CN110191640A - Aqueous hydrogen peroxide for sterilization solution - Google Patents
Aqueous hydrogen peroxide for sterilization solution Download PDFInfo
- Publication number
- CN110191640A CN110191640A CN201780084068.4A CN201780084068A CN110191640A CN 110191640 A CN110191640 A CN 110191640A CN 201780084068 A CN201780084068 A CN 201780084068A CN 110191640 A CN110191640 A CN 110191640A
- Authority
- CN
- China
- Prior art keywords
- hydrogen peroxide
- aqueous solution
- disinfection
- mist
- steam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 126
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 41
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 23
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000003595 mist Substances 0.000 claims abstract description 29
- 239000007864 aqueous solution Substances 0.000 claims abstract description 28
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 26
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 26
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims abstract description 25
- 239000004411 aluminium Substances 0.000 claims abstract description 23
- 235000011007 phosphoric acid Nutrition 0.000 claims abstract description 20
- 238000005406 washing Methods 0.000 claims abstract description 17
- 150000003009 phosphonic acids Chemical class 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 36
- 239000007789 gas Substances 0.000 claims description 21
- 238000001704 evaporation Methods 0.000 claims description 11
- 230000008020 evaporation Effects 0.000 claims description 11
- 235000013305 food Nutrition 0.000 claims description 11
- 238000012360 testing method Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000003570 air Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 abstract description 11
- 239000003381 stabilizer Substances 0.000 description 17
- 239000000654 additive Substances 0.000 description 14
- 230000000996 additive effect Effects 0.000 description 14
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 12
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 11
- 239000002253 acid Substances 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- -1 hydrophosphates Chemical compound 0.000 description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 description 6
- 235000011152 sodium sulphate Nutrition 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000012371 Aseptic Filling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000004088 simulation Methods 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 238000010025 steaming Methods 0.000 description 3
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229940037003 alum Drugs 0.000 description 2
- 159000000013 aluminium salts Chemical class 0.000 description 2
- 229910000329 aluminium sulfate Inorganic materials 0.000 description 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 2
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 235000019837 monoammonium phosphate Nutrition 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 2
- 235000019798 tripotassium phosphate Nutrition 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical group [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- VPTUPAVOBUEXMZ-UHFFFAOYSA-N (1-hydroxy-2-phosphonoethyl)phosphonic acid Chemical compound OP(=O)(O)C(O)CP(O)(O)=O VPTUPAVOBUEXMZ-UHFFFAOYSA-N 0.000 description 1
- BNGXYYYYKUGPPF-UHFFFAOYSA-M (3-methylphenyl)methyl-triphenylphosphanium;chloride Chemical compound [Cl-].CC1=CC=CC(C[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 BNGXYYYYKUGPPF-UHFFFAOYSA-M 0.000 description 1
- MGRVRXRGTBOSHW-UHFFFAOYSA-N (aminomethyl)phosphonic acid Chemical compound NCP(O)(O)=O MGRVRXRGTBOSHW-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- JKTORXLUQLQJCM-UHFFFAOYSA-N 4-phosphonobutylphosphonic acid Chemical compound OP(O)(=O)CCCCP(O)(O)=O JKTORXLUQLQJCM-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229940120146 EDTMP Drugs 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 1
- KIDJHPQACZGFTI-UHFFFAOYSA-N [6-[bis(phosphonomethyl)amino]hexyl-(phosphonomethyl)amino]methylphosphonic acid Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCCCCCN(CP(O)(O)=O)CP(O)(O)=O KIDJHPQACZGFTI-UHFFFAOYSA-N 0.000 description 1
- ZXRRHFSTAFVGOC-UHFFFAOYSA-N [AlH3].[K] Chemical compound [AlH3].[K] ZXRRHFSTAFVGOC-UHFFFAOYSA-N 0.000 description 1
- YDONNITUKPKTIG-UHFFFAOYSA-N [Nitrilotris(methylene)]trisphosphonic acid Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CP(O)(O)=O YDONNITUKPKTIG-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- QOSATHPSBFQAML-UHFFFAOYSA-N hydrogen peroxide;hydrate Chemical compound O.OO QOSATHPSBFQAML-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 235000001055 magnesium Nutrition 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 235000014786 phosphorus Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940048084 pyrophosphate Drugs 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
- A01N25/06—Aerosols
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P3/00—Fungicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
- A61L9/02—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air by heating or combustion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
- B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2101/00—Chemical composition of materials used in disinfecting, sterilising or deodorising
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Abstract
The present invention provides a kind of aqueous hydrogen peroxide solution for being easy removing residue, the sterilization used in the form of mist or steam less and then using washing to the attachment of the residue of spray nozzle.Above-mentioned technical problem can use following aqueous solution according to one embodiment and solve, the aqueous solution is the aqueous hydrogen peroxide solution of the sterilization used in the form of mist or steam, the aqueous solution contains hydrogen peroxide, 2ppm or more 8ppm orthophosphoric acid below or phosphonic acids, 10ppb or more 500ppb aluminium below and sulfate ion, and the content of above-mentioned sulfate ion is 10 times or more 20 times or less relative to the content of above-mentioned aluminium by quality ratio.
