CN110220894B - Domestic medical science detects paper handkerchief - Google Patents
Domestic medical science detects paper handkerchief Download PDFInfo
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- CN110220894B CN110220894B CN201910566661.3A CN201910566661A CN110220894B CN 110220894 B CN110220894 B CN 110220894B CN 201910566661 A CN201910566661 A CN 201910566661A CN 110220894 B CN110220894 B CN 110220894B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
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- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
The invention provides a household medical detection paper towel which comprises a wiping layer, a sample penetrating layer, a reagent layer, a light transmitting layer and a skin-friendly layer, wherein the wiping layer, the sample penetrating layer, the reagent layer and the skin-friendly layer are all provided with uniformly arranged through holes, a single round central through hole of the sample penetrating layer is also provided with a bulge communicated with the wiping layer, a channel for storing a sample can be formed after the sample is folded, the amount of the sample penetrating into the reagent layer can be controlled, an accurate detection result can be obtained, and the pollution of the sample by the external environment can be avoided. The household medical detection paper towel can detect various samples and detection items, is carried about and used immediately, and breaks through the limitation of the application environment of the traditional detection test paper.
Description
Technical Field
The invention relates to the technical field of biomedical detection, in particular to a household medical detection paper towel.
Background
Currently, methods for detecting the presence or amount of a certain component in a human body, tears, saliva, urine, feces, etc. include dry chemistry and immunofluorescence. Correspondingly, the test paper combining dry chemical detection and immunofluorescence detection comprises dry chemical test paper and immunofluorescence test paper.
The dry chemical test paper has the characteristics of convenient use, simple operation and quick result output. The dry chemical test paper can be divided into a plurality of types according to the flowing path of the detection liquid sample on the dry chemical test paper, and the longitudinal vertical detection test paper is one of the dry chemical test paper. The longitudinal vertical test paper comprises carriers with reaction reagents which are mutually overlapped, and a liquid sample flows through each reaction reagent layer from top to bottom to finally display a test result.
However, the existing dry chemical test paper and immunofluorescence test paper can only be generally applied to specific experimental environments such as hospitals and laboratories, and cannot be used in any place. The invention provides a household detection tissue which is not limited by environment and can be conveniently used in any place.
Disclosure of Invention
The invention aims to provide a household detection paper towel, which solves the problem that the detection of the conventional test paper is limited by the environment, so that the detection paper towel can be used in any place immediately.
In order to achieve the above object, the present invention provides the following technical solutions:
the utility model provides a domestic medical science detects paper handkerchief, its characterized in that, includes wipes layer, reagent layer and euphotic layer, the reagent layer sets up wipe the layer with between the euphotic layer, be provided with the crease that can the fifty percent discount on the symmetry axis of detecting the paper handkerchief.
Further, the detection paper handkerchief still includes and passes through a kind layer, it sets up to pass through a kind layer wipe the layer with between the reagent layer, wipe the layer, pass through a kind layer and reagent layer and close the skin layer and all opened a plurality of through-holes in same position, the through-hole comprises three at least and constitutes a set ofly.
Furthermore, each group of through holes comprises a hollow bulge arranged between a central hole and the central hole of the wiping layer, and the inner diameter of the bulge is not less than that of the central hole.
Furthermore, a hollow bulge is arranged on a center hole of the sample permeation layer, and the inner diameter of the bulge is not smaller than that of the center hole of the wiping layer.
Further, the other side of the euphotic layer is also provided with a skin-friendly layer, and the wiping layer and the skin-friendly layer are both made of common fiber paper.
Furthermore, the material of the sample permeable layer is one of polypropylene, polyethylene, polystyrene, polyester film and poly starch.
Further, the material of the light-transmitting layer is one of polypropylene, polyethylene, polystyrene, polyester film and poly starch.
Furthermore, the material of the reagent layer is biochemical reaction test paper, and the reagent of the reagent layer is one or more of dry chemical reaction reagent, chromatography reagent, nucleic acid reagent, antibody and small molecule compound detection reagent.
Further, the household medical detection paper towel is manufactured by a pressing method.
The invention has the beneficial effects that:
the household medical detection paper towel is provided with the foldable crease in the direction of the wiping layer, so that after an object to be detected is wiped, the paper towel is folded to enable the pore passages on the left side and the right side to be superposed, a sample to be detected is stored in the pore passages, the wiping layer is protected from external pollution, and the transportation and the storage are convenient.
The household medical detection paper towel provided by the invention has a five-layer structure and has the functions of collection, sample penetration, detection and isolation. Need not strictly control sample volume when using, after gathering the sample, will detect the paper handkerchief fifty percent discount, the arch of setting on penetrating the appearance layer can form a passageway of the sample of being convenient for preserve and the sample volume of control infiltration reagent layer after folding, reaches the purpose of quick accurate detection sample.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive exercise.
FIG. 1 is a schematic view of the structure of the household medical test paper towel of the present invention.
FIG. 2 is a cross-sectional view of a home medical test paper towel of the present invention.
