CN110141608A - A kind of preparation method of anaesthetic composition and its pill that treating thyroid disease - Google Patents
A kind of preparation method of anaesthetic composition and its pill that treating thyroid disease Download PDFInfo
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- CN110141608A CN110141608A CN201910545631.4A CN201910545631A CN110141608A CN 110141608 A CN110141608 A CN 110141608A CN 201910545631 A CN201910545631 A CN 201910545631A CN 110141608 A CN110141608 A CN 110141608A
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- 230000003444 anaesthetic effect Effects 0.000 title claims abstract description 36
- 208000024799 Thyroid disease Diseases 0.000 title claims abstract description 28
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- 208000021510 thyroid gland disease Diseases 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
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- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention provides a kind of anaesthetic compositions for treating thyroid disease, it is made of deer horn, Prunella vulgaris, shellfish tooth ash, sea-buckthorn, root of kirilow rhodiola, monkshood, Radix Isatidis, Da Wuli rough gentian, corydalis and kaladana, additionally provide preparation method, by each material processing, sterilizing, mixing, be crushed, stir, be sieved to obtain medicinal powder, then it gradually sprays purified water and medicinal powder is added, bulky grain is made, purified water is gradually sprayed after screening and pellet is made in addition medicinal powder, screening, drying obtain anaesthetic pill.Anaesthetic pill of the invention is mild-natured, to break ruffian good recipe, with dry " Xi Wu element " and dry purulence blood medicine deer horn, shellfish tooth ash, Prunella vulgaris, kaladana and kill based on " glutinous " medicine monkshood, sea-buckthorn is equipped with as solution silt disease, dilute blood, the blue root of root of kirilow rhodiola, Da Wuli rough gentian and hundred is with antipyretic, and corydalis is with clear latent heat, detumescence.It is mainly used for Thyroid Gland Swell, tubercle, Cystic thyroid nodule, thyroid adenoma and broken ruffian, pill is made convenient for taking and carrying.
Description
Technical field
The invention belongs to anaesthetic technical fields, and in particular to a kind of anaesthetic composition and its pill for treating thyroid disease
Preparation method.
Background technique
Thyroid disease belongs to the scope of Chinese medicine " goiter ", with people's operating pressure, eating habit and life style
Change, more and more people start with thyroid disease.The cause of disease of thyroid disease is mainly feelings will internal injury, diet and water
Native inappropriate and congenital sexual factor etc..Long-term angry or pondering over reaches irritability mistake in tune, body fluid cannot reform and be condensed into phlegm, the stagnation of the circulation of vital energy
Phlegm is solidifying, stasis throat, forms goiter；Diet is unhealthy or not acclimatized will affect spleen and stomach function, the dysfunction of the spleen in transport, the operation of qi and blood
Imbalance gathers temperature into phlegm, and the poly- throat of mental disorder stasis is then sent out as goitre；If there is thyroid disease medical history in family, offspring's disease incidence compared with
It is high.
Most of thyroid disease, such as Thyroid Gland Swell, tubercle, Cystic thyroid nodule, thyroid adenoma and broken ruffian are equal
For benign lesion, western medical treatment thyroid disease uses the drug therapies such as thyroxine mostly, but recurrence rate is higher, and curative effect owes steady
Fixed, Long-term Oral thyroxine is easy to cause a variety of side effects and adverse reaction；Surgical resection therapy easily cause again it is temporary or
Permanent hypothyroidism, is not received usually by patient.
Summary of the invention
Technical problem to be solved by the present invention lies in, provide a kind of to treat thyroid gland in view of the above shortcomings of the prior art
The anaesthetic composition of the anaesthetic composition of disease and its preparation method of pill, the treatment thyroid disease is mild-natured, good for broken ruffian
Side with dry " Xi Wu element " and dry purulence blood medicine deer horn, shellfish tooth ash, Prunella vulgaris, kaladana and kills based on " glutinous " medicine monkshood, is equipped with sand
Spine is solution silt disease, dilute blood, and the blue root of root of kirilow rhodiola, Da Wuli rough gentian and hundred is with antipyretic, and corydalis is with clear latent heat, detumescence.It is main to use
Thyreoidine enlargement, tubercle, Cystic thyroid nodule, thyroid adenoma and broken ruffian are made pill and are convenient for taking and carrying, the present invention
Treatment thyroid disease anaesthetic composition it is without side-effects, curative effect is preferable.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of anaesthetic group for treating thyroid disease
Object is closed, is made of raw material from the following weight: 3 parts of deer horn, 2.4 parts of Prunella vulgaris, shellfish tooth grey 2.4 parts, 2.4 parts of sea-buckthorn, root of kirilow rhodiola
2.4 parts, 2.4 parts of monkshood, 2.4 parts of Radix Isatidis, 2.4 parts of Da Wuli rough gentian, 2.4 parts of corydalis and 2.4 parts of kaladana.
