CN110338792A - Ovarian epithelium malignant tumour detection device - Google Patents
Ovarian epithelium malignant tumour detection device Download PDFInfo
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- CN110338792A CN110338792A CN201910778153.1A CN201910778153A CN110338792A CN 110338792 A CN110338792 A CN 110338792A CN 201910778153 A CN201910778153 A CN 201910778153A CN 110338792 A CN110338792 A CN 110338792A
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- 230000002611 ovarian Effects 0.000 title claims abstract description 33
- 238000001514 detection method Methods 0.000 title claims abstract description 28
- 201000011510 cancer Diseases 0.000 title claims abstract description 23
- 210000000981 epithelium Anatomy 0.000 title claims abstract description 22
- 239000013307 optical fiber Substances 0.000 claims abstract description 29
- 230000010287 polarization Effects 0.000 claims abstract description 25
- 238000007334 copolymerization reaction Methods 0.000 claims abstract description 20
- 210000001672 ovary Anatomy 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 206010028980 Neoplasm Diseases 0.000 description 12
- 238000003745 diagnosis Methods 0.000 description 4
- 210000004881 tumor cell Anatomy 0.000 description 4
- 238000002604 ultrasonography Methods 0.000 description 4
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000013170 computed tomography imaging Methods 0.000 description 2
- 238000013399 early diagnosis Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000009849 Female Genital Neoplasms Diseases 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 208000011937 ovarian epithelial tumor Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
- A61B5/4318—Evaluation of the lower reproductive system
- A61B5/4325—Evaluation of the lower reproductive system of the uterine cavities, e.g. uterus, fallopian tubes, ovaries
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of ovarian epithelium malignant tumour detection device, which includes tunable THz source, the first optical fiber, polarization spectroscope, copolymerization focus lens, plano-convex lens, window, reflecting mirror, the second optical fiber, terahertz light spectrometer and computer;The light input end of first optical fiber is connect with the light output end of tunable THz source, and the light output end of first optical fiber and the light input end of polarization spectroscope connect;The light input end of second optical fiber and the light output end of reflecting mirror connect, and the light output end of second optical fiber is connect with the light input end of terahertz light spectrometer;The data output end of the terahertz light spectrometer is connected by the data input pin of cable and computer.Detection device of the invention is using tunable THz source as emission source, it is combined by multiple lens and THz wave is focused into Ovarian surface detects, low and without side-effects to human body, testing result accuracy height is required not only for the operating environment of detection.
Description
Technical field
The present invention relates to the technical fields of medical instrument, and in particular to a kind of ovarian epithelium malignant tumour detection device.
Background technique
Ovarian epithelium malignant tumour is common gynecological tumor disease, and early stage more non-evident symptons are mostly when clarifying a diagnosis
Advanced stage, case fatality rate are higher.The ovarian epithelium malignant tumour for detecting early stage is conducive to take correct treatment in time, reduces and suffers from
Person's case fatality rate.
Currently, the detection of detection method essential ultrasound, CT imaging and nuclear magnetic resonance to ovarian epithelium malignant tumour.Wherein,
Ultrasound diagnosis can determine the size, form and tumor location of Ovarian epithelial tumor, but can not sentence to the property of tumour
It is disconnected, and for the tumour of early stage small volume, ultrasound diagnosis can not differentiate;CT imaging certain to the progress of tumour property can be sentenced
It is disconnected, but the occurring source of CT is X-ray, and long-time service has certain side effect to human body;Nuclear magnetic resonance has lesion detection higher
Resolution ratio, but the operating time is longer, and must in certain circumstances using just can avoid interference of the metal to detection, detect at
This is higher.
Summary of the invention
It is an object of the invention to overcome the shortcomings of above-mentioned background technique, a kind of ovarian epithelium malignant tumour detection dress is provided
It sets, which, as emission source, is combined by multiple lens THz wave focusing to ovary using tunable THz source
Surface is detected, and requires low and without side-effects to human body, testing result accuracy not only for the operating environment of detection
It is high.
