CN110218643B - Magnetic stirring system with weighing function - Google Patents
Magnetic stirring system with weighing function Download PDFInfo
- Publication number
- CN110218643B CN110218643B CN201910529962.9A CN201910529962A CN110218643B CN 110218643 B CN110218643 B CN 110218643B CN 201910529962 A CN201910529962 A CN 201910529962A CN 110218643 B CN110218643 B CN 110218643B
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- weighing
- stirring
- main body
- closed environment
- fixing ring
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- 238000005303 weighing Methods 0.000 title claims abstract description 115
- 238000003760 magnetic stirring Methods 0.000 title claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 58
- 230000005540 biological transmission Effects 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 238000004113 cell culture Methods 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 5
- 238000005259 measurement Methods 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 7
- 239000011229 interlayer Substances 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
Landscapes
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
Abstract
The invention provides a magnetic stirring system with a weighing function, which at least comprises: a stirring assembly; the transmission assembly is used for transmitting to the stirring bracket; a weighing body; a load cell assembly. The magnetic stirring system with the weighing function can monitor the quality change of the liquid to be measured while stirring, is particularly suitable for cell culture, is stable and not easy to shake, can directly perform continuous measurement and stirring in a closed environment, does not influence the temperature, humidity and gas concentration parameters of the closed space, does not occupy the space in the closed environment, is convenient to assemble, has low cost and is easy to replace parts. The time of exposing the cells to be detected in the adverse environment can be reduced, and the culture efficiency and the culture effect can be improved.
Description
Technical Field
The invention relates to the field of stirring instruments, in particular to a magnetic stirring system with a weighing function.
Background
A magnetic stirrer is an instrument for stirring a liquid or a solid-liquid mixture having a low viscosity. The magnetic stirrer utilizes the characteristic that like poles of magnetic substances repel each other, and the polarities at the two ends of the base are continuously changed to drive the magnetic stirrer to rotate, so that the stirred objects are uniformly mixed by driving the stirred objects to rotate through the rotation of the magnetic stirrer.
Magnetic stirring techniques are often used in the biomedical industry, for example, in cell culture, where the culture medium needs to be stirred to ensure good growth of the cells. However, in some cell cultures, besides stirring, the weight of the cells needs to be monitored, at least two instruments, namely a magnetic stirrer and an electronic balance, are needed in the existing method, a stable culture environment is often needed in cell culture, two instruments are respectively used, the time of exposing the cells in adverse environments can be increased during operation, and the real-time monitoring of the cell quality cannot be achieved, so that the culture efficiency and the culture effect are greatly reduced.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, an object of the present invention is to provide a magnetic stirring system with weighing function.
To achieve the above and other related objects, the present invention provides a magnetic stirring system with a weighing function, at least comprising:
the stirring assembly comprises a stirring bracket, the top end of the stirring bracket is provided with a magnetic field generating assembly, the stirring bracket is provided with a weighing main body accommodating area, at least the top end of the weighing main body accommodating area is open, the stirring assembly is provided with a first wire passing through hole, and the first wire passing through hole is communicated with the weighing main body accommodating area;
the transmission assembly is arranged below the stirring bracket and is used for transmitting to the stirring bracket; the transmission assembly is provided with a second wire passing through hole which is coaxial and communicated with the first wire passing through hole;
the weighing module comprises:
the weighing main body is arranged in the weighing main body accommodating area, and is not contacted with the stirring bracket and the magnetic field generating component;
the weighing sensing component is arranged on the weighing main body and is connected with a cable, and the cable passes through the first wire passing through hole and the second wire passing through hole and penetrates out of the stirring module.
As described above, the magnetic stirring system with the weighing function has the following beneficial effects:
the magnetic stirring system with the weighing function can monitor the quality change of the liquid to be measured while stirring, is particularly suitable for cell culture, is stable and not easy to shake, can directly perform continuous measurement and stirring in a closed environment, does not influence the temperature, humidity and gas concentration parameters of the closed space, does not occupy the space in the closed environment, is convenient to assemble, has low cost and is easy to replace parts. The time of exposing the cells to be detected in the adverse environment can be reduced, and the culture efficiency and the culture effect can be improved.
