CN110314275B - Degradable flexible medicine controlled release device - Google Patents
Degradable flexible medicine controlled release device Download PDFInfo
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- CN110314275B CN110314275B CN201910614685.1A CN201910614685A CN110314275B CN 110314275 B CN110314275 B CN 110314275B CN 201910614685 A CN201910614685 A CN 201910614685A CN 110314275 B CN110314275 B CN 110314275B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Abstract
The present disclosure relates to a degradable flexible drug controlled release device. The drug-carrying substrate and the sealing cover of the device form a plurality of drug-carrying cavities, and each drug-carrying cavity carries drug solution; the bearing substrate is used for bearing the corresponding circuit controlled release unit and is suspended in the drug solution in the drug carrying cavity to form a floating island structure; the circuit controlled-release units are used for controlling the release of the target medicine in the medicine carrying cavity according to the received electromagnetic waves, each circuit controlled-release unit comprises an energy receiving coil and a heating resistor, and the energy receiving coil is used for generating induction current through electromagnetic resonance when receiving the electromagnetic waves corresponding to the self resonance frequency; the heating resistor is used for heating under the action of the induced current, and the generated heat acts on the medicine solution so as to promote the release of the target medicine in the medicine solution. The device provided by the embodiment of the disclosure can control the staged release of the drug, has a wider release and diffusion range of the drug, and is degradable.
Description
Technical Field
The disclosure relates to the technical field of electronics, in particular to a degradable flexible drug controlled release device.
Background
With the continuous progress of science and technology, electronic devices are continuously developed, and the requirements on the electronic devices in the aspects of stable performance, service life, functional state and the like are continuously improved. Therefore, in the design and manufacture of electronic devices, the performance is pursued, and at the same time, the physical stability of the devices is pursued, which is one of the causes of serious pollution of electronic wastes at present. In a sense, the more stable the electronic device, the better, such as those used in electronic equipment such as cell phones. However, for some electronic devices to be implanted into the body of a living body, if the physical form of the electronic device is stable after the electronic device fails, the body of the living body to which the electronic device is implanted needs to be taken out by a secondary operation, which causes secondary damage to the living body (especially human beings). Especially, some electronic devices which do not need to be implanted for a long time, such as an electrical stimulation device in the nerve repair process, some drug sustained release devices for postoperative treatment, and the like, how to ensure that the electronic devices are well fitted with the internal tissues of a human body in the use stage and can be automatically degraded in the body after failure is very important, and the technical problem to be solved at present is urgently solved.
Disclosure of Invention
In view of the above, the present disclosure provides a degradable flexible drug controlled release device.
According to an aspect of the present disclosure, there is provided a degradable flexible controlled drug release device installed on an in vivo and/or in vivo body, the device comprising: a drug-carrying substrate, a plurality of bearing substrates, a plurality of circuit controlled-release units and a sealing cover,
the drug-carrying substrate and the sealing cover form a plurality of drug-carrying cavities, each drug-carrying cavity carries a drug solution, and the drug solution contains a target drug;
each bearing substrate is used for bearing a corresponding circuit controlled release unit and is suspended in the drug solution in the drug carrying cavity to form a floating island structure;
each circuit controlled release unit is used for controlling the release of the target drug in the drug-loading cavity according to the received electromagnetic wave, each circuit controlled release unit comprises an energy receiving coil and a heating resistor,
the energy receiving coil is used for generating induction current through electromagnetic resonance when receiving electromagnetic waves corresponding to self resonance frequency, and the induction current is used for supplying power to the circuit controlled release unit;
the heating resistor is used for receiving the induced current, generating heat under the action of the induced current and acting the generated heat on the medicine solution so as to promote the release of the target medicine in the medicine solution.
For the above device, in one possible implementation, each circuit controlled release unit further comprises a parasitic capacitor,
the parasitic capacitor is connected with the energy receiving coil in the circuit controlled-release unit and used for controlling the resonance frequency of the energy receiving coil for electromagnetic resonance.
