CN110354029A - A kind of adjustment type milky lotion and preparation method thereof - Google Patents
A kind of adjustment type milky lotion and preparation method thereof Download PDFInfo
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Abstract
A kind of adjustment type milky lotion disclosed by the invention, by weight percentage, it is made of following raw material components: glycerol 3-5%, butanediol 3-5%, carbomer 0.15-0.5%, triethanolamine 0.15-0.5%, ceramide 0.1-0.2%, hydrolecithin 0.5-2%, dimethyl silicone polymer 3-6%, composition 5-10%, the moutan root bark extracting solution 1-5%, deionized water 67-84% for adjusting smegma.Wherein, the group of the composition for adjusting sebum secretion amount becomes isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract.Preparation method includes ingredient, homogeneous and stirring.A kind of adjustment type milky lotion provided by the invention and preparation method thereof, the adjustment type milky lotion prepared by the above method is mild safely, can effective moisturizing, and be adjustable sebum secretion amount, there is preferable pore refining effect, and its preparation is convenient, is easy to industrialization.
Description
Technical field
The present invention relates to cosmetic technical fields, more particularly, to a kind of adjustment type milky lotion and preparation method thereof.
Background technique
As people's lives level increasingly improves, the quality and functional requirement to beauty, skin-protection product are also more next
It is higher.Skin-protection product available on the market is although various, but many products more or less add chemical substance, long-time service pair
Skin has certain nocuity.And many skin care item have a single function, it is difficult to meet the requirements of consumers.And milky lotion is conduct
One kind of lotion, can deeply moisten dry skin, and the water % that supplement skin is lost daily is almost used by consumer everyday.Cause
This, the safety of milky lotion and functionality are paid close attention to by consumer.And to there is water oil unbalanced more for the skin of many consumers
Often there is the case where hypersteatosis in problem, this can not only cause glowing skin, make up floating powder, pore coarse, can also draw
Send out skin disease some, such as acne, acne.In addition, plant material is comparatively safe compared with chemical substance, especially it is used as medicine
Plant safety is more reliable, therefore, researches and develops one kind using plant material as main component, can effectively adjust sebaceous glands point
The adjustment type milky lotion for secreting sebum is necessary.
Summary of the invention
In order to overcome above-mentioned technical problem of the existing technology, the first object of the present invention is to provide a kind of safety temperature
With, can effective moisturizing, and be adjustable sebum secretion amount, the adjustment type milky lotion of pore refining.
To solve the above-mentioned problems, the present invention is achieved by following technical scheme: a kind of adjustment type milky lotion, by weight
Percentages are measured, are made of following raw material components:
Glycerol 3-5%, butanediol 3-5%, carbomer 0.15-0.5%, triethanolamine 0.15-0.5%, ceramide
0.1-0.2%, hydrolecithin 0.5-2%, dimethyl silicone polymer 3-6%, adjust smegma composition 5-10%,
Moutan root bark extracting solution 1-5%, deionized water 67-84%；Wherein, the group of the composition for adjusting sebum secretion amount becomes big
Beans isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract.
Glycerol can as the moisturizer in cosmetics, contain in glycerol molecule there are three-OH can form hydrogen with hydrone
Key can firmly lock hydrone, play moistening effect, and glycerol has apparent moisten to imitate the skin tissue of human body
Fruit can increase the dissolubility of cosmetics, it is easier to permeate；Glycerol can also repair skin barrier as moisturizer, and protect
Sheath skin adjusts the hydration function of skin, can not only increase the water content of skin, improves dry skin, for outer
The stimulation on boundary also has certain protective effect, can promote the self-regeneration of damaged cell.
Polyalcohol and carbomer have brilliant water imbibition, rest on skin surface after absorption moisture and play moisture-keeping function,
Triethanolamine neutralizes carbomer for adjusting pH value；Ceramide and hydrolecithin are the important components of skin composition, can
Repair skin injury；Dimethyl silicone polymer being capable of soft and moist skin；
The present invention can effectively repair skin, and by isoflavones, Barosma betulina leaf extract, Burdok root P.E, elm
Ramulus et Folium Spiraeae Salicifoliae extract, moutan root bark extract carry out scientific compatibility, coordinative role, the flavonoids being rich in by said extracted object
(predominantly flavones, isoflavones, diosmin), phenols (predominantly tannin, Paeonol) and glycoside (root bark of tree peony original glycosides, Paeoniflorin) are changed
It closes object to work, sebum secretion amount can not only be adjusted, also there is moisture-keeping function；Flavone compound, have inhibit androgen,
The activity of Aminopeptidase N and 5 alpha-reductases adjusts sebum secretion amount, and has inhibiting effect to oxygen radical, can inhibit free radical pair
The injury of Skin Cell avoids skin moisture caused by due to radical damage cell from being lost, there is moistening effect；Phenols and glycoside
Compound has obvious inhibiting effect to bacterium, and synergistic effect increases antibacterial range, and the hydroxyl being rich in has water imbibition, can adsorb molten
Moisture in agent or environment has moisture-keeping function to skin and can promote pore refining effect.
Preferably, percentage, the composition of the composition for adjusting sebum secretion amount are as follows: the different Huang of soybean
Ketone 20-30%, the Barosma betulina leaf extract 25-40%, the radix bardanae extracting solution 30-45% and the Spiraea ulmaria extract
Object 3-4%.Passing through for the composition for adjusting sebum secretion amount rationally compounds, and makes it have preferably adjusting smegma
The amount of sebum.
Preferably, the moutan root bark extracting solution extracting method includes the following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 40-60 DEG C, takes out tree peony later
Root skin is simultaneously crushed to 40 mesh, spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnated
After 12-24 hours, after applying the ultrasonication 4-8min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) filter: by the resulting moutan root bark mixed extract of step 2) be transferred to temperature be 30-40 DEG C under conditions of it is quiet
It is filtered after setting 20-40min, gained filtrate is moutan root bark extracting solution.
