CN110221090B - Air suction and air discharge preventing system and method applying chemiluminescence analyzer - Google Patents
Air suction and air discharge preventing system and method applying chemiluminescence analyzer Download PDFInfo
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- CN110221090B CN110221090B CN201910542105.2A CN201910542105A CN110221090B CN 110221090 B CN110221090 B CN 110221090B CN 201910542105 A CN201910542105 A CN 201910542105A CN 110221090 B CN110221090 B CN 110221090B
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
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Abstract
The application relates to an anti-empty suction and empty discharge system and method for a chemiluminescence analyzer, wherein the system comprises a reaction mechanism, a sampling needle mechanism and a monitoring mechanism, the reaction mechanism comprises a reaction cup, the sampling needle mechanism comprises a sampling needle with a liquid level detection function, the monitoring mechanism comprises a processor, wherein: during sample suction, the sampling needle sucks liquid in the reaction cup, and the processor monitors a liquid level detection waveform signal of the sampling needle and judges whether the sampling needle is sucked empty; during sample discharging, the sampling needle discharges liquid into the reaction cup, and the processor monitors the liquid level detection waveform signal of the sampling needle and judges whether the sampling needle is empty or not. The invention has novel structure and ingenious design, judges whether the liquid is empty or not through the retention time of the liquid level detection waveform during liquid suction, and judges whether the liquid is empty or not through the liquid level detection waveform generated during liquid discharge, and provides a quick and efficient system and a method for preventing the empty suction and the empty discharge by using the chemiluminescence analyzer.
Description
Technical Field
The application belongs to the technical field of medical instruments, and particularly relates to an anti-empty suction and air discharge system and method applying a chemiluminescence analyzer.
Background
The most commonly used diagnostic method in the medical field, in vitro diagnosis, is to collect body fluids, excretions, secretions and the like of a human body and analyze chemical components or chemical reactions so as to judge the pathological changes of the human body. The in vitro diagnostic methods include chemiluminescence analysis, molecular diagnosis and the like, and all the diagnostic methods adopt automatic or semi-automatic instruments for sample adding and analysis and give diagnostic reports.
Among them, the chemiluminescence analysis method mainly uses a sample adding needle to suck and discharge samples and reagents. However, the amount of liquid or other problems may cause abnormality such as suction and discharge of the sample addition needle, which may cause abnormality in the diagnosis result.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the system and the method for preventing the air suction and the air discharge by applying the chemiluminescence analyzer are rapid and efficient, and are used for solving the problem that the detection and the coping capability of abnormal conditions such as the air suction and the air discharge are insufficient in the chemiluminescence analysis diagnosis method in the prior art.
The technical scheme adopted by the invention for solving the technical problems is as follows:
an air suction and air discharge prevention system for a chemiluminescence analyzer, comprising a reaction mechanism, a sampling needle mechanism and a monitoring mechanism, wherein the reaction mechanism comprises a reaction cup, the sampling needle mechanism comprises a sampling needle with a liquid level detection function, and the monitoring mechanism comprises a processor, wherein:
during sample suction, the sampling needle sucks liquid in the reaction cup, and the processor monitors a liquid level detection waveform signal of the sampling needle and judges whether the sampling needle is sucked empty;
during sample discharging, the sampling needle discharges liquid into the reaction cup, and the processor monitors the liquid level detection waveform signal of the sampling needle and judges whether the sampling needle is empty or not.
In one embodiment, the monitoring mechanism further comprises an alarm that alarms when the processor detects suction or evacuation.
