CN110122498A - A kind of control bacterium composite bactericide and preparation method thereof under Acid-Base System - Google Patents
A kind of control bacterium composite bactericide and preparation method thereof under Acid-Base System Download PDFInfo
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- CN110122498A CN110122498A CN201910473661.9A CN201910473661A CN110122498A CN 110122498 A CN110122498 A CN 110122498A CN 201910473661 A CN201910473661 A CN 201910473661A CN 110122498 A CN110122498 A CN 110122498A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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Abstract
The invention discloses the control bacterium composite bactericide under a kind of Acid-Base System, in the formula of fungicide, in parts by weight, comprising:
Description
Technical field
The present invention relates to fungicide fields, and in particular to control bacterium composite bactericide and its preparation side under a kind of Acid-Base System
Method.
Background technique
Fungicide is also known as biocide, Biocidal algae-killing agent, microbicide etc., and typically referring in industrial bactericide can be effective
The chemicals of ground control or kill microorganism -- bacterium, fungi and algae.By studying for a long time, facts proved that current
Fungicide can substantially be divided into oxidizing bactericide and non oxidizing bactericide two major classes.Oxidizing bactericide can make protein
Denaturation mainly reaches sterilization purpose and oxidation occurs with bacterial body intracellular metabolite enzyme.Non oxidizing bactericide is mainly
Complex compound sediment is formed with certain components of bacterium after the internal of bacterium can be penetrated into or hydrolyzed in water to kill to reach
It goes out or inhibits the purpose of bacterium.But the difficulty of processing of non oxidizing bactericide is larger, is possible to after Disinfection Effect and use
The extent of injury caused by human body is difficult to control.
Method using most common non oxidizing bactericide is that quaternary ammonium salt is added into basis material, is asked there are following
Topic: the pH value and water quality of use environment will affect the effect for being added to the fungicide of quaternary ammonium salt;In alkaline solution, sterilization
Effect is most strong, but when PH=3, the effect of fungicide is worst.Add the fungicide of quaternary ammonium salt due to suction-operated, has carried out
High concentration thimerosal kills in Experiment on Microbiology, its inhibiting effect to microorganism can not be reduced with dilution method;The sterilization of quaternary ammonium salt
Agent in use, if accidentally being swallowed by children, or is rubbed on skin, can all be threatened to the health of body.
Summary of the invention
It is an object of the invention to overcome problem above of the existing technology, the control bacterium provided under a kind of Acid-Base System is multiple
With fungicide and preparation method, hidden danger is not present to the monitoring of human body in the non-oxidative bactericide in inventive formulation;In pH value
There is effect of preferably killing livestock in the range of being 6.0~9.0,94%~99%, Neng Gouti is positively retained to the killing rate of fungi
The bactericidal effect of high fungicide.
To realize above-mentioned technical purpose and the technique effect, the invention is realized by the following technical scheme:
A kind of control bacterium composite bactericide under Acid-Base System, in the formula of fungicide, in parts by weight, comprising:
Wherein, the isopropanol is organic compound, and the isopropanol can be dissolved in water, alcohol, ether, benzene and chlorine, isopropanol
Critical-temperature be 275.2 DEG C, the isopropanol be colorless and transparent liquid, have the smell like ethyl alcohol and acetone mixture;
The lauryl sodium sulfate is the anionic surfactant that can be dissolved in water, the anionic surfactant
Fusing point be 204 DEG C -207 DEG C, biological degradability > 90% of the lauryl sodium sulfate;
The virginiamycin includes the M1 component of 70%-80% and the S1 component of 20%-30%;The M1 group is divided into
The M1 factor, the S1 group are divided into S1 molecule;
It is light yellow clear oily liquids under the vegetable oil acid room temperature, 13.4 DEG C of the fusing point of the vegetable oil acid is solvable
In organic solvents such as ethyl alcohol, gasoline.The vegetable oil acid is changed into stearic acid in hydrogenation, the general chemistry with organic carboxyl acid
The chemical property of property and unsaturated double-bond.
The non-oxidative bactericide includes one or more of following: isothiazolinone, trimethyl chlorine
Change ammonium and tetramethyl ammonium chloride.
