CN110123732A - One kind containing fibronectin cosmetic material preparation method - Google Patents
One kind containing fibronectin cosmetic material preparation method Download PDFInfo
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- CN110123732A CN110123732A CN201910267113.0A CN201910267113A CN110123732A CN 110123732 A CN110123732 A CN 110123732A CN 201910267113 A CN201910267113 A CN 201910267113A CN 110123732 A CN110123732 A CN 110123732A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The disclosure of the invention of this composite skin care product preparation technical field is a kind of to contain fibronectin cosmetic material preparation method, by weight should include: fibronectin containing fibronectin cosmetic material composition: 0.1-3 parts；Desert rose (ADENIUM OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolysis silk: 0.1-1 parts；Rose (ROSA RUGOSA) flower extract: 0.1-1 parts；Water: 5 parts, the present invention repairs fibroblast, and fibroblast is promoted to generate the various nutritional ingredients of collagen, elastin, hyaluronic acid, eradicates wrinkle, restores elasticity of skin comprehensively.Melanocyte is repaired, inhibits the activity of various enzymes in melanocyte, reduces the secretion of melanin；Transfer the melanin that phagocyte removes abnormal accumulation in skin; repair allergic skin: fibronectin is a kind of multifunctional protein, can effectively repair impaired skin, have effects that multi-biological; so that skin metabolic function is restored normal, is finally reached the purpose for repairing allergy skin.
Description
Technical field
The present invention relates to skin care fields, more particularly to one kind to contain fibronectin cosmetic material preparation method.
Background technique
Skin care item are many kinds of on the market at present, and effect is different, including whitening, moisturizing, nti-freckle and anti-aging etc..But it is very much
Product is more or less added to some chemical substances being harmful to the human body, although these substances have short-term beauty to the skin of people
The skin care effects such as white, anti-aging can make skin severely damaged, long acne, color spot and oil occur instead but if being used for a long time
Rouge dyssecretosis etc.；Fibronectin, Fibronectin are to be present in tissue and a kind of intracellular multifunctional protein,
It is the glycoprotein of macromolecule, high activity, is made of two similar subunits, be connected in C-terminal by disulfide bond, entire molecule is in V
Shape, molecular weight is in 440-450KDa.There are six functional areas and a RGD sequences for each subunit of fibronectin, can combine liver
The many kinds of substance such as element, collagen, fiber, cell and 11 kinds of integrins, wound repair, cancer diagnosis, in terms of send out
Important function is waved, national Bureau of Drugs Supervision's cosmetics supervision department has delivered in cosmetics supervision and management frequently asked questions and corresponding answer 20190110
It has been mentioned to oligopeptides -1 and people's oligopeptides 1 (epidermal growth factor, EGF) non-same substance.Oligopeptides -1 is glycine, histidine
The synthetic peptide formed with 3 kinds of amino acid such as lysines, and people's oligopeptides -1 also known as epidermal growth factor (Epidermal Growth
Factor, EGF), " 53 peptide " being made of 53 amino acid, molecular weight is 6200 dalton units.Oligopeptides -1 is embodied in me
State's " having used cosmetic material Names Catalogue " (version in 2015) uses generally as skin conditioning agent.And people's oligopeptides -1 not by
It is embodied in the catalogue, generally in medical domain using more, clinical indication is that external curing burn, wound and surgical wound are cured
It closes, accelerates the epidermal growth of transplanting.Since molecular weight is larger, EGF is more difficult under the conditions of normal skin barrier to be absorbed, once skin
Skin barrier function is not complete, may cause other potential safety issues.In terms of effectiveness and reliability, EGF
It must not be used as cosmetic material.To sum up, it is different from oligopeptides -1, people's oligopeptides -1 (EGF) must not make as cosmetic material
With.Addition or product declare oligopeptides containing someone -1 or EGF in formula, belong to illegal product.In view of EGF discomfort
It shares in making an addition to cosmetics, therefore, we have proposed one kind to contain fibronectin cosmetic material preparation method.
Summary of the invention
The purpose of the present invention is to solve disadvantages existing in the prior art, and the one kind proposed contains fibronectin
Cosmetic method for preparing raw material.
