CN110227113A - A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening and preparation method thereof for treating erection premature ejaculation - Google Patents

A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening and preparation method thereof for treating erection premature ejaculation Download PDF

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CN110227113A
CN110227113A CN201910615751.7A CN201910615751A CN110227113A CN 110227113 A CN110227113 A CN 110227113A CN 201910615751 A CN201910615751 A CN 201910615751A CN 110227113 A CN110227113 A CN 110227113A
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kidney
strengthening
chinese medicine
preparation
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莫小干
任国蓝
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Jiangxi Zhangshu Medical Biological Technology Co Ltd
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Jiangxi Zhangshu Medical Biological Technology Co Ltd
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Abstract

The invention discloses a kind of Chinese medicine compositions of kidney-reinforcing Yang-strengthening and preparation method thereof for treating erection premature ejaculation, it is related to technical field of traditional Chinese medicines, raw material includes: 3-7 parts of arillus longan, 10-17 parts of Rhizoma Atractylodis Macrocephalae, 10-17 parts of radix glycyrrhizae preparata, stock strand 15-25 parts of indigo plant, 3-7 parts of peach kernel, 8-15 parts of cynomorium songaricum, 8-15 parts of Semen Cuscutae, 8-15 parts of Herba Cistanches, 5-12 parts of ramulus cinnamomi, 5-12 parts of dried orange peel, 8-15 parts of thizoma curculiginis, 15-25 parts of Rehmannia glutinosa, 15-25 parts of Gorgon fruit, 10-17 parts of cortex albiziae, 10-17 parts of tuber fleeceflower stem by weight.The present invention selects a variety of natural pure traditional Chinese medicine raw materials, reasonable compatibility, it is synergistic, there is the effect of invigrating kidney, kidney-reinforcing Yang-strengthening, blood-enrich, soothing the liver tranquilizing the mind, controlling nocturnal emission with astringent drugs antidiarrheal, strengthen immunity, to improve body energy, the sex dysfunctions such as deficiency of the kidney, impotence, premature ejaculation, spermatorrhea are effectively prevented and treated, clinical effectiveness is good.

Description

A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening and preparation method thereof for treating erection premature ejaculation
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of Chinese medicine compositions for the kidney-reinforcing Yang-strengthening for treating erection premature ejaculation And preparation method thereof.
Background technique
Motherland's medicine thinks " the kidney being the origin of congenital constitution, and taste are the foundation of acquired constitution ", and the vital movement of human body depends on kidney yang Warm and essence of water and grain biochemistry is active.Kidney and partes corporis humani point suffer from close connection, the vital essence prosperity and decline direct relation of kidney To the health and aging of reproduction, growth, development and human body.Modern medicine believes that, kidney deficiency and endocrine system disorder, are immunized function Can low and cerebral cortex function etc. have close relationship, in sex dysfunction, have chronic diseases marked by deficiency of vital energy shower up to 85% or more.However After man 40 years old, Yangming Channel arteries and veins qi and blood degradation is weak, and kidney qi decline, is the natural law.
The drug of kidney-reinforcing Yang-strengthening and health care product are more currently on the market, wherein be also no lack of have in some tonifying kidney and strengthening yangs at Medicine, but mostly effect is not fairly obvious, the still most depending on western medicine of patient.The effect of Western medicine establishing-Yang performance is fast and strong, but only Superficial phenomenon is that stimulation human body goes to consume remaining kidney qi in fact, and kidney qi of overdrawing in advance is tight commonly using will lead to body instead Weight dystrophy, deficiency of kidney-QI are palliative.
Summary of the invention
Technical problems based on background technology, the invention proposes in a kind of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation Drug composition and preparation method thereof can be effectively prevented and treated the sex dysfunctions such as deficiency of the kidney, impotence, premature ejaculation, spermatorrhea, clinic effect Fruit is good.
