CN110179009B - Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof - Google Patents
Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof Download PDFInfo
- Publication number
- CN110179009B CN110179009B CN201910502363.8A CN201910502363A CN110179009B CN 110179009 B CN110179009 B CN 110179009B CN 201910502363 A CN201910502363 A CN 201910502363A CN 110179009 B CN110179009 B CN 110179009B
- Authority
- CN
- China
- Prior art keywords
- parts
- natural plant
- laying hens
- raw material
- plant feed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000002994 raw material Substances 0.000 title claims abstract description 47
- 208000035240 Disease Resistance Diseases 0.000 title claims abstract description 31
- 150000001875 compounds Chemical class 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 241000196324 Embryophyta Species 0.000 claims abstract description 31
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 21
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 19
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 19
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 15
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 15
- 235000011477 liquorice Nutrition 0.000 claims abstract description 15
- 241000830535 Ligustrum lucidum Species 0.000 claims abstract description 14
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 12
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 9
- 241000125175 Angelica Species 0.000 claims description 8
- 241000736199 Paeonia Species 0.000 claims description 7
- 241000213006 Angelica dahurica Species 0.000 claims description 5
- 241001106477 Paeoniaceae Species 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 14
- 230000007774 longterm Effects 0.000 abstract description 5
- 230000004060 metabolic process Effects 0.000 abstract description 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 23
- 239000008280 blood Substances 0.000 description 23
- 230000000694 effects Effects 0.000 description 21
- 210000004072 lung Anatomy 0.000 description 15
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 208000010359 Newcastle Disease Diseases 0.000 description 11
- 230000006870 function Effects 0.000 description 10
- 230000001737 promoting effect Effects 0.000 description 10
- 238000011160 research Methods 0.000 description 10
- 238000005728 strengthening Methods 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 9
- 230000009471 action Effects 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000001717 pathogenic effect Effects 0.000 description 9
- 208000002193 Pain Diseases 0.000 description 8
- 230000017448 oviposition Effects 0.000 description 8
- 238000009395 breeding Methods 0.000 description 7
- 230000001488 breeding effect Effects 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 230000007812 deficiency Effects 0.000 description 7
- 235000013601 eggs Nutrition 0.000 description 7
- 210000002216 heart Anatomy 0.000 description 7
- 206010022000 influenza Diseases 0.000 description 7
- 238000004091 panning Methods 0.000 description 7
- 210000000952 spleen Anatomy 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- 235000019640 taste Nutrition 0.000 description 7
- 241000287828 Gallus gallus Species 0.000 description 6
- 235000013330 chicken meat Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 5
- 206010059866 Drug resistance Diseases 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 5
- 229960004949 glycyrrhizic acid Drugs 0.000 description 5
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 5
- 235000019410 glycyrrhizin Nutrition 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 230000000144 pharmacologic effect Effects 0.000 description 5
- 238000010926 purge Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- 239000004378 Glycyrrhizin Substances 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- 208000031971 Yin Deficiency Diseases 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229940124350 antibacterial drug Drugs 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 244000144992 flock Species 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 229930182470 glycoside Natural products 0.000 description 4
- -1 hydroxy paeoniflorin Chemical compound 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 4
- 210000001835 viscera Anatomy 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- NPNUFJAVOOONJE-ZIAGYGMSSA-N β-(E)-Caryophyllene Chemical compound C1CC(C)=CCCC(=C)[C@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-ZIAGYGMSSA-N 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 3
- 235000017443 Hedysarum boreale Nutrition 0.000 description 3
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 208000005392 Spasm Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000034994 death Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 150000002338 glycosides Chemical class 0.000 description 3
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 3
- 239000007952 growth promoter Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000036737 immune function Effects 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 239000001648 tannin Substances 0.000 description 3
- 235000018553 tannin Nutrition 0.000 description 3
- 229920001864 tannin Polymers 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- CWVRJTMFETXNAD-BMNNCGMMSA-N (1s,3r,4s,5r)-3-[(e)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid Chemical compound O[C@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-BMNNCGMMSA-N 0.000 description 2
- RIXNFYQZWDGQAE-DFHVBEEKSA-N (4as,6ar,6as,6br,8ar,10s,12ar,14bs)-10-acetyloxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound C([C@H]1C2=CC[C@H]34)C(C)(C)CC[C@]1(C(O)=O)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](OC(=O)C)C1(C)C RIXNFYQZWDGQAE-DFHVBEEKSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 2
