CN110368591A - Microwaves roasting treatment instrument for cancer - Google Patents
Microwaves roasting treatment instrument for cancer Download PDFInfo
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- CN110368591A CN110368591A CN201910715216.9A CN201910715216A CN110368591A CN 110368591 A CN110368591 A CN 110368591A CN 201910715216 A CN201910715216 A CN 201910715216A CN 110368591 A CN110368591 A CN 110368591A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/02—Radiation therapy using microwaves
- A61N5/022—Apparatus adapted for a specific treatment
- A61N5/025—Warming the body, e.g. hyperthermia treatment
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Abstract
The invention discloses a kind of microwaves roasting treatment instrument for cancer, belong to electromagnetism technical field for cancer.Including electromagnetic wave generating device, electromagnetic wave orienting device, best electromagnetic wave irradiation device for calculating and electromagnetic wave output-controlling device, the electromagnetic wave output-controlling device is electrically connected with the electromagnetic wave generating device, electromagnetic wave generating device exports the electromagnetic wave of ISM band, and the exposure for inducing superficial tumor Apoptosis is calculated according to the relationship approximate function between electromagnetic wave irradiation amount and tumour cell survival rate for best electromagnetic wave irradiation device for calculating.Best electromagnetic wave irradiation amount can be calculated, and by the orientation output of electromagnetic wave orienting device, quantitative, precisely irradiation is carried out to tumor section, improves therapeutic effect.
Description
Technical field
The present invention relates to a kind of microwaves roasting treatment instrument for cancer, belong to electromagnetism technical field for cancer.
Background technique
Thermotherapy, which refers to by the way that certain a part of body is heated to 39-43 DEG C or so of method, treats controlling for the diseases such as tumour
Treatment mode.Usually heated using electromagnetic waves such as RF wave, microwaves.
The principle of electromagnetic wave thermotherapy is as follows: electromagnetic wave irradiation can be such that electronic cell vibrates, and rubs mutually generates between molecule
Heat heats normal cell and cancer cell.After normal cell heating, it can be rapidly decreased to just by the blood flow of normal blood vessels
Normal temperature.And washiness in cancer cell, nagiopasthyrosis, blood flow are few, are easy heating but are difficult to cool down.Therefore, only cancer cell
It can be destroyed because of heating.Meanwhile thermotherapy can promote blood operation while improving immunity, mention by heating normal cell
The activity of high each organ in vivo.But excessive exposure may make normal cell thermally damaged.
How while preventing excessive exposure, thermotherapy is effectively carried out, many schemes have been proposed at present.
For example, a kind of existing thermal therapy system for for malignant tumour.The system use intensity is the magnetostatic of 0.5-9T
, the promotion of temperature is detected by MR hygrogram, is realized to the thermotherapy monitoring at 42-43 DEG C, is used the microwave of 0.4-3GHz
Generator generates microwave, and the heating temperature of target site is controlled using the intermittence ON & OFF of power switch.
There are also a kind of thermotherapeutic apparatus, shine by the electromagnetic wave generating device of exportable electromagnetic wave and by resulting electromagnetic wave
The irradiation unit composition being mapped on living body.In electromagnetic wave generating device, the position temperature of detection heating at regular intervals joined
The temperature measuring device of degree and the control device that output quantity can be reduced, when temperature measuring device detects that vital body temperature is more than
When predetermined temperature, output-controlling device can control and reduce the output quantity of aforementioned electromagnetic wave generation device.
In addition there are a kind of therapeutic device using micro-wave therapeutic skin histology, by the treatment face of positioning therapentic part, preceding
Multiple radiation devices on the treatment face of stating and the power supply unit of microwave energy transfer to aforementioned radiation device is formed.It is aforementioned to put
Emitter part can be used as electromagnetic field, and microwave energy is gone out by aforementioned therapies surface radiation, in therapeutic process, can produce uniform electromagnetism
, depth is preset with penetrate into therapentic part.In addition it is further equipped with motional impedance integral unit in hyperthermia heat device,
The impedance for radiating device and the skin histology impedance at position to be treated can be integrated based on the monitoring information of monitoring unit,
Control the output electricity of power amplifier.