Deer horn: it is sweet in flavor, salty, it is warm-natured.Energy kidney-replenishing, promoting circulation of blood, detumescence, promoting blood circulation to remove blood stasis.
Prunella vulgaris: heat-clearing, dissipating bind, detumescence the effect of.
Shellfish tooth ash: acrid flavour, hardship, warm-natured, effect is broken ruffian, and dry Xieri Wusu Symptom stops blooding and moves back screen.
Sea-buckthorn: cough-relieving apophlegmatic, relieving dyspepsia, promoting blood circulation to remove blood stasis.For coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, falls and flutter the stasis of blood
Swollen, blood stasis closed.
Root of kirilow rhodiola: cold, sweet, puckery, lung channel has the effect of tonifying Qi clearing lung-heat, intelligence development nourishing heart, controlling of bleeding with astringents, eliminating stasis to subdue swelling.It cures mainly
Deficiency of vital energy and physically weak, after being ill chilly, shortness of breath and fatigue, cough with lung heat, hemoptysis, leukorrhea diarrhea, traumatic injury etc..
Monkshood: pungent, bitter, heat;It is very toxic.Return heart, liver,kidney,spleen warp.Dispelling wind and eliminating dampness, antalgic.
Radix Isatidis: return heart stomach meridian has the effect of clearing heat and detoxicating, cool blood relieving sore-throat.
Da Wuli rough gentian: chest is removed in energy wind-damp dispelling, reducing the asthenic fever, analgesic, clearing lung-heat, cough-relieving, removing toxic substances, treatment " hair disease ", carbuncle, furuncle
Portion's fire.
Corydalis: clearing heat and detoxicating, antipruritic, convergence, controlling nocturnal emission with astringent drugs, moistening lung, cough-relieving.
Kaladana: drink is washed in water pouring defaecation, dissolving phlegm, and desinsection attacks product.For edema swelling, constipation and anuresis, phlegm retention accumulation, the circulation of vital energy in the wrong direction
It breathes with cough, abdominal pain due to enterositosis, roundworm disease, taeniasis.
The present invention also provides the method for the anaesthetic composition pill of above-mentioned treatment thyroid disease, this method include with
Lower step:
Step 1: by deer horn, Prunella vulgaris, shellfish tooth ash, sea-buckthorn, root of kirilow rhodiola, monkshood, Radix Isatidis, Da Wuli rough gentian, corydalis and leading a cow
Son successively processed respectively, sterilize after mix, be put into boulder crusher be crushed 25min ~ 30min, obtain coarse powder；
It is crushed 25min ~ 30min Step 2: coarse powder obtained in step 1 is put into cracker for medicine, is then placed in slot
3h is stirred in formula mixing machine, then after standing 40min, cross the sieve of 100 mesh, obtain medicinal powder；
Step 3: medicinal powder a obtained in the step of part two is sprinkled into coating pan, purified water a is uniformly sprayed in coating pan,
Machinery rotation or artificial rubbing are by after medicinal powder a wetting, then carry out mechanical rotation or artificial rubbing, obtain little particle, then to sugar-coat
The medicinal powder b of part is added again in pot, and uniformly sprays purified water b to little particle, carries out mechanical rotation or artificial rubbing for medicine
Powder b is wrapped in short grained outside, operates repeatedly, obtains bulky grain, when bulky grain is granule rice size, screens uniform in size
Bulky grain obtain ball mould；
Step 4: ball mould obtained in step 3 is poured into coating pan, sprinkling purified water c is added after the wetting uniformly of ball mould
Medicinal powder c, is wrapped in the outside of ball mould, operated repeatedly by part medicinal powder c, obtains pellet, and the pellet that screening diameter is 5mm obtains
Pill；
Step 5: pill obtained in step 4 is dried under conditions of temperature is 60 DEG C, every 2h turns over down disk 1 time, obtains
Anaesthetic pill；The water content of the anaesthetic pill is 3%~6%.
Preferably, the stirring rate of trough-type mixture machine described in step 2 is 500r/min ~ 800r/min.
Preferably, the revolving speed of institute's coating pan is 250r/min ~ 300r/min in step 2 and step 3.
Preferably, the mass ratio of medicinal powder a and purified water a, medicinal powder b and purified water b described in step 3 are 1:2.