- NVEQFIOZRFFVFW-UHFFFAOYSA-N 9-epi-beta-caryophyllene oxide Natural products C=C1CCC2OC2(C)CCC2C(C)(C)CC21 NVEQFIOZRFFVFW-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- LHXDLQBQYFFVNW-UHFFFAOYSA-N Fenchone Chemical compound C1CC2(C)C(=O)C(C)(C)C1C2 LHXDLQBQYFFVNW-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 239000009083 Fructus psoraleae extract Substances 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 208000018569 Respiratory Tract disease Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- FAMPSKZZVDUYOS-UHFFFAOYSA-N alpha-Caryophyllene Natural products CC1=CCC(C)(C)C=CCC(C)=CCC1 FAMPSKZZVDUYOS-UHFFFAOYSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- NPNUFJAVOOONJE-UHFFFAOYSA-N beta-cariophyllene Natural products C1CC(C)=CCCC(=C)C2CC(C)(C)C21 NPNUFJAVOOONJE-UHFFFAOYSA-N 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 229940117948 caryophyllene Drugs 0.000 description 2
- NPNUFJAVOOONJE-UONOGXRCSA-N caryophyllene Natural products C1CC(C)=CCCC(=C)[C@@H]2CC(C)(C)[C@@H]21 NPNUFJAVOOONJE-UONOGXRCSA-N 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 235000001368 chlorogenic acid Nutrition 0.000 description 2
- 229940074393 chlorogenic acid Drugs 0.000 description 2
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 2
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 2
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- VFPFQHQNJCMNBZ-UHFFFAOYSA-N ethyl gallate Chemical compound CCOC(=O)C1=CC(O)=C(O)C(O)=C1 VFPFQHQNJCMNBZ-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 229930182486 flavonoid glycoside Natural products 0.000 description 2
- 150000007955 flavonoid glycosides Chemical class 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- KRZBCHWVBQOTNZ-DLDRDHNVSA-N isochlorogenic acid Natural products O[C@@H]1[C@H](C[C@@](O)(C[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)C(=O)O)OC(=O)C=Cc3ccc(O)c(O)c3 KRZBCHWVBQOTNZ-DLDRDHNVSA-N 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LHXDLQBQYFFVNW-XCBNKYQSSA-N (+)-Fenchone Natural products C1C[C@]2(C)C(=O)C(C)(C)[C@H]1C2 LHXDLQBQYFFVNW-XCBNKYQSSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N 3‐isothujone Chemical compound CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- LATYEZNGPQKAIK-UHFFFAOYSA-N 6'-O-benzoylpaeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(COC(=O)C=6C=CC=CC=6)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 LATYEZNGPQKAIK-UHFFFAOYSA-N 0.000 description 1
- CZVCGJBESNRLEQ-UHFFFAOYSA-N 7h-purine;pyrimidine Chemical compound C1=CN=CN=C1.C1=NC=C2NC=NC2=N1 CZVCGJBESNRLEQ-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- QQUHMASGPODSIW-UHFFFAOYSA-N Albiflorin Natural products C=1C=CC=CC=1C(=O)OCC12C(=O)OC3(C)CC(O)C1CC32OC1OC(CO)C(O)C(O)C1O QQUHMASGPODSIW-UHFFFAOYSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- LATYEZNGPQKAIK-HRCYFWENSA-N Benzoylpaeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C=2C=CC=CC=2)O1)O)C)OC(=O)C1=CC=CC=C1 LATYEZNGPQKAIK-HRCYFWENSA-N 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- 239000004262 Ethyl gallate Substances 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- XYXONTIQGZKCNH-UYKXVWJOSA-N Lonicerin Natural products CO[C@@H]1O[C@@H](O)[C@H]([C@H]2C[C@H](O)[C@H](C)[C@@H]12)C(=O)OC XYXONTIQGZKCNH-UYKXVWJOSA-N 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010062575 Muscle contracture Diseases 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 231100000674 Phytotoxicity Toxicity 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241001446509 Psoralea Species 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- SHPPXMGVUDNKLV-UHFFFAOYSA-N Veronicastroside Natural products OC1C(O)C(O)C(C)OC1OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 SHPPXMGVUDNKLV-UHFFFAOYSA-N 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- QQUHMASGPODSIW-ICECTASOSA-N albiflorin Chemical compound O([C@@]12C[C@H]3[C@H](O)C[C@@]1(OC(=O)[C@]32COC(=O)C=1C=CC=CC=1)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QQUHMASGPODSIW-ICECTASOSA-N 0.000 description 1
- VIWQCBZFJFSCLC-UHFFFAOYSA-N alpha-benzoyloxypaeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(COC(=O)C=6C=CC=CC=6)O5)O)CC3(O)OC1C24COC(=O)C1=CC=C(O)C=C1 VIWQCBZFJFSCLC-UHFFFAOYSA-N 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- HITDPRAEYNISJU-UHFFFAOYSA-N amenthoflavone Natural products Oc1ccc(cc1)C2=COc3c(C2=O)c(O)cc(O)c3c4cc(ccc4O)C5=COc6cc(O)cc(O)c6C5=O HITDPRAEYNISJU-UHFFFAOYSA-N 0.000 description 1
- YUSWMAULDXZHPY-UHFFFAOYSA-N amentoflavone Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C(C=3C(=CC=C(C=3)C=3OC4=CC(O)=CC(O)=C4C(=O)C=3)O)=C2O1 YUSWMAULDXZHPY-UHFFFAOYSA-N 0.000 description 1
- HVSKSWBOHPRSBD-UHFFFAOYSA-N amentoflavone Natural products Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)c4cc(ccc4O)C5=COc6cc(O)cc(O)c6C5=O HVSKSWBOHPRSBD-UHFFFAOYSA-N 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 229940031567 attenuated vaccine Drugs 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 208000006111 contracture Diseases 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 150000001893 coumarin derivatives Chemical class 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000019277 ethyl gallate Nutrition 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 239000010685 fatty oil Substances 0.000 description 1
- 229930006735 fenchone Natural products 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000000777 hematopoietic system Anatomy 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- WTDHMFBJQJSTMH-UHFFFAOYSA-N hinokiflavone Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C(OC=3C=CC(=CC=3)C=3OC4=CC(O)=CC(O)=C4C(=O)C=3)=C(O)C=C2O1 WTDHMFBJQJSTMH-UHFFFAOYSA-N 0.000 description 1
- HLFVFEBKCLAGBY-UHFFFAOYSA-N hinokiflavone Natural products Oc1ccc(cc1)C2=COc3cc(O)c(Oc4ccc(cc4)C5=CC(=O)c6c(O)cc(O)cc6O5)c(O)c3C2=O HLFVFEBKCLAGBY-UHFFFAOYSA-N 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000003832 immune regulation Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- DXDRHHKMWQZJHT-FPYGCLRLSA-N isoliquiritigenin Chemical compound C1=CC(O)=CC=C1\C=C\C(=O)C1=CC=C(O)C=C1O DXDRHHKMWQZJHT-FPYGCLRLSA-N 0.000 description 1
- 235000008718 isoliquiritigenin Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- PEFNSGRTCBGNAN-QNDFHXLGSA-N luteolin 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 PEFNSGRTCBGNAN-QNDFHXLGSA-N 0.000 description 1
- SHPPXMGVUDNKLV-KMFFXDMSSA-N luteolin 7-O-neohesperidoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 SHPPXMGVUDNKLV-KMFFXDMSSA-N 0.000 description 1