A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation proposed by the present invention, raw material wrap by weight Include: 3-7 parts of arillus longan, 10-17 parts of Rhizoma Atractylodis Macrocephalae, 10-17 parts of radix glycyrrhizae preparata, stock twist 15-25 parts of indigo plant, 3-7 parts of peach kernel, 8-15 parts of cynomorium songaricum, 8-15 parts of Semen Cuscutae, 8-15 parts of Herba Cistanches, 5-12 parts of ramulus cinnamomi, 5-12 parts of dried orange peel, 8-15 parts of thizoma curculiginis, 15-25 parts of Rehmannia glutinosa, Gorgon fruit 15-25 parts, 10-17 parts of cortex albiziae, 10-17 parts of tuber fleeceflower stem.
Preferably, raw material includes: 5 parts of arillus longan, 14 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 14 part, burst strand blue 20 parts, peach by weight 5 parts of benevolence, 12 parts of cynomorium songaricum, 12 parts of Semen Cuscutae, 12 parts of Herba Cistanches, 9 parts of ramulus cinnamomi, 10 parts of dried orange peel, 12 parts of thizoma curculiginis, 20 parts of Rehmannia glutinosa, Gorgon euryale Real 22 parts, 13 parts of cortex albiziae, 13 parts of tuber fleeceflower stem.
The invention also provides the preparation methods of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening of above-mentioned treatment erection premature ejaculation, including with Lower step:
S1, arillus longan, peach kernel are pulverized, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2It is super to face In boundary's extractor, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract obtains extract liquor；
S3, to CO275-85% ethanol solution, ultrasonic extraction are added in the dregs of a decoction after supercritical extract, filtering obtains alcohol extracting Liquid；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crushes, adds water to cook extraction, mistake Filter, obtains Aqueous extracts, is concentrated under reduced pressure, dry, obtains powder c；
S6, powder a, powder b and powder c are mixed, obtain mixed powder, pharmaceutically acceptable auxiliary material is added thereto, Preparation is made according to a conventional method.
Preferably, it in S1, pulverizes to 180-200 mesh.
Preferably, in S2, the percent by volume of the total extractant of entrainer Zhan is 4-6%, extracting pressure 15-25MPa, extraction 40-50 DEG C of temperature is taken, CO2Flow 1-3ml/g crude drug min, extraction time 1-2h.
Preferably, in S3, the 75-85% ethanol solution of 4-7 times of medicinal material initial mass of addition, ultrasonic extraction 30-50min, Ultrasonic power is 600-800W.
Preferably, in S5, extraction 1-2 times is added water to cook, extracts 1-2h every time, filtered after extracting every time.
Preferably, in S6, the preparation is oral preparation.
Preferably, the preparation is granule.
It is as follows the effect of each material medicine in the present invention:
Arillus longan: warm-natured, sweet in flavor, thoughts of returning home warp, the spleen channel have the effect of tonifying heart and spleen, nourishing blood and tranquilization；With controlling heart and spleen deficiency Palpitaition, amnesia, diarrhea, oedema etc., insufficiency of vital energy and blood and induced insomnia, metrorrhagia and metrostaxis, menstrual vertigo, lung yin virtual loss, lung lose profit drop and cause Dry cough, phlegm stick white, hoarseness, dry mouth and throat etc. less；It is clinically used for nourishing, interior Ménière, disease of digestive system and coronary heart disease Deng.
Rhizoma Atractylodis Macrocephalae: warm-natured, sweet in flavor, bitter, converge to the spleen channel, stomach meridian have the effect of invigorating the spleen, QI invigorating, eliminate dampness and have diuretic effect, hidroschesis；With controlling Deficient QI of the spleen and stomach, do not feel like eating, burnout lack gas, empty swollen, diarrhea, phlegm retention, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination, dizziness, spontaneous perspiration, Nausea uneasiness etc..
Radix glycyrrhizae preparata: warm-natured, sweet in flavor, thoughts of returning home warp, lung channel, stomach meridian, the spleen channel have the effect of tonifying spleen stomach function regulating, Yiqi and vein recovery；With In treating weakness of the spleen and the stomach, fatigue and weakness, palpitaition is dynamic, knotted pulse.