Preferably, the formula of the fungicide, in parts by weight, comprising:
72 parts of isopropanols, 4 parts of lauryl sodium sulfate, 5 parts of sodium xylene sulfonates, 0.8 part of polyvinyl alcohol, 2 parts of vegetable oil
Acid, 0.2 part of virginiamycin, 1 part of non-oxidative bactericide and 15 parts of ethyl alcohol.
Preferably, the preparation method of the control bacterium composite bactericide under the Acid-Base System, which is characterized in that including
Following steps:
Step 1: component each in formula is weighed, by lauryl sodium sulfate or sodium xylene sulfonate and poly- second
Enol is put into reaction kettle, is stirred under normal pressure, and at 90-150 DEG C, time control is completed in 20-90min for temperature control
Chemical reaction between each material;
Step 2: virginiamycin is added in mixed material into step 1 and is uniformly mixed material;
Step 3: the mixed material for obtaining step 2 under the conditions of 70-150 DEG C of temperature is stirred 30-150min,
It is down to room temperature after mixing evenly;
It is adequately mixed Step 4: the material in step 3 is put into ethanol solution, mixing is completed to be placed on
At cool place is dry;
Step 5: the vegetable oil acid is put into ethanol solution, adequately fusion and high-speed stirred are carried out, by step
Material mixed solution obtained in two is added in the ethanol solution calculated containing vegetable oil, obtains the semi-finished product of fungicide;
Step 6: non-oxidative bactericide is added in the semi-finished product of fungicide into step 5, it is sufficiently mixed;
Step 7: carrying out the semi-finished product of fungicide mixing and emulsifying 1-4 hours under conditions of 20-80 DEG C, it is down to room temperature,
Finished product can be obtained.
Step 8: carrying out all-round property testing to the fungicide prepared in step 7.
The beneficial effects of the present invention are:
In control bacterium compound sterilizing agent prescription under Acid-Base System of the invention, it is added in original bacteriocide formula non-
Oxidizing biocides, and physical mixed has been carried out to each component of fungicide, the bactericidal effect of fungicide is improved, it can
It is enough more efficiently to be sterilized.
Contain polyvinyl alcohol in the present invention, polyvinyl alcohol is had now been found that uniquely with water-soluble and nontoxic height
Polymers 46 days degradable 75%, belongs to a kind of Biodegradable polymer material, can be mass-produced under the action of enzyme, valence
Lattice are cheap.
Surfactant of the lauryl sodium sulfate in the present invention as fungicide, there is good decontamination and dispersibility
Can, strengthen the quality of product.
Vegetable oil acid in this microbiocidal composition, good flowing properties avoid other component mixing point in process
The non-uniform phenomenon of cloth.
The preparation of the fungicide of invention is using nontoxic plant source raw material, and product is nontoxic, not to human body
With any toxic action, use is also safer, environmentally friendly;The compatible use energy that the fungicide passes through contained drug component
It is enough that there is preferable killing and inhibiting effect, and effective sterilization of fungicide to most harmful bacterias, virus and part insect pest
Time is able to maintain that at 15 days or more.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And can be implemented in accordance with the contents of the specification, it is shown in detail below with presently preferred embodiments of the present invention.
Specific embodiment
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
Comparative example
In the comparative example, non-oxidative bactericide is not added, the control bacterium composite bactericide under a kind of Acid-Base System of acquisition,
Formula is as shown in table 1.
Component | Content (parts by weight) |
Isopropanol | 60-90 |
Lauryl sodium sulfate | 3-10 |
Sodium xylene sulfonate | 2-12.5 |
Polyvinyl alcohol | 0.2-3.5 |
Vegetable oil acid | 2-8 |
Virginiamycin | 0.1-1 |
Ethyl alcohol | 5-30 |
By the different proportion of each component, the control bacterium composite bactericide under a kind of Acid-Base System is prepared, by performance test,
Work as formula are as follows: 72 parts of isopropanols, 4 parts of lauryl sodium sulfate, 5 parts of sodium xylene sulfonates, 0.8 part of polyvinyl alcohol, 2 parts of vegetable oil
Acid, when 0.2 part of virginiamycin and 15 parts of ethyl alcohol, the comprehensive performance of fungicide is best.
Therefore, subsequent embodiment, for when ethyl alcohol is 15 parts.
Embodiment 1
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 1, formula is as shown in table 1.
The formula table of 1 embodiment 1 of table
Embodiment 2
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 2, formula is as shown in table 2.
