CN110327417A - A kind of drug and preparation method thereof preventing and treating common eel bacillary enteritis - Google Patents
A kind of drug and preparation method thereof preventing and treating common eel bacillary enteritis Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
It is a kind of for preventing and treating the drug of common eel bacillary enteritis, specifically include following raw material and its component ratio: 10 ~ 15 parts of castor bean, 12 ~ 14 parts of rapeseed, 9 ~ 12 parts of soybean, 5 ~ 8 parts of chicken, 12 ~ 14 parts of brown sugar, 15 ~ 18 parts of garlic, 18 ~ 21 parts of radix bupleuri, 16 ~ 20 parts of cordate houttuynia, 20 ~ 23 parts of Radix Astragali, 18 ~ 24 parts of Rhizoma Atractylodis Macrocephalae.Preparation method are as follows: by castor bean, rapeseed, soybean material, crushed raw material respectively using pulverizer, smashed raw material is put into container;Chicken is rubbed using meat grinder;It mixes the above raw material and pours into blender and stir, in whipping process, brown sugar is added, medicament must be prevented after mixing evenly;It by garlic, radix bupleuri, cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae, crushes respectively, pours into blender and stir evenly, obtain medical treatment medicament;Prevention medicament and healing potion are stirred mixing, and are granulated by screw pelletizer to get drug is arrived.Drug Nantural non-toxic side effect of the invention, while not will cause water pollution, the bacillary enteritis of common eel can be prevented and treated, therapeutic efficiency is high.
Description
[technical field]
The invention belongs to propagate aquatic products disease prevention and cure technical field, in particular to a kind of bacillary intestines of prevention and treatment common eel artificially
Scorching drug and preparation method thereof.
[background technique]
Common eel is one of most important culturing economic fish of China.In recent years, as eel industry intensive degree is deepened, the environment side of body
Compel aggravation, the farming disease harms are on the rise, and cause huge economic loss to common eel aquaculture.Wherein, bacteriosis endangers
It is more serious.Mainly the chemicals based on broad-spectrum antibiotic (such as chloramphenicol, orfloxacin) are prevented and treated in production at present,
It is a large amount of using the deterioration for not only aggravating water environment although they have many advantages, such as that significant in efficacy, treatment cycle is short, improve disease
The drug resistance of opportunistic pathogen may also suppress common eel growth, the internal organs function such as damage common eel liver, it is often more important that, lead to drug
Residual in the product is exceeded, reduces product quality.In addition to this, it there are also other Prevention Techniques, is moved on to after fry sorts
When new pond, fishpond is embathed with 0.1% ~ 0.7% salt water, pond periodically sterilizes, and with 25 ~ 30 mg/litre formalin solutions or uses
0.1 ~ 0.2 mg/litre methyl blue is splashed pond, is prevented common eel disease;When disease occurs for common eel, morbidity pond water
Temperature is increased to 25 DEG C or more, is embathed with 2 ~ 3 mg/litre nitrofurazone, or is embathed with 0.1 ~ 0.2 mg/litre malachite green, to hair
The common eel of disease is treated.These Prevention Techniques, there are certain drawbacks: (1) common eel feed is reduced, and influences the life of common eel seedling
It is long, therapeutic effect can be made further to weaken, control efficiency is general;(2) treatment cost is big, time-consuming and laborious;(3) to breeding water amount
Demand is excessive, causes water resource waste, does not meet environmental requirement;(4) remaining drug after medication, easily causes the dirt of water body
Dye, is unfavorable for the protection of environment.
Therefore, reasonable development Medicines in Aquaculture has become the major issue of aquatic products disease research.Chinese herbal medicine class drug has day
Right property, trophism, enhancing immune function, resisting stress, antimicrobial, drive (killing) worm, bidirectional modulation, the secondary residual of poison is small, is not easy to produce
A variety of advantages such as raw drug resistance.So application of the Chinese herbal medicine class drug on fish disease prevention and cure is increasingly taken seriously.This drug by
Chinese herbal medicine is made with conventional Material Science proportion, can prevent and treat the bacillary enteritis of common eel, and therapeutic efficiency is high.
[summary of the invention]
The first technical problem to be solved by the present invention is to provide a kind of for preventing and treating the medicine of common eel bacillary enteritis
Object can prevent and treat the bacillary enteritis of sea eel.The drug Nantural non-toxic side effect, not will cause water pollution, and therapeutic efficiency is high.
