CN110357862A - The pyrazole derivatives of the segment containing quinazoline diones and its application and a kind of pesticide herbicide - Google Patents
The pyrazole derivatives of the segment containing quinazoline diones and its application and a kind of pesticide herbicide Download PDFInfo
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- CN110357862A CN110357862A CN201910290635.2A CN201910290635A CN110357862A CN 110357862 A CN110357862 A CN 110357862A CN 201910290635 A CN201910290635 A CN 201910290635A CN 110357862 A CN110357862 A CN 110357862A
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- compound
- phenyl
- alkyl
- unsubstituted
- trifluorophenyl
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- 150000003217 pyrazoles Chemical class 0.000 title claims abstract description 32
- 150000008515 quinazolinediones Chemical class 0.000 title claims abstract description 7
- 239000004009 herbicide Substances 0.000 title abstract description 19
- 230000002363 herbicidal effect Effects 0.000 title abstract description 18
- 239000000575 pesticide Substances 0.000 title abstract description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5647
- 150000001875 compounds Chemical class 0.000 claims description 1318
- -1 Phenyl Chemical group 0.000 claims description 659
- 229910052736 halogen Inorganic materials 0.000 claims description 239
- 150000002367 halogens Chemical class 0.000 claims description 235
- 125000000217 alkyl group Chemical group 0.000 claims description 184
- UFWIBTONFRDIAS-UHFFFAOYSA-N naphthalene-acid Natural products C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims description 116
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 80
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 68
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 67
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 31
- 125000001544 thienyl group Chemical group 0.000 claims description 25
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 23
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 23
- 125000002541 furyl group Chemical group 0.000 claims description 23
- 125000004076 pyridyl group Chemical group 0.000 claims description 22
- 125000004193 piperazinyl group Chemical group 0.000 claims description 17
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 17
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 16
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical class O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 16
- 125000005936 piperidyl group Chemical group 0.000 claims description 14
- 125000000335 thiazolyl group Chemical group 0.000 claims description 13
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 12
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 125000002971 oxazolyl group Chemical group 0.000 claims description 8
- 238000006467 substitution reaction Methods 0.000 claims description 8
- 125000003282 alkyl amino group Chemical group 0.000 claims description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
- 125000005605 benzo group Chemical group 0.000 claims description 4
- 150000001720 carbohydrates Chemical group 0.000 claims description 4
- 150000002790 naphthalenes Chemical class 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
- 125000004799 bromophenyl group Chemical group 0.000 claims 79
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 49
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 30
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 29
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 28
- UEMGWPRHOOEKTA-UHFFFAOYSA-N 1,3-difluorobenzene Chemical group FC1=CC=CC(F)=C1 UEMGWPRHOOEKTA-UHFFFAOYSA-N 0.000 claims 27
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 27
- 125000004361 3,4,5-trifluorophenyl group Chemical group [H]C1=C(F)C(F)=C(F)C([H])=C1* 0.000 claims 26
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 26
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims 26
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 26
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims 25
- 125000000068 chlorophenyl group Chemical group 0.000 claims 24
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 claims 15
- 150000003214 pyranose derivatives Chemical class 0.000 claims 13
- QBYJBZPUGVGKQQ-SJJAEHHWSA-N aldrin Chemical group C1[C@H]2C=C[C@@H]1[C@H]1[C@@](C3(Cl)Cl)(Cl)C(Cl)=C(Cl)[C@@]3(Cl)[C@H]12 QBYJBZPUGVGKQQ-SJJAEHHWSA-N 0.000 claims 11
- 125000001624 naphthyl group Chemical group 0.000 claims 10
- 125000004360 trifluorophenyl group Chemical group 0.000 claims 5
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 125000004188 dichlorophenyl group Chemical group 0.000 claims 3
- 125000004212 difluorophenyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 3
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- 125000001207 fluorophenyl group Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 229930192474 thiophene Natural products 0.000 claims 2
- 125000003944 tolyl group Chemical group 0.000 claims 2
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical group C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 claims 1
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical group C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 claims 1
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical group O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 1
- OZFAFGSSMRRTDW-UHFFFAOYSA-N (2,4-dichlorophenyl) benzenesulfonate Chemical group ClC1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=CC=C1 OZFAFGSSMRRTDW-UHFFFAOYSA-N 0.000 claims 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical group C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 claims 1
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical group C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 claims 1
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical group C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 claims 1
- VIJSPAIQWVPKQZ-BLECARSGSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-4,4-dimethylpentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical group NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O VIJSPAIQWVPKQZ-BLECARSGSA-N 0.000 claims 1
- ITOFPJRDSCGOSA-KZLRUDJFSA-N (2s)-2-[[(4r)-4-[(3r,5r,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-3-(1h-indol-3-yl)propanoic acid Chemical group C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H](CC[C@]13C)[C@@H]2[C@@H]3CC[C@@H]1[C@H](C)CCC(=O)N[C@H](C(O)=O)CC1=CNC2=CC=CC=C12 ITOFPJRDSCGOSA-KZLRUDJFSA-N 0.000 claims 1
- STBLNCCBQMHSRC-BATDWUPUSA-N (2s)-n-[(3s,4s)-5-acetyl-7-cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Chemical group O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)N(C(C)=O)C2=CC(C#N)=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 STBLNCCBQMHSRC-BATDWUPUSA-N 0.000 claims 1
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical group CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical group CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims 1
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical group S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 claims 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical group OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 claims 1
- MPDDTAJMJCESGV-CTUHWIOQSA-M (3r,5r)-7-[2-(4-fluorophenyl)-5-[methyl-[(1r)-1-phenylethyl]carbamoyl]-4-propan-2-ylpyrazol-3-yl]-3,5-dihydroxyheptanoate Chemical group C1([C@@H](C)N(C)C(=O)C2=NN(C(CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C2C(C)C)C=2C=CC(F)=CC=2)=CC=CC=C1 MPDDTAJMJCESGV-CTUHWIOQSA-M 0.000 claims 1
- YQOLEILXOBUDMU-KRWDZBQOSA-N (4R)-5-[(6-bromo-3-methyl-2-pyrrolidin-1-ylquinoline-4-carbonyl)amino]-4-(2-chlorophenyl)pentanoic acid Chemical group CC1=C(C2=C(C=CC(=C2)Br)N=C1N3CCCC3)C(=O)NC[C@H](CCC(=O)O)C4=CC=CC=C4Cl YQOLEILXOBUDMU-KRWDZBQOSA-N 0.000 claims 1
- OIIOPWHTJZYKIL-PMACEKPBSA-N (5S)-5-[[[5-[2-chloro-3-[2-chloro-3-[6-methoxy-5-[[[(2S)-5-oxopyrrolidin-2-yl]methylamino]methyl]pyrazin-2-yl]phenyl]phenyl]-3-methoxypyrazin-2-yl]methylamino]methyl]pyrrolidin-2-one Chemical group C1(=C(N=C(C2=C(C(C3=CC=CC(=C3Cl)C3=NC(OC)=C(N=C3)CNC[C@H]3NC(=O)CC3)=CC=C2)Cl)C=N1)OC)CNC[C@H]1NC(=O)CC1 OIIOPWHTJZYKIL-PMACEKPBSA-N 0.000 claims 1
- IOQORVDNYPOZPL-VQTJNVASSA-N (5S,6R)-5-(4-chlorophenyl)-6-cyclopropyl-3-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]-5,6-dihydro-2H-1,2,4-oxadiazine Chemical group ClC1=CC=C(C=C1)[C@@H]1NC(=NO[C@@H]1C1CC1)C1=NC(=C(C=C1)N1C=NC(=C1)C)OC IOQORVDNYPOZPL-VQTJNVASSA-N 0.000 claims 1
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 1
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 1
- SWGZHHCRMZDRSN-BTJKTKAUSA-N (Z)-but-2-enedioic acid 1-phenoxypropan-2-ylhydrazine Chemical group OC(=O)\C=C/C(O)=O.NNC(C)COC1=CC=CC=C1 SWGZHHCRMZDRSN-BTJKTKAUSA-N 0.000 claims 1
- ZYZCALPXKGUGJI-DDVDASKDSA-M (e,3r,5s)-7-[3-(4-fluorophenyl)-2-phenyl-5-propan-2-ylimidazol-4-yl]-3,5-dihydroxyhept-6-enoate Chemical group C=1C=C(F)C=CC=1N1C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C(C(C)C)N=C1C1=CC=CC=C1 ZYZCALPXKGUGJI-DDVDASKDSA-M 0.000 claims 1
- YZNQLDLXHVMJJA-UHFFFAOYSA-N 1,1-bis(4-chlorophenyl)prop-2-yn-1-ol Chemical group C=1C=C(Cl)C=CC=1C(C#C)(O)C1=CC=C(Cl)C=C1 YZNQLDLXHVMJJA-UHFFFAOYSA-N 0.000 claims 1
- FZQXMGLQANXZRP-UHFFFAOYSA-N 1-(3,4-dimethoxyphenyl)-3-(3-imidazol-1-ylpropyl)thiourea Chemical group C1=C(OC)C(OC)=CC=C1NC(=S)NCCCN1C=NC=C1 FZQXMGLQANXZRP-UHFFFAOYSA-N 0.000 claims 1
- PAEBEUZTAPIOIO-UHFFFAOYSA-N 1-(4-chlorophenyl)-3-(1-methyl-3-oxo-2-phenyl-5-propan-2-ylpyrazol-4-yl)urea Chemical group O=C1N(C=2C=CC=CC=2)N(C)C(C(C)C)=C1NC(=O)NC1=CC=C(Cl)C=C1 PAEBEUZTAPIOIO-UHFFFAOYSA-N 0.000 claims 1
- KQZLRWGGWXJPOS-NLFPWZOASA-N 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile Chemical group ClC1=C(C=CC(=C1)Cl)[C@@H](C)N1N=C(C=2C1=NC(=CN=2)C1=CC[C@@H]([C@@H](C1)C)N1[C@@H](CCC1)CO)C#N KQZLRWGGWXJPOS-NLFPWZOASA-N 0.000 claims 1
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical group CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 claims 1
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical group O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 1
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical group O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 claims 1
- KSGFJKSNZLTEDI-UHFFFAOYSA-N 1-[benzyl(methyl)amino]-3-[3-(trifluoromethyl)phenoxy]propan-2-ol Chemical group C=1C=CC=CC=1CN(C)CC(O)COC1=CC=CC(C(F)(F)F)=C1 KSGFJKSNZLTEDI-UHFFFAOYSA-N 0.000 claims 1
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- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003215 pyranoses Chemical class 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000009333 weeding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
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Abstract
The present invention relates to pesticide herbicide fields, it discloses the pyrazole derivatives of the segment containing quinazoline diones and its applies and a kind of pesticide herbicide, the pyrazole derivatives have structure shown in formula (I), and pyrazole derivatives of the invention have the advantages that broad weed-killing spectrum and high to crop safety.