To achieve the goals above, present invention employs following technical solutions: one kind containing fibronectin cosmetic material
Preparation method, should contain fibronectin cosmetic material composition include: by weight
Preferably, described a kind of containing fibronectin cosmetic material preparation method, it should be former containing fibronectin cosmetics
The preparation method of material includes the following steps:
S1: raw material: fibronectin: 0.1-3 parts raw material screening: with by the parts by weight of composition in claim 1；
Desert rose (ADENIUM OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolysis silk: 0.1-1 parts；Rose (ROSA
RUGOSA) flower extract: 0.1-1 parts；Water: 5 parts；
S2: it stirs for the first time: the fibronectin that will be chosen in step S1: 0.1-3 parts；Desert rose (ADENIUM
OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolyze silk: 0.1-1 parts stir in ultrasonic oscillator, so
After pour the mixture into homogeneous 5 minutes in homogenizer, it is spare to obtain mixture；
S3: second stirs: rose (ROSA RUGOSA) flower will be added again in the resulting mixture of above-mentioned steps S1 and mention
Take object: 0.1-1 parts；Water:, stirring in ultrasonic oscillator by 5 parts, heating, and band temperature obtains after being down to 40 DEG C
Composition finished product.
Preferably, homogenizer model RX-200l in the step S2.
Preferably, the facial mask essence that composition finished product obtained is once added in skin care item at 40 DEG C in the step S3
In liquid, Essence, lotion and cream.
It is provided by the invention a kind of containing fibronectin cosmetic material preparation method, reparation fibroblast, and promote
Fibroblast generates the various nutritional ingredients of collagen, elastin, hyaluronic acid, eradicates wrinkle, restores skin comprehensively
Elasticity.Melanocyte is repaired, inhibits the activity of various enzymes in melanocyte, reduces the secretion of melanin；It is thin to transfer phagocytosis
Born of the same parents remove the melanin of abnormal accumulation in skin, and repair allergic skin: fibronectin is a kind of multifunctional protein, can effectively be repaired
Impaired skin, has effects that multi-biological, so that skin metabolic function is restored normal, is finally reached the mesh for repairing allergy skin
, and present invention can apply in skin care item facial mask essence, Essence, lotion and cream maintenance skin effect object
Addition, and protect product stability.
Detailed description of the invention
Fig. 1 is preparation flow figure of the present invention；
Fig. 2 is each group wounds in mice healing time of the present invention and decrustation time to compare figure
Fig. 3 is that each group mouse burned skin pathomorphism of the present invention compares figure.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
One kind containing fibronectin cosmetic material preparation method, should be containing fibronectin cosmetic material composition by weight
Measuring part includes:
The preparation method for containing fibronectin cosmetic material includes the following steps:
S1: raw material: fibronectin: 0.1-3 parts raw material screening: with by the parts by weight of composition in claim 1；
Desert rose (ADENIUM OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolysis silk: 0.1-1 parts；Rose (ROSA
RUGOSA) flower extract: 0.1-1 parts；Water: 5 parts；
S2: it stirs for the first time: the fibronectin that will be chosen in step S1: 0.1-3 parts；Desert rose (ADENIUM
OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolyze silk: 0.1-1 parts stir in ultrasonic oscillator, so
After pour the mixture into homogeneous 5 minutes in homogenizer, it is spare to obtain mixture；
S3: second stirs: rose (ROSA RUGOSA) flower will be added again in the resulting mixture of above-mentioned steps S1 and mention
Take object: 0.1-1 parts；Water:, stirring in ultrasonic oscillator by 5 parts, heating, and band temperature obtains after being down to 40 DEG C
Composition finished product.
Wherein, homogenizer model RX-200l in the step S2；Composition finished product obtained is 40 in the step S3
It DEG C is once added in the facial mask essence in skin care item, Essence, lotion and cream.
Connect according to fig. 2 with Fig. 3, reference preclinical medicine and 2013, Vol.33Issue of clinic (7): 873-875 pig blood fiber
Connect the documents and materials that albumen promotes III degree of burn-healing of mouse.
Study under same concentrations different purity fibronectin (FN) to the effect of III degree of burn wound healing of mouse and
Difference.Method prepares III degree of bum model of back of mice, and model mice divides 5 groups at random: fibronectin high-purity group
(85%), moderate purity group (75%), low-purity group (65%), bFGF-ESSEX positive controls and blank control group observe each group
Wound healing time, decrustation time and Pathologic changes.As a result the fibronectin of different purity is compared with blank control group
It can be shortened the time and decrustation time of mouse skin wound healing, and the pathomorphism of surface of a wound skin can be significantly improved.Conclusion
Fibronectin remarkably promotes effect to III degree of burn-healing of mouse, and moderate purity group may have potential using value.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (4)
1. one kind contains fibronectin cosmetic material preparation method, it is characterised in that: fibronectin cosmetic material should be contained
Composition includes: by weight
2. a kind of contain fibronectin cosmetic material preparation method as described in claim 1, it is characterised in that: fibre should be contained
Even the preparation method of albumen cosmetic material includes the following steps:
S1: raw material: fibronectin: 0.1-3 parts raw material screening: with by the parts by weight of composition in claim 1；Desert
Rose (ADENIUM OBESUM) leaf cell extract: 0.1-0.5 parts；Hydrolysis silk: 0.1-1 parts；Rose (ROSA RUGOSA)
Flower extract: 0.1-1 parts；Water: 5 parts；
S2: it stirs for the first time: the fibronectin that will be chosen in step S1: 0.1-3 parts；Desert rose (ADENIUM OBESUM) leaf
Cell extract: 0.1-0.5 parts；Hydrolyze silk: 0.1-1 parts stir in ultrasonic oscillator, then will mixing
Object pours into homogeneous 5 minutes in homogenizer, and it is spare to obtain mixture；
S3: second stirs: rose (ROSA RUGOSA) flower will be added again in the resulting mixture of above-mentioned steps S1 and extract
Object: 0.1-1 parts；Water:, stirring in ultrasonic oscillator by 5 parts, heating, and band temperature obtains group after being down to 40 DEG C
Close object finished product.