- SUTSVCLKBLJSPQ-UHFFFAOYSA-N luteolin 7-glucoside Natural products OC1C(O)C(O)C(CO)OC1C1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 SUTSVCLKBLJSPQ-UHFFFAOYSA-N 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- BFBPISPWJZMWJN-UHFFFAOYSA-N methyl 2-[(7-hydroxy-3,7-dimethyloctylidene)amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1N=CCC(C)CCCC(C)(C)O BFBPISPWJZMWJN-UHFFFAOYSA-N 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 230000008621 organismal health Effects 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- NQJGJBLOXXIGHL-UHFFFAOYSA-N podocarpusflavone A Natural products COc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)c4cc(ccc4O)C5=COc6cc(O)cc(O)c6C5=O NQJGJBLOXXIGHL-UHFFFAOYSA-N 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- GWTUHAXUUFROTF-UHFFFAOYSA-N pseudochlorogenic acid Natural products C1C(O)C(O)C(O)CC1(C(O)=O)OC(=O)C=CC1=CC=C(O)C(O)=C1 GWTUHAXUUFROTF-UHFFFAOYSA-N 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229930007110 thujone Natural products 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- CWVRJTMFETXNAD-NXLLHMKUSA-N trans-5-O-caffeoyl-D-quinic acid Chemical compound O[C@H]1[C@H](O)C[C@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-NXLLHMKUSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of feeding natural plant feed raw materials, and particularly discloses a feeding natural plant feed raw material compound for improving the disease resistance of laying hens and a preparation method thereof. The composite material is prepared from the following raw materials in parts by weight: 40-65 parts of red peony root, 40-75 parts of rhizoma anemarrhenae, 15-35 parts of honeysuckle, 15-40 parts of cacumen biotae, 15-35 parts of glossy privet fruit, 15-35 parts of angelica, 10-25 parts of rhizoma polygonati, 10-25 parts of fructus psoraleae and 10-20 parts of liquorice. According to the invention, through long-term tests, the natural plant feed raw material compound for feeding capable of improving the disease resistance of the laying hens is screened out, and the natural plant feed raw material compound for feeding capable of improving the disease resistance of the laying hens is finally prepared by combining the physiological metabolism characteristics of the laying hens.
Description
Technical Field
The invention belongs to the technical field of natural plant feed raw materials for feeding, and particularly relates to a natural plant feed raw material compound for improving the disease resistance of laying hens and a preparation method thereof.
Background
In 6 months in 2017, the department in agricultural rural areas issues a notification of nationwide animal resistance suppression action plans (2017-2020): number 22 of the patent No. 2017. The file explicitly states: in order to meet the drug resistance challenge of animal-derived bacteria, improve the scientific management level of veterinary antibacterial drugs, guarantee the production safety, food safety, public health safety and ecological safety of the breeding industry, maintain the health of people, promote the sustainable health development of the economic society, and gradually withdraw from the process by' pushing the veterinary antibacterial drugs to be used in a reduction way, and using the antibacterial drugs shared by people and animals or the antibacterial drugs which are easy to generate cross drug resistance as animal growth promoters; the growth trend of the drug resistance rate of the animal-derived main bacteria is effectively controlled' as a second action target of the action plan.
With the improvement of national requirements on the production safety, food safety, public health safety and ecological safety of the breeding industry, the antibacterial growth promoters which are commonly used by people and animals in the feed or are easy to generate cross drug resistance are gradually withdrawn. The antibacterial growth promoter in the laying hen feed can promote the growth of animals and can also obviously improve the disease resistance of laying hens. Therefore, with the implementation of the nationwide action plan for inhibiting the drug resistance of animal-derived bacteria, new feed raw materials or feed additives capable of improving the disease resistance of the laying hens are urgently needed to be added into the laying hen feed so as to solve the common disease problems in the laying hen breeding process, and particularly improve the disease resistance of the laying hens in the laying period.
When the inventor is dedicated to searching natural plant feed raw materials for improving the disease resistance of the laying hens, a natural plant feed raw material compound for improving the disease resistance of the laying hens is designed according to the physiological structure characteristics of the laying hens, the action mechanism of medicine-food homologous natural plant feed, the animal nutrition theory and the feed theory, so that healthy and green eggs meeting the food safety can be provided for consumers.
Disclosure of Invention
The invention aims to provide a natural plant feed raw material compound for improving the disease resistance of laying hens and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a natural plant feed raw material compound for improving the disease resistance of laying hens is prepared from the following raw materials in parts by weight: 40-65 parts of red peony root, 40-75 parts of rhizoma anemarrhenae, 15-35 parts of honeysuckle, 15-40 parts of cacumen biotae, 15-35 parts of glossy privet fruit, 15-35 parts of angelica, 10-25 parts of rhizoma polygonati, 10-25 parts of fructus psoraleae and 10-20 parts of liquorice.
Preferably, the composition is prepared from the following raw materials in parts by weight: 50 parts of red peony root, 60 parts of rhizoma anemarrhenae, 25 parts of honeysuckle, 30 parts of cacumen biotae, 25 parts of glossy privet fruit, 20 parts of angelica, 15 parts of rhizoma polygonati, 15 parts of fructus psoraleae and 15 parts of liquorice.
Preferably, the composition is prepared from the following raw materials in parts by weight: 60 parts of red peony root, 75 parts of rhizoma anemarrhenae, 20 parts of honeysuckle, 25 parts of cacumen biotae, 20 parts of glossy privet fruit, 25 parts of angelica, 15 parts of rhizoma polygonati, 15 parts of fructus psoraleae and 15 parts of liquorice.