With regard to the above apparatus, in one possible implementation manner, each circuit controlled release unit includes a first lead portion, a second lead portion and an insulating portion, the first lead portion is connected with the second lead portion,
the first lead portion is annular and constitutes the energy receiving coil;
the second lead part is in an extensible shape and forms the heating resistor;
the second lead part is provided with a lead branch, and the lead branch is positioned above or below the first lead part and has an overlapped part with the first lead part;
the insulation part is positioned between the lead branch and the overlapped lead overlapped with the lead branch in the first lead part, and realizes electric insulation between the lead branch and the overlapped lead;
the wire branch, the overlap wire, and the insulating portion constitute the parasitic capacitor.
With the above-described apparatus, in one possible implementation, the shape of the wires in the first wire portion and/or the second wire portion is a malleable shape,
wherein the malleable shape comprises: serpentine, S-shaped.
With respect to the above-described apparatus, in one possible implementation, the carrier substrate in each drug-loaded chamber is also used to carry the target drug.
For the above device, in a possible implementation manner, the drug solutions include a plurality of types, different drug solutions are disposed in different drug-loaded cavities, and the resonance frequencies of the energy receiving coils in the drug-loaded cavities in which the different drug solutions are disposed are different.
With the above apparatus, in one possible implementation, the resonance frequency of the energy receiving coil is within a suppression frequency range of the target tumor cell,
the energy receiving coil is also used for inhibiting the proliferation of the target tumor cells through electromagnetic resonance when receiving the electromagnetic waves corresponding to the self-resonance frequency.
With respect to the above-described device, in one possible implementation, the device is capable of degrading within the organism when the device is implanted within the organism.
With respect to the above-described device, in one possible implementation, the material of the device comprises a degradable material,
wherein the materials of the medicine carrying substrate, the bearing substrate and the sealing cover comprise flexible degradable materials, the flexible degradable materials comprise at least one of polylactic acid, polylactic acid-glycolic acid copolymer, polylactic acid-polytrimethylene carbonate copolymer, polyvinyl alcohol and fibroin,
the material of the circuit controlled release units comprises at least one of iron, magnesium, zinc and molybdenum,
the material of the insulating part comprises at least one of silicon dioxide and magnesium oxide.
For the above device, in a possible implementation manner, the carrying substrate comprises a substrate upper part and a substrate lower part, and the substrate upper part and the substrate lower part are used for clamping the circuit controlled release unit.
The degradable flexible controlled drug release device provided by the embodiment of the disclosure comprises: the drug-loaded substrate and the sealing cover form a plurality of drug-loaded cavities, each drug-loaded cavity is loaded with a drug solution, and the drug solution contains a target drug; each bearing substrate is used for bearing a corresponding circuit controlled release unit and is suspended in the drug solution in the drug carrying cavity to form a floating island structure; each circuit controlled-release unit is used for controlling the release of the target drug in the drug-loading cavity according to the received electromagnetic waves, and comprises an energy receiving coil and a heating resistor, wherein the energy receiving coil is used for generating induction current through electromagnetic resonance when receiving the electromagnetic waves corresponding to the self resonance frequency and supplying power to the circuit controlled-release unit by utilizing the induction current; the heating resistor is used for receiving the induced current, generating heat under the action of the induced current and applying the generated heat to the medicine solution so as to promote the release of the target medicine in the medicine solution. The electromagnetic waves with different frequencies can be emitted externally to control the staged release of the medicine so as to release different medicines at different stages, and the release of the medicine is promoted by heating so that the diffusion range of the medicine is wider and the effect on organisms is better. The device has high stability and reliability in the organism in the using process, and the medicine in the device can be degraded into small molecules harmless to the organism in the organism after the medicine is released, and can be discharged out of the body along with the metabolism of the organism without secondary operation of taking out the device, thereby not bringing additional trauma to the organism. The device has wide application range and can bear different medicines according to actual needs. And the device has simple structure and is beneficial to realizing large-scale and batch manufacturing.
Other features and aspects of the present disclosure will become apparent from the following detailed description of exemplary embodiments, which proceeds with reference to the accompanying drawings.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate exemplary embodiments, features, and aspects of the disclosure and, together with the description, serve to explain the principles of the disclosure.
Fig. 1 and 2 show schematic structural diagrams of a degradable flexible controlled drug release device according to an embodiment of the present disclosure.
Fig. 3 is a schematic structural view illustrating a cap of a degradable flexible controlled drug release device according to an embodiment of the present disclosure.