Moutan root bark extracting solution has preferable contraction to collagen fabric gel, can promote composition convergence pore
Effect, and have good antibacterial and antiphlogistic effects, have promotion to the effect of combination gained milky lotion various aspects.
Preferably, the extracting method of the isoflavones includes the following steps:
1) feedstock processing: being crushed to partial size in 0.5-0.8mm for soybean meal, spare；
2) solvent extraction: the resulting soybean meal of step 1) is extracted with the ethanol water that concentration is 40-80%, raw material
Solid-liquid ratio with solvent is 1g:8-16mL, and Extracting temperature is 60-80 DEG C, extraction time 5-8h, and extraction time is 1-3 times, is obtained
To extracting solution；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 5- of obtained extraction object
10h；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the cutting point of ultrafiltration membrane with ultrafiltration membrane
Son amount is 600-100000, by the leaching liquor temperature of ultrafiltration membrane at 80-90 DEG C, then it is big in resin adsorption leaching liquor with adsorbing
Beans isoflavones；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain powdery soybean
Isoflavones；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99
It closes, the as described isoflavones.
The molecular structure of isoflavones and human endogenous's property estrogen estradiol are very much like, therefore have estrogen living
Property, have estrogen-like action, skin is one of the target tissue that estrogen plays a role, estrogen by on Skin Cell
Estrogen receptor, which combines, plays biological effect, it has the function of promoting collagen and hyaluronic acid synthesis, keeps skin fine and smooth, clean
White, high resilience and gloss, and it is inhibited to androgen, to inhibit androgen to sebocyte cell sebum secreted
It influences；Isoflavones can also inhibit free radical to the injury of Skin Cell, avoid flesh caused by due to radical damage cell
Skin water loss.
Preferably, the Barosma betulina leaf extract is made through the method for microwave abstracting；Wherein, the Barosma betulina leaf extract
Extractant used be butanediol aqueous solution, microwave frequency 400-250000MHz, and when microwave frequency be 2450MHz when extract
Take effect preferable.
Barosma betulina leaf extract is rich in flavonoids, and chief active molecule is diosmin, can inhibit precursor sebocyte cell
Differentiation, and secretion of the mature sebocyte cell to grease have fine and smooth pore, control fat secretion, restore skin natural light
The effect in pool.
Preferably, the extracting method of the radix bardanae extracting solution includes the following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:12-24mL, in 50-70
Refluxing extraction is three times, 3.5-4.5 hours each at a temperature of DEG C, obtains extracting solution；
3) filtering and concentrating: by the filtering of step 2) resulting extracting solution and merging filtrate, using rotary evaporator to filtrate into
Row is concentrated by evaporation, and obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), with temperature after degreasing concentrate
The baking oven forced air drying that degree is 75-85 DEG C, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) is prepared into the Burdok root P.E aqueous solution of 0.01g/mL, it will
Macroreticular resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 20-30 DEG C of constant temperature is kept, static
Absorption 1-4 hours, obtains the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, it is added
The ethanol solution of concentration 15-60% elutes, and elution speed 1.25-2.75BV/h collects eluent after elution, is concentrated and dried and is
Powdery Burdok root P.E；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed with the ratio of 1:4,
The as described radix bardanae extracting solution.
Radix bardanae extracting solution also has inhibiting effect to androgen levels, cooperates with isoflavones, and antibacterial action can rise
To antiphlogistic effects.
Preferably, the extracting method of the Spiraea ulmaria extract includes the following steps:
1) Hua Heye for choosing Spiraea ulmaria, uses concentration 55-65% ethanol solution as solvent, Extracting temperature 65-75
DEG C, extraction time is 2 times, and each extraction time is 1.5-2.5 hours, and each solvent usage is 10 times of Spiraea ulmaria weight,
Filtering, obtains the first extracting solution and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, mistake
Filter, obtains the first medical fluid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then with concentration 75-
85% ethanol solution elution, collects 75-85% concentration ethanol eluent, is concentrated and dried to get the first Spiraea ulmaria extract；
3) by resulting first dregs of a decoction of step 1), use concentration 2-3% hydrochloric acid solution as solvent, 65-75 DEG C of Extracting temperature,
Extraction time is 2 times, and each extraction time is 1.5-2.5 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, mistake
Filter, combined extract are concentrated into relative density d=1.16, with ammonium hydroxide tune pH to 9-10, are extracted with ethyl acetate 4 times, acetic acid second
After ester extract liquor is washed with water 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) is mixed
The even Spiraea ulmaria extract to get powdery.
Spiraea ulmaria extract can inhibit the generation of inflammation, cooperate with isoflavones, have inhibiting effect, and energy to androgen
Keep skin moisture, pore refining.
To solve the above-mentioned problems, there is provided the preparation method of adjustment type milky lotion, behaviour for the second object of the present invention
Make simply, preparation is convenient, is easy to industrialization.
To solve the above-mentioned problems, the present invention is achieved by following technical scheme:
A kind of preparation method of adjustment type milky lotion, includes the following steps:
S01 ingredient: it is equipped with following raw material: 3-5% glycerol, 3-5% butanediol, 0.15-0.5% card wave by weight percentage
Nurse, 0.15-0.5% triethanolamine, 0.1-0.2% ceramide, 0.5-2% hydrolecithin, 3-6% polydimethylsiloxanes
Alkane, 5-10% adjust composition, 1-5% moutan root bark extracting solution and the 67-84% deionized water of smegma；Wherein, institute
The group for adjusting the composition of sebum secretion amount is stated as isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, elm embroider line
Chrysanthemum extract；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, institute
It states hydrolecithin, the dimethyl silicone polymer, sequentially add homogenizer, add the deionized water, be heated to 80-85
DEG C, heat preservation opened homogenizer after 8-15 minutes, makes its emulsification in uniform bright emulsion form, stops homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 40-45 DEG C, add the adjusting skin
The composition of adipose gland secretory volume and the moutan root bark extracting solution, homogeneous 1-5 minutes, are added the triethanolamine, stir evenly
To room temperature to get the adjustment type milky lotion.