Preferably, the composition is prepared from the following raw materials in parts by weight: 45 parts of red paeony root, 55 parts of rhizoma anemarrhenae, 30 parts of honeysuckle flower, 35 parts of cacumen biotae, 30 parts of glossy privet fruit, 30 parts of Chinese angelica, 20 parts of rhizoma polygonati, 10 parts of fructus psoraleae and 15 parts of liquorice.
The scheme has the main functions of clearing heat and detoxicating, cooling blood and nourishing yin, and clearing and tonifying, mainly clearing heat and detoxicating, cooling blood and stopping bleeding, and supplementing blood and nourishing yin, and eliminating pathogenic factors and strengthening body resistance to restore the health state of the organism. Laying hens belong to poultry, have light natures, have sweet and warm meat, and are mostly subjected to heat change when encountering pathogens, so the sub-health state of the laying hens is mainly based on thermal imagery, and the laying hens continuously pass body fluids, qi and blood of organisms due to the high production performance of the laying hens, so that the laying hens form constitution of yin deficiency. Therefore, the disease resistance of the laying hens is improved, the sub-health state of the laying hens is eliminated, starting from heat and deficiency, and the heat clearing and yin nourishing are the main directions. Therefore, the heat-clearing medicines such as the red paeony root, the rhizoma anemarrhenae, the honeysuckle, the cacumen biotae and the like are used in the scheme, and the glossy privet fruit, the Chinese angelica, the rhizoma polygonati and the like are used for nourishing yin and blood, so that the effects of eliminating pathogenic factors, strengthening body resistance, clearing and tonifying are achieved together, and the health of the organism is recovered.
Red peony root, bitter in taste and slightly cold in nature, enters liver channel, has the effects of promoting blood circulation by removing blood stasis, clearing heat and cooling blood, and is mainly used for treating blood heat and stasis; macula and fever due to invasion of warm-heat into blood, and hematemesis and epistaxis due to recklessly blood flow due to blood heat; acute inflammation of sore, carbuncle, swelling and pain. Radix Paeoniae Rubra contains paeoniflorin, hydroxy paeoniflorin, albiflorin, benzoylpaeoniflorin, benzoic acid, tannin, fatty oil, resin, sugar, starch, mucus, protein, paeonol, benzoic acid, radix Paeoniae Rubra A, radix Paeoniae Rubra B, Gallic acid Ethyl gallate, etc. The red paeony root is used for promoting blood circulation to remove blood stasis and improving the disease resistance of the laying hens; on the other hand, the composition is used for clearing heat, cooling blood, activating blood and preventing and treating the warm and hot diseases of the laying hens with pathogenic qi in blood.
Rhizoma anemarrhenae, bitter and sweet in taste and cold in nature, enters lung, stomach and kidney meridians, and has the effects of clearing heat and purging fire, nourishing yin and moistening dryness. Rhizoma anemarrhenae is a product for treating upper-middle-lower triple energizer, has floating in the middle-jiao and ascending in the middle-jiao, can clear and descend lung qi upwards to purge lung fire, moisten lung dryness, remove dysphoria with smothery sensation and relieve cough, and is used for treating warm diseases, pathogenic qi in qi system, and syndromes of yin deficiency and dry cough or lung heat cough; has effects in clearing away stomach fire and relieving polydipsia, and can be used for treating various syndromes in diabetes; it can purge ministerial fire and nourish kidney yin when it moves downwards, and is indicated for hyperactivity of fire due to yin deficiency, hectic fever due to yin deficiency, night sweat, etc. Rhizoma anemarrhenae mainly contains saponin. On one hand, the rhizoma anemarrhenae is used for moistening lung dryness, nourishing kidney yin and improving the disease resistance of the laying hens; on the other hand, the composition can clear heat and purge fire, and prevent and treat warm and hot diseases of the laying hens with pathogenic qi in the qi system.
Honeysuckle flower, sweet in taste, slightly bitter in flavor and cold in nature, enters lung, stomach, large intestine and heart channels, and has the effects of clearing heat and removing toxicity, cooling blood and stopping dysentery. Flos Lonicerae is used for treating affection of exogenous wind-heat, early stage of warm disease, pathogenic factors in qi system, and heat in upper energizer; it can also be used for treating syndrome of fire toxin; it is also indicated for warm-heat dysentery with toxic heat. The flos Lonicerae contains more than thirty kinds of volatile oils (mainly comprising linalool, geraniol, nerol, benzyl alcohol, floridol, myrcene, caryophyllene, etc.), various glycosides (lonicerin, saponin, flavonoid glycoside, luteolin-7-glucoside, etc.), chlorogenic acid, isochlorogenic acid, neochlorogenic acid, inositol, amino acid, quinic acid, tannin, saccharide, etc., wherein chlorogenic acid, isochlorogenic acid, luteolin are main effective components for resisting bacteria; in addition, it also contains ions such as calcium, iron, magnesium, zinc, and sodium. « the Chinese herbal medicines are recorded in the mobile phone, and the honeysuckle is sweet in taste, warm, nontoxic, light in weight after long-term taking and long-lasting in life. Meanwhile, the honeysuckle has prominent effects of protecting the liver and benefiting the gallbladder. Therefore, the honeysuckle can be used for improving the disease resistance of the laying hens; meanwhile, modern pharmacological research shows that: the honeysuckle has the function of resisting pathogenic microorganisms; anti-inflammatory and antipyretic effects; immune regulation effect; preventing gastric ulcer, etc.