Description
Technical field
The present invention relates to a kind of aqueous hydrogen peroxide solutions of sterilization used in the form of mist or steam.The present invention also relates to
And a kind of method for disinfection of object, the method for disinfection of the object are characterized in that, make aqueous hydrogen peroxide solution with mist or steaming
The form of gas is contacted with object.
Background technique
Aqueous solution containing hydrogen peroxide is used as various fungicide.In addition, make fungicide in the form of mist or steam with it is right
Before the technology sterilized as object is contacted to object is suitable for the sterilization and beverage filling of the toilet of used in electronic industry
The sterilization etc. of PET bottle.Especially in recent years, popularizing with PET bottle, it is water-soluble for hydrogen peroxide used in aseptic filling
Liquid, required performance improve.I.e., it is desirable that when making hydrogen peroxide and water evaporation under residue few aqueous solution or high temperature or
The high aqueous solution of stability in metal storage container.
For aseptic filling using in the case where the aqueous solution containing hydrogen peroxide, it is known that utilize evaporator by peroxidating
Aqueous solution of hydrogen is heated to boiling point or more and is vaporized, is sprayed the gas of hydrogen peroxide together with air to kill to container
The method (referring to patent document 1) of bacterium.However, in the method, existing and adding the stabilizer in aqueous hydrogen peroxide solution
A part be attached to spray nozzle, evaporator and block with pipe portion etc., hinder aseptic filling device stable operation the problem of.
In addition, being stored in canisters such as stainless steels, there are stabilitys if the stablizing effect of stabilizer is insufficient
The problem of being unable to maintain that.
So far, the method as the stability for solving above-mentioned blockage problem or hydrogen peroxide, propose reduction to
The additive amount of the stabilizer of aqueous hydrogen peroxide solution addition.For example, report has using aminomethy-lenephosphonic acids in patent document 2
It reduces drying residue and ensures the method for the stability of hydrogen peroxide.
Existing technical literature
Patent document
Patent document 1: Japanese Unexamined Patent Publication 11-47242 bulletin
Patent document 2: Japanese Unexamined Patent Publication 2013-028643 bulletin
Summary of the invention
Technical problems to be solved by the inivention
As described above, having proposed the method for solving blockage problem or stability at present.However, pair as blockage problem
Plan also cannot be completely eliminated spray nozzle, attached on evaporator even if reducing the additive amount of the stabilizer in aqueous hydrogen peroxide solution
The residual of object, and since the attachment of phosphonic acids system is slightly solubility, thus exist blocking with pipe portion, resistance cannot be fully solved
The possibility for the problem of hindering the stable operation of aseptic filling device.
In addition, the nearest research of inventor according to the present invention is learnt, due in aqueous hydrogen peroxide solution as stablizing
Phosphoric acid or chelating agent added by agent dissolve out micro metal, the stability decline of hydrogen peroxide from made of metal storage tank.Largely
The interruption of service that when using stabilizer, can be avoided the decline of stability, but easily cause above-mentioned spray nozzle blocking etc., because
This need to further improve.
The object of the present invention is to provide a kind of to adhere to less to the residue of spray nozzle and then utilize the easy removing of washing residual
Slag, the sterilization used in the form of mist or steam aqueous hydrogen peroxide solution.
For solving the technical solution of technical problem
The present inventor studies intensively above-mentioned technical problem repeatedly, as a result, it has been found that, contain hydrogen peroxide, orthophosphoric acid
Or the ratio between content of phosphonic acids, aluminium and sulfate ion and aluminium and sulfate ion can be improved peroxide in the aqueous solution of particular range
Change the stability of hydrogen, reduces the attachment that attachment remains on the stabilizer in aqueous hydrogen peroxide solution of spray nozzle and evaporator
Object, and residue can be easily removed using washing, so that reach the present invention.
That is, the present invention is as described below.