Fig. 4 shows a schematic structural view of a drug-loaded substrate of a degradable flexible drug controlled release device according to an embodiment of the present disclosure.
Fig. 5 shows a schematic view of controlled drug release of a degradable flexible controlled drug release device according to an embodiment of the present disclosure.
Fig. 6 shows a schematic structural diagram of a circuit controlled release unit of a degradable flexible drug controlled release device according to an embodiment of the present disclosure.
Fig. 7 shows a schematic structural diagram of a degradable flexible controlled drug release device according to an embodiment of the present disclosure.
Detailed Description
Various exemplary embodiments, features and aspects of the present disclosure will be described in detail below with reference to the accompanying drawings. In the drawings, like reference numbers can indicate functionally identical or similar elements. While the various aspects of the embodiments are presented in drawings, the drawings are not necessarily drawn to scale unless specifically indicated.
The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present disclosure. It will be understood by those skilled in the art that the present disclosure may be practiced without some of these specific details. In some instances, methods, means, elements and circuits that are well known to those skilled in the art have not been described in detail so as not to obscure the present disclosure.
Fig. 1 and 2 show schematic structural diagrams of a degradable flexible controlled drug release device according to an embodiment of the present disclosure. Fig. 3 is a schematic structural view illustrating a cap of a degradable flexible controlled drug release device according to an embodiment of the present disclosure. Fig. 4 shows a schematic structural view of a drug-loaded substrate of a degradable flexible drug controlled release device according to an embodiment of the present disclosure. Fig. 5 shows a schematic view of controlled drug release of a degradable flexible controlled drug release device according to an embodiment of the present disclosure. As shown in fig. 1 to 5, the apparatus is attached to a surface and/or a body of a living body, and includes: the drug-carrying substrate 2, a plurality of carrying substrates 3, a plurality of circuit controlled release units and a sealing cover 1.
The medicine carrying substrate 2 and the sealing cover 1 form a plurality of medicine carrying cavities 7, medicine solution is carried in each medicine carrying cavity 7, and the medicine solution contains target medicines. Each bearing substrate 3 is used for bearing a corresponding circuit controlled release unit, and is suspended in the drug solution in the drug-loading cavity 7 to form a floating island structure. Each circuit controlled release unit is used for controlling the release of the target medicine in the medicine carrying cavity according to the received electromagnetic waves, and each circuit controlled release unit comprises an energy receiving coil 4 and a heating resistor 5. As shown in fig. 5, the energy receiving coil 4 is used for generating an induced current through electromagnetic resonance when receiving an electromagnetic wave (transmitted by a transmitting device such as an external energy transmitting coil) corresponding to its own resonance frequency, and supplying power to the circuit controlled release unit using the induced current. The heating resistor 5 is used for receiving the induced current, generating heat under the action of the induced current, and applying the generated heat to the medicine solution to promote the release of the target medicine in the medicine solution.
In this embodiment, the content and composition of the target drug in the drug solution can be set as required. The device can be applied to organisms such as human bodies, animals and the like. For example, for a patient with a brain glioma, the device may be implanted into the brain of the patient and the target drug may be monatin, lomustine, temozolomide, nimustine, paclitaxel, etc., to treat the patient. The skilled in the art can set the target drug according to actual needs, and the present disclosure does not limit this.
In one possible implementation, the drug solution may include a plurality of types, different drug solutions are disposed in different drug-loaded cavities 7, and the resonance frequencies of the energy-receiving coils 4 in the drug-loaded cavities 7 in which the different drug solutions are disposed are different.
In this embodiment, it is assumed that the device includes 5 drug-carrying cavities (as shown in fig. 1), five different drug solutions can be placed in the drug-carrying cavities, and the energy receiving coil in each drug-carrying cavity is set to have different resonance frequencies, for example, the resonance frequency of the energy receiving coil at the center position is set to 60KHz, the resonance frequency of the energy receiving coil at the upper left corner is set to 120KHz, the resonance frequency of the energy receiving coil at the upper right corner is set to 180KHz, the resonance frequency of the energy receiving coil at the lower left corner is set to 240KHz, and the resonance frequency of the energy receiving coil at the lower right corner is set to 300 KHz. Electromagnetic waves with different frequencies are transmitted to the device according to the drug release requirements in different time periods, for example, the electromagnetic waves with the frequency of 60KHz are transmitted on the first implanted day, so that the energy receiving coil in the drug-carrying cavity at the central position resonates to generate induced current, the heating resistor in the drug-carrying cavity at the central position heats, and the generated heat acts on the drug solution in the drug-carrying cavity at the central position to promote the release of the drugs in the drug solution. And respectively emitting electromagnetic waves with corresponding frequencies at later time to release other medicines.