The cacumen biotae is bitter and astringent in taste and slightly cold in nature, enters the lung, heart, liver and large intestine channels, and has the effects of cooling blood, stopping bleeding, clearing heat, relieving cough, dispelling wind, promoting diuresis, dispersing swelling and toxin, growing hair and blackening hair. Folium Platycladi contains coniferyl picrorhizine, thujone, quercetin, fenchone, volatile oil, caryophyllene, tannin, resin, hinokiflavone, amentoflavone, aurantiol, and myricetin. Ce Bai Ye is good herb for cooling blood and stopping bleeding, mainly for hematemesis, epistaxis, dysentery blood, and is very commonly used clinically for reducing weight and tonifying qi. Meanwhile, modern pharmacological research shows that: the folium Platycladi has antibacterial and antiviral effects. Therefore, the cacumen biotae is used for improving the disease resistance of the body of the laying hens on one hand and preventing various diseases in the laying hen breeding process on the other hand.
The glossy privet fruit, sweet and bitter in taste, cool in nature, enters liver and kidney meridians. « Shennong herbal is recorded in the mobile phone, fructus Ligustri Lucidi "invigorate the middle-jiao, tranquilize the five internal organs, nourish the spirit, eliminate diseases, and nourish the body after long-term administration. It has the functions of nourishing liver and kidney, improving eyesight and blackening hair. Modern research shows that: the fructus Ligustri Lucidi contains oleanolic acid, acetyl oleanolic acid, fructus Ligustri Lucidi glycoside, oleic acid, linoleic acid, palmitic acid, mannitol, glucose, etc. The modern pharmacological action research shows that: fructus Ligustri Lucidi has effects of enhancing humoral immunity and cellular immunity. The glossy privet fruit is used in the application, and the sub-health state of the chicken flocks is recovered under the intensive breeding condition by utilizing the efficacy of the glossy privet fruit in improving immunity and disease resistance.
Dang Gui is sweet and pungent in flavor and warm in nature, and enters heart, lung and liver meridians. Radix Angelicae sinensis has effects in promoting blood circulation, nourishing blood, relieving pain, regulating menstruation, and loosening bowel to relieve constipation. « famous medical records in the mobile phone: chinese angelica has the functions of warming middle energizer to relieve pain, removing obstruction in blood, treating apoplexy, spasm, sweating, damp arthralgia, middle jiao and qi deficiency, nourishing five internal organs and promoting granulation. « Ben Cao gang mu Tu recorded: chinese angelica root, radix Angelicae sinensis is used for treating headache, pain of heart and abdomen, moistening intestines, stomach, tendons, bones and skin; for abscess and deep-rooted carbuncle, pus discharge and pain, blood circulation and blood tonification. Modern research shows that: the radix Angelicae sinensis contains ferulic acid, succinic acid, nicotinic acid, uracil, purine pyrimidine, polysaccharide, sucrose, amino acid, and vitamin B2Trace elements of Mn, Ni and Cu, and vitamin ELinoleic acid and volatile oil. The polysaccharide component of radix Angelicae sinensis contains D-glucose and D-xylose. The pharmacological action is mainly embodied in cardiovascular, immune, uterine and antibacterial action. The angelica polysaccharide has the functions of promoting immunologic function, promoting hematopoietic system, resisting tumor and resisting radiation damage. Therefore, the angelica can be used for improving the immune function and disease resistance of the laying hens in the application; meanwhile, the feed has the effects of reducing the morbidity of laying hens in the body, promoting the sub-health recovery of the body and the like.
Huang Jing is sweet in flavor and neutral in nature and enters spleen, lung and kidney meridians. « famous medical records in the mobile phone: rhizoma polygonati is mainly used for tonifying middle-jiao and Qi, eliminating wind and dampness, calming five internal organs, reducing weight and prolonging life after long-term taking. « Rihuazi herbal medicine for the treatment of diabetes mellitus: rhizoma Polygonati has effects in tonifying five strains and seven injuries, promoting bones and muscles, relieving hunger, resisting cold and summer heat, invigorating spleen and stomach, and moistening heart and lung. Modern research shows that: rhizoma Polygonati contains nicotinic acid, mucus, starch, saccharide, amino acids, and anthraquinone compounds. Rhizoma Polygonati has the functions of invigorating qi, nourishing yin, and nourishing essence and blood, and is the essential herb for treating deficiency of both qi and yin of spleen and lung and deficiency of essence and blood. Sealwort has been regarded as a tonic, body-building and life-prolonging product from old times. Experimental research proves that: rhizoma Polygonati has effects of prolonging life of Bombyx mori, inhibiting lipid peroxidation, enhancing immunity, and improving cardiopulmonary function. Therefore, the purpose of using rhizoma polygonati in the application is the same as that of glossy privet fruit, and the subhealth state of chicken flocks under the intensive culture condition is recovered by utilizing the efficacy of promoting immunity and disease resistance of rhizoma polygonati.
Bu Gu Zhi has pungent and bitter taste, warm property, and has the actions of tonifying kidney, strengthening yang, warming spleen and checking diarrhea. « Ben Cao gang mu Tu recorded: bu Gu Zhi is indicated for kidney purge, gate of life, warming Dan Tian and astringing spirit. « the phytotoxicity mobile phone is recorded as follows: bu Gu Zhi is pungent and warm and enters kidney and large intestine; to relieve yang, stop kidney-qi, secure essence and relieve lumbago; warming up causes retention of water, so the essential herbs for strengthening fire and benefiting water also. Modern research shows that: fructus Psoraleae contains volatile oil, resin, coumarin derivatives, psoralen, isobavalanin, flavonoids, psoralen B, organic acid methyl glycoside, and saponin. Psoralea fruit, also known as fructus psoraleae paper, is recorded in « herbal compendium for mobile: taken together with Juglandis, has effects of prolonging life, invigorating qi, improving eyesight, and strengthening tendons and bones. Experimental studies also show that: has anti-aging effect, and is a common medicine for treating senile diseases. Therefore, the purpose of using fructus psoraleae in the application is the same as that of fructus ligustri lucidi, and the effect of improving immunity and disease resistance is utilized to recover the sub-health state of chicken flocks under intensive breeding conditions.