The formula table of 2 embodiment 2 of table
Component | Content (parts by weight) |
Isopropanol | 72 |
Lauryl sodium sulfate | 4 |
Sodium xylene sulfonate | 5 |
Polyvinyl alcohol | 0.8 |
Vegetable oil acid | 2 |
Virginiamycin | 0.2 |
Ethyl alcohol | 15 |
Isothiazolinone | 1.4 |
Embodiment 3
Embodiment 3 discloses the control bacterium composite bactericide under a kind of Acid-Base System, and formula is as shown in table 3.
The formula table of 3 embodiment 3 of table
Embodiment 4
Embodiment 4 discloses the control bacterium composite bactericide under a kind of Acid-Base System, and formula is as shown in table 4.
The formula table of 4 embodiment 4 of table
Component | Content (parts by weight) |
Isopropanol | 72 |
Lauryl sodium sulfate | 4 |
Sodium xylene sulfonate | 5 |
Polyvinyl alcohol | 0.8 |
Vegetable oil acid | 2 |
Virginiamycin | 0.2 |
Ethyl alcohol | 15 |
Isothiazolinone | 2 |
Embodiment 5
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 5, formula is as shown in table 5.
The formula table of 5 embodiment 5 of table
Embodiment 6
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 6, formula is as shown in table 6.
The formula table of 6 embodiment 6 of table
Embodiment 7
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 7, formula is as shown in table 7.
The formula table of 7 embodiment 7 of table
Embodiment 8
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 8, formula is as shown in table 8.
The formula table of 8 embodiment 8 of table
Embodiment 9
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 9, formula is as shown in table 9.
Formula table in 9 embodiment 9 of table
Embodiment 10
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 10, formula is as shown in table 10.
Formula table in 10 embodiment 10 of table
Component | Content (parts by weight) |
Isopropanol | 72 |
Lauryl sodium sulfate | 4 |
Sodium xylene sulfonate | 5 |
Polyvinyl alcohol | 0.8 |
Vegetable oil acid | 2 |
Virginiamycin | 0.2 |
Ethyl alcohol | 15 |
Tetramethyl ammonium chloride | 1.4 |
Embodiment 11
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 11, formula is as shown in table 11.
Formula table in 11 embodiment 11 of table
Embodiment 12
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 12, formula is as shown in Table 12.
Formula table in 12 embodiment 12 of table
Component | Content (parts by weight) |
Isopropanol | 72 |
Lauryl sodium sulfate | 4 |
Sodium xylene sulfonate | 5 |
Polyvinyl alcohol | 0.8 |
Vegetable oil acid | 2 |
Virginiamycin | 0.2 |
Ethyl alcohol | 15 |
Tetramethyl ammonium chloride | 1.9 |
Embodiment 13
The control bacterium composite bactericide under a kind of Acid-Base System is disclosed in embodiment 13, formula is as shown in table 13.
Formula table in 13 embodiment 13 of table
Component | Content (parts by weight) |
Isopropanol | 72 |
Lauryl sodium sulfate | 4 |
Sodium xylene sulfonate | 5 |
Polyvinyl alcohol | 0.8 |
Vegetable oil acid | 2 |
Virginiamycin | 0.2 |
Ethyl alcohol | 15 |
Tetramethyl ammonium chloride | 2.5 |
In above-described embodiment 1-13, above-mentioned isopropanol is organic compound, and isopropanol can be dissolved in ethyl alcohol, alcohol, ether, benzene
And chlorine, the critical-temperature of isopropanol are 275.2 DEG C, isopropanol is colorless and transparent liquid, is had like ethyl alcohol and acetone mixture
Smell;Density of the above-mentioned non-oxidative bactericide at 20 DEG C is 1.26g/cm-1.32g/cm;Above-mentioned lauryl sodium sulfate is
It can be dissolved in the anionic surfactant of water, the fusing point of anionic surfactant is 204 DEG C -207 DEG C, dodecyl sulphate
Biological degradability > 90% of sodium;Above-mentioned virginiamycin includes the M1 component of 70%-80% and the S1 component of 20%-30%;
Above-mentioned M1 group is divided into the M1 factor, and above-mentioned S1 group is divided into S1 molecule.It is light yellow clear oily liquids under above-mentioned vegetable oil acid room temperature,
13.4 DEG C of the fusing point of above-mentioned vegetable oil acid, dissolves in the organic solvents such as ethyl alcohol, gasoline.Above-mentioned vegetable oil acid is changed into hydrogenation
Stearic acid, the chemical property of general chemical property and unsaturated double-bond with organic carboxyl acid;Above-mentioned non-oxidative bactericide packet
It includes one or more of following: isothiazolinone, dodecyl trimethyl ammonium chloride and tetramethyl ammonium chloride.
