CN110200866A - A kind of treasured Rogor nano liposomes and preparation method thereof - Google Patents
A kind of treasured Rogor nano liposomes and preparation method thereof Download PDFInfo
- Publication number
- CN110200866A CN110200866A CN201910437457.1A CN201910437457A CN110200866A CN 110200866 A CN110200866 A CN 110200866A CN 201910437457 A CN201910437457 A CN 201910437457A CN 110200866 A CN110200866 A CN 110200866A
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- rogor
- nano liposomes
- borojo
- edta
- glycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of precious Rogor nano liposomes, it is grouped as by the group of following mass percentage: octyl dodecanol 2~5.0%, glycerol 5~10%, hydrolecithin 0.5~5.0%, EDTA-2Na 0.01~0.1%, sterols 4~10%, ceteth class 2~6%, liquid fat 5~15%, Borojo 0.1~3.0%, the water of preservative 0.5~3.0% and surplus.Partial size is small, stable product quality, compatibility and good water solubility, keeps the preparation of the cosmetics containing precious Rogor convenient, simple, can under normal temperature conditions with the required any interworking of skin care item preparation.
Description
Technical field
The present invention relates to a kind of precious Rogor nano liposomes and preparation method thereof.
Background technique
Precious Rogor (Borojo) is a kind of fruit for growing unique adaptation Ecuador weather of tropical rain forest in South America,
Its fruit diameter reaches 7-12 centimetres, is green when prematurity, switchs to dark brown after mature, sour and sticky, after removing seed
Pulp weight accounts for 88%.Fresh Borojo is in acid (pH=2.74), rich in B family vitamin B1, B2, niacin, folic acid and
Vitamin E, free amino acid, microelement and linoleic acid plus linolenic acid needed by human necessary to the mankind, thus have whitening,
The effect of anti-oxidant, moisturizing, anti-inflammatory, adjusting blood glucose and strengthen immunity.Although Borojo is a kind of very high water of nutritive value
Fruit, but precious Rogor has following characteristics in practical applications: easily moisture absorption, utilization rate is not high under nonprotected state, and makes to produce
Product discoloration is spoiled thinning.
Summary of the invention
The precious stability of Rogor and the treasured of skin permeability can be improved the technical problem to be solved in the present invention is to provide a kind of
Rogor nano liposomes, the effect of property that gives full play to precious Rogor.
To solve the above problems, the present invention adopts the following technical scheme:
A kind of treasured Rogor nano liposomes, are grouped as by the group of following mass percentage: octyl dodecanol 2~5.0%,
Glycerol 5~10%, hydrolecithin 0.5~5.0%, EDTA-2Na 0.01~0.1%, sterols 4~10%, cetanol are poly-
Ethers 2~6%, liquid fat 5~15%, Borojo 0.1~3.0%, the water of preservative 0.5~3.0% and surplus.
Further, be grouped as by the group of following mass percentage: octyl dodecanol 2%, glycerol 10% hydrogenate lecithin
Rouge 5.0%, EDTA-2Na 0.1%, sterols 10%, ceteth class 6%, liquid fat 15%, Borojo 3.0%,
The water of preservative 3.0% and surplus.
Further, be grouped as by the group of following mass percentage: octyl dodecanol 5.0%, glycerol 5% hydrogenate ovum
Phosphatidase 0 .5%, EDTA-2Na 0.01%, sterols 4%, ceteth class 2%, liquid fat 5%, Borojo 0.1%,
The water of preservative 0.5% and surplus.
Further, be grouped as by the group of following mass percentage: octyl dodecanol 3%, glycerol 8% hydrogenate lecithin
Rouge 3%, EDTA-2Na 0.05%, sterols 7%, ceteth class 4%, liquid fat 9%, Borojo 1%, preservative
1% and surplus water.
