CN110123320A - A kind of portable frequency sweep impedance bioelectrical measurement system and its measurement method - Google Patents
A kind of portable frequency sweep impedance bioelectrical measurement system and its measurement method Download PDFInfo
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- CN110123320A CN110123320A CN201910393748.5A CN201910393748A CN110123320A CN 110123320 A CN110123320 A CN 110123320A CN 201910393748 A CN201910393748 A CN 201910393748A CN 110123320 A CN110123320 A CN 110123320A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0536—Impedance imaging, e.g. by tomography
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
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Abstract
The invention discloses a kind of low cost, high-precision portable frequency sweep impedance bioelectrical measurement system and its measurement method.Frequency sweep impedance bioelectrical measurement system in the present invention is made of PC host computer and the slave computer based on fpga chip.Fpga chip is a programmable signal processing chip, DAC module is cooperated to generate swept frequency excitation signal, it controls ADC module and double channels acquisition and in the chip portion's progress Fast Fourier Transform (FFT) (FFT) and parameter calculating is carried out to the information of voltage of peripheral circuit, result is finally transmitted into PC host computer by USB serial ports and carries out data processing.Frequency sweep impedance bioelectrical measurement system structure in the present invention is simple, on the basis of meeting frequency range and precision, greatly reduces cost and volume, and compensates for the deficiency of general portable impedance measuring equipment single-frequency measurement.
Description
Technical field:
The present invention relates to a kind of portable frequency sweep impedance bioelectrical measurement systems and its measurement method, in particular to one kind to be applied to
The portable frequency sweep impedance bioelectrical measurement system of bio-electrical impedance detection.
Background technique:
Since biological tissue cell can be equivalent to electronic component, so some functional lesions of human organ and life
The activity change of object cell can all cause the impedance spectrum property of biological tissue to change.And the capacitive character of cell membrane makes biological tissue
Frequency dependence is showed, so analyze impedance modal data, the function such as the relevant physiology of available biological tissue, pathology
It can property information.Bio-electrical impedance detection is based on electrochemical impedance spectroscopy, by the sinusoidal excitation for applying small amplitude to biological tissue
Signal can obtain the impedance modal data within the scope of tissue certain frequency, to analyze the biological nature of biological tissue.
Bio-electrical impedance detection generally requires to apply the wider pumping signal of frequency band and filter out high-frequency noise to tie measurement
The influence of fruit.Impedance analyzer is now more common bio-electrical impedance detection device, which can be in wider frequency rate model
The electrology characteristics such as the impedance of determinand are measured in enclosing.But because its volume is larger, the device is complicated, and expensive, impedance analyzer is past
It is past to be confined to the places such as laboratory, it is difficult to obtain popularization application in routine health context of detection.
And existing portable measuring device versatility is poor, is unable to satisfy the requirement of biological health detection.With
AD5933 is that the portable device of representative may be implemented continuously to measure, but its frequency range is lower, is unable to satisfy most of biology
The requirement of measurement；And some wideband measuring devices can only carry out single-frequency measurement every time, greatly reduce multifrequency measurement efficiency and
The degree of automation, and lack host computer interface, so that there is also inconvenient property in analysis subsequent to impedance spectrum processing.
Summary of the invention:
The present invention be in order to solve the above-mentioned problems of the prior art and to provide a kind of integrated level higher, there is frequency sweep to survey
Function is measured, the portable frequency sweep impedance bioelectrical measurement system and its survey of multifrequency measurement efficiency and measurement result precision can be greatly improved
Amount method.
The present invention adopts the following technical scheme: a kind of portable frequency sweep impedance bioelectrical measurement system, comprising:
PC host computer 1；
Slave computer；
System clock 2；
Peripheral circuit module 10 forms circuit under test with determinand 11；
Swept signal generator, the DDS swept-frequency signal unit 4 for being configured to FPGA inside programming cooperate DAC hardware module 8
Swept frequency excitation signal is generated, is then applied in circuit under test；
ADC acquisition and FFT module are configured to ADC acquisition module 9 and acquire determinand 11 and feedback in circuit under test respectively
Resistance R112, R213 or R3Then the information of voltage at 14 both ends carries out FFT to two-way information of voltage collected respectively；
It is configured to calculate determinand complex impedance based on the frequency domain data of two-way FFT transform parameter calculating module 16, and
Frequency sweep point based on computer control screens calculated result, finally carries out the selection result input FIFO latch (5)
It latches.
USB serial port module 3, be configured to realize slave computer and PC host computer 1 communication, transmission PC control order and
Slave computer measurement result.
Further, the peripheral circuit module 10 is the autobalance built using operational amplifier chip THS4221
Bridge circuit.