Contain polyvinyl alcohol in the present invention, polyvinyl alcohol is that have now been found that unique has water-soluble and nontoxic height poly-
Object 46 days degradable 75%, belongs to a kind of Biodegradable polymer material, can be mass-produced under the action of enzyme, price
It is cheap.
Surfactant of the lauryl sodium sulfate in the present invention as fungicide, there is good decontamination and dispersibility
Can, strengthen the quality of product.
Vegetable oil acid in this microbiocidal composition, good flowing properties avoid other component mixing point in process
The non-uniform phenomenon of cloth.
The preparation of the fungicide of invention is using nontoxic plant source raw material, and product is nontoxic, not to human body
With any toxic action, use is also safer, environmentally friendly;The compatible use energy that the fungicide passes through contained drug component
It is enough that there is preferable killing and inhibiting effect, and effective sterilization of fungicide to most harmful bacterias, virus and part insect pest
Time is able to maintain that at 15 days or more.
Preparation method
For embodiment 1-4 using isothiazolinone as non-oxidative bactericide, preparation method is as follows:
Step 1: component each in formula is weighed, by lauryl sodium sulfate or sodium xylene sulfonate and poly- second
Enol is put into reaction kettle, is stirred under normal pressure, and at 90-150 DEG C, time control is completed in 20-90min for temperature control
Chemical reaction between each material;
Step 2: virginiamycin is added in mixed material into step 1 and is uniformly mixed material;
Step 3: the mixed material for obtaining step 2 under the conditions of 70-150 DEG C of temperature is stirred 30-150min,
It is down to room temperature after mixing evenly;
It is adequately mixed Step 4: the material in step 3 is put into ethanol solution, mixing is completed to be placed on
At cool place is dry;
Step 5: the vegetable oil acid is put into ethanol solution, adequately fusion and high-speed stirred are carried out, by step
Material mixed solution obtained in two is added in the ethanol solution calculated containing vegetable oil, obtains the semi-finished product of fungicide;
Step 6: isothiazolinone is added in the semi-finished product of fungicide into step 5, it is sufficiently mixed;
Step 7: carrying out the semi-finished product of fungicide mixing and emulsifying 1-4 hours under conditions of 20-80 DEG C, it is down to room temperature,
Finished product can be obtained.
Step 8: carrying out all-round property testing to the fungicide prepared in step 7.
For embodiment 5-9 using dodecyl trimethyl ammonium chloride as non-oxidative bactericide, preparation method is as follows:
Step 1: component each in formula is weighed, by lauryl sodium sulfate or sodium xylene sulfonate and poly- second
Enol is put into reaction kettle, is stirred under normal pressure, and at 90-150 DEG C, time control is completed in 20-90min for temperature control
Chemical reaction between each material;
Step 2: virginiamycin is added in mixed material into step 1 and is uniformly mixed material;
Step 3: the mixed material for obtaining step 2 under the conditions of 70-150 DEG C of temperature is stirred 30-150min,
It is down to room temperature after mixing evenly;
It is adequately mixed Step 4: the material in step 3 is put into ethanol solution, mixing is completed to be placed on
At cool place is dry;
Step 5: the vegetable oil acid is put into ethanol solution, adequately fusion and high-speed stirred are carried out, by step
Material mixed solution obtained in two is added in the ethanol solution calculated containing vegetable oil, obtains the semi-finished product of fungicide;
Step 6: dodecyl trimethyl ammonium chloride is added in the semi-finished product of fungicide into step 5, it is sufficiently mixed;
Step 7: carrying out the semi-finished product of fungicide mixing and emulsifying 1-4 hours under conditions of 20-80 DEG C, it is down to room temperature,
Finished product can be obtained.
Step 8: carrying out all-round property testing to the fungicide prepared in step 7.