Another technical problem to be solved by the present invention is that a kind of preparation method of precious Rogor nano liposomes is provided, including with
Lower step:
(1) octyl dodecanol, glycerol, water, EDTA-2Na, Borojo, preservative are configured to homogeneous solution；
(2) hydrolecithin, sterols, ceteth class and liquid fat are mixed into homogeneous solution；
(3) solution that step (1) and (2) obtain is handled by high-pressure emulsification homogenizer, high-pressure homogeneous pressure is
100bar~1000bar, cycle-index are 2 times~8 times, obtain a kind of precious Rogor nanometer of the milky partial size less than 300nm
Liposome.
The beneficial effects of the present invention are: partial size is small, stable product quality, compatibility and good water solubility, make containing precious Rogor
Cosmetics preparation it is convenient, simple, can under normal temperature conditions with the required any interworking of skin care item preparation.
Specific embodiment
Embodiment 1: by 3.0% octyl dodecanol, 6.0% glycerol, 0.02%EDTA-2Na, 0.5%Borojo, 2.0%
1,2- hexylene glycol is configured to homogeneous solution；By 1.8% hydrolecithin, 2.0% campesterol class, 2.0%PEG-5 rapeseed steroid
Alcohol, 2.0% cholesterine, 1.0% ceteth -3,1.0% ceteth -5 and 5.0% Queensland nut seed oil are mixed
To homogeneous solution；Solution obtained above is handled by high-pressure emulsification homogenizer, high-pressure homogeneous pressure is 100bar, circulation time
Number is 5 times, obtains a kind of precious Rogor nano liposomes of the double-layer structure of milky partial size 300nm.
Embodiment 2: by 2.0% octyl dodecanol, 7.0% glycerol, 0.01%EDTA-2Na, 0.5%Borojo, 2.0%
1,2- hexylene glycol is configured to homogeneous solution；By 2.0% hydrolecithin, 2.0% campesterol class, 2.0%PEG-5 rapeseed steroid
Alcohol, 3.0% cholesterine, 1.0% ceteth -3,1.0% ceteth -5 and 5.0% Queensland nut seed oil are mixed
To homogeneous solution；Solution obtained above is handled by high-pressure emulsification homogenizer, high-pressure homogeneous pressure is 600bar, circulation time
Number is 5 times, obtains a kind of precious Rogor nano liposomes of the double-layer structure of milky partial size 250nm.
Embodiment 3: by 3.0% octyl dodecanol, 8.0% glycerol, 0.01%EDTA-2Na, 1.0%Borojo, 2.0%
1,2- hexylene glycol is configured to homogeneous solution；By 2.5% hydrolecithin, 2.0% campesterol class, 2.0%PEG-5 rapeseed steroid
Alcohol, 3.0% cholesterine, 1.0% ceteth -3,1.0% ceteth -5 and 6.0% Queensland nut seed oil are mixed
To homogeneous solution；Solution obtained above is handled by high-pressure emulsification homogenizer, high-pressure homogeneous pressure is 800bar, circulation time
Number is 8 times, obtains a kind of precious Rogor nano liposomes of the double-layer structure of milky partial size 200nm.
Embodiment 4: by 5.0% octyl dodecanol, 10.0% glycerol, 0.02%EDTA-2Na, 1.5%Borojo, 3.0%
1,2- hexylene glycol is configured to homogeneous solution；By 5% hydrolecithin, 2.0% campesterol class, 2.0%PEG-5 rapeseed steroid
Alcohol, 3.5% cholesterine, 1.0% ceteth -3,2.0% ceteth -5 and 5.0% Queensland nut seed oil are mixed
To homogeneous solution；Solution obtained above is handled by high-pressure emulsification homogenizer, high-pressure homogeneous pressure is 100bar, circulation time
Number is 6 times, obtains a kind of precious Rogor nano liposomes of the double-layer structure of milky partial size 150nm.
Treasured Rogor nano liposomes of the present invention, can protect precious Rogor not aoxidized by extraneous factor, improve precious happy
The stability and skin permeability of fruit sufficiently increase precious Rogor the effect of property.