[1] a kind of aqueous solution, is the aqueous hydrogen peroxide solution of the sterilization used in the form of mist or steam, this is water-soluble
Liquid contains:
Hydrogen peroxide；
2ppm or more 8ppm orthophosphoric acid below or phosphonic acids；
10ppb or more 500ppb aluminium below；With
Sulfate ion,
The content of above-mentioned sulfate ion is 10 times or more 20 times or less relative to the content of above-mentioned aluminium by quality ratio.
[2] aqueous solution as described in [1], wherein the concentration of above-mentioned hydrogen peroxide be 20 mass % or more, 45 mass % with
Under.
[3] aqueous solution as described in [1] or [2], wherein evaporation residue amount is 10ppm or less.
[4] aqueous solution as described in any one of [1]~[3], wherein the washing removal rate in evaporator adhiesion test is
40% or more.
[5] aqueous solution as described in any one of [1]~[4], contains:
2ppm or more 5ppm orthophosphoric acid below；With
50ppb or more 250ppb aluminium below.
[6] aqueous solution as described in any one of [1]~[5] is used for the sterilization of container package material, utensil sterilization or empty
Between sterilize.
[7] a kind of method for disinfection of object, which is characterized in that make aqueous solution described in any one of [1]~[6] with mist
Or the form of steam is contacted with object.
[8] method for disinfection as described in [7], wherein the temperature of above-mentioned mist or steam is 30 DEG C~250 DEG C.
[9] method for disinfection as described in [7], wherein by above-mentioned mist or steam and gas mixing, gas shape fluid is formed,
And contact the gas shape fluid with object.
[10] method for disinfection as described in [9], wherein above-mentioned gas be in air, nitrogen, oxygen and ozone extremely
It is a kind few.
[11] method for disinfection as described in any one of [7]~[10], wherein above-mentioned object is packing container, food
Machinery, PET bottle, PET bottle preform, laboratory apparatus, medical instrument, sanitary apparatus, kitchen tools or food.
[12] method for disinfection as described in any one of [7]~[10], wherein above-mentioned object is space.
[13] method for disinfection as described in [12], wherein above-mentioned space is automobile, the toilet of used in electronic industry, inhabitation
Space, Medical space, kitchen, culinary art place, vehicle or aircraft.
Invention effect
Using the present invention, the stability of hydrogen peroxide be can be improved, and can be reduced attachment and be remained on spray nozzle and evaporator
The stabilizer in aqueous hydrogen peroxide solution attachment, and can using washing easily remove residue.
Detailed description of the invention
Fig. 1 is the figure of the mass ratio for indicating sulfate ion content and aluminium content and the relationship of washing residue.
Fig. 2 is the figure for indicating the relationship of stabilizer total amount and stability.
Fig. 3 is the figure for indicating the relationship of aluminium content and stability.
Specific embodiment
Hereinafter, the present invention is described in detail.
1. the aqueous hydrogen peroxide solution of the sterilization used in the form of mist or steam
The aqueous hydrogen peroxide solution of the sterilization used in the form of mist or steam of the invention (in the present specification, has
When be also referred to as " aqueous hydrogen peroxide solution of the invention ") containing hydrogen peroxide, orthophosphoric acid or phosphonic acids, aluminium and sulfate ion.Separately
Outside, aqueous hydrogen peroxide solution of the invention can also contain other acid and/or salt is used as making to be attached to spray nozzle and steaming
The additive that the washing of the evaporation residue of hair device etc. becomes easy.
The concentration of hydrogen peroxide in aquae hydrogenii dioxidi of the invention be 20 mass % or more, preferably 25 mass % with
On.Concentration is higher, and bactericidal effect is also higher, peroxidating when considering safety when operation, in aquae hydrogenii dioxidi of the invention
The concentration of hydrogen is preferably 45 mass % or less.Preferred concentration range is 25 mass % or more, 40 mass % or less.
Aqueous hydrogen peroxide solution of the invention contains orthophosphoric acid (chemical formula H3PO4, also referred to as " phosphoric acid ") or phosphonic acids,
Content is calculated as 2ppm or more 8ppm or less with quality criteria.The lower limit value of content is preferably 3ppm, and upper limit value is preferably 6ppm, more
Preferably 5ppm.It is in the numberical range by the content of orthophosphoric acid or phosphonic acids, the stabilisation effect of hydrogen peroxide can be obtained
Fruit, the amount for being attached to the evaporation residue of evaporator and nozzle are suppressed.Ortho-phosphoric content can use well known method and carry out
Measurement, such as can use and be measured using the chromatography of ions of the DX-500 of Dionex manufacture.