Preferably, the preparation of the composition for adjusting sebum secretion amount includes the following steps:
S01: as needed, following raw material: isoflavones 20-30%, Barosma betulina leaf extract is weighed respectively in proportion
25-40%, radix bardanae extracting solution 30-45% and Spiraea ulmaria extract 3-4%；
S02: the soybean different Huang is sequentially added when the temperature of blender is adjusted to 40-45 DEG C into the mixing drum of blender
Ketone, the Barosma betulina leaf extract, the radix bardanae extracting solution and the Spiraea ulmaria extract are opened blender stirring, are stirred
It mixes uniformly to room temperature, the composition of the tune section sebum secretion amount is made.
Compared with prior art, the beneficial effects of the present invention are:
1. the adjustment type milky lotion that the present invention is prepared can effectively repair skin, and by isoflavones, Barosma betulina
Leaf extract, Burdok root P.E, Spiraea ulmaria extract, moutan root bark extract carry out scientific compatibility, and coordinative role passes through
Flavonoids (predominantly flavones, isoflavones, diosmin) that said extracted object is rich in, phenols (predominantly tannin, Paeonol) and
Glycoside (root bark of tree peony original glycosides, Paeoniflorin) compound works, and can not only adjust sebum secretion amount, also has moisture-keeping function, and institute
The main component stated is plant extracts, and safety is higher；Flavone compound, have inhibit androgen, Aminopeptidase N and
The activity of 5 alpha-reductases adjusts sebum secretion amount, and has inhibiting effect to oxygen radical, free radical can be inhibited to Skin Cell
Injury avoids skin moisture caused by due to radical damage cell from being lost, there is moistening effect；Phenols and glycosides compound are to thin
Bacterium has an obvious inhibiting effect, and synergistic effect increases antibacterial range, and the hydroxyl being rich in has water imbibition, can be in adsorption solvent or environment
Moisture, have moisture-keeping function to skin and pore refining effect can be promoted.
2. the preparation method of adjustment type milky lotion of the present invention, easy to operate, preparation is convenient, is easy to industrialization.
Specific embodiment
The present invention is further analyzed combined with specific embodiments below, it is clear that described is only the present invention one
Section Example, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
Barosma betulina leaf used in adjustment type milky lotion is prepared in the following embodiments of the present invention from South America and South Africa crop
Growing area is bought in ProvitalGroup company, Spain；Radix bardanae comes from domestic shop of Chinese medicines；Spiraea ulmaria is domestic plantation
Native country Spiraea ulmaria, have a cultivation on Liaoning, the Inner Mongol, Hebei, Shandong, Shanxi and other places, buy in domestic shop of Chinese medicines, it is other
Raw material and solvent are commercial product.
Embodiment 1
One, the preparation of raw material
(1) moutan root bark extracting solution extracting method includes the following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 40 DEG C, takes out tree peony root later
Skin is simultaneously crushed to 40 mesh, spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnated
After 24 hours, after applying the ultrasonication 4min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) it filters: the resulting moutan root bark mixed extract of step 2) being transferred under conditions of temperature is 40 DEG C and is stood
It is filtered after 20min, gained filtrate is moutan root bark extracting solution.
(2) extracting method of isoflavones includes the following steps:
1) feedstock processing: being crushed to partial size in 0.5mm for soybean meal, spare；
2) solvent extraction: by the resulting soybean meal concentration of step 1) be 80% ethanol water extract, raw material with
The solid-liquid ratio of solvent is 1g:8mL, and Extracting temperature is 80 DEG C, extraction time 5h, and extraction time is 3 times, obtains extracting solution；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 10h of obtained extraction object；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the cutting point of ultrafiltration membrane with ultrafiltration membrane
Son amount be 600, by the leaching liquor temperature of ultrafiltration membrane at 90 DEG C, then with adsorb resin adsorption leaching liquor in isoflavones；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain powdery soybean
Isoflavones；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99
It closes, the as described isoflavones.
(3) Barosma betulina leaf extract is made through the method for microwave abstracting, and extractant used is butanediol aqueous solution, micro-
Wave frequency rate is 400MHz.
(4) extracting method of radix bardanae extracting solution includes the following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:24mL, in 50 DEG C of temperature
It spends lower refluxing extraction three times, 4.5 hours every time, obtains extracting solution；
3) filtering and concentrating: by the filtering of step 2) resulting extracting solution and merging filtrate, using rotary evaporator to filtrate into
Row is concentrated by evaporation, and obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), with temperature after degreasing concentrate
The baking oven forced air drying that degree is 75 DEG C, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) is prepared into the Burdok root P.E aqueous solution of 0.01g/mL, it will
Macroreticular resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 30 DEG C of constant temperature, Static Adsorption are kept
1 hour, obtain the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, concentration is added
60% ethanol solution elution, elution speed 1.25BV/h collect eluent after elution, are concentrated and dried and mention for powdery radix bardanae
Take object；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed with the ratio of 1:4,
The as described radix bardanae extracting solution.
(5) extracting method of Spiraea ulmaria extract includes the following steps:
1) Hua Heye for choosing Spiraea ulmaria uses 65% ethanol solution of concentration as solvent, and Extracting temperature is 65 DEG C, extracts
Number is 2 times, and each extraction time is 2.5 hours, and each solvent usage is 10 times of Spiraea ulmaria weight, and filtering obtains first
Extracting solution and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, filters, obtains first
Medical fluid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then uses concentration
75% ethanol solution elution, collects 75% concentration ethanol eluent, is concentrated and dried to get the first Spiraea ulmaria extract；
3) it by resulting first dregs of a decoction of step 1), uses 2% hydrochloric acid solution of concentration as solvent, 75 DEG C of Extracting temperature, extracts
Number is 2 times, and each extraction time is 1.5 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, is filtered, and merging mentions
Liquid is taken, relative density d=1.16 is concentrated into, with ammonium hydroxide tune pH to 10, is extracted with ethyl acetate 4 times, acetic acid ethyl acetate extract is used
After washing 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) is mixed
The even Spiraea ulmaria extract to get powdery.