Experimental example:
One Application Example of treasured Rogor nano liposomes of the invention, is formulated as follows:
Control group 1: precious Rogor is not added；Control group 2: 0.2% precious Rogor powder is added；Experimental group table as above
1, moistening effect is tested
As seen from the above table, compared with the control group, the performance of keeping humidity that the formula of precious Rogor is not added is general for experimental group, is added
The formula moisture retention of precious Rogor is obvious, illustrates that precious Rogor has the effect of moisturizing to skin, and same amount of precious Rogor is added, warp
Precious Rogor, that is, experimental group after nano liposomes package, moistening effect become apparent, and illustrate that it has synergistic effect to moisture retention.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the scope of protection of the present invention.
Claims (4)
1. a kind of treasured Rogor nano liposomes, it is characterised in that: be grouped as by the group of following mass percentage: octyl dodecanol
2~5.0%, glycerol 5~10%, hydrolecithin 0.5~5.0%, EDTA-2Na 0.01~0.1%, sterols 4~10%,
Ceteth class 2~6%, liquid fat 5~15%, Borojo 0.1~3.0%, preservative 0.5~3.0%, Yi Jiyu
The water of amount.
2. a kind of precious Rogor nano liposomes as described in claim 1, it is characterised in that: by the group of following mass percentage
It is grouped as: octyl dodecanol 2%, glycerol 10%, hydrolecithin 5.0%, EDTA-2Na 0.1%, sterols 10%, spermaceti
Alcohol polyethers 6%, liquid fat 15%, Borojo 3.0%, the water of preservative 3.0% and surplus.
3. a kind of precious Rogor nano liposomes as described in claim 1, it is characterised in that: by the group of following mass percentage
It is grouped as: octyl dodecanol 5.0%, glycerol 5%, hydrolecithin 0.5%, EDTA-2Na 0.01%, sterols 4%, spermaceti
Alcohol polyethers 2%, liquid fat 5%, Borojo 0.1%, the water of preservative 0.5% and surplus.
4. a kind of precious Rogor nano liposomes as described in claim 1, it is characterised in that: by the group of following mass percentage
Be grouped as: octyl dodecanol 3%, glycerol 8%, hydrolecithin 3%, EDTA-2Na 0.05%, sterols 7%, cetanol are poly-
Ethers 4%, liquid fat 9%, Borojo 1%, the water of preservative 1% and surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910437457.1A CN110200866A (en) | 2019-05-23 | 2019-05-23 | A kind of treasured Rogor nano liposomes and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910437457.1A CN110200866A (en) | 2019-05-23 | 2019-05-23 | A kind of treasured Rogor nano liposomes and preparation method thereof |
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| CN201910437457.1A Pending CN110200866A (en) | 2019-05-23 | 2019-05-23 | A kind of treasured Rogor nano liposomes and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050117958A (en) * | 2004-06-12 | 2005-12-15 | 에스케이케미칼주식회사 | Topical nano liposome formulation including extracted purified herbal mixture and whitening cosmetics using this formulation |
| CN103860429A (en) * | 2014-03-13 | 2014-06-18 | 广州市宜健医学技术发展有限公司 | Borojo skin-care product and natural moisturizing, anti-aging, ultraviolet-resistant, antiallergic and skin-whitening applications thereof |
| CN103948530A (en) * | 2014-05-06 | 2014-07-30 | 广州雅纯化妆品制造有限公司 | Baoleguo (Chinese character) moisturizing composition and preparation method thereof |
-
2019
- 2019-05-23 CN CN201910437457.1A patent/CN110200866A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050117958A (en) * | 2004-06-12 | 2005-12-15 | 에스케이케미칼주식회사 | Topical nano liposome formulation including extracted purified herbal mixture and whitening cosmetics using this formulation |
| CN103860429A (en) * | 2014-03-13 | 2014-06-18 | 广州市宜健医学技术发展有限公司 | Borojo skin-care product and natural moisturizing, anti-aging, ultraviolet-resistant, antiallergic and skin-whitening applications thereof |
| CN103948530A (en) * | 2014-05-06 | 2014-07-30 | 广州雅纯化妆品制造有限公司 | Baoleguo (Chinese character) moisturizing composition and preparation method thereof |
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Application publication date: 20190906 |
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