Stock twists blue: cold in nature, bitter, distributed in lung channel, the spleen channel, kidney channel have the effect of clearing heat and detoxicating, cough-relieving apophlegmatic；It is slow with controlling Property tracheitis, bronchial asthma, hyperlipidemia, artery sclerosis, hepatitis, various tumours, canker and insomnia, headache, white hair etc.； Immune function can be enhanced, the influence of body nospecific immunity can be increased, male mouse testis can be remarkably reinforced in mouse gavaging water decoction The weight of ball, seminal vesicle, spleen, prostate and female mice uterus has the effects that male and female hormone sample, improves macrophage function.
Peach kernel: mild-natured, bitter, sweet, thoughts of returning home warp, Liver Channel, large intestine channel have the effect of activating blood circulation and dissipating phlegm, relax bowel and defecation；With controlling Menostasis, dysmenorrhea, lump in the abdomen, traumatic injury, intestinal dryness and constipation.
Cynomorium songaricum: warm-natured, sweet in flavor, converge to the spleen channel, kidney channel, large intestine channel have the effect of kidney-replenishing, benefiting essence-blood, relax bowel and defecation；With Control waist knee impotence, impotence involuntary emission, dry constipation of intestines.Impotence caused by the insufficiency of the kidney yang can be treated with Semen Cuscutae, Herba Cistanches compatible use Premature ejaculation, female sterility.
Semen Cuscutae: mild-natured, acrid flavour, sweet, return liver warp, kidney channel, the spleen channel have the effect of tonifying kidney and benefiting sperm, nourishing the liver tomorrow；For Lumbago due to the kidney deficiency, impotence, premature ejaculation, turbid urine, leukorrhagia, frequent urination；Threatened abortion, threatened abortion；Kidney deficiency and liver, blurring of vision, depending on Power decline.
Herba Cistanches: it is warm-natured, it is sweet in flavor, salty, return kidney channel, large intestine channel, kidney-replenishing, the benefiting essence-blood, effect of relaxing bowel having；With In waist knee impotence, impotence, female sterility, dry constipation of intestines.
Ramulus cinnamomi: it is acrid flavour, sweet, it is warm-natured, return bladder meridian, the heart channel of Hang-Shaoyin, lung channel, have relieving muscles diaphoresis, warming meridians and promoting circulation of qi, helps yang transforming qi, The effect of flat gas that spins；With controlling anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, arthralgia, phlegm retention, oedema, palpitaition, renal mass.
Dried orange peel: acrid flavour, bitter, warm-natured, converge to the spleen channel, lung channel have the effect of qi-regulating appetizing, eliminating dampness and eliminating phlegm；With controlling chest gastral cavity Turgor, deficiency of food vomiting, coughing with a lot of sputum.
Thizoma curculiginis: property heat, acrid flavour return kidney channel, Liver Channel, the spleen channel, have the effect of kidney-replenishing, strengthening the bones and muscles, dispellieg cold and dampness；With controlling sun Impotence cold sperm, aconuresis, metrorrhagia and metrostaxis, trusted subordinate's crymodynia, cold arthralgia of loins and legs, ulcer, scrofula etc..
Rehmannia glutinosa: slightly warm in nature, sweet in flavor, return liver warp, kidney channel have the effect of enriching yin of enriching blood, beneficial to spirit and marrow；It withers for the deficiency of blood Huang, palpitation and severe palpitation, irregular menstruation, metrostaxis, the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat spermatorrhea, Heat Diabetes are dizzy It is dizzy, tinnitus, poliosis.
Gorgon fruit: mild-natured, sweet in flavor, puckery, converge to the spleen channel, kidney channel have the effect of supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, eliminating dampness and arresting leucorrhea；With Control emission and spermatorrhea, enuresis frequent micturition, spleen deficiency chronic diarrhea, gonorrhoea, leukorrhagia.
