CN110199994A - A kind of disinfectant and preparation method thereof, application, feed addictive - Google Patents
A kind of disinfectant and preparation method thereof, application, feed addictive Download PDFInfo
- Publication number
- CN110199994A CN110199994A CN201910526171.0A CN201910526171A CN110199994A CN 110199994 A CN110199994 A CN 110199994A CN 201910526171 A CN201910526171 A CN 201910526171A CN 110199994 A CN110199994 A CN 110199994A
- Authority
- CN
- China
- Prior art keywords
- disinfectant
- thymol
- citric acid
- water
- acidulant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000645 desinfectant Substances 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 87
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 82
- 239000005844 Thymol Substances 0.000 claims abstract description 41
- 229960000790 thymol Drugs 0.000 claims abstract description 41
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960000935 dehydrated alcohol Drugs 0.000 claims abstract description 20
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims abstract description 10
- 239000004330 calcium propionate Substances 0.000 claims abstract description 10
- 235000010331 calcium propionate Nutrition 0.000 claims abstract description 10
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000004281 calcium formate Substances 0.000 claims abstract description 9
- 229940044172 calcium formate Drugs 0.000 claims abstract description 9
- 235000019255 calcium formate Nutrition 0.000 claims abstract description 9
- 239000000470 constituent Substances 0.000 claims abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 18
- 244000144977 poultry Species 0.000 claims description 8
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- 230000008901 benefit Effects 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 4
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 3
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 3
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 3
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 3
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 3
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 3
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 3
- 240000000171 Crataegus monogyna Species 0.000 claims description 3
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 3
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 3
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000003651 drinking water Substances 0.000 claims description 3
- 235000020188 drinking water Nutrition 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
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- 238000009472 formulation Methods 0.000 abstract description 2
- 230000002147 killing effect Effects 0.000 abstract description 2
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 10
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 9
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- 238000000034 method Methods 0.000 description 4
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 244000063299 Bacillus subtilis Species 0.000 description 2
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 244000131522 Citrus pyriformis Species 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
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- 239000003921 oil Substances 0.000 description 2
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- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
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- 230000002265 prevention Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
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- 241000193738 Bacillus anthracis Species 0.000 description 1
- 108010002217 Calcifying Nanoparticles Proteins 0.000 description 1
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 240000004670 Glycyrrhiza echinata Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
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- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
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- 241000607142 Salmonella Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 240000002657 Thymus vulgaris Species 0.000 description 1
- 235000007303 Thymus vulgaris Nutrition 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003373 anti-fouling effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
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- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
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- 230000003834 intracellular effect Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
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- 239000002609 medium Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
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- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
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- A23L3/349—Organic compounds containing oxygen with singly-bound oxygen
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- A—HUMAN NECESSITIES
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- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
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- A23L3/3481—Organic compounds containing oxygen
- A23L3/3499—Organic compounds containing oxygen with doubly-bound oxygen
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
- A23L3/3517—Carboxylic acid esters
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The present invention relates to a kind of disinfectant and preparation method thereof, application, feed addictive, including active constituent, acidulant and water;Active constituent includes: Thymol 0.001%~0.06%, lauric monoglyceride 0.01%~0.1%, dehydrated alcohol 0.5~5% in terms of the mass percent for accounting for the disinfectant;Wherein, the acidulant is selected from terms of the mass percent for accounting for the disinfectant: citric acid 0.01~0.4%, calcium formate 1%~1.5%, at least one of calcium propionate 1%~1.5%.Sanitizer formulations of the invention are fairly simple, it is environmentally protective nontoxic, irritation is small, Small side effects, pass through the microemulsion system that the formation such as hydrophobic Thymol and lauric monoglyceride, dehydrated alcohol are stable, sterilizing rate and the rate of killing the virus can achieve 99.99% or more, belong to the compound disinfecting agent prescription of nontoxic, efficient, quick-acting, wide spectrum, stabilization, safety.
Description
Technical field
The present invention relates to disinfectant preparation fields to raise in particular to a kind of disinfectant and preparation method thereof, application
Feed additives.
Background technique
Disinfection is the emphasis that all trades and professions need to pay close attention to, because only that carrying out disinfection can be only achieved prevention disease
Disease, the purpose for keeping health, and then reach the route of transmission of dissection pathogen, prevent and control the generation infected.