The second technical problem to be solved by the present invention is to provide a kind of for preventing and treating common eel bacillary enteritis
Drug preparation method, this method is simple and effective, and the drug of preparation is naturally without side-effects, not will cause water pollution, can be with
The bacillary enteritis of sea eel is prevented and treated, therapeutic efficiency is high.
The present invention is implemented as follows:
It is a kind of for preventing and treating the drug of common eel bacillary enteritis, specifically include following raw material and its component ratio:
10 ~ 15 parts of castor bean, 12 ~ 14 parts of rapeseed, 9 ~ 12 parts of soybean, 5 ~ 8 parts of chicken, 12 ~ 14 parts of brown sugar, 15 ~ 18 parts of garlic,
18 ~ 21 parts of radix bupleuri, 16 ~ 20 parts of cordate houttuynia, 20 ~ 23 parts of Radix Astragali, 18 ~ 24 parts of Rhizoma Atractylodis Macrocephalae.
Further, the raw material and its component ratio are as follows:
12 parts of castor bean, 13 parts of rapeseed, 10 parts of soybean, 7 parts of chicken, 8 parts of brown sugar, 18 parts of garlic, 20 parts of radix bupleuri, cordate houttuynia 19
Part, 22 parts of Radix Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae.
It is a kind of for preventing and treating the preparation method of the drug of common eel bacillary enteritis, include the following steps:
Step S1: weighing castor bean, rapeseed, the soybean material of mass parts as claimed in claim 1 or 2, removes impurity, so
Raw material is crushed respectively using pulverizer afterwards, smashed raw material is put into container, spare;
Step S2: being weighed the chicken of mass parts as claimed in claim 1 or 2, rubbed using meat grinder, spare;
Step S3: the chicken after the smashed raw material of step S1 and step S2 are blended, which pours into blender, to be stirred, stirred
Cheng Zhong is added brown sugar, must prevent medicament after mixing evenly;
Step S4: garlic, radix bupleuri, the cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae of mass parts as claimed in claim 1 or 2 are weighed, respectively powder
It is broken, it pours into blender and stirs evenly, obtain medical treatment medicament;
Step S5: the obtained healing potion of the obtained prevention medicament of step S3 and step S4 is stirred mixing, and passes through spiral shell
Bar pelletizer is granulated to arrive drug.
Further, the application method for the drug that the step S5 is obtained are as follows: mix and feed with feed, wherein the drug with
The ratio of feed are as follows: 1:30 ~ 50.
The present invention has the advantages that the present invention provides a kind of for preventing and treating the drug of common eel bacillary enteritis,
The composition of drug is natural material, without other toxic side effects, not will cause water pollution.Drug ingedient is prevention medicament and controls
Treat medicament, prevent to contain more lipase in castor bean and rapeseed in medicament, to the treatment of common eel bacillary enteritis and
Prevention has good effect;While the feed of common eel can be stimulated in soybean, chicken rich in amino acid abundant, avoid common eel
The therapeutic effect caused by period of disease feed less is bad;Garlic, radix bupleuri, cordate houttuynia, Radix Astragali and Rhizoma Atractylodis Macrocephalae are natural traditional Chinese medicine
Material has the effect of sterilization, antibacterial, strengthen immunity.
[specific embodiment]
Embodiment one:
It is a kind of for preventing and treating the drug of common eel bacillary enteritis, specifically include following raw material and its component ratio:
12 parts of castor bean, 13 parts of rapeseed, 10 parts of soybean, 7 parts of chicken, 8 parts of brown sugar, 18 parts of garlic, 20 parts of radix bupleuri, cordate houttuynia 19
Part, 22 parts of Radix Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae.
Preparation method includes the following steps:
Step S1: weighing castor bean, rapeseed, the soybean material of mass parts as described above, removes impurity, then using crushing
Raw material is crushed respectively and is put into container by machine, spare;
Step S2: being weighed the chicken of mass parts as described above, rubbed using meat grinder, spare;
Step S3: the chicken after the smashed raw material of step S1 and step S2 are rubbed, which pours into blender, to be stirred, stirred
Cheng Zhong is added brown sugar, must prevent medicament after mixing evenly;
Step S4: garlic, radix bupleuri, the cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae of mass parts as described above are weighed, crushes respectively, pours into stirring
It is stirred evenly in device, obtain medical treatment medicament;
Step S5: the obtained healing potion of the obtained prevention medicament of step S3 and step S4 is stirred mixing, and passes through spiral shell
Bar pelletizer is granulated to arrive drug.