Cortex albiziae: mild-natured, sweet in flavor, thoughts of returning home warp, Liver Channel, lung channel have the effect of resolving stagnation for tranquilization, activating blood circulation and reducing swelling；With controlling the heart Refreshing uneasy, melancholy insomnia, pulmonary abscess sore swells, traumatic injury.It is modern with controlling confused and worried, melancholy insomnia.
Tuber fleeceflower stem: mild-natured, sweet in flavor, thoughts of returning home warp, Liver Channel have the effect of nourishing blood and tranquilization, dispelling wind and removing obstruction in the meridians；With controlling, insomnia is more Dream, deficiency of blood bodily pain, rheumatic arthralgia；Pruitus is controlled outside.
The utility model has the advantages that the present invention provides a kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation and its preparation sides Method selects a variety of natural pure traditional Chinese medicine raw materials, and reasonable compatibility is synergistic, there is invigrating kidney, kidney-reinforcing Yang-strengthening, blood-enrich, soothing the liver Calm the nerves, controlling nocturnal emission with astringent drugs antidiarrheal, strengthen immunity the effect of, to improve body energy, be effectively prevented and treated deficiency of the kidney, impotence, premature ejaculation, Sex dysfunctions, the clinical effectiveness such as spermatorrhea are good.
Specific embodiment
In the following, technical solution of the present invention is described in detail by specific embodiment.
Embodiment 1
A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation proposed by the present invention, raw material wrap by weight Include: 3 parts of arillus longan, 17 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 10 part, strand twist blue 15 parts, 7 parts of peach kernel, 8 parts of cynomorium songaricum, 15 parts of Semen Cuscutae, Herba Cistanches 15 parts, 5 parts of ramulus cinnamomi, 12 parts of dried orange peel, 8 parts of thizoma curculiginis, 15 parts of Rehmannia glutinosa, 25 parts of Gorgon fruit, 17 parts of cortex albiziae, 10 parts of tuber fleeceflower stem.
The invention also provides the preparation methods of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening of above-mentioned treatment erection premature ejaculation, including with Lower step:
S1, arillus longan, peach kernel are pulverized to 180 mesh, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2It is super to face In boundary's extractor, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract, the percent by volume of the total extractant of entrainer Zhan It is 4%, extracting pressure 15MPa, 40 DEG C of extraction temperature, CO2Flow 1ml/g crude drug min, extraction time 1h obtain extract liquor；
S3, to CO24 times of medicinal material initial mass of 75% ethanol solution is added in the dregs of a decoction after supercritical extract, ultrasound mentions 30min, ultrasonic power 600W are taken, filters, obtains alcohol extract；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crushes, adds water to cook and extract 2h, mistake Filter, obtains Aqueous extracts, is concentrated under reduced pressure, dry, obtains powder c；
S6, powder a, powder b and powder c are mixed, obtains mixed powder, crushed, starch and dextrin, system are added thereto Grain, tabletting is to get tablet.
Embodiment 2
A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation proposed by the present invention, raw material wrap by weight Include: 7 parts of arillus longan, 10 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 17 part, strand twist blue 25 parts, 3 parts of peach kernel, 15 parts of cynomorium songaricum, 8 parts of Semen Cuscutae, Herba Cistanches 8 parts, 12 parts of ramulus cinnamomi, 5 parts of dried orange peel, 15 parts of thizoma curculiginis, 25 parts of Rehmannia glutinosa, 15 parts of Gorgon fruit, 10 parts of cortex albiziae, 17 parts of tuber fleeceflower stem.