Further, the swept signal generator cooperates DAC hardware by the software module that FPGA inside programming is constituted
Module realization, the phase accumulator and frequency accumulator and store a cycle just that software module is 32 by data bit width
The wave memorizer of string wave is constituted, and hardware module is made of D/A conversion circuit and filter amplification circuit.
Further, the ADC acquisition module cooperates ADC hardware module to realize by FPGA inside programming, and FFT module is logical
Cross call Quartus II in FFT kernel function realize, ADC acquisition module be based on sampling clock acquire respectively in circuit under test to
The information of voltage of object and reference resistance both ends is surveyed, FFT is based on reference clock and transformation points and voltage time-domain signal is converted to frequency
Domain signal.
Further, the parameter calculating module is realized by FPGA inside programming.
Further, the USB serial port module cooperates USB to turn serial ports hardware module and realizes by FPGA inside programming.
The present invention also adopts the following technical scheme that；A kind of measurement method of portable frequency sweep impedance bioelectrical measurement system, step
It is as follows:
Step 1: computer sends set of frequency control command to fpga chip by USB serial port module, lead to inside FPGA
It crosses programming and generates DDS frequency sweep unit, cooperation DAC hardware module constitutes swept signal source；
Step 2: swept frequency excitation signal is accessed peripheral circuit module, realize that double channel A/D is adopted by ADC acquisition module
Collection, determinand and feedback resistance R are acquired based on sampling clock respectively1, R2Or R3The information of voltage at both ends；
Step 3: being based on reference clock and transformation by calling the FFT kernel function in Quartus II to realize FFT module
Voltage time-domain signal is converted to frequency-region signal by points；
Step 4: by FPGA inside programming realize parameter calculating module, calculated according to the frequency domain data of two-way FFT to
Object complex impedance is surveyed, and the frequency sweep point based on computer control screens calculated result, and the selection result is finally inputted FIFO
Latch is latched；
It is analyzed step 5: finally controlling FPGA cooperation USB serial port module and impedance modal data being transferred to PC host computer
Processing.
The invention has the following beneficial effects: the portable frequency sweep impedance bioelectrical measurement systems of the present invention to be based on self-balancing bridge circuit
Circuit can effectively reduce influence of the shunt effect to measurement result.The portable frequency sweep impedance bioelectrical measurement system of the present invention has
Sweep measurement function compensates for general impedance measuring equipment single-frequency measurement on the basis of meeting measurement accuracy and frequency range
Deficiency；And it is calculated based on hardware realization Fourier transformation and parameter, substantially increases measurement efficiency and the degree of automation.This
It is relatively independent to invent portable frequency sweep impedance bioelectrical measurement system modules, it can be by improving local module performance improvement globality
Energy.
Detailed description of the invention:
Fig. 1 is the whole hardware block diagram of the present invention.
Fig. 2 is peripheral circuit schematic diagram of the present invention.
Fig. 3 is swept signal source functional block diagram of the present invention.
Specific embodiment:
The present invention will be further described below with reference to the drawings.
The portable frequency sweep impedance bioelectrical measurement system of the present invention includes being used as PC host computer 1, slave computer and system clock 2,
Slave computer is swashed using fpga chip as main body including peripheral circuit module 10, the generation frequency sweep with determinand composition circuit under test
It encourages the swept signal generator of signal, determinand in circuit under test and reference resistance both end voltage be acquired and the ADC of FFT
Acquisition and FFT module 7, parameter calculating module and reality that two-way FFT data progress impedance computation and specific frequency point are screened
The USB serial port module 3 of the communication of existing slave computer and host computer.
Peripheral circuit module 10 is the self-balancing bridge circuit circuit built using operational amplifier chip THS4221, can be had
Effect solves the influence that acquisition module shunts, wherein selecting resistance value size is respectively 100 Ω, the pure resistance of 1K Ω, 10K Ω are as ginseng
Resistance is examined, different ranges are switched.
Swept signal generator cooperates DAC hardware module to realize by the software module that FPGA inside programming is constituted.Software
The waveform of the sine wave of phase accumulator and frequency accumulator and storage a cycle that module is 32 by data bit width is deposited
Reservoir is constituted, and hardware module is made of D/A conversion circuit and filter amplification circuit
ADC acquisition module 9 and FFT module 7, ADC acquisition module cooperate ADC hardware module real by FPGA inside programming
Existing, FFT is by calling the FFT kernel function in Quartus II to realize.ADC acquisition module is acquired to be measured respectively based on sampling clock
The information of voltage of determinand and reference resistance both ends in circuit, FFT are based on reference clock and transformation points for voltage time-domain signal
Be converted to frequency-region signal.
Parameter calculating module is realized by FPGA inside programming.It is calculated according to the frequency domain data of two-way FFT transform to be measured
Object complex impedance, and the frequency sweep point based on computer control screens calculated result, finally by the selection result input FIFO lock
Storage is latched.