Orthophosphoric acid used in the present invention is not particularly limited, and can be used by commercially available phosphorus such as rear rattan Chemical Co., Ltd.
Acid (concentration: 85%) etc..In addition, as orthophosphoric acid, it is preferable to use being designated as the substance of the specified additive of food hygiene law.
In addition, orthophosphoric acid used in the present invention can also be added in aqueous solution in the form of ortho-phosphoric salt, as such salt,
The dihydric phosphates such as potassium dihydrogen phosphate, sodium dihydrogen phosphate, ammonium dihydrogen phosphate, dipotassium hydrogen phosphate, disodium hydrogen phosphate, phosphorus can be enumerated
Phosphate such as hydrophosphates, tripotassium phosphate, the tertiary sodium phosphates such as sour hydrogen diammonium etc..
Phosphonic acids used in the present invention is not particularly limited, preferably organic phospho acid.It, can be with as such organic phospho acid
Enumerate aminomethylphosphonic acid, hydroxy ethylene diphosphonic acid, aminotrimethylenephosphonic acid, ethylenediamine tetramethylene phosphonic acid, two sub- second
Base triamine pentamethylene phosphonic acids, hexamethylene diamine tetramethylene phosphonic acid, bis hexamethylene triamine pentamethylene phosphonic acids and the third two
Amine tetramethylene phosphonic acid etc..In addition, organic phospho acid used in the present invention can also be added in aqueous solution in the form of salt.
Aqueous hydrogen peroxide solution of the invention contains 10ppb or more 500ppb aluminium below in terms of quality criteria.Aluminium contains
The lower limit value of amount is preferably 50ppb, more preferably 100ppb；Upper limit value is preferably 350ppb, more preferably 250ppb.Peroxidating
The content of aluminium in aqueous solution of hydrogen for example can use high-frequency inductive coupling plasma body (ICP) apparatus for analyzing luminosity iCAP
6000 (Thermo Fisher SCIENTIFIC manufactures) etc. are measured.When the content of aluminium is above range, it can obtain
The stabilization effect of hydrogen oxide, the amount for being attached to the evaporation residue of evaporator and spray nozzle are suppressed.
Aluminium contained by aqueous hydrogen peroxide solution of the invention can be added in aqueous solution in the form of salt, as such
The concrete example of aluminium salt is preferably listed aluminum aluminum sulfate, aluminum nitrate, aluminum sulfate, alum and oxalic acid aluminium, particularly preferably enumerates sulfuric acid
Aluminium potassium.In the present invention it is preferable to use aluminum aluminum sulfate can be hydrate as 12 hydrates.Alternatively, aluminium can also be by making
Pure aluminum or aluminum alloy is contacted with aqueous hydrogen peroxide solution and is added.In addition, as aluminium salt, particularly preferably used as food hygiene
The specified additive of method and appointed substance.
Aqueous hydrogen peroxide solution of the invention contains sulfate ion.Sulfate ion can be added to water in the form of salt
In solution, as the concrete example of such sulfate, aluminum aluminum sulfate, aluminum sulfate, alum and sodium sulphate etc. can be enumerated, but
It's not limited to that.In addition, as sulfate, it is particularly preferably appointed used as the specified additive of food hygiene law
Substance.The content of sulfate ion is preferably calculated as 100ppb~10,000ppb with quality criteria.
In aqueous hydrogen peroxide solution of the invention, the content of sulfate ion is by quality ratio relative to the content of aluminium
10 times or more, preferably 11 times or more, more preferably 12 times or more, and be 20 times or less, preferably 19 times or less, more preferable
It is 18 times or less.It is in the range by the mass ratio of the content of sulfate ion and aluminium, the stability of hydrogen peroxide can mention
Height can reduce the attachment that attachment remains on the stabilizer in aqueous hydrogen peroxide solution of spray nozzle and evaporator, and
And residue can be easily removed using washing.
Decomposition ingredient as hydrogen peroxide, it is known to heavy metal classes, as the aqueous hydrogen peroxide solution industrially manufactured
Contained decomposition ingredient, is substantially defined in Fe, Cr, Ni, Pd.It is preferable to use by Ni and Pd for aqueous hydrogen peroxide solution of the invention
Concentration be set to 0.1ppb or less and the concentration of Fe and Cr be set to 5ppb aqueous hydrogen peroxide solution below.In this way
Aqueous hydrogen peroxide solution can use well known method and obtain, can specifically enumerate and utilize distillation, ion exchange resin, absorption
Material, chelating agent, the anti-method for being impregnated with film etc. and removing metal component.