Description
Technical field
The present invention relates to pesticide herbicide fields, and in particular to a kind of pyrazole derivatives of the segment containing quinazoline diones with
And a kind of application and the pesticide herbicide containing the pyrazole derivatives of the pyrazole derivatives.
Background technique
P-hydroxybenzene pyruvic acid (HPP) dioxygenase (4-HPPD) is confirmed to be herbicide action target in the last century 90's
Mark.
4-HPPD is widely present in aerobe body, is primarily involved in the metabolism of tyrosine in organism.In plant
Interior, the metabolite p-hydroxybenzene pyruvic acid (HPP) of tyrosine generates alcapton under the action of 4-HPPD, and alcapton further turns
It is melted into plastoquinone and tocopherol.Plastoquinone and tocopherol are the important as precursors of photosynthesis of plant.Therefore, by inhibiting plant
The synthesis of endoplast quinone and tocopherol hinders the normal photosynthesis of plant, cause plant occur alphosis and it is dead.
Have efficiently by the herbicide of target of 4-HPPD, low toxicity is environmentally friendly and good etc. to succession crop safety
Feature.
Therefore, 4-HPPD herbicide is a kind of very with the herbicide of researching value and development prospect, more and more
Pesticide company puts into the research and development of 4-HPPD herbicide.It is also showed in patent about the report of such herbicide in recent years
The trend of cumulative year after year.Up to the present the important target that 4-HPPD is researched and developed as new herbicides has 16 kinds of commercializations
4-HPPD class herbicide and multiple HPPD class inhibitor molecules in product development stage.
Pesticide herbicide in use, since single kind herbicide repeats to be excessively used and itself base of weeds
Because of mutation, weeds is caused serious drug resistance occur.Such as ACCase and AHAS class herbicide, it is serious due to weeds in field
Resistance problem causes such herbicide to lose control efficiency to part malignant weed increasing dosage.Cause
This, it is necessary to develop the herbicide of modulation, while avoiding the resistance problem of weeds, come solve field resistance weeds it is anti-
Control problem.
For this problem, 2015, trione compounds and its preparation method and application were declared by this seminar
(CN104557739A).On this basis, we design the 4-HPPD suppression for having synthesized a series of new by creative research again
Agent molecules, these compounds show excellent activity of weeding to numerous weeds, and show to crops good
Good safety has excellent application prospect.
Summary of the invention
The purpose of the invention is to overcome aforementioned drawback of the existing technology, providing a kind of new has broad weed-killing spectrum
With the pyrazole derivatives of the segment containing quinazoline diones of the advantage high to crop safety.
To achieve the goals above, the first aspect of the present invention provides described in claim 1 a kind of containing quinazoline diones
The pyrazole derivatives of segment.
The analog derivative provided by the invention has excellent preventive effect to weeds, while to rice, corn, wheat, cotton,
Peanut and other crops have extraordinary safety, are expected to be developed into novel HPPD class herbicide to solve current control of weeds
Problem.
In the present invention, described " saccharide residue " indicates to pass through what glycosidic bond was connect with the mother nucleus structure of formula (I) in glycan molecule
Part；Sugar in the saccharide residue of the invention can be monosaccharide, disaccharides or polysaccharide, such as can be glucose etc..
In the present invention, " alkylamino " in described " naphthalene replaced by alkylamino " is indicated by alkyl-substituted amino,
Also, the alkyl in " alkylamino " can be C1-C6Alkyl.
In the present invention, described " the substituted or unsubstituted benzo five-membered heterocycle containing at least one of N, O and S element "
It indicates benzene and five-ring heterocycles totally one chemical bond and the bicyclic compound that is formed, and at least contains N, O and S in the bicyclic compound
At least one of element.
In the present invention, described " the hexa-atomic heterocycle containing at least one of N, O and S element of substituted or unsubstituted benzo "
It indicates benzene and hexa-member heterocycle totally one chemical bond and the bicyclic compound that is formed, and at least contains N, O and S in the bicyclic compound
At least one of element.
In the present invention, " halogen " indicates first selected from least one of fluorine element, chlorine element, bromo element and iodine
Element.
In the present invention, " C1-6Alkyl " indicate, carbon atom number is the alkyl of 1-6, such as can be methyl, ethyl, just
Propyl, isopropyl, normal-butyl, isobutyl group, tert-butyl, n-pentyl, isopentyl, n-hexyl, cyclopropyl, methylcyclopropyl groups, ethyl
Cyclopropyl, cyclopenta, methylcyclopentyl, cyclohexyl.
In the present invention, " C1-6Alkoxy " indicate, it such as can be methyl oxygen that carbon atom number, which is the alkoxy of 1-6,
Base, ethyl oxygroup, n-propyl oxygroup, isopropyl oxygroup, normal-butyl oxygroup, isobutyl group oxygroup, tert-butyl oxygroup, n-pentyl oxygen
Base, isopentyl oxygroup, n-hexyl oxygroup, cyclopropyl oxygroup, methylcyclopropyl groups oxygroup, ethyl cyclopropyl oxygroup, cyclopentyloxy,
Methylcyclopentyl oxygroup, cyclohexyl oxygroup.
In the present invention, " C2-6Alkenyl " indicate, carbon atom number be 1-6 mono alkenyl, diene base or polyene-based, such as
It can be vinyl, positive acrylic, isopropenyl, n-butene base, positive dibutene base, isobutenyl, tertiary cyclobutenyl, n-pentene
Base, 1,3- pentadienyl, isopentene group, n-hexylene base, 1,3- hexadienyl, cyclopropanyl, methyl cyclopropene base, ethyl cyclopropyl
Alkenyl, cyclopentenyl, methyl cyclopentene base, cyclohexenyl group.
In the present invention, " C2-6Alkynyl " indicate, carbon atom number be 1-6 single alkynyl, double alkynyls or polyyne base, such as
It can be acetenyl, positive propinyl, isopropynyl, positive butynyl, positive two butynyl, butynyl, tertiary butynyl, positive pentyne
Base, 1,3- pentadiine base, isoamyl alkynyl, positive hexin base, 1,3- adipic alkynyl, cyclopropyl alkynyl, methyl cyclopropyl alkynyl, ethyl cyclopropyl
Alkynyl, ring pentynyl, methyl ring pentynyl, hexamethylene alkynyl.
" 0~6 integer " includes: 0,1,2,3,4,5 and 6.
Under preferable case, in formula (I), Y C1-C6Alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl
It is base, substituted or unsubstituted naphthalene, substituted or unsubstituted pyrrole radicals, substituted or unsubstituted furyl, substituted or unsubstituted
Tetrahydrofuran base, substituted or unsubstituted thienyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted imidazole radicals,
Substituted or unsubstituted pyrazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted valerolactamyl, substitution do not take
The pyridyl group in generation, substituted or unsubstituted piperidyl, substituted or unsubstituted piperazinyl, takes substituted or unsubstituted pyranose
Generation or unsubstituted pyridazinyl, substituted or unsubstituted pyrimidine radicals, substituted or unsubstituted caprolactam base.
According to the first preferred embodiment, in formula (I), X is group shown in claim 2.
According to second of preferred embodiment, in formula (I), X is group shown in claim 3.
According to the third preferred embodiment, in formula (I), X is group shown in claim 4.
According to the 4th kind of preferred embodiment, in formula (I), X is group shown in claim 5.
According to the 5th kind of preferred embodiment, in formula (I), X is group shown in claim 6.
According to the 6th kind of preferred embodiment, in formula (I), X is group shown in claim 7.
According to the 7th kind of preferred embodiment, in formula (I), X is group shown in claim 8.
According to the 8th kind of preferred embodiment, in formula (I), X is group shown in claim 9.
According to the 9th kind of preferred embodiment, in formula (I), X is group shown in claim 10.
According to the tenth kind of preferred embodiment, in formula (I), X is group shown in claim 11.
According to a kind of the tenth preferred embodiment, in formula (I), X is group shown in claim 12.
According to the 12nd kind of preferred embodiment, in formula (I), X is group shown in claim 13.
According to the 13rd kind of preferred embodiment, in formula (I), X is group shown in claim 14.