To achieve the above object, a kind of ovarian epithelium malignant tumour detection device provided by the invention, including it is tunable too
Hertz source, the first optical fiber, polarization spectroscope, copolymerization focus lens, plano-convex lens, window, reflecting mirror, the second optical fiber, terahertz light
Spectrometer and computer;
The light input end of first optical fiber is connect with the light output end of tunable THz source, the light of first optical fiber
The connection of the light input end of output end and polarization spectroscope;The light input end of second optical fiber and the light output end of reflecting mirror connect
It connects, the light output end of second optical fiber is connect with the light input end of terahertz light spectrometer;The data of the terahertz light spectrometer
Output end is connected by the data input pin of cable and computer;
The THz wave that the tunable THz source is launched successively is conducted through polarization spectro after passing through the first optical fiber
Mirror, copolymerization focus lens, plano-convex lens, window, the skin for then passing through patient focus to the surface of ovary;It is anti-via Ovarian surface
THz wave after penetrating successively conducts again reverses through window, plano-convex lens, copolymerization focus lens, is then passed through by polarization spectroscope
90 ° of refraction conduction are conducted after reflecting using reflecting mirror to terahertz light spectrometer to reflecting mirror;The terahertz light spectrometer will connect
The THz wave data received are conducted to computer, and the computer is used to carry out frequency domain and time domain to the data-signal received
Analysis.
Further, it further includes the first guide rail, and first guide rail is saturating along polarization spectroscope, copolymerization focus lens, plano-convex
The arranged direction extension of mirror, window;The polarization spectroscope is mounted on the first guide rail by first support, and the copolymerization is burnt thoroughly
Mirror is mounted on the first guide rail by second support, and the plano-convex lens are mounted on the first guide rail by third bracket, described
Window is mounted on the first guide rail by the 4th bracket.
Further, the bottom of the third bracket is provided with sliding block, and the sliding block is slided on the first guide rail with it
Dynamic connection.
Further, it further includes the second guide rail, and the reflecting mirror is mounted on the second guide rail by the 5th bracket.
Further, second guide rail is arranged vertically with the first guide rail.
Still further, the frequency range of the tunable THz source is 0.3~20THz.
Further, the frequency range of the tunable THz source is 1.5~10THz.
Compared with prior art, the present invention has the advantage that
First, the present invention using tunable THz source as detection source, the THz wave launched is between microwave and red
Between external wave, there is stronger penetrability and photon energy is small, have the characteristics that the radiation that unionized, penetrability are strong, to human body
Energy ratio X-ray is 1,000,000 times small, without side-effects to human body using THz wave detection ovarian epithelium malignant tumour, can accurately examine
Its size and location is surveyed, and carries out certain judgement to tumour property, is the early diagnosis and treatment of ovarian epithelium malignant tumour
Important references are provided.
Second, present invention design has polarization spectroscope, copolymerization focus lens, plano-convex lens and reflecting mirror to build Terahertz
The transmission line of wave, the orientable transmitting of THz wave, scanning resolution can tell the tumour of small volume up to micron order
Cell, conducive to the early detection of ovarian epithelium malignant tumour.In addition, THz wave can be directed through common clothing, using terahertz
Hereby wave, which is scanned pelvic cavity, implements easy to operate, suitable clinical quickly detection.
Third, the hot spot after THz wave focusing of the present invention is up to 100 microns, scanning resolution is swept better than common ultrasound
It retouches, and can directly exclude the signal interference between Ovarian surface and terahertz sources source using copolymerization focus lens, improve detection
Accuracy.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of ovarian epithelium malignant tumour detection device;
In figure: tunable THz source 1, the first optical fiber 2, polarization spectroscope 3, copolymerization focus lens 4, plano-convex lens 5, window
6, reflecting mirror 7, the second optical fiber 8, terahertz light spectrometer 9, computer 10, cable 11, the first guide rail 12, first support 13, second
Bracket 14, third bracket 15, the 4th bracket 16, sliding block 17, the second guide rail 18, the 5th bracket 19, skin 20, ovary 21.
Specific embodiment
Below with reference to the case study on implementation performance that the present invention will be described in detail, but they are not constituted to limit of the invention
It is fixed, it is only for example.Simultaneously by illustrating that advantages of the present invention will become clearer and be readily appreciated that.