(6) preparation of the composition of sebum secretion amount is adjusted:
When the temperature of blender is adjusted to 40 DEG C, 20g isoflavones, 40g are sequentially added into the mixing drum of blender
Barosma betulina leaf extract, 36g radix bardanae extracting solution and 4g Spiraea ulmaria extract are opened blender stirring, are evenly stirred until often
The composition of the tune section sebum secretion amount is made in temperature.
Two, the adjustment type milky lotion of 100g is prepared, by weight percentage, each raw material components accounts in the milky lotion
Than as follows:
Glycerol 3%, butanediol 4.5%, carbomer 0.2%, triethanolamine 0.2%, ceramide 0.1%, hydrogenation lecithin
Rouge 2%, dimethyl silicone polymer 6%, composition 5%, the moutan root bark extracting solution 5%, deionized water for adjusting smegma
74%.
Three, the preparation method of adjustment type milky lotion
S01 ingredient: with following raw material by weight percentage: 3% glycerol, 4.5% butanediol, 0.2% carbomer,
0.2% triethanolamine, 0.1% ceramide, 2% hydrolecithin, 6% dimethyl silicone polymer, 5% adjust smegma
Composition, 5% moutan root bark extracting solution and 74% deionized water；Wherein, the group of the composition for adjusting sebum secretion amount
As isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, institute
It states hydrolecithin, the dimethyl silicone polymer, sequentially add homogenizer, add the deionized water, be heated to 80 DEG C,
Heat preservation opened homogenizer after 15 minutes, makes its emulsification in uniform bright emulsion form, stops homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 40 DEG C, add the adjusting sebaceous glands
The composition of secretory volume and the moutan root bark extracting solution, homogeneous 5 minutes, are added the triethanolamine, are evenly stirred until room temperature,
Up to the adjustment type milky lotion.
Embodiment 2
One, the preparation of raw material
(1) moutan root bark extracting solution extracting method includes the following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 60 DEG C, takes out tree peony root later
Skin is simultaneously crushed to 40 mesh, spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnated
After 12 hours, after applying the ultrasonication 8min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) it filters: the resulting moutan root bark mixed extract of step 2) being transferred under conditions of temperature is 30 DEG C and is stood
It is filtered after 40min, gained filtrate is moutan root bark extracting solution.
(2) extracting method of isoflavones includes the following steps:
1) feedstock processing: being crushed to partial size in 0.8mm for soybean meal, spare；
2) solvent extraction: by the resulting soybean meal concentration of step 1) be 40% ethanol water extract, raw material with
The solid-liquid ratio of solvent is 1g:16mL, and Extracting temperature is 60 DEG C, extraction time 10h, and extraction time is 1 time, obtains extracting solution；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 5h of obtained extraction object；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the cutting point of ultrafiltration membrane with ultrafiltration membrane
Son amount be 100000, by the leaching liquor temperature of ultrafiltration membrane at 80 DEG C, then with adsorb resin adsorption leaching liquor in the different Huang of soybean
Ketone；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain powdery soybean
Isoflavones；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99
It closes, the as described isoflavones.
(3) Barosma betulina leaf extract is made through the method for microwave abstracting, and extractant used is butanediol aqueous solution, micro-
Wave frequency rate is 250000MHz.
(4) extracting method of radix bardanae extracting solution includes the following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:12mL, in 70 DEG C of temperature
It spends lower refluxing extraction three times, 3.5 hours every time, obtains extracting solution；
3) filtering and concentrating: by the filtering of step 2) resulting extracting solution and merging filtrate, using rotary evaporator to filtrate into
Row is concentrated by evaporation, and obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), with temperature after degreasing concentrate
The baking oven forced air drying that degree is 85 DEG C, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) is prepared into the Burdok root P.E aqueous solution of 0.01g/mL, it will
Macroreticular resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 20 DEG C of constant temperature, Static Adsorption are kept
4 hours, obtain the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, concentration is added
15% ethanol solution elution, elution speed 2.75BV/h collect eluent after elution, are concentrated and dried and mention for powdery radix bardanae
Take object；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed with the ratio of 1:4,
The as described radix bardanae extracting solution.
(5) extracting method of Spiraea ulmaria extract includes the following steps:
1) Hua Heye for choosing Spiraea ulmaria uses 55% ethanol solution of concentration as solvent, and Extracting temperature is 75 DEG C, extracts
Number is 2 times, and each extraction time is 1.5 hours, and each solvent usage is 10 times of Spiraea ulmaria weight, and filtering obtains first
Extracting solution and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, filters, obtains first
Medical fluid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then uses concentration
85% ethanol solution elution, collects 85% concentration ethanol eluent, is concentrated and dried to get the first Spiraea ulmaria extract；
3) it by resulting first dregs of a decoction of step 1), uses 3% hydrochloric acid solution of concentration as solvent, 65 DEG C of Extracting temperature, extracts
Number is 2 times, and each extraction time is 2.5 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, is filtered, and merging mentions
Liquid is taken, relative density d=1.16 is concentrated into, with ammonium hydroxide tune pH to 9, is extracted with ethyl acetate 4 times, acetic acid ethyl acetate extract water
After washing 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) is mixed
The even Spiraea ulmaria extract to get powdery.
(6) preparation of the composition of sebum secretion amount is adjusted:
When the temperature of blender is adjusted to 45 DEG C, 27g isoflavones, 25g are sequentially added into the mixing drum of blender
Barosma betulina leaf extract, 45g radix bardanae extracting solution and 3g Spiraea ulmaria extract are opened blender stirring, are evenly stirred until often
The composition of the tune section sebum secretion amount is made in temperature.
Two, the adjustment type milky lotion of 100g is prepared, by weight percentage, each raw material components accounts in the milky lotion
Than as follows:
Glycerol 3%, butanediol 3%, carbomer 0.15%, triethanolamine 0.15%, ceramide 0.2%, hydrogenation lecithin
Rouge 0.5%, dimethyl silicone polymer 3%, composition 5%, the moutan root bark extracting solution 1%, deionization for adjusting smegma
Water 84%.