According to the 14th kind of preferred embodiment, in formula (I), X is group shown in claim 15.
According to the 15th kind of preferred embodiment, pyrazole derivatives shown in formula (I) are selected from claim 16
Shown at least one of compound.
There is no particular limitation at the methods of pyrazole derivatives shown in formula (I) for pairing of the present invention, those skilled in the art
The synthetic method in compound structure combination chemical field that member provides according to the present invention can obtain suitable preparation formula (I) institute
The method of the pyrazole derivatives shown, the present invention will not repeat them here.
The second aspect of the present invention provides application of the pyrazole derivatives in controlling weeds described in aforementioned first aspect.
The weeds include that herba setariae viridis, barnyard grass, semen euphorbiae, herba digitariae, Triticum tauschii, herba bromi japonici, wild avena sativa, amur foxtail, Japan see
Wheat ma, rye grass, rice packet grass, Cassia grass, morning glory, Siberian cocklebur, nutgrass flatsedge, common vetch, Amaranthus retroflexus, false acid pulp, Eclipta prostrata, purslane,
Pierce amaranth, beggar-ticks, Paspalum distichum, rice Leersia Sw, triquetrousc murdannia herb, angustifolia arrowhead herb, rhizoma alismatis, Monochoria korsakowii, dayflower, Monochoria vaginalis, firefly Lin, different
At least one of type nutgrass flatsedge etc..
The third aspect of the present invention provide aforementioned first aspect described in pyrazole derivatives prevention and treatment broadleaf weeds and/or
Application in gramineae weed.
In the present invention, the broadleaf weeds includes three-coloured amaranth, Chenopodium album, piemarker, rice packet grass, Cassia grass, leads a cow, is Siberian cocklebur, anti-
Branch amaranth, false acid pulp, Eclipta prostrata, purslane, thorn amaranth, triquetrousc murdannia herb, angustifolia arrowhead herb, rhizoma alismatis, Monochoria korsakowii, dayflower, Monochoria vaginalis etc. and nutgrass flatsedge:
At least one of firefly Lin, difformed galingale herb etc..
Preferably, in the present invention, the gramineae weed includes herba setariae viridis, barnyard grass, semen euphorbiae, herba digitariae, Triticum tauschii, sparrow
Wheat, wild avena sativa, amur foxtail, Alopecurus, rye grass, nutgrass flatsedge, common vetch, beggar-ticks, Paspalum distichum, in rice Leersia Sw extremely
Few one kind.
The fourth aspect of the present invention provides pyrazole derivatives answering as pesticide herbicide described in aforementioned first aspect
With.
The fifth aspect of the present invention provides a kind of pesticide herbicide, which is made of active constituent and auxiliary material,
The active constituent includes at least one of pyrazole derivatives described in aforementioned first aspect.
Pyrazole derivatives provided by the invention, which show excellent crop to corn, wheat, peanut and cotton, pacifies
Quan Xing.
Pyrazole derivatives provided by the invention have very high remove to broadleaf weeds, gramineae weed and sedge weed
Careless activity.
Specific embodiment
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
According to a kind of preferred embodiment, the present invention synthesizes pyrazoles of the invention using following route and derives
Object:
In said synthesis route, Formulas I -1, Formulas I -2, Formulas I -3, the substituent group in Formulas I -4 and pair in formula (I) of the present invention
Answer group definition identical.
In said synthesis route, in step, the synthetic method of Formulas I -2 for example can be with are as follows: is dissolved in intermediate compound I -1
In solvent, add oxalyl chloride, low temperature reaction.To end of reaction, dry solvent is taken off, remaining solid solvent dissolves spare.It is low
Under temperature, pyrazolone is dissolved in solvent, and triethylamine is added, after stirring, the solution of acid chloride dissolved with solvent is added drop-wise to reaction
In system, TLC monitoring reaction.To end of reaction, saturation NaHCO is added into reaction system3Solution, extraction merging organic layer,
Dry concentration carries out column and chromatographs to obtain intermediate compound I -2.
In said synthesis route, in stepb, the synthetic method of Formulas I -3 for example can be with are as follows: by intermediate compound I -2, acetonitrile
It is added in flask, stirs, Et is added3N and acetone cyanohydrin.TLC monitoring reaction, to after the reaction was completed, add into reaction system
Enter HCl solution, continue to stir, solid is precipitated and filters.
In said synthesis route, in step C, the synthetic method of Formulas I -4 for example can be with are as follows: by intermediate compound I -3 and molten
Agent is added in flask, is stirred and is slowly added to POCl3, temperature rising reflux.TLC monitoring reaction, to after the reaction was completed, be evaporated under reduced pressure
Solvent is removed, ether is added into remaining solid, continues to stir, solid is precipitated and filters.
It below will the present invention will be described in detail by example.In following instance, in case of no particular description,
The various raw materials used are all from commercially available.
Preparation example 1: the synthesis of compound 1-3a
Intermediate compound I -1a (5mmol) is added in the mono- neck bottle of 50mL, the dry THF of 18mL is added, slowly drips at room temperature
Add SOCl2(8mmol), 75 DEG C of back flow reactions about 1.5h after being added dropwise, TLC track reaction process, take off after reaction do it is molten
Agent.The dry CHCl of 20mL is added3, 1,3- dimethyl -5- pyrazolone (6mmol), Et3N (10mmol) reacts about 0.5h, TLC
Track to acyl chlorides disappearance.It is washed once with 20mL, is washed 2 times with the HCl of 1 mol/L of 10mL every time after completion of the reaction, used every time
The saturation NaHCO of 10mL32 times are washed, anhydrous Na2SO4It is dry, it crosses column and obtains intermediate compound I -2b.
Intermediate compound I -2b (1mmol) is added in two neck bottle of 50mL, 28mL anhydrous acetonitrile, N is added2Protection is lower to be added
Et3N (2mmol), acetone cyanohydrin (0.1mmol).8h is reacted at room temperature, and TLC tracks to reaction raw materials disappearance.It takes off after completion of the reaction
The CHCl of about 30mL is added in dry acetonitrile3With the salt pickling of 1 mol/L of 30mL, liquid separation, organic phase saturated sodium chloride solution
It washes 3 times, organic layer is dry with anhydrous sodium sulfate.Solvent give light yellow oil, gained grease 10mL methanol are sloughed in decompression
Recrystallization, obtains compound 1-3a.
Preparation example 2: the synthesis of compound 8
At 0 DEG C, compound I-3a (1.5mmol) is dissolved in anhydrous methylene chloride, is added triethylamine (3mmol), stirs
Cyclopropyl carbonyl chloride (2mmol) is added into reaction system again after mixing dissolution, continues to stir 3-6h.When after the reaction was completed, to anti-
It answers and is slowly added to saturated sodium bicarbonate solution (15ml) in system, reaction solution is extracted with dichloromethane, organic phase is eaten with saturation
Salt water washes twice.Anhydrous sodium sulfate dries organic phase, and vacuum distillation removing solvent obtains crude product, then passes through column chromatography point
From purification.
Preparation example 3: the synthesis of compound 46
At 0 DEG C, intermediate compound I -3a (1mmol) is dissolved in super dry DCM, Et is added3N (1.5mmol) is stirred afterwards
2- thiophenesulfonyl chloride (1.5mmol) solution is slowly added dropwise in 15min into reaction system, continues extensive after stirring 30min at 0 DEG C
3h is reacted at room temperature again.When after the reaction was completed, into reaction system, addition saturated sodium bicarbonate solution (15ml) liquid separation is collected organic
Phase, organic phase are washed twice with saturated salt solution.Organic phase is dry with anhydrous sodium sulfate, and vacuum distillation removing solvent obtains slightly
Then product is purified by column chromatography for separation.
Preparation example 4: the synthesis of compound 100
At 0 DEG C, intermediate compound I -3b (1mmol) is dissolved in super dry DCM, triethylamine (1.5mmol) is added and stirs afterwards
15min, is slowly added dropwise N into reaction system, and N- diallyl formyl chloride (1.5mmol) continues after stirring 30min at 0 DEG C
Restore room temperature reaction 3h.Have when saturated sodium bicarbonate solution (15ml) liquid separation collection after the reaction was completed, is added into reaction system
Machine phase, organic phase are washed twice with saturated salt solution.Organic phase is dry with sodium sulphate, and vacuum distillation removing solvent is slightly produced
Then product are purified by column chromatography for separation.
The derivative of the segment of the invention containing quinazoline diones has been synthesized according to the method described above.
The structural characterization data of part of compounds of the invention are listed in following table 1.
Table 1
Test case 1: activity of weeding testing experiment (phjytotron)
Primary Screening Test (pot-culture method): internal diameter 6cm flowerpot, dress composite earth (vegetable garden soil: seedling medium, 1:2, v/v) to 3/4 are taken
Place, directly weeds target (bud rate >=85%) described in sowing table 2, earthing 0.2cm are spare to or so the 3 leaf phases to weeds length.Respectively
Compound is according to dosage shown in table 2 after the application of auto spraying tower, and after crop blade face, medical fluid moves into hot-house culture after drying
(25 DEG C -28 DEG C, humidity 70%), investigation result after 30 days, the results are shown in Table 2.
Investigation method: target victim symptom and growth inhibition situation are estimated after test process 30 days, and claims aerial part fresh
Weight calculates fresh weight inhibition rate (%), indicates preventive effect (%) with fresh weight inhibition rate.