An air suction and air discharge preventing method for a chemiluminescence analyzer comprises the following steps during sample suction:
step 10, setting a preset attenuation slope of a liquid level detection waveform and a preset amplitude of the liquid level detection waveform for a processor;
step 20, when the sampling needle detects the liquid level, the processor starts timing;
step 30, when the liquid level detection waveform attenuation slope is smaller than the preset attenuation slope and the liquid level detection waveform amplitude is smaller than the preset amplitude, stopping timing by the processor and recording timing time;
step 40, when the timing time is less than or equal to 1.1s, the processor judges that the sample suction of the sampling needle is normal, and when the timing time is more than 1.1s, the processor judges that the sampling needle is sucked in an empty mode;
the stock layout comprises the following steps:
step 100, setting a preset amplitude value of a liquid level detection waveform for the processor;
200, when the sampling needle performs sampling, the processor acquires a liquid level detection waveform;
and 300, when the liquid level detection waveform is larger than or equal to the preset amplitude, the processor judges that the sample discharge of the sampling needle is normal, and when the liquid level detection waveform is smaller than the preset amplitude, the processor judges that the sample discharge of the sampling needle is empty.
In one embodiment, in step 20:
and when the liquid level cannot be detected by the sampling needle, the amplitude of the liquid level detection waveform is smaller than the preset amplitude, and the sample suction is stopped at the moment.
In one embodiment, in step 30:
and when the liquid level detection waveform attenuation slope is greater than or equal to the preset attenuation slope or the liquid level detection waveform amplitude is greater than or equal to the preset amplitude, the processor continues timing and collects the liquid level detection waveform signals again.
In one embodiment, the method further comprises the step 50:
and after the processor judges that the sampling needle is empty and sucked, the processor sends an error signal.
In one embodiment, the method further comprises the step 400:
and after the processor judges that the sampling needle is empty, the processor sends out an error signal.
In one embodiment, the chemiluminescent analyzer further comprises an alarm that receives the error signal and issues an alarm.
The invention has the beneficial effects that: the invention has novel structure and ingenious design, judges whether the liquid is empty or not through the retention time of the liquid level detection waveform during liquid suction, judges whether the liquid is empty or not through the liquid level detection waveform generated during liquid discharge, and provides a system and a method for preventing the empty suction and the empty discharge by applying the chemiluminescence analyzer quickly and efficiently in order to solve the problem of insufficient detection and coping capability of abnormal conditions such as the empty suction and the empty discharge in the chemiluminescence analysis diagnosis method in the prior art.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a schematic structural diagram of an anti-air suction and air discharge system of a chemiluminescence analyzer in an embodiment of the application;
FIG. 2 is a partial schematic view of an anti-air-suction and air-discharge system of a chemiluminescence analyzer according to an embodiment of the application;
FIG. 3 is a flow chart of the sample extraction waveform determination according to the embodiment of the present application;
fig. 4 is a flowchart illustrating a determination of a stock layout waveform according to an embodiment of the present application.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific situations.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
An air suction and air discharge preventing system applying a chemiluminescence analyzer comprises a reaction mechanism 1, a sampling needle mechanism 2 and a monitoring mechanism. The reaction mechanism 1 is used for providing temporary storage and reaction sites for samples and reagents, and the reaction mechanism 1 comprises a reaction cup 3 for receiving the samples and the reagents. The probe mechanism 2 includes a probe 4 having a liquid level detection function, and in some embodiments includes a driving device such as a motor or the like that drives the probe 4 to move. The monitoring mechanism comprises a processor (CPU), and the monitoring mechanism is arranged in the applied chemiluminescence analyzer and can be externally arranged and controlled by a wireless transmitting and receiving device in different embodiments. Wherein: during sample suction, when the sampling needle 4 sucks liquid such as a sample, a reagent and the like in the reaction cup for action, the processor monitors a liquid level detection waveform signal of the sampling needle 4 and judges whether the sampling needle 4 is sucked empty or not; during the sample arrangement, when the sampling needle 4 discharges liquid into the reaction cup, the processor monitors the liquid level detection waveform signal of the sampling needle 4 and judges whether the sampling needle 4 is empty or not. The sampling needle 4 capable of detecting the liquid level detection waveform signal is not repeated in the conventional technology, and the liquid level state, especially the liquid level waveform signal is utilized to judge the empty discharge and the empty suction conditions, so that the existing mechanism is well utilized, the conception is ingenious, and the result is accurate.