The invention also provides the preparation methods of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening of above-mentioned treatment erection premature ejaculation, including with Lower step:
S1, arillus longan, peach kernel are pulverized to 200 mesh, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2It is super to face In boundary's extractor, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract, the percent by volume of the total extractant of entrainer Zhan It is 6%, extracting pressure 25MPa, 50 DEG C of extraction temperature, CO2Flow 3ml/g crude drug min, extraction time 2h obtain extract liquor；
S3, to CO27 times of medicinal material initial mass of 85% ethanol solution is added in the dregs of a decoction after supercritical extract, ultrasound mentions 50min, ultrasonic power 800W are taken, filters, obtains alcohol extract；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crush, adds water to cook extraction 2 times, 2h is extracted for the first time, second of extraction 1.5h is filtered, merging filtrate after extracting every time, is concentrated under reduced pressure, and it is dry, obtain powder c；
S6, powder a, powder b and powder c are mixed, obtains mixed powder, crushed, a little talcum powder and tristearin is added in granulation Sour magnesium mixes, and is packed into capsule to get capsule.
Embodiment 3
A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation proposed by the present invention, raw material wrap by weight Include: 6 parts of arillus longan, 15 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 12 part, strand twist blue 22 parts, 4 parts of peach kernel, 10 parts of cynomorium songaricum, 14 parts of Semen Cuscutae, meat desert 10 parts of Rong, 7 parts of ramulus cinnamomi, 8 parts of dried orange peel, 10 parts of thizoma curculiginis, 22 parts of Rehmannia glutinosa, 18 parts of Gorgon fruit, 15 parts of cortex albiziae, 15 parts of tuber fleeceflower stem.
The invention also provides the preparation methods of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening of above-mentioned treatment erection premature ejaculation, including with Lower step:
S1, arillus longan, peach kernel are pulverized to 190 mesh, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2It is super to face In boundary's extractor, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract, the percent by volume of the total extractant of entrainer Zhan It is 4.5%, extracting pressure 18MPa, 45 DEG C of extraction temperature, CO2Flow 1.7ml/g crude drug min, extraction time 1.5h must extract Take liquid；
S3, to CO25 times of medicinal material initial mass of 75% ethanol solution is added in the dregs of a decoction after supercritical extract, ultrasound mentions 40min, ultrasonic power 700W are taken, filters, obtains alcohol extract；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crush, adds water to cook extraction 2 times, 1.5h is extracted every time, is filtered after extracting every time, merging filtrate, is concentrated under reduced pressure, it is dry, obtain powder c；
S6, powder a, powder b and powder c are mixed, obtains mixed powder, cane sugar powder is added into mixed powder, dextrin, does Starch, wherein mixed powder, cane sugar powder, dextrin, dried starch mass ratio be 40:10:10:40, it is dry using wet granulation, Whole grain is packed to get granule.
Embodiment 4
A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening for treating erection premature ejaculation proposed by the present invention, raw material wrap by weight Include: 5 parts of arillus longan, 14 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 14 part, strand twist blue 20 parts, 5 parts of peach kernel, 12 parts of cynomorium songaricum, 12 parts of Semen Cuscutae, meat desert 12 parts of Rong, 9 parts of ramulus cinnamomi, 10 parts of dried orange peel, 12 parts of thizoma curculiginis, 20 parts of Rehmannia glutinosa, 22 parts of Gorgon fruit, 13 parts of cortex albiziae, 13 parts of tuber fleeceflower stem.
The invention also provides the preparation methods of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening of above-mentioned treatment erection premature ejaculation, including with Lower step:
S1, arillus longan, peach kernel are pulverized to 200 mesh, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2It is super to face In boundary's extractor, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract, the percent by volume of the total extractant of entrainer Zhan It is 5%, extracting pressure 22MPa, 50 DEG C of extraction temperature, CO2Flow 2ml/g crude drug min, extraction time 1.5h obtain extract liquor；
S3, to CO26 times of medicinal material initial mass of 80% ethanol solution is added in the dregs of a decoction after supercritical extract, ultrasound mentions 45min, ultrasonic power 800W are taken, filters, obtains alcohol extract；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crush, adds water to cook extraction 2 times, 2h is extracted for the first time, second of extraction 1h is filtered, merging filtrate after extracting every time, is concentrated under reduced pressure, and it is dry, obtain powder c；
S6, powder a, powder b and powder c are mixed, obtains mixed powder, cane sugar powder is added into mixed powder, dextrin, does Starch, wherein mixed powder, cane sugar powder, dextrin, dried starch mass ratio be 40:10:10:40, it is dry using wet granulation, Cross 10 mesh sieves, pack, 25g per bag to get.