USB serial port module 3 cooperates USB to turn serial ports hardware module and realizes by FPGA inside programming.The module is realized upper
The communication of machine and slave computer sends PC control order and slave computer measurement result.Host computer interface is extended simultaneously, is
Subsequent impedance spectrum Data Analysis Services provide convenience.
Fig. 1 is to instantiate whole hardware block diagram of the invention.Firstly, computer passes through USB serial port module 3 to FPGA core
Piece sends set of frequency control command, generates DDS frequency sweep unit 4 by programming inside FPGA, cooperates 8 structure of DAC hardware module
At swept signal source；Swept frequency excitation signal is accessed into peripheral circuit module 10, realizes that double channel A/D is adopted by ADC acquisition module 9
Collection, determinand 11 and feedback resistance R are acquired based on sampling clock respectively112, R213 or R3The information of voltage at 14 both ends；Pass through
It calls the FFT kernel function in Quartus II to realize FFT module (7), is believed voltage time domain based on reference clock and transformation points
Number be converted to frequency-region signal；Parameter calculating module 6 is realized by FPGA inside programming, is counted according to the frequency domain data of two-way FFT
Determinand complex impedance is calculated, and the frequency sweep point based on computer control screens calculated result, finally inputs the selection result
FIFO latch 5 is latched；Final control FPGA cooperation USB serial port module 3 by impedance modal data be transferred to PC host computer 1 into
Row analysis processing.
Fig. 2 is to instantiate 10 schematic diagram of peripheral circuit module of the invention.Using chip THS4221 as operational amplifier
15, wherein selecting resistance value size is respectively 100 Ω, the pure resistance R of 1K Ω, 10K Ω112, R213, R314 are used as feedback resistance, cut
Change different ranges.Determinand Zdut11 and operational amplifier 15 connect, v be 8 structure of DDS swept-frequency signal unit 4 and DAC hardware module
At swept signal source, v1And v2For ADC acquisition module 9.Build self-balancing bridge circuit circuit as shown in the figure, determinand Zdut11
It is empty disconnected with being generated at 15 tie point of operational amplifier, it can effectively solve the influence of acquisition module shunting.Determinand Zdut(11) multiple resistance
It is anti-to be acquired by following formula:
Wherein, αdutAnd αRRespectively V1And V2Phase, φ ZdutPhase.
Fig. 3 is to instantiate 4 functional block diagram of DDS frequency sweep unit of the invention.The phase that the unit is 32 by data bit width
Accumulator 19, frequency accumulator 16, the ROM table 22 for storing a cycle sine wave and system clock 2 are constituted.Frequency accumulator
16 are made of accumulator 17 and register 18, and phase accumulator 19 accumulator 20 and register 21 by being made of.Phase accumulator
19 and ROM table 22 can produce single frequency sinusoidal signal, and addressing is overflowed after the completion of cycle sinusoidal signal addressing.Then frequency accumulator 16
The frequency being arranged by PC host computer 1 carries out control to frequency control word K and adds up, and generates new frequency control word, ultimately generates
Swept-frequency signal.
Peripheral circuit module 10 in the present invention is based on self-balancing bridge circuit method, can effectively reduce shunt effect to measurement
As a result influence.DDS swept-frequency signal unit 4 and DAC hardware module 8 constitute swept signal source, so that the present invention is surveyed with frequency sweep
Function is measured, on the basis of meeting measurement accuracy and frequency range, compensates for the deficiency of general impedance measuring equipment single-frequency measurement.
And the present invention is based on hardware realization FFT modules 7 and parameter calculating module 6, substantially increase measurement efficiency and the degree of automation.
The portable frequency sweep impedance bioelectrical measurement system modules of the present invention are relatively independent, can be whole by improving local module performance improvement
Performance.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
It for member, can also make several improvements without departing from the principle of the present invention, these improvement also should be regarded as of the invention
Protection scope.
Claims (7)
1. a kind of portable frequency sweep impedance bioelectrical measurement system, it is characterised in that: include:
PC host computer (1)；
Slave computer；
System clock (2)；
Peripheral circuit module (10) forms circuit under test with determinand (11)；
Swept signal generator is configured to DDS swept-frequency signal unit (4) cooperation DAC hardware module (8) of FPGA inside programming
Swept frequency excitation signal is generated, is then applied in circuit under test；
ADC acquisition and FFT module are configured to ADC acquisition module (9) and acquire determinand (11) and feedback in circuit under test respectively
Resistance R1(12), R2(13) or R3(14) then the information of voltage at both ends carries out two-way information of voltage collected respectively
FFT；
It is configured to calculate determinand complex impedance based on the frequency domain data of two-way FFT transform parameter calculating module (16), and base
Calculated result is screened in the frequency sweep point of computer control, finally locks the selection result input FIFO latch (5)
It deposits.