The application method of the drug are as follows: mix and feed with feed, wherein the ratio of drug and feed are as follows: 1:40.
Embodiment two:
It is a kind of for preventing and treating the drug of common eel bacillary enteritis, specifically include following raw material and its component ratio:
10 parts of castor bean, 12 parts of rapeseed, 12 parts of soybean, 8 parts of chicken, 12 parts of brown sugar, 15 parts of garlic, 18 parts of radix bupleuri, cordate houttuynia
20 parts, 23 parts of Radix Astragali, 24 parts of Rhizoma Atractylodis Macrocephalae.
Preparation method includes the following steps:
Step S1: weighing castor bean, rapeseed, the soybean material of mass parts as described above, removes impurity, then using crushing
Machine crushes raw material respectively, and smashed raw material is put into container, spare;
Step S2: being weighed the chicken of mass parts as described above, rubbed using meat grinder, spare;
Step S3: the chicken after the smashed raw material of step S1 and step S2 are rubbed, which pours into blender, to be stirred, stirred
Cheng Zhong is added brown sugar, must prevent medicament after mixing evenly;
Step S4: garlic, radix bupleuri, the cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae of mass parts as described above are weighed, crushes respectively, pours into stirring
It is stirred evenly in device, obtain medical treatment medicament;
Step S5: the obtained healing potion of the obtained prevention medicament of step S3 and step S4 is stirred mixing, and passes through spiral shell
Bar pelletizer is granulated to arrive drug.
The application method of the drug are as follows: mix and feed with feed, wherein the ratio of drug and feed are as follows: 1:30.
Embodiment three:
It is a kind of for preventing and treating the drug of common eel bacillary enteritis, specifically include following raw material and its component ratio:
15 parts of castor bean, 14 parts of rapeseed, 9 parts of soybean, 5 parts of chicken, 14 parts of brown sugar, 18 parts of garlic, 21 parts of radix bupleuri, cordate houttuynia 16
Part, 20 parts of Radix Astragali, 18 parts of Rhizoma Atractylodis Macrocephalae.
Preparation method includes the following steps:
Step S1: weighing castor bean, rapeseed, the soybean material of mass parts as described above, removes impurity, then using crushing
Machine crushes raw material respectively, and smashed raw material is put into container, spare;
Step S2: being weighed the chicken of mass parts as described above, rubbed using meat grinder, spare;
Step S3: the chicken after the smashed raw material of step S1 and step S2 are blended, which pours into blender, to be stirred, stirred
Cheng Zhong is added brown sugar, must prevent medicament after mixing evenly;
Step S4: garlic, radix bupleuri, the cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae of mass parts as described above are weighed, crushes respectively, pours into stirring
It is stirred evenly in device, obtain medical treatment medicament;
Step S5: the obtained healing potion of the obtained prevention medicament of step S3 and step S4 is stirred mixing, and passes through spiral shell
Bar pelletizer is granulated to arrive drug.
The application method of the drug are as follows: mix and feed with feed, wherein the ratio of drug and feed are as follows: 1:50.
The pharmacology situation of the Chinese medicine wherein used in prescription of the present invention are as follows: (1) radix bupleuri: for umbelliferae bupleurum or narrow
The dry root of leaf radix bupleuri, it is bitter in taste, slightly cold, return liver, gallbladder channel.There is the effect of Tongli inducing diaphoresis, soothing the liver rising Yang.For generating heat, fever and chills
Contact, malaria, stagnation of QI due to depression of the liver etc..(2) cordate houttuynia: for the dry aerial parts of saururaceae plant houttuynia cordata, acrid flavour is cold,
It is distributed in lung channel.Energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting are treated in detumescence, for controlling damp and hot, heat toxin, damp evil, disease
Heat is pulmonary abscess, sore swollen toxin, hemorrhoidal hemorrhage, the retention of heat in the spleen and stomach etc. suffered from.(3) Radix Astragali: for the root of leguminous mongolian scutellaria.Function
It cures mainly are as follows: invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis are promoted the production of body fluid.For deficiency of vital energy and acking in strength, the long disunion of the open sore part.(4) Rhizoma Atractylodis Macrocephalae: grey for composite family
Art category herbaceos perennial, medicinal function are fortune spleen medicine, and Wen Xinlie bitter in taste has the benefits of turbid eliminating dampness, change, analgesic.