It is examined through Composition analyzed and clinical case, the Chinese medicine composition effect in embodiment 4 is best.
Clinical data
1, case selection
1.1 diagnostic criteria
Penis anorthosis or erection be not hard when sexual intercourse, not can enter vagina；Though or can enter, cannot be lasting so that Normal sexual intercourse cannot be completed by having 75% or more chance.
1.2 Standards of Chinese Medical Syndrome Differentiation
The insufficiency of the kidney yang, syndrome of stagnation of liver qi and blood stasis: have following primary symptom binomial, minor symptom binomial and tongue vein person.
Primary symptom: impotence or lift without hard or hard and soon；Soreness and weakness of waist and knees；Aversion to cold and cold limbs.
Minor symptom: spiritual gloomy or dispirited, pale complexion, enuresis nocturna frequency, sexual hypoesthesia, seminal fluid being thin and cold, Breast bilges frowsty, pale tongue or Secretly there is an ecchymosis, whitish tongue is deep thready pulse or string, puckery.
1.3 are included in standard
(1) it closes and states diagnostic criteria and Standards of Chinese Medical Syndrome Differentiation；(2) course of disease was at 3 months or more；(3) age was at 20 years old -60 Year；(4) there are regular sex partners；(5) erectile dysfunction International Index asks that certificate scores (IIEF-5)≤21 point.
1.4 exclusion criteria
(1) age at 20 years old hereinafter, or 60 years old or more；(2) separation or spouse have the unsuitable sexual life person of serious disease；(3) Indulge in excessive drinking, take drugs or have other drugs dependent；(4) complication with diabetes patient；(5) it has been associated with serious angiocarpy, liver, exhaled The patients such as suction and hemopoietic system disease；(6) mental patient；(7) prostate obviously increase survivor or forefront specific antigen (PSA) > 4ug/ml person；(8) other related drugs person was taken in the recent period.
2, general information
100 sex dysfunction patients are selected by standard, the age 22-60 years old, the course of disease -8 years 3 months, are randomly divided into two groups, Treatment group and control group, every group each 50；Wherein, treatment group's average age 36 ± 1.8 years old, control group 35 ± 2.5 years old, two groups of trouble Difference (P > 0.05) that person's age, the course of disease, erection function, state of an illness weight, IIEF-5 scoring etc., there are no significant, having can Compare property.
3, treatment method
Treatment group: taking the Chinese medicine composition prepared in the embodiment of the present invention 4, take after mixing it with water, once a bag, 2 times a day；
Control group: taking Liuwei Dihuang Wan, takes orally, and 8 every time, 3 times a day；
Two groups are treated 8 weeks, before treatment, are observed IIEF-5 integral respectively and are changed within treatment 4 weeks, treatment 8 weeks, including penis is vigorous It plays confidence, be successively inserted into number, erection hardness maintains 5 problems of erectile ability and coitus satisfaction degree.
4, clinical observation on the therapeutic effect index
Cure: sexual intercourse chance integrates >=21 points up to 75% or more success or erection function after treatment；
Effective: sexual intercourse chance increases 7-14 points up to 50% or more success or erection function integral earlier above after treatment；
Effective: sexual intercourse chance increases≤7 points up to 25% or more success or erection function integral earlier above after treatment；
Invalid: sexual intercourse chance success rate is unchanged after treatment or erection function integral is without increase.
5, treatment results
Two groups treat 8 weeks after count curative effect, as a result see the table below.
It cures It is effective Effectively In vain Effective percentage/%
Treatment group 21 18 9 2 96
Control group 13 11 18 8 84
Note: two groups of curative effects relatively have significant difference (P < 0.05).
