CN110260974A - Microscopic Raman detecting devices - Google Patents
Microscopic Raman detecting devices Download PDFInfo
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- CN110260974A CN110260974A CN201910639345.4A CN201910639345A CN110260974A CN 110260974 A CN110260974 A CN 110260974A CN 201910639345 A CN201910639345 A CN 201910639345A CN 110260974 A CN110260974 A CN 110260974A
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- 238000001069 Raman spectroscopy Methods 0.000 title claims abstract description 41
- 230000003287 optical effect Effects 0.000 claims abstract description 97
- 230000007246 mechanism Effects 0.000 claims abstract description 20
- 238000005286 illumination Methods 0.000 claims abstract description 13
- 238000004458 analytical method Methods 0.000 claims abstract description 7
- 208000033748 Device issues Diseases 0.000 claims abstract description 3
- 239000013307 optical fiber Substances 0.000 claims description 21
- 239000000835 fiber Substances 0.000 claims description 19
- 230000010287 polarization Effects 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 abstract description 36
- 238000000034 method Methods 0.000 abstract description 4
- 230000035945 sensitivity Effects 0.000 description 5
- 230000003595 spectral effect Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 230000013011 mating Effects 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000001237 Raman spectrum Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000000399 optical microscopy Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/12—Generating the spectrum; Monochromators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/2823—Imaging spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to optical-mechanical technical field more particularly to a kind of microscopic Raman detecting devices.The equipment includes: export agency, the first optical filter, switching device, the second optical filter and introducing mechanism；The laser signal that laser is launched is irradiated on the first optical filter by export agency, the laser signal that first optical filter can launch laser is reflected into sample upper surface, the reflection signal that sample surfaces are inspired enters in introducing mechanism after the first optical filter, switching device and the second optical filter, and is imported into spectrograph by introducing mechanism and carry out Raman analysis；Observation device is located above switching device, switching device receives the illumination light that observation device issues, the illumination light that first optical filter can reflect switching device is reflected into the surface of sample, by sample surface reflection illumination light through the first optical filter, be reflected into observation device by switching device.To solve Raman probe described in background technique.
Description
Technical field
The present invention relates to optical-mechanical technical fields, in particular to a kind of microscopic Raman detecting devices.
Background technique
It is well known that micro Raman spectra measuring technique is that the micro scale experiment to grow up in recent years measures new skill
Art.The technology can pass through acquisition Raman scattering signal and analyze chemical component, crystal phase and stress that its spectrum obtains material
Or the information such as strain, it is widely used in the experimental analysis of numerous areas.Micro Raman spectra system is mature business
Melt the spectral measurement system of hair and application.These systems usually can have excellent spectrographic detection performance, such as high spatial point
Resolution, Gao Laman signal-to-noise ratio etc., have taken in the application study in the fields such as analytical chemistry, cell biology, materials physics
Obtain a series of success achievements.
On this basis, it is contemplated that these systems often structure fix, accurate and environmental requirement it is high, it is difficult to be same as engineering
Scene and with the spectrographic detection under environmental load.Some producers and scholar successfully have developed a variety of contacts or contactless
Raman detection probe, freedom degree and flexibility ratio with higher, to realize complex environment, scene or material and organization internal
Raman detection.However, existing Raman probe does not often have micro- real-time observing capacity, and usually poor sensitivity, light
Spectral resolution and spatial resolution are all very low, are unable to satisfy suitable to spatial discrimination, spectrally resolved and sensitivity and environmental load
Higher forward position experimental study is required to property.
Summary of the invention
The purpose of the present invention is to provide a kind of microscopic Raman detecting devices, are visited with solving Raman existing in the prior art
Head does not often have micro- real-time observing capacity, and usually poor sensitivity, the spectral resolution technology low with spatial resolution
Problem.