Fresh weight inhibition rate (%)=(control fresh weight-processing fresh weight)/control fresh weight × 100
Activity of weeding evaluation (drug resistance, slight inhibitions, slight albefaction, mild malformation, severe deformities, complete albefaction, completely extremely
The symptoms such as die):
G grades-with control, drug resistance, preventive effect is less than 10%；
F grades-growth slightly influences, slight to inhibit, poor activity, and preventive effect is 10% to less than 20%；
E grades-growth has an impact, slight albefaction, poor activity, and preventive effect is 20% to less than 50%；
D grades-growth has an impact, mild malformation, and activity is medium, and preventive effect is 50% to less than 70%；
C grades-more sensitive, severe deformities, preferably, preventive effect is 70% to less than 90% to activity；
B grades-extremely sensitive, complete albefaction, activity is good, and into sieve, preventive effect is 90% to less than 100%；
A grades-completely dead, active good, preventive effect 100%.
Table 2
The results show that the activity of weeding inhibiting rate (%) of the derivative of the segment of the invention containing quinazoline diones is higher
(most compounds of the invention are more than 50% to the control efficiency of the target weeds of test, and the most of chemical combination tested
Object is better than gramineae weed to the control efficiency of broadleaf weeds), there is excellent control efficiency to the weeds tested.
Meanwhile the activity of weeding that the compound of test is also excellent in the weeds of wheat paddock.
Test case 2: removing activity spectrum test
Removing activity spectrum test (cauline leaf spraying treatment after seedling): choosing common weed is test target.Take internal diameter 7.5cm flower
Basin, dress composite earth (vegetable garden soil: seedling medium, 1:2, v/v) directly sow target weed seed (bud described in table 3 at 3/4
Rate >=85%), earthing, and water is added to keep ground moistening, and it is long to the 3-4 leaf phase to weeds, it is spare.Each compound is shown in table
Dosage moves into hot-house culture, estimates investigation result after 30 days, the results are shown in Table 3 after the application of auto spraying tower.
Investigation method and activity of weeding evaluation method are identical with test case 1.
Table 3: the primary dcreening operation activity of weeding test result of part of compounds
" -- " indicates not test
The results show that the derivative of the segment of the invention containing quinazoline diones, has the advantages that degrass spectrum is extensive, with commodity
Chemical drug agent mesotrione is suitable, and therefore, the compound of the present invention has extraordinary application prospect.
Test case 3: crop safety measurement
Crop safety measurement (cauline leaf spraying treatment after seedling): as shown in table 4 for studying object target.Take internal diameter 9.0cm
Flowerpot, dress composite earth (vegetable garden soil: seedling medium, 1:2, v/v) directly sow crop target seed described in table 4 at 3/4
(bud rate >=85%), earthing, and water is added to keep ground moistening, and it is long to the 3-5 leaf phase to crop target, it is spare.Each compound according to
Dosage shown in table 4 moves into hot-house culture, investigation result after 30 days after auto spraying tower (model: 3WPSH-700E) application.
Investigation method and activity of weeding evaluation method are identical with test case 1.
Table 4: part of compounds primary dcreening operation crop safety experimental result
" -- " indicates not test
The results show that the derivative of the segment of the invention containing quinazoline diones has preferable crop-selective, it is right respectively
Corn, wheat, peanut and cotton show preferable crop safety, with important application prospects.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (16)
1. a kind of pyrazole derivatives of segment containing quinazoline diones, which has structure shown in formula (I),
Wherein, in formula (I),
R1Selected from H, substituted or unsubstituted phenyl, substituted or unsubstituted C1-C6Alkyl；
R2Selected from H, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substituted or unsubstituted C1-C6Alkyl；
R3Selected from H, C1-C6Alkyl, C1-C6Alkenyl, C1-C6Alkynyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl；
R4For H or methyl；
Z is O or S；
Y is C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substitution
Or unsubstituted naphthalene, substituted or unsubstituted indenyl, it is substituted or unsubstituted five yuan containing at least one of N, O and S element
Heterocycle, the substituted or unsubstituted hexa-atomic heterocycle containing at least one of N, O and S element, substituted or unsubstituted benzo five
Heterocycle, substituted or unsubstituted benzo of the member containing at least one of N, O and S element are hexa-atomic first containing at least one of N, O and S
The heterocycle of element；
And R1、R2、R3Halogen, C are each independently selected from the substituent group being optionally present in Y1-C6Alkyl, C1-C6Alkoxy, by
The C that halogen replaces1-C6Alkyl, the C replaced by halogen1-C6Alkoxy, phenoxy group, nitro and amino；
X is any group in following X1-X14 or X is the saccharide residue of protection or deprotection, and the guarantor in saccharide residue
It protects base and is selected from acetyl group, formoxyl, propiono, bytyry, unsubstituted or by C1-C6The benzoyl that alkyl and/or halogen replace
With it is unsubstituted or by C1-C6At least one of the benzyl formoxyl that alkyl and/or halogen replace:
Wherein, in X1-X14, A1、A2a、A2b、A3、A4、A5、A6a、A6b、A7、A8、A9a、A9b、A10a、A10b、A11a、A11b、A12a、
A12b、A13a、A13b、A14aAnd A14bIt is each independently selected from H, C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, by halogen replace
C1-C12Alkyl, C1-C12Alkoxy, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, naphthalene, by alkylamino replace naphthalene, pyridyl group, furyl, thienyl, by C1-C6The thiophene that alkyl and/or halogen replace
Pheno base, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals, by C1-C6Alkyl-substituted imidazole radicals, by C1-C6Alkyl
Substituted amino；
And the n in X1-X14 is each independently 0~6 integer；
Preferably,
In formula (I),
Y is C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, substitution
Or unsubstituted naphthalene, substituted or unsubstituted pyrrole radicals, substituted or unsubstituted furyl, substituted or unsubstituted tetrahydro furan
It mutters base, substituted or unsubstituted thienyl, substituted or unsubstituted thiazolyl, substituted or unsubstituted imidazole radicals, substitution or not
Substituted pyrazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted valerolactamyl, substituted or unsubstituted pyridine
Base, substituted or unsubstituted pyranose, substituted or unsubstituted piperidyl, substituted or unsubstituted piperazinyl, substitution do not take
The pyridazinyl in generation, substituted or unsubstituted pyrimidine radicals, substituted or unsubstituted caprolactam base.
2. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X1,
In X1, A1Selected from C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, by C1-C6Phenyl that alkyl and/or halogen replace, not
Replace or by C1-C6It is benzyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Naphthalene that alkyl and/or halogen replace, not
Replace or by C1-C6It is pyrrole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6The furans that alkyl and/or halogen replace
It is base, unsubstituted or by C1-C6It is tetrahydrofuran base that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the thienyl in generation, unsubstituted or by C1-C6It is thiazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is imidazole radicals that element replaces, unsubstituted or by C1-C6It is pyrazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/
Or the oxazolyl, unsubstituted or by C that halogen replaces1-C6It is valerolactamyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is pyridyl group that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyranose that alkyl and/or halogen replace, it is unsubstituted or
By C1-C6It is piperidyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or the piperazinyl of halogen substitution do not take
Generation or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrimidine radicals that alkyl and/or halogen replace,
It is unsubstituted or by C1-C6The caprolactam base that alkyl and/or halogen replace；Preferably,
In X1, A1Selected from C1-C12Alkyl, by C1-C6The phenyl that alkyl and/or halogen replace；Preferably,
In X1, A1Selected from C1-C8Alkyl, by C1-C6Alkyl-substituted phenyl.
3. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X2,
In X2, A2aAnd A2bIt is each independently selected from H, C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-
C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6Alkoxy replace phenyl, it is unsubstituted or by
C1-C6It is benzyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Naphthalene that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is pyrrole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6It is furyl that alkyl and/or halogen replace, unsubstituted
Or by C1-C6It is tetrahydrofuran base that alkyl and/or halogen replace, unsubstituted or by C1-C6The thiophene that alkyl and/or halogen replace
It is base, unsubstituted or by C1-C6It is thiazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is imidazole radicals, unsubstituted or by C1-C6It is pyrazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the oxazolyl in generation, unsubstituted or by C1-C6It is valerolactamyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/
Or the pyridyl group, unsubstituted or by C that halogen replaces1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkane
It is piperidyl that base and/or halogen replace, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrimidine radicals that alkyl and/or halogen replace, it is unsubstituted or
By C1-C6The caprolactam base that alkyl and/or halogen replace；Preferably,
In X2, A2aAnd A2bIt is each independently selected from H, C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6
Phenyl that alkyl and/or halogen replace, by C1-C6The phenyl that alkoxy replaces；Preferably,
In X2, A2aAnd A2bIt is each independently selected from H, C1-C12Alkyl, by C1-C6Alkyl-substituted phenyl, and A2aAnd A2bIt is different
When be H.
4. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X3,
In X3, A3Selected from H, C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12It is alkylthio group, phenyl, unsubstituted or by C1-
C6The C of benzyl, halogen substitution that alkyl and/or halogen replace1-C12It is alkylthio group, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the naphthalene in generation, unsubstituted or by C1-C6It is pyrrole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted furyl, unsubstituted or by C1-C6It is tetrahydrofuran base that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl
And/or the thienyl, unsubstituted or by C that halogen replaces1-C6It is thiazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6
It is imidazole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrazolyl that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is oxazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Valerolactamyl that alkyl and/or halogen replace, not
Replace or by C1-C6It is pyridyl group that alkyl and/or halogen replace, unsubstituted or by C1-C6The pyrans that alkyl and/or halogen replace
It is base, unsubstituted or by C1-C6It is piperidyl that alkyl and/or halogen replace, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is piperazinyl, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the pyrimidine radicals in generation, unsubstituted or by C1-C6The caprolactam base that alkyl and/or halogen replace；Preferably,
In X3, A3Selected from H, C1-C12Alkyl, phenyl, C1-C12The C that alkylthio group, halogen replace1-C12Alkylthio group；Preferably,
In X3, A3Selected from H, C1-C10Alkyl, C1-C12The C that alkylthio group, halogen replace1-C12Alkylthio group.
5. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X4,
In X4, A4Selected from C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-
C6It is phenyl that alkyl and/or halogen replace, unsubstituted or by C1-C6It is benzyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is naphthalene that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrrole radicals that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is furyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Tetrahydrofuran base that alkyl and/or halogen replace, not
Replace or by C1-C6It is thienyl that alkyl and/or halogen replace, unsubstituted or by C1-C6The thiazole that alkyl and/or halogen replace
It is base, unsubstituted or by C1-C6It is imidazole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is pyrazolyl, unsubstituted or by C1-C6It is oxazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the valerolactamyl in generation, unsubstituted or by C1-C6It is pyridyl group that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/
Or the pyranose, unsubstituted or by C that halogen replaces1-C6It is piperidyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkane
It is piperazinyl that base and/or halogen replace, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6The caprolactam base that alkyl and/or halogen replace；It is preferred that
Ground,
In X4, A4Selected from C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Alkyl and/or halogen replace
Phenyl；Preferably,
In X4, A4Selected from C1-C10Alkyl, by C1-C6Alkyl-substituted phenyl.
6. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X5,
In X5, A5Selected from C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-
C6It is phenyl that alkyl and/or halogen replace, unsubstituted or by C1-C6It is benzyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is naphthalene that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrrole radicals that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is furyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Tetrahydrofuran base that alkyl and/or halogen replace, not
Replace or by C1-C6It is thienyl that alkyl and/or halogen replace, unsubstituted or by C1-C6The thiazole that alkyl and/or halogen replace
It is base, unsubstituted or by C1-C6It is imidazole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is pyrazolyl, unsubstituted or by C1-C6It is oxazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen take
It is the valerolactamyl in generation, unsubstituted or by C1-C6It is pyridyl group that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/
Or the pyranose, unsubstituted or by C that halogen replaces1-C6It is piperidyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkane
It is piperazinyl that base and/or halogen replace, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6The caprolactam base that alkyl and/or halogen replace；It is preferred that
Ground,
In X5, A5Selected from C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Alkyl and/or halogen replace
Phenyl；Preferably,
In X5, A5Selected from C1-C10Alkyl, by C1-C6Alkyl-substituted phenyl.
7. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X6,
In X6, A6aAnd A6bIt is each independently selected from C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-C12
It is alkyl, phenyl, unsubstituted or by C1-C6It is benzyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted naphthalene, unsubstituted or by C1-C6It is pyrrole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is furyl that element replaces, unsubstituted or by C1-C6It is tetrahydrofuran base that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkane
It is thienyl that base and/or halogen replace, unsubstituted or by C1-C6It is thiazolyl that alkyl and/or halogen replace, unsubstituted or by C1-
C6It is imidazole radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Pyrazolyl that alkyl and/or halogen replace, it is unsubstituted or
By C1-C6It is oxazolyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Valerolactamyl that alkyl and/or halogen replace,
It is unsubstituted or by C1-C6It is pyridyl group that alkyl and/or halogen replace, unsubstituted or by C1-C6The pyrrole that alkyl and/or halogen replace
It mutters base, unsubstituted or by C1-C6It is piperidyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperazinyl, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyrimidine radicals, unsubstituted or by C1-C6The caprolactam base that alkyl and/or halogen replace；Preferably,
In X6, A6aAnd A6bIt is each independently selected from C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Alkane
Phenyl, the pyridyl group, furyl, thienyl that base and/or halogen replace；Preferably,
In X6, A6aAnd A6bIt is each independently selected from C1-C8Alkyl, by C1-C6Phenyl, the pyridine that alkyl and/or halogen replace
Base.
8. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X7,
In X7, A7Selected from C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy, the C replaced by halogen1-C12Alkane
Base, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6Alkoxy replace phenyl, pyridyl group, furyl,
Thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals,
By C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6It is naphthalene that alkyl and/or halogen replace, unsubstituted or by C1-C6
It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Piperidyl that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted
Or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6The thiazolyl that alkyl and/or halogen replace, or
Person A7For group shown in X15, and the integer that n is 0~6,
And in X15, A15aAnd A15bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy,
The C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, pyridyl group, furyl, thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl
Substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is naphthalene, unsubstituted or by C1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperidyl, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyridazinyl, unsubstituted or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or
Halogen replace thiazolyl, benzyl, by C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X7, A7Selected from C1-C12Alkyl, C1-C12Alkoxy, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Alkyl
And/or halogen replace phenyl, by C1-C6Alkoxy replace phenyl, pyridyl group, furyl, thienyl, by C1-C6Alkyl
And/or halogen replace thienyl, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted
Imidazole radicals or A7For group shown in X15, and the integer that n is 0~3,
And in X15, A15aAnd A15bIt is each independently C1-C8Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, by halogen replace
C1-C8Alkyl, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6The benzyl that alkyl and/or halogen replace
Base；Preferably,
In X7, A7Selected from C1-C8Alkyl, C1-C8Alkoxy, the C replaced by halogen1-C8Alkyl, phenyl, by C1-C6Alkyl and/
Or halogen replace phenyl, by C1-C6Alkoxy replace phenyl, pyridyl group, furyl, thienyl, by C1-C6Alkyl and/or
Halogen replace thienyl, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals, by C1-C6Alkyl-substituted imidazoles
Base or A7For group shown in X15, and the integer that n is 0~2,
And in X15, A15aAnd A15bIt is each independently C1-C8Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, by halogen replace
C1-C8Alkyl, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6The benzyl that alkyl and/or halogen replace
Base.
9. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X8,
In X8, A8Selected from C1-C6Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, phenyl, by C1-C6The benzene that alkyl and/or halogen replace
Base, pyridyl group, furyl, thienyl, naphthalene, pyranose, piperidyl, piperazinyl, pyridazinyl, pyrimidine radicals, thiazolyl, by halogen
Substituted C1-C12Alkyl, C1-C12Alkoxy, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals, furyl, thienyl, pyrroles
Base, by C1-C6Alkyl-substituted imidazole radicals, the naphthalene or A replaced by alkylamino8For group shown in X16；
And in X16, A16aAnd A16bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy,
The C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, pyridyl group, furyl, thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl
Substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is naphthalene, unsubstituted or by C1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperidyl, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyridazinyl, unsubstituted or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or
Halogen replace thiazolyl, benzyl, by C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X8, A8Selected from phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, pyridyl group, furyl, thienyl, by halogen
The C that element replaces1-C12Alkyl, C1-C12Alkoxy, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted
Imidazole radicals, the naphthalene or A replaced by alkylamino8For group shown in X16；
And in X16, A16aAnd A16bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy,
The C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, pyridyl group, furyl, thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl
Substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is naphthalene, unsubstituted or by C1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperidyl, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyridazinyl, unsubstituted or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or
Halogen replace thiazolyl, benzyl, by C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X8, A8Selected from phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, pyridyl group, furyl, thienyl, by C1-
C6Alkyl-substituted pyrazolyl, by C1-C6Alkyl-substituted imidazole radicals, the C replaced by halogen1-C8Alkyl, C1-C8Alkoxy, by
The naphthalene of dimethylamino substitution, the naphthalene or A replaced by lignocaine8For group shown in X16,
And in X16, A16aAnd A16bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy,
The C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, pyridyl group, furyl, thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl
Substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is naphthalene, unsubstituted or by C1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperidyl, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyridazinyl, unsubstituted or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or
Halogen replace thiazolyl, benzyl, by C1-C6The benzyl that alkyl and/or halogen replace.
10. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X9,
In X9, A9aAnd A9bIt is each independently selected from C1-C12Alkoxy, C1-C6Phenyl, the benzyl that alkyl and/or halogen replace,
Or A9a、A9bIt is each independently group shown in X17；
And in X17, A17aAnd A17bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy,
The C replaced by halogen1-C12Alkyl, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkoxy replaced
Phenyl, pyridyl group, furyl, thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl
Substituted pyrazolyl, imidazole radicals, by C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6What alkyl and/or halogen replaced
It is naphthalene, unsubstituted or by C1-C6It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen replace
Piperidyl, unsubstituted or by C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or halogen
It is substituted pyridazinyl, unsubstituted or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Alkyl and/or
Halogen replace thiazolyl, benzyl, by C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X9, A9aAnd A9bIt is each independently selected from C1-C12Alkoxy or A9a、A9bFor group shown in X17,
And in X17, A17aAnd A17bIt is each independently C1-C12Alkyl, C1-C12Alkoxy, the C replaced by halogen1-C12Alkane
Base, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6Alkoxy replace phenyl, pyridyl group, furyl,
Thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals,
By C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6It is naphthalene that alkyl and/or halogen replace, unsubstituted or by C1-C6
It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Piperidyl that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted
Or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Thiazolyl, the benzyl that alkyl and/or halogen replace
Base, by C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X9, A9aAnd A9bIt is each independently selected from C1-C8Alkoxy or A9a、A9bFor group shown in X17,
And in X17, A17aAnd A17bIt is each independently C1-C12Alkyl, C1-C12Alkoxy, the C replaced by halogen1-C12Alkane
Base, phenyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6Alkoxy replace phenyl, pyridyl group, furyl,
Thienyl, by C1-C6Thienyl that alkyl and/or halogen replace, pyrazolyl, by C1-C6Alkyl-substituted pyrazolyl, imidazole radicals,
By C1-C6It is alkyl-substituted imidazole radicals, unsubstituted or by C1-C6It is naphthalene that alkyl and/or halogen replace, unsubstituted or by C1-C6
It is pyranose that alkyl and/or halogen replace, unsubstituted or by C1-C6Piperidyl that alkyl and/or halogen replace, it is unsubstituted or by
C1-C6It is piperazinyl that alkyl and/or halogen replace, unsubstituted or by C1-C6It is pyridazinyl that alkyl and/or halogen replace, unsubstituted
Or by C1-C6It is pyrimidine radicals that alkyl and/or halogen replace, unsubstituted or by C1-C6Thiazolyl, the benzyl that alkyl and/or halogen replace
Base, by C1-C6The benzyl that alkyl and/or halogen replace.
11. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X10,
In X10, A10aAnd A10bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, C1-C12Alkoxy, phenyl,
Benzyl, the C replaced by C1-C6 alkyl and/or halogen1-C12Alkyl, the phenyl replaced by C1-C6 alkyl and/or halogen and by
The benzyl that C1-C6 alkyl and/or halogen replace；Preferably,
In X10, A10aAnd A10bIt is each independently C1-C12Alkyl, the C replaced by halogen1-C12Alkyl；Preferably,
In X10, A10aAnd A10bIt is each independently C1-C6Alkyl.
12. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X11,
In X11, A11aAnd A11bIt is each independently H, C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-
C12Alkyl, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6The benzyl that alkyl and/or halogen replace
Base, and the integer that n is 0~6；Preferably,
In X11, A11aAnd A11bIt is each independently H, C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-C6
The phenyl that alkyl and/or halogen replace, and the integer that n is 0~2；Preferably,
In X11, A11aAnd A11bIt is each independently H, C1-C6Alkyl, phenyl, and A11aAnd A11bBe not simultaneously H and n be 0
Or 1.
13. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X12,
In X12, A12aAnd A12bBe each independently H, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by
C1-C6The benzyl that alkyl and/or halogen replace；Preferably,
In X12, A12aAnd A12bIt is each independently H, phenyl, by C1-C6The phenyl that alkyl and/or halogen replace；Preferably,
In X12, A12aAnd A12bIt is each independently H, phenyl, by C1-C4Alkyl-substituted phenyl, and A12aAnd A12bWhen different
For H.
14. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X13,
In X13, A13aAnd A13bIt is each independently selected from H, C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, by halogen replace
C1-C12Alkyl, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6What alkyl and/or halogen replaced
Benzyl, and the integer that n is 0~6；Preferably,
In X13, A13aAnd A13bIt is each independently selected from H, C1-C12Alkyl, the C replaced by halogen1-C12Alkyl, phenyl, by C1-
C6The phenyl that alkyl and/or halogen replace, and the integer that n is 0~3；Preferably,
In X13, A13aAnd A13bIt is each independently selected from H, C1-C8Alkyl, phenyl, by C1-C6The benzene that alkyl and/or halogen replace
Base, and A13aAnd A13bIt is not simultaneously the integer that H and n is 0~2.
15. pyrazole derivatives according to claim 1, wherein in formula (I), X is group shown in following X14,
In X14, A14aAnd A14bIt is each independently C1-C12Alkyl, C2-C6Alkenyl, C2-C6Alkynyl, the C replaced by halogen1-C12
Alkyl, phenyl, benzyl, by C1-C6Phenyl that alkyl and/or halogen replace, by C1-C6The benzyl that alkyl and/or halogen replace,
And the integer that n is 0~6；Preferably,
In X14, A14aAnd A14bIt is each independently C1-C12Alkyl, and the integer that n is 0~2；Preferably,
In X14, A14aAnd A14bIt is each independently C1-C8Alkyl, and n is 0 or 1.
16. pyrazole derivatives according to claim 1, wherein pyrazole derivatives shown in formula (I) are selected from followingization
Close at least one of object:
Compound 1:R1ForR2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 2:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is-OCH3；
Compound 3:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is-OC2H5；
Compound 4:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is n-OC3H7；
Compound 5:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 6:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 7:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 8:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 9:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 10:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 11:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 12:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 13:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 14:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 15:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 16:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 17:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 18:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 19:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 20:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 21:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 22:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 23:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 24:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 25:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 26:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 27:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 28:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 29:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 30:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 31:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 32:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 33:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 34:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 35:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 36:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 37:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 38:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 39:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 40:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 41:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 42:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 43:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 44:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 45:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 46:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 47:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 48:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 49:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 50:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 51:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 52:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 53:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 54:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 55:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 56:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is
Compound 95:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 96:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 97:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 98:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 99:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 100:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 101:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 102:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 103:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 104:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 105:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 106:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 107:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 108:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 109:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 110:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 111:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 112:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 113:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 114:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 115:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 116:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 117:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 118: R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 119:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 120:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 121:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is
Compound 122:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 123:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 124:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 125:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 126:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 127:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 128:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 129:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 130:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 131:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 132:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 133:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 134:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 135:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 136:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 137:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 138:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 139:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 140:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 141:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 142:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 143:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 144:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 145:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 146:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 147:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 148:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is
Compound 149:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 156:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 157:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 158:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 159:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 160:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 161:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 162:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 163:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 164:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 165:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 166:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 167:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 168:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 167:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 170:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 171:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 172:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 173:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 174:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 175:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 176:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 177:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 178:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 179:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is
Compound 180:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 181:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 182:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 183:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 184:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 185:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 186:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 187:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 188:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 189:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 190:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 191:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 192:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 193:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 194:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 195:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 196:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 197:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 198:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 199:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 200:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 201:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 202:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 203:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 204:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 205:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 206:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dichloro-phenyl；X is
Compound 207:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 208:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 209:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 210:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 211:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 212:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 213:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 214:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 215:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 216:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 217:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 218:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 219:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 220:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 221:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 222:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 223:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 224:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 225:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 226:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 227:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 228:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 229:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 230:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 231:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 232:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 233:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dichloro-phenyl；X is
Compound 234:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 235:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 236:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 237:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 238:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 239:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 240:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 241:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 242:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 243:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 244:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 245:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 246:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 247:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 248:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 249:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 250:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 251:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 252:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 253:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 254:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 255:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 256:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 257:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 258:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 259:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 260:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is
Compound 261:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 262:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 263:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 264:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 265:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 266:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 267:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 268:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 269:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 270:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 271:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 272:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 273:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 274:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 275:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 276:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 277:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 278:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 279:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 280:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 281:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 282:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 283:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 284:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 285:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 286:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 287:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trichloro-phenies；X is
Compound 288:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 289:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 290:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 291:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 292:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 293:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 294:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 295:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 296:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 297:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 298:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 299:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 300:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 301:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 302:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 303:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 304:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 305:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 306:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 307:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 308:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 309:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 310:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 311:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 312:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 313:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 314:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trichloro-pheny；X is
Compound 315:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 316:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 317:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 318:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 319:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 320:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 321:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 322:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 323:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 324:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 325:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 326:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 327:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 328:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 329:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 330:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 331:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 332:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 333:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 334:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 335:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 336:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 337:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 338:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 339:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 340:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 341:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trichloro-pheny；X is
Compound 342:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 343:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 344:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 345:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 346:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 347:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 348:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 349:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 350:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 351:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 352:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 353:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 354:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 355:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 356:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 357:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 358:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 359:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 360:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 361:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 362:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 363:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 364:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 365:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 366:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 367:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 368:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trichloro-pheny；X is
Compound 369:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 370:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 371:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 372:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 373:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 374:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 375:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 376:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 377:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 378:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 379:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 380:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 381:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 382:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 383:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 384:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 385:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 386:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 390:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 391:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 392:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 393:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 394:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 395:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 396:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,6- trichloro-pheny；X is
Compound 397:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 398:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 399:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 400:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 401:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 402:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 403:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 404:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 405:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 406:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 407:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 408:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 409:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 410:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 411:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 412:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 413:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 414:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 415:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 416:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 417:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 418:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 419:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 420:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 421:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 422:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 423:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5- tetra- chloro- phenyl；X is
Compound 424:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 425:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 426:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 427:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 428:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 429:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 430:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 431:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 432:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 433:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 434:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 435:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 436:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 437:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 438:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 439:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 440:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 441:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 442:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 443:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 444:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 445:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 446:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 447:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 448:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 449:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 450:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,6- tetra- chloro- phenyl；X is
Compound 451:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 452:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 453:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 457:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 458:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 459:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 460:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 461:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 462:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 463:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 464:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 465:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 466:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 467:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 468:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 469:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 470:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 471:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 472:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 473:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 474:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 475:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 476:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 477:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 478:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4,5,6- five chloro- phenyl；X
For
Compound 479:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 480:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 481:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 482:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 483:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 484:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 485:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 486:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 487:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 488:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 489:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 490:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 491:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 492:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 493:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 494:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 495:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 496:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 497:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 498:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 499:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 500:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 501:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 502:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 503:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 504:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 505:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- fluorophenyl；X is
Compound 506:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 507:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 508:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 509:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 510:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 511:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 512:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 513:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 514:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 515:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 516:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 517:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 518:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 519:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 520:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 521:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 522:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 523:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 524:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 525:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 526:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 527:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 528:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 529:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 530:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 531:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 532:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- fluorophenyl；X is