A kind of ovarian epithelium malignant tumour detection device as shown in Figure 1, including tunable THz source 1, the first optical fiber
2, polarization spectroscope 3, copolymerization focus lens 4, plano-convex lens 5, window 6, reflecting mirror 7, the second optical fiber 8, terahertz light spectrometer 9 and
Computer 10;Tunable THz source 1 can launch THz wave, in this implementation, the manufacturer of tunable THz source 1
For RAINBOW PHOTONICS, model TeraTune, frequency is continuously adjusted in 0.3~20THz, and preferably frequency exists
It is continuously adjusted in 1.5~10THz.The manufacturer of polarization spectroscope 3 is THORLABS, model: VA5-1550.It is copolymerized focus lens
4 manufacturer is LENSTEK LASER OPTICS, model: CLS-F70;The manufacturer of plano-convex lens 5 is THORLABS,
Model: N-BK7;The manufacturer of window 6 is THORLABS, model: WG71050;The manufacturer of terahertz light spectrometer 9 is
THORLABS, model: TERA-ASOPS.The light input end of first optical fiber 2 is connect with the light output end of tunable THz source 1,
The light output end of first optical fiber 2 is connect with the light input end of polarization spectroscope 3;The light input end of second optical fiber 8 and reflecting mirror 7
Light output end connection, the light output end of the second optical fiber 8 are connect with the light input end of terahertz light spectrometer 9;Terahertz light spectrometer 9
Data output end is connect by cable 11 with the data input pin of computer 10;Be copolymerized focus lens 4 setting polarization spectroscope 3 with
Between plano-convex lens 5;Plano-convex lens 5 setting copolymerization focus lens 4 and window 6 between, polarization spectroscope 3, copolymerization focus lens 4,
Plano-convex lens 5, window 6 are located on same horizontal linear.
In above-mentioned technical proposal, it further includes the first guide rail 12 and the second guide rail 18, and the first guide rail 12 is along polarization spectroscope
3, it is copolymerized the arranged direction extension of focus lens 4, plano-convex lens 5, window 6;Polarization spectroscope 3 is mounted on the by first support 13
On one guide rail 12, copolymerization focus lens 4 are mounted on the first guide rail 12 by second support 14, and plano-convex lens 5 pass through third bracket
15 are mounted on the first guide rail 12, and window 6 is mounted on the first guide rail 12 by the 4th bracket 16.The bottom of third bracket 15 is set
It is equipped with sliding block 17, sliding block 17 is slidably connected on the first guide rail 12 with it.Reflecting mirror 7 is mounted on the by the 5th bracket 19
On two guide rails 18, the second guide rail 18 is arranged vertically with the first guide rail 12.
In above-mentioned technical proposal, the THz wave that tunable THz source 1 is launched after the first optical fiber 2 by successively conducting
By polarization spectroscope 3, copolymerization focus lens 4, plano-convex lens 5, window 6, the skin 20 for then passing through patient focuses to ovary 21
Surface;The THz wave original frequency for first adjusting tunable THz source 1, using the surface of the skin 20 of patient as window 6
Initial focus point, then adjust plano-convex lens 5 and slided along the first guide rail 12 until THz wave to be focused to the surface of ovary 21.Through
It is successively conducted again reverses through window 6, plano-convex lens 5, copolymerization focus lens 4, so by the THz wave after 21 surface reflection of ovary
It is conducted after being reflected using reflecting mirror 7 to terahertz light spectrometer by polarization spectroscope 3 by 90 ° of refraction conduction to reflecting mirror 7 afterwards
9;Subsequent point by point scanning covers entire Ovarian surface, completes a scan period;THz wave frequency is adjusted, next sweep is carried out
Retouch the period;Continuous tuning THz wave frequency makes each scan period generate the wideband reflection letter of corresponding 0.3~20THz frequency
Number.Terahertz light spectrometer 9 conducts the THz wave data received to computer 10, and computer 10 is used for the number received
It is believed that number progress frequency domain and time-domain analysis.By analyzing the time-domain signal reflected intensity and frequency-region signal characteristic peak of tumour cell,
Knub position, size and the property of real-time judge Ovarian surface.