In various fields, the disinfection in especially livestock and poultry field is particularly important.From African swine fever epidemic situation in 2018 in
After state's outburst, Live Pig Development receives baptism.In livestock and poultry breeding industry, its route of transmission of many pathogenic bacteria mainly with sky
Gas and pathogen are infected by contact, so the disinfection for carrying out cultivation links is the important link of bio-safety prevention and control.
Caustic soda has serious corrosivity and irritation, formaldehyde, bleaching powder, sodium carbonate in the disinfectant of mainstream on the market at present
There are certain corrosivity and irritation, there are the harm of secondary pollution.
In view of this, the present invention is specifically proposed.
Summary of the invention
The first object of the present invention is to provide a kind of formula of disinfectant, and the formula is fairly simple, environmentally protective nontoxic,
Irritation is small, Small side effects, steady by will be formed after hydrophobic Thymol and lauric monoglyceride, dehydrated alcohol mixture
Fixed microemulsion system, the addition of acidulant can further promote the stability and bactericidal effect of disinfectant, sterilizing rate and kill
Viral rate can achieve 99.99% or more, belong to the compound disinfecting agent prescription of nontoxic, efficient, quick-acting, wide spectrum, stabilization, safety.
The second object of the present invention is to provide the preparation method of above-mentioned disinfectant, which has and can completely retain
The advantages of effective ingredient of each component, and have many advantages, such as that method is simple, easily operated, operating condition is mild.
The third object of the present invention is to provide the application comprising above-mentioned disinfectant, which can be widely used in respectively
In terms of the disinfection in a field, especially there is extensive adaptability in terms of livestock and poultry disinfection field, therefore should be widely promoted and answered
With.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
The present invention provides a kind of disinfectants, including active constituent, acidulant and water;
The active constituent includes: Thymol 0.001%~0.06% in terms of the mass percent for accounting for the disinfectant,
Lauric monoglyceride 0.01%~0.1%, dehydrated alcohol 0.5~5%;
Wherein, the acidulant is selected from terms of the mass percent for accounting for the disinfectant: citric acid 0.01~0.4%, first
Sour calcium 1%~1.5%, at least one of calcium propionate 1%~1.5%.
Wherein, Thymol belongs to thyme essential oil extract, is a kind of lyophobic dust, has green, safety height
The features such as effect, is that FDA ratifies the natural additive for foodstuff and drug ingedient that use, can partially or completely substitute traditional chemical anti-corrosion
Agent.
In addition to this, Thymol is also a kind of natural, has very strong Scavenging ability.But its water
Dissolubility problem limits always it and is widely used, and not only use cost is high, and undissolved part also will affect the bioactivity of product.
Due to most microorganisms only in water phase could growth and breeding, and all enzymatic biochemical reactions related with vital movement
It is carried out in water phase with Antioxidation reaction, therefore, only Thymol is sufficiently dissolved or is dispersed in water phase, Cai Nengzuo
For object, its biological effect is played.
Lauric monoglyceride is both the antibacterial agent of excellent emulsifier and safe and efficient wide spectrum, with to togavirus
The duplication and propagation of (AIDS, blue otopathy, swine fever, African swine fever virus) have inhibiting effect, and disadvantage is not soluble in water.
Dehydrated alcohol can be made into 70%-75% ethyl alcohol as disinfectant, but its irritation is strong, and inflammable volatile.Ethyl alcohol
Cosurfactant be can be used as by reducing oil water interfacial tension, improve the spontaneous curvature in interface, and reduce interface rigidity and come
Promote the formation of microemulsion.
Citric acid is dissolved in water and generates H+And free radical, the H of generation+It can change intracellular pH value, to change microorganism
Living environment, be widely used in the neck such as seasoning and anti-corrosion, the disinfection of accurate Medical Devices and environmental protection be antifouling of food service industry
Domain, but it is acid too strong, has strong impulse to gastrointestinal tract.
Calcium formate, calcium propionate are as a kind of feed addictive, and can dissociate micro formic acid out in animal body, make gastrointestinal tract pH
Value reduces, and there is buffer function to make gastrointestinal tract pH stable, to inhibit the breeding of harmful bacteria, promotes beneficial microbe
Growth.
In the solution of the present invention, acidulant has only selected any one of citric acid, calcium formate, calcium propionate in these three
Or more, because not all acidulant all has the effect of that hydrotropy helps disinfection, it is the need for the progress of purpose
Selection.