Licorice root, radix Glycyrrhizae is sweet and neutral in flavor, and enters the heart, lung, spleen and stomach meridians. The liquorice has the functions of tonifying qi and strengthening middle warmer, clearing away heat and toxic materials, relieving spasm and pain, and eliminating phlegm and relieving cough. « Shennong herbal is recorded in the mobile phone: licorice root, radix Glycyrrhizae is responsible for the pathogenic factors of internal organs, cold and heat, strengthening the muscles and bones, strengthening the muscles, strengthening the strength, swelling and removing toxicity of incised wound. The traditional Chinese medicine is mainly used for treating heart qi and spleen and stomach qi deficiency clinically; carbuncle, cellulitis, sore and ulcer, and sore throat; contracture and acute pain in the abdomen; cough and dyspnea. Modern research shows that: the main components of licorice can be divided into three categories: triterpenes glycyrrhizin (glycyrrhizic acid, glycyrrhizin) and glycyrrhetinic acid; flavones, flavonoid glycoside glycyrrhizin, flavone glycoside isoliquiritigenin, and licone; sugars, reducing sugars, starches. Meanwhile, new ingredients are continuously discovered in the year. The pharmacological action research shows that: the liquorice has obvious effect on the immunologic function; ammonium glycyrrhizinate can increase the number of peripheral white blood cells of mice, improve the phagocytic function of the white blood cells, and obviously promote a mononuclear phagocyte system, thereby improving the defense function of organisms. Glycyrrhizin Q and LH can increase TH amount and enhance cellular immunity. In addition, licorice root has a regulating effect on digestive systems. Meanwhile, the liquorice also has the effects of detoxifying, relieving cough, easing pain and the like. The liquorice is sweet in taste and neutral in nature, has various effects of tonifying spleen and qi, moistening lung and relieving cough, harmonizing drug properties, clearing heat and removing toxicity, can be called as the most widely applied traditional Chinese medicine in clinical application, can strengthen body resistance, eliminate pathogenic factors and pass through twelve meridians, so the liquorice can be used for treating heart-yang deficiency, spleen-stomach deficiency, lung deficiency and cough, diarrhea and dysentery abdominal pain, limb spasm and urgency, sore throat, sore and sore ulcer and pyogenic infections and the like. Therefore, the liquorice used in the application has the purpose of strengthening body resistance and also has the effect of eliminating pathogenic factors, so that the immunity of the laying hens is improved, the clinical morbidity of the laying hens is obviously reduced, and the sub-health state of the chicken flocks is promoted to be recovered under the intensive breeding condition.
All the feed raw materials are crushed and sieved, and after being eaten by laying hens, the feed raw materials are absorbed through a series of metabolic activities in vivo, so that the effect of improving the disease resistance of the laying hens is attempted to be realized.
The preparation method comprises the following steps: respectively crushing all the raw materials and then uniformly mixing or firstly uniformly mixing and then crushing together to prepare the natural plant feed raw material compound for feeding.
Preferably, the powder is crushed to pass through a 60-120 mesh sieve.
The using method comprises the following steps: the natural plant feed raw material compound is added into the complete ration of the laying hens in the laying period according to the weight ratio of 0.3-0.5%, and the laying hens are fed freely and continuously for 5-15 days.
According to the invention, through long-term tests, the natural plant feed raw material compound capable of improving the disease resistance of the laying hens is screened out, and the natural plant feed raw material compound product for reducing the clinical morbidity of the laying hens is finally prepared by combining the physiological metabolism characteristics of the laying hens, so that a relatively economical and easy method is provided for the food safety of egg products.
Drawings
FIG. 1: the results were compared to the total number of dead panning in each group.
Detailed Description
The present invention will be further described with reference to the following specific examples. It is to be understood that the following examples are illustrative of the present invention only and are not intended to limit the scope of the present invention.
A natural plant feed raw material compound for improving the disease resistance of laying hens is prepared from natural plant feed raw materials in parts by weight shown in Table 1.
The preparation method of the natural plant feed raw material compound in each embodiment and the comparative example comprises the following steps: weighing the raw materials according to the weight parts shown in the table 1, respectively crushing the raw materials to be completely sieved by a sieve of 80 meshes, and then uniformly mixing the raw materials to prepare mixed powder, namely the natural plant feed raw material compound for improving the disease resistance of the laying hens.
Clinical effects
1 materials and methods
1.1 test Natural plant feed stock complexes are the products of examples 1-3 and comparative examples 1-3.
1.2 preparing daily ration according to NRC Roman layer feeding standard, preparing basic daily ration, wherein the composition and the nutrition level of the daily ration are shown in Table 2.
1.3 test consumables: newcastle disease standard antigen, influenza H9 antigen, 96-well V-shaped plate, 50 μ L, 1000 μ L pipette, centrifuge tube, chicken red blood cell, PBS liquid, etc.
1.3 test animals: 12000 Roman laying hens aged 150 days. From the age of 150 days, the Newcastle disease attenuated vaccine (La Sota strain) is immunized once every 30 days by drinking water, and the newcastle disease bivalent inactivated vaccine (La Sota strain + LG1 strain) is immunized once every 60 days by intramuscular injection
1.4 experimental design and grouping: dividing 10500 Roman laying hens aged 150 days into seven groups according to the positions of henhouses, wherein each group comprises 1500, and the I group comprises: the basic ration plus the product of the invention in the embodiment 1 (added according to 0.3 wt percent of the basic ration) is continuously added for 10 days (freely taken), and the mixture is stopped for 20 days and sequentially alternated; group II: the basic ration plus the product of the invention in the embodiment 2 (added according to 0.3 wt percent of the basic ration) is continuously added for 10 days (freely taken), and the mixture is stopped for 20 days and sequentially alternated; group III: the basic ration plus the product of the invention in the embodiment 3 (added according to 0.3 wt percent of the basic ration) is continuously added for 10 days (freely taken), and the mixture is stopped for 20 days and sequentially alternated; group IV: the basic ration plus the product of comparative example 1 of the present invention (added in an amount of 0.3 wt% of the basic ration) was continuously added for 10 days (free feeding), and the feeding was stopped for 20 days, followed by rotation; group V: the basic ration plus the product of comparative example 2 of the present invention (added in an amount of 0.3 wt% of the basic ration) was continuously added for 10 days (free feeding), and the feeding was stopped for 20 days, followed by rotation; group VI: the basic ration plus the product of comparative example 3 of the present invention (added in an amount of 0.3 wt% of the basic ration) was continuously added for 10 days (free feeding), and the feeding was stopped for 20 days, followed by rotation; group VII (blank): basal diet was added continuously for 10 days (free feeding), stopped for 20 days, and alternated sequentially.