Since Ovarian surface is located under skin about tens of milliseconds, THz wave between microwave and infrared waves, have compared with
Strong penetrability, for hot spot up to 100 microns, scanning resolution is better than common ultrasonic scanning after focusing;And it is burnt thoroughly using copolymerization
Mirror can directly exclude the signal interference between Ovarian surface and terahertz sources source.The tumour cell of Ovarian surface is thin compared to normal
Born of the same parents' accretion rate is accelerated, and cell density changes and intraor extracellular material exchange speed is accelerated, and has new vessels abundant point
Cloth is near tumor cells and inside.THz wave is very sensitive to polar molecule etc., can directly acquire with reactive material
The molecular fingerprint information of structure and properties.Therefore, it is reflected back the variation of THz wave intensity and phase by Ovarian surface, can divide
Normal Ovarian surface and tumor region are discerned, is to obtain the position and size that tumour cell generates by continuous scanning.In addition,
By the THz wave frequency-region signal difference of comparison benign tumour and malignant tumour reflection, the property of Ovarian surface tumour can determine whether
Matter provides reference early period for further pathologic diagnosis of tumor.Have no special requirements for the operating environment of detection and to human body without
Side effect can accurately detect its size and location especially when tumour forms early stage, i.e. small volume, and to tumour property into
The certain judgement of row, provides important references for the early diagnosis and treatment of ovarian epithelium malignant tumour.
More than, only a specific embodiment of the invention, it is noted that anyone skilled in the art is in this hair
In bright revealed technical scope, any changes or substitutions that can be easily thought of, should be covered by the protection scope of the present invention,
It is remaining unspecified for the prior art.
Claims (7)
1. a kind of ovarian epithelium malignant tumour detection device, it is characterised in that: including tunable THz source (1), the first optical fiber
(2), polarization spectroscope (3), copolymerization focus lens (4), plano-convex lens (5), window (6), reflecting mirror (7), the second optical fiber (8), too
Hertz spectrometer (9) and computer (10);
The light input end of first optical fiber (2) is connect with the light output end of tunable THz source (1), first optical fiber
(2) light output end is connect with the light input end of polarization spectroscope (3);The light input end and reflecting mirror of second optical fiber (8)
(7) light output end connection, the light output end of second optical fiber (8) are connect with the light input end of terahertz light spectrometer (9);Institute
The data output end for stating terahertz light spectrometer (9) is connect by cable (11) with the data input pin of computer (10);
The THz wave that the tunable THz source (1) is launched successively is conducted through polarization point after passing through the first optical fiber (2)
Light microscopic (3), copolymerization focus lens (4), plano-convex lens (5), window (6), the skin (20) for then passing through patient focus to ovary
(21) surface;It successively conducts again via the THz wave after ovary (21) surface reflection reverses through window (6), plano-convex lens
(5), focus lens (4) are copolymerized, are then conducted by 90 ° of refractions to reflecting mirror (7), using reflecting mirror by polarization spectroscope (3)
(7) it conducts after reflecting to terahertz light spectrometer (9);The terahertz light spectrometer (9) conducts the THz wave data received
To computer (10), the computer (10) is used to carry out frequency domain and time-domain analysis to the data-signal received.
2. ovarian epithelium malignant tumour detection device according to claim 1, it is characterised in that: it further includes the first guide rail
(12), first guide rail (12) along polarization spectroscope (3), copolymerization focus lens (4), plano-convex lens (5), window (6) arrangement
Direction extends;The polarization spectroscope (3) is mounted on the first guide rail (12) by first support (13), the copolymerization focus lens
(4) it is mounted on the first guide rail (12) by second support (14), the plano-convex lens (5) are mounted on by third bracket (15)
On first guide rail (12), the window (6) is mounted on the first guide rail (12) by the 4th bracket (16).
3. ovarian epithelium malignant tumour detection device according to claim 2, it is characterised in that: the third bracket (15)
Bottom be provided with sliding block (17), the sliding block (17) is slidably connected on the first guide rail (12) with it.
4. ovarian epithelium malignant tumour detection device according to claim 3, it is characterised in that: it further includes the second guide rail
(18), the reflecting mirror (7) is mounted on the second guide rail (18) by the 5th bracket (19).
5. ovarian epithelium malignant tumour detection device according to claim 4, it is characterised in that: second guide rail (18)
It is arranged vertically with the first guide rail (12).
6. ovarian epithelium malignant tumour detection device according to claim 1, it is characterised in that: the tunable Terahertz
The frequency range in source (1) is 0.3~20THz.
7. ovarian epithelium malignant tumour detection device according to claim 6, it is characterised in that: the tunable Terahertz
The frequency range in source (1) is 1.5~10THz.
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