In this embodiment, the carrier substrate and the circuit controlled-release unit thereon are suspended in the drug solution to form a "floating island", and when the device is subjected to an external force, the carrier substrate and the circuit controlled-release unit are isolated from the external force to a great extent under the protection of the drug solution to realize strain isolation, so that even if the device is subjected to a large external force, the circuit controlled-release unit can maintain the original shape and function, thereby ensuring the stability and reliability of the device.
In this embodiment, the heating resistor not only can promote drug release during the heating process, but also can act on the affected part of the patient to treat the patient.
In the present embodiment, the power P generated by the heating resistor 5 is related to the resistance of the resistor and the magnitude of the induced current of the energy receiving coil 4, where P is I2And R is shown in the specification. Wherein P is exothermic electricityThe resistor 5 generates heat power, I is an induced current generated by the energy receiving coil 4, and R is a resistance value of the heating resistor 5. Where, R ═ ρ l/S, where ρ is the conductivity of the material from which the heating resistor 5 is made, l is the length of the resistance wire of the heating resistor 5, and S is the cross-sectional area of the corresponding resistance wire. The resistance value can be changed by adjusting the length and the cross-sectional area of the resistance wire, so that the heating power of the heating resistor can be adjusted according to the requirement.
In a possible implementation manner, each circuit controlled release unit further includes a parasitic capacitor 8, and the parasitic capacitor 8 is connected to the energy receiving coil 4 in the circuit controlled release unit and is used for controlling a resonant frequency of the energy receiving coil 4 for performing electromagnetic resonance.
The degradable flexible controlled drug release device provided by the embodiment of the disclosure comprises: the drug-loaded substrate and the sealing cover form a plurality of drug-loaded cavities, each drug-loaded cavity is loaded with a drug solution, and the drug solution contains a target drug; each bearing substrate is used for bearing a corresponding circuit controlled release unit and is suspended in the drug solution in the drug-carrying cavity; each circuit controlled-release unit is used for controlling the release of the target drug in the drug-loading cavity according to the received electromagnetic waves, and comprises an energy receiving coil and a heating resistor, wherein the energy receiving coil is used for generating induction current through electromagnetic resonance when receiving the electromagnetic waves corresponding to the self resonance frequency and supplying power to the circuit controlled-release unit by utilizing the induction current; the heating resistor is used for receiving the induced current, generating heat under the action of the induced current and applying the generated heat to the medicine solution so as to promote the release of the target medicine in the medicine solution. The electromagnetic waves with different frequencies can be emitted externally to control the staged release of the medicine so as to release different medicines at different stages, and the release of the medicine is promoted by heating so that the diffusion range of the medicine is wider and the effect on organisms is better. The device has high stability and reliability in the organism in the using process, and the medicine in the device can be degraded into small molecules harmless to the organism in the organism after the medicine is released, and can be discharged out of the body along with the metabolism of the organism without secondary operation of taking out the device, thereby not bringing additional trauma to the organism. The device has wide application range and can bear different medicines according to actual needs. And the device has simple structure and is beneficial to realizing large-scale and batch manufacturing.
Fig. 6 shows a schematic structural diagram of a circuit controlled release unit of a degradable flexible drug controlled release device according to an embodiment of the present disclosure. Fig. 7 shows a schematic structural diagram of a degradable flexible controlled drug release device according to an embodiment of the present disclosure. In one possible implementation manner, as shown in fig. 6 and 7, each circuit controlled release unit includes a first wire portion S1, a second wire portion S2 and an insulation portion 6, and the first wire portion S1 is connected to the second wire portion S2. The first lead portion S1 is annular and constitutes the energy-receiving coil 4. The second lead portion S2 is in a malleable shape and constitutes the heating resistor 5. The second wire portion S2 has a wire branch S2 ', and the wire branch S2' is located above or below the first wire portion S1 and overlaps the first wire portion S1. The insulating part 6 is located between the wire branch S2 ' and the overlap wire S1 ' overlapping the wire branch S2 ' in the first wire part S1, achieving electrical insulation between the wire branch S2 ' and the overlap wire S1 '. The lead branch S2 ', the overlap lead S1', and the insulating portion 6 constitute a parasitic capacitor 8.