Although the above method realizes technique for hyperthermia, various shortcomings are remained.
Summary of the invention
Technical problem to be solved by the present invention lies in: a kind of microwaves roasting treatment instrument for cancer is provided, can be calculated most
Good electromagnetic wave irradiation amount, and by the orientation output of electromagnetic wave orienting device, quantitative, precisely irradiation is carried out to tumor section, is improved
Therapeutic effect.
The technical problems to be solved by the invention take following technical scheme to realize:
Microwaves roasting treatment instrument for cancer, including electromagnetic wave generating device, electromagnetic wave orienting device, best electromagnetic wave irradiation amount calculate dress
It sets and is electrically connected with electromagnetic wave output-controlling device, the electromagnetic wave output-controlling device with the electromagnetic wave generating device, electromagnetic wave
Generating device exports the electromagnetic wave of ISM band, and best electromagnetic wave irradiation device for calculating is thin according to electromagnetic wave irradiation amount and tumour
The exposure for inducing superficial tumor Apoptosis is calculated in relationship approximate function between born of the same parents' survival rate.
It further include the fixed device of living body as preferred embodiment.
As preferred embodiment, the process for inducing the exposure of epidermal cell apoptosis is calculated are as follows:
Using the culture medium after the electromagnetic wave irradiation implanted tumor cells of ISM band, electromagnetic wave irradiation amount and tumour cell are measured
Relationship between survival rate determines the relationship approximate function between electromagnetic wave irradiation amount and tumour cell survival rate, utilizes the pass
It is that approximate function calculates the best electromagnetic wave irradiation amount for inducing superficial tumor Apoptosis.
As preferred embodiment, the relationship approximate function is the letter based on one-hit multitarget model or straight line conic model
Number.
As preferred embodiment, the centre frequency for irradiating the electromagnetic wave of implanted tumor cells is 2450MHz.
As preferred embodiment, wherein relationship approximate function includes that the size of the culture medium of implanted tumor cells and body surface are swollen
Relationship, tumour cell survival rate between oncocyte size and the relationship between the size of the culture medium of implanted tumor cells
And/or the relationship between tumour cell survival rate and the size of superficial tumor cell.
As preferred embodiment, wherein relationship approximate function includes the relationship between electromagnetic wave irradiation amount and culture medium temperature
And/or the relationship between tumour cell survival rate and culture medium temperature.
The beneficial effects of the present invention are: best electromagnetic wave irradiation amount can be calculated, and pass through electromagnetic wave orienting device
Orientation output carries out quantitative, precisely irradiation to tumor section, improves therapeutic effect.
Detailed description of the invention
Fig. 1 is the principle of the present invention block diagram；
Relation schematic diagram of the Fig. 2 between electromagnetic wave irradiation amount (periodicity) and tumour cell survival rate；
Relation schematic diagram of the Fig. 3 between electromagnetic wave irradiation amount (periodicity) and temperature；
Fig. 4 is influence schematic diagram of the electromagnetic wave irradiation to tumour cell breeding potential；
Fig. 5 is implementation diagram of the present invention；
Relation schematic diagram of the Fig. 6 between temperature and cancer cell killing；
Therapeutic effect contrast schematic diagram of the Fig. 7 between different treatment means；
Therapeutic effect contrast table of the Fig. 8 between different treatment means.
In figure: microwaves roasting treatment instrument 1 for cancer, operator 2, animal 3, operating table 4.
Specific embodiment
In order to be easy to understand to technical means, creative features, achievable purpose and effectiveness of the invention, below with reference to tool
Body diagram, the present invention is further explained.