Drawings
Fig. 1 shows a schematic structure of a magnetic stirring system with a weighing function according to the present invention.
Fig. 2 shows a front view of a stirring module of the magnetic stirring system with a weighing function.
Fig. 3 shows a top view of a stirring module of the magnetic stirring system with a weighing function.
Fig. 4 shows a bottom view of a stirring module of the magnetic stirring system with a weighing function according to the invention.
Fig. 5 shows a front view of a weighing module of the magnetic stirring system with weighing function according to the invention.
FIG. 6 is a schematic diagram of a weighing tray and a load cell component of the magnetic stirring system with weighing function of the present invention.
Fig. 7 shows a schematic view of the magnetic stirring system with weighing function of the present invention mounted to a closed environment.
Description of element reference numerals
1. Stirring support
11. Magnetic field generating assembly
111. First magnetic block
112. Second magnetic block
12. Weighing main body accommodating area
13. First via hole
14. First support
15. Second support
16. Bracket main body
2. Transmission assembly
21. Second via hole
22. Rotary shaft
23. First transmission block
24. Second transmission block
3. Weighing main body
4. Weighing sensor component
41. Cable with improved heat dissipation
5. Power assembly
6. Weighing tray
7. Weighing fixing ring
71. Inner side fixing ring of closed environment
72. Outside fixing ring for closed environment
73. Second gap
8. First slit
9. Shell body
91. Shell through wire via
Detailed Description
Further advantages and effects of the present invention will become apparent to those skilled in the art from the disclosure of the present invention, which is described by the following specific examples.
Please refer to fig. 1 to 7. It should be understood that the structures, proportions, sizes, etc. shown in the drawings are for illustration purposes only and should not be construed as limiting the invention to the extent that it can be practiced, since modifications, changes in the proportions, or otherwise, used in the practice of the invention, are not intended to be critical to the essential characteristics of the invention, but are otherwise, required to achieve the objective and effect taught by the invention. Also, the terms such as "upper," "lower," "left," "right," "middle," and "a" and the like recited in the present specification are merely for descriptive purposes and are not intended to limit the scope of the invention, but are intended to provide relative positional changes or modifications without materially altering the technical context in which the invention may be practiced.
As shown in fig. 1 and 2, the present invention provides a magnetic stirring system with a weighing function, which at least includes:
the stirring assembly comprises a stirring bracket 1, wherein a magnetic field generating assembly 11 is arranged at the top end of the stirring bracket, a weighing main body accommodating area 12 is formed on the stirring bracket, at least the top end of the weighing main body accommodating area 12 is open, the stirring assembly is provided with a first wire passing through hole 13, and the first wire passing through hole 13 is communicated with the weighing main body accommodating area 12 (see figure 3);
the transmission assembly 2 is arranged below the stirring bracket 1 and is used for transmitting to the stirring bracket; the transmission assembly 2 is provided with a second wire passing through hole 21, and the second wire passing through hole 21 is coaxial with and communicated with the first wire passing through hole 13;
the weighing module comprises:
the weighing main body 3 is arranged in the weighing main body accommodating area 12, and the weighing main body 3 is not contacted with the stirring bracket 1 and the magnetic field generating component 11;
the weighing sensor part 4 (see fig. 6) is arranged on the weighing main body 1, a cable 41 is connected to the weighing sensor part 4, and the cable 41 passes out of the stirring module through the first wire through hole 13 and the second wire through hole 21.
The magnetic field generating assembly is used for generating a rotating magnetic field.
Further, the stirring module further comprises a power assembly 5 connected with the transmission assembly 2 and used for providing rotary power for the stirring assembly.
In one embodiment, the power assembly is an electric motor.
In one embodiment, the motor is a 42bygh34 motor.
In one embodiment, the stirring rack 1 is hollow. The weight of the stirring bracket can be reduced, the material is saved, the load is reduced, and the energy consumption is reduced.