Compound 533:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 534:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 535:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 536:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 537:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 538:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 539:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 540:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 541:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 542:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 543:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 544:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 545:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 546:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 547:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 548:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 549:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 550:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 551:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 552:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 553:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 554:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 555:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 556:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 557:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 558:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 559:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- fluorophenyl；X is
Compound 560:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 561:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 562:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 563:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 564:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 565:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 566:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 567:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 568:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 569:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 570:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 571:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 572:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 573:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 574:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 575:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 576:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 577:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 578:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 579:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 580:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 581:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 582:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 583:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 584:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 585:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 586:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- difluorophenyl；X is
Compound 587:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 588:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 589:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 590:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 591:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 592:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 593:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 594:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 595:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 596:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 597:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 598:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 599:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 600:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 601:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 602:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 603:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 604:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 605:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 606:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 607:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 608:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 609:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 610:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 611:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 612:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 613:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4 difluorobenzene base；X is
Compound 614:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 615:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 616:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 617:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 618:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 619:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 620:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 621:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 623:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 624:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 625:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 626:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 627:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 628:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 629:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 630:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 631:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 632:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 633:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 634:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 635:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 636:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 637:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 638:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 639:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 640:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 641:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- difluorophenyl；X is
Compound 642:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 643:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 644:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 645:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 646:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 647:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 648:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 649:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 650:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 651:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 652:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 653:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 654:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 655:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 656:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 657:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 658:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 659:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 660:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 661:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 662:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 663:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 664:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 665:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 667:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 668:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- difluorophenyl；X is
Compound 669:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 670:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 671:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 672:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 673:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 674:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 675:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 676:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 677:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 678:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 679:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 680:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 681:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 682:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 683:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 684:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 685:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 686:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 687:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 688:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 689:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 690:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 691:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 692:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 693:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 694:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 695:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,4- trifluorophenyl；X is
Compound 696:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 697:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 698:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 699:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 700:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 701:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 702:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 703:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 704:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 705:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 706:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 707:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 708:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 709:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 710:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 711:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 712:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 713:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 714:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 715:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 716:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 717:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 718:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 719:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 720:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 721:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 722:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,5- trifluorophenyl；X is
Compound 723:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 724:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 725:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 726:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 727:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 728:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 729:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 730:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 731:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 732:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 733:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 734:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 735:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 736:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 737:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 738:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 739:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 740:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 741:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 742:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 743:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 744:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 745:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 746:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 747:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 748:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 749:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3,6- trifluorophenyl；X is
Compound 750:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 751:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 752:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 753:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 754:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 755:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 756:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 757:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 758:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 759:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 760:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 761:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 762:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 763:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 764:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 765:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 767:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 768:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 781:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 782:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 783:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 784:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 785:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 786:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 787:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,5- trifluorophenyl；X is
Compound 788:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 789:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 790:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 791:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 792:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 793:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 794:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 795:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 796:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 797:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 798:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 799:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 800:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 801:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 802:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 803:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 804:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 805:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 806:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 807:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 808:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 809:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 810:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 811:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 812:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 813:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 814:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trifluorophenyl；X is
Compound 815:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 816:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 817:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 818:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 819:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 820:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 821:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 822:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 823:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 824:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 825:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 826:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 827:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 828:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 829:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 830:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 831:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 832:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 833:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 834:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 835:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 836:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 837:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 838:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 839:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 840:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 841:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3,4,5- trifluorophenyl；X is
Compound 843:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 844:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 845:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 846:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 847:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 848:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 850:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 851:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 852:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 853:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 854:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 855:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 856:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 857:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 858:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 859:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 860:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 861:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 862:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 863:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 864:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 865:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 866:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 867:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 868:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methylphenyl；X is
Compound 869:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 870:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 871:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 872:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 873:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 874:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 875:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 876:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 877:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 878:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 879:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 880:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 881:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 882:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 883:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 884:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 885:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 886:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 887:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 888:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 889:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 900:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 901:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 902:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 903:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 904:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 905:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- methylphenyl；X is
Compound 906:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 907:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 908:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 909:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 910:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 911:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 912:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 913:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 914:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 915:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 916:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 917:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 918:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 919:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 920:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 921:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 922:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 923:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 924:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 925:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 926:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 927:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 928:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 929:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 930:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 931:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 932:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4- methylphenyl；X is
Compound 933:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 934:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 935:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 936:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 937:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 938:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 939:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 940:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 941:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 942:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 943:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 944:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 945:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 946:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 947:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 948:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 949:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 950:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 951:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 952:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 953:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 954:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 955:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 956:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 957:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 958:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 959:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- Dimethvl-phenyl；X is
Compound 960:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 961:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 962:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 963:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 964:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 965:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 966:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 967:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 968:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 969:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 970:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 971:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 972:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 973:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 974:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 975:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 976:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 977:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 978:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 979:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 980:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 981:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 982:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 983:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 984:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 985:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 986:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X is
Compound 987:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 988:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 989:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 990:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 991:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 992:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 993:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 994:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 995:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 996:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 997:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 998:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 999:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1000:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1001:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1002:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1003:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1004:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1005:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1006:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1007:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1008:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1009:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1010:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1011:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1012:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1013:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dimethvl-phenyl；X is
Compound 1014:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1015:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1016:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1017:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1018:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1019:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1020:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1021:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1022:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1023:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1024:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1025:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1026:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1027:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1028:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1029:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1030:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1031:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1032:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1033:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1034:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1035:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1036:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1037:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1038:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1039:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1040:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,5- Dimethvl-phenyl；X is
Compound 1041:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1042:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1043:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1044:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1045:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1046:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1047:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1048:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1049:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1050:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1051:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1052:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1053:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1054:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1055:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1056:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1057:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1058:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1059:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1060:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1061:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1062:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1063:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1064:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1065:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1066:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1067:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 2-；X is