The present invention, and cannot biodegrade in order to overcome the severe corrosive of environment disinfectant, irritation on existing market
Have the defects that secondary hazards, fill up cannot take orally, impregnate, the blank of livestock and poultry surface spray disinfectant.Screening a large amount of formulas
Afterwards, Thymol, lauric acid monoglyceride, organic acid, the edible component of ethyl alcohol is selected to construct stable microemulsion system.
The present invention, which carries out compound assistant to above each folk prescription, to be made, and it is water-soluble to solve Thymol using the technology of microemulsified
Property, Surfactant and oil mutually with cosurfactant proportion selected, determine best multicomponent system.By to system
Disinfection Effect is evaluated, and is found the Disinfection Effect of compound better than folk prescription and is substantially reduced disinfection cost, can safely and effectively use
In poultry environment and disinfection of drinking water, and the disinfectant is non-stimulated, environmentally protective, and disinfection effect is excellent.
In addition, why selected this surfactant of lauric monoglyceride, because we have found that anion and
Cationic surfactant is difficult to form microemulsion under high dilution, and nonionic surface active agent contributes to form high concentration
The formation of surfactant microemulsion system, but common non-ionic Tweens, to nanobacteria innocuous, Tween 80 is even to knot
The irritating growth of core mycobacterium, thus screen lauric monoglyceride not only solubilising again can using inhibit virus and remove from office orchid
The performance of family name's positive bacteria.
In dosage, by being formulated in the ratio range of reasonable and suitable, the Disinfection Effect of disinfectant can be significantly improved,
The concentration of ethyl alcohol is reduced between 0.5%~5% in system, substantially reduces its security risk.
Preferably as further enforceable scheme, the acidulant is in terms of the mass percent for accounting for the disinfectant
Be selected from: citric acid 0.01~0.4%, calcium formate 1%~1.5% and calcium propionate 1%~1.5%, triplicity using effect compared with
It is good, in this way while playing itself bacteriostasis, the pH value of system is reduced, it, can when dropping to 5 or less by research discovery pH
Greatly enhance the bacteriostasis of Thymol.
Preferably as further enforceable scheme, the acidulant is citric acid 0.01~0.4%.Citric acid sheet
Body relative cost is low, can guarantee in the case where at low cost in this way, Disinfection Effect is optimal.
Preferably as further enforceable scheme, by percentage to the quality, Thymol 0.006%~0.03%,
Lauric monoglyceride 0.02%~0.06%, citric acid 0.04%~0.2%, dehydrated alcohol 1%~4%, surplus are water.
Preferably as more optimal solution, by percentage to the quality, Thymol 0.06%, lauric monoglyceride
0.05%, citric acid 0.4%, dehydrated alcohol 0.5%, surplus is water.
Preferably, more optimal solution can also be matched according to formula as below, by percentage to the quality, Thymol
0.06%, lauric monoglyceride 0.1%, citric acid 0.4%, dehydrated alcohol 0.5%, surplus is water.
In addition to this, the content of Thymol can also for 0.002%, 0.005%, 0.01%, 0.02%, 0.04%,
0.05% etc..
The content of lauric monoglyceride can also be 0.03%, 0.04%, 0.05%, 0.07%, 0.08%, 0.09%
Deng.
The content of dehydrated alcohol can also be 1.5%, 2%, 2.5%, 3%, 3.5% etc..
The present invention additionally provides the preparation method of above-mentioned disinfectant, includes the following steps: in addition to providing the formula of disinfectant
(A) it dissolves Thymol and absolute ethyl alcohol and stirring to obtain the first mixed liquid;
(B) the absolute ethyl alcohol and stirring solution of lauric monoglyceride and surplus is obtained into the second mixed liquid;
(C) third will be formed after acidulant and a small amount of water mixed dissolution mix liquid;
Wherein step (A), (B), (C) are without sequencing;
(D) the described first mixed liquid, the second mixed liquid are mixed liquid with the third and is uniformly mixed, add water to final volume.
Preparation method of the invention is easy to operate, and operating method is easy to implement, and by controlling order of addition, can be improved mixed
The uniformity of disinfectant after conjunction.
Preferably as further enforceable scheme, in the step (D), the mixing passes through high in homogenizer
Speed stirring carries out;
Preferably, liquid is mixed with the third again after the second mixed liquid is mixed with the first mixed liquid to mix.
Add the present invention provides the feed comprising above-mentioned disinfectant and comprising the obtained disinfectant of above-mentioned preparation method
Add agent.
It preferably, also include hawthorn, Radix Glycyrrhizae, lactose in the feed addictive, the addition of these substances can promote to raise
The appetite of fowl.