In one embodiment, as shown in fig. 2, the transmission assembly includes:
a rotation shaft 22 connected to the stirring bracket 1 and used for driving the stirring bracket to rotate, wherein the second wire passing through hole 21 is arranged in the rotation shaft;
the first transmission block 23 is connected with the rotating shaft 22 and is used for driving the rotating shaft 22 to rotate;
and the second transmission block 24 is respectively connected with the first transmission block 23 and the power assembly 5 and is used for transmitting between the power assembly and the first transmission block 23.
The rotation center shaft of the stirring bracket is coaxial with the rotation shaft.
The bottom end opening of the rotating shaft enables the cable or the conduit in the second wire passing through hole to extend out.
In one embodiment, the first transmission block 23 includes a first gear and the second transmission block 24 includes a second gear, the first and second gears being meshed with each other.
In one embodiment, the motor is provided with a rotating shaft, and the second gear is connected with the rotating shaft and rotates together with the rotating shaft.
In one embodiment, the magnetic field generating assembly includes a first magnetic block 111 and a second magnetic block 112, the first magnetic block 111 and the second magnetic block 112 being symmetrically distributed with respect to the rotation axis.
In one embodiment, the stirring rack includes a first rack 14, a second rack 15, and a rack main body 16, where the first rack 14 and the second rack 15 are respectively connected to the rack main body 16, and are disposed on top of the first rack 112 with the first magnetic block 111, the second magnetic block 22 is disposed on top of the second rack 15, and the first wire passing through hole 13 is disposed on the rack main body 16.
In one embodiment, the first bracket 14 and the second bracket 15 are perpendicular to the bracket main body 16, respectively.
The first brackets 14 and the second brackets 15 extend in the same direction.
In one embodiment, the first magnetic block 111 and the second magnetic block 112 are permanent magnets.
Further, as shown in fig. 5, the weighing module further includes:
the weighing tray 6 is arranged above the weighing main body 3 and connected with the top of the weighing main body 3, and the weighing tray 6 is connected with the weighing sensing component 4.
In one embodiment, as shown in fig. 6, the load cell member 4 is disposed at the bottom of the weighing tray, and the weighing body is disposed at the bottom of the load cell member.
The weighing tray, the weighing sensing component and the weighing main body can also adopt a connection mode in the prior art, and only the weighing function can be realized.
In one embodiment, the weighing tray 6 is detachably connected to the weighing body 3. Can be replaced as required to conform to the fit of the measuring instrument.
In one embodiment, as shown in fig. 5, the weighing module further comprises:
the weighing module further comprises: and the weighing fixing ring 7 is nested on the outer side wall of the weighing main body and is used for fixing the weighing module to a device capable of realizing a closed environment, and the upper part of the weighing main body 1 is positioned in the closed environment by taking the weighing fixing ring 4 as a boundary, and the lower part of the weighing main body 1 is positioned outside the closed environment.
The enclosed environment may be an enclosed box. The whole box body environment is in a relatively closed state and is communicated with the outside only through a passage on the box body, and the box body is relatively independent of the outside environment, so that the environment in the box body is in a controllable range.
After the weighing sensor is tightly connected with the closed environment, the sealing property of the closed environment is not damaged, and the cleanliness is not damaged. Only a part of the main body and the tray are left in the box body, so that the space in the closed environment is saved.
A first gap 8 is arranged between the weighing tray 6 and the weighing fixing ring 7. The tray can not touch the fixed ring during measurement, and the accuracy of measurement data is guaranteed.
In one embodiment, as shown in fig. 5, the weighing fixing ring 7 includes an enclosed-environment inside fixing ring 71 and an enclosed-environment outside fixing ring 72; the closed environment inner fixing ring 71 is arranged above the closed environment outer fixing ring 72, and a second gap 73 is arranged between the closed environment inner fixing ring 71 and the closed environment outer fixing ring 72; the closed environment inside fixing ring 71 is used for fixing the weighing body 3 inside the closed environment; the closed environment outside fixing ring 72 is used for fixing the weighing body 3 outside the closed environment.