FIG. 3 is a schematic view of a set of through holes of a home medical test paper towel according to the present invention.
Wherein, 1-wiping layer, 2-sample permeable layer, 3-reagent layer, 4-euphotic layer, 5-skin-friendly layer, 6-through hole, 61-center hole, 7-bulge and 8-crease.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention aims to provide a household medical detection paper towel, which solves the problems in the prior art and enables the medical detection paper towel to be conveniently used in any place.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
Example one
As shown in fig. 1-3, the present embodiment provides a household medical detection paper towel, which specifically includes a wiping layer 1, a light-pervious layer 4, and a reagent layer 3 disposed between the wiping layer 1 and the light-pervious layer 4, further, a sample-pervious layer 2 is disposed between the wiping layer 1 and the reagent layer 3, and a skin-friendly layer 5 is disposed on the other side of the light-pervious layer 4. The wiping layer 1 and the skin-friendly layer 5 are made of common fiber paper, the sample permeable layer 2 is made of polypropylene material, the euphotic layer 4 is made of polystyrene material, and the reagent layer 3 is biochemical reaction test paper.
As shown in figure 2, a plurality of through holes 6 are formed in the wiping layer 1, the sample permeable layer 2, the reagent layer 3 and the skin-friendly layer 5 at the same positions, wherein the through holes 6 of the wiping layer 1 are sample collecting holes, and the sample is rapidly flowed to the sample permeable layer 2 through the collecting holes in the wiping layer 1. The through hole 6 of the sample permeation layer 2 is a sample permeation hole, and the sample transmitted from the collection hole is further transmitted to the reagent layer 3. The through-hole 6 of the reagent layer 3 is a detection hole for the sample, and the sample reaching the detection hole is allowed to react with the reagent around the hole. An observation hole is arranged on the outermost skin-friendly layer 5, and the reaction phenomenon of the reagent layer 3 can be observed through the through hole 6 to judge the detection result.
The through holes 6 of the present embodiment are grouped by 9 as shown in fig. 1 and 3. A central hole 61 is formed in the center of each group of through holes 6 of each layer, a hollow bulge 7 is arranged on the central hole 61 of the sample permeation layer 2, the inner diameter of the bulge 7 is 1.5:1 of the hole diameter of the through hole 6, and the bulge is communicated with the central hole 61 of the wiping layer 1. After the detection paper towel is folded in half, the bulges 7 on the two sides of the symmetry axis can form a closed pore channel for the sample to flow through, the pore channel can store the sample to be detected so that the sample is not polluted by the environment, and the amount of the sample reaching the detection hole can be controlled through the pore channel, thereby avoiding the problem that the liquid diffusion is uncontrollable due to the fact that the liquid is too much and directly soaks the reagent layer 3 through the paper layer, and further causing the inaccurate detection result.
As shown in figure 1, the household medical detection paper towel has 8 groups of through holes 6, 4 groups of through holes are distributed on the left and the right respectively and are symmetrically arranged, wherein a crease 8 is arranged on the part of the symmetry axis, and after the paper towel to be detected wipes a sample, the detection paper towel is folded in half by the arranged crease 8 for storage.
After the wiping layer 1 collects a sample, the sample to be detected permeates the sample penetrating layer 2 through the through hole 6 in the wiping layer 1 and enters the reagent layer 3 through the sample penetrating hole, the sample reacts with the reagent on the reagent layer 3 and is blocked by the non-porous euphotic layer 4, and the skin-friendly layer 5 is prevented from being permeated to cause pollution. After the sample is collected, the detection paper towel is folded in half through the crease 8, and the through holes 6 of the left and right paper towels can be overlapped due to the symmetrical structure after the folding. Because the hollow bulges 7 are arranged between the wiping layer 1 and the sample permeable layer 2, the bulges 7 at the left side and the right side can be closed to form a closed pore channel after being folded, the sample can be completely stored in the pore channel, and the detection paper towel is prevented from being influenced by the environment and polluting the sample during storage and transportation. The sample amount of the sample penetrating into the reagent layer 3 can be controlled through the bulges 7, and the direct water seepage of the reagent layer 3 caused by excessive sample amount is avoided, so that the detection result is not influenced. After the sample reacts on the reagent layer 3, the euphotic layer 4 is made of a material which is light-transmitting and water-proof, so that the liquid sample can be blocked to the euphotic layer 4 without continuously permeating to the skin-friendly layer 5, and after the detection result is displayed, a user can record the detection result through the observation hole in the skin-friendly layer 5 by penetrating the euphotic layer 4. In the process of storing and transporting the detection paper towel, the common fiber paper of the skin-friendly layer 5 can increase the friction force between the detection paper towel and hands or other clamping tools, so that the detection paper towel is stably transported and is not easy to slip off.