Disinfectant of the invention can be widely used in livestock and poultry disinfection, drinking water disinfection, environment disinfected etc., as long as having
The place of disinfection demand is applicable in.
Compared with prior art, the invention has the benefit that
(1) disinfectant of the invention is steady by the formation such as hydrophobic Thymol and lauric monoglyceride, dehydrated alcohol
Fixed microemulsion system, sterilizing rate and the rate of killing the virus can achieve 99.99% or more;
(2) disinfectant of the invention is the compound disinfecting agent prescription of nontoxic, efficient, quick-acting, wide spectrum, stabilization, safety;
(3) disinfectant is widely used, and especially has extensive adaptability in terms of livestock and poultry disinfection field.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person, carries out according to conventional conditions or manufacturer's recommended conditions, and reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
The solution of the present invention is illustrated below by specific embodiment:
Embodiment 1
The formula (concentration by mass percentage) of disinfectant is formed with following component:
Thymol 0.03%;
Lauric monoglyceride 0.05%;
Calcium formate 1.5%;
Dehydrated alcohol 5%;
Water surplus.
The preparation method of disinfectant is in accordance with the following steps:
1, weigh each component, the anhydrous second of a small amount of cosolvent first Thymol being dissolved in the first container by formula ratio
In alcohol, high-speed stirred is to being completely dissolved;
2, it takes second container to weigh lauric monoglyceride, dehydrated alcohol hydrotropy is added;
3, it takes third container to weigh calcium formate, a small amount of water dissolution is added, high-speed stirred is uniform, and then the above solution exists
The stirring of homogenizer high speed is lower plus water is supplemented to final volume.
Embodiment 2
Concrete operation step and above-described embodiment 1 are consistent, and only it is formulated (concentration by mass percentage) according to the following group
It is grouped as: Thymol 0.001%, lauric monoglyceride 0.01%, calcium propionate 1.5%, dehydrated alcohol 1%, water surplus.
Embodiment 3
Concrete operation step and above-described embodiment 1 are consistent, and only it is formulated (concentration by mass percentage) according to the following group
It is grouped as: Thymol 0.006%, lauric monoglyceride 0.02%, calcium propionate 1%, calcium formate 1%, citric acid 0.01%,
Dehydrated alcohol 4%, water surplus.
Embodiment 4
The formula (concentration by mass percentage) of disinfectant is formed with following component:
Thymol 0.06%;
Lauric monoglyceride 0.1%;
Citric acid 0.4%;
Dehydrated alcohol 0.5%;
Water surplus.
The preparation method of disinfectant is in accordance with the following steps:
1, weigh each component, the anhydrous second of a small amount of cosolvent first Thymol being dissolved in the first container by formula ratio
In alcohol, high-speed stirred is to being completely dissolved;
2, it takes second container to weigh lauric monoglyceride, dehydrated alcohol hydrotropy is added;
3, it takes third container to weigh citric acid, a small amount of water dissolution is added, high-speed stirred is uniform, will be in second container
Solution pours into the first container, reinforces stirring to substantially uniformity and surveys pH value, then considers and citric acid solution adjustment pH value 3- is added
5, it is filling.
Comparative example 1
Concrete operation step and above-described embodiment 4 are consistent, and only Thymol content is 0.1% in its formula.
Comparative example 2
Concrete operation step and above-described embodiment 4 are consistent, and only Thymol content is 0.0006% in its formula.
Application examples
Thymol 0.015% (0.15kg), lauric monoglyceride 0.015% (0.15kg), first are added in 1 ton of feed
Sour calcium 0.015% (0.15kg), calcium propionate 0.015% (0.15kg), citric acid 0.015% (0.15kg), lactose 0.015%
(0.15kg), hawthorn powder 0.01% (0.1kg), licorice powder 0.01% (0.1kg), each component mix in proportion.
The Detection of Stability of 1 disinfectant of experimental example
The appearance for the disinfectant that above-described embodiment and comparative example are prepared and stability are evaluated, specifically
The method for measuring stability are as follows: it is hard that 300ml standard is added in the compound disinfectant that above-described embodiment and comparative example are prepared
It in water, shakes up, 30min is stood at 30 DEG C, concrete outcome see the table below shown in 1.
1 testing result of table
The bacteriostatic test of 2 disinfectant of experimental example
Measure embodiment 2 disinfectant and comparative example 1-2, single component to common causative (Escherichia coli,
Staphylococcus aureus) and the suppression of common probiotics (bacillus subtilis) kill effect.