Preferably, the mass ratio of medicinal powder c described in step 4 and purified water c are 1:2.
Compared with the prior art, the present invention has the following advantages:
The anaesthetic composition for the treatment of thyroid disease of the invention is mild-natured, to break ruffian good recipe, with dry " Xi Wu element " and dry purulence blood
It medicine deer horn, shellfish tooth ash, Prunella vulgaris, kaladana and kills based on " glutinous " medicine monkshood, is equipped with sea-buckthorn as solution silt disease, dilute blood, red scape
It, Da Wuli rough gentian and hundred blue roots with antipyretic, corydalis is with clear latent heat, detumescence.It is mainly used for Thyroid Gland Swell, tubercle, thyroid gland
Capsule tubercle, thyroid adenoma and broken ruffian are made pill and are convenient for taking and carrying, the anaesthetic group for the treatment of thyroid disease of the invention
Conjunction object is without side-effects, and curative effect is preferable.
The anaesthetic composition for treating thyroid disease is prepared into pill, because containing monkshood in ingredient, to human oral cavity
It stimulates larger, is prepared into that pill is easy to carry, is easy to take, reduces the bitter mouthfeel during taking, it is non-stimulated to oral cavity, and
Pill has sustained release process in stomach, makes lasting medicine, preparation method of the invention by each material processing, sterilizing, mixing, it is broken,
Stirring, sieving obtain medicinal powder, then gradually spray purified water and medicinal powder is added, bulky grain is made, pours into coating pan after screening,
Gradually pellet is made in sprinkling purified water and addition medicinal powder, and drying obtains anaesthetic pill after screening, and the anaesthetic pill of preparation is enough preferable
Reservation raw material drug effect, exquisite in texture is uniform in size.
Specific embodiment
Embodiment 1
The anaesthetic composition of the treatment thyroid disease of the present embodiment, is made of raw material from the following weight: by following parts by weight
Raw material be made: 3 parts of deer horn, 2.4 parts of Prunella vulgaris, shellfish tooth grey 2.4 parts, 2.4 parts of sea-buckthorn, 2.4 parts of root of kirilow rhodiola, 2.4 parts of monkshood, plate
2.4 parts of blue root, 2.4 parts of Da Wuli rough gentian, 2.4 parts of corydalis and 2.4 parts of kaladana.
The present embodiment additionally provides the method for the anaesthetic composition pill of above-mentioned treatment thyroid disease, and this method includes
Following steps:
Step 1: by deer horn, Prunella vulgaris, shellfish tooth ash, sea-buckthorn, root of kirilow rhodiola, monkshood, Radix Isatidis, Da Wuli rough gentian, corydalis and leading a cow
Son successively processed respectively, sterilize after mix, be put into boulder crusher be crushed 30min, obtain coarse powder；
It is crushed 30min Step 2: coarse powder obtained in step 1 is put into cracker for medicine, is then placed in slot type mixing
3h is stirred in machine, then after standing 30min, cross the sieve of 100 mesh, obtain medicinal powder；The stirring rate of the trough-type mixture machine is 800r/
min；
Step 3: medicinal powder a obtained in the step of part two is sprinkled into the coating pan that revolving speed is 300r/min, in coating pan
Purified water a is uniformly sprayed, after machinery rotation or artificial rubbing soak medicinal powder a, then mechanical rotation or artificial rubbing is carried out, obtains
Little particle, then the medicinal powder b of part is added into coating pan again, and purified water b is uniformly sprayed to little particle, carry out mechanical rotation
Or medicinal powder b is wrapped in short grained outside by artificial rubbing, is operated repeatedly, is obtained bulky grain, when bulky grain is granule rice size
When, it screens bulky grain of uniform size and obtains ball mould；The mass ratio of the medicinal powder a and purified water a, medicinal powder b and purified water b is
1:2；
Step 4: ball mould obtained in step 3 is poured into the coating pan that revolving speed is 300r/min, purified water c is sprayed by ball mould
After wetting uniformly, part medicinal powder c is added, medicinal powder c is wrapped in the outside of ball mould, is operated repeatedly, obtain pellet, screening diameter is
The pellet of 5mm, obtains pill；The mass ratio of the medicinal powder c and purified water c is 1:2；
Step 5: pill obtained in step 4 is dried under conditions of temperature is 70 DEG C, every 2h turns over down disk 1 time, obtains
Anaesthetic pill；The water content of the anaesthetic pill is 3%.