Three, the preparation method of adjustment type milky lotion
S01 ingredient: with following raw material by weight percentage: 3% glycerol, 3% butanediol, 0.15% carbomer,
0.15% triethanolamine, 0.2% ceramide, 0.5% hydrolecithin, 3% dimethyl silicone polymer, 5% adjust sebaceous glands
The composition of secretion, 1% moutan root bark extracting solution and 84% deionized water；Wherein, the composition for adjusting sebum secretion amount
Group become isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, institute
It states hydrolecithin, the dimethyl silicone polymer, sequentially add homogenizer, add the deionized water, be heated to 85 DEG C,
Heat preservation opened homogenizer after 8 minutes, makes its emulsification in uniform bright emulsion form, stops homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 45 DEG C, add the adjusting sebaceous glands
The composition of secretory volume and the moutan root bark extracting solution, homogeneous 1 minute, are added the triethanolamine, are evenly stirred until room temperature,
Up to the adjustment type milky lotion.
Embodiment 3
One, the preparation of raw material
(1) moutan root bark extracting solution extracting method includes the following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 50 DEG C, takes out tree peony root later
Skin is simultaneously crushed to 40 mesh, spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnated
After 18 hours, after applying the ultrasonication 6min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) it filters: the resulting moutan root bark mixed extract of step 2) being transferred under conditions of temperature is 35 DEG C and is stood
It is filtered after 30min, gained filtrate is moutan root bark extracting solution.
(2) extracting method of isoflavones includes the following steps:
1) feedstock processing: being crushed to partial size in 0.6mm for soybean meal, spare；
2) solvent extraction: by the resulting soybean meal concentration of step 1) be 60% ethanol water extract, raw material with
The solid-liquid ratio of solvent is 1g:12mL, and Extracting temperature is 70 DEG C, extraction time 6h, and extraction time is 2 times, obtains extracting solution；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 8h of obtained extraction object；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the cutting point of ultrafiltration membrane with ultrafiltration membrane
Son amount be 5000, by the leaching liquor temperature of ultrafiltration membrane at 85 DEG C, then with adsorb resin adsorption leaching liquor in isoflavones；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain powdery soybean
Isoflavones；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99
It closes, the as described isoflavones.
(3) Barosma betulina leaf extract is made through the method for microwave abstracting, and extractant used is butanediol aqueous solution, micro-
Wave frequency rate is 2450MHz.
(4) extracting method of radix bardanae extracting solution includes the following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:18mL, in 60 DEG C of temperature
It spends lower refluxing extraction three times, 4 hours every time, obtains extracting solution；
3) filtering and concentrating: by the filtering of step 2) resulting extracting solution and merging filtrate, using rotary evaporator to filtrate into
Row is concentrated by evaporation, and obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), with temperature after degreasing concentrate
The baking oven forced air drying that degree is 80 DEG C, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) is prepared into the Burdok root P.E aqueous solution of 0.01g/mL, it will
Macroreticular resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 25 DEG C of constant temperature, Static Adsorption are kept
2 hours, obtain the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, concentration is added
30% ethanol solution elution, elution speed 1.5BV/h collect eluent after elution, are concentrated and dried and mention for powdery radix bardanae
Take object；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed with the ratio of 1:4,
The as described radix bardanae extracting solution.
(5) extracting method of Spiraea ulmaria extract includes the following steps:
1) Hua Heye for choosing Spiraea ulmaria uses 60% ethanol solution of concentration as solvent, and Extracting temperature is 70 DEG C, extracts
Number is 2 times, and each extraction time is 2 hours, and each solvent usage is 10 times of Spiraea ulmaria weight, and filtering obtains first and mentions
Take liquid and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, filters, obtains the first medicine
Liquid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then uses concentration
80% ethanol solution elution, collects 80% concentration ethanol eluent, is concentrated and dried to get the first Spiraea ulmaria extract；
3) it by resulting first dregs of a decoction of step 1), uses 2.5% hydrochloric acid solution of concentration as solvent, 70 DEG C of Extracting temperature, mentions
Taking number is 2 times, and each extraction time is 2 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, is filtered, and merging mentions
Liquid is taken, relative density d=1.16 is concentrated into, with ammonium hydroxide tune pH to 10, is extracted with ethyl acetate 4 times, acetic acid ethyl acetate extract is used
After washing 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) is mixed
The even Spiraea ulmaria extract to get powdery.
(6) preparation of the composition of sebum secretion amount is adjusted:
When the temperature of blender is adjusted to 43 DEG C, 30g isoflavones, 36g are sequentially added into the mixing drum of blender
Barosma betulina leaf extract, 30g radix bardanae extracting solution and 4g Spiraea ulmaria extract are opened blender stirring, are evenly stirred until often
The composition of the tune section sebum secretion amount is made in temperature.
Two, the adjustment type milky lotion of 100g is prepared, by weight percentage, each raw material components accounts in the milky lotion
Than as follows:
Glycerol 5%, butanediol 5%, carbomer 0.4%, triethanolamine 0.5%, ceramide 0.1%, hydrolecithin
1.5%, dimethyl silicone polymer 5.5%, adjust smegma composition 10%, moutan root bark extracting solution 5%, deionization
Water 67%.
Three, the preparation method of adjustment type milky lotion
S01 ingredient: it is equipped with following raw material: 5% glycerol, 5% butanediol, 0.4% carbomer, 0.5% by weight percentage
Triethanolamine, 0.1% ceramide, 1.5% hydrolecithin, 5.5% dimethyl silicone polymer, 10% adjust smegma
Composition, 5% moutan root bark extracting solution and 67% deionized water；Wherein, the group of the composition for adjusting sebum secretion amount
As isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, institute
It states hydrolecithin, the dimethyl silicone polymer, sequentially add homogenizer, add the deionized water, be heated to 83 DEG C,
Heat preservation opened homogenizer after 12 minutes, makes its emulsification in uniform bright emulsion form, stops homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 43 DEG C, add the adjusting sebaceous glands
The composition of secretory volume and the moutan root bark extracting solution, homogeneous 3 minutes, are added the triethanolamine, are evenly stirred until room temperature,
Up to the adjustment type milky lotion.