As shown in Figure 1, microwaves roasting treatment instrument for cancer, including electromagnetic wave generating device, electromagnetic wave orienting device, best electromagnetism
Wave exposure computing device and electromagnetic wave output-controlling device, the electromagnetic wave output-controlling device are filled with the electromagnetic wave
It sets and is electrically connected, electromagnetic wave generating device exports the electromagnetic wave of ISM band, and best electromagnetic wave irradiation device for calculating shines according to electromagnetic wave
The exposure for inducing superficial tumor Apoptosis is calculated in relationship approximate function between the amount of penetrating and tumour cell survival rate.
Further, further include the fixed device of living body, experiment body is fixed.
Further, the process for inducing the exposure of epidermal cell apoptosis is calculated are as follows:
Using the culture medium after the electromagnetic wave irradiation implanted tumor cells of ISM band, electromagnetic wave irradiation amount and tumour cell are measured
Relationship between survival rate determines the relationship approximate function between electromagnetic wave irradiation amount and tumour cell survival rate, utilizes the pass
It is that approximate function calculates the best electromagnetic wave irradiation amount for inducing superficial tumor Apoptosis.
Further, the relationship approximate function is the function based on one-hit multitarget model or straight line conic model.
Further, the centre frequency for irradiating the electromagnetic wave of implanted tumor cells is 2450MHz.
Further, wherein relationship approximate function includes that the size of the culture medium of implanted tumor cells and superficial tumor are thin
Relationship, tumour cell survival rate between born of the same parents' size and the relationship between the size of the culture medium of implanted tumor cells and/or
Relationship between tumour cell survival rate and the size of superficial tumor cell.
Further, wherein relationship approximate function include relationship between electromagnetic wave irradiation amount and culture medium temperature and/or
Relationship between tumour cell survival rate and culture medium temperature.
The electromagnetic wave of ISM band is ITU(International Telecommunication Union) specified industry, science, medical Special electromagnetic wave frequency section.
Specifically, i.e., centre frequency be 433.920MHz, 915.000MHz, 2450MHz, 5800MHz, 24125MHz, 61250MHz,
The electromagnetic wave of 122500MHz or 245000MHz wave band.Wherein, it can produce built in the small portable of 2450MHz wave band electromagnetic wave forever
Long magnetite type magnetron is cheap, easily starts with, more commonly used.The electromagnetic wave of ISM band may penetrate under body surface several centimeters-number
Ten centimetres of depth is suitble to the treatment of superficial tumor.
Tumour cell used in the present invention is not particularly limited, it is proposed that uses the maligna tumour (black of body surface
Plain tumor) cell.Melanoma easily occurs in the positions such as skin, eye socket inner tissue, oral mucous epithelia.Culture medium can be used thin
General instruments used in born of the same parents' culture, is not particularly limited.The tumour cell clump count of inoculation is preferably 100 or so.Culture
2ML or 4ML can be used in base capacity, is not particularly limited.
Intermittent irradiation or Continuous irradiation can be used in electromagnetic wave, it is contemplated that the difficulty that temperature is adjusted recommends intermittent irradiation.Between
Irradiation have a rest to irradiate and stop to repeat multiple periods progress for a cycle.Irradiation time and dwell time are pressed in each period
Demand setting.For example, irradiation stopped 3 seconds after 7 seconds, this is a cycle, subsequent repetition multiple periods.Electromagnetic radiation power pushes away
Recommend 200W-10kW or 300W-1kW, preferably 400W-800W.During electromagnetic wave irradiation, electric wave interference may be generated, is had
It may influence measuring equipment.Therefore, best setting program is come within the period for stopping transmitting electromagnetic wave using measuring equipment
The data such as measuring temperature.In addition, MRI thermometry (two rivers " measuring and lure electric heating using the Non-Invasive temperature of MRI " ginseng
Examine the territory shop science and engineering department of the Chinese Academy of Sciences, university summary the 7th (2014)) and fibre optic thermometer mensuration (fertilizer after etc. " the temperature of microwave heating
The heating rate of property sort (the 2nd report) varieties of food items " referring to Japanese home economics meeting will Vol.41 No.8733-743 (1990)
Deng) it not will receive the influence of electromagnetic wave substantially, it is recommended to use.