1.5 detection index and method
1.5.1 groups were monitored for newcastle disease resistance, influenza H9 body levels: seven groups of eggs were collected on days 30, 60, 90, 120, 150, 180, 210, and 240, respectively, and 10 eggs were randomly selected from each group, and the antibody levels of newcastle disease and influenza H9 in the eggs were measured using a hemagglutination inhibition test.
1.5.2 testing the production performance of each group: the number of dead and washed chickens, laying rate and egg weight on each day were counted on 30 th, 60 th, 90 th, 120 th, 150 th, 180 th, 210 th and 240 th days, respectively.
1.5.3 frequency of onset recording: the number of times of onset, the chief symptoms of onset and the medication record of each group were recorded for 240 days from the start to the end of the test.
1.6 data statistics and processing
1.6.1 antibody detection data: calculating the average value of the detection results of the newcastle disease antibodies in each group every month, and comparing the detection results of the newcastle disease antibodies in each group; the results of the detection of the H9 antibody level per month for each group were averaged and compared for each group.
1.6.2 Productivity data: the data statistics of the total death and culling quantity, the average egg laying rate per month, the average egg laying weight per month and the average egg laying weight per day of each group during the test period are drawn into a table/graph for comparison.
2 results of the test
2.1 Newcastle disease and influenza H9 antibody levels
The results of the comparison of the antibody levels of newcastle disease and influenza H9 in each group are shown in tables 3 and 4, respectively, and the test results show that: there was no significant difference between newcastle disease antibody levels and influenza H9 antibody levels in groups I, II, III compared to groups IV, V, VI, VII, respectively. The scheme of the invention has no obvious effect on improving the levels of the Newcastle disease and influenza H9 antibodies.
2.2 laying rate and average daily egg weight
The results of comparison of the laying rates of the groups and the daily average egg laying weights are shown in tables 5 and 6, respectively, and are shown in tables 5 and 6: from day 150, the laying rates and daily average egg laying weights of the group I, the group II and the group III are obviously higher than those of the group IV, the group V, the group VI and the group VII, the laying rate is improved by about 2% -3%, and the daily average egg laying weight is improved by about 2% -3 g.
2.3 Total mortality
The comparison of the total dead panning numbers of each group is shown in FIG. 1, and it can be seen from FIG. 1 that: in 240 days of the whole experiment, the total dead panning numbers of the I, II and III groups are between 28 and 39, while the total dead panning numbers of the IV, V and VI groups reach between 61 and 77, and the total dead panning number of the VII group reaches 168. The death panning numbers of the groups I, II and III are obviously lower than those of the groups IV, V, VI and VII; the scheme of the invention can effectively reduce the dead panning number of the laying hens in the laying period.
2.4 onset and dosing status of groups during the test period
The onset and dosing of each group during the test are shown in Table 7, and it can be seen from Table 7: within 240 days of the whole experiment, the group I, the group II and the group III have no diseases, the group IV and the group VI have one intestinal tract disease, the group V has 2 intestinal tract diseases and 1 respiratory tract disease, and the group VII has 3 intestinal tract diseases and 1 respiratory tract disease. The test results show that the scheme of the invention can effectively prevent intestinal diseases and respiratory diseases.
3. Conclusion
3.1 by using the natural plant feed raw material compound, the daily average egg laying weight of the laying hens in the egg laying period can be effectively improved;
3.2 the natural plant feed raw material compound can greatly reduce the death and culling number of the laying hens in the laying period;
3.3 the natural plant feed raw material compound can effectively reduce the incidence of intestinal diseases and respiratory diseases.
Claims (6)
1. A natural plant feed raw material compound for improving the disease resistance of laying hens is characterized by being prepared from the following raw materials in parts by weight: 40-65 parts of red peony root, 40-75 parts of rhizoma anemarrhenae, 15-35 parts of honeysuckle, 15-40 parts of cacumen biotae, 15-35 parts of glossy privet fruit, 15-35 parts of angelica, 10-25 parts of rhizoma polygonati, 10-25 parts of fructus psoraleae and 10-20 parts of liquorice.
2. The natural plant feed raw material compound for improving the disease resistance of laying hens as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 50 parts of red peony root, 60 parts of rhizoma anemarrhenae, 25 parts of honeysuckle, 30 parts of cacumen biotae, 25 parts of glossy privet fruit, 20 parts of angelica, 15 parts of rhizoma polygonati, 15 parts of fructus psoraleae and 15 parts of liquorice.
3. The natural plant feed raw material compound for improving the disease resistance of laying hens as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 60 parts of red peony root, 75 parts of rhizoma anemarrhenae, 20 parts of honeysuckle, 25 parts of cacumen biotae, 20 parts of glossy privet fruit, 25 parts of angelica, 15 parts of rhizoma polygonati, 15 parts of fructus psoraleae and 15 parts of liquorice.
4. The natural plant feed raw material compound for improving the disease resistance of laying hens as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 45 parts of red paeony root, 55 parts of rhizoma anemarrhenae, 30 parts of honeysuckle flower, 35 parts of cacumen biotae, 30 parts of glossy privet fruit, 30 parts of Chinese angelica, 20 parts of rhizoma polygonati, 10 parts of fructus psoraleae and 15 parts of liquorice.