By the method, the circuit controlled-release unit can be directly prepared by the etching technology without independently preparing a required parasitic capacitor, so that the processing process of the device is simplified, and the manufacturing difficulty of the device is reduced.
In this implementation, the malleable shape of the second wire portion S2 may include a serpentine shape, an S-shape, or other malleable shape, which may improve the tensile properties of the heat-generating resistor, and improve the reliability and stability of the heat-generating resistor. The loop shape of the first lead portion constituting the energy receiving coil may be a shape of a "loop", a circular loop, or the like. The shape of the heating resistor and the energy receiving coil can be set by those skilled in the art according to practical needs, and the present disclosure does not limit this.
In the present embodiment, the resonant frequency of the circuit under the action of the energy-receiving coil 4 is
Where f is the resonance frequency, L is the inductance of the energy receiving coil 4, and C is the capacitance of the parasitic capacitor 8. By adjusting the dimensional parameters of the energy receiving coil 4 and the heating resistor 5 and the insulation 6, the capacitance of the parasitic capacitor 8 can be adjusted to change the resonant frequency of the shuffler circuit. And the capacitance of the parasitic capacitor
Wherein epsilonrThe dielectric constant of the material used for the insulating portion 6. S0Is the overlapping area of the energy-receiving coil 4 and the heat-generating resistor 5, i.e., the effective area of the parasitic capacitor 8. d is the distance between the two electrodes of the parasitic capacitor 8, i.e., the thickness of the insulating portion 6 between the energy-receiving coil 4 and the heat-generating resistor 5. Those skilled in the art can adjust L and epsilon according to actual needsr、S0And d, adjusting to finally realize that the multiple groups of circuit controlled-release units work under the corresponding resonance frequency, thereby releasing different medicines in corresponding time periods.
In a possible implementation, a parasitic capacitor may be further separately provided in the circuit controlled release unit, which is not limited by the present disclosure.
In one possible implementation, as shown in fig. 6, the shape of the wires in the first wire portion S1 and/or the second wire portion S2 is a malleable shape. Wherein the malleable shape may include: serpentine, S-shaped.
In the implementation mode, the shape of the lead in the first lead part and the second lead part can be the shape of a single lead, the leads in the first lead part and the second lead part are arranged into an extensible shape, and when the lead is stressed, a powerful guarantee is provided for counteracting strain through changes such as rotation and the like of the leads, so that the purpose of protecting the leads is achieved, and the stability and the reliability of the whole device in the using process are improved. The shape of the wire can be set by those skilled in the art according to actual needs, and the present disclosure does not limit this.
In one possible implementation, the carrier substrate 3 in each drug-loaded cavity 7 is also used to carry the target drug.
In this implementation, the carrier substrate may carry a drug. The bearing substrate can also absorb the drug solution in the drug loading cavity, after the drug solution in the drug loading cavity is absorbed, the heating resistance generates heat to promote the release of the drug on the bearing substrate, meanwhile, the bearing substrate reduces the drug concentration on the bearing substrate due to drug diffusion, and a certain drug concentration gradient is formed due to higher drug concentration in the surrounding drug loading cavity, so that the bearing substrate is promoted to further absorb the drug in the drug loading cavity, and a forward drug release circulation is formed to promote the release of the drug.
In one possible implementation, the resonance frequency of the energy receiving coil 4 is within the range of the suppression frequency of the target tumor cells. The energy receiving coil 4 is also used for suppressing the proliferation of the target tumor cells by electromagnetic resonance when receiving the electromagnetic wave corresponding to the self-resonance frequency.