To improve the responsiveness to the detection of aspiration or evacuation, in one embodiment, the monitoring mechanism further includes an alarm that alarms when the processor detects aspiration or evacuation. The alarm may be a flashing light or a buzzer or the like connected and controlled by the processor.
The embodiment of the invention also discloses an air suction and air discharge prevention method by using the chemiluminescence analyzer, and specifically comprises the following steps of:
step 10, setting a preset attenuation slope of a liquid level detection waveform and a preset amplitude of the liquid level detection waveform for a processor;
step 20, when the sampling needle 4 detects the liquid level, the processor starts timing;
step 30, when the liquid level detection waveform attenuation slope is smaller than the preset attenuation slope and the liquid level detection waveform amplitude is smaller than the preset amplitude, stopping timing by the processor and recording timing time;
step 40, when the timing time is less than or equal to 1.1s, the processor judges that the sample suction of the sampling needle 4 is normal, and when the timing time is more than 1.1s, the processor judges that the sampling needle 4 is sucked in an empty mode;
the stock layout comprises the following steps:
step 100, setting a preset amplitude value of a liquid level detection waveform for a processor;
step 200, when the sampling needle 4 performs sampling, the processor acquires a liquid level detection waveform;
and step 300, when the liquid level detection waveform is larger than or equal to the preset amplitude, the processor judges that the sample discharging of the sampling needle 4 is normal, and when the liquid level detection waveform is smaller than the preset amplitude, the processor judges that the sample discharging of the sampling needle 4 is empty.
In one embodiment, in step 20:
when the liquid level can not be detected by the sampling needle 4, the amplitude of the liquid level detection waveform is smaller than the preset amplitude, and the sample suction is stopped at the moment.
The invention principle is as follows: when the sample suction is normal, the time from the probe 4 to the liquid surface in the sample suction waveform to the end of the sample suction (namely the waveform returns to 0) is about 1 s; when the stock-out is normal, the waveform can trigger the liquid level detection threshold. During the air suction, the time from the probe 4 to the liquid surface in the sample suction waveform to the end of the sample suction (namely the waveform returns to 0) is about 1.6 s; the empty waveform is not able to trigger the level detection threshold. Therefore, whether the sample sucking needle 4 sucks the sample is judged by calculating the time from the sample sucking needle 4 touching the liquid level to the attenuation of the sample sucking waveform amplitude to be close to 0; and judging whether the sample sucking needle 4 is empty or not by triggering a liquid level detection threshold value through a waveform during sample discharging. In one embodiment, step 30:
and when the liquid level detection waveform attenuation slope is greater than or equal to the preset attenuation slope or the liquid level detection waveform amplitude is greater than or equal to the preset amplitude, the processor continues to time and collects the liquid level detection waveform signals again.
In one embodiment, the method further comprises the step 50:
and after the processor judges that the sampling needle 4 is sucked, the processor sends an error signal.
In one embodiment, the method further comprises the step 400:
after the processor judges that the sampling needle 4 is empty, the processor sends out an error signal.
To improve the ability to monitor the reaction when suction or evacuation is detected, in one embodiment, the chemiluminescent analyzer further includes an alarm that receives an error signal and issues an alarm.