Within the scope of the effect of the invention, aqueous hydrogen peroxide solution of the invention can also be containing other public
The stabilizer of hydrogen peroxide known.As an example, by and with the desired amount of inorganic phosphate system stabilizer, also can further improve
Stability.As concrete example, pyrophosphoric acids salts such as pyrophosphoric acid hydrogen sodium, sodium pyrophosphate etc. can be enumerated, it can be according to usage
Deng requirement, contain alone or in combination.In addition, as inorganic phosphate system stabilizer, it is preferable to use finger as food hygiene law
Determine additive and appointed substance.As such inorganic phosphate system stabilizer, can enumerate tripotassium phosphate, tricalcium phosphate,
Tricresyl phosphate magnesium, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, calcium monohydrogenphosphate, calcium dihydrogen phosphate, phosphorus
Sour disodium hydrogen, sodium dihydrogen phosphate, one hydrogen magnesium of phosphoric acid and tertiary sodium phosphate etc..
Stabilizer total amount in aqueous hydrogen peroxide solution of the invention is preferably 2,500ppb~7,000ppb, more preferably
3,000ppb~6,000ppb.
In the present invention, the washing for the evaporation residue for being attached to nozzle and rapid steamer etc. is made to become good other acid
And/or salt can also be selected from the specified additive of food hygiene law.Specifically, it is preferable that L-AA and/or its salt, second
Ethylenediaminotetraacetate (edetate), citric acid and/or its salt, gluconic acid and/or its salt, Pidolidone and/or its salt, silicate, nitric acid
Salt, carbonate, pyrophosphate, sulfate, particularly preferred sulfate.
About aqueous hydrogen peroxide solution of the invention, evaporation residue amount be preferably 10ppm hereinafter, more preferably 8ppm with
Under.Evaporation residue amount in aqueous hydrogen peroxide solution can use method documented by JIS-K1463 and be measured.
About aqueous hydrogen peroxide solution of the invention, the washing removal rate in evaporator adhiesion test be preferably 40% with
On, more preferably 50% or more.It is aftermentioned in embodiment for the details of evaporator adhiesion test.
Aqueous hydrogen peroxide solution of the invention is in the form of mist or steam for sterilizing.Keep hydrogen peroxide of the invention water-soluble
The method that liquid gasifies and generates mist or steam is not particularly limited.For the details of method for disinfection, in the present specification after
It states.
The purposes of aqueous hydrogen peroxide solution of the invention is not particularly limited, and is preferred for the sterilization of container package material, device
Tool sterilization or space sterilization.
2. the method for disinfection of object
Method for disinfection of the invention is related to the method for disinfection of object, which is characterized in that makes aquae hydrogenii dioxidi of the invention
Solution is contacted in the form of mist or steam with object.About the details of aqueous hydrogen peroxide solution of the invention, institute as above
It states.
The method for making aqueous hydrogen peroxide solution gasify and generating mist or steam is not particularly limited, such as can enumerate utilization
The method of ultrasonic wave utilizes the method heated.It can be used alone the mist or steam of the obtained aqueous hydrogen peroxide solution,
Gas shape fluid can also be formed with other gas mixings and contact with object.Preferably by evaporator by aquae hydrogenii dioxidi
Solution is heated to boiling point or more and is vaporized, and the mist or steam of other gases and aqueous hydrogen peroxide solution are mixed, and is formed
Gas shape fluid and use.The device of aqueous hydrogen peroxide solution heating and gasifying is set to use well known dress without particular limitation
It sets.Used by mixed gas, even such as concaveconvex shape object, also can be more effectively water-soluble with hydrogen peroxide
The mist or steam of liquid contact.
As the concrete example for the gas that the mist or steam with above-mentioned aqueous hydrogen peroxide solution use simultaneously, sky can be enumerated
Gas, nitrogen, oxygen and ozone.In particular, since air is cheap, thus preferably.Temperature for mixed gas is preferably
It is more than room temperature.
When contacting the mist of aqueous hydrogen peroxide solution or steam with object, prefers to while the gas used also carries out
Heating.
The mist or steam of aqueous hydrogen peroxide solution or with the mist of the aqueous hydrogen peroxide solution after other gas mixings or
The temperature of gas shape fluid as steam is preferably 30~250 DEG C, more preferably 50 DEG C~200 DEG C, further preferably 100
DEG C~150 DEG C.By using within the scope of above-mentioned temperature, sufficient sterilizing ability can be obtained, and can effectively prevent
Only because of the damage of sterilization object object caused by heat.
