CN110272209A - 掺硼生物活性玻璃微球及其制备方法与应用 - Google Patents
掺硼生物活性玻璃微球及其制备方法与应用 Download PDFInfo
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- CN110272209A CN110272209A CN201910371075.3A CN201910371075A CN110272209A CN 110272209 A CN110272209 A CN 110272209A CN 201910371075 A CN201910371075 A CN 201910371075A CN 110272209 A CN110272209 A CN 110272209A
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- boron
- bioactivity glass
- doping
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- 239000011521 glass Substances 0.000 title claims abstract description 178
- 238000002360 preparation method Methods 0.000 title claims abstract description 54
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims abstract description 36
- 229910052796 boron Inorganic materials 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 28
- 238000001556 precipitation Methods 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims description 38
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 235000019441 ethanol Nutrition 0.000 claims description 18
- 239000011259 mixed solution Substances 0.000 claims description 14
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 11
- 229910052710 silicon Inorganic materials 0.000 claims description 11
- 239000010703 silicon Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical group CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 claims description 7
- JRBPAEWTRLWTQC-UHFFFAOYSA-N dodecylamine Chemical group CCCCCCCCCCCCN JRBPAEWTRLWTQC-UHFFFAOYSA-N 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 7
- 229910052698 phosphorus Inorganic materials 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 7
- LGQXXHMEBUOXRP-UHFFFAOYSA-N tributyl borate Chemical group CCCCOB(OCCCC)OCCCC LGQXXHMEBUOXRP-UHFFFAOYSA-N 0.000 claims description 7
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical group CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 claims description 7
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 6
- 239000011574 phosphorus Substances 0.000 claims description 6
- 238000005245 sintering Methods 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- ZCCIPPOKBCJFDN-UHFFFAOYSA-N calcium nitrate Chemical group [Ca+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ZCCIPPOKBCJFDN-UHFFFAOYSA-N 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 230000036039 immunity Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000004005 microsphere Substances 0.000 abstract description 14
- 238000003980 solgel method Methods 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 55
- 238000010183 spectrum analysis Methods 0.000 description 13
- 150000002500 ions Chemical class 0.000 description 11
- 239000000843 powder Substances 0.000 description 11
- 239000002243 precursor Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 9
- 239000013049 sediment Substances 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- ZHJGWYRLJUCMRT-UHFFFAOYSA-N 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide Chemical compound C=1C=CC=C(C(F)(F)F)C=1C(C)OC(=C(S1)C(N)=O)C=C1N(C1=C2)C=NC1=CC=C2CN1CCN(C)CC1 ZHJGWYRLJUCMRT-UHFFFAOYSA-N 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 229910018557 Si O Inorganic materials 0.000 description 4
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 238000010408 sweeping Methods 0.000 description 3
- 239000005313 bioactive glass Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000005368 silicate glass Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 102000014128 RANK Ligand Human genes 0.000 description 1
- 108010025832 RANK Ligand Proteins 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C12/00—Powdered glass; Bead compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Geochemistry & Mineralogy (AREA)
- Ceramic Engineering (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Glass Compositions (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910371075.3A CN110272209A (zh) | 2019-05-06 | 2019-05-06 | 掺硼生物活性玻璃微球及其制备方法与应用 |
PCT/CN2019/124797 WO2020224261A1 (zh) | 2019-05-06 | 2019-12-12 | 掺硼生物活性玻璃微球及其制备方法与应用 |
Applications Claiming Priority (1)
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CN201910371075.3A CN110272209A (zh) | 2019-05-06 | 2019-05-06 | 掺硼生物活性玻璃微球及其制备方法与应用 |