The embodiment of the present invention is achieved in that
One kind be used for microscopic Raman detecting devices, comprising: export agency and successively every the first optical filter of setting, switching dress
It sets, the second optical filter and introducing mechanism；
First optical filter is equipped with sample to be tested, the side of first optical filter far from the side of the switching device
Equipped with laser, the export agency is located between the laser and first optical filter, the side of the switching device
Equipped with observation device, the laser signal that the laser is launched is irradiated to first optical filter by the export agency
On, the laser signal that first optical filter can launch laser is reflected into the sample upper surface, the sample table
The reflection signal that face is inspired enters the importing machine after first optical filter, switching device and the second optical filter
In structure, and it is imported into the spectrograph by the introducing mechanism and carries out Raman analysis；
The observation device is located above the switching device, and the switching device receives the photograph that the observation device issues
The illumination light that the switching device reflects can be reflected into the surface of the sample by Mingguang City, first optical filter, be passed through
The illumination light of the surface reflection of sample is reflected into the observation device through first optical filter, by the switching device
In.
It further, further include microcobjective camera lens, the microcobjective camera lens is located at the sample and first filter
Between mating plate.
Further, the optical axis of second optical filter, switching device, the first optical filter and microcobjective camera lens is same
On straight line.
Further, first optical filter is two-color laser spectroscope.
Further, second optical filter is Raman optical filter.
Further, the export agency includes the first optical fiber and the first fiber coupler, and the introducing mechanism includes the
Two optical fiber and the second fiber coupler；
First optical fiber and first fiber coupler be sequentially arranged at the laser and first optical filter it
Between, second optical fiber and second fiber coupler are located between second optical filter and the spectrograph, described to swash
The laser signal that light device is launched enters in first optical fiber, and first fiber coupler is emitted to described first and filters
On piece, on the laser reflection to the sample for launched the laser by first optical filter, the second optical fiber coupling
Clutch and second optical fiber receive the reflection signal that the sample surfaces are inspired and filter, and by the sample surfaces quilt
It inspires and the reflection signal filtered is imported into the spectrograph.
Further, the switching device is to intervene/withdraw from changeable reflecting mirror, half-reflecting half mirror or polarization spectro
Mirror.
A kind of microscopic Raman detecting devices provided by the invention, by export agency, introducing mechanism, switching device, the first filter
Mating plate, the second optical filter, the laser and spectrograph form signal optical path, and what laser was launched in the signal optical path swashs
Optical signal acts on the sample surfaces, and the reflection signal that the sample surfaces are inspired, which enters, carries out Raman in spectrograph
Analysis, forms observation optical path by switching device, the first optical filter and observation device.Using above-mentioned scheme, observation optical path is main
For realizing the function of sample surfaces white-light illuminating and microexamination, it is equivalent to a complete optical microscope system.Compared to
Traditional optical microscopy, signal optical path are mainly used for realizing excitation and the collecting function of Raman signal, incident laser and most
The Raman scattering signal being collected into eventually is all to be carried out importing by means of export agency and introducing mechanism and derived, therefore its space
Position is very flexible, unrestricted；Often do not have micro- real-time observation to solve Raman probe existing in the prior art
Ability, and usually poor sensitivity, the spectral resolution technical problem low with spatial resolution.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is the structural schematic diagram of microscopic Raman detecting devices provided in an embodiment of the present invention.
In figure: 100- switching device；The first optical filter of 200-；300- microcobjective camera lens；The second optical filter of 400-；
500- introducing mechanism；600- laser；700- spectrograph；800- observation device；900- sample.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.The present invention being usually described and illustrated herein in the accompanying drawings is implemented
The component of example can be arranged and be designed with a variety of different configurations.
Therefore, the detailed description of the embodiment of the present invention provided in the accompanying drawings is not intended to limit below claimed
The scope of the present invention, but be merely representative of selected embodiment of the invention.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
It should also be noted that similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined in a attached drawing, does not then need that it is further defined and explained in subsequent attached drawing.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, or be somebody's turn to do
Invention product using when the orientation or positional relationship usually put, be merely for convenience of description of the present invention and simplification of the description, without
It is that the device of indication or suggestion meaning or element must have a particular orientation, be constructed and operated in a specific orientation, therefore not
It can be interpreted as limitation of the present invention.In addition, term " first ", " second ", " third " etc. are only used for distinguishing description, and cannot manage
Solution is indication or suggestion relative importance.