Patient so-and-so, female, 35 years old, Inner Mongol herdsman, the past Hypothyroidism medical history 1 year, patient's throat usually
Portion's foreign body sensation, out of strength, depressed, dry skin, the medical our hospital of the symptoms such as tinnitus show by auxiliary examination: first function five: its
Middle TSH (thyrotropic hormone): 22.420uIU/mL；TPOAb (anti-thyroid peroxidase antibody): > 600IU/mL,
His index is normal；Thyroid gland color ultrasound is shown: thyroid gland diffusivity lesion；Physical examination: thyroid gland matter is soft, there is tenderness, does not hear and blood vessel is miscellaneous
Sound, double pulmonary respiration sounds are clear, do not hear and dry and wet rale, and heart circle is normal, heart sound can, 78 beats/min of heart rate, abdomen is flat, soft, double lower limb
Without oedema, pulse condition: empty, micro- and weak, tongue picture: tongue is red, whitish tongue is thick；Diagnosis: Hypothyroidism；To break ruffian, silt disease is solved, clearly
Latent heat etc. is that principle of reatment gives morning: the anaesthetic composition pill 3g for the treatment of thyroid disease manufactured in the present embodiment is after meal
30min taken with boiled water；Evening: the anaesthetic composition pill 3g for the treatment of thyroid disease manufactured in the present embodiment after meal 30min with opening
Water takes, and patient's bottleneck throat foreign body sensation, out of strength after 3 months oral drug therapies, and depressed etc. the symptoms were significantly improved, multiple
Cha Jiagong five: TSH (thyrotropic hormone): 13.380uIU/mL, other indexs are normal.
Patient so-and-so, female, 44 years old, Inner Mongol herdsman, the past thyroid nodule medical history 1 year, patient's bottleneck throat foreign matter usually
Sense, the medical our hospital of the symptoms such as irritability, hidrosis, abdominal distension, facial area edema, out of strength show by auxiliary examination: thyroid gland color ultrasound is shown:
Thyroid gland diffusivity lesion；Right lobe of thyroid gland solid nodules-suggestion close observation；Physical examination: thyroid gland matter is soft, has tenderness, not
Hear and vascular murmur, double pulmonary respiration sounds are clear, do not hear and dry and wet rale, and heart circle is normal, heart sound can, 80 beats/min of heart rate, abdomen is flat,
Soft, double lower limb is without oedema, pulse condition: number, string and tight, tongue picture: tongue is red, yellow tongue fur；Diagnosis: thyroid gland function tubercle；To break ruffian, solution is become silted up
Disease, clear latent heat etc. be principle of reatment give morning: it is manufactured in the present embodiment treatment thyroid disease anaesthetic composition pill 3g in
30min taken with boiled water after meal；Evening: the anaesthetic composition pill 3g 30min after meal for the treatment of thyroid disease manufactured in the present embodiment
With taken with boiled water, the symptoms such as patient's bottleneck throat foreign body sensation, facial area edema, out of strength are obviously good after 20 days oral drug therapies
Turn, check thyroid gland color ultrasound is shown: thyroid gland diffusivity lesion, without obvious tubercle.
The anaesthetic composition of the treatment thyroid disease of the present embodiment is mild-natured, to break ruffian good recipe, with dry " Xi Wu element " and
It dry purulence blood medicine deer horn, shellfish tooth ash, Prunella vulgaris, kaladana and kills based on " glutinous " medicine monkshood, is equipped with sea-buckthorn as solution silt disease, diluted blood
Liquid, the blue root of root of kirilow rhodiola, Da Wuli rough gentian and hundred is with antipyretic, and corydalis is with clear latent heat, detumescence.It is mainly used for Thyroid Gland Swell, tubercle,
Cystic thyroid nodule, thyroid adenoma and broken ruffian are made pill and are convenient for taking and carrying, the treatment thyroid disease of the present embodiment
Anaesthetic composition it is without side-effects, curative effect is preferable.
The anaesthetic composition for treating thyroid disease is prepared into pill, because containing monkshood in ingredient, to human oral cavity
It stimulates larger, is prepared into that pill is easy to carry, is easy to take, reduces the bitter mouthfeel during taking, it is non-stimulated to oral cavity, and
Pill has sustained release process in stomach, makes lasting medicine, preparation method of the invention by each material processing, sterilizing, mixing, it is broken,
Stirring, sieving obtain medicinal powder, then gradually spray purified water and medicinal powder is added, bulky grain is made, pours into coating pan after screening,
Gradually pellet is made in sprinkling purified water and addition medicinal powder, and drying obtains anaesthetic pill after screening, and the anaesthetic pill of preparation is enough preferable
Reservation raw material drug effect, exquisite in texture is uniform in size.