For embodiment 10-13 using tetramethyl ammonium chloride as non-oxidative bactericide, preparation method is as follows:
Step 1: component each in formula is weighed, by lauryl sodium sulfate or sodium xylene sulfonate and poly- second
Enol is put into reaction kettle, is stirred under normal pressure, and at 90-150 DEG C, time control is completed in 20-90min for temperature control
Chemical reaction between each material;
Step 2: virginiamycin is added in mixed material into step 1 and is uniformly mixed material;
Step 3: the mixed material for obtaining step 2 under the conditions of 70-150 DEG C of temperature is stirred 30-150min,
It is down to room temperature after mixing evenly;
It is adequately mixed Step 4: the material in step 3 is put into ethanol solution, mixing is completed to be placed on
At cool place is dry;
Step 5: the vegetable oil acid is put into ethanol solution, adequately fusion and high-speed stirred are carried out, by step
Material mixed solution obtained in two is added in the ethanol solution calculated containing vegetable oil, obtains the semi-finished product of fungicide;
Step 6: tetramethyl ammonium chloride is added in the semi-finished product of fungicide into step 5, it is sufficiently mixed;
Step 7: carrying out the semi-finished product of fungicide mixing and emulsifying 1-4 hours under conditions of 20-80 DEG C, it is down to room temperature,
Finished product can be obtained.
Step 8: carrying out all-round property testing to the fungicide prepared in step 7.
Performance evaluation
The sample of the fungicide prepared in above-described embodiment 1-4,5-9,10-13 and in comparative example is analyzed.
(1) toxicity test result
Fungicide and standard hard water of the invention are diluted by 1:50 when test, whether activity after observation rat oral gavage administration
There is irritated phenomenon, and restore the normal time, the death rate of rat is recorded during test, to judge composite bactericidal of the invention
Whether agent is toxic.
(2) skin irritation is tested
During test, whether the tested side of observation animal subject and control skin have abnormal response, check skin irritation index,
It checks histopathologic examination's integral, judges whether compound disinfectant of the invention has obvious irritation to animal skin.
(3) inhibit plant pathogeny line insect test
It carries out inhibiting plant pathogeny line insect test using dip method, to measure the inhibition to nematode second instar larvae of fungicide
Activity.
Sample in embodiment 1-4 is tested for the property, result is as shown in table 14.
Test result table in 14 embodiment 1-4 of table
By, it is found that being not added with any non-oxidative bactericide in comparative example, rats death rate is 1.6, is added different in table 14
After thiazolinone, the death rate of rat is begun to ramp up, and when the content of isothiazolinone is 2 parts, the death rate of rat gets to maximum
Value.Any non-oxidative bactericide is not added in comparative example, rat skin stimulus index is 1.6, after isothiazolinone is added, greatly
The skin irritation index of mouse is begun to decline, and when the content of isothiazolinone is 2 parts, the skin irritation index of rat gets to maximum
Value.Any non-oxidative bactericide is not added in comparative example, the pathogenic nematode survival rate of fungicide is 4.51, and isothiazoline is added
After ketone, the pathogenic nematode survival rate of fungicide is begun to decline, and proportional with the additive amount of isothiazolinone.
It with embodiment 1 is most preferred embodiment in embodiment 1-4 shown in sum up.
To being tested for the property in embodiment 5-8, result is as shown in table 15.
The performance test results table in 15 embodiment 5-8 of table
By, it is found that being not added with any non-oxidative bactericide in comparative example, rats death rate is 1.6, is added ten in table 15
After dialkyl group trimethyl ammonium chloride, the death rate of rat is begun to ramp up, when the content of dodecyl trimethyl ammonium chloride is 2 parts
The death rate of rat is highest.Any non-oxidative bactericide is not added in comparative example, rat skin stimulus index is 1.6, is added
After entering dodecyl trimethyl ammonium chloride, the skin irritation index of rat is begun to ramp up, when the content of isothiazolinone is 2 parts
The skin irritation index of rat gets to maximum value.Any non-oxidative bactericide, the cause of disease line of fungicide are not added in comparative example
Worm survival rate is 4.51, and after isothiazolinone is added, the pathogenic nematode survival rate of fungicide is begun to decline, and and dodecyl
The additive amount of trimethyl ammonium chloride is proportional.
It with embodiment 5 is most preferred embodiment in embodiment 5-8 shown in sum up.