Embodiment 4
One, the preparation of raw material
(1) moutan root bark extracting solution extracting method includes the following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 45 DEG C, takes out tree peony root later
Skin is simultaneously crushed to 40 mesh, spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnated
After 20 hours, after applying the ultrasonication 5min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) it filters: the resulting moutan root bark mixed extract of step 2) being transferred under conditions of temperature is 38 DEG C and is stood
It is filtered after 25min, gained filtrate is moutan root bark extracting solution.
(2) extracting method of isoflavones includes the following steps:
1) feedstock processing: being crushed to partial size in 0.7mm for soybean meal, spare；
2) solvent extraction: by the resulting soybean meal concentration of step 1) be 50% ethanol water extract, raw material with
The solid-liquid ratio of solvent is 1g:10mL, and Extracting temperature is 75 DEG C, extraction time 7h, and extraction time is 3 times, obtains extracting solution；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 6h of obtained extraction object；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the cutting point of ultrafiltration membrane with ultrafiltration membrane
Son amount be 80000, by the leaching liquor temperature of ultrafiltration membrane at 88 DEG C, then with adsorb resin adsorption leaching liquor in the different Huang of soybean
Ketone；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain powdery soybean
Isoflavones；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99
It closes, the as described isoflavones.
(3) Barosma betulina leaf extract is made through the method for microwave abstracting, and extractant used is butanediol aqueous solution, micro-
Wave frequency rate is 200000MHz.
(4) extracting method of radix bardanae extracting solution includes the following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:16mL, in 65 DEG C of temperature
It spends lower refluxing extraction three times, 4.2 hours every time, obtains extracting solution；
3) filtering and concentrating: by the filtering of step 2) resulting extracting solution and merging filtrate, using rotary evaporator to filtrate into
Row is concentrated by evaporation, and obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), with temperature after degreasing concentrate
The baking oven forced air drying that degree is 78 DEG C, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) is prepared into the Burdok root P.E aqueous solution of 0.01g/mL, it will
Macroreticular resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 28 DEG C of constant temperature, Static Adsorption are kept
3 hours, obtain the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, concentration is added
45% ethanol solution elution, elution speed 2BV/h collect eluent after elution, are concentrated and dried as the extraction of powdery radix bardanae
Object；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed with the ratio of 1:4,
The as described radix bardanae extracting solution.
(5) extracting method of Spiraea ulmaria extract includes the following steps:
1) Hua Heye for choosing Spiraea ulmaria uses 58% ethanol solution of concentration as solvent, and Extracting temperature is 68 DEG C, extracts
Number is 2 times, and each extraction time is 1.8 hours, and each solvent usage is 10 times of Spiraea ulmaria weight, and filtering obtains first
Extracting solution and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, filters, obtains first
Medical fluid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then uses concentration
77% ethanol solution elution, collects 77% concentration ethanol eluent, is concentrated and dried to get the first Spiraea ulmaria extract；
3) it by resulting first dregs of a decoction of step 1), uses 2.8% hydrochloric acid solution of concentration as solvent, 68 DEG C of Extracting temperature, mentions
Taking number is 2 times, and each extraction time is 1.8 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, is filtered, and is merged
Extracting solution is concentrated into relative density d=1.16, with ammonium hydroxide tune pH to 9, is extracted with ethyl acetate 4 times, and acetic acid ethyl acetate extract is used
After washing 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) is mixed
The even Spiraea ulmaria extract to get powdery.
(6) preparation of the composition of sebum secretion amount is adjusted:
When the temperature of blender is adjusted to 44 DEG C, 28g isoflavones, 31g are sequentially added into the mixing drum of blender
Barosma betulina leaf extract, 37.5g radix bardanae extracting solution and 3.5g Spiraea ulmaria extract are opened blender stirring, are stirred evenly
To room temperature, the composition of the tune section sebum secretion amount is made.
Two, the adjustment type milky lotion of 100g is prepared, by weight percentage, each raw material components accounts in the milky lotion
Than as follows:
Glycerol 4%, butanediol 4%, carbomer 0.5%, triethanolamine 0.35%, ceramide 0.15%, hydrogenation lecithin
Rouge 1%, dimethyl silicone polymer 5%, composition 8%, the moutan root bark extracting solution 3%, deionized water for adjusting smegma
74%.
Three, the preparation method of adjustment type milky lotion
S01 ingredient: it is equipped with following raw material: 4% glycerol, 4% butanediol, 0.5% carbomer, 0.35% by weight percentage
Triethanolamine, 0.15% ceramide, 1% hydrolecithin, 5% dimethyl silicone polymer, 8% adjust smegma group
Close object, 3% moutan root bark extracting solution and 74% deionized water；Wherein, the group of the composition for adjusting sebum secretion amount becomes
Isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, institute
It states hydrolecithin, the dimethyl silicone polymer, sequentially add homogenizer, add the deionized water, be heated to 84 DEG C,
Homogenizer is opened in heat preservation after ten minutes, is made its emulsification in uniform bright emulsion form, is stopped homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 42 DEG C, add the adjusting sebaceous glands
The composition of secretory volume and the moutan root bark extracting solution, homogeneous 4 minutes, are added the triethanolamine, are evenly stirred until room temperature,
Up to the adjustment type milky lotion.
Reference examples
The concrete composition of 1 reference examples 1-4 of table
Effete test embodiment
1, control sample is prepared in adjustment type milky lotion and reference examples 1-4 that embodiment 1-4 is prepared, used respectively
It is tested in trier, proves the effective of adjustment type milky lotion using the sebum level after preceding and use, moisture content change
Property.