For the tumour cell being transplanted in culture medium, a certain amount of electromagnetic wave is irradiated, for example irradiation 7 seconds stop 3 seconds being
A cycle, 1-10 period of intermittent irradiation.Recommend to place electromagnetic wave irradiation device 1 in the opposite two sides of culture medium.Later, it passes through
After crossing certain time, such as 12 hours, the quantity of surviving colonies is checked.Pass through these measurement data, it can be deduced that as shown in Figure 2
Electromagnetic wave irradiation amount and tumour cell survival rate between relationship.
It is next determined that between electromagnetic wave irradiation amount and tumour cell survival rate relationship relationship approximate function.It can be
Click single target model (SF=exp (a × Dose)), one-hit multitarget model (SF=1 (1 exp (a × Dose)) b), index letter
Exponential model (SF=a × bDose), -2 curve models of straight line (SF=exp ((a × Dose+b × Dose2))), LQ model
(SF=exp ((a × Dose+b × Dose2+c × Dose3))), RCR model (SF=exp (a × Dose)+b × Dose
× exp (c × Dose)) etc. nonlinear functions.Wherein, recommend -2 curve models of one-hit multitarget model and straight line, preferably singly
Hit more target models.
The best electromagnetic wave irradiation amount that can induce superficial tumor Apoptosis is calculated below with the function.For example,
Under one-hit multitarget model, exposure Dose needed for reaching survival rate SF can pass through formula Dose=log (1 exp (log (1
SF)/b))/a obtains.Under -2 curve models of straight line, exposure Dose needed for reaching survival rate SF can pass through Dose=
((4 × b of a2 × log (SF)) 1/2 a)/(2 × b) is calculated.
It is calculated under (culture medium 2ml) one-hit multitarget model, 2450MHz wave band electromagnetism needed for reaching 50% survival rate
The exposure of wave is about 1.5 periods.Thus it can speculate 2ml culture medium, the exposure of 2450MHz wave band electromagnetic wave was 2 periods
When, the survival rate of tumour cell is 50% or less.It is calculated under (culture medium 4ml) one-hit multitarget model, reaches 50% survival rate
The exposure of required 2450MHz wave band electromagnetic wave is about 4.5 periods, thus can speculate 4ml culture medium, 2450MHz wave band
After 5 periods of electromagnetic wave irradiation, the survival rate of tumour cell is 50% or less.Further it could be speculated that culture medium 4ML, 2450MHz
The survival rate of tumour cell after 9 periods of wave band electromagnetic wave irradiation is a few percent.It can thus be seen that culture medium capacity is (big
It is small) and the size of tumour between have correlation.It is proposed that covering the culture of implanted tumor cells in approximate function
The culture medium of relationship, tumour cell survival rate and implanted tumor cells between the size of base and the size of superficial tumor cell
Size between relationship and/or tumour cell survival rate and the size of superficial tumor cell between relationship.It is swollen to measure body surface
The size of tumor using the relationship approximate function between above-mentioned electromagnetic wave irradiation amount and tumour cell survival rate and has been transplanted swollen
Relationship, tumour cell survival rate and transplantation tumor between the size of the culture medium of oncocyte and the size of superficial tumor cell
The relationship between relationship and/or tumour cell survival rate and the size of superficial tumor cell between the culture medium size of cell is close
Being calculated like function can be with the best electromagnetic wave irradiation amount of induced tumor Apoptosis.