In addition, the terms such as term "horizontal", "vertical", " pendency " are not offered as requiring component abswolute level or pendency, and
It is that can be slightly tilted.It is not to indicate the structure if "horizontal" only refers to that its direction is more horizontal with respect to for "vertical"
It has to fully horizontally, but can be slightly tilted.
In the description of the present invention, it is also necessary to which explanation is unless specifically defined or limited otherwise, term " setting ",
" installation ", " connected ", " connection " shall be understood in a broad sense, for example, it may be fixedly connected, may be a detachable connection or one
Connect to body；It can be mechanical connection, be also possible to be electrically connected；It can be directly connected, it can also be indirect by intermediary
It is connected, can be the connection inside two elements.For the ordinary skill in the art, on being understood with concrete condition
State the concrete meaning of term in the present invention.
With reference to the accompanying drawing, it elaborates to some embodiments of the present invention.In the absence of conflict, following
Feature in embodiment and embodiment can be combined with each other.
A kind of be used for microscopic Raman detecting devices as shown in Figure 1, provided by the invention, comprising: export agency and successively every
The first optical filter 200, switching device 100, the second optical filter 400 and the introducing mechanism 500 being arranged；
First optical filter 200 is equipped with sample to be tested 900, first filter far from the side of the switching device 100
The side of mating plate 200 is equipped with laser 600, the export agency be located at the laser 600 and first optical filter 200 it
Between, the side of the switching device 100 is equipped with observation device 800, described in the laser signal process that the laser 600 is launched
Export agency is irradiated on first optical filter 200, and what first optical filter 200 can launch laser 600 swashs
Optical signal is reflected into 900 upper surface of sample, and the reflection signal that 900 surface of sample is inspired is by first filter
It is entered in the introducing mechanism 500 after mating plate 200, switching device 100 and the second optical filter 400, and by the introducing mechanism
500 imported into the spectrograph 700 and carry out Raman analysis；
The observation device 800 is located at 100 top of switching device, and the switching device 100 receives the observation dress
The illumination light of 800 sendings is set, the illumination light that the switching device 100 reflects can be reflected by first optical filter 200
The surface of the sample 900, by sample 900 surface reflection the illumination light through first optical filter 200, by described
Switching device 100 is reflected into the observation device 800.
It further, further include microcobjective camera lens 300, the microcobjective camera lens 300 is located at the sample 900 and institute
It states between the first optical filter 200.
Further, second optical filter 400, switching device 100, the first optical filter 200 and microcobjective camera lens 300
Optical axis on the same line.
Further, the first optical filter 200 is two-color laser spectroscope.Two-color laser spectroscope is a kind of beam splitter,
Wavelength can be made to reflect lower than the light of special value, and the light higher than the numerical value is allowed to penetrate.
Further, second optical filter 400 is Raman optical filter.Used herein is Edge optical filter, this is one
Kind long wave leads to (high pass) optical filter, it can be absorbed light of the wavelength lower than some special value and wavelength is allowed to be greater than the numerical value
Light passes through.For filtering out through the Rayleigh scattering and anti-Stokes scattering signal under being remained after two-color laser spectroscope, obtain
The Raman signal of " pure ".
Wherein, observation device 800 includes lighting source and image acquisition device.
Wherein, the first optical filter 200 and switching device 100 are symmetrical arranged, and the first optical filter 200 is to close to microcobjective
The inclination of 300 one end of camera lens.