Publications (1)
Publication Number | Publication Date |
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CN110272209A true CN110272209A (zh) | 2019-09-24 |
Family
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Family Applications (1)
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CN201910371075.3A Pending CN110272209A (zh) | 2019-05-06 | 2019-05-06 | 掺硼生物活性玻璃微球及其制备方法与应用 |
Country Status (2)
Country | Link |
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CN (1) | CN110272209A (zh) |
WO (1) | WO2020224261A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111268916A (zh) * | 2020-03-18 | 2020-06-12 | 四川大学 | 一种硒掺杂硅钙磷生物活性介孔玻璃粉末制备方法 |
WO2020224261A1 (zh) * | 2019-05-06 | 2020-11-12 | 深圳先进技术研究院 | 掺硼生物活性玻璃微球及其制备方法与应用 |
CN114084898A (zh) * | 2021-12-06 | 2022-02-25 | 景德镇陶瓷大学 | 一种耐高温、不团聚的超细γ-Ce2S3红色色料的制备方法及其制得的产品 |
WO2022120768A1 (zh) * | 2020-12-10 | 2022-06-16 | 深圳先进技术研究院 | 一种硼硅酸盐生物活性玻璃微纳米颗粒及制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080066495A1 (en) * | 2006-09-20 | 2008-03-20 | Inion Oy | Bioactive glass compositions |
CN102557398A (zh) * | 2011-12-31 | 2012-07-11 | 武汉大学 | 一种含硼纳米介孔大孔生物活性玻璃、其制备方法及应用 |
CN108892145A (zh) * | 2018-07-17 | 2018-11-27 | 佛山今兰生物科技有限公司 | 一种SiO2基生物活性组织修复材料的量化生产方法 |
CN109336371A (zh) * | 2018-09-03 | 2019-02-15 | 中国科学院深圳先进技术研究院 | 微纳米硼硅酸盐生物活性玻璃的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1250494A (en) * | 1984-03-01 | 1989-02-28 | Chhattar S. Kucheria | Bonding of bioactive glass coatings |
CN103143057B (zh) * | 2011-12-06 | 2014-09-17 | 中国科学院上海微***与信息技术研究所 | 石墨烯/生物活性干凝胶及其制备方法与应用 |
EP2969985A4 (en) * | 2013-03-14 | 2017-01-11 | Novabone Products, LLC | Compositions and methods for manufacturing sol-gel derived bioactive borophosphate glasses for medical applicatons |
CN110272209A (zh) * | 2019-05-06 | 2019-09-24 | 深圳先进技术研究院 | 掺硼生物活性玻璃微球及其制备方法与应用 |
-
2019
- 2019-05-06 CN CN201910371075.3A patent/CN110272209A/zh active Pending
- 2019-12-12 WO PCT/CN2019/124797 patent/WO2020224261A1/zh active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080066495A1 (en) * | 2006-09-20 | 2008-03-20 | Inion Oy | Bioactive glass compositions |
CN102557398A (zh) * | 2011-12-31 | 2012-07-11 | 武汉大学 | 一种含硼纳米介孔大孔生物活性玻璃、其制备方法及应用 |
CN108892145A (zh) * | 2018-07-17 | 2018-11-27 | 佛山今兰生物科技有限公司 | 一种SiO2基生物活性组织修复材料的量化生产方法 |
CN109336371A (zh) * | 2018-09-03 | 2019-02-15 | 中国科学院深圳先进技术研究院 | 微纳米硼硅酸盐生物活性玻璃的制备方法 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020224261A1 (zh) * | 2019-05-06 | 2020-11-12 | 深圳先进技术研究院 | 掺硼生物活性玻璃微球及其制备方法与应用 |
CN111268916A (zh) * | 2020-03-18 | 2020-06-12 | 四川大学 | 一种硒掺杂硅钙磷生物活性介孔玻璃粉末制备方法 |
WO2022120768A1 (zh) * | 2020-12-10 | 2022-06-16 | 深圳先进技术研究院 | 一种硼硅酸盐生物活性玻璃微纳米颗粒及制备方法和应用 |
CN114084898A (zh) * | 2021-12-06 | 2022-02-25 | 景德镇陶瓷大学 | 一种耐高温、不团聚的超细γ-Ce2S3红色色料的制备方法及其制得的产品 |
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Publication number | Publication date |
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WO2020224261A1 (zh) | 2020-11-12 |
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Inventor after: Pan Haobo Inventor after: Wang Yudong Inventor after: Cui Xu Inventor before: Wang Yudong Inventor before: Pan Haobo Inventor before: Cui Xu |
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Effective date of registration: 20200715 Address after: Room office building No. 1068 Shenzhen Institute of advanced technology A-301 518055 in Guangdong city of Shenzhen province Nanshan District Shenzhen University city academy Avenue Applicant after: Shenzhen shen-tech advanced Cci Capital Ltd. Address before: 1068 No. 518055 Guangdong city in Shenzhen Province, Nanshan District City Xili University School Avenue Applicant before: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY Effective date of registration: 20200715 Address after: No.301, No.23, Xihuan North Road, Buxin community, Dapeng street, Dapeng New District, Shenzhen City, Guangdong Province Applicant after: SHENZHEN ZHONGKE HEALTHEMES BIOTECHNOLOGY Co.,Ltd. Address before: Room office building No. 1068 Shenzhen Institute of advanced technology A-301 518055 in Guangdong city of Shenzhen province Nanshan District Shenzhen University city academy Avenue Applicant before: Shenzhen shen-tech advanced Cci Capital Ltd. |
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