Test method: women 8 of the age 22-25 years old of selection, are oiliness and Combination skin, without any skin disease and
Skin allergy history, everyone smears a kind of test sample, is applied to the identical position of face, test specimens cannot be used during test
Any cosmetics other than product；It is percutaneously flowed using the SebumScale sebum measuring instrument and VapoMeter of dilfin company, Finland
It loses moisture tester to be tested, selects the same position of face as test position；Before use, first testing the skin of trier respectively
Rouge content and moisture content；After use, the sebum level and moisture content of re-test trier, test result is as shown in table 2.
The test result of sebum and moisture of skin before and after 2 use of table
| Sebum level changes (%) | TWEL (is percutaneously lost moisture rate) | |
| Embodiment 1 | 3.4 | 2.3 |
| Embodiment 2 | 2.8 | 1.7 |
| Embodiment 3 | 5.1 | 1.9 |
| Embodiment 4 | 3.9 | 1.4 |
| Reference examples 1 | 10.7 | 6.3 |
| Reference examples 2 | 5.2 | 1.5 |
| Reference examples 3 | 6.9 | 2.1 |
| Reference examples 4 | 5.6 | 1.9 |
As can be seen from Table 2, the adjustment type milky lotion that 1-4 of the embodiment of the present invention is prepared has both oil-control and moisture-keeping function.And
By comparison it is found that adjust the composition of sebum secretion amount and moutan root bark extracting solution has association in terms of adjusting smegma
Same-action.
2, control sample is prepared in adjustment type milky lotion and reference examples 1-4 that embodiment 1-4 is prepared, used respectively
It is tested in trier, the validity of adjustment type milky lotion is proved using the pore varying aperture after preceding and use.
Test method: personnel 80 of selection age 22-35 years old, each half of masculinity femininity is oiliness and Combination flesh
Skin is divided into 8 groups without any skin disease and skin allergy history, and every group of 10 people, every group uses different test samples respectively, smears
At the identical position of face, any cosmetics cannot be used within test first 2 days, cannot be used other than test sample during test
Any cosmetics, subject clean face using test sample, once in the morning and once at night, use two months；
Skin pore aperture is tested using skin image analyzer, selects the same position of face as test position, respectively
Before and using measuring after two months, analysis obtains pore pore size, and test result is as shown in table 3.
Skin pore aperture (μ g/cm before and after 3 use of table2)
| Sample | Before use | After 2 months |
| Embodiment 1 | 187.6±21.1 | 163.2±18.3 |
| Embodiment 2 | 191.4±20.5 | 168.5±19.8 |
| Embodiment 3 | 193.1±19.7 | 170.8±18.7 |
| Embodiment 4 | 189.2±20.8 | 171.9±21.2 |
| Reference examples 1 | 191.7±21.6 | 192.4±20.4 |
| Reference examples 2 | 189.5±20.2 | 187.2±19.1 |
| Reference examples 3 | 189.1±19.5 | 180.1±18.9 |
| Reference examples 4 | 190.3±22.3 | 185.6±20.6 |
Seen from table 3, the adjustment type milky lotion that 1-4 of the embodiment of the present invention is prepared is imitated with preferable pore refining
Fruit.And by comparison it is found that moutan root bark extracting solution plays the role of that pore is promoted to shrink.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (9)
1. a kind of adjustment type milky lotion, which is characterized in that by weight percentage, be made of following raw material components:
Glycerol 3-5%, butanediol 3-5%, carbomer 0.15-0.5%, triethanolamine 0.15-0.5%, ceramide 0.1-
0.2%, hydrolecithin 0.5-2%, dimethyl silicone polymer 3-6%, the composition 5-10% for adjusting smegma, tree peony
Root skin extracting solution 1-5%, deionized water 67-84%；Wherein, it is different to become soybean for the group of the composition for adjusting sebum secretion amount
Flavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria extract.
2. adjustment type milky lotion according to claim 1, it is characterised in that: percentage, the adjusting sebum
The composition of the composition of secretory volume are as follows: the isoflavones 20-30%, the Barosma betulina leaf extract 25-40%, the ox
The burdock root extracting solution 30-45% and Spiraea ulmaria extract 3-4%.
3. adjustment type milky lotion according to claim 1, it is characterised in that: the moutan root bark extracting solution extracting method packet
Include following steps:
1) pretreatment of raw material: moutan root bark is placed in forced air drying in the baking oven that temperature is 40-60 DEG C, takes out moutan root bark later
And 40 mesh are crushed to, it is spare；
2) it extracts: the resulting moutan root bark powder of step 1) and ethylhexyl palmitate being mixed with the ratio of 1:4 and impregnate 12-24
After hour, after applying the ultrasonication 4-8min that frequency is 22kHz to mixed liquor, moutan root bark mixed extract is obtained；
3) it filters: the resulting moutan root bark mixed extract of step 2) being transferred under conditions of temperature is 30-40 DEG C and stands 20-
It is filtered after 40min, gained filtrate is moutan root bark extracting solution.
4. adjustment type milky lotion according to claim 1, it is characterised in that: the extracting method of the isoflavones includes
Following steps:
1) feedstock processing: being crushed to partial size in 0.5-0.8mm for soybean meal, spare；
2) solvent extraction: by the resulting soybean meal of step 1) with concentration be 40-80% ethanol water extract, raw material with it is molten
The solid-liquid ratio of agent is 1g:8-16mL, and Extracting temperature is 60-80 DEG C, extraction time 5-8h, and extraction time is 1-3 times, is mentioned
Take liquid；
3) it separates: after using centrifuge separation to the resulting extracting solution of step 2), by the dry 5-10h of obtained extraction object；
4) it refines: being combined using ultrafiltration membrane with absorption resin, remove partial impurities, the molecular weight cut off of ultrafiltration membrane with ultrafiltration membrane
For 600-100000, by the leaching liquor temperature of ultrafiltration membrane at 80-90 DEG C, then it is different with the soybean in absorption resin adsorption leaching liquor
Flavones；
5) it desorbs, is dry: after absorption resin adsorption, being desorbed with stripping liquid, be dried after desorption, obtain the different Huang of powdery soybean
Ketone；
6) dissolve: by powdery soybean isoflavones obtained by upper step, butanediol aqueous solution with 70% is mixed with the ratio of 1:99,
The as described isoflavones.