In the present embodiment, filtered by export agency, introducing mechanism 500, switching device 100, the first optical filter 200, second
Piece 400, the laser 600 and spectrograph 700 form signal optical path, and excitation signal is emitted by laser 600, by exporting machine
Structure outgoing after the reflection of the first optical filter 200, and focuses on 900 surface of sample by microcobjective camera lens 300；900 table of sample
The scattering envelope that face is inspired includes reflected light signal, Rayleigh scattering signal (identical as laser wavelength of incidence), Stokes and draws
Graceful signal (wavelength is less than incident laser) and anti-Stokes Raman signal (wavelength is greater than incident laser), by microcobjective mirror
First 300 collect, and eliminate most of reflected light, Rayleigh scattering and anti-Stokes by the transmission of the first optical filter 200 and draw
Graceful signal and after retaining most Stokes Raman signals, filters out remaining reflected light, Rayleigh using the second filter
Scattering and anti-Stokes scattering signal, only Stokes Raman signal are able to by and are finally imported by introducing mechanism 500
Raman signal analysis is carried out into spectrograph 700, and sight is formed by switching device 100, the first optical filter 200 and observation device 800
Optical path is examined, the illumination light that the lighting source in observation device 800 issues, through the reflection of switching device 100, through the first optical filter
200 and 900 surface of sample is focused on by microcobjective camera lens 300；Illumination light is after 900 surface reflection of sample, by micro- object
Lens head 300 is collected, and is successively reflected by the first optical filter 200, switching device 100, is finally entered 800 formation figure of observation device
Picture realizes the observation to 900 surface of sample.Compared to traditional optical microscopy, signal optical path is mainly used for realizing Raman letter
Number excitation and collecting function, incident laser and the Raman scattering signal being finally collected into all be by means of export agency and to lead
Enter mechanism 500 import and derived, therefore its spatial position is very flexible, unrestricted；To solve to deposit in the prior art
Raman probe often do not have micro- real-time observing capacity, and usually poor sensitivity, spectral resolution and spatial discrimination
The low technical problem of rate.
On the basis of the above embodiments, further, the export agency includes the first optical fiber and the first fiber coupling
Device, the introducing mechanism 500 include the second optical fiber and the second fiber coupler；
First optical fiber and first fiber coupler are sequentially arranged at the laser 600 and first optical filter
Between 200, second optical fiber and second fiber coupler are located at second optical filter 400 and the spectrograph 700
Between, the laser signal that the laser 600 is launched enters in first optical fiber, the first fiber coupler transmitting
Onto first optical filter 200, the laser reflection for being gone out the Laser emission by first optical filter 200 is to the sample
On 900, second fiber coupler and second optical fiber receive the reflection that 900 surface of sample is inspired and filters
Signal, and 900 surface of sample is inspired and the reflection signal filtered is imported into the spectrograph 700.
In the present embodiment, due to setting for the first optical fiber, the first fiber coupler, the second optical fiber and the second fiber coupler
It sets, laser signal and filtered excitation signal can be made efficiently to pass in and out, so as to save space.
On the basis of the above embodiments, further, the switching device 100 is to intervene/withdraw from changeable reflection
Mirror, half-reflecting half mirror or polarization spectroscope.
In the present embodiment, when switching device 100 is using intervening/withdrawing from changeable reflecting mirror, then by intervening and withdrawing from
The switching of reflecting mirror realization observation optical path and signal optical path.If, can be automatic using half-reflecting half mirror or polarization spectroscope
It is divided and realizes automatically the switching of the two.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of microscopic Raman detecting devices characterized by comprising export agency and successively spaced first optical filtering
Piece, switching device, the second optical filter and introducing mechanism；
First optical filter is equipped with sample to be tested far from the side of the switching device, and the side of first optical filter is equipped with
Laser, the export agency are located between the laser and first optical filter, and the side of the switching device is equipped with
Observation device, the laser signal that the laser is launched are irradiated on first optical filter by the export agency, institute
The laser signal that laser can be launched by stating the first optical filter is reflected into the sample upper surface, and the sample surfaces are swashed
The reflection signal of sending enters in the introducing mechanism after first optical filter, switching device and the second optical filter,
And it is imported into spectrograph by the introducing mechanism and carries out Raman analysis；
The observation device is located above the switching device, and the switching device receives the illumination that the observation device issues
Light, the illumination light that the switching device reflects can be reflected into the surface of the sample by first optical filter, by sample
The illumination light of the surface reflection of product is reflected into the observation device through first optical filter by the switching device.
2. microscopic Raman detecting devices according to claim 1, which is characterized in that it further include microcobjective camera lens, it is described
Microcobjective camera lens is located between the sample and first optical filter.
3. microscopic Raman detecting devices according to claim 2, which is characterized in that second optical filter, switching device,
The optical axis of first optical filter and microcobjective camera lens is on the same line.
4. microscopic Raman detecting devices according to claim 1, which is characterized in that first optical filter is two-color laser
Spectroscope.