Method: taking 1m to cultivate respectively in disinfectant and single component with nutrient medium 1ml, and inoculation is by rejuvenation respectively
Escherichia coli, staphylococcus aureus, bacillus subtilis are inoculated in nutrient agar panel and cultivate 12- at 37 DEG C
24 hours, observe result.Positive control plate has bacterium growth, negative control plates asepsis growth.
The evaluation of 2 fungistatic effect of table
It is antibacterial under low concentration as can be seen that one pack system Thymol and one pack system lauric acid are not soluble in water from above-mentioned table 2
Power is very weak, and Glycerol Monolaurate is insensitive to Escherichia coli.Low concentration citric acid and the antibacterial power of ethyl alcohol are unobvious.
Each folk prescription is made after microemulsion system plays synergistic effect well, enhances the bacteriostasis of system in acid condition.
The formulation optimization of 3 disinfectant of experimental example
1, Thymol Mlc
Thymol has stronger inhibiting effect to bacterium, mould, yeast, wherein the inhibiting effect to bacterium is most strong.
Thymol is to the minimal inhibitory concentration of bacterium between 10-160 μ g/mL.
2, Glycerol Monolaurate Mlc
Glycerol Monolaurate to Escherichia coli, bright Buddhist nun's soda salmonella, pseudomonas aeruginosa, clostridium perfringen, proteus,
The unknown sense of Shigella sonnei, Friedlander's bacillus, to staphylococcus aureus, streptococcus, Listeria monocytogenes, anthrax bar
The minimum inhibitory concentration of 39 kinds of common bacterias such as bacterium, bacillus aerogenes capsulatus, Candida albicans is between 1-500 μ g/mL.
3, citric acid Mlc is between 0.625-20mg/mL.
4, Thymol, Glycerol Monolaurate, citric acid Three factors-levels orthogonal experiment are taken.
Specifically based on embodiment 4, other operating procedures and embodiment 4 are consistent, only convert Thymol, the moon
The content of three kinds of cinnamic acid monoglyceride, citric acid substances, is specifically shown in the following table 3-4.
3 compound disinfectant screening test factor level table of table
The antibacterial result of table 4
Tested number | Citric acid (W/V) | Lauric monoglyceride rouge (W/V) | Thymol (W/V) | Concentration (cfu/ml) after antibacterial |
1 | 1 | 1 | 1 | 0 |
2 | 1 | 2 | 2 | 102 |
3 | 1 | 3 | 3 | 104 |
4 | 2 | 1 | 2 | 103 |
5 | 2 | 2 | 3 | 104 |
6 | 2 | 3 | 1 | 10 |
7 | 3 | 1 | 3 | 106 |
8 | 3 | 2 | 1 | 0 |
9 | 3 | 3 | 2 | 107 |
By for statistical analysis to the data in above-mentioned table, from mean value feedback as a result, citric acid water should be selected
Flat 1, Glycerol Monolaurate level 2, Thymol level 1.
The result that can be seen that three from the result of variance is not significant (Pvalue value is both greater than 0.05), but lemon
Sour Pvalue value is minimum, so the selection of citric acid is most important, Glycerol Monolaurate and Thymol are relatively.Ours
There is no citric acid level 1 in experimental design, Glycerol Monolaurate level 2 in the case where Thymol level 1, can choose lemon
Lemon sour water flat 1, Glycerol Monolaurate level 2, Thymol level 2 or citric acid level 1, Glycerol Monolaurate level 1, hundred
In fragrant phenol level 1.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention
Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of disinfectant, which is characterized in that including active constituent, acidulant and water;
The active constituent includes: Thymol 0.001%~0.06%, laurel in terms of the mass percent for accounting for the disinfectant
Sour monoglyceride 0.01%~0.1%, dehydrated alcohol 0.5~5%;
Wherein, the acidulant is selected from terms of the mass percent for accounting for the disinfectant: citric acid 0.01~0.4%, calcium formate
1%~1.5%, at least one of calcium propionate 1%~1.5%.
2. disinfectant according to claim 1, which is characterized in that the acidulant is to account for the quality percentage of the disinfectant
Than being calculated as citric acid 0.01~0.4%, calcium formate 1%~1.5% and calcium propionate 1%~1.5%.
3. disinfectant according to claim 1, which is characterized in that the acidulant is citric acid 0.01~0.4%.