Compound 1068:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1069:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1070:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1071:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1072:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1073:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1074:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1075:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1076:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1077:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1078:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1079:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1080:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1081:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1082:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1083:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1084:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1085:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1086:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1087:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1088:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1089:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1090:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1091:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1092:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1093:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1094:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 3-；X is
Compound 1095:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1096:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1097:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1098:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1099:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1100:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1101:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1102:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1103:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1104:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1105:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1106:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1107:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1108:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1109:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1110:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1111:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1112:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1113:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1114:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1115:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1116:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1117:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1118:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1119:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1120:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1121:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is the bromo- phenyl of 4-；X is
Compound 1122:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1123:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1124:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1125:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1126:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1127:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1128:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1129:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1130:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1131:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1132:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1133:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1134:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1135:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1136:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1137:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1138:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1139:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1140:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1141:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1142:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1143:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1144:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1145:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1146:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1147:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1148:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- dibromo-phenyl；X is
Compound 1149:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1150:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1151:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1152:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1153:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1154:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1155:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1156:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1157:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1158:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1159:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1160:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1161:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1162:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1163:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1164:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1165:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1166:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1167:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1168:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1169:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1170:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1171:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1172:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1173:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1174:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1175:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- dibromo-phenyl；X is
Compound 1176:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1177:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1178:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1179:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 0:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 1:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 2:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 3:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 4:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 5:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 6:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 7:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 8:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 118 9:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1190:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1191:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1192:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1193:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1194:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1195:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1196:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1197:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1198:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1199:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1200:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1201:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1202:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- methoxyl group-phenyl；X is
Compound 1203:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1204:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1205:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1206:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1207:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1208:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1209:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1210:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1211:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1212:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1213:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1214:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1215:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1216:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1217:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1218:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1219:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1220:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1221:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1222:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1223:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1224:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1225:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1226:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1227:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1228:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1229:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethoxy-phenyl；X is
Compound 1230:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1231:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1232:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1233:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1234:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1235:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1236:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1237:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1238:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1239:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1240:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1241:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1242:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1243:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1244:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1245:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1246:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1247:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1248:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1249:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1250:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1251:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1252:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1253:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1254:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1255:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1256:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- trifluoromethyl-phenyl；X is
Compound 1257:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1258:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1259:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1260:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1261:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1262:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1263:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1264:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1265:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1266:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1267:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1268:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1269:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1270:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1271:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1272:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1273:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1274:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1275:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1276:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1277:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1278:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1279:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1280:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1281:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is benzyl；X is
Compound 1282:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1283:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1284:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1285:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1286:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1287:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1288:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1289:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1290:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1291:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1292:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1293:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1294:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1295:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1296:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1297:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1298:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1299:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1300:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1301:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1302:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1303:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1304:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1305:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1306:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1307:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1308:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene；X is
Compound 1309:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1310:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1311:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1312:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1313:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1314:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1315:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1316:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1317:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1318:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1319:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1320:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1321:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1322:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1323:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1324:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1325:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1326:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1327:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1328:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1329:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1330:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1331:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1332:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1333:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1334:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3- naphthalene；X is
Compound 1335:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1336:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1337:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1338:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1339:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1340:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1341:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1342:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1343:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1344:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1345:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1346:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1347:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；YX is
Compound 1348:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1349:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1350:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1351:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；YX is
Compound 1352:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1353:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1354:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1355:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1356:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1357:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1358:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1360:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1361:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1362:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1363:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1364:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1365:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1366:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1367:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1368:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1369:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1370:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1371:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1372:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1373:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1374:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1375:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1376:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1377:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX
For
Compound 1378:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1379:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1380:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1382:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1383:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1384:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1385:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1386:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1387:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1388:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1389:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1390:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1391:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1392:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1393:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1394:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1395:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1396:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1397:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1398:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1399:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1401:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1402:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1403:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1404:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1405:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1406:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1407:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1408:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1409:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1410:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1411:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1412:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1413:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y isX is
Compound 1418:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1419:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1420:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1421:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1422:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1423:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1424:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1425:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1426:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1427:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1428:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1429:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1430:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1431:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1432:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1433:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1434:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1435:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1436:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1437:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1438:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is
Compound 1439:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is phenyl；X is-OH；
Compound 1440:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1441:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1442:R1For-CH3；R2For-CH3；R3For-CH2CH2CH3；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1443:R1For-CH3；R2For-CH3；R3For-CH2CH(CH3)2；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1444:R1For-CH3；R2For-CH3；R3For n- (CH2)3CH3；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1445:R1For-CH3；R2For-CH3；R3For-CH2C6H5；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1446:R1For-CH3；R2For-CH3；R3For-CH2CHCH2；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1447:R1For-CH3；R2For-CH3；R3For-CHCCH；R4For H；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1448:R1For-CH3；R2For-CH3；R3For-CH2(3-OCH3)C6H4；R4For H；Z is O；Y is 2-CH3-Ph；X be-
OH；
Compound 1449:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-CH3-Ph；X is-OH；
Compound 1450:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH2CH3-Ph；X is-OH；
Compound 1451:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-CH2CH3-Ph；X is-OH；
Compound 1452:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH (CH3)2-Ph；X is-OH；
Compound 1453:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-F-Ph；X is-OH；
Compound 1454:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 3-F-Ph；X is-OH；
Compound 1455:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-F-Ph；X is-OH；
Compound 1456:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-Cl-Ph；X is-OH；
Compound 1457:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 3-Cl-Ph；X is-OH；
Compound 1458:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-Cl-Ph；X is-OH；
Compound 1459:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-Br-Ph；X is-OH；
Compound 1460:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 3-Br-Ph；X is-OH；
Compound 1461:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-Br-Ph；X is-OH；
Compound 1462:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-NO2-Ph；X is-OH；
Compound 1463:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-CF3-Ph；X is-OH；
Compound 1464:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-OCH3-Ph；X is-OH；
Compound 1465:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-OCH3-Ph；X is-OH；
Compound 1466:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-OCF3-Ph；X is-OH；
Compound 1467:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-OCF3-Ph；X is-OH；
Compound 1468:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2,6- Dimethvl-phenyl；X is-OH；
Compound 1469:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2,6- Diethyl-phenyl；X is-OH；
Compound 1470:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2,6- Diethyl-phenyl；X be-
OH；
Compound 1471:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2,6- Diisopropyl-phenyl；X
For-OH；
Compound 1472:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2,4,6- trimethyl-phenyl；X be-
OH；
Compound 1473:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH3-4-NO2-Ph；X is-OH；
Compound 1474:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2-CH3-4-Cl-Ph；X is-OH；
Compound 1475:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2-CH3-4-Cl-Ph；X is-OH；
Compound 1476:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-Cl-4-NO2-Ph；X is-OH；
Compound 1477:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2,4- Dichloro-phenyl；X is-OH；
Compound 1478:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 2,4- Dichloro-phenyl；X is-OH；
Compound 1479:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH3-6-Cl-Ph；X is-OH；
Compound 1480:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 2-CH3-3-F-Ph；X is-OH；
Compound 1481:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 3-F-Ph；X is-OH；
Compound 1482:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 3,5- difluorophenyl；X is-OH；
Compound 1483:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For H；Z is O；Y is 3,5- difluorophenyl；X is-OH；
Compound 1484:R1For-CH3；R2For-CH3；R3For-CH3；R4For H；Z is O；Y is 4-OC6H5-Ph；X is-OH；
Compound 1485:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1486:R1For-CH3；R2For-CH3；R3For-n-C3H7；R4For-CH3；Z is O；Y is 2-CH3-Ph；X is-OH；
Compound 1487:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3-CH3-Ph；X is-OH；
Compound 1488:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-CH3-Ph；X is-OH；
Compound 1489:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 4-CH3-Ph；X is-OH；
Compound 1490:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH2CH3-Ph；X is-OH；
Compound 1491:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 2-CH2CH3-Ph；X is-OH；
Compound 1492:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 2-OCH3-Ph；X is-OH；
Compound 1493:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-CH2CH3-Ph；X is-OH；
Compound 1494:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dimethvl-phenyl；X be-
OH；
Compound 1495:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is-OH；
Compound 1496:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 2-Cl-Ph；X is-OH；
Compound 1497:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 3-Cl-Ph；X is-OH；
Compound 1498:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Cl-Ph；X is-OH；
Compound 1499:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-F-Ph；X is-OH；
Compound 1500:R1For-CH3；R2For-CH3；R3For-CH2CH3；R4For-CH3；Z is O；Y is 2-F-Ph；X is-OH；
Compound 1501:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-F-Ph；X is-OH；
Compound 1502:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3-Br-Ph；X is-OH；
Compound 1503:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-Br-Ph；X is-OH；
Compound 1504:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4,6- trichloro-pheny；X be-
OH；
Compound 1505:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,4- difluorophenyl；X is-OH；
Compound 1506:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,3- Dichloro-phenyl；X is-OH；
Compound 1507:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 4-CF3-Ph；X is-OH；
Compound 1508:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CF3-Ph；X is-OH；
Compound 1509:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2,6- Dichloro-phenyl；X is-OH；
Compound 1510:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2-CH (CH3)2-Ph；X is-OH；
Compound 1511:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 3-F-Ph；X is-OH；
Compound 1512:R1For-CH3；R2For-CH3；R3For-CH3；R4For-CH3；Z is O；Y is 2- naphthalene nucleus；X is-OH.
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| CN110357861A (en) * | 2018-04-11 | 2019-10-22 | 山东先达农化股份有限公司 | A kind of pyrazoles quinazoline diones class compound and its application and a kind of pesticide herbicide |
| CN113149913A (en) * | 2020-01-07 | 2021-07-23 | 山东先达农化股份有限公司 | alpha-C position modified benzyl substituted quinazoline diketone compound, preparation method and application thereof, and HPPD herbicide |
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| CN114573516B (en) * | 2020-11-30 | 2023-10-24 | 山东先达农化股份有限公司 | Trione-quinazolinone compound, preparation method and application thereof, and herbicide |
| CN114989142A (en) * | 2022-05-09 | 2022-09-02 | 沈阳万菱生物技术有限公司 | Preparation method of pyrazole compound |
| WO2024008191A1 (en) * | 2022-07-08 | 2024-01-11 | 山东先达农化股份有限公司 | Quinazolinedione-containing compound, method for preparing same, and use thereof |
| CN117624136A (en) * | 2022-09-01 | 2024-03-01 | 山东先达农化股份有限公司 | Compound containing pyrazole-quinazoline dione structure, herbicide and application |
| CN115843819B (en) * | 2022-12-28 | 2024-04-05 | 安徽众邦生物工程有限公司 | Composition containing mequindox and fluropyridine ester |
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| WO2017140612A1 (en) * | 2016-02-18 | 2017-08-24 | Bayer Cropscience Aktiengesellschaft | Quinazolinedione-6-carbonyl derivatives and their use as herbicides |
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| WO1997008164A1 (en) * | 1995-08-25 | 1997-03-06 | E.I. Du Pont De Nemours And Company | Bicyclic herbicides |
| CA2281904A1 (en) * | 1997-04-25 | 1998-11-05 | E.I. Du Pont De Nemours And Company | Herbicidal pyrazoles |
| GB201416111D0 (en) * | 2014-09-12 | 2014-10-29 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| CN106146414A (en) * | 2016-07-07 | 2016-11-23 | 浙江大学 | Quinazoline diones analog derivative and its production and use |
| CN110357860B (en) * | 2018-04-11 | 2020-12-15 | 山东先达农化股份有限公司 | Quinazoline diketone compound and application thereof as well as pesticide herbicide |
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| CN1355164A (en) * | 2000-11-30 | 2002-06-26 | 沈阳化工研究院 | 3-(2-fluo-4,5,6-substituted phenyl)-1,3-quinazoline-2,4-dione compound with herbiciding activity |
| CN104557739A (en) * | 2013-10-25 | 2015-04-29 | 华中师范大学 | Triketone compound and preparation method and application thereof |
| WO2017140612A1 (en) * | 2016-02-18 | 2017-08-24 | Bayer Cropscience Aktiengesellschaft | Quinazolinedione-6-carbonyl derivatives and their use as herbicides |
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| CN110357861A (en) * | 2018-04-11 | 2019-10-22 | 山东先达农化股份有限公司 | A kind of pyrazoles quinazoline diones class compound and its application and a kind of pesticide herbicide |
| CN110357861B (en) * | 2018-04-11 | 2021-02-19 | 山东先达农化股份有限公司 | Pyrazole quinazoline diketone compound and application thereof as well as pesticide herbicide |
| CN113149913A (en) * | 2020-01-07 | 2021-07-23 | 山东先达农化股份有限公司 | alpha-C position modified benzyl substituted quinazoline diketone compound, preparation method and application thereof, and HPPD herbicide |
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| WO2019196904A1 (en) | 2019-10-17 |
| CN110357860A (en) | 2019-10-22 |
| CN110357859B (en) | 2020-09-04 |
| JP2021517592A (en) | 2021-07-26 |
| CN110357859A (en) | 2019-10-22 |
| CN110357861B (en) | 2021-02-19 |
| WO2019196908A1 (en) | 2019-10-17 |
| JP7082709B2 (en) | 2022-06-08 |
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| CN110357860B (en) | 2020-12-15 |
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