For 4ml culture medium, after implementing the intermittent irradiation that irradiation stops 3 seconds for 7 seconds, under 5 period exposures, culture medium
Temperature be 33.8 DEG C, under the exposure in 9 periods, the temperature of culture medium is 43.3 DEG C.In approximation to function relationship of the invention,
It is recommended that comprising between the relationship and/or tumour cell survival rate and culture medium temperature between electromagnetic wave irradiation amount and culture medium temperature
Relationship.Excessively heat (such as: heating causes cell temperature to be more than 60 DEG C) can be because acute thermal damage leads to meronecrosis.Cause
This is needed to prevent acute thermal damage according to the approximate letter of relationship between aforementioned electromagnetic wave exposure and tumour cell survival rate
The pass between relationship and/or tumour cell survival rate and culture medium temperature between number, electromagnetic wave irradiation amount and culture medium temperature
It is approximate function and if it is desired, the pass of the size of the size of the culture medium of implanted tumor cells and superficial tumor cell
System, tumour cell survival rate and the relationship between the size of implanted tumor cells culture medium and/or tumour cell survival rate with
Optimum dosage of irradiation is calculated in relationship approximate function between the size of superficial tumor cell.
As shown in fig. 6, the relation schematic diagram between the temperature change and cancer cell killing of culture medium.
Adjusting for exposure can be by the output of change electromagnetic wave, irradiation time and dwell time, more in 1 period of change
Change the modes such as periodicity to realize.
By the left hind of 106 (3ul) maligna tumor cell transplantations to mouse, breed 12 days.It 12nd day, uses
In 9 periods of electromagnetic wave (500W, 100V) intermittent irradiation of 2450MHz wave band, each period, which irradiates 7 seconds, stops 3 seconds.It calculates later
The proliferation rate of maligna tumour cell.And the proliferation rate of non-irradiated maligna tumour cell is calculated simultaneously.9 periods
The survival rate calculated according to the function of one-hit multitarget model in (culture medium 4ml) of intermittent irradiation be * * percentage irradiation
Condition.As a result as shown in Figure 4.After irradiating 9 periods, the proliferation of tumour cell can be postponed 1-2 days.Because maligna tumour is thin
The cell cycle of born of the same parents is 18-24 hours or so, if all irradiating 9 periods daily, it is possible to tumour cell can be made completely downright bad.
Meanwhile when implementing irradiation, electromagnetic wave irradiation device 1 has been placed on two side positions of mouse opposite direction.
For the directionality for improving electromagnetic wave, the directivity antennas such as parabola antenna or dipole antenna can be used.
It, can will be close according to the relationship between electromagnetic wave irradiation amount and tumour cell survival rate about the mode for determining exposure
It is fabricated to program like the method that function calculates the best electromagnetic wave irradiation amount for inducing superficial tumor Apoptosis, is installed to personal electricity
In the digital devices such as brain.Function is as mentioned before.To prevent electromagnetic wave from generating the electromagnetic interference of equipment, radiation protection is preferably selected
The digital devices such as computer.
About the adjusting method of electromagenetic wave radiation amount, as long as the input current mode of adjustable electromagnetism wave generation device is
Can, it is not particularly limited.Such as: electric device or electronic device well known to switch, electronic impedance device, thyratron etc..
Suitable irradiation position should be selected according to the position of tumour cell physically, to guarantee that electromagnetic wave can permeate
Into superficial tumor cell.
As shown in figure 5, animal 3 is placed on operating table 4 in the case where treatment object is the animals such as dog or cat 3, help
Fixed operator 2 is responsible for fixed animal 3 and provided microwaves roasting treatment instrument 1 for cancer irradiates through the invention.To prevent electricity
Magnetic wave is irradiated to operator 2, it is proposed that the gloves or operation dress of the wearing radiation proof material of operator 2.Animal 3 should also dress anti-
Operating coat, the halter etc. of material are radiated, to prevent the position other than electromagenetic wave radiation to tumour cell.Use radio (number
The tens of MHz of MHz-) heat therapy when, need to irradiate 60-90 minutes competence exertion effects.And the ISM band electromagnetic wave under the present invention
Irradiation, it is only necessary to which the extremely short time of tens of seconds-hundreds of meters can reduce the survival rate of tumour cell, not need to animal 3
Implement anesthesia.