USB serial port module (3), be configured to realize slave computer and PC host computer (1) communication, transmission PC control order and
Slave computer measurement result.
2. portable frequency sweep impedance bioelectrical measurement system as described in claim 1, it is characterised in that: the peripheral circuit module
(10) the self-balancing bridge circuit circuit to be built using operational amplifier chip THS4221.
3. portable frequency sweep impedance bioelectrical measurement system as claimed in claim 2, it is characterised in that: the swept-frequency signal occurs
Device cooperates DAC hardware module to realize by the software module that FPGA inside programming is constituted, and software module is 32 by data bit width
Phase accumulator and frequency accumulator and store a cycle sine wave wave memorizer constitute, hardware module is by D/
A conversion circuit and filter amplification circuit are constituted.
4. portable frequency sweep impedance bioelectrical measurement system as claimed in claim 3, it is characterised in that: the ADC acquisition module is logical
It crosses FPGA inside programming cooperation ADC hardware module and realizes that FFT module is realized by the FFT kernel function in calling Quartus II,
ADC acquisition module acquires the information of voltage of determinand and reference resistance both ends in circuit under test, FFT base based on sampling clock respectively
Voltage time-domain signal is converted into frequency-region signal in reference clock and transformation points.
5. portable frequency sweep impedance bioelectrical measurement system as claimed in claim 4, it is characterised in that: the parameter calculating module,
It is realized by FPGA inside programming.
6. portable frequency sweep impedance bioelectrical measurement system as claimed in claim 5, it is characterised in that: the USB serial port module is led to
It crosses FPGA inside programming cooperation USB and turns the realization of serial ports hardware module.
7. a kind of measurement method of portable frequency sweep impedance bioelectrical measurement system, it is characterised in that: steps are as follows:
Step 1: computer sends set of frequency control command to fpga chip by USB serial port module (3), lead to inside FPGA
It crosses programming and generates DDS frequency sweep unit (4), cooperation DAC hardware module (8) constitutes swept signal source；
Step 2: swept frequency excitation signal is accessed peripheral circuit module (10), double channel A/D is realized by ADC acquisition module (9)
Acquisition, determinand (11) and feedback resistance R are acquired based on sampling clock respectively1(12), R2(13) or R3(14) voltage at both ends
Information；
Step 3: being based on reference clock and change point by calling the FFT kernel function in Quartus II to realize FFT module (7)
Voltage time-domain signal is converted to frequency-region signal by number；
Step 4: by FPGA inside programming realize parameter calculating module (6), calculated according to the frequency domain data of two-way FFT to
Object complex impedance is surveyed, and the frequency sweep point based on computer control screens calculated result, and the selection result is finally inputted FIFO
Latch (5) is latched；
Divided step 5: finally controlling FPGA cooperation USB serial port module (3) and impedance modal data being transferred to PC host computer (1)
Analysis processing.
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Cited By (7)
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| CN111338427A (en) * | 2020-02-27 | 2020-06-26 | 深圳航天科技创新研究院 | Method for realizing SystemC semi-physical simulation time synchronization |
| CN113080923A (en) * | 2021-03-23 | 2021-07-09 | 桂林电子科技大学 | Equivalent bioelectrical impedance measuring method based on bridge method |
| CN114113227A (en) * | 2021-11-22 | 2022-03-01 | 江苏济纶医工智能科技有限公司 | Measuring system and measuring method |
| CN114137305A (en) * | 2021-12-27 | 2022-03-04 | 苏州格里德医学传感技术有限公司 | Frequency response test instrument and complex impedance test instrument |
| CN114245284A (en) * | 2021-12-10 | 2022-03-25 | 深圳市精泰达科技有限公司 | Microphone performance detection method and system |
| CN114415553A (en) * | 2021-12-07 | 2022-04-29 | 西安交通大学 | Scanning driving system and method of photoelectric device |
| CN116539960A (en) * | 2023-07-06 | 2023-08-04 | 西安智多晶微电子有限公司 | Power supply integrity PDN target impedance acquisition method |
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| CN114137305A (en) * | 2021-12-27 | 2022-03-04 | 苏州格里德医学传感技术有限公司 | Frequency response test instrument and complex impedance test instrument |
| CN116539960A (en) * | 2023-07-06 | 2023-08-04 | 西安智多晶微电子有限公司 | Power supply integrity PDN target impedance acquisition method |
| CN116539960B (en) * | 2023-07-06 | 2023-10-13 | 西安智多晶微电子有限公司 | Power supply integrity PDN target impedance acquisition method |
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