5. adjustment type milky lotion according to claim 1, it is characterised in that: the Barosma betulina leaf extract is through microwave abstracting
Method be made；Wherein, extractant used in the Barosma betulina leaf extract is butanediol aqueous solution, microwave frequency 400-
250000MHz。
6. adjustment type milky lotion according to claim 1, it is characterised in that: the extracting method packet of the radix bardanae extracting solution
Include following steps:
1) it crushes drying: taking radix bardanae pulverizing medicinal materials at 8 mesh, and kept dry；
2) ethyl alcohol extracts: by the resulting radix bardanae of step 1) and ethanol solution with the solid-liquid ratio of 1g:12-24mL, at 50-70 DEG C
At a temperature of refluxing extraction three times, it is 3.5-4.5 hours each, obtain extracting solution；
3) filtering and concentrating: the resulting extracting solution filtering of step 2) and merging filtrate steam filtrate using rotary evaporator
Hair concentration, obtains concentrate；
4) petroleum ether extraction: using petroleum ether to the resulting concentrate ungrease treatment of step 3), it is with temperature after degreasing concentrate
75-85 DEG C of baking oven forced air drying, obtains crude extract；
5) it isolates and purifies: the resulting crude extract of step 4) being prepared into the Burdok root P.E aqueous solution of 0.01g/mL, by macropore
Resin is placed in the Burdok root P.E aqueous solution, and is put into constant temperature oscillator, and 20-30 DEG C of constant temperature, Static Adsorption are kept
1-4 hours, obtain the Burdok root P.E of preliminary purification；Into the macroreticular resin for being adsorbed with Burdok root P.E, concentration is added
The ethanol solution of 15-60% elutes, and elution speed is 1.25-2.75 BV/h, collects eluent after elution, is concentrated and dried as powder
Shape Burdok root P.E；
6) by powdery Burdok root P.E obtained by upper step, butanediol aqueous solution with 75% is mixed, as with the ratio of 1:4
The radix bardanae extracting solution.
7. adjustment type milky lotion according to claim 1, it is characterised in that: the extracting method of the Spiraea ulmaria extract
Include the following steps:
1) Hua Heye for choosing Spiraea ulmaria uses concentration 55-65% ethanol solution as solvent, and Extracting temperature is 65-75 DEG C, mentions
Taking number is 2 times, and each extraction time is 1.5-2.5 hours, and each solvent usage is 10 times of Spiraea ulmaria weight, is filtered,
Obtain the first extracting solution and first dregs of a decoction；First extracting solution recycles ethyl alcohol, is concentrated into relative density d=1.12, filters, obtains
To the first medical fluid；
2) resulting first medical fluid of step 1) is first eluted with water by ADS-3 macroporous absorbent resin, then with concentration 75-85%
Ethanol solution elution, collect 75-85% concentration ethanol eluent, be concentrated and dried to get the first Spiraea ulmaria extract；
3) it by resulting first dregs of a decoction of step 1), uses concentration 2-3% hydrochloric acid solution as solvent, 65-75 DEG C of Extracting temperature, extracts
Number is 2 times, and each extraction time is 1.5-2.5 hours, and each solvent usage is 12 times of Spiraea ulmaria weight, is filtered, and is closed
And extracting solution, it is concentrated into relative density d=1.16, with ammonium hydroxide tune pH to 9-10, is extracted with ethyl acetate 4 times, ethyl acetate extraction
After taking liquid to be washed with water 3 times, ethyl acetate is recycled, is concentrated, it is dry, obtain the second Spiraea ulmaria extract；
4) the resulting first Spiraea ulmaria extract of step 2) and the resulting second Spiraea ulmaria extract of step 3) are mixed, i.e.,
Obtain the Spiraea ulmaria extract of powdery.
8. the preparation method of adjustment type milky lotion according to claim 1-7, it is characterised in that: including walking as follows
It is rapid:
S01 ingredient: with following raw material by weight percentage: 3-5% glycerol, 3-5% butanediol, 0.15-0.5% carbomer,
0.15-0.5% triethanolamine, 0.1-0.2% ceramide, 0.5-2% hydrolecithin, 3-6% dimethyl silicone polymer, 5-
10% adjusts composition, 1-5% moutan root bark extracting solution and the 67-84% deionized water of smegma；Wherein, the adjusting
The group of the composition of sebum secretion amount becomes isoflavones, Barosma betulina leaf extract, radix bardanae extracting solution, Spiraea ulmaria and extracts
Object；
S02 charging homogeneous: by the glycerol measured, the butanediol, the carbomer, the ceramide, the hydrogen
Change lecithin, the dimethyl silicone polymer, sequentially add homogenizer, adds the deionized water, be heated to 80-85 DEG C,
Heat preservation opened homogenizer after 8-15 minutes, makes its emulsification in uniform bright emulsion form, stops homogeneous；
S03 stirring: after homogeneous, agitating function is opened, is stirred and is cooled to 40-45 DEG C, add the adjusting sebaceous glands
The composition of secretory volume and the moutan root bark extracting solution, homogeneous 1-5 minutes, are added the triethanolamine, are evenly stirred until often
Temperature is to get the adjustment type milky lotion.
9. the preparation method of adjustment type milky lotion according to claim 8, it is characterised in that: the adjusting sebum secretion amount
The preparation of composition include the following steps:
S01: as needed, following raw material: isoflavones 20-30%, Barosma betulina leaf extract 25- is weighed respectively in proportion
40%, radix bardanae extracting solution 30-45% and Spiraea ulmaria extract 3-4%；
S02: when the temperature of blender is adjusted to 40-45 DEG C, sequentially added into the mixing drum of blender the isoflavones,
The Barosma betulina leaf extract, the radix bardanae extracting solution and the Spiraea ulmaria extract, open blender stirring, and stirring is equal
It is even to room temperature, the composition of the tune section sebum secretion amount is made.
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