5. A method for preparing the natural plant feed raw material compound for improving disease resistance of laying hens as claimed in any one of claims 1 to 4, wherein the natural plant feed raw material compound comprises the following components: respectively crushing all the raw materials and then uniformly mixing or firstly uniformly mixing and then crushing together to prepare the natural plant feed raw material compound for feeding.
6. The method of claim 5, wherein: pulverizing to powder, and sieving with 60-120 mesh sieve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910502363.8A CN110179009B (en) | 2019-06-11 | 2019-06-11 | Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910502363.8A CN110179009B (en) | 2019-06-11 | 2019-06-11 | Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110179009A CN110179009A (en) | 2019-08-30 |
| CN110179009B true CN110179009B (en) | 2022-06-07 |
Family
ID=67721243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910502363.8A Active CN110179009B (en) | 2019-06-11 | 2019-06-11 | Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110179009B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114468141A (en) * | 2022-01-10 | 2022-05-13 | 安徽中医药大学 | Polysaccharide feed additive extracted from fibrous root of rhizoma anemarrhenae and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879813A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | An anti-virus Chinese medicinal composition for birds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961447B (en) * | 2012-11-08 | 2014-10-22 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for promoting egg laying performance of laying hen in middle and later periods and preparation method thereof |
| CN102972646B (en) * | 2012-11-29 | 2014-02-12 | 安徽惠尔普生物科技发展有限责任公司 | Production method and feed for health-care Chinese herbal medicine eggs |
| CN103947875B (en) * | 2014-04-15 | 2016-06-08 | 河南师范大学 | A kind of Chinese medicine feed additive and application thereof |
-
2019
- 2019-06-11 CN CN201910502363.8A patent/CN110179009B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879813A (en) * | 2006-05-16 | 2006-12-20 | 天津生机集团有限公司 | An anti-virus Chinese medicinal composition for birds |
Non-Patent Citations (2)
| Title |
|---|
| 刘再池等.活血化瘀法治疗鸡腺胃型支气管炎.《中兽医学杂志》.2000,(第04期), * |
| 谢仲权.抗菌促生长中草药饲料添加剂.《饲料与畜牧》.1995,(第01期), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110179009A (en) | 2019-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101869220B (en) | Traditional herbal medicine feed addictive for preventing and controlling swine high fever syndrome | |
| CN104161187B (en) | A kind of poultry Chinese herbal feed additive, preparation method and application | |
| CN101066313A (en) | Chinese medicine prepn for antagonizing bacteria and viruses of pig and improving pork quality and its prepn process | |
| CN106172226A (en) | A kind of cultural method of Gallus Domesticus | |
| CN109527260B (en) | Compound bioactive feed additive for poultry and preparation method thereof | |
| CN106819559A (en) | A kind of new chicken feed | |
| CN102258141B (en) | Portulaca poultry feed additive and production method thereof | |
| CN104208393B (en) | It is a kind of to be used to prevent Chinese medicine composition of infectious bronchitis of chicken and preparation method thereof | |
| CN110179009B (en) | Natural plant feed raw material compound for improving disease resistance of laying hens and preparation method thereof | |
| CN102885901A (en) | Traditional Chinese medicine composition for preventing and treating black gill disease of fishes | |
| CN104161853B (en) | A kind of Chinese medicine composition for treating poultry hepatitis and preparation method thereof | |
| CN105748734A (en) | Pure traditional Chinese medicine powder for preventing and treating pullorum disease and preparation method thereof | |
| CN105395674B (en) | A kind of Traditional Chinese medicine probiotic compound formulation and preparation method thereof for preventing and treating fowl gland ventriculitis | |
| CN105833075A (en) | Traditional Chinese medicine preparation for preventing rabbit haemorrhagic diseases | |
| CN108464406A (en) | The broiler fodder and preparation method thereof for promoting growth of meat chicken, improving meat flavor | |
| CN114468186A (en) | Barbus capito breeding fish feed and application thereof in artificial cultivation of Barbus capito | |
| CN104161986A (en) | Traditional Chinese medicine composition for preventing and treating avian influenza and its preparation method and use | |
| CN104161817B (en) | A kind of compound traditional Chinese medicine composite for preventing and treating chicken bacterial disease and preparation method thereof | |
| CN111544559A (en) | Traditional Chinese medicine preparation for preventing and treating sheep transport stress syndrome and preparation method thereof | |
| CN102894200A (en) | Foodstuff additive used for enhancing sheep antibiosis and anti-virus, and preparation method thereof | |
| CN111068000A (en) | Chinese herbal medicine feed additive for broiler chickens, and preparation method and application thereof | |
| CN104208168B (en) | A kind of for compound traditional Chinese medicine composite treating poultry respiratory infection and preparation method thereof | |
| CN109432287A (en) | A kind of traditional Chinese medicine oral liquid and preparation method thereof of prevention and treatment poultry excessive heat in the system card | |
| CN108552432A (en) | A kind of egg feedstuff and preparation method thereof improving laying rate of laying hen | |
| CN116211961B (en) | Composition for preventing and treating rumen acidosis of ruminant animals, oral preparation containing composition, preparation method and using method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: No. 9, Yugang Road, Airport Economic Comprehensive Experimental Zone, Zhengzhou City, Henan Province, 451162 Patentee after: Henan Muxiang Biotechnology Co.,Ltd. Country or region after: China Address before: 451162 airport road five, Zhengzhou, Henan Patentee before: HENAN SOAR VETERINARY PHARMACEUTICAL Co.,Ltd. Country or region before: China Patentee before: HENAN MUXIANG BIOTECHNOLOGY Co.,Ltd. |
|
| CP03 | Change of name, title or address |