3. one kind according to claim 2 contains fibronectin cosmetic material preparation method, it is characterised in that: the step
Homogenizer model RX-200l in rapid S2.
4. one kind according to claim 2 contains fibronectin cosmetic material preparation method, it is characterised in that: the step
Composition finished product obtained is in 40 DEG C of facial mask essences being once added in skin care item, Essence, lotion and cream in rapid S3
In.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910267113.0A CN110123732A (en) | 2019-04-03 | 2019-04-03 | One kind containing fibronectin cosmetic material preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910267113.0A CN110123732A (en) | 2019-04-03 | 2019-04-03 | One kind containing fibronectin cosmetic material preparation method |
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| CN110123732A true CN110123732A (en) | 2019-08-16 |
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| CN201910267113.0A Pending CN110123732A (en) | 2019-04-03 | 2019-04-03 | One kind containing fibronectin cosmetic material preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623851A (en) * | 2019-10-18 | 2019-12-31 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN110755281A (en) * | 2019-11-16 | 2020-02-07 | 许帅辉 | Skin repairing and nursing composition and preparation method thereof |
| CN112022731A (en) * | 2020-08-31 | 2020-12-04 | 广州丽彦妆生物科技有限公司 | Production process of full-effect repair cream |
| CN116531306A (en) * | 2023-02-27 | 2023-08-04 | 珠海盈盛联科生物科技有限公司 | Composition containing recombinant human fibronectin and having repairing effect, preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102725308A (en) * | 2009-11-30 | 2012-10-10 | 昆士兰技术大学 | Fibronectin: growth factor chimeras |
| CN108794639A (en) * | 2018-07-03 | 2018-11-13 | 广州澳特朗生物技术有限公司 | A kind of recombination fibronectin and its application |
| CN109528610A (en) * | 2018-12-21 | 2019-03-29 | 广州科恩生物技术有限公司 | One kind repairing Essence and preparation method thereof based on private gene customization |
-
2019
- 2019-04-03 CN CN201910267113.0A patent/CN110123732A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102725308A (en) * | 2009-11-30 | 2012-10-10 | 昆士兰技术大学 | Fibronectin: growth factor chimeras |
| CN108794639A (en) * | 2018-07-03 | 2018-11-13 | 广州澳特朗生物技术有限公司 | A kind of recombination fibronectin and its application |
| CN109528610A (en) * | 2018-12-21 | 2019-03-29 | 广州科恩生物技术有限公司 | One kind repairing Essence and preparation method thereof based on private gene customization |
Non-Patent Citations (3)
| Title |
|---|
| 乔琳: "《最美中国方》", 31 December 2011, 福建科学技术出版社 * |
| 化妆品报: "《https://mp.weixin.qq.com/s/BtvfA-nafTYO-DNKeFtjnw》", 1 June 2018, 微信公众号 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110623851A (en) * | 2019-10-18 | 2019-12-31 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN110623851B (en) * | 2019-10-18 | 2022-04-29 | 广州市千邦化妆品有限公司 | Soothing and repairing essence and preparation method thereof |
| CN110755281A (en) * | 2019-11-16 | 2020-02-07 | 许帅辉 | Skin repairing and nursing composition and preparation method thereof |
| CN112022731A (en) * | 2020-08-31 | 2020-12-04 | 广州丽彦妆生物科技有限公司 | Production process of full-effect repair cream |
| CN116531306A (en) * | 2023-02-27 | 2023-08-04 | 珠海盈盛联科生物科技有限公司 | Composition containing recombinant human fibronectin and having repairing effect, preparation method and application |
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Application publication date: 20190816 |