醇、透明质酸钠、聚谷氨酸钠、水解小核菌(SCLEROTIUMROLFSSII)胶、甜菜碱、卡波姆、去离子水投入主乳化锅中,加热至80~85℃,搅拌、开启均质溶解至透明状;
(2)搅拌降温至50℃,将三乙醇胺和麦芽糖醇分别加入主乳化锅中搅拌均匀;
(3)继续搅拌降温至40℃,加入β-葡聚糖、肌肽、植舒敏、超氧化物歧化酶(SOD)、酵母提取物、胶原、对羟基苯乙酮、双(羟甲基)咪唑烷基脲、香精和CI 19140,搅拌均匀;
(4)半成品检验合格后,过滤出料;
(5)储存、灌装、包装、成品检验、入库。
一、临床体外测试方式:双盲测试方法,如实施例1所示。
二、使用效果测试,如实施例1所示。
对所公开的实施例的上述说明,使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的,本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下,在其它实施例中实现。因此,本发明将不会被限制于本文所示的这些实施例,而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。
Claims (4)
1.一种减缓皮肤糖化的修护精华,其特征在于,包括质量百分比的以下组分:
2.根据权利要求1所述的一种减缓皮肤糖化的修护精华,其特征在于,所述植舒敏包括质量百分比的以下组分:库拉索芦荟提取物20%;金黄洋甘菊提取物30%;马齿苋提取物40%;香叶天竺葵提取物8.8%;1,2-己二醇0.6%;对羟基苯乙酮0.6%。
3.根据权利要求1所述的一种减缓皮肤糖化的修护精华,其特征在于,包括质量百分比的以下组分:
4.如权利要求1-3任一项所述减缓皮肤糖化的修护精华的制备方法,其特征在于,包括以下步骤:
(1)将甘油、丙二醇、透明质酸钠、聚谷氨酸钠、水解小核菌(SCLEROTIUM ROLFSSII)胶、甜菜碱、卡波姆、去离子水投入主乳化锅中,加热至80~85℃,搅拌、开启均质溶解至透明状;
(2)搅拌降温至50℃,将三乙醇胺和麦芽糖醇分别加入主乳化锅中搅拌均匀;
(3)继续搅拌降温至40℃,加入β-葡聚糖、肌肽、植舒敏、超氧化物歧化酶(SOD)、酵母提取物、胶原、对羟基苯乙酮、双(羟甲基)咪唑烷基脲、香精和CI 19140,搅拌均匀;
(4)半成品检验合格后,过滤出料;
(5)储存、灌装、包装、成品检验、入库。
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