Embodiment 9-13 is tested for the property, result is as shown in table 16.
The performance test results table in 16 embodiment 9-13 of table
By, it is found that being not added with any non-oxidative bactericide in comparative example, rats death rate is 1.6, is added four in table 16
After ammonio methacrylate, the death rate of rat is begun to ramp up, and when the content of tetramethyl ammonium chloride is 2 parts, the death rate of rat is most
It is high.Any non-oxidative bactericide is not added in comparative example, rat skin stimulus index is 1.6, after tetramethyl ammonium chloride is added,
The skin irritation index of rat is begun to ramp up, and when the content of tetramethyl ammonium chloride is 2 parts, the skin irritation index of rat is got to
Maximum value.Any non-oxidative bactericide is not added in comparative example, the pathogenic nematode survival rate of fungicide is 4.51, and tetramethyl is added
After ammonium chloride, the pathogenic nematode survival rate of fungicide is begun to decline, and proportional with the additive amount of tetramethyl ammonium chloride.
In conclusion embodiment 9 is most preferred embodiment.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (3)
1. the control bacterium composite bactericide under a kind of Acid-Base System, which is characterized in that in the formula of fungicide, according to parts by weight
Meter, comprising:
Wherein, the isopropanol is organic compound, and the isopropanol can be dissolved in water, alcohol, ether, benzene and chlorine, and isopropanol faces
Boundary's temperature is 275.2 DEG C, and the isopropanol is colorless and transparent liquid, there is the smell like ethyl alcohol and acetone mixture;
The lauryl sodium sulfate is the anionic surfactant that can be dissolved in water, and the anionic surfactant melts
Point is 204 DEG C -207 DEG C, biological degradability > 90% of the lauryl sodium sulfate;
The virginiamycin includes the M1 component of 70%-80% and the S1 component of 20%-30%;The M1 group be divided into M1 because
Son, the S1 group are divided into S1 molecule;
It is light yellow clear oily liquids under the vegetable oil acid room temperature, 13.4 DEG C of the fusing point of the vegetable oil acid dissolves in second
The organic solvents such as alcohol, gasoline.The vegetable oil acid is changed into stearic acid in hydrogenation, the general chemical property with organic carboxyl acid
And the chemical property of unsaturated double-bond.
The non-oxidative bactericide includes one or more of following: isothiazolinone, dodecyl trimethyl ammonium chloride
And tetramethyl ammonium chloride.
2. the control bacterium composite bactericide under a kind of Acid-Base System according to claim 1, which is characterized in that the fungicide
Formula, in parts by weight, comprising:
72 parts of isopropanols, 4 parts of lauryl sodium sulfate, 5 parts of sodium xylene sulfonates, 0.8 part of polyvinyl alcohol, 2 parts of vegetable oil acids,
0.2 part of virginiamycin, 1 part of non-oxidative bactericide and 15 parts of ethyl alcohol.
3. a kind of preparation method of the control bacterium composite bactericide under Acid-Base System of any of claims 1 or 2, which is characterized in that
The following steps are included:
Step 1: component each in formula is weighed, by lauryl sodium sulfate or sodium xylene sulfonate and polyvinyl alcohol
It is put into reaction kettle, is stirred under normal pressure, at 90-150 DEG C, time control is completed each in 20-90min for temperature control
Chemical reaction between material;
Step 2: virginiamycin is added in mixed material into step 1 and is uniformly mixed material;
Step 3: the mixed material for obtaining step 2 under the conditions of 70-150 DEG C of temperature is stirred 30-150min, stirring
Room temperature is down to after uniformly;
It is adequately mixed Step 4: the material in step 3 is put into ethanol solution, mixing is completed to be placed on cool place
At dry;
Step 5: the vegetable oil acid is put into ethanol solution, adequately fusion and high-speed stirred are carried out, it will be in step 2
Obtained material mixed solution is added in the ethanol solution calculated containing vegetable oil, obtains the semi-finished product of fungicide;
Step 6: non-oxidative bactericide is added in the semi-finished product of fungicide into step 5, it is sufficiently mixed;
Step 7: carrying out the semi-finished product of fungicide mixing and emulsifying 1-4 hours under conditions of 20-80 DEG C, it is down to room temperature
Obtain finished product.
Step 8: carrying out all-round property testing to the fungicide prepared in step 7.
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