The second gap is matched with the thickness of the interlayer of the closed environment. The interlayer is a laminate for separating the enclosed environment from the outside to form a relatively independent space.
Furthermore, the position of the fixing ring outside the closed environment is adjustable, and the fixing ring is used for being suitable for mounting positions with different thicknesses.
In one embodiment, the closed environment inside securing ring is a flange.
In one embodiment, the closed environment outside fixation ring 42 is a lock nut.
In one embodiment, the weighing fixing ring is provided with a sealing gasket, and the sealing gasket is arranged on one side of the sealing environment outside fixing ring, which is fixed with the sealing environment. For enhancing the closure.
In one embodiment, the sensing element 3 is a pressure sensor.
In one embodiment, the system further comprises a magnetic stirrer for placement within the liquid to be stirred.
As shown in fig. 4, the magnetic stirring system with the weighing function further comprises a shell 9, and a shell wire through hole 91 is formed in the shell 9. The housing through-wire via is for passing a cable or conduit in the second through-wire via. And enabling a cable or a pipeline extending on the container to extend out of the magnetic stirring system with the weighing function.
The shell can be provided with a controller for controlling the rotating speed of the motor. And further controlling the rotating speed of the magnetic stirring system with the weighing function.
The controller can be realized by using the prior art. For example, the controller may be a single-chip microcomputer, and the single-chip microcomputer may be an 8-bit minimum system. The controller may also be selected from different brands and models, or a higher-order controller or processor. The motor rotation speed can be controlled.
The shell is provided with a mounting block, so that the stirring module can be fixedly mounted on the interlayer of the closed environment.
In one embodiment, the shell may also be provided with a storage board, and the weighing module is fixed on the storage board, so that stirring and weighing are performed simultaneously.
When the magnetic stirring system is used, as shown in fig. 7, the weighing module and the stirring module are respectively fixed on the interlayer of the closed environment, and the cable on the weighing module sequentially passes through the first wire passing through hole, the second wire passing through hole and the shell wire passing through hole and stretches out of the magnetic stirring system with the weighing function. The method comprises the steps of placing a container containing a mixture to be stirred and weighed on a weighing tray on the other side of the interlayer, placing a magnetic stirrer in the container, starting a power assembly, sequentially driving a second transmission block, a first transmission block, a rotating shaft, a stirring support and a magnetic field generating assembly to rotate, generating a rotating magnetic field, driving the magnetic stirrer in the container to rotate, driving a stirred object to rotate, and enabling the stirred object to be uniformly mixed. And meanwhile, the weight can be weighed through the weighing module.
The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. Modifications and variations may be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.
Claims (5)
1. Magnetic stirring system with weighing function, characterized in that it comprises at least a stirring module and a weighing module, said stirring module comprising:
the stirring assembly comprises a stirring bracket (1), a magnetic field generating assembly (11) is arranged at the top end of the stirring bracket, a weighing main body accommodating area (12) is formed on the stirring bracket, at least the top end of the weighing main body accommodating area (12) is open, a first wire passing through hole (13) is formed in the stirring assembly, and the first wire passing through hole (13) is communicated with the weighing main body accommodating area (12);
the transmission assembly (2) is arranged below the stirring bracket (1) and is used for transmitting to the stirring bracket; the transmission assembly (2) is provided with a second wire passing through hole (21), and the second wire passing through hole (21) is coaxial and communicated with the first wire passing through hole (13);
the weighing module comprises: the weighing main body (3) is arranged in the weighing main body accommodating area (12), and the weighing main body (3) is not contacted with the stirring bracket (1) and the magnetic field generating assembly (11);
the weighing sensing component (4) is arranged on the weighing main body (1), a cable (41) is connected to the weighing sensing component (4), and the cable (41) passes through the first wire passing through hole (13) and the second wire passing through hole (21) and penetrates out of the stirring module;