The invention has the beneficial effects that: the invention has novel structure and ingenious design, judges whether the liquid is empty or not through the retention time of the liquid level detection waveform during liquid suction, judges whether the liquid is empty or not through the liquid level detection waveform generated during liquid discharge, and provides a system and a method for preventing the empty suction and the empty discharge by applying the chemiluminescence analyzer quickly and efficiently in order to solve the problem of insufficient detection and coping capability of abnormal conditions such as the empty suction and the empty discharge in the chemiluminescence analysis diagnosis method in the prior art.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (6)
1. An air suction and air discharge preventing method for a chemiluminescence analyzer is characterized by comprising the following steps of:
step 10, setting a preset attenuation slope of a liquid level detection waveform and a preset amplitude of the liquid level detection waveform for a processor;
step 20, when the sampling needle detects the liquid level, the processor starts timing;
step 30, when the liquid level detection waveform attenuation slope is smaller than the preset attenuation slope and the liquid level detection waveform amplitude is smaller than the preset amplitude, stopping timing by the processor and recording timing time;
step 40, when the timing time is less than or equal to 1.1s, the processor judges that the sample suction of the sampling needle is normal, and when the timing time is more than 1.1s, the processor judges that the sampling needle is sucked in an empty mode;
the stock layout comprises the following steps: step 100, setting a preset amplitude value of a liquid level detection waveform for the processor;
200, when the sampling needle performs sampling, the processor acquires a liquid level detection waveform;
and 300, when the liquid level detection waveform is larger than or equal to the preset amplitude, the processor judges that the sample discharge of the sampling needle is normal, and when the liquid level detection waveform is smaller than the preset amplitude, the processor judges that the sample discharge of the sampling needle is empty.
2. The method for preventing suction and discharge by using a chemiluminescent analyzer according to claim 1 wherein in step 20: and when the liquid level cannot be detected by the sampling needle, the amplitude of the liquid level detection waveform is smaller than the preset amplitude, and the sample suction is stopped at the moment.
3. The method for preventing suction and discharge by using a chemiluminescent analyzer according to claim 1 wherein in step 30: and when the liquid level detection waveform attenuation slope is greater than or equal to the preset attenuation slope or the liquid level detection waveform amplitude is greater than or equal to the preset amplitude, the processor continues timing and collects the liquid level detection waveform signals again.
4. The method for preventing suction and discharge by using a chemiluminescent analyzer of claim 1 further comprising the step 50: and after the processor judges that the sampling needle is empty and sucked, the processor sends an error signal.
5. The method for preventing suction and discharge by using a chemiluminescent analyzer of claim 1 further comprising the step 400: and after the processor judges that the sampling needle is empty, the processor sends out an error signal.
6. The method of claim 4 or 5, wherein the chemiluminescence analyzer further comprises an alarm for receiving the error signal and emitting an alarm.
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| CN201910542105.2A CN110221090B (en) | 2019-06-21 | 2019-06-21 | Air suction and air discharge preventing system and method applying chemiluminescence analyzer |
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| CN201910542105.2A CN110221090B (en) | 2019-06-21 | 2019-06-21 | Air suction and air discharge preventing system and method applying chemiluminescence analyzer |
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| CN110221090A CN110221090A (en) | 2019-09-10 |
| CN110221090B true CN110221090B (en) | 2021-03-23 |
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| CN111141919B (en) * | 2019-12-23 | 2021-04-09 | 苏州长光华医生物医学工程有限公司 | Reagent liquid level height detection method and device for chemiluminescence immunoassay analyzer |
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| JP2007240329A (en) * | 2006-03-08 | 2007-09-20 | Olympus Corp | Dispensing device |
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| CN101308158A (en) * | 2007-05-15 | 2008-11-19 | 株式会社日立高新技术 | Liquid separate injection device |
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| CN107250805A (en) * | 2015-02-23 | 2017-10-13 | 株式会社日立高新技术 | Automatic analysing apparatus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017008249A1 (en) * | 2015-07-14 | 2017-01-19 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling mechanism, skipped-vacuum testing method therefor, and sample analyzer |
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| EP0526210A1 (en) * | 1991-08-01 | 1993-02-03 | Toa Medical Electronics Co., Ltd. | Apparatus for detecting bubbles in reagent pipetting apparatus |
| JP2007240329A (en) * | 2006-03-08 | 2007-09-20 | Olympus Corp | Dispensing device |
| JP2007315984A (en) * | 2006-05-29 | 2007-12-06 | Hitachi High-Technologies Corp | Automatic analyzer |
| CN101308158A (en) * | 2007-05-15 | 2008-11-19 | 株式会社日立高新技术 | Liquid separate injection device |
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| CN107250805A (en) * | 2015-02-23 | 2017-10-13 | 株式会社日立高新技术 | Automatic analysing apparatus |
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