4. disinfectant according to claim 1-3, which is characterized in that by percentage to the quality, Thymol
0.006%~0.03%, lauric monoglyceride 0.02%~0.06%, citric acid 0.04%~0.2%, dehydrated alcohol 1%
~4%, surplus is water.
5. disinfectant according to claim 1-3, which is characterized in that by percentage to the quality, Thymol
0.06%, lauric monoglyceride 0.05%, citric acid 0.4%, dehydrated alcohol 0.5%, surplus is water.
6. disinfectant according to claim 1-3, which is characterized in that by percentage to the quality, Thymol
0.06%, lauric monoglyceride 0.1%, citric acid 0.4%, dehydrated alcohol 0.5%, surplus is water.
7. the preparation method of disinfectant according to claim 1-6, which comprises the steps of:
(A) it dissolves Thymol and absolute ethyl alcohol and stirring to obtain the first mixed liquid;
(B) the absolute ethyl alcohol and stirring solution of lauric monoglyceride and surplus is obtained into the second mixed liquid;
(C) third will be formed after acidulant and a small amount of water mixed dissolution mix liquid;
Wherein step (A), (B), (C) are without sequencing;
(D) the described first mixed liquid, the second mixed liquid are mixed liquid with the third and is uniformly mixed, add water to final volume.
8. preparation method according to claim 7, which is characterized in that in the step (D), the mixing is by homogeneous
The stirring of machine high speed carries out;
Preferably, liquid is mixed with the third again after the second mixed liquid is mixed with the first mixed liquid to mix.
9. a kind of feed addictive, which is characterized in that include disinfectant described in any one of claims 1-6 or comprising power
Benefit requires the obtained disinfectant of the preparation method of any one of 7-8;
It preferably, also include hawthorn, Radix Glycyrrhizae, lactose in the feed addictive.
10. application of the disinfectant described in any one of claims 1-6 in terms of livestock and poultry disinfection, drinking water disinfection, environment disinfected.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111213786A (en) * | 2020-01-14 | 2020-06-02 | 山东信得科技股份有限公司 | Water quality acidifying agent for preventing and controlling African swine fever and preparation method and application thereof |
CN115136963A (en) * | 2022-07-13 | 2022-10-04 | 武汉天楚生物科技有限公司 | Acidic dry powder disinfectant and preparation method and application thereof |
CN115843953A (en) * | 2022-12-28 | 2023-03-28 | 珠海市自然之旅生物技术有限公司 | Antibacterial composition and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102132938B (en) * | 2011-03-22 | 2013-05-01 | 宁波大学 | Citric acid-lauric acid monoglyceryl ester microemulsion and preparation method thereof |
CN103583922A (en) * | 2013-11-25 | 2014-02-19 | 广州美瑞泰科生物工程技术有限公司 | Poultry used disease-resistant growth promotion green feed additive and preparing method thereof |
CN105815572A (en) * | 2016-03-21 | 2016-08-03 | 浙江日出生物科技有限公司 | Antimicrobial compound acidifier |
-
2019
- 2019-06-18 CN CN201910526171.0A patent/CN110199994A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102132938B (en) * | 2011-03-22 | 2013-05-01 | 宁波大学 | Citric acid-lauric acid monoglyceryl ester microemulsion and preparation method thereof |
CN103583922A (en) * | 2013-11-25 | 2014-02-19 | 广州美瑞泰科生物工程技术有限公司 | Poultry used disease-resistant growth promotion green feed additive and preparing method thereof |
CN105815572A (en) * | 2016-03-21 | 2016-08-03 | 浙江日出生物科技有限公司 | Antimicrobial compound acidifier |
Non-Patent Citations (1)
Title |
---|
王凤英: "《科学养猪技术问答》", 30 November 2010 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111213786A (en) * | 2020-01-14 | 2020-06-02 | 山东信得科技股份有限公司 | Water quality acidifying agent for preventing and controlling African swine fever and preparation method and application thereof |
CN111213786B (en) * | 2020-01-14 | 2023-06-16 | 山东信得科技股份有限公司 | Water quality acidulant for preventing and controlling African swine fever as well as preparation method and application thereof |
CN115136963A (en) * | 2022-07-13 | 2022-10-04 | 武汉天楚生物科技有限公司 | Acidic dry powder disinfectant and preparation method and application thereof |
CN115843953A (en) * | 2022-12-28 | 2023-03-28 | 珠海市自然之旅生物技术有限公司 | Antibacterial composition and preparation method and application thereof |
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