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (9)

1. a kind of Chinese medicine composition for the kidney-reinforcing Yang-strengthening for treating erection premature ejaculation, which is characterized in that its raw material includes: dragon by weight 3-7 parts of eye meat, 10-17 parts of Rhizoma Atractylodis Macrocephalae, 10-17 parts of radix glycyrrhizae preparata, stock twist 15-25 parts of indigo plant, 3-7 parts of peach kernel, 8-15 parts of cynomorium songaricum, Semen Cuscutae 8-15 parts, 8-15 parts of Herba Cistanches, 5-12 parts of ramulus cinnamomi, 5-12 parts of dried orange peel, 8-15 parts of thizoma curculiginis, 15-25 parts of Rehmannia glutinosa, Gorgon fruit 15-25 Part, 10-17 parts of cortex albiziae, 10-17 parts of tuber fleeceflower stem.
2. the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 1, which is characterized in that its raw material It by weight include: 5 parts of arillus longan, 14 parts of Rhizoma Atractylodis Macrocephalae, radix glycyrrhizae preparata 14 part, burst strand blue 20 parts, 5 parts of peach kernel, 12 parts of cynomorium songaricum, Semen Cuscutae 12 parts, 12 parts of Herba Cistanches, 9 parts of ramulus cinnamomi, 10 parts of dried orange peel, 12 parts of thizoma curculiginis, 20 parts of Rehmannia glutinosa, 22 parts of Gorgon fruit, 13 parts of cortex albiziae, night friendship 13 parts of rattan.
3. a kind of preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening based on treatment erection premature ejaculation of any of claims 1 or 2, Characterized by comprising the following steps:
S1, arillus longan, peach kernel are pulverized, mixing obtains powder a, spare；
S2, Rhizoma Atractylodis Macrocephalae, ramulus cinnamomi, dried orange peel, Rehmannia glutinosa, Gorgon fruit, cortex albiziae, tuber fleeceflower stem are crushed, mixing is added to CO2Supercritical extract In device, using ethyl alcohol as entrainer, CO is carried out2Supercritical extract obtains extract liquor；
S3, to CO275-85% ethanol solution, ultrasonic extraction are added in the dregs of a decoction after supercritical extract, filtering obtains alcohol extract；
S4, extract liquor and alcohol extract are mixed, ethyl alcohol is recovered under reduced pressure, be concentrated under reduced pressure, it is dry, obtain powder b；
S5, radix glycyrrhizae preparata, stock are twisted to indigo plant, cynomorium songaricum, Semen Cuscutae, Herba Cistanches, thizoma curculiginis mixing, crushes, add water to cook extraction, filters, obtain Aqueous extracts are concentrated under reduced pressure, dry, obtain powder c；
S6, powder a, powder b and powder c are mixed, obtains mixed powder, pharmaceutically acceptable auxiliary material is added thereto, by normal Preparation is made in rule method.
4. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 3, feature It is, in S1, pulverizes to 180-200 mesh.
5. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 3, feature It is, in S2, the percent by volume of the total extractant of entrainer Zhan is 4-6%, extracting pressure 15-25MPa, extraction temperature 40- 50 DEG C, CO2Flow 1-3ml/g crude drug min, extraction time 1-2h.
6. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 3, feature It is, in S3, the 75-85% ethanol solution of 4-7 times of medicinal material initial mass, ultrasonic extraction 30-50min is added, ultrasonic power is 600-800W。
7. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 3, feature It is, in S5, adds water to cook extraction 1-2 times, extract 1-2h every time, filtered after extracting every time.
8. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 3, feature It is, in S6, the preparation is oral preparation.
9. the preparation method of the Chinese medicine composition of the kidney-reinforcing Yang-strengthening for the treatment of erection premature ejaculation according to claim 8, feature It is, the preparation is granule.
CN201910615751.7A 2019-07-09 2019-07-09 A kind of Chinese medicine composition of kidney-reinforcing Yang-strengthening and preparation method thereof for treating erection premature ejaculation Pending CN110227113A (en)

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Application publication date: 20190913