As object, packing container, food machinery, PET bottle, PET bottle preform, laboratory apparatus, doctor may be exemplified
Instrument, sanitary apparatus, kitchen tools, food and space etc. are treated, but not limited to this.
As space, automobile, the toilet of used in electronic industry, living space, Medical space, kitchen, culinary art may be exemplified
Place, vehicle, aircraft etc., but not limited to this.
In the present invention, the generation device of the mist of aqueous hydrogen peroxide solution and/or steam can also be put into facility, is produced
The mist and/or steam of raw aqueous hydrogen peroxide solution, reduce the bacterium number in facility.
As the facility, bathroom facility, waste treatment facilities, animal house etc. may be exemplified, but not limited to this.
Embodiment
Then, the present invention is more specifically illustrated using embodiment and comparative example.But the present invention is not limited to
Under embodiment.
The stability of < hydrogen peroxide and the evaluation method > of evaporation remainder
The stability and evaporation remainder of hydrogen peroxide are evaluated using the method for JIS-K1463 defined.
The measurement > of < phosphoric acid and sulfate ion concentration
Phosphoric acid and sulfate ion concentration in aqueous hydrogen peroxide solution utilize ion chromatograph DX-500 (Dionex system
Make) it is measured.
< aluminum concentration >
Aluminum concentration in aqueous hydrogen peroxide solution utilizes 6000 (Thermo Fisher of ICP apparatus for analyzing luminosity iCAP
SCIENTIFIC manufacture) it is measured.
The evaluation > of < evaporator adhesion amount and washing property
Simulation evaporator is used so that well known evaporator is reference and reduces the evaporator simulated.Concentration of hydrogen peroxide 35%
Aqueous hydrogen peroxide solution sample mixed with air in the simulation evaporator for being heated to 300 DEG C on one side, on one side with certain speed
Liquor charging simultaneously gasifies, and test within 80 hours.When concentration of hydrogen peroxide is 25%, it is set as 112 hours.Simulation after measurement test is steamed
Send out the amount of thinking highly of, using with the weight difference before test as adhesion amount (mg).Then, it washed with ion exchange water, dried,
Measure weight again, using with the weight difference before test as residual quantity (mg).According to adhesion amount and residual quantity, calculated based on following formula
Removal rate (%) is washed in water outlet.
Wash removal rate (%)=[1- { residual quantity (mg)/adhesion amount (mg) }] × 100
(simulation evaporator construction)
Material: SUS304L
Size:The front end of cylinder-shaped vaporizer is equipped with the conical nozzle of height 17mm.Circular cone
Shape nozzle is provided with using front endHole nozzle.
(condition)
The liquor charging flow of aqueous hydrogen peroxide solution sample: 1.25mL/min
Air mass flow: 2.1L/min
Ion exchange water flow: 500ml/1.5min
The gaseous fluid temperature of jet hole: 100~120 DEG C
< SUS immersion test >
The test film (30mm × 30mm × 2mm) 2 of SUS304L is put into hydrogen peroxide water sample 300ml, 45
DEG C stand 24 hours.
1 > of < embodiment
After distillation purification, orthophosphoric acid (rear rattan chemistry strain is added into 35% aquae hydrogenii dioxidi to pure water adjustment concentration
The manufacture of formula commercial firm, phosphoric acid (concentration 85.0%)) 3 mass ppm, aluminum aluminum sulfate (Wako Pure Chemical Industries, Ltd.'s manufacture, aluminum sulfate
12 hydrate of potassium (concentration 96.5%)) 1 mass ppm, sodium sulphate (Wako Pure Chemical Industries, Ltd.'s manufacture, the hydration of sodium sulphate 10
Object (concentration 99.0%)) 0.5 mass ppm.Sulfate ion at this time/Al ratio is 14.The steaming of the aqueous hydrogen peroxide solution sample
Hair remainder is 6 mass ppm, and evaporator adhesion amount is 12.3mg, and the washing removal rate of attachment is 59%.
< embodiment 2-4 >
Change concentration of hydrogen peroxide, aluminum aluminum sulfate additive amount, sodium sulphate additive amount respectively, carries out same as Example 1
Experiment.Respective content is as described in Table 1.The sulfate ion of these aqueous hydrogen peroxide solution samples/Al ratio is 10~20
Range.The washing removal rate of evaporator attachment is 60% or so.