Compared with the traditional detection test paper with a single-layer structure, the detection paper provided by the invention is of a multi-layer structure, and the through holes 6 are formed in a specific layer. The traditional test paper needs experimenters to reasonably control the amount of a sample to be detected, and if the amount of the sample is too much, the traditional test paper is excessively soaked, so that the detection result is inevitably influenced. The detection paper towel provided by the invention can control the sample to flow into the reagent layer 3 through the holes at a first speed through the arrangement of the through holes 6, and excessive sample can be retained in the non-porous part of each layer of test paper through transverse permeation so as to regulate and control the influence of the sample amount on the detection result. Moreover, when the sample amount is too large, the protrusion 7 between the wipe layer 1 and the sample permeation layer 2 is equivalent to a channel through which the liquid can flow, and the sample amount reaching the reagent layer 3 can be controlled through the channel. If the amount of the sample is too small, the sample on the traditional test paper is not enough to react with the reagent, or the reaction phenomenon is not obvious. However, the detection paper towel provided by the invention has the through holes 6 which are directly communicated with the reagent layer 3, so that the speed of the sample flowing to the reagent layer 3 through the holes is higher than the speed of the sample permeating to the reagent layer 3 layer by layer, and even if the sample amount is too small, the sample can be directly contacted with the reagent layer 3 through the holes, thereby realizing the purpose of rapid detection.
The principle and the implementation mode of the invention are explained by applying a specific example, and the description of the embodiment is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the invention.
Claims (6)
1. The household medical detection tissue is characterized by comprising a wiping layer, a sample permeable layer, a reagent layer, a light permeable layer and a skin-friendly layer, wherein the sample permeable layer is arranged between the wiping layer and the reagent layer, the reagent layer is arranged between the sample permeable layer and the light permeable layer, and the skin-friendly layer is arranged on the other side of the light permeable layer; creases capable of being folded in half are arranged on the symmetry axis of the detection paper towel;
the wiping layer, the sample permeation layer and the reagent layer are provided with a plurality of through holes at the same positions, and the through holes at least comprise three through holes in one group; after wiping the object to be tested, folding the paper towel to enable the pore passages on the left side and the right side to be superposed, and storing the sample to be tested in the pore passages;
each group of through holes comprises a central hole, and a plurality of groups of through holes are distributed on the detection paper towel in a matrix manner;
a hollow bulge is arranged between the central hole of the sample permeation layer and the central hole of the wiping layer; an aperture ratio of an inner diameter of the protrusion to an inner diameter of the through hole is 1.5: 1;
the euphotic layer is made of a material which is light-transmitting and water-proof, and can block the liquid sample from the euphotic layer without continuously permeating the skin-friendly layer.
2. The household medical test paper towel according to claim 1, wherein the wiping layer and the skin-friendly layer are both made of common fiber paper;
the skin-friendly layer is provided with an observation hole, and the detection result is recorded through the observation hole in the skin-friendly layer.
3. The household medical test paper towel of claim 1, wherein the material of the sample permeable layer is one of polypropylene, polyethylene, polystyrene, mylar and poly starch.
4. The household medical detection paper towel according to claim 1, wherein the material of the light-transmitting layer is one of polypropylene, polyethylene, polystyrene, polyester film and poly-starch.
5. The household medical detection paper towel according to claim 1, wherein the reagent layer is made of a biochemical reaction test paper, and the reagent of the reagent layer is one or more of a dry chemical reaction reagent, a chromatography reagent, a nucleic acid reagent, an antibody reagent and a small molecule compound detection reagent.
6. The method for preparing a household medical test paper towel according to claim 1, wherein the test paper towel is prepared by a pressing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566661.3A CN110220894B (en) | 2019-06-27 | 2019-06-27 | Domestic medical science detects paper handkerchief |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910566661.3A CN110220894B (en) | 2019-06-27 | 2019-06-27 | Domestic medical science detects paper handkerchief |
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| CN110220894A CN110220894A (en) | 2019-09-10 |
| CN110220894B true CN110220894B (en) | 2021-10-08 |
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| CN201910566661.3A Active CN110220894B (en) | 2019-06-27 | 2019-06-27 | Domestic medical science detects paper handkerchief |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113049575B (en) * | 2021-02-23 | 2023-05-16 | 深圳职业技术学院 | Medicine detection device and system |
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| CN207081663U (en) * | 2017-08-02 | 2018-03-09 | 天津果实科技有限公司 | A kind of miniature urinalysis test paper |
| CN109044166A (en) * | 2018-10-19 | 2018-12-21 | 医芯（厦门）科技有限公司 | Paper handkerchief and preparation method thereof with pH detection function |
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2019
- 2019-06-27 CN CN201910566661.3A patent/CN110220894B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2725897Y (en) * | 2004-08-20 | 2005-09-14 | 北京金域高科诊断技术有限公司 | Folding trepanning standard colorimetric board |
| FI123297B (en) * | 2009-05-04 | 2013-02-15 | Valtion Teknillinen | Lateral flow test strip and its manufacturing method |
| CN102128918A (en) * | 2010-11-11 | 2011-07-20 | 艾康生物技术(杭州)有限公司 | Detecting test paper |
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