As shown in Figure 7, Figure 8, the difference on effect of formation is treated between a variety for the treatment of means alone or in combination, the present invention provides
Device and method play apparent therapeutic effect, the thermotherapy in figure be based on the present invention be irradiated treatment
Method.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, without departing from the spirit and scope of the present invention, this hair
Bright to will also have various changes and improvements, these changes and improvements are both fallen in the scope of protection of present invention.The present invention claims
Protection scope is defined by the appending claims and its equivalent thereof.
Claims (7)
1. microwaves roasting treatment instrument for cancer, it is characterised in that: including electromagnetic wave generating device, electromagnetic wave orienting device, best electromagnetism
Wave exposure computing device and electromagnetic wave output-controlling device, the electromagnetic wave output-controlling device are filled with the electromagnetic wave
It sets and is electrically connected, electromagnetic wave generating device exports the electromagnetic wave of ISM band, and best electromagnetic wave irradiation device for calculating shines according to electromagnetic wave
The exposure for inducing superficial tumor Apoptosis is calculated in relationship approximate function between the amount of penetrating and tumour cell survival rate.
2. microwaves roasting treatment instrument for cancer according to claim 1, it is characterised in that: further include the fixed device of living body.
3. microwaves roasting treatment instrument for cancer according to claim 1, it is characterised in that: calculate the photograph for inducing epidermal cell apoptosis
The process for the amount of penetrating are as follows:
Using the culture medium after the electromagnetic wave irradiation implanted tumor cells of ISM band, electromagnetic wave irradiation amount and tumour cell are measured
Relationship between survival rate determines the relationship approximate function between electromagnetic wave irradiation amount and tumour cell survival rate, utilizes the pass
It is that approximate function calculates the best electromagnetic wave irradiation amount for inducing superficial tumor Apoptosis.
4. microwaves roasting treatment instrument for cancer according to claim 3, it is characterised in that: the relationship approximate function is based on list
Hit the function of more target models or straight line conic model.
5. microwaves roasting treatment instrument for cancer according to claim 3 or 4, it is characterised in that: irradiate the electricity of implanted tumor cells
The centre frequency of magnetic wave is 2450MHz.
6. according to the roasting treatment instrument for cancer of microwaves described in claim 3 or 4 or 5, it is characterised in that: wherein relationship approximate function packet
Include the relationship between the size of the culture medium of implanted tumor cells and superficial tumor cell size, tumour cell survival rate with
Relationship and/or tumour cell survival rate between the size of the culture medium of implanted tumor cells and the size of superficial tumor cell it
Between relationship.
7. according to the roasting treatment instrument for cancer of microwaves described in claim 3 or 4 or 5 or 6, it is characterised in that: wherein relationship approximation letter
Number includes between relationship and/or tumour cell survival rate and culture medium temperature between electromagnetic wave irradiation amount and culture medium temperature
Relationship.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4646756A (en) * | 1982-10-26 | 1987-03-03 | The University Of Aberdeen | Ultra sound hyperthermia device |
| AU2002255898A1 (en) * | 2001-03-26 | 2002-10-08 | Ellen, A., Inc. | Methods and apparatus for treating diseased tissue |
| CN107779438A (en) * | 2017-09-25 | 2018-03-09 | 杭州市第人民医院 | A kind of radiotherapy tolerance lung cancer cell line and its construction method and application |
| CN109091761A (en) * | 2018-09-21 | 2018-12-28 | 爱心科研股份公司 | Microwaves roasting treatment instrument for cancer |
-
2019
- 2019-08-05 CN CN201910715216.9A patent/CN110368591A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4646756A (en) * | 1982-10-26 | 1987-03-03 | The University Of Aberdeen | Ultra sound hyperthermia device |
| AU2002255898A1 (en) * | 2001-03-26 | 2002-10-08 | Ellen, A., Inc. | Methods and apparatus for treating diseased tissue |
| CN107779438A (en) * | 2017-09-25 | 2018-03-09 | 杭州市第人民医院 | A kind of radiotherapy tolerance lung cancer cell line and its construction method and application |
| CN109091761A (en) * | 2018-09-21 | 2018-12-28 | 爱心科研股份公司 | Microwaves roasting treatment instrument for cancer |
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