In this implementation, the growth and propagation of different tumor cells can be inhibited to some extent by the electromagnetic wave with a specific frequency, and the resonance frequency of the energy receiving coil 4 can be adjusted as required to inhibit the proliferation of tumor cells to some extent when the tumor cells resonate. For example, the resonance frequency is set in the range of 100KHz to 1 MHz. The resonance frequency can be set by one skilled in the art according to the actual inhibition needs of the tumor cells, and the present disclosure is not limited thereto.
In one possible implementation, as shown in fig. 2 and 7, the carrier substrate 3 may include a substrate upper portion and a substrate lower portion, and the substrate upper portion and the substrate lower portion are used for clamping the controlled release unit of the circuit.
In this implementation manner, the carrier substrate may carry the controlled circuit release unit by way of clamping, and may also carry the controlled circuit release unit by way of wrapping, and the disclosure is not limited thereto.
In one possible implementation, the device is capable of degrading within the organism when the device is implanted within the organism.
In one possible implementation, the material of the device may comprise a degradable material. The materials of the drug-loaded substrate, the bearing substrate and the sealing cover can comprise flexible degradable materials, and the flexible degradable materials comprise at least one of polylactic acid (PLA), polylactic-co-glycolic acid (PLGA), polylactic acid-polytrimethylene carbonate copolymer (PLA-PTMC), polyvinyl alcohol (PVA) and fibroin. The material of the plurality of circuit controlled-release units may include at least one of iron, magnesium, zinc, and molybdenum. The material of the insulating portion may include at least one of silicon dioxide and magnesium oxide.
In this implementation, the materials and dimensions of the various components of the device may be selected based on the length of time the device is required to maintain a stable operating state in the living being, and are not limited by the present disclosure. For example, assuming that the device needs to be implanted and placed in a human body for 3 months to ensure normal release of the drug, PLA-PTMC can be selected as the material of the drug-carrying substrate, the carrier substrate and the cap, metal zinc is the material of the circuit controlled-release unit, and magnesium oxide is the material of the insulating part, and the sizes are set accordingly.
In one possible implementation, the device may have a thickness of 1mm to 2mm, a length of 10mm to 30mm, and a width of 10mm to 30 mm. The size of the device may be set according to information of a specific use scenario, such as degradation time requirement, amount of drug solution, a site where a living body is implanted, etc., which is not limited by the present disclosure.
In one possible implementation, the device may be provided in any shape, such as a petal shape, and the disclosure is not limited thereto.
The present disclosure also provides a method for preparing a part of the above device, which can firstly adopt the processes of depositing films and photoetching for multiple times on a hard substrate to prepare and finish the energy receiving coil 4, the insulating part 6 and the heating resistor 5 to obtain a circuit controlled release unit, and then transfer the circuit controlled release unit onto the bearing substrate 3 through a transfer printing technology. In the process of preparing the bearing substrate, the solution before curing of PLA-PTMC (the preparation material of the bearing substrate) and the corresponding target drug can be mixed and dissolved, and then the mixed liquid is cured, so that the bearing substrate with the target drug is formed.
It should be noted that, although the degradable flexible controlled drug release device is described above by taking the above embodiments as examples, those skilled in the art will understand that the disclosure should not be limited thereto. In fact, the user can flexibly set each component according to personal preference and/or actual application scene, as long as the technical scheme of the disclosure is met.
Having described embodiments of the present disclosure, the foregoing description is intended to be exemplary, not exhaustive, and not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The terms used herein were chosen in order to best explain the principles of the embodiments, the practical application, or technical improvements to the techniques in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.
Claims (10)
1. A degradable flexible controlled drug delivery device for installation on or in a body surface of an organism, the device comprising: a drug-carrying substrate, a plurality of bearing substrates, a plurality of circuit controlled-release units and a sealing cover,
the drug-carrying substrate and the sealing cover form a plurality of drug-carrying cavities, each drug-carrying cavity carries a drug solution, and the drug solution contains a target drug;
each bearing substrate is used for bearing a corresponding circuit controlled release unit and is suspended in the drug solution in the drug carrying cavity to form a floating island structure;
each circuit controlled release unit is used for controlling the release of the target drug in the drug-loading cavity according to the received electromagnetic wave, each circuit controlled release unit comprises an energy receiving coil and a heating resistor,
the energy receiving coil is used for generating induction current through electromagnetic resonance when receiving electromagnetic waves corresponding to self resonance frequency, and the induction current is used for supplying power to the circuit controlled release unit;
the heating resistor is used for receiving the induced current, generating heat under the action of the induced current and acting the generated heat on the medicine solution so as to promote the release of the target medicine in the medicine solution.