the magnetic field generating assembly comprises a first magnetic block (111) and a second magnetic block (112), and the first magnetic block (111) and the second magnetic block (112) are symmetrically distributed relative to a rotation axis;
the weighing tray (6) is arranged above the weighing main body (3) and connected with the top of the weighing main body (3), and the weighing tray (6) is connected with the weighing sensing component (4);
the weighing module further comprises a weighing fixing ring (7) which is nested on the outer side wall of the weighing main body and used for fixing the weighing module to a device capable of realizing a closed environment, the upper part of the weighing main body (1) is positioned in the closed environment by taking the weighing fixing ring (4) as a boundary, and the lower part of the weighing main body (1) is positioned outside the closed environment;
a first gap (8) is formed between the weighing tray (6) and the weighing fixing ring (7);
the weighing fixing ring (7) comprises a closed environment inner fixing ring (71) and a closed environment outer fixing ring (72); the closed environment inner side fixing ring (71) is arranged on the closed environment outer side fixing ring (72), and a second gap (73) is formed between the closed environment inner side fixing ring (71) and the closed environment outer side fixing ring (72); the closed environment inner side fixing ring (71) is used for fixing the weighing main body (3) at the inner side of the closed environment; the closed environment outside fixing ring (72) is used for fixing the weighing main body (3) outside the closed environment.
2. A magnetic stirring system with weighing function as claimed in claim 1, characterized in that the stirring module further comprises a power assembly (5) connected to the transmission assembly (2) for providing rotary power to the stirring assembly.
3. The magnetic stirring system with weighing function of claim 2, wherein the transmission assembly comprises:
the rotating shaft (22) is connected with the stirring bracket (1) and used for driving the stirring bracket to rotate, and the second wire passing through hole (21) is arranged in the rotating shaft;
the first transmission block (23) is connected with the rotating shaft (22) and is used for driving the rotating shaft (22) to rotate;
and the second transmission block (24) is respectively connected with the first transmission block (23) and the power assembly (5) and is used for transmitting between the power assembly and the first transmission block (23).
4. A magnetic stirring system with weighing function as claimed in claim 3, characterized in that the first transmission block (23) comprises a first gear and the second transmission block (24) comprises a second gear, the first and second gears being mutually meshed.
5. The magnetic stirring system with weighing function of claim 1, further comprising a magnetic stirrer for placement within the liquid to be stirred.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910529962.9A CN110218643B (en) | 2019-06-19 | 2019-06-19 | Magnetic stirring system with weighing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910529962.9A CN110218643B (en) | 2019-06-19 | 2019-06-19 | Magnetic stirring system with weighing function |
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| Publication Number | Publication Date |
|---|---|
| CN110218643A CN110218643A (en) | 2019-09-10 |
| CN110218643B true CN110218643B (en) | 2024-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910529962.9A Active CN110218643B (en) | 2019-06-19 | 2019-06-19 | Magnetic stirring system with weighing function |
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| CN (1) | CN110218643B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114034363B (en) * | 2021-10-13 | 2024-05-03 | 上海唐颐集谱生物细胞技术有限公司 | Weighing device and method |
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| CN109825436A (en) * | 2019-03-12 | 2019-05-31 | 华道(上海)生物医药有限公司 | Totally-enclosed cell culture system |
| CN210314266U (en) * | 2019-06-19 | 2020-04-14 | 华道(上海)生物医药有限公司 | Magnetic stirring system with weighing function |
-
2019
- 2019-06-19 CN CN201910529962.9A patent/CN110218643B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2926238Y (en) * | 2006-03-30 | 2007-07-25 | 杜乃融 | Self-suction flange fermenter |
| KR100799988B1 (en) * | 2006-11-30 | 2008-01-31 | 연세대학교 산학협력단 | The bio-reactor which exerts various mechanical stimula for nurturing of stem cell and the method of nuturing of stem cell which uses it |
| CN204485736U (en) * | 2015-03-06 | 2015-07-22 | 大连神华轻工机械有限公司 | A kind of magnetic agitation system with ceramic bearing magnetic stirring bar and weighing component |
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