Using drug mix fodder feeding common eel of the invention, it can effectively enhance common eel immunity.It is obtained through overtesting,
Using traditional disease prevention and cure method, common eel monthly increases weight 7 grams, and disease incidence reaches 7%, and uses drug mix fodder of the invention
Feeding common eel can monthly increase weight 19 grams, and disease incidence is reduced to 0.5%.For having suffered from the common eel of enteritis, using drug of the invention
Mix fodder feeding, cure rate reach 98%.Therefore, drug of the invention can effectively prevent the bacillary enteritis of common eel, enhance eel
Eel immunity is effectively facilitated common eel growth.
The foregoing is merely preferable implementation use-cases of the invention, are not intended to limit the scope of the present invention.It is all
Within the spirit and principles in the present invention, made any modification, equivalent replacement and improvement etc., should be included in of the invention
Within protection scope.
Claims (4)
1. a kind of for preventing and treating the drug of common eel bacillary enteritis, it is characterised in that: specifically include following raw material and its
Component ratio:
10 ~ 15 parts of castor bean, 12 ~ 14 parts of rapeseed, 9 ~ 12 parts of soybean, 5 ~ 8 parts of chicken, 12 ~ 14 parts of brown sugar, 15 ~ 18 parts of garlic,
18 ~ 21 parts of radix bupleuri, 16 ~ 20 parts of cordate houttuynia, 20 ~ 23 parts of Radix Astragali, 18 ~ 24 parts of Rhizoma Atractylodis Macrocephalae.
2. as described in claim 1 a kind of for preventing and treating the drug of common eel bacillary enteritis, it is characterised in that: described
Raw material and its component ratio are as follows:
12 parts of castor bean, 13 parts of rapeseed, 10 parts of soybean, 7 parts of chicken, 8 parts of brown sugar, 18 parts of garlic, 20 parts of radix bupleuri, cordate houttuynia 19
Part, 22 parts of Radix Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae.
3. a kind of for preventing and treating the preparation method of the drug of common eel bacillary enteritis, it is characterised in that: including walking as follows
It is rapid:
Step S1: weighing castor bean, rapeseed, the soybean material of mass parts as claimed in claim 1 or 2, removes impurity, so
Raw material is crushed respectively using pulverizer afterwards, smashed raw material is put into container, spare;
Step S2: being weighed the chicken of mass parts as claimed in claim 1 or 2, rubbed using meat grinder, spare;
Step S3: the chicken after the smashed raw material of step S1 and step S2 are rubbed, which pours into blender, to be stirred, stirred
Cheng Zhong is added brown sugar, must prevent medicament after mixing evenly;
Step S4: garlic, radix bupleuri, the cordate houttuynia, Radix Astragali, Rhizoma Atractylodis Macrocephalae of mass parts as claimed in claim 1 or 2 are weighed, respectively powder
It is broken, it pours into blender and stirs evenly, obtain medical treatment medicament;
Step S5: the obtained healing potion of the obtained prevention medicament of step S3 and step S4 is stirred mixing, and passes through spiral shell
Bar pelletizer is granulated to arrive drug.
4. it is as claimed in claim 3 a kind of for preventing and treating the preparation method of the drug of common eel bacillary enteritis, it is special
Sign is: the application method for the drug that the step S5 is obtained are as follows: mixes and feeds with feed, wherein the ratio of drug and feed
Are as follows: 1:30 ~ 50.
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CN201910671361.1A CN110327417A (en) | 2019-07-24 | 2019-07-24 | A kind of drug and preparation method thereof preventing and treating common eel bacillary enteritis |
PCT/CN2019/115496 WO2021012460A1 (en) | 2019-07-24 | 2019-11-05 | Medicine for preventing and treating bacterial enteritis of eels, and preparation method therefor |
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WO2021012460A1 (en) * | 2019-07-24 | 2021-01-28 | 集美大学 | Medicine for preventing and treating bacterial enteritis of eels, and preparation method therefor |
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CN101473891A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Chinese herbal medicine feed additive and preparation method thereof |
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CN101473891A (en) * | 2008-01-04 | 2009-07-08 | 北京因科瑞斯医药科技有限公司 | Chinese herbal medicine feed additive and preparation method thereof |
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WO2021012460A1 (en) * | 2019-07-24 | 2021-01-28 | 集美大学 | Medicine for preventing and treating bacterial enteritis of eels, and preparation method therefor |
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