2. The apparatus of claim 1, wherein each circuit controlled release unit further comprises a parasitic capacitor,
the parasitic capacitor is connected with the energy receiving coil in the circuit controlled-release unit and used for controlling the resonance frequency of the energy receiving coil for electromagnetic resonance.
3. The apparatus of claim 2, wherein each circuit controlled release unit includes a first wire part, a second wire part, and an insulating part, the first wire part being connected with the second wire part,
the first lead portion is annular and constitutes the energy receiving coil;
the second lead part is in an extensible shape and forms the heating resistor;
the second lead part is provided with a lead branch, and the lead branch is positioned above or below the first lead part and has an overlapped part with the first lead part;
the insulation part is positioned between the lead branch and the overlapped lead overlapped with the lead branch in the first lead part, and realizes electric insulation between the lead branch and the overlapped lead;
the wire branch, the overlap wire, and the insulating portion constitute the parasitic capacitor.
4. The device of claim 3, wherein the shape of the wires in the first wire portion and/or the second wire portion is a malleable shape,
wherein the malleable shape comprises: and (4) S-shaped.
5. The device of claim 1, wherein the carrier substrate in each drug-loaded chamber is further configured to carry the targeted drug.
6. The device of claim 1, wherein the drug solution comprises a plurality of drug solutions, wherein different drug solutions are disposed in different drug-loaded chambers, and wherein the resonant frequencies of the energy-receiving coils in the drug-loaded chambers in which the different drug solutions are disposed are different.
7. The apparatus of claim 1, wherein the resonance frequency of the energy receiving coil is within a suppression frequency range of a target tumor cell,
the energy receiving coil is also used for inhibiting the proliferation of the target tumor cells through electromagnetic resonance when receiving the electromagnetic waves corresponding to the self-resonance frequency.
8. The device of claim 1, wherein the device is capable of degrading within the body of the organism when the device is implanted within the body of the organism.
9. The device of claim 3, wherein the device material comprises a degradable material,
wherein the materials of the medicine carrying substrate, the bearing substrate and the sealing cover comprise flexible degradable materials, the flexible degradable materials comprise at least one of polylactic acid, polylactic acid-glycolic acid copolymer, polylactic acid-polytrimethylene carbonate copolymer, polyvinyl alcohol and fibroin,
the material of the circuit controlled release units comprises at least one of iron, magnesium, zinc and molybdenum,
the material of the insulating part comprises at least one of silicon dioxide and magnesium oxide.
10. The apparatus of claim 1, wherein the carrier substrate comprises a substrate upper portion and a substrate lower portion, the substrate upper portion and the substrate lower portion being configured to hold the controlled release unit for the circuit.
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| CN1899644B (en) * | 1998-09-29 | 2012-12-12 | 沙斯公司 | Methods and apparatus for improved administration of pharmaceutically active compounds |
| CN100382860C (en) * | 2005-08-26 | 2008-04-23 | 东南大学 | Magnetic thermal synergetic electric aid transdermal medicine administration device |
| CN202699847U (en) * | 2012-06-13 | 2013-01-30 | 复旦大学 | Implant type thermochemotherapy device |
| CN105326638A (en) * | 2015-10-26 | 2016-02-17 | 华南理工大学 | Low-power-consumption wearable electromagnetic ultrasonic medicinal moxibustion device |
| WO2018004191A1 (en) * | 2016-06-29 | 2018-01-04 | 서울대학교 산학협력단 | Biosensing device and drug delivery device |
| KR101847984B1 (en) * | 2016-07-25 | 2018-04-11 | 서울대학교산학협력단 | Drug delivery device |
| KR101887282B1 (en) * | 2016-12-07 | 2018-08-09 | 서울대학교산학협력단 | Bioheater |
| CN107929926B (en) * | 2017-12-14 | 2020-05-19 | 清华大学 | Implantable degradable medicine slow-release electronic patch system |
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