The above is only presently preferred embodiments of the present invention, is not intended to limit the invention in any way.It is all according to invention skill
Art any simple modification, change and equivalence change substantially to the above embodiments, still fall within technical solution of the present invention
Protection scope in.
Claims (6)
1. a kind of anaesthetic composition for treating thyroid disease, which is characterized in that be made of raw material from the following weight: deer horn 3
Part, 2.4 parts of Prunella vulgaris, shellfish tooth grey 2.4 parts, 2.4 parts of sea-buckthorn, 2.4 parts of root of kirilow rhodiola, 2.4 parts of monkshood, 2.4 parts of Radix Isatidis, Da Wuli
2.4 parts of rough gentian, 2.4 parts of corydalis and 2.4 parts of kaladana.
2. a kind of method for the anaesthetic composition pill for preparing treatment thyroid disease as described in claim 1, feature exist
In, method includes the following steps:
Step 1: by deer horn, Prunella vulgaris, shellfish tooth ash, sea-buckthorn, root of kirilow rhodiola, monkshood, Radix Isatidis, Da Wuli rough gentian, corydalis and leading a cow
Son successively processed respectively, sterilize after mix, be put into boulder crusher be crushed 25min~30min, obtain coarse powder；
It is crushed 25min~30min Step 2: coarse powder obtained in step 1 is put into cracker for medicine, is then placed in
3h is stirred in trough-type mixture machine, then after standing 40min, cross the sieve of 100 mesh, obtain medicinal powder；
Step 3: medicinal powder a obtained in the step of part two is sprinkled into coating pan, purified water a is uniformly sprayed in coating pan,
Machinery rotation or artificial rubbing are by after medicinal powder a wetting, then carry out mechanical rotation or artificial rubbing, obtain little particle, then to sugar-coat
The medicinal powder b of part is added again in pot, and uniformly sprays purified water b to little particle, carries out mechanical rotation or artificial rubbing for medicine
Powder b is wrapped in short grained outside, operates repeatedly, obtains bulky grain, when bulky grain is granule rice size, screens uniform in size
Bulky grain obtain ball mould；
Step 4: ball mould obtained in step 3 is poured into coating pan, sprinkling purified water c is added after the wetting uniformly of ball mould
Medicinal powder c, is wrapped in the outside of ball mould, operated repeatedly by part medicinal powder c, obtains pellet, and the pellet that screening diameter is 5mm obtains
Pill；
Step 5: pill obtained in step 4 is dried under conditions of temperature is 60 DEG C, every 2h turns over down disk 1 time, obtains
Anaesthetic pill；The water content of the anaesthetic pill is 3%~6%.
3. according to the method described in claim 2, it is characterized in that, the stirring rate of trough-type mixture machine described in step 2 is
500r/min~800r/min.
4. according to the method described in claim 2, it is characterized in that, the revolving speed of institute's coating pan is in step 2 and step 3
250r/min~300r/min.
5. according to the method described in claim 2, it is characterized in that, medicinal powder a and purified water a described in step 3, medicinal powder b and purifying
The mass ratio of water b is 1:2.
6. according to the method described in claim 2, it is characterized in that, the mass ratio of medicinal powder c described in step 4 and purified water c are
1:2.
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| CN114522193A (en) * | 2022-01-01 | 2022-05-24 | 锡林其其格 | Mongolian medicine composition for treating thyromegaly, preparation method and quality control method |
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| CN101007085A (en) * | 2006-11-16 | 2007-08-01 | 内蒙古复旦蒙耀生物技术有限责任公司 | A drug for treating hyperthyroidism and its preparation method |
| CN104510892A (en) * | 2014-12-23 | 2015-04-15 | 青岛市城阳区人民医院 | Traditional Chinese medicinal formula for treating thyroid tumor |
| US20180055898A1 (en) * | 2016-08-29 | 2018-03-01 | Tianfeng Jiang | Traditional chinese medicine composition for preventing and treating externally diabetes and a method of using the same |
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| CN101007085A (en) * | 2006-11-16 | 2007-08-01 | 内蒙古复旦蒙耀生物技术有限责任公司 | A drug for treating hyperthyroidism and its preparation method |
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Cited By (2)
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| CN114522193A (en) * | 2022-01-01 | 2022-05-24 | 锡林其其格 | Mongolian medicine composition for treating thyromegaly, preparation method and quality control method |
| CN114522193B (en) * | 2022-01-01 | 2024-04-12 | 锡林其其格 | Mongolian medicine composition for treating thyromegaly, preparation method and quality control method |
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