5. microscopic Raman detecting devices according to claim 1, which is characterized in that second optical filter is Raman optical filtering
Piece.
6. microscopic Raman detecting devices according to claim 1, which is characterized in that the export agency includes the first optical fiber
With the first fiber coupler, the introducing mechanism includes the second optical fiber and the second fiber coupler；
First optical fiber and first fiber coupler are sequentially arranged between the laser and first optical filter, institute
It states the second optical fiber and second fiber coupler is located between second optical filter and the spectrograph, the laser hair
The laser signal of injection enters in first optical fiber, and first fiber coupler is emitted on first optical filter,
On the laser reflection to the sample for launched the laser by first optical filter, second fiber coupler and
Second optical fiber receives the reflection signal that the sample surfaces are inspired and filter, and the sample surfaces are inspired
And the reflection signal filtered is imported into the spectrograph.
7. microscopic Raman detecting devices according to claim 1, which is characterized in that the switching device is to intervene/withdraw from
Changeable reflecting mirror, half-reflecting half mirror or polarization spectroscope.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910639345.4A CN110260974A (en) | 2019-07-15 | 2019-07-15 | Microscopic Raman detecting devices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910639345.4A CN110260974A (en) | 2019-07-15 | 2019-07-15 | Microscopic Raman detecting devices |
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| CN110260974A true CN110260974A (en) | 2019-09-20 |
Family
ID=67926365
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| CN201910639345.4A Pending CN110260974A (en) | 2019-07-15 | 2019-07-15 | Microscopic Raman detecting devices |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116392729A (en) * | 2023-05-29 | 2023-07-07 | 广州市五合医疗器械有限公司 | Laser therapeutic instrument |
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| US20050248759A1 (en) * | 2004-04-30 | 2005-11-10 | Peidong Wang | Method and apparatus for conducting Raman spectroscopy |
| CN102507002A (en) * | 2011-11-09 | 2012-06-20 | 厦门大学 | Optical fiber microprobe of tip-enhanced Raman spectrometer |
| CN103033497A (en) * | 2012-12-25 | 2013-04-10 | 吉林大学 | Microfluidic chip analyzer applying raman spectrum for detection |
| CN103743720A (en) * | 2014-01-20 | 2014-04-23 | 厦门大学 | Confocal microscopic Raman spectrometer with angle resolution capacity |
| CN105758838A (en) * | 2016-04-11 | 2016-07-13 | 北京大学 | Method and device for detecting and selecting laser-induce enhanced Raman spectrum in liquid |
| CN108717057A (en) * | 2018-05-31 | 2018-10-30 | 中央民族大学 | A kind of portable surface enhancing Raman spectrometer and its measurement method |
| CN209910826U (en) * | 2019-07-15 | 2020-01-07 | 天津大学 | micro-Raman detection device |
-
2019
- 2019-07-15 CN CN201910639345.4A patent/CN110260974A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050248759A1 (en) * | 2004-04-30 | 2005-11-10 | Peidong Wang | Method and apparatus for conducting Raman spectroscopy |
| CN102507002A (en) * | 2011-11-09 | 2012-06-20 | 厦门大学 | Optical fiber microprobe of tip-enhanced Raman spectrometer |
| CN103033497A (en) * | 2012-12-25 | 2013-04-10 | 吉林大学 | Microfluidic chip analyzer applying raman spectrum for detection |
| CN103743720A (en) * | 2014-01-20 | 2014-04-23 | 厦门大学 | Confocal microscopic Raman spectrometer with angle resolution capacity |
| CN105758838A (en) * | 2016-04-11 | 2016-07-13 | 北京大学 | Method and device for detecting and selecting laser-induce enhanced Raman spectrum in liquid |
| CN108717057A (en) * | 2018-05-31 | 2018-10-30 | 中央民族大学 | A kind of portable surface enhancing Raman spectrometer and its measurement method |
| CN209910826U (en) * | 2019-07-15 | 2020-01-07 | 天津大学 | micro-Raman detection device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN116392729A (en) * | 2023-05-29 | 2023-07-07 | 广州市五合医疗器械有限公司 | Laser therapeutic instrument |
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