< comparative example 1-5 >
Change concentration of hydrogen peroxide, aluminum aluminum sulfate additive amount, sodium sulphate additive amount respectively, carries out same as Example 1
Experiment.Respective content is as described in Table 1.The sulfate ion of these aqueous hydrogen peroxide solution samples/Al ratio departing from 10~
20 range.The evaporator adhesion amount of these aqueous hydrogen peroxide solution samples sees deterioration in sample segment, in addition, washing
Removal rate becomes the result substantially reduced in whole samples.In addition, when stabilizer is phosphoric acid, the increase of adhesion amount and SUS
Stability decline after dipping is significant.
6 > of < comparative example
For comparative example 6, also respectively change concentration of hydrogen peroxide, aluminum aluminum sulfate additive amount, sodium sulphate additive amount, carry out with
The identical experiment of embodiment 1.Respective content is as described in Table 1.The sulfate radical of the aqueous hydrogen peroxide solution sample of comparative example 6 from
Son/Al ratio is in the range of 10~20, but ortho-phosphoric content has been more than 8ppm.In the sample, evaporator adhesion amount and water
Removal rate is washed to be degrading.
The results obtained are shown in table 1 and Fig. 1~3.
[table 1]
According to above-mentioned result it is found that passing through sulfate ion even if the total content of Al or the total content of stabilizer are few
Content is 10 times or more 20 times hereinafter, being also able to maintain that the stability of hydrogen peroxide, energy relative to the content of aluminium by quality ratio
Adhesion amount is enough reduced, washing removal rate (such as embodiment 1 and comparative example 2) is improved.
Industrial availability
Using the present invention, the stability of the hydrogen peroxide in aqueous hydrogen peroxide solution be can be improved, and is reduced attachment and is remained on
The attachment of the stabilizer in aqueous hydrogen peroxide solution of spray nozzle and evaporator etc., and can be using washing easily
Residue is removed, therefore, the thin of nonchoking nozzle etc. matches pipe portion, and aseptic filling device being capable of stable operation.
Claims (13)
1. a kind of aqueous solution is the aqueous hydrogen peroxide solution of the sterilization used in the form of mist or steam, the aqueous solution
It is characterized in that, contains:
Hydrogen peroxide；
2ppm or more 8ppm orthophosphoric acid below or phosphonic acids；
10ppb or more 500ppb aluminium below；With
Sulfate ion,
The content of the sulfate ion is 10 times or more 20 times or less relative to the content of the aluminium by quality ratio.
2. aqueous solution as described in claim 1, it is characterised in that:
The concentration of the hydrogen peroxide is 20 mass % or more, 45 mass % or less.
3. aqueous solution as claimed in claim 1 or 2, it is characterised in that:
Evaporation residue amount is 10ppm or less.
4. aqueous solution according to any one of claims 1 to 3, it is characterised in that:
Washing removal rate in evaporator adhiesion test is 40% or more.
5. aqueous solution as described in any one of claims 1 to 4, which is characterized in that contain:
2ppm or more 5ppm orthophosphoric acid below；With
50ppb or more 250ppb aluminium below.
6. such as aqueous solution according to any one of claims 1 to 5, it is characterised in that:
For the sterilization of container package material, utensil sterilization or space sterilization.
7. a kind of method for disinfection of object, it is characterised in that:
Contact aqueous solution according to any one of claims 1 to 6 in the form of mist or steam with object.
8. method for disinfection as claimed in claim 7, it is characterised in that:
The temperature of the mist or steam is 30 DEG C~250 DEG C.
9. method for disinfection as claimed in claim 7, it is characterised in that:
By the mist or steam and gas mixing, gas shape fluid is formed, and contacts the gas shape fluid with object.
10. method for disinfection as claimed in claim 9, it is characterised in that:
The gas is at least one kind of in air, nitrogen, oxygen and ozone.
11. the method for disinfection as described in any one of claim 7~10, it is characterised in that:
The object is packing container, food machinery, PET bottle, PET bottle preform, laboratory apparatus, medical instrument, health
Utensil, kitchen tools or food.
12. the method for disinfection as described in any one of claim 7~10, it is characterised in that:
The object is space.
13. method for disinfection as claimed in claim 12, it is characterised in that:
The space be automobile, the toilet of used in electronic industry, living space, Medical space, kitchen, culinary art place, vehicle or
Aircraft.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410108378.7A CN117941706A (en) | 2017-01-31 | 2017-12-25 | Aqueous hydrogen peroxide solution for sterilization |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017015708 | 2017-01-31 | ||
| JP2017-015708 | 2017-01-31 | ||
| PCT/JP2017/046351 WO2018142810A1 (en) | 2017-01-31 | 2017-12-25 | Hydrogen peroxide aqueous solution for disinfection |
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| CN202410108378.7A Division CN117941706A (en) | 2017-01-31 | 2017-12-25 | Aqueous hydrogen peroxide solution for sterilization |
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| CN110191640A true CN110191640A (en) | 2019-08-30 |
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| CN202410108378.7A Pending CN117941706A (en) | 2017-01-31 | 2017-12-25 | Aqueous hydrogen peroxide solution for sterilization |
| CN201780084068.4A Pending CN110191640A (en) | 2017-01-31 | 2017-12-25 | Aqueous hydrogen peroxide for sterilization solution |
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| CN202410108378.7A Pending CN117941706A (en) | 2017-01-31 | 2017-12-25 | Aqueous hydrogen peroxide solution for sterilization |
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| JP (2) | JPWO2018142810A1 (en) |
| KR (2) | KR20190111904A (en) |
| CN (2) | CN117941706A (en) |
| TW (1) | TWI789373B (en) |
| WO (1) | WO2018142810A1 (en) |
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| JPWO2022190894A1 (en) * | 2021-03-08 | 2022-09-15 | ||
| MX2023015002A (en) * | 2021-06-23 | 2024-02-15 | Evonik Corp | A process for sterilization treatment using a residue-free hydrogen peroxide. |
| JP7273441B1 (en) * | 2022-10-05 | 2023-05-15 | 株式会社エアレックス | Decontamination liquid, and decontamination equipment and decontamination method using the same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105377752A (en) * | 2013-07-18 | 2016-03-02 | 三菱瓦斯化学株式会社 | Aqueous hydrogen peroxide solution for disinfection applications, method for producing same, and disinfection method using same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4534945A (en) * | 1984-05-03 | 1985-08-13 | Fmc Corporation | Stabilization of high purity hydrogen peroxide |
| IT1251431B (en) * | 1991-10-25 | 1995-05-09 | Costante Fontana | COMPOUND WITH HIGH STABILIZING CHARACTERISTICS, PARTICULARLY FOR INORGANIC PEROXIDES USED IN INDUSTRIAL APPLICATIONS |
| JPH1135306A (en) * | 1997-07-17 | 1999-02-09 | Mitsubishi Gas Chem Co Inc | Hydrogen peroxide composition |
| JPH1147242A (en) * | 1997-07-31 | 1999-02-23 | Dainippon Printing Co Ltd | Disinfection apparatus for packaging material and disinfection method thereof |
| JP2006240969A (en) * | 2005-03-07 | 2006-09-14 | Mitsubishi Gas Chem Co Inc | Hydrogen peroxide water for aseptic packaging apparatus |
| JPWO2006123636A1 (en) * | 2005-05-19 | 2008-12-25 | 三菱瓦斯化学株式会社 | Hydrogen peroxide solution for sterilization |
| EP1762252A1 (en) | 2005-09-12 | 2007-03-14 | SOLVAY (Société Anonyme) | Aqueous solution suitable for the chemical sterilization of packaging materials, process for its preparation and its use |
| CN107105641B (en) * | 2015-01-16 | 2021-06-29 | 三菱瓦斯化学株式会社 | Bactericide and method of sterilizing using the same |
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2017
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- 2017-12-25 CN CN202410108378.7A patent/CN117941706A/en active Pending
- 2017-12-25 KR KR1020237002665A patent/KR20230017922A/en not_active Application Discontinuation
- 2017-12-25 CN CN201780084068.4A patent/CN110191640A/en active Pending
- 2017-12-25 JP JP2018565989A patent/JPWO2018142810A1/en not_active Withdrawn
- 2017-12-25 WO PCT/JP2017/046351 patent/WO2018142810A1/en active Application Filing
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2018
- 2018-01-24 TW TW107102452A patent/TWI789373B/en active
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2022
- 2022-07-04 JP JP2022107694A patent/JP2022130679A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105377752A (en) * | 2013-07-18 | 2016-03-02 | 三菱瓦斯化学株式会社 | Aqueous hydrogen peroxide solution for disinfection applications, method for producing same, and disinfection method using same |
Also Published As
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|---|---|
| KR20230017922A (en) | 2023-02-06 |
| CN117941706A (en) | 2024-04-30 |
| TW201832663A (en) | 2018-09-16 |
| KR20190111904A (en) | 2019-10-02 |
| TWI789373B (en) | 2023-01-11 |
| JPWO2018142810A1 (en) | 2019-11-14 |
| JP2022130679A (en) | 2022-09-06 |
| WO2018142810A1 (en) | 2018-